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Journals Canadian Respiratory Journal :...

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society

https://read.qxmd.com/read/36960314/serum-bilirubin-levels-and-disease-severity-in-patients-with-pneumoconiosis
#1
JOURNAL ARTICLE
You-Fan Peng, Jun-Hua Deng, Xiao-Ying Huang, Qing-Song Zhang
AIM: To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis. METHODS: The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity. RESULTS: Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage ( p  = 0...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817552/ild-gap-combined-with-the-charlson-comorbidity-index-score-ild-gapc-as-a-prognostic-prediction-model-in-patients-with-interstitial-lung-disease
#2
JOURNAL ARTICLE
Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami, Kota Murohashi, Ryo Nagasawa, Ayako Aoki, Ami Izawa, Kenichi Seki, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
BACKGROUND: The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated. METHODS: In ILD patients, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), collagen vascular disease-related interstitial pneumonia (CVD-IP), chronic hypersensitivity pneumonitis (CHP), and unclassifiable ILD (UC-ILD), treated between April 2013 and April 2017, the relationships between baseline clinical parameters, including age, sex, CCIS, ILD diagnosis, pulmonary function test results, and disease outcomes, were retrospectively assessed, and the ability to predict prognosis was compared between the ILD-GAP and ILD-GAPC models, respectively...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817551/corrigendum-to-clinical-characteristics-of-asymptomatic-patients-with-sars-cov-2-in-zhejiang-an-imperceptible-source-of-infection
#3
Wei Dai, Xinmiao Chen, Xiaoting Xu, Zhefeng Leng, Wenwen Yu, Hui Lin, Huiying Li, Jie Lin, Zhangwei Qiu, Yuanrong Dai
[This corrects the article DOI: 10.1155/2020/2045341.].
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817550/validation-of-sequential-rox-index-score-beyond-12%C3%A2-hours-in-predicting-treatment-failure-and-mortality-in-covid-19-patients-receiving-oxygen-via-high-flow-nasal-cannula
#4
JOURNAL ARTICLE
Dimitris Basoulis, Pantelis Avramopoulos, Maria Aggelara, Georgios Karamanakos, Pantazis-Michail Voutsinas, Amalia Karapanou, Mina Psichogiou, Michalis Samarkos, Foteini Ntziora, Nikolaos V Sipsas
BACKGROUND: High-flow nasal cannula (HFNC) is an oxygen delivery method shown to reduce the risk of intubation and mortality in patients with type 1 respiratory failure. The ROX-index score can predict HFNC failure. This study aims to evaluate sequential ROX-index assessments as predictors of HFNC failure and mortality. METHODS: Prospective observational single-center study including all adult patients with positive SARS-CoV-2 PCR placed under HFNC from 1st November 2020 to 31st May 2021, and patients with hemodynamic instability or unable to tolerate HFNC were excluded...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36710924/comparative-study-of-ectopic-lymphoid-aggregates-in-sheep-and-murine-models-of-bleomycin-induced-pulmonary-fibrosis
#5
JOURNAL ARTICLE
Udari Eshani Perera, Louise Organ, Simon G Royce, Chrishan S Samuel, Habtamu B Derseh, Sasika N V Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J Snibson
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma, often manifested by dyspnea and progressive loss of lung function. The role of inflammation in the pathogenesis of IPF is not well understood. This study evaluated the histopathological and inflammatory components of bleomycin-induced pulmonary fibrosis in mouse and sheep models, in terms of their ability to translate to the human IPF. Merino sheep ( n  = 8) were bronchoscopically administered with two bleomycin infusions, two weeks apart, into a caudal lung segment, with a saline (control) administered into a caudal segment in the opposite lung...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36687390/operative-versus-nonoperative-treatment-in-patients-with-advanced-non-small-cell-lung-cancer-recommended-for-surgery
#6
JOURNAL ARTICLE
Hui Wang, Di Yang, Yan Lv, Jing Lin, Haibin Wang
BACKGROUND: There is currently limited evidence for a correlation between the recommended operation and overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC). METHODS: NSCLC patients with stages III and IV, recommended for operation, were identified in the US National Cancer Institute Surveillance, Epidemiology, and End Results database (SEER).We used propensity score matching (PSM) and multivariable Cox proportional hazards regression to ensure the robustness of our findings...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36687389/construction-and-validation-of-a-predictive-model-for-the-risk-of-ventilator-associated-pneumonia-in-elderly-icu-patients
#7
JOURNAL ARTICLE
Shuhua Li, Linping Shang, Lirong Yuan, Wei Li, Hongyun Kang, Wenting Zhao, Xiaojuan Han, Danxia Su
BACKGROUND: Ventilator-associated pneumonia (VAP) is among the most important hospital-acquired infections in an intensive-care unit setting. However, clinical practice lacks effective theoretical tools for preventing VAP in the elderly. AIM: To describe the independent factors associated with VAP in elderly intensive-care unit (ICU) patients on mechanical ventilation (MV) and to construct a risk prediction model. METHODS: A total of 1851 elderly patients with MV in ICUs from January 2015 to September 2019 were selected from 12 tertiary hospitals...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36618585/evaluation-of-follow-up-ct-scans-in-patients-with-severe-initial-pulmonary-involvement-by-covid-19
#8
JOURNAL ARTICLE
Behshad Pazooki, Ailar Ahangari, Mohammad-Mehdi Mehrabi Nejad, Nasim Batavani, Faeze Salahshour
OBJECTIVE: To investigate the predictive factors of residual pulmonary opacity on midterm follow-up CT scans in patients hospitalized with COVID-19 pneumonia. MATERIALS AND METHODS: This prospective study was conducted in a tertiary referral university hospital in Iran, from March 2020 to December 2020. Patients hospitalized due to novel coronavirus pneumonia with bilateral pulmonary involvement in the first CT scan were included and underwent an 8-week follow-up CT scan...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36582191/promising-therapeutic-functions-of-bone-marrow-mesenchymal-stem-cells-derived-exosome-in-asthma
#9
REVIEW
Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang
Asthma is a chronic inflammatory disturbance of the airways in which many cells and cellular elements are involved. Wheezing, breathlessness, chest tightness, and coughing, especially at night or in the early morning, are typical symptoms of asthma. At present, inhaled corticosteroid (ICS) and long-acting β -agonists (LABAs) are standard treatments for regular management. Oral corticosteroids (OCSs) were recommended for controlling asthma exacerbation but only for a short-term treatment because of the side effects on organs...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36567966/a-nomogram-model-for-mortality-risk-prediction-in-pulmonary-tuberculosis-patients-subjected-to-directly-observed-treatment-shortcourse-dots
#10
JOURNAL ARTICLE
Yi Xie, Jing Han, Weili Yu, Zhili Hou, Zhen Wan
We analyzed the risk factors of mortality for patients with pulmonary tuberculosis under the Directly Observed Treatment Shortcourse (DOTS) and established a predictive nomogram for the risk of mortality. The retrospective cohort analysis was conducted on the treatment outcomes of 11207 tuberculosis patients in the tuberculosis management information system in Tianjin from 2014 to 2019. Based on the multivariable unconditional logistic regression, we analyzed the risk factors of mortality in patients with pulmonary TB and established the death risk prediction nomogram...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36531535/characteristics-management-and-outcomes-of-community-acquired-pneumonia-due-to-human-rhinovirus-a-retrospective-study
#11
JOURNAL ARTICLE
Ibrahim Bahabri, Abdulaziz Abdulaal, Thamer Alanazi, Sultan Alenazy, Yasser Alrumih, Rakan Alqahtani, Mohammad Bosaeed, Hasan M Al-Dorzi
INTRODUCTION: Human rhinovirus (HRV) can lead to a variety of respiratory illnesses; it is also an uncommon cause of community-acquired pneumonia (CAP). We described the characteristics and outcomes of patients hospitalized for CAP due to HRV. METHODS: We retrospectively studied consecutive adult patients admitted to King Abdulaziz Medical City-Riyadh with CAP due to HRV between 2016 and 2019. The diagnosis was made by respiratory multiplex PCR within 48 hours of hospitalization...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36518817/microrna-101-3p-suppresses-mtor-and-causes-mitochondrial-fragmentation-and-cell-degeneration-in-copd
#12
JOURNAL ARTICLE
Lei Fang, Xinggang Wang, Ming Zhang, Petra Khan, Michael Tamm, Michael Roth
BACKGROUND: Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function. It also modifies mTOR activity, microRNA (miR)-101-3p expression, and mitochondria function. Here, the link between miR-101-3p and mTOR-regulated mitochondria integrity and ASMC deterioration was assessed. METHODS: Disease-specific miR-101-3p expression was determined by RT-PCR in primary ASMC (non-COPD smokers: n  = 6; COPD: n  = 8; healthy: n  = 6)...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36465274/deep-learning-models-to-predict-fatal-pneumonia-using-chest-x-ray-images
#13
JOURNAL ARTICLE
Satoshi Anai, Junko Hisasue, Yoichi Takaki, Naohiko Hara
BACKGROUND AND AIMS: Chest X-ray (CXR) is indispensable to the assessment of severity, diagnosis, and management of pneumonia. Deep learning is an artificial intelligence (AI) technology that has been applied to the interpretation of medical images. This study investigated the feasibility of classifying fatal pneumonia based on CXR images using deep learning models on publicly available platforms. METHODS: CXR images of patients with pneumonia at diagnosis were labeled as fatal or nonfatal based on medical records...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36353447/efficacy-of-intrapleural-or-intrapericardial-injection-of-single-bevacizumab-in-the-treatment-of-lung-cancer-mediated-malignant-effusion
#14
JOURNAL ARTICLE
Dongyun He, Zhihua Guo, Zixian Xie, Yalei Zhang, Qiuhua Deng, Haihong Yang
The usage of bevacizumab for malignant pleural effusion (MPE) or malignant pericardial effusion (MPCE) has attracted increasing interest from researchers, but the precise ways of bevacizumab administration remain unknown. Patients with histologically or cytologically confirmed non-small-cell lung cancer (NSCLC) with MPE or MPCE were enrolled in the study and treated with a low dose of single bevacizumab (100 mg) intrapleurally or intrapericardially injected after the drainage of the effusions. The Lung Cancer Symptom Scale (LCSS), efficacy, and safety of drug administration were used as evaluation parameters in this study...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36353446/cost-effectiveness-of-a-new-outpatient-pulmonology-care-model-based-on-physician-to-physician-electronic-consultation
#15
JOURNAL ARTICLE
José Manuel Álvarez-Dobaño, Malena Toubes, José Ángel Novo-Platas, Francisco Reyes-Santías, Gerardo Atienza, Manuel Portela, Carlos Rábade, Tamara Lourido, Ana Casal, Carlota Rodríguez-García, Vanessa Riveiro, Romina Abelleira, Jorge Ricoy, Nuria Rodríguez-Núñez, Carlos Zamarrón, Felipe Calle, Francisco Gude, Luis Valdés
INTRODUCTION: This study assesses the impact of an electronic physician-to-physician consultation program on the waiting list and the costs of a Pulmonology Unit. MATERIALS AND METHODS: A prepost intervention study was conducted after a new ambulatory pulmonary care protocol was implemented and the capacity of the unit was adopted. In the new model, physicians at all levels of healthcare send electronic consultations to specialists. RESULTS: In the preintervention year (2019), the Unit of Pulmonology attended 7,055 consultations (466 e-consultations and 6,589 first face-to-face visits), which decreased to 6,157 (3,934 e-consultations and 2,223 first face-to-face visits; 12...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36311545/blood-eosinophil-endotypes-across-asthma-and-chronic-obstructive-pulmonary-disease-copd
#16
JOURNAL ARTICLE
Jia-Ying Luo, Hui-An Chen, Yuan-Yu Feng, Ye-Peng Chen, Xiang-Cheng Lei, Shuang-Lin Guo, Xiao-Bin Huang, Zhi-Man Liang, Ning Li, Bao-Qing Sun
BACKGROUND: Eosinophils were common inflammatory cells involved in the occurrence and development of various inflammatory diseases. Multiple recent studies have pointed to the increasingly important role of eosinophils in respiratory diseases. This article aims to compare the expression differences of blood eosinophil counts between asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap (ACO). METHODS: Patients with asthma, COPD, and ACO who were seen in the First Affiliated Hospital of Guangzhou Medical University from January 2012 to June 2019 were included...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36299411/feasibility-of-using-high-resolution-computed-tomography-features-for-invasiveness-differentiation-of-malignant-nodules-manifesting-as-ground-glass-nodules
#17
JOURNAL ARTICLE
Xinyue Chen, Benbo Yao, Juan Li, Chunxiao Liang, Rui Qi, Jianqun Yu
Ground-glass nodule (GGN)-like adenocarcinoma is a special subtype of lung cancer. The invasiveness of the nodule correlates well with the patient's prognosis. This study aimed to establish a radiomic model for invasiveness differentiation of malignant nodules manifesting as ground glass on high-resolution computed tomography (HRCT). Between January 2014 and July 2019, 276 pulmonary nodules manifesting as GGNs on preoperative HRCTs, whose histological results were available, were collected. The nodules were randomly classified into training ( n  = 221) and independent testing ( n  = 55) cohorts...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36276929/a-study-on-cough-sensitivity-and-airway-inflammation-in-patients-with-sinobronchial-syndrome
#18
JOURNAL ARTICLE
Shengyuan Wang, Shanshan Niu, Siwan Wen, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Li Yu, Xianghuai Xu
OBJECTIVE: This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). METHODS: 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS) induced by rhinitis, 33 patients with chronic sinusitis without cough, and 39 healthy controls (HCs) were enrolled between January 2013 and December 2018. All participants underwent a capsaicin cough-sensitivity test and cytology of induced sputum...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36276928/the-nutritional-status-of-chronic-obstructive-pulmonary-disease-exacerbators
#19
JOURNAL ARTICLE
Carina Rôlo Silvestre, Tiago Dias Domingues, Luís Mateus, Maria Cavaco, André Nunes, Ricardo Cordeiro, Teresa Silva Santos, Teresa Falcão, António Domingos
INTRODUCTION: Malnutrition is underdiagnosed in chronic obstructive pulmonary disease. OBJECTIVES: This study aimed to evaluate the nutritional status of COPD patients and the link between dyspnea and nutritional status. METHODS: This longitudinal observational study included patients hospitalized with exacerbated COPD. Nutritional status was assessed using Nutrition Risk Screening 2002, anthropometric, and biochemical assessments, in the first 48 hours of hospitalization...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36262381/effects-of-different-intervention-factors-on-vascular-endothelial-growth-factor-induced-human-airway-smooth-muscle-cell-migration
#20
JOURNAL ARTICLE
Chengtian Lv, Guangyuan Liao, Lichan Wu, Jing Li, Yuanmei Gao
BACKGROUND: Asthma airway remodeling is closely related to the abnormal migration of human airway smooth muscle cells (ASMCs), and vascular endothelial growth factor (VEGF) is involved in the pathophysiological process of asthma. This study aimed to investigate the effect of VEGF on ASMC migration through in vitro cell experiments and to intervene in ASMC migration with different asthma drugs and signaling pathway inhibitors to provide a basis for screening effective drugs for airway remodeling...
2022: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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