Ming Chen, Wei Wei, Yi Li, Siliang Ge, Junmin Shen, Jiayu Guo, Yu Zhang, Xiang Huang, Xinyu Sun, Dongliang Cheng, Huayong Zheng, Feifan Chang, Junyu Chen, Jiang Liu, Qinxiang Zhang, Tianjunke Zhou, Kang Yu, Peifu Tang
Irritable bowel syndrome (IBS) is a widespread gastrointestinal disorder known for its multifaceted pathogenesis and varied extraintestinal manifestations, yet its implications for bone and muscle health are underexplored. Recent studies suggest a link between IBS and musculoskeletal disorders, but a comprehensive understanding remains elusive, especially concerning the role of bile acids (BAs) in this context. This study aimed to elucidate the potential contribution of IBS to bone and muscle deterioration via alterations in gut microbiota and BA profiles, hypothesizing that cholestyramine could counteract these adverse effects...
March 25, 2024: Cell Proliferation