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Archives of Medical Research

Roberto Garcia, Jaime Burkle
Cardiovascular disease (CVD) is the leading cause of death in the world. According to the World Health Organization, an estimated 17.9 million people died from CVD in 2016, representing 31% of all global deaths. Of these deaths, 5% are due to myocardial infarction and stroke. Dyslipidemia is known as the major risk factor of atherosclerotic cardiovascular disease. With current therapies, about 60% of high-risk CVD patients do not achieve LDL-C goals, and in patients with familiar hypercholesterolemia (FH) at maximum intensity statin treatment, only 20% achieve LDL-C goals...
February 7, 2019: Archives of Medical Research
Fabio Salamanca-Gómez
No abstract text is available yet for this article.
February 4, 2019: Archives of Medical Research
Gabriela Borrayo-Sánchez, José Ramón González-Juanatey
No abstract text is available yet for this article.
February 1, 2019: Archives of Medical Research
Gabriela Borrayo-Sánchez, Martín Rosas-Peralta, Erick Ramírez-Arias, Guillermo Saturno-Chiu, Joel Estrada-Gallegos, Rodolfo Parra-Michel, Hugo R Hernandez-García, Ernesto A Ayala-López, Rafael Barraza-Felix, Andrés García-Rincón, Débora Adalid-Arellano, Guillermo Careaga-Reyna, José L Lázaro-Castillo, Lidia E Betancourt-Hernández, Rocío Camacho-Casillas, Martha Hernández-Gonzalez, Germán Celis-Quintal, Beatriz Villegas-González, Marco Hernández-Carrillo, Zaria M Benitez Arechiga, Abelardo Flores-Morales, Ana C Sepúlveda-Vildosola
INTRODUCTION: Mexico is the country with the highest mortality due to acute myocardial infarction in adults older than 45 years old according to the OECD (28 vs. 7.5% of the average). The first real-world study, RENASCA IMSS, showed a high-risk population at 65%, but 50% without reperfusion strategies. The aim was to describe the clinical presentation, treatment, and outcomes of acute coronary syndromes at the IMSS. METHODS: RENASCA IMSS is a nation-wide, prospective, longitudinal-cohort study...
February 1, 2019: Archives of Medical Research
Alfonso Farías-Basulto, Héctor Ramón Martínez-Ramírez, Erika Fabiola Gómez-García, Alfonso Martín Cueto-Manzano, Laura Cortés-Sanabria, Luis Eduardo Hernández-Ramos, Guadalupe Ramírez-López, Francisco Mendoza-Carrera
INTRODUCTION: Diabetic nephropathy is a leading cause of chronic kidney disease (CKD). In diabetes, changes in serum levels of both soluble alpha Klotho (sKL) and fibroblast growth factor 23 (FGF-23) have been associated with CKD progression. OBJECTIVE: To evaluate the associations of circulating levels of sKL and FGF-23 with the presence of early nephropathy (EN) in diabetic patients. METHODS: A cross-sectional study in 136 Mexicans with type 2 diabetes mellitus (T2DM)...
February 1, 2019: Archives of Medical Research
Brice Blum, Leanne Brechtel, Thomas Nathaniel
BACKGROUND: The benefits of a special stroke care unit (SSCU) over a non-specialized stroke care unit (NSSCU) is well documented in the literature. However, there are concerns that the benefits seen in the SSCU do not consider clinical risk factors that affect thrombolysis therapy. METHOD: Retrospective data were collected from a stroke registry between January 1, 2010-June 30, 2016. Univariate analysis determined differences in exclusion criteria between the SSCU and NSSCU, while multivariable binary logistic regression adjusted for confounding variables...
January 12, 2019: Archives of Medical Research
Nancy S Saad, Mohammad T Elnakish, Amany A E Ahmed, Paul M L Janssen
Heart failure (HF) is a clinical syndrome characterized by impaired ability of the heart to fill or eject blood. HF is rather prevalent and it represents the foremost reason of hospitalization in the United States. The costs linked to HF overrun those of all other causes of disabilities, and death in the United States and all over the developed as well as the developing countries which amplify the supreme significance of its prevention. Protein kinase (PK) A plays multiple roles in heart functions including, contraction, metabolism, ion fluxes, and gene transcription...
January 11, 2019: Archives of Medical Research
Rene Arredondo-Hernandez, Patricia Orduña-Estrada, Yolanda Lopez-Vidal, Samuel Ponce de Leon-Rosales
The lack of comprehensive understanding of the way immunity backfires on incidence and complications has made Clostridium difficile infection (CDI), the infectious disease of our times, as evidenced by in the parallel course it follows along epidemic of chronic degenerative diseases. Within these ailments, if as suspected the main effect of Clostridium difficile A and B toxins depends on inflammation, then aberrant immune function due to antibiotics would explain IBD triggering after treatment but also, the higher incidence and mortality surrounding disorders that are inflammatory and/or that show abatement of neutrophils...
January 4, 2019: Archives of Medical Research
Moisés Rodríguez-Mañero, Lilian Grigorian-Shamagian, Gregorio Rábago, Charigan Abou-Jokh, Belen Álvarez, María Brion, José Ramón González-Juanatey
Heart failure (HF) is a progressively debilitating disease that considerably decreases the life expectancy and quality of life. It has become an important area of focus since it remains one of the most common reasons for admission in patients over the age of 65. Importantly, the incidence of HF has not declined within the past 20 years, but the survival after onset has increased in younger patients and men. This has been in part due to the growing interest in therapies that may decrease morbidity, mortality, along with the substantial health care expenditures associated with the disease...
December 31, 2018: Archives of Medical Research
Recep Bedir, Levent Tumkaya, Tolga Mercantepe, Adnan Yilmaz
BACKGROUND: The widespread use by young people of modern communication devices such as mobile phones means that they are particularly exposed to electromagnetic fields (EMF) and other problems. However, few studies have researched the effects of long-term exposure to EMF in the kidney. We therefore investigated oxidative stress and apoptosis in long-term exposure to 2100 megahertz (MHz) in a rat model. MATERIALS AND METHODS: Twenty-four Sprague Dawley rats were divided into a control group (n = 8, no EMF exposure), a group exposed to 2100 MHz for 6 h for 30 d (n = 8), and a group exposed to 2100 MHz for12 h for 30 d (n = 8)...
December 29, 2018: Archives of Medical Research
Jian Zhao, Yuze Chen, Fang Liu, Mingdi Yin
MiRNA-143 overexpression is related to upregulated blood glucose level in diabetic mice, and downregulated miRNA-143 has been observed in several types of cancers, indicating its role as a tumor suppression miRNA. Glucose metabolism plays pivotal roles in tumor growth. Therefore, miRNA-143 may target glucose metabolism to inhibit tumor growth. Up to now, the functionality of miRNA-143 in colon cancer is still largely unknown. Our study was carried out to investigate the role of miRNA-143 in colon cancer and to explore the interactions between miRNA-143 and glucose uptake pathway...
December 27, 2018: Archives of Medical Research
Angélica L Sánchez-López, Genaro Gabriel Ortiz, Fermín P Pacheco-Moises, Mario A Mireles-Ramírez, Oscar K Bitzer-Quintero, Daniela L C Delgado-Lara, Luis J Ramírez-Jirano, Irma E Velázquez-Brizuela
Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system (CNS). Neuroinflammation and oxidative stress are involved in the pathogenesis of MS, promoting tissue damage and demielinization. Current research findings suggest that melatonin has antioxidant and neuroprotective effects. The aim of this study was to evaluate the efficacy of melatonin on serum pro-inflammatory cytokines and oxidative stress markers in relapsing-remitting multiple sclerosis (RRMS)...
December 27, 2018: Archives of Medical Research
Juan Salazar, Milagros Rojas, Cristobal Espinoza
From centuries ago cannabis has been known as a botanic product with several properties, with medical use in the ancient world. Nowadays, it is recognized as the active component of marijuana, the drug with the highest rates of illicit use and abuse worldwide according to data provided by the World Health Organization. A huge debate has emerged in these past years with the growing interest to employ cannabis-based products with therapeutic purposes, a strategy that has increased in various European countries, Canada and more than half of the states that conform the United States, simultaneously with an important increase of flexibility in laws and regulations regarding the recreational use of this substance, especially in North America...
December 27, 2018: Archives of Medical Research
Yanqiu Xing, Congcong Liu, Huanliang Wang, Xia Zhang, Yan Wang, Xizan Yue, Zhonggang Li, Xin Wang, Wenhua Zhang
Nicorandil, the first clinically applied ATP-sensitive K+ channel (K+ ATP) opener with nitrate property, has demonstrated cardioprotective effects in patients with multiples of heart diseases. However, it is unknown whether nicorandil has effects on left ventricular (LV) remodeling in rats with ischemic heart failure and the potential mechanisms remain unclear. In this study, we investigated the effects of nicorandil on cardiac function, LV remodeling, and Bax expression in myocardium of LV in rats with ischemic heart failure...
December 20, 2018: Archives of Medical Research
Hongwei Tan, Zhisong Chen, Fei Chen, Yian Yao, Yan Lai, Wenjun Xu, Xuebo Liu
BACKGROUND: As shown in clinical and experimental studies, atrial fibrosis is an important mechanism for the occurrence and development of atrial fibrillation, the most common arrhythmia in the clinic with high disability and mortality. Some studies have shown the possible involvement of tryptase, a protease released by mast cells, in the fibrosis of heart tissues, but the effect and mechanism of tryptase on extracellular matrix (ECM) remodeling and atrial fibrosis is not clear yet. MATERIAL AND METHOD: This study evaluated the effects of tryptase on the proliferation, migration, ECM remodeling and the balance between matrix metalloproteinase (MMP)/tissue inhibitor of metalloproteinase (TIMP) of fibroblasts by in vitro culture of atrial fibroblasts...
December 20, 2018: Archives of Medical Research
Sergio A Castillo-Torres, Ingrid E Estrada-Bellmann, Andrew J Lees
BACKGROUND: The vertiginous pace with which modern medicine advances, can seem overwhelming to students and young doctors. AIM OF THE STUDY: To reappraise an oration by William Osler delivered to medical students at the point of their graduation. METHODS: Narrative review. RESULTS: Osler emphasised the Art of Detachment, the Virtue of Method, the Quality of Thoroughness and the Grace of Humility, which he considers the basic pillars on which a successful medical practice is achieved, Osler's words serve as a guiding light for physicians struggling with the demands of twenty first century medicine...
December 19, 2018: Archives of Medical Research
Gabriela Borrayo Sanchez, Martín Rosas Peralta, Olga Georgina Martínez Montañez, Samuel Justiniano Cordero, German Fajardo Dolci, Ana Carolina Sepulveda Vildosola, Jesus Arriaga Dávila
The cardiovascular diseases (CVDs) have a growing impact over the world mortality, affecting mostly low and middle-income countries. This is due to changes in the population pyramid and the increase in unhealthy lifestyles that predispose the global population to cardiovascular risk factors such as overweight, obesity, smoking, hypertension, diabetes, dyslipidemias and metabolic syndrome. Ischemic heart disease and the cerebral vascular event remain the first causes of death reported by the World Health Organization (WHO) for more than a decade...
December 19, 2018: Archives of Medical Research
Rong Yan, Chun-Yan Niu, Yu Tian
OBJECTIVE: To investigate interaction between autophagy and PKC-ε in lipid metabolism of NAFLD cell models. METHODS: HL-7702 cells and SK-HEP-1 cells were cultured in vitro as NAFLD cell models and treated with RAPA to induce autophagy. 3-MA was used to inhibit cell autophagy. And HL-7702 and SK-HEP-1 cell were ordinary cultured as control groups. Cell viability was determined by MTT colorimetric assay. The levels of TG, TC and PKC-ε were detected by ELISA...
December 17, 2018: Archives of Medical Research
Maria Nieves Garcia-Casal, Sant-Rayn Pasricha, Ricardo X Martinez, Lucero Lopez-Perez, Juan Pablo Peña-Rosas
BACKGROUND: Serum or plasma ferritin concentration is recommended by WHO as a biomarker to assess iron status in individuals and populations. METHODS: A systematic review was undertaken to summarise the evidence for ferritin reflecting iron status and to assess the cut-off points in different populations. Electronic databases were searched for studies evaluating ferritin concentrations compared against bone marrow aspirates for iron deficiency and to liver biopsies for risk of iron overload...
December 17, 2018: Archives of Medical Research
Mauro Feola, Marzia Testa, Cinzia Ferreri, Marco Cardone, Mario Sola, Sara Ariotti, Gian LucaRosso
No abstract text is available yet for this article.
December 13, 2018: Archives of Medical Research
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