Ahmet Bozkurt, Gary A Brook, Sven Moellers, Franz Lassner, Bernd Sellhaus, Joachim Weis, Michael Woeltje, Julian Tank, Christina Beckmann, Paul Fuchs, Leon Olde Damink, Frank Schügner, Ingo Heschel, Norbert Pallua
The goal of this study was the development of a bioartificial nerve guide to induce axonal regeneration in the peripheral nervous system (PNS). In this in vitro study, the ability of a novel, 3-dimensional (3D), highly oriented, cross-linked porcine collagen scaffold to promote directed axonal growth has been studied. Collagen nerve guides with longitudinal guidance channels were manufactured using a series of chemical and mechanical treatments with a patented unidirectional freezing process, followed by freeze-drying (pore sizes 20-50 microm)...
December 2007: Tissue Engineering