Xuejia Han, Wensi Ding, Guiwu Qu, Youjie Li, Pingyu Wang, Jiahui Yu, Mingyue Liu, Xiulan Chen, Shuyang Xie, Jiankai Feng, Sen Xu
Acute Lung Injury (ALI) manifests as an acute exacerbation of pulmonary inflammation with high mortality. The potential application of Danshensu methyl ester (DME, synthesized in our lab) in ameliorating ALI has not been elucidated. Our results demonstrated that DME led to a remarkable reduction in lung injury. DME promoted a marked increase in antioxidant enzymes, like superoxide dismutase (SOD), and glutathione (GSH), accompanied by a substantial decrease in reactive oxygen species (ROS), myeloperoxidase (MPO), and malondialdehyde (MDA)...
January 17, 2024: Respiratory Physiology & Neurobiology