Ashley M Geczik, Kara A Michels, Garnet L Anderson, Roni T Falk, Leslie V Farland, JoAnn E Manson, Aladdin H Shadyab, Ruth M Pfeiffer, Xia Xu, Britton Trabert
PURPOSE: Hysterectomy is associated with subsequent changes in circulating hormone levels, but the evidence of an association for tubal ligation is unclear. We evaluated whether circulating concentrations of androgens and estrogens differ by tubal ligation or hysterectomy status in postmenopausal women from the Women's Health Initiative (WHI)-Observational Study (OS). METHODS: Serum androgens and estrogens were measured in 920 postmenopausal women who did not use menopausal hormone therapy at the time of blood draw, of whom 139 self-reported a history of tubal ligation and 102 reported hysterectomy (with intact ovaries)...
May 21, 2024: Cancer Causes & Control: CCC
Yuxiao Zhang, Min Zhang, Shanjiamei Jiang, Heng Hu, Xinzhi Wang, Fan Yu, Yue'e Huang, Yali Liang
OBJECTIVES: This study investigated the potential effects of perfluoroalkyl substance (PFAS) in serum on MAFLD, NAFLD, and liver fibrosis. METHODS: Our sample included 696 participants (≥ 18 years) from the 2017-2018 NHANES study with available serum PFASs, covariates, and outcomes. Using the first quartile of PFAS as the reference group, we used weighted binary logistic regression and multiple ordered logistic regression used to analyze the relationship between PFAS and MAFLD, NAFLD, and liver fibrosis and multiple ordinal logistic regression to investigate the relationship between PFAS and MAFLD, NAFLD, and liver fibrosis and calculated the odds ratio (OR) and 95% confidence interval for each chemical...
May 19, 2024: Cancer Causes & Control: CCC
Edgar T Ellis, Brian J Fairman, Shelbie D Stahr, Jeannette T Bensen, James L Mohler, Lixin Song, Eboneé N Butler, L Joseph Su, Ping-Ching Hsu
PURPOSE: Smoking is a modifiable lifestyle factor that has not been established as a prostate cancer risk factor, nor emphasized in prostate cancer prevention. Studies have shown that African American (AA) smokers have a poorer cancer prognosis than European Americans (EAs), while having a lower prevalence of heavy smoking. We examined the relationship between cigarette smoking and prostate cancer aggressiveness and assessed racial differences in smoking habits on the probability of high-aggressive prostate cancer...
May 17, 2024: Cancer Causes & Control: CCC
Rachel Walsh, Aisha Lofters, Patti Groome, Rahim Moineddin, Monika Krzyzanowska, Rebecca Griffiths, Eva Grunfeld
PURPOSE: The time from breast cancer surgery to chemotherapy has been shown to affect survival outcomes; however, the effect of time from first breast cancer-related healthcare contact to first cancer specialist consultation, or the time from first breast cancer-related healthcare contact to adjuvant chemotherapy on survival has not been well explored. We aimed to determine whether various wait times along the breast cancer treatment pathway (contact-to-consultation, contact-to-chemotherapy, surgery-to-chemotherapy) were associated with overall survival in women within the Canadian province of Ontario...
May 15, 2024: Cancer Causes & Control: CCC
Michelle D Holmes
The lack of Black doctors may contribute to the racial disparity in breast cancer survival.
May 15, 2024: Cancer Causes & Control: CCC
Paul Gerardo Yeh, Audrey C Choh, Susan P Fisher-Hoch, Joseph B McCormick, David R Lairson, Belinda M Reininger
PURPOSE: The relationship between engaging in two domains of cancer-preventive behaviors, lifestyle behaviors and colonoscopy screening, is unknown in Hispanic adults. Accordingly, the study examined the association between lifestyle and colonoscopy screening in Hispanic adults along the Texas-Mexico border, where there is suboptimal colorectal cancer prevention. METHODS: Lifestyle behavior adherence and compliance with colonoscopy screening schedules were assessed using 2013-2023 data from the Cameron County Hispanic Cohorta population-based sample of Hispanic adults living along the Texas-Mexico border...
May 14, 2024: Cancer Causes & Control: CCC
Nicholas Yell, Jan M Eberth, Anthony J Alberg, Peiyin Hung, Mario Schootman, Alexander C McLain, Reginald F Munden
PURPOSE: In 2021, the United States Preventive Services Task Force (USPSTF) revised their 2013 recommendations for lung cancer screening eligibility by lowering the pack-year history from 30+ to 20+ pack-years and the recommended age from 55 to 50 years. Simulation studies suggest that Black persons and females will benefit most from these changes, but it is unclear how the revised USPSTF recommendations will impact geographic, health-related, and other sociodemographic characteristics of those eligible...
May 8, 2024: Cancer Causes & Control: CCC
Hind A Beydoun, Jack Tsai
PURPOSE: The Veterans Health Administration (VHA) is the largest integrated healthcare system in the U.S. While preventive healthcare services are high priority in the VHA, low-income U.S. Veterans experience adverse life circumstances that may negatively impact their access to these services. This study examined lifetime prevalence as well as demographic, socioeconomic, military-specific, and clinical correlates of colorectal cancer (CRC) screening among low-income U.S. Veterans ≥ 50 years of age...
May 7, 2024: Cancer Causes & Control: CCC
Jonathan N Odumegwu, Daniel Chavez-Yenter, Melody S Goodman, Kimberly A Kaphingst
PURPOSE: Genetic testing for gene mutations which elevate risk for breast cancer is particularly important for women diagnosed at a young age. Differences remain in access and utilization to testing across social groups, and research on the predictors of interest in genetic testing for women diagnosed at a young age is limited. METHODS: We examined the relationships between subjective social status (SSS) and variables previously identified as possible predictors of genetic testing, including genome sequencing knowledge, genetic worry, cancer worry, health consciousness, decision-making preferences, genetic self-efficacy, genetic-related beliefs, and subjective numeracy, among a cohort of women who were diagnosed with breast cancer at a young age...
May 3, 2024: Cancer Causes & Control: CCC
Yumeng Ren, Joanna Maselko, Xianming Tan, Andrew F Olshan, Angela M Stover, Antonia V Bennett, Katherine E Reeder-Hayes, Jessie K Edwards, Bryce B Reeve, Melissa A Troester, Marc A Emerson
PURPOSE: Emotional and functional well-being (EWB and FWB) are important components of mental health and quality of life. This study aims to evaluate long-term EWB and FWB in breast cancer (BC) survivors. METHODS: The Carolina Breast Cancer Study Phase 3 oversampled Black and younger (< 50 years in age) women so that they each represent approximately 50% of the study population and assessed participants' EWB and FWB with the Functional Assessment of Cancer Therapy-Breast (FACT-B) at 5- (baseline), 25-, and 84-months post diagnosis...
April 20, 2024: Cancer Causes & Control: CCC
Adam C Powell, Jeremy T Pickerell, James W Long, Bryan A Loy, Amin J Mirhadi
PURPOSE: Prior data have demonstrated relationships between patient characteristics, the use of surgery to treat lung cancer, and the timeliness of treatment. Our study examines whether these relationships were observable in 2019 in patients with Medicare Advantage health plans being treated for lung cancer. METHODS: Claims data pertaining to patients with Medicare Advantage health plans who had received radiation therapy (RT) or surgery to treat lung cancer within 90 days of diagnostic imaging were extracted...
April 18, 2024: Cancer Causes & Control: CCC
Patrick Hinton, Paul J Villeneuve, Elisabeth Galarneau, Kristian Larsen, Deyong Wen, Jun Meng, Verica Savic-Jovcic, Junhua Zhang, Will D King
PURPOSE: Polycyclic aromatic hydrocarbons (PAHs) represent a class of ubiquitous pollutants recognized as established human carcinogens and endocrine-disrupting chemicals. PAHs have seldom been modeled at the population-level in epidemiological studies. Fluoranthene is a prevalent PAH in urban settings and correlates with the occurrence of other PAHs. The purpose of this study was to evaluate associations between long-term residential exposure to ambient PAHs and breast cancer risk, both pre- and post-menopausal, in Canada...
April 17, 2024: Cancer Causes & Control: CCC
Eloïse Berger, Amandine Gelot, Agnès Fournier, Laure Dossus, Marie-Christine Boutron-Ruault, Gianluca Severi, Raphaële Castagné, Cyrille Delpierre
PURPOSE: Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent conclusions. We aimed to investigate the impact of education on BC stage, grade, and hormone receptor (HR) status, while adjusting for potential confounders including a broad set of health behaviors, anthropometric measures, and reproductive factors. METHODS: In the French E3N cohort, 5236 women developed a primary invasive BC for which there was available information on stage, grade, and HR status...
April 14, 2024: Cancer Causes & Control: CCC
Jihwan Hwang, Patricia Markham Risica, Eric Lamy, William Goedel
BACKGROUND: Cancer screening is effective in reducing the burden of breast, cervical, and colorectal cancers, but not all communities have appropriate access to these services. In this study, we aimed to identify under-resourced communities by assessing the association between the Social Vulnerability Index (SVI) with screening rates for breast, cervical, and colorectal cancers in ZIP-code tabulation areas (ZCTAs) in Rhode Island. METHODS: This study leveraged deidentified health insurance claims data from HealthFacts RI, the state's all-payer claims database, to calculate screening rates for breast, cervical, and colorectal cancers using Healthcare Effectiveness Data and Information Set measures...
April 13, 2024: Cancer Causes & Control: CCC
Dan Lin, Cheryl L Thompson, Alaina Demalis, Rebecca Derbes, Laila Al-Shaar, Emma S Spielfogel, Kathleen M Sturgeon
PURPOSE: Studies have reported inverse associations of pre-diagnosis recreational physical activity (RPA) level with all-cause and breast cancer (BCa)-specific mortality among BCa patients. However, the association between pre-diagnosis RPA level and BCa recurrence is unclear. We investigated the association between pre-diagnosis RPA level and risk of BCa recurrence in the California Teachers Study (CTS). METHODS: Stage I-IIIb BCa survivors (n = 6,479) were followed with median of 7...
April 13, 2024: Cancer Causes & Control: CCC
Erica J Lee Argov, Carmen B Rodriguez, Mariangela Agovino, Karen M Schmitt, Elise Desperito, Anita G Karr, Ying Wei, Mary Beth Terry, Parisa Tehranifar
PURPOSE: Nationally legislated dense breast notification (DBN) informs women of their breast density (BD) and the impact of BD on breast cancer risk and detection, but consequences for screening participation are unclear. We evaluated the association of DBN in New York State (NYS) with subsequent screening mammography in a largely Hispanic/Latina cohort. METHODS: Women aged 40-60 were surveyed in their preferred language (33% English, 67% Spanish) during screening mammography from 2016 to 2018...
April 12, 2024: Cancer Causes & Control: CCC
Meng-Han Tsai, Steven S Coughlin
BACKGROUND: To examine the impact of county-level colorectal cancer (CRC) screening rates on stage at diagnosis of CRC and identify factors associated with stage at diagnosis across different levels of screening rates in rural Georgia. METHODS: We performed a retrospective analysis utilizing data from 2004 to 2010 Surveillance, Epidemiology, and End Results Program. The 2013 United States Department of Agriculture rural-urban continuum codes were used to identify rural Georgia counties...
April 8, 2024: Cancer Causes & Control: CCC
Jada Roach, Allyson Tabaczynski, William Goodman, Linda Trinh
PURPOSE: Exercise is beneficial for people living with and beyond cancer (LWBC); however, many people LWBC fail to meet the exercise guidelines. Having an identity related to exercise, a component of one's self-concept, correlates with exercising more frequently in general adult populations. Understanding how exercise identity influences exercise behaviors in people LWBC is warranted due to the many barriers people LWBC face in relation to physical activity. The purpose of this study was to explore the perceived impact of an exercise identity of the exercise behaviors and motivations among people LWBC...
April 7, 2024: Cancer Causes & Control: CCC
Camilla Sköld, Sara Corvigno, Hanna Dahlstrand, Gunilla Enblad, Artur Mezheyeuski, Inger Sundström-Poromaa, Karin Stålberg, Anna Tolf, Ingrid Glimelius, Anthoula Koliadi
PURPOSE: High-grade serous ovarian cancer (HGSC) is the most common ovarian cancer subtype. Parity is an important risk-reducing factor, but the underlying mechanism behind the protective effect is unclear. Our aim was to study if the expression of hormones and proteins involved in pregnancy were affected by the woman's parity status, and if they may be associated with tumor stage and survival. METHODS: We evaluated expression of progesterone receptor (PR), progesterone receptor membrane component 1 (PGRMC1), relaxin-2, and transforming growth factor beta 1 (TGFβ1) in tumor tissue from 92 women with HGSC parous (n = 73) and nulliparous (n = 19)...
April 5, 2024: Cancer Causes & Control: CCC
Helen T Orimoloye, Ya-Hui Hu, Noah Federman, Beate Ritz, Onyebuchi A Arah, Chung-Yi Li, Pei-Chen Lee, Julia E Heck
BACKGROUND: Childhood cancers are associated with high mortality and morbidity, and some maternal prescription drug use during pregnancy has been implicated in cancer risk. There are few studies on the effects of hypertension, preeclampsia, and the use of antihypertensives in pregnancy on children's cancer risks. OBJECTIVE: This population-based cohort study analyzed the relationship between hypertension, preeclampsia, and antihypertensives taken during pregnancy and the risks of childhood cancers in the offspring...
April 1, 2024: Cancer Causes & Control: CCC
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