Zhong-Ping Gou, Wei Zhang, Xiu-Fang Liang, Ying Wang, Ju-Hong Mou, Mei Li, Ya Zhang, Ping Feng
BACKGROUND: This study aims to assess the tolerability and safety of DQTM tablet, which contains a complex mixture of Salvia miltiorrhiza salvianolic acids and Panax notoginseng saponins. METHODS: A double-blind, randomized, placebo-controlled phase I dose escalation study was conducted in 84 healthy volunteers. In a single ascending dose study, active ingredients were administered in various doses (90, 270, 540, 1080, 1800, 2880, 4320 or 5760 mg) to 60 subjects in cohorts 1-8...
November 27, 2019: BMC Complementary and Alternative Medicine