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Journals Canadian Respiratory Journal :...

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society

https://read.qxmd.com/read/37808623/the-challenges-of-spirometric-diagnosis-of-copd
#21
REVIEW
Adriana Maldonado-Franco, Luis F Giraldo-Cadavid, Eduardo Tuta-Quintero, Alirio R Bastidas Goyes, Daniel A Botero-Rosas
Chronic obstructive pulmonary disease (COPD) is one of the top causes of morbidity and mortality worldwide. Although for many years its accurate diagnosis has been a focus of intense research, it is still challenging. Due to its simplicity, portability, and low cost, spirometry has been established as the main tool to detect this condition, but its flawed performance makes it an imperfect COPD diagnosis gold standard. This review aims to provide an up-to-date literature overview of recent studies regarding COPD diagnosis; we seek to identify their limitations and establish perspectives for spirometric diagnosis of COPD in the XXI century by combining deep clinical knowledge of the disease with advanced computer analysis techniques...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37645252/the-effects-of-nebulized-inhaled-triptolide-on-airway-inflammation-in-a-mouse-model-of-asthma
#22
JOURNAL ARTICLE
Yafang Miao, Li Wei, Hao Chen, Zeming Zhang, Li Han
Inhalation of nebulized TP has received little attention in the past. Here, we intend to investigate the effect of nebulized inhaled TP on airway inflammation in a mouse model of asthma. 29 SPF BALB/c mice were divided into four groups: blank control (Blk, n  = 5), normal saline (NS, n  = 8), dexamethasone (Dex, n  = 8), and TP ( n  = 8). During the process of sensitization, mice in the three intervention groups were treated with nebulized NS, an injection of Dex, and nebulized triptolide, respectively...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37593092/nocturnal-hypoventilation-in-the-patients-submitted-to-thoracic-surgery
#23
JOURNAL ARTICLE
Maciej Majchrzak, Cyryl Daroszewski, Piotr Błasiak, Adam Rzechonek, Paweł Piesiak, Monika Kosacka, Anna Brzecka
INTRODUCTION: Nocturnal hypoventilation may occur due to obesity, concomitant chronic obstructive pulmonary disease (COPD), obstructive sleep apnea, and/or the use of narcotic analgesics. The aim of the study was to evaluate the risk and severity of nocturnal hypoventilation as assessed by transcutaneous continuous capnography in the patients submitted to thoracic surgery. MATERIALS AND METHODS: The material of the study consisted of 45 obese (BMI 34.8 ± 3...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37547298/patient-and-caregiver-perceptions-of-airway-clearance-methods-used-for-cystic-fibrosis
#24
JOURNAL ARTICLE
Zoe E Kienenberger, Tyler O Farber, Mary E Teresi, Francesca Milavetz, Sachinkumar B Singh, Katie Larson Ode, Theodosia Thoma, Rebecca L Weiner, Kathryn R Burlage, Anthony J Fischer
INTRODUCTION: Cystic Fibrosis Foundation guidelines recommend people with CF perform daily airway clearance. This can be difficult for patients, as some find it time consuming or uncomfortable. Data comparing airway clearance methods are limited. We surveyed patients and their families to understand which methods are preferred and identify obstacles to performing airway clearance. METHODS: We designed a REDCap survey and enrolled participants in 2021. Respondents reported information on airway clearance usage, time commitment, and medication use...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37547297/downregulation-of-vrk1-inhibits-progression-of-lung-squamous-cell-carcinoma-through-dna-damage
#25
JOURNAL ARTICLE
Ning Du, Boxiang Zhang, Yunfeng Zhang
BACKGROUND: Lung squamous cell carcinoma (LUSC) is a common malignancy. And the antitumor effect of bovine pox virus-associated kinase 1 (VRK1) is becoming a hot research topic. METHODS: VRK1 expression and prognosis in LUSC were analyzed using the GEPIA database. The expression of VRK1 mRNA was detected in 25 LUSC clinical tissue samples by RT-PCR. VRK1 shRNA was transfected into LUSC NCI-H520 and SK-MES-1 cell lines to interfere with VRK1 expression, and the efficiency of VRK1 shRNA interference was detected by the western blot...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37426578/high-flow-nasal-oxygen-versus-noninvasive-ventilation-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-patients-a-meta-analysis-of-randomized-controlled-trials
#26
JOURNAL ARTICLE
Yanping Du, Huaping Zhang, Zhiyi Ma, Jun Liu, Zhiyong Wang, Meixia Lin, Fayu Ni, Xi Li, Hui Tan, Shifan Tan, Yanling Chai, Xiangzhu Zhong
BACKGROUND: High-flow nasal cannula (HFNC) can be used in stable chronic obstructive pulmonary disease (COPD) patients, but the effect of HFNC on clinical outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is still uncertain. METHODS: We searched electronic literature databases for randomized controlled trials (RCTs) comparing HFNC with noninvasive ventilation (NIV) in hypercapnic patients with AECOPD. The primary endpoint of this meta-analysis was PaCO2 , PaO2, and SpO2 ...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37388902/yap1-as-a-novel-negative-biomarker-of-immune-checkpoint-inhibitors-for-egfr-mutant-non-small-cell-lung-cancer
#27
JOURNAL ARTICLE
Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun
BACKGROUND: Immune checkpoint inhibitors (ICIs) have become a standard care in non-small-cell lung cancer (NSCLC). However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed to clarify the potential role of Yes1-associated transcriptional regulator (YAP1) in ICIs treatment for EGFR-mutant NSCLC population. METHODS: All the clinical data of NSCLC were downloaded from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) for GSE11969 and GSE72094...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37332881/predictive-factors-of-nonmalignant-pathological-diagnosis-and-final-diagnosis-of-ultrasound-guided-cutting-biopsy-for-peripheral-pulmonary-diseases
#28
JOURNAL ARTICLE
Qing Li, Li Zhang, Xinhong Liao, Yanfen Zhong, Zhixian Li
This study aimed to explore the predictive factors of nonmalignant pathological diagnosis and final diagnosis of ultrasound-guided cutting biopsy for peripheral pulmonary diseases. A total of 470 patients with peripheral lung disease diagnosed as nonmalignant by ultrasound-guided cutting biopsy in the First Affiliated Hospital of Guangxi Medical University from January 2017 to May 2020 were included. Ultrasound biopsy was performed to determine the correctness of pathological diagnosis. Independent risk factors of malignant tumor were predicted by multivariate logistic regression analysis...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37275320/blood-eosinophil-count-as-a-predictive-biomarker-of-chronic-obstructive-pulmonary-disease-exacerbation-in-a-real-world-setting
#29
JOURNAL ARTICLE
Moegi Komura, Tadashi Sato, Yohei Suzuki, Hitomi Yoshikawa, Naoko Arano Nitta, Mika Hayashi, Eriko Kuwasaki, Kimiko Horikoshi, Toshihiko Nishioki, Mikiko Mori, Yuzo Kodama, Shinichi Sasaki, Kazuhisa Takahashi
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death, and COPD exacerbation worsens the prognosis. Eosinophilic airway inflammation is a COPD phenotype that causes COPD exacerbation and is correlated with peripheral blood eosinophil count. We analyzed real-world data of COPD patients to assess the risk factors of COPD exacerbation focusing on blood eosinophils. MATERIALS AND METHODS: Patients with COPD who visited our hospital between January 1, 2018, and December 31, 2018, were recruited, and their background information, spirometry data, laboratory test results, and moderate-to-severe exacerbation events during the one-year follow-up period were collected from the electronic medical records and analyzed...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37207250/prognostic-risk-factors-of-30-day-death-in-traumatic-lower-limb-fracture-patients-with-acute-pulmonary-embolism-a-single-center-retrospective-study
#30
JOURNAL ARTICLE
Huanhuan Li, Yijun Yu, Yuting Wang, Qian Zhang, Ye Gu
BACKGROUND: To explore the prognostic risk factors of 30-day death in patients with traumatic lower limb fracture (TLLF) complicated with acute pulmonary embolism (APE). METHODS: 295 consecutive TLLF patients diagnosed as APE according to pulmonary artery CT angiography, hospitalized in our hospital from January 2017 to December 2021, were included in this study. Patients were divided into nonsurvival group and survival group according to 30-day follow-up results...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37200921/mcp-4-and-eotaxin-3-are-novel-biomarkers-for-chronic-obstructive-pulmonary-disease
#31
JOURNAL ARTICLE
Chun Fang, Baoguo Kang, Pan Zhao, Jing Ran, Lifang Wang, Lingqiong Zhao, Hangyu Luo, Ling Tao
The aim of our study was to examine the production of monocyte chemoattractant protein (MCP-4) and eotaxin-3 during the onset and progression of COPD. The expression levels of MCP-4 and eotaxin-3 were evaluated in COPD samples and healthy controls using immunostaining and ELISA. The relationship between the clinic pathological features in the participants and the expression of MCP-4 and eotaxin-3 were evaluated. The association of MCP-4/eotaxin-3 production in COPD patients was also determined. The results revealed enhanced production of MCP-4 and eotaxin-3 in COPD patients especially the cases with AECOPD in both bronchial biopsies and bronchial washing fluid samples...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37181158/safety-and-risk-factors-of-needle-thoracentesis-decompression-in-tension-pneumothorax-in-patients-over-75%C3%A2-years-old
#32
JOURNAL ARTICLE
Yanhu Wang, Lei Wang, Cheng Chen, Yifan Que, Yinyi Li, Jiang Luo, Ming Yin, Miao Lv, Guogang Xu
BACKGROUND: There are very few professional recommendations or guidelines on the needle thoracentesis decompression (NTD) for the tension pneumothorax in the elderly. This study aimed to investigate the safety and risk factors of tension pneumothorax NTD in patients over 75 years old based on CT evaluation of the chest wall thickness (CWT). METHODS: The retrospective study was conducted among 136 in-patients over 75 years old. The CWT and closest depth to vital structure of the second intercostal space at the midclavicular line (second ICS-MCL) and the fifth intercostal space at the midaxillary line (fifth ICS-MAL) were compared as well as the expected failure rates and the incidence of severe complications of different needles...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37153722/association-of-upon-diagnosis-blood-eosinophilic-count-with-frequency-and-severity-of-annual-exacerbation-in-chronic-obstructive-pulmonary-disease-a-prospective-longitudinal-analysis
#33
JOURNAL ARTICLE
Arda Kiani, Fatemehsadat Rahimi, Siamak Afaghi, Maryam Paat, Mohammad Varharam, Mehdi Kazempour Dizaji, Maryam Dastoorpoor, Atefeh Abedini
INTRODUCTION: There is a controversy regarding the relationship between blood eosinophil count and COPD exacerbation. We aimed to determine whether peripheral eosinophils upon COPD diagnosis could affect the frequency and severity of annual acute exacerbation of COPD (AECOPD). METHODS: This prospective study was conducted on 973 newly diagnosed COPD patients who were under 1-year follow-up in a pulmonology center in Iran. The Cox proportional model, polynomial regression, and receiver operator characteristic curves were conducted to evaluate the impact of the eosinophil levels on AECOPD...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37096167/poor-outcome-and-mortality-in-patients-with-lower-lung-dominant-sarcoidosis
#34
JOURNAL ARTICLE
Kazunobu Tachibana, Masanori Akira, Toru Arai, Chikatoshi Sugimoto, Seiji Hayashi, Yoshikazu Inoue
BACKGROUND: Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality. METHODS: We retrospectively reviewed clinical data including the pulmonary function tests of 108 consecutive patients with pulmonary sarcoidosis pathologically confirmed by lung and/or mediastinal lymph node biopsy from 2004 to 2014 from our database...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37096166/high-flow-nasal-cannula-versus-noninvasive-ventilation-in-aecopd-patients-with-respiratory-acidosis-a-retrospective-propensity-score-matched-study
#35
COMPARATIVE STUDY
Meng Wang, Feifan Zhao, Lina Sun, Ying Liang, Wei Yan, Xiaoyan Sun, Qingtao Zhou, Bei He
BACKGROUND: Limited data are available about the clinical outcomes of AECOPD patients with respiratory acidosis treated with HFNC versus NIV. METHODS: We conducted a retrospective study to compare the efficacy of HFNC with NIV as initial ventilation support strategy in AECOPD patients with respiratory acidosis. Propensity score matching (PSM) was implemented to increase between-group comparability. Kaplan-Meier analysis was utilized to evaluate differences between the HFNC success, HFNC failure, and NIV groups...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/37020746/correlation-between-ct-score-and-kl-6-a-severity-assessing-in-juvenile-dermatomyositis-associated-interstitial-lung-disease
#36
JOURNAL ARTICLE
Chi Wang, Jun Hou, Jianming Lai, Ran Tao, Yang Yang, Wenhan Hao, Xinyu Yuan, Yuchun Yan
BACKGROUND: There is no radiological measurement to estimate the severity of pediatrics juvenile dermatomyositis (JDM) with interstitial lung disease (ILD). We validated the effectiveness of CT scoring assessment in JDM patients with ILD. AIM: To establish a CT scoring system and calculate CT scores in JDM patients with ILD and to determine its reliability and the correlation with Krebs von den Lungen-6 (KL-6). METHODS: The study totally enrolled 46 JDM-ILD patients and 16 JDM without ILD (non-ILD, NILD) patients...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36960314/serum-bilirubin-levels-and-disease-severity-in-patients-with-pneumoconiosis
#37
JOURNAL ARTICLE
You-Fan Peng, Jun-Hua Deng, Xiao-Ying Huang, Qing-Song Zhang
AIM: To investigate the association between serum bilirubin and disease severity in patients with pneumoconiosis. METHODS: The study comprised 45 patients with pneumoconiosis retrospectively; all pneumoconiosis patients were classified into I, II, and III stage according to the radiological severity. RESULTS: Serum direct bilirubin levels were significantly lower in III stage pneumoconiosis patients than those in I/II stage ( p  = 0...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817552/ild-gap-combined-with-the-charlson-comorbidity-index-score-ild-gapc-as-a-prognostic-prediction-model-in-patients-with-interstitial-lung-disease
#38
JOURNAL ARTICLE
Hiroaki Fujii, Yu Hara, Yusuke Saigusa, Yoichi Tagami, Kota Murohashi, Ryo Nagasawa, Ayako Aoki, Ami Izawa, Kenichi Seki, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi, Takeshi Kaneko
BACKGROUND: The ILD-GAP scoring system has been widely used to predict the prognosis of patients with interstitial lung disease (ILD). The ability of the ILD-GAP scoring system combined with the Charlson Comorbidity Index score (CCIS) (ILD-GAPC) to predict ILD prognosis was investigated. METHODS: In ILD patients, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), collagen vascular disease-related interstitial pneumonia (CVD-IP), chronic hypersensitivity pneumonitis (CHP), and unclassifiable ILD (UC-ILD), treated between April 2013 and April 2017, the relationships between baseline clinical parameters, including age, sex, CCIS, ILD diagnosis, pulmonary function test results, and disease outcomes, were retrospectively assessed, and the ability to predict prognosis was compared between the ILD-GAP and ILD-GAPC models, respectively...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817551/corrigendum-to-clinical-characteristics-of-asymptomatic-patients-with-sars-cov-2-in-zhejiang-an-imperceptible-source-of-infection
#39
Wei Dai, Xinmiao Chen, Xiaoting Xu, Zhefeng Leng, Wenwen Yu, Hui Lin, Huiying Li, Jie Lin, Zhangwei Qiu, Yuanrong Dai
[This corrects the article DOI: 10.1155/2020/2045341.].
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/36817550/validation-of-sequential-rox-index-score-beyond-12%C3%A2-hours-in-predicting-treatment-failure-and-mortality-in-covid-19-patients-receiving-oxygen-via-high-flow-nasal-cannula
#40
JOURNAL ARTICLE
Dimitris Basoulis, Pantelis Avramopoulos, Maria Aggelara, Georgios Karamanakos, Pantazis-Michail Voutsinas, Amalia Karapanou, Mina Psichogiou, Michalis Samarkos, Foteini Ntziora, Nikolaos V Sipsas
BACKGROUND: High-flow nasal cannula (HFNC) is an oxygen delivery method shown to reduce the risk of intubation and mortality in patients with type 1 respiratory failure. The ROX-index score can predict HFNC failure. This study aims to evaluate sequential ROX-index assessments as predictors of HFNC failure and mortality. METHODS: Prospective observational single-center study including all adult patients with positive SARS-CoV-2 PCR placed under HFNC from 1st November 2020 to 31st May 2021, and patients with hemodynamic instability or unable to tolerate HFNC were excluded...
2023: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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