journal
https://read.qxmd.com/read/38157747/traumatic-human-spinal-cord-injury-are-single-treatments-enough-to-solve-the-problem
#21
REVIEW
Israel Grijalva-Otero, Ernesto Doncel-Pérez
Traumatic spinal cord injury (SCI) results in partial or complete motor deficits, such as paraplegia, tetraplegia, and sphincter control, as well as sensory disturbances and autonomic dysregulation such as arterial hypotension, lack of sweating, and alterations in skin lability. All this has a strong psychological impact on the affected person and his/her family, as well as costs to healthcare institutions with an economic burden in the short, medium, and long terms. Despite at least forty years of experimental animal studies and several clinical trials with different therapeutic strategies, effective therapy is not universally accepted...
December 28, 2023: Archives of Medical Research
https://read.qxmd.com/read/38154234/expression-of-epb41l2-in-cancer-associated-fibroblasts-prognostic-implications-for-bladder-cancer-and-response-to-immunotherapy
#22
JOURNAL ARTICLE
Tianqi Wang, Guixin Ding, Xiaoyu Wang, Yuanshan Cui, Xiaohong Ma, Jian Ma, Jitao Wu
BACKGROUND: Immunotherapy response in patients with bladder cancer (BLCA) treated with immune checkpoint inhibitors (ICIs) is variable. The accurate evaluation of immunotherapy efficacy may be facilitated by the tumor microenvironment (TME). Erythrocyte membrane protein band 4.1 like 2 (EPB41L2), a cytoskeletal protein with a regulatory role in the TME was intensively investigated to determine its biological characterization, clinical relevance, and predictive value for immunotherapy in BLCA...
December 27, 2023: Archives of Medical Research
https://read.qxmd.com/read/38141272/spanish-adaptation-and-validation-of-the-als-depression-inventory-12-adi-12-in-patients-with-amyotrophic-lateral-sclerosis
#23
JOURNAL ARTICLE
David Sancho-Cantus, Laura Cubero-Plazas, Jesús Privado, Eduardo Jesús Aguilar García-Iturrospe, Montserrat Cañabate Ros, Esther Navarro-Illana, José Enrique de la Rubia Ortí
BACKGROUND: Patients with Amyotrophic Lateral Sclerosis (ALS) have a higher prevalence of mood disorders, including depression, than the general population. Non-specific measurement instruments have been used to evaluate depression in these patients, which complicates accurate diagnosis. The ALS Depression Inventory (ADI-12) exclusively assesses depressive symptoms in patients with ALS. AIM: To adapt and validate the ADI-12 in a Spanish sample. METHODS: A selective design was used with 74 patients with ALS, using the ADI-12 questionnaire...
December 22, 2023: Archives of Medical Research
https://read.qxmd.com/read/38141271/multidisciplinary-panel-consensus-for-the-management-of-patients-with-type-2-diabetes-a-delphi-study
#24
JOURNAL ARTICLE
Ana M Cebrián-Cuenca, Oscar Moreno-Pérez, Raquel Campuzano-Ruiz, Maria Jose Soler, M Dolores García de Lucas, Domingo Orozco-Beltrán
AIM: To reach a multidisciplinary consensus on managing patients with type 2 diabetes among specialists in family medicine, cardiology, endocrinology, internal medicine, and nephrology. METHODS: A two-round Delphi study was conducted using a questionnaire with 68 positive/negative statements distributed in four thematic blocks on diabetes management: early diagnosis and prediabetes, referral criteria, treatment and comorbidities, and clinical management. The expert panel was composed of 105 physicians from different specialties (family medicine, cardiology, endocrinology, internal medicine, and nephrology) with experience in managing patients with diabetes and who were members of a diabetes-related society...
December 22, 2023: Archives of Medical Research
https://read.qxmd.com/read/38065013/factor-xii-deficiency-in-mexico-high-prevalence-in-the-general-population-and-patients-with-venous-thromboembolic-disease
#25
JOURNAL ARTICLE
Víctor Manuel Dominguez-Reyes, Jesus Hernandez-Juarez, Rodrigo Arreola-Diaz, Karim Majluf-Cruz, Elba Reyes-Maldonado, José Antonio Alvarado-Moreno, Luis Antonio Moreno Ruiz, Abraham Majluf-Cruz
INTRODUCTION: Thrombosis is one of the leading causes of morbidity and mortality worldwide. Venous thromboembolic disease (VTD) is considered a new epidemic. FXII deficiency is supposed to be a cause of thrombosis. To search for unknown causes of thrombosis in our population, our aim was to determine if FXII deficiency can be considered a risk factor for VTD. METHODS: Young adult Mexican patients with at least one VTD episode and healthy controls were included in this prospective, observational, controlled study...
December 7, 2023: Archives of Medical Research
https://read.qxmd.com/read/38061162/multimodal-prognostic-model-for-predicting-chronic-coronary-artery-disease-in-patients-without-obstructive-sleep-apnea-syndrome
#26
JOURNAL ARTICLE
Yanan Xu, Jun Wang, Zhen Zhou, Yi Yang, Long Tang
BACKGROUND: Obstructive sleep apnea syndrome (OSAS), with metabolic disorders as a central feature, is closely correlated with coronary artery disease (CAD). Our goal was to develop a prediction nomogram that integrated multimodal data that could accurately predict the prognosis of patients with chronic coronary disease (CCD). METHODS: We evaluated 393 patients with CCD with a low-to-intermediate pretest probability of OSAS based on polysomnography. A nomogram was constructed by means of least absolute shrinkage and selection operator (LASSO) and multiple Cox regression analyses to identify independent risk factors for major adverse cardiovascular events (MACEs)...
December 6, 2023: Archives of Medical Research
https://read.qxmd.com/read/38042683/predictors-of-response-to-treatment-with-first-generation-somatostatin-receptor-ligands-in-patients-with-acromegaly
#27
JOURNAL ARTICLE
Montserrat Marques-Pamies, Joan Gil, Mireia Jordà, Manel Puig-Domingo
BACKGROUND AND AIMS: Predictors of first-generation somatostatin receptor ligands (fgSRLs) response in acromegaly have been studied for over 30 years, but they are still not recommended in clinical guidelines. Is there not enough evidence to support their use? This systematic review aims to describe the current knowledge of the main predictors of fgSRLs response and discuss their current usefulness, as well as future research directions. METHODS: A systematic search was performed in the Scopus and PubMed databases for functional, imaging, and molecular predictive factors...
December 1, 2023: Archives of Medical Research
https://read.qxmd.com/read/38042031/abhd5-cpt1b-an-important-way-of-regulating-placental-lipid-metabolism-in-gestational-diabetes-mellitus
#28
JOURNAL ARTICLE
Yuqi Yang, Yue Peng, Bin Yu, Huiyan Wang
BACKGROUND AND AIM: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders in pregnancy, and a novel association of maternal lipid profile has been suggested to play an important role. However, the molecular mechanism is not clear. METHODS: Bio-analyzed combined with placental metabonomics and single-cell RNA-sequencing (scRNA-seq) successfully identified a potentially important molecule: α-β hydrolase domain-containing protein 5 (ABHD5)...
December 1, 2023: Archives of Medical Research
https://read.qxmd.com/read/38007384/ectopic-hormonal-syndromes-cushing-s-syndrome-and-acromegaly
#29
REVIEW
Claudia Ramirez-Renteria
Ectopic hormone production may be present in neuroendocrine and non-endocrine neoplasms. Ectopic sources of growth hormone, adrenocorticotropin (ACTH), or their releasing factors are uncommon but clinically relevant. Ectopic ACTH tumors have been studied more than the rest, but there are still no comprehensive multidisciplinary guidelines that include all the pitfalls in the diagnosis and management of ectopic hormonal syndromes and the neoplasms associated with ectopic Cushing or acromegaly. The frequency of neuroendocrine neoplasms and other neoplasms with neuroendocrine differentiation has been increasing in recent decades...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37985276/impulse-control-disorders-in-patients-with-pituitary-tumors-treated-with-dopamine-agonists-a-systematic-review
#30
JOURNAL ARTICLE
Ross Hamblin, Niki Karavitaki
BACKGROUND: The increased prevalence of Impulse Control Disorders (ICDs) in dopamine agonist (DA) treated patients with Parkinson's disease is well described. Despite the frequent use of DAs in the management of pituitary tumors, the relationship between DAs and prevalence of ICDs in patients with pituitary tumours is unclear. AIMS: To establish the prevalence of ICDs in patients with prolactinoma or acromegaly and determine whether prevalence differs in those on DAs to those treated without...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37981525/genomics-transcriptomics-and-epigenetics-of-sporadic-pituitary-tumors
#31
REVIEW
Daniel Marrero-Rodríguez, Sandra Vela-Patiño, Florencia Martinez-Mendoza, Alejandra Valenzuela-Perez, Eduardo Peña-Martínez, Amayrani Cano-Zaragoza, Jacobo Kerbel, Sergio Andonegui-Elguera, Shimon S Glick-Betech, Karla X Hermoso-Mier, Sophia Mercado-Medrez, Alberto Moscona-Nissan, Keiko Taniguchi-Ponciano, Moises Mercado
Pituitary tumors (PT) are highly heterogeneous neoplasms, comprising functioning and nonfunctioning lesions. Functioning PT include prolactinomas, causing amenorrhea-galactorrhea in women and sexual dysfunction in men; GH-secreting adenomas causing acromegaly-gigantism; ACTH-secreting corticotrophinomas causing Cushing disease (CD); and the rare TSH-secreting thyrotrophinomas that result in central hyperthyroidism. Nonfunctioning PT do not result in a hormonal hypersecretion syndrome and most of them are of gonadotrope differentiation; other non-functioning PT include null cell adenomas and silent ACTH-, GH- and PRL-adenomas...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37977919/pharmacological-treatment-of-cushing-s-syndrome
#32
REVIEW
Frederic Castinetti
The 1st line treatment of Cushing's syndrome is surgery, whatever the aetiology. The role of pharmacological treatment is clear in cases where surgery fails or is impossible, in cases of metastases, or while awaiting the delayed effects of radiotherapy. However, certain situations remain controversial, in particular the possible role of pharmacological treatment as a preparation for surgery. This situation must be divided into 2 parts, severe hypercortisolism with immediate vital risk and non-severe hypercortisolism with diagnostic delay...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37945442/obesity-as-a-neuroendocrine-disorder
#33
REVIEW
Aldo Ferreira-Hermosillo, Regina de Miguel Ibañez, Enid Karina Pérez-Dionisio, Karen Alexandra Villalobos-Mata
Obesity is one of the most prevalent diseases in the world. Based on hundreds of clinical and basic investigations, its etiopathogenesis goes beyond the simple imbalance between energy intake and expenditure. The center of the regulation of appetite and satiety lies in the nuclei of the hypothalamus where peripheral signals derived from adipose tissue (e.g., leptin), the gastrointestinal tract, the pancreas, and other brain structures, arrive. These signals are part of the homeostatic control system (eating to survive)...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37925320/clinical-spectrum-of-usp8-pathogenic-variants-in-cushing-s-disease
#34
REVIEW
Rosa G Rebollar-Vega, Julia M Zuarth-Vázquez, Laura C Hernández-Ramírez
Cushing's disease (CD) is a life-threatening condition with a challenging diagnostic process and scarce treatment options. CD is caused by usually benign adrenocorticotrophic hormone (ACTH)-secreting pituitary neuroendocrine tumors (PitNETs), known as corticotropinomas. These tumors are predominantly of sporadic origin, and usually derive from the monoclonal expansion of a mutated cell. Somatic activating variants located within a hotspot of the USP8 gene are present in 11-62% of corticotropinomas, making USP8 the most frequent genetic driver of corticotroph neoplasia...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37806785/long-term-discontinuation-of-dopamine-agonist-treatment-in-patients-with-prolactinomas-revisited
#35
REVIEW
Ernesto Sosa-Eroza, Etual Espinosa-Cárdenas
The most common type of functioning pituitary adenomas is prolactinomas; unlike other types, they are treated medically with dopamine agonists (DA). This treatment aims to normalize PRL levels and decrease tumor size by 50% or more. These objectives are typically achieved by 90% of patients with microprolactinoma, two-thirds of those with macroprolactinomas, and about half of those with giant prolactinomas. Life-long pharmacological treatment implies costs, discomfort, and the possibility of side effects, therefore, it has been suggested that DA discontinuation could be attempted in some patients...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37749028/non-invasive-biochemical-testing-of-acth-dependent-cushing-s-disease-do-we-still-need-petrosal-sinus-sampling
#36
REVIEW
Etual Espinosa-Cardenas, Manuel Garcia-Saenz, Ana Laura Espinosa de Los Monteros-Sanchez, Ernesto Sosa-Eroza
Differentiating between a pituitary from an ectopic source of ACTH could be a real one of the major challenges of clinical endocrinology. The Bilateral inferior petrosal sinus sampling (BIPSS) is considered the gold standard for identifying the source of ACTH; however, is not available worldwide. After the SARS-CoV-2 pandemic, algorithms that include biochemical and imaging tests have gained importance as an alternative to BIPSS. This review summarizes the drawbacks in the differential diagnosis of ACTH-dependent Cushing; the evolution of diagnostic tests, and the evidence that exists on their performance...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/37689507/prolactinomas-resistant-to-dopamine-agonists-pathophysiology-and-treatment
#37
REVIEW
Ilan Shimon
Prolactinomas are the most common functional pituitary tumors, accounting for 40% of all pituitary adenomas. Medical treatment with dopamine agonists (DA), mainly cabergoline, is considered the primary therapy for these patients. Prolactin normalization is achieved in 80-90% of prolactinomas treated with cabergoline. Patients resistant to the standard dose can escalate the dose of cabergoline up to the maximum tolerated dose. The expression of dopamine (D2) receptors and dopamine affinity is decreased in aggressive and resistant prolactinomas...
December 2023: Archives of Medical Research
https://read.qxmd.com/read/38040528/controversies-in-neuroendocrinology
#38
EDITORIAL
Philippe Chanson, Moises Mercado
No abstract text is available yet for this article.
November 30, 2023: Archives of Medical Research
https://read.qxmd.com/read/38040527/efficacy-and-safety-of-endoscopic-transsphenoidal-resection-for-prolactinoma-a-retrospective-multicenter-case-series
#39
JOURNAL ARTICLE
Ingrid Marijke Zandbergen, Kristin Michelle Huntoon, Timothy G White, Leontine Erica Henriëtte Bakker, Marco Johanna Theodorus Verstegen, Luma Mudhafar Ghalib, Wouter Ralph van Furth, Iris Catharina Maria Pelsma, Amir R Dehdashti, Nienke Ruurdje Biermasz, Daniel M Prevedello
BACKGROUND: Endoscopic transsphenoidal surgery (ETSS) for prolactinoma is reserved for dopamine agonist (DA) resistance, intolerance, or apoplexy. High remission (overall 67%, microprolactinoma up to 90%), low recurrence (5-20%) rates highlighted that surgery might be first-line treatment. AIMS: To report on outcomes of ETSS in a cohort of prolactinomas. METHODS: Multicenter retrospective cohort of 137 prolactinoma patients (age 38.2 ± 13...
November 30, 2023: Archives of Medical Research
https://read.qxmd.com/read/38040526/acromegalic-cardiomyopathy-an-entity-on-its-own-the-effects-of-gh-and-igf-i-excess-and-treatment-on-cardiovascular-risk-factors
#40
REVIEW
Peter Wolf, Luigi Maione, Peter Kamenický, Philippe Chanson
Acromegaly is a chronic disease resulting from constantly elevated concentrations of growth hormone (GH) and insulin-like growth factor I (IGF-I). If not adequately treated, GH and IGF-I excess is associated with various cardiovascular risk factors. These symptoms mainly include hypertension and impaired glucose metabolism, which can be observed in approximately one-third of patients. Other comorbidities are dyslipidemia and the presence of obstructive sleep apnea syndrome. However, even in the absence of conventional cardiovascular risk factors, myocardial hypertrophy can occur, which reflects the impact of GH and IGF-I excess itself on the myocardium and is defined as acromegalic cardiomyopathy...
November 30, 2023: Archives of Medical Research
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