Héctor Vargas-Calderón, Emmanuel Ortega-Robles, Luisa Rocha, Philipp Yu, Oscar Arias-Carrión
BACKGROUND: Toll-like receptors (TLRs) play a critical role in initiating the innate immune response to infection or injury. Recent studies have uncovered their intriguing functions as moonlighting proteins involved in various biological processes, including development, learning, and memory. However, the specific functions of individual TLRs are still largely unknown. AIMS: We investigated the effects of TLR3 and TLR9 receptor deficiency on motor, cognitive, and behavioral functions during development using genetically modified male mice of different ages...
March 22, 2024: Archives of Medical Research
Tanya Mohammadi, Babak Mohammadi
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Screening the general population for this may help to select appropriate diagnostic and preventive measures before disease progression. AIMS: We aimed to develop a screening method to identify patients with NAFLD in the general population. METHODS: We analyzed cross-sectional data from a large Japanese study of NAFLD. Principal component analysis was used to analyze the data...
March 21, 2024: Archives of Medical Research
M Azhar Hussain, Rizwan Qaisar, Asima Karim, Firdos Ahmad, Fabio Franzese, Saad M Alsaad, Abeer A Al-Masri, Shaea A Alkahtani
OBJECTIVES: Early diagnosis of Parkinson's disease (PD) is critical for optimal treatment. However, the predictive potential of physical and mental health in PD is poorly characterized. METHODS: We evaluated the potential of multiple demographic, physical, and mental factors in predicting the future onset of PD in older adults aged 50 years or older from 15 European countries. Individual study participants were followed over four waves of the Survey of Health, Ageing, and Retirement in Europe (SHARE) from 2013-2020...
March 21, 2024: Archives of Medical Research
Perla Graciela Rodríguez-Gutiérrez, Teresita de Jesús Hernández-Flores, Paola Montserrat Zepeda-Olmos, Christian Daniel Reyes-Rodríguez, Kiabeth Robles-Espinoza, Ulises Solís-Gómez, Juan Ramón González-García, María Teresa Magaña-Torres
INTRODUCTION: In Mexico, familial hypercholesterolemia (FH) is underdiagnosed, but population screening in small communities where at least one homozygous patient has already been detected results in a useful and inexpensive approach to reduce this problem. Considering that we previously reported nine homozygous cases from the state of Oaxaca, we decided to perform a population screening to identify patients with FH and to describe both their biochemical and genetic characteristics. METHODS: LDL cholesterol (LDLc) was quantified in 2,093 individuals from 11 communities in Oaxaca; either adults with LDLc levels ≥170 mg/dL or children with LDLc ≥130 mg/dL were classified as suggestive of FH and therefore included in the genetic study...
March 20, 2024: Archives of Medical Research
Carlos A Ibáñez, Francisco Correa, Gabriela Lira-León, Luis A Reyes-Castro, Francisco Javier Roldán, Alejandro Silva-Palacios, Mabel Buelna-Chontal, Guadalupe L Rodríguez-González, Peter W Nathanielsz, Cecilia Zazueta, Elena Zambrano
Maternal obesity predisposes offspring (F1) to cardiovascular disease. To evaluate basal heart function and ischemia-reperfusion (IR) responses in F1 males and females of obese mothers, female Wistar rats (F0) were fed chow or an obesogenic (MO) diet from weaning through pregnancy and lactation. Non-sibling F1 males and females were weaned to chow at postnatal day (PND) 21 and euthanized at PND 550. Offspring of MO mothers (MOF1) rarely survive beyond PND 650. Hearts were immediately isolated from euthanized F1s and subjected to 30 min ischemia with 20 min reperfusion...
March 15, 2024: Archives of Medical Research
Zimri Aziel Alvarado-Ojeda, Celeste Trejo-Moreno, Eduardo Ferat-Osorio, Marisol Méndez-Martínez, Gladis Fragoso, Gabriela Rosas-Salgado
Fatty liver is a multifactorial disease characterized by excessive accumulation of lipids in hepatocytes (steatosis), insulin resistance, oxidative stress, and inflammation. This disease has a major public health impact because it is the first stage of a chronic and degenerative process in the liver that can lead to steatohepatitis, cirrhosis, and liver cancer. Although this disease is mainly diagnosed in patients with obesity, type 2 diabetes mellitus, and dyslipidemia, recent evidence indicates that vasoactive hormones such as angiotensin II (ANGII) not only promote endothelial dysfunction (ED) and hypertension, but also cause fatty liver, increase adipose tissue, and develop a pro-steatotic environment characterized by a low-grade systemic pro-inflammatory and pro-oxidant state, with elevated blood lipid levels...
March 15, 2024: Archives of Medical Research
Juan Carlos Fernández-Macías, Laura Sherell Marín-Jauregui, Karen Beatriz Méndez-Rodríguez, Ana Patricia Huerta-Rodríguez, Francisco Javier Pérez-Vázquez
BACKGROUND: Cardiovascular disease (CVD) is one of the main causes of death and disability worldwide. The etiology of CVD is often associated with multiple risk factors, with environmental factors receiving considerable attention. Individuals with precarious jobs are among the groups most affected by chronic exposure to environmental pollutants. AIM: This study aimed to evaluate occupational exposure to heavy metals among individuals in precarious job settings and investigate atherogenic indices as biomarkers of cardiovascular risk...
March 13, 2024: Archives of Medical Research
María de la Luz Villela-Torres, María-Del-Carmen Prado-Uribe, Marcela Ávila Díaz, Héctor Quezada Pablo, Elizabeth Soria-Castro, Nuria Esturau Escofet, Catalina Elizabeth Flores Maldonado, Ramón Paniagua
INTRODUCTION: Uremic toxicity changes the gut structure and permeability, allowing bacterial toxins to translocate from the lumen to the blood during chronic kidney failure (CKD). Clinical fluid overload and tissue edema without uremia have similar effects but have not been adequately demonstrated and analyzed in CKD. AIMS: To investigate the effect of sodium intake on the plasma concentration of gut-derived uremic toxins, indoxyl sulfate (IS), and p-cresyl sulfate (pCS) and the expression of genes and proteins of epithelial gut tight junctions in a rat model of CKD...
March 13, 2024: Archives of Medical Research
Abdallah S Mohamed, Afrah F Salama, Magdy A Sabaa, Eman Toraih, Rami M Elshazli
BACKGROUND: The relationship between GEMIN4 genetic variants and cancer, especially bladder carcinoma (BLCA), has been explored without conclusive results. This study aims to elucidate the link between GEMIN4 polymorphisms and BLCA susceptibility through genetic analyses, bioinformatics, and molecular dynamics (MD) simulations. METHODS: A cohort of 249 participants (121 BLCA patients and 128 unrelated controls) was enrolled. PCR was employed for allelic discrimination of GEMIN4 variants, followed by subgroup stratification, haplotype analyses, structural prediction using the AlphaFold2 prediction tool, subsequent MD simulations, structural analysis, and residue interaction mapping using Desmond, UCSF ChimeraX, and Cytoscape softwares...
February 23, 2024: Archives of Medical Research
Alva Belen Morales-Villar, Jorge Maldonado-Hernández, Nelson Eduardo Álvarez-Licona, Mónica Ivette Piña-Aguero, Salvador Villalpando-Hernández, Ricardo Martín Robledo-Pérez, Ismael Díaz-Rangel, María de Lourdes Barbosa-Cortés, Benjamín-Armando Núñez-García
BACKGROUND AND AIMS: Vitamin D deficiency is a global health problem. The determinants of this deficiency have not been evaluated in developing countries such as Mexico. Thus, this study aimed to determine vitamin D intake and sun exposure and its relationship with plasma concentrations of 25-hydroxyvitamin D -25(OH)D- in young adults from Mexico City. METHODS: One hundred fifty five urban adult subjects were enrolled during 2017 and 2018. Sociodemographic, anthropometric, and clinical data, vitamin D intake, and sun exposure habits were collected...
February 17, 2024: Archives of Medical Research
Heladia García, Miguel Angel Villasis-Keever, Georgina Zavala-Vargas, Juan Carlos Bravo-Ortiz, Ayari Pérez-Méndez, Alberto Escamilla-Núñez
BACKGROUND: Retinopathy of prematurity (ROP) is a vasoproliferative disease of the retina that occurs in premature infants. The prevalence of ROP reported so far is inconsistent. AIM: To conduct a systematic review to describe the trend of ROP prevalence between 1985 and 2021, and to determine the influence of countries' economic conditions on ROP prevalence. METHODS: We searched PubMed, Embase, and Google Scholar for studies published between January 1985 and December 2021 using the following MeSH terms: "retinopathy of prematurity", "ROP", "incidence", and "prevalence"...
February 15, 2024: Archives of Medical Research
Anshul Panjeta, Khushpreet Kaur, Rinkle Sharma, Indu Verma, Simran Preet
BACKGROUND AND AIM: The increasing dilemma of multidrug-resistant cancer cells in response to currently available chemotherapeutic drugs and their associated side effect(s), calls for the investigation of alternative anticancer advances and molecules. Therefore, the present study aimed to elucidate the combinatorial potential against colon cancer of human defensin 5 in combination with 5-fluorouracil (5-FU), and against 5-FU resistant colon tumor cells. METHODS: The in vivo combinatorial potential of HD-5 with 5-FU was elucidated in terms of tumor morphometrics, apoptosis assay, surface morphology histology of the colon(s), and transcriptional alterations...
February 7, 2024: Archives of Medical Research
Sandra Calixto-Tlacomulco, Ismael Luna-Reyes, Blanca Delgado-Coello, Roxana Gutiérrez-Vidal, Juan Pablo Reyes-Grajeda, Jaime Mas-Oliva
BACKGROUND: The nasal vaccine HB-ATV-8 has emerged as a promising approach for NAFLD (non-alcoholic fatty liver disease) and atherosclerosis prevention. HB-ATV-8 contains peptide seq-1 derived from the carboxy-end of the Cholesteryl Ester Transfer Protein (CETP), shown to reduce liver fibrosis, inflammation, and atherosclerotic plaque formation in animal models. Beyond the fact that this vaccine induces B-cell lymphocytes to code for antibodies against the seq-1 sequence, inhibiting CETP's cholesterol transfer activity, we have hypothesized that beyond the modulation of CETP activity carried out by neutralizing antibodies, the observed molecular effects may also correspond to the direct action of peptide seq-1 on diverse cellular systems and molecular features involved in the development of liver fibrosis...
January 31, 2024: Archives of Medical Research
Raffaella Mormile
No abstract text is available yet for this article.
January 30, 2024: Archives of Medical Research
Bin Yu, Yuqi Yang, Lingna Zhou, Qiuwei Wang
PURPOSE: Analysis of four newborn screening modes using newborn genomic sequencing (nGS) and traditional biochemical screening (TBS). METHODS: Prospective clinical study with a total of 1,012 newborn samples from retrospective TBS. Three independent groups performed the study under strict double-blind conditions according to the screening modes: independent biochemical (IBS), independent NeoSeq (INS), sequential (SS), and combined (CS) screening. Using targeted sequencing, the NeoSeq panel included 154 pathogenic genes covering 86 diseases...
January 30, 2024: Archives of Medical Research
Alfredo Juarez-Saldivar, Rogelio Gómez-Escobedo, Gerardo Corral-Ruiz, Karla Fabiola Chacón-Vargas, Vanessa Horta-Montaño, Luvia Sanchez-Torres, Lenci K Vazquez-Jimenez, Benjamín Nogueda-Torres, Gildardo Rivera
BACKGROUND: Chagas disease and cutaneous leishmaniasis, two parasitic diseases caused by Trypanosoma cruzi (T. cruzi) and Leishmania mexicana (L. mexicana), respectively, have a major global impact. Current pharmacological treatments for these diseases are limited and can cause severe side effects; thus, there is a need for new antiprotozoal drugs. METHODS: Using molecular docking, this work describes a structure-based virtual screening of an FDA-approved drug library against Trypanosoma cruzi and Leishmania mexicana glycolytic enzyme triosephosphate isomerase (TIM), which is highly conserved in these parasites...
January 29, 2024: Archives of Medical Research
Graciela Cárdenas, María Chávez-Canales, Ana María Espinosa, Antonio Jordán-Ríos, Daniel Anica Malagon, Manlio Fabio Márquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos, Rosa María Wong-Chew, Luis Esteban Ramirez González, Karent Ibet Cresencio, Enrique García Velázquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernández-Ruiz, María Luisa Hernández-Medel, Mireya León-Hernández, Karen Medina Quero, Anahí Sánchez Monciváis, Eduardo Beltrán Sarmiento, Rafael Ignacio Aguilar Reynoso, Daniela Murillo Reyes, Luis Rodrigo Del Río Ambriz, Juan Salvador García Hernández, Jocelyn Cruz, Sergio Iván Valdés Ferrer, Leonor Huerta, Nora Alma Fierro, Marisela Hernández, Mayra Pérez-Tapia, Gabriela Meneses, Gabriela Rosas, Juan Alberto Hernández-Aceves, Jaquelynne Cervantes-Torres, Ricardo A Valdez, Anai Fuentes Rodríguez, Erick Espíndola-Arriaga, Mauricio Ortiz, Evelyn Alvarez Salazar, Carlos Castellanos Barba, Hugo Besedovsky, Marta C Romano, Helgi Jung, Raúl J Bobes, Gloria Soldevila, Juan C López-Alvarenga, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto
BACKGROUND: SARS-CoV2 induces flu-like symptoms that can rapidly progress to severe acute lung injury and even death. The virus also invades the central nervous system (CNS), causing neuroinflammation and death from central failure. Intravenous (IV) or oral dexamethasone (DXM) reduced 28 d mortality in patients who required supplemental oxygen compared to those who received conventional care alone. Through these routes, DMX fails to reach therapeutic levels in the CNS. In contrast, the intranasal (IN) route produces therapeutic levels of DXM in the CNS, even at low doses, with similar systemic bioavailability...
January 29, 2024: Archives of Medical Research
Luis E Simental-Mendía, Mario Simental-Mendía, Amirhossein Sahebkar, Stephen L Atkin, Tannaz Jamialahmadi
BACKGROUND: Fibrates are widely used in the treatment of dyslipidemia and associated metabolic abnormalities; however, their effects on adipokines are unclear. AIM OF THE STUDY: This meta-analysis of clinical trials aimed to evaluate the effect of fibrates on circulating adipokine levels. METHODS: Only randomized controlled trials investigating the impact/effect of fibrate treatment on circulating adipokine levels were included from searches in PubMed-Medline, SCOPUS, ClinicalTrials...
January 23, 2024: Archives of Medical Research
Luis Gerardo Balcazar-Ochoa, Rosa Ventura-Martínez, Guadalupe Esther Ángeles-López, Claudia Gómez-Acevedo, Omar Francisco Carrasco, Raúl Sampieri-Cabrera, Anahí Chavarría, Abimael González-Hernández
Clavulanic acid (CLAV) is a non-antibiotic β-lactam that has been used since the late 1970s as a β-lactamase inhibitor in combination with amoxicillin, another ß-lactam with antibiotic activity. Its long-observed adverse reaction profile allows it to say that CLAV is a well-tolerated drug with mainly mild adverse reactions. Interestingly, in 2005, it was discovered that β-lactams enhance the astrocytic expression of GLT-1, a glutamate transporter essential for maintaining synaptic glutamate homeostasis involved in several pathologies of the central nervous system (CNS)...
January 2024: Archives of Medical Research
Israel Grijalva-Otero, Ernesto Doncel-Pérez
Traumatic spinal cord injury (SCI) results in partial or complete motor deficits, such as paraplegia, tetraplegia, and sphincter control, as well as sensory disturbances and autonomic dysregulation such as arterial hypotension, lack of sweating, and alterations in skin lability. All this has a strong psychological impact on the affected person and his/her family, as well as costs to healthcare institutions with an economic burden in the short, medium, and long terms. Despite at least forty years of experimental animal studies and several clinical trials with different therapeutic strategies, effective therapy is not universally accepted...
December 28, 2023: Archives of Medical Research
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