Jorge Valencia-Ortega, Rebeca González-Reynoso, Mauricio Salcedo-Vargas, Mary Flor Díaz-Velázquez, Edgar Ramos-Martínez, Aldo Ferreira-Hermosillo, Moisés Mercado, Renata Saucedo
BACKGROUND: Gestational diabetes mellitus (GDM) is the most frequent metabolic alteration in pregnancy. Several abnormalities in visceral adipose tissue (VAT) have been described as part of its pathophysiology including hypertrophy, inflammation and altered lipid metabolism. Farnesoid X receptor (FXR) is involved in adipocyte physiology and inflammation, so its expression may correlate with the expression of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), lipoprotein lipase (LPL), and two fatty acid transporters (SLC27A2, and SLC27A4)...
February 16, 2023: Archives of Medical Research
Mesut Ortatatli, Tugba Fatsa, Deniz Dogan Mulazimoglu, Sema Oren, Cumhur Artuk, Tugrul Hosbul, Neslihan Kulahlioglu, Levent Kenar
BACKGROUND: COVID-19, the 21st century pandemic disease caused by SARS-CoV-2, has shown a wide clinical spectrum ranging from asymptomatic to deadly serious pneumonia. OBJECTIVE: In our study, the relationship between the pathogenesis and clinical severity of COVID-19 and vitamin D, ACE2, Furin and TMPRSS2 was investigated. METHODS: Serum 25(OH)D, 1,25(OH)2 D and ACE2 protein were measured in 85 COVID-19 cases, divided into 5 groups, according to disease severity, from asymptomatic to severe and including a healthy control group...
February 14, 2023: Archives of Medical Research
Marisol Gouveia, Manuel Teixeira, Cristine Schmidt, Mário Lopes, Dário Trindade, Sandra Magalhães, Ana Gabriela Henriques, Alexandra Nunes, Mário Santos, Sandra Vieira, Fernando Ribeiro
BACKGROUND: Proteostasis impairment and the consequent increase of amyloid burden in the myocardium have been associated with heart failure (HF) development and poor prognosis. A better knowledge of the protein aggregation process in biofluids could assist the development and monitoring of tailored interventions. AIM: To compare the proteostasis status and protein's secondary structures in plasma samples of patients with HF with preserved ejection fraction (HFpEF), patients with HF with reduced ejection fraction (HFrEF), and age-matched individuals...
February 13, 2023: Archives of Medical Research
Heriberto Santander-Lucio, Armando Totomoch-Serra, María de Lourdes Muñoz, Normand García-Hernández, Gerardo Pérez-Ramírez, Adán Valladares-Salgado, Ashael Alfredo Pérez-Muñoz
BACKGROUND: According to the International Diabetes Federation, Mexico is seventh place in the prevalence of type 2 diabetes (T2D) worldwide. Mitochondrial DNA variant association studies in multifactorial diseases like T2D are scarce in Mexican populations. AIM OF THE STUDY: The objective of this study was to analyze the association between 18 variants in the mtDNA control region and T2D and related metabolic traits in a Mexican mestizo population from Mexico City...
February 13, 2023: Archives of Medical Research
Dawei Deng, Yuhan Zhang, Rongzhi Zhang, Jing Yi, Jianli Dong, Liyan Sha, Meiqin Yan
BACKGROUND: Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC development. METHODS: A literature search was conducted until November 2021 on Medline, Embase, Cochrane library, and Web of Science databases. Studies were included if they assessed circulating proteins and metabolites in blood, urine, or saliva and determined their association with GC risk...
February 7, 2023: Archives of Medical Research
Na-Kyung Lee, Jae-Won Lee, Jeong-Hwa Woo, Youn Seok Choi, Jung-Hye Choi
BACKGROUD AND AIM: Endometriosis is one of the most common gynecological diseases associated with chronic pelvic pain, infertility, and cancer. However, its molecular pathogenesis remains unclear. This study aimed to identify key genes involved in the pathogenesis of endometriosis. METHODS: Bioinformatic analyses were perfomed to identify key differentially expressed genes (DEGs), transcription factors (TFs), and functionally enriched pathways. Effect of SPI1 on migration, invasion, expression of ADH1B, MYH11, and PLN were analyzed in human endometriotic cells...
February 2023: Archives of Medical Research
Shanhu Qiu, Qianqian Wang, Wenji Chen, Bo Xie, Duolao Wang, Xue Cai, Zilin Sun, Tongzhi Wu
BACKGROUND: The existing literature regarding the association between muscle strength and cardiovascular disease (CVD) and all-cause mortality relies mostly on a single measurement of muscle strength but has seldomly focused on the accumulated exposure. OBJECTIVE: This study explored the association between cumulative muscle strength and risks of CVD and all-cause mortality in middle-aged and older adults. METHODS: A total of 6,972 patients from the China Health and Retirement Longitudinal Study, who underwent 3 repeated measurements of muscle strength over 4 years and were followed-up for another 3 years for CVD and all-cause mortality outcomes participated in this study...
January 31, 2023: Archives of Medical Research
Manuel G Ballesteros-Monrreal, Pablo Mendez-Pfeiffer, Edwin Barrios-Villa, Margarita M P Arenas-Hernández, Yessica Enciso-Martínez, César O Sepúlveda-Moreno, Enrique Bolado-Martínez, Dora Valencia
BACKGROUND: Urinary tract infections (UTI) are one of the most common pathologies in Mexico and the majority are caused by uropathogenic Escherichia coli (UPEC). UPEC possesses virulence and resistance determinants that promote UTI development and affect diagnosis and treatment. This study aims to systematically review published reports of virulence genes, antibiotic resistance, and phylogenetic groups prevalent in clinical isolates of UPEC in the Mexican population. METHODS: Systematic review with meta-analysis was performed following PRISMA guidelines...
January 30, 2023: Archives of Medical Research
Yasaman Kargar-Sichani, Mohammad Hossein Mohammadi, Vahid Amiri, Mohyedin Barzegar, Ali Keshavarz, Davood Bashash, Mehdi Allahbakhshian Farsani
OBJECTIVE: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder resulting from a complex interplay between leukemic cells and supporting factors from their microenvironment. In this context, extracellular vesicles (EVs) have been shown to play an essential role in forming a tumor-protective microenvironment. In this study, we examined the influence of AML-derived EVs on cellular and molecular characterization of bone marrow mesenchymal stromal cells (BM-MSCs), particularly alteration in the expression of genes (IL-6, Gas-6, and Galectin-3) relating to relapse and chemoresistance...
January 28, 2023: Archives of Medical Research
Simin Zafardoust, Somaieh Kazemnejad, Maryam Darzi, Mina Fathi-Kazerooni, Zahra Saffarian, Niloofar Khalili, Haleh Edalatkhah, Ebrahim Mirzadegan, Somayeh Khorasani
BACKGROUND: Premature ovarian failure (POF) is a well-known cause of infertility, particularly in women under the age of 40. POF is also associated with elevated gonadotropin levels, amenorrhea and sex-hormone deficiency. AIM OF THE STUDY: In this study, the therapeutic potential of autologous mesenchymal stromal cells obtained from menstrual blood (Men-MSCs) for patients with POF was evaluated. METHODS: 15 POF patients were included in the study...
January 24, 2023: Archives of Medical Research
Alejandra Montoya, Rafael Lozano, Mario Sanchez-Dominguez, Jimena Fritz, Héctor Lamadrid-Figueroa
BACKGROUND: Estimates of the sub-national distribution of maternal disorders in Mexico beyond Maternal Mortality Ratios are scarce. Characterizing the sub-national variation of maternal disorders may make it possible to focus more on interventions and thereby reduce their occurrence in a more meaningful and sustained manner. AIM: To analyze and describe the sub-national distribution, magnitude, trends and changes in the contribution of maternal causes to women's loss of health in Mexico from 1990-2019...
January 24, 2023: Archives of Medical Research
Xiqiang Wang, Xiude Fan, Yanpeng Ma, Ling Zhu, Ting Wang, Jing Liu, Chengfeng Liu, Tomohiro Hayashi, Gongchang Guan, Shuo Pan, Zhongwei Liu, Junkui Wang
AIMS: Mitral regurgitation (MR) is the most prevalent form of valvular heart disease. Transcatheter mitral valve repair (TMVr) and transcatheter mitral valve replacement (TMVR) have recently emerged as alternatives to open heart surgical repair or replacement. However, studies on the comparative outcomes of TMVr and TMVR are limited. This study aims to compare the demographics, complications and outcomes of TMVr and TMVR based on a real-world investigation of the National Inpatient Sample (NIS) database...
January 13, 2023: Archives of Medical Research
Ísis Salviano Soares de Amorim, Isabelle Xavier Dias, Daphne Pinheiro, Simone Nunes de Carvalho, Pedro Nicolau-Neto, Juliana Alves Rodrigues, Priscyanne Barreto Siqueira, Matheus da Silva Oliveira, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
BACKGROUND: In breast cancer (BC), hypoxia is associated with poor prognosis. Protein Salvador homolog 1 (SAV1) acts as a tumor suppressor and is downregulated in the cancer cells. However, there is limited data on the expression profile of SAV1 and its importance in BC. It has not been studied to evaluate this phenomenon in a hypoxic microenvironment yet. AIM: This study aimed to investigate SAV1 expression profiles under normoxia and hypoxia, and the potential of SAV1 in BC prognosis...
January 4, 2023: Archives of Medical Research
Mateo Porres-Aguilar, Jack Ansell, Debabrata Mukherjee, Xóchitl Cota-Rangel, Ricardo Martínez-Zubieta, Raúl Carrillo-Esper, Allison E Burnett
Antithrombotic therapies, especially anticoagulants, are high-risk medications with increased potential for adverse events. The development and implementation of a well-functioning, designated, multidisciplinary anticoagulation stewardship program (MASP), tailored to each hospital-center's needs, has the primary objectives of improving patient-centered outcomes, minimizing undesirable anticoagulation-related adverse events and minimizing hospital length of stay (LOS) and other patient-related costs. Such stewardship programs are pivotal in supporting busy clinicians with consultation on challenging clinical case scenarios, ensuring appropriate use of valuable healthcare resources, achieving compliance with anticoagulant-associated accreditation standards, and positively impacting patient-specific morbidity/mortality outcomes...
January 2023: Archives of Medical Research
Liangyan Jiang, Xiaorong Li, Juntao Hu, Zhanhong Tang
BACKGROUND: Multiple organ failure secondary to severe sepsis leads to increased morbidity and mortality and is often accompanied by inflammation and immune system dysfunction. Mild hypothermia has been shown to have anti-inflammatory properties, but whether it can exert a protective effect in cases of multiple organ failure remains unclear. Thus, in this study, we investigated the protective effect of mild hypothermia on septic multiple organ failure and the underlying mechanism for this effect...
December 30, 2022: Archives of Medical Research
Gabriel Gárate, Marta Pascual, Montserrat Rivero, María Toriello, Sara Pérez-Pereda, Vicente González-Quintanilla, Jorge Madera, Manuel Gutiérrez-Cuadra, María Del Carmen Fariñas, José Luis Hernández, José Manuel Olmos, Julio Pascual
BACKGROUND: Vasoactive peptides play an important role in a wide range of physiological and pathological conditions. Due to its known functions, the calcitonin gene-related peptide (CGRP) has been suggested as a possible modulator of the hyperimmune response in COVID-19 and thus, blocking its action may lessen the pulmonary effects of COVID-19. AIM OF THE STUDY: To compare the circulating levels of CGRPα and CGRPβ in healthy controls compared to hospitalized COVID-19 patients...
December 30, 2022: Archives of Medical Research
Rezvan Tavakoli, Pooneh Rahimi, Mojtaba Hamidi-Fard, Sana Eybpoosh, Delaram Doroud, Seyed Amir Sadeghi, Mohammadali Zaheri Birgani, Mohammadreza Aghasadeghi, Abolfazl Fateh
OBJECTIVE: The innate immune response in humans involves a wide variety of factors, including the tripartite motif-containing 5α (TRIM5α) and 22 (TRIM22) as a cluster of genes on chromosome 11 that have exhibited antiviral activity in several viral infections. We analyzed the correlation of the expression of TRIM5α and TRIM22 with the severity of Coronavirus Disease 2019 (COVID-19) in blood samples of 330 patients, divided into two groups of severe and mild disease, versus the healthy individuals who never had contact with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)...
December 28, 2022: Archives of Medical Research
Juan José Oropeza-Valdez, José de la Cruz Moreira Hernandez, Elena Jaime-Sánchez, Ernesto López-Ramos, Edgar E Lara-Ramírez, Yamilé López Hernández, Julio Enrique Castañeda-Delgado, José Antonio Enciso Moreno
BACKGROUND: The early diagnosis of diabetic nephropathy (DN) is essential for improving the prognosis and effectively manage patients affected with this disease. The standard biomarkers, including albuminuria and glomerular filtration rate, are not very precise. New molecular biomarkers are needed to more accurately identify DN and better predict disease progression. Characteristic DN biomarkers can be identified using transcriptomic analysis. AIM OF THE STUDY: To evaluate the transcriptomic profile of controls (CTRLs, n = 15), patients with prediabetes (PREDM, n = 15), patients with type-2 diabetes mellitus (DM2, n = 15), and patients with DN (n = 15) by microarray analysis to find new biomarkers...
December 22, 2022: Archives of Medical Research
Xiaoyue Yang, Rui Hu, Yajun Zhu, Zhen Wang, Yilin Hou, Kangkang Su, Xiaoyu He, Guangyao Song
BACKGROUND: Previous studies have shown an association between low serum vitamin B12 levels and the risk of diabetic retinopathy (DR) in type 2 diabetes, but the conclusions from various studies were inconsistent. Therefore, we collected relevant data from various databases to perform a meta-analysis and address the inconsistencies in these studies. METHODS: We searched PubMed, Embase, Cochrane Library, CNKI, Wanfang and CQVIP for eligible studies published up to April 10, 2022, and performed a meta-analysis using Stata software to assess the association between serum vitamin B12 levels and DR...
December 20, 2022: Archives of Medical Research
Hyat Ahmed Ibrahim Al-Raimi, Jing Kong, Yan Ran, Lei Zhu, Jiao Li, Xue Liu, Xuesong Yang, Dongyuan Qi, Tingjiao Liu
BACKGROUND: Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer progression. Salivary adenoid cystic carcinoma (SACC) has a high tendency to invade and metastasize. Understanding how CAFs interact with SACC cells is essential for developing new targeted therapies for SACC. Extracellular vesicles (EVs) play important roles in intercellular communication. However, the role of CAFs-derived EVs in SACC invasion remains poorly understood. AIM OF THE STUDY: To show that CAFs EVs are involved in the EMT of SACC and promote tumor invasion...
December 19, 2022: Archives of Medical Research
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