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BMC Complementary and Alternative Medicine

Jingwei Li, Xiaofei Liu, Hongzhi Chen, Ziyuan Sun, Hanhan Chen, Lei Wang, Xiaohui Sun, Xiangqi Li
BACKGROUND: Development of safe and effective chemopreventive agents is a winning strategy in reducing the morbidity and mortality of breast cancer. The current study was to investigate the mechanism-based chemopreventive potential of a Chinese herb formula Yanghe Huayan (YHHY) Decoction on the classical 7,12-dimethylbenz(a)anthracene (DMBA) induced rat mammary carcinogenesis model. METHODS: Female Sprague-Dawley rats at 42 days of age were orally administered with a human equivalent dose of YHHY Decoction at 0...
February 13, 2019: BMC Complementary and Alternative Medicine
Weerachai Pipatrattanaseree, Arunporn Itharat, Nichamon Mukkasombut, Ubonwan Saesiw
BACKGROUND: The root of Baliospermum montanum has been used as an ingredient of traditional Thai medicines for the treatments of several diseases including itching eczema, muscle and joint inflammation, and cancer. Few studies have been done on phytochemical components of this root. In this study, we isolated major compounds of the crude ethanolic extract of B. montanum root and developed and validated a high performance liquid chromatographic (HPLC) method for the determination of its major components...
February 12, 2019: BMC Complementary and Alternative Medicine
Tamires Rocha Falcão, Cássio Alexandre Oliveira Rodrigues, Aurigena Antunes de Araújo, Caroline Addison Carvalho Xavier de Medeiros, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Maria Luiza Diniz de Sousa Lopes, Gerlane Coelho Bernardo Guerra
BACKGROUND: Libidibia ferrea (L. ferrea) has been used in folk medicine to treat several conditions and to prevent cancer. This study performed a chromatographic analysis of the crude aqueous extract of Libidibia ferrea (Mart. ex. Tul.) L.P. Queiroz (LfAE) leaves and evaluated its in vivo antioxidant and anti-inflammatory potential. METHODS: Polyphenols present in LfAE were characterized by high performance liquid chromatography (HPLC). Anti-inflammatory activity was studied in an experimental model of zymosan-induced intra-articular inflammation, conducted in Wistar rats treated with LfAE at the doses of 100, 200 and 300 mg/kg by gavage...
February 12, 2019: BMC Complementary and Alternative Medicine
Xiaoyan Sun, Xiushi Yang, Peng Xue, Zhiguo Zhang, Guixing Ren
BACKGROUND: Quinoa is a food crop native to the Andes. The process of dehulling quinoa can produce approximately 8-12% husk, which is often discarded because it contains bitter saponin. Saponin derived from quinoa has been reported to exhibit anti-inflammatory and antifungal activity. However, the antibacterial effects of quinoa saponin against halitosis-related bacteria are still unclear. METHODS: In this study, quinoa saponin (QS) and alkali-transformed saponin (ATS) were separated by AB-2 resin to obtain QS-30, QS-80, ATS-30 and ATS-80...
February 12, 2019: BMC Complementary and Alternative Medicine
Nor Azrina Norahmad, Mohd Ridzuan Mohd Abd Razak, Norazlan Mohmad Misnan, Nur Hana Md Jelas, Umi Rubiah Sastu, Amirrudin Muhammad, Tiffiny Chau Dee Ho, Bazilah Jusoh, Nor Azlina Zolkifli, Ravindran Thayan, Adiratna Mat Ripen, Murizal Zainol, Ami Fazlin Syed Mohamed
BACKGROUND: Carica papaya leaves have been used for traditional treatment of dengue fever and have been reported to exhibit an immunomodulatory activity by affecting the level of cytokine production in vitro and in vivo. Due to the lack of adequate in vivo evidence in dengue disease model, the present study was initiated to screen and identify the cytokines affected by freeze-dried C. papaya leaf juice (FCPLJ) treatment in AG129 mice infected with DEN-2 dengue virus. METHODS: The AG129 mice were fed orally with FCPLJ for 3 consecutive days after 24 h of dengue virus inoculation...
February 11, 2019: BMC Complementary and Alternative Medicine
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong
BACKGROUND: Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea is still insufficient. Thus, we evaluated whether extracts from the leaves (STL) and branches (STB) of S. thea exert anticancer activity and elucidated its potential mechanism in SW480 cells. METHODS: MTT assay was performed for measuring cell viability...
February 8, 2019: BMC Complementary and Alternative Medicine
Yu-Chi Wang, Jen-Huai Chiang, Hsin-Cheng Hsu, Chun-Hao Tsai
BACKGROUND: There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate. METHODS: We identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5 years), diagnosis year of osteoporosis, and index year...
February 4, 2019: BMC Complementary and Alternative Medicine
Mustafa F Alkhouli, Jun Hung, Michaela Squire, Miranda Anderson, Monica Castro, Jeganathan R Babu, Layla Al-Nakkash, Tom L Broderick, Jeffrey H Plochocki
BACKGROUND: Alzheimer's disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hypothesis that these treatments improve fracture resistance in a mouse model representative of the AD condition...
February 4, 2019: BMC Complementary and Alternative Medicine
Anna Goc, Aleksandra Niedzwiecki, Matthias Rath
BACKGROUND: Borrelia sp. is a causative pathogen of Lyme disease which has become a worldwide health concern. Non-toxic approaches especially directed toward latent persistent forms of this pathogen are desired. Lipids in the form of volatile and non-volatile oils, and fatty acids with proven anti-borreliae efficacy could become an additional support or an alternative for consideration in treatment approaches. METHODS: In this study we investigated 47 lipids (30 volatile and non-volatile oils, and 17 fatty acids) of plant and animal origin against typical motile, knob/round-shaped persisters, and biofilm-like aggregates of Borrelia burgdorferi s...
February 4, 2019: BMC Complementary and Alternative Medicine
Xufeng Yang, Dawei Lian, Pinglong Fan, Yifei Xu, Jing Wang, Fangjun Chen, Huanling Lai, Weiwen Jiang, Linjie Zhang, Ping Huang, Hongying Cao
BACKGROUND: This study aimed to elucidate the effects and mechanisms of Radix Linderae (RL) extracts on a mouse model of diabetic bladder dysfunction (DBD), especially on later decompensated phase. METHODS: Male C57BL/6J mice were intraperitoneally injected with streptozotocin (STZ) after 4 weeks of high-fat diet (HFD) feeding. DBD mouse models (later decompensated phase) were developed by 12-weeks persistent hyperglycemia and then treated with RL extracts for 4 weeks...
February 4, 2019: BMC Complementary and Alternative Medicine
Ayesha Riaz, Saleha Noureen, Iram Liqat, Muhammad Arshad, Najma Arshad
BACKGROUND: Listeria monocytogenes is an opportunistic foodborne pathogen that causes human Listeriosis and high mortality particularly in immunocompromised individuals. Pregnant women are more prone to L. monocytogenes infection resulting in abortions. In the present study, antilisterial activity of Lactobacillus brevis (LB) MF179529, a probiotic bacterial strain, was investigated in a murine model. METHODS: Initially a pilot study was conducted to determine the dose of L...
February 1, 2019: BMC Complementary and Alternative Medicine
Wuguo Li, Qing Zhang, Kaotan Chen, Zhenhua Sima, Jingli Liu, Qiang Yu, Jiawei Liu
BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells (CSCs). Constitutively activated STAT3 plays a pivotal role in holding cancer stemness of HCC CSCs, which are essential for hepatoma initiation, relapse, metastasis and drug resistance. Therefore, STAT3 has been validated as a novel anti-cancer drug target and the strategies targeting HCC CSCs may bring new hopes to HCC therapy...
February 1, 2019: BMC Complementary and Alternative Medicine
Congtao Yu, Lifen Dai, Zhaoxia Ma, Hongbin Zhao, Yong Yuan, Yunfeng Zhang, Pengfei Bao, Yanfang Su, Daiping Ma, Change Liu, Xingfei Wu, Jinxue Liu, Yanjiao Li, Bing Wang, Min Hu
BACKGROUND: Bone damage is a condition that affects the quality of life of patients. Mesenchymal stem cells (MSCs) are important for bone repair. Osteoking is a natural compound in traditional Chinese Medicine used to treat bone diseases; however, the effect of Osteoking on the differentiation of MSCs has not been reported. In this study, we aimed to investigate the effect of Osteoking on the osteogenic and adipogenic differentiation potential of rat bone marrow mesenchymal stem cells (rbMSCs)...
January 31, 2019: BMC Complementary and Alternative Medicine
Xueping Yang, Fuer Lu, Lingli Li, Jingbin Li, Jinlong Luo, Siyi Zhang, Xinqiao Liu, Guang Chen
BACKGROUND: Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically prescribed to treat diabetes mellitus in China. WMW has been shown to alleviate damage in pancreatic β cells, but the underlying mechanism remains unclear. This study aims to explore how WMW plays a protective role in pancreatic islets. METHODS: Drug testing and mechanism analyses were performed on mice treated with three concentrations of WMW (4800, 9600, and 19,200 mg/kg/bw) for four consecutive weeks...
January 31, 2019: BMC Complementary and Alternative Medicine
Munyaradzi Mukesi, Benson C Iweriebor, Larry C Obi, Uchechukwu U Nwodo, Sylvester R Moyo, Anthony I Okoh
BACKGROUND: Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia and meningitis. Ten to 37 % of pregnant women in the world are colonised with GBS while intrapartum antibiotic prophylaxis has led to significant reduction in early onset disease. The increase in drug resistant microorganisms has become a major threat. Development of vaccines is still in progress so there is need for new and safer alternatives to treatment...
January 30, 2019: BMC Complementary and Alternative Medicine
Prakash Raj Pandeya, Ramakanta Lamichhane, Kyung-Hee Lee, Se-Gun Kim, Dae-Ho Lee, Hyeong-Kyu Lee, Hyun-Ju Jung
BACKGROUND: Royal jelly (RJ) has been used traditionally for dietary, cosmetic and health purposes for a long time in different parts of the world. Scientific studies have also shown its numerous health-promoting properties including hypoglycemic and anti-hypercholesterolemic action. In this study, we investigated the anti-adipogenic activity of RJ in 3 T3-L1 cells and isolated the major responsible root component for the activity. METHODS: An active anti-adipogenic compound was isolated through bioassay-guided isolation process by successive treatment of RJ and its active fractions on 3 T3-L1 cell line...
January 29, 2019: BMC Complementary and Alternative Medicine
Wagheda Cassiem, Maryna de Kock
BACKGROUND: Colorectal malignant neoplasms is one of the leading causes of death in both men and women in the developed world and the incidence has recently increased markedly in South Africa. Studies have highlighted the beneficial effects of Amygdalin, a cyanogenic compound found in both peach and apricot kernels, in its ability to suppress the development of colon cancer. The focus of this study was to investigate the potential anti-proliferative properties of various apricot and peach kernels extractions from South Africa and China and to monitor alterations in cell cycle kinetics in colon cancer cells...
January 29, 2019: BMC Complementary and Alternative Medicine
Minkyung Kim, Dahee Son, Seoungwoo Shin, Deokhoon Park, Sangyo Byun, Eunsun Jung
BACKGROUND: Exposure of skin to urban air pollutants is closely related to skin aging and inflammatory responses such as wrinkles formation, pigmentation spot, atopic dermatitis, and acne. Thus, a great deal of interest has been focused on the development of natural resources that can provide a protective effect to skin from pollutants. METHODS: The antioxidative activity of Camellia japonica flower extract (CJFE) was evaluated by 1,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) assay, and the inhibitory effect of CJFE by urban air pollutants-induced reactive oxygen species (ROS) production was determined in cultured normal human dermal fibroblasts (NHDFs)...
January 28, 2019: BMC Complementary and Alternative Medicine
Eun Hye Han, Mi Kyung Lim, Sang Ho Lee, Md Mahbubur Rahman, Young-Hee Lim
BACKGROUND: Opuntia ficus-indica var. saboten (OFIS) is used widely in Korea to treat constipation due to its diuretic effects and its enhancement of bowel function and appetite. However, its safety has not yet been established. The aim of this study was to evaluate the repeated oral toxicity and genotoxicity of OFIS extract (OE). METHODS: White female and male Sprague Dawley rats (n = 6) were divided into 4 groups, and OE was administered to them orally (0, 500, 1000, and 2000 mg/kg/day, respectively) for one week...
January 28, 2019: BMC Complementary and Alternative Medicine
Maisa Alnaqeeb, Kenza A Mansor, Eyad M Mallah, Bayan Y Ghanim, Nasir Idkaidek, Nidal A Qinna
BACKGROUND: In-depth information of potential drug-herb interactions between warfarin and herbal compounds with suspected anticoagulant blood thinning effects is needed to raise caution of concomitant administration. The current study aimed to investigate the impact of co-administration of pomegranate peel and guava leaves extracts, including their quality markers namely; ellagic acid and quercetin, respectively, on warfarin's in vivo dynamic activity and pharmacokinetic actions, in addition to potential in vitro cytochrome P450 enzymes (CYP) inhibition...
January 24, 2019: BMC Complementary and Alternative Medicine
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