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Cancer Causes & Control: CCC

Akemi T Wijayabahu, Zhi Zhou, Robert L Cook, Babette Brumback, Nicole Ennis, Lusine Yaghjyan
PURPOSE: The prevalence of non-AIDS-related malignancies is on the rise among people aging with HIV population, but the evidence on healthy behaviors including cancer screening practices in this population subgroup is extremely limited. Therefore, we investigated the prevalence of healthy behaviors and sex-specific cancer screening among persons living with HIV, by sex and time since HIV diagnosis. METHODS: We included 517 persons living with HIV from the Florida Cohort...
February 9, 2019: Cancer Causes & Control: CCC
Adrian Rosenberg, Oluwarotimi S Nettey, Pooja Gogana, Ujalla Sheikh, Virgilia Macias, Andre Kajdacsy-Balla, Roohollah Sharifi, Rick A Kittles, Adam B Murphy
PURPOSE: To investigate the correlation between serum 25 hydroxyvitamin D, prostatic 25 hydroxyvitamin D, and serum 1,25 dihydroxyvitamin D, and their respective associations with prostatic tumor proliferation at the time of radical prostatectomy. METHODS: In this cross-sectional analysis of 119 men undergoing radical prostatectomy, serum from whole blood and expressed prostatic fluid was collected on the day of surgery. Tumor proliferation was measured in the dominant tumor on formalin-fixed prostatectomy tissues by immunohistochemical staining for Ki67 and quantified by Aperio imaging analysis...
February 7, 2019: Cancer Causes & Control: CCC
Kyeezu Kim, Angela Kong, Robert C Flanigan, Marcus L Quek, Courtney M P Hollowell, Patricia P Vidal, Jefferey Branch, Leslie A Dean, Virgilia Macias, Andre A Kajadacsy-Balla, Marian L Fitzgibbon, Daisy Cintron, Li Liu, Vincent L Freeman
PURPOSE: An association between dietary carbohydrate intake and prostate cancer (PCa) prognosis is biologically plausible, but data are scarce. This prospective cohort study examined the relation between pre-diagnostic carbohydrate intake and treatment failure following radical prostatectomy for clinically early-stage PCa. METHODS: We identified 205 men awaiting radical prostatectomy and assessed their usual dietary intake of carbohydrates using the 110-item Block food frequency questionnaire...
February 7, 2019: Cancer Causes & Control: CCC
Hermine Poghosyan, Samuel V Scarpino
PURPOSE: This cross-sectional study examined whether food insecurity among cancer survivors is associated with smoking status and quit attempt. METHODS: Data from the 2015 behavioral risk factor surveillance system, social context module on 6,481 adult cancer survivors, were used in this study. Outcome variables were smoking status and quit attempt. Key independent variable was food insecurity. We estimated adjusted odds ratios (AOR) and 95% confidence intervals (CI) using weighted multivariable logistic regression models while controlling for individual-level demographic, socioeconomic, clinical, and behavioral characteristics...
February 7, 2019: Cancer Causes & Control: CCC
Adepitan A Owosho, Miguel Velez, Alexander Tyburski, John Hofheins, Rashidah Wiley, Tessie Stansbury, Semiu O Gbadamosi, Jon S Ryder
BACKGROUND: This study examines the epidemiological trends of oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC) in Northern New England. METHODS: Data were obtained from the Maine, New Hampshire and Vermont cancer registries. The age-standardized incidence rates (ASIR), age-specific incidence rates, and annual percentage changes (APC) for OPSCC and OCSCC were calculated using Joinpoint regression. RESULTS: The overall ASIR for OPSCC in Northern New England increased by 54...
February 7, 2019: Cancer Causes & Control: CCC
Kagan Griffin, Ilona Csizmadi, Lauren E Howard, Gina-Maria Pomann, William J Aronson, Christopher J Kane, Christopher L Amling, Matthew R Cooperberg, Martha K Terris, Jennifer Beebe-Dimmer, Stephen J Freedland
PURPOSE: We aimed to study the associations between androgen-deprivation therapy (ADT)-induced weight changes and prostate cancer (PC) progression and mortality in men who had undergone radical prostatectomy (RP). METHODS: Data from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort were used to study the associations between weight change approximately 1-year post-ADT initiation and metastases, castration-resistant prostate cancer (CRPC), all-cause mortality (ACM), and PC-specific mortality (PCSM) in 357 patients who had undergone RP between 1988 and 2014...
January 30, 2019: Cancer Causes & Control: CCC
Margaret C Fahey, Zoran Bursac, Jon O Ebbert, Robert C Klesges, Melissa A Little
PURPOSE: Tobacco use in cancer survivors remains a significant problem, however, the use of non-cigarette tobacco products (NCTPs) in this population is less understood. This study examined prevalence and correlates of tobacco use among cancer survivors who were never, current, and former cigarette users. Tobacco-related behaviors and quitting attitudes were compared between survivors dually using cigarettes and electronic cigarettes (ECs) and cigarette-only users. METHODS: In this cross-sectional study, patients at Mid-South cancer centers (n = 629; 50...
January 22, 2019: Cancer Causes & Control: CCC
Oliver W Scott, Sandar Tin Tin, Susan M Bigby, J Mark Elwood
PURPOSE: Endometrial cancer accounts for 3.9% of all female cancers globally, and its incidence appears to be increasing in women under 40 years of age. This paper investigated ethnic-specific trends in endometrial cancer across different age groups in New Zealand. METHODS: Women who were diagnosed with endometrial cancer between 1996 and 2012 were identified from the New Zealand Cancer Registry. Annual age-standardized incidence and mortality rates were calculated for each ethnicity (Māori, Pacific, and non-Māori non-Pacific) in four age groups (< 40, 40-49, 50-74, and 75 +)...
January 22, 2019: Cancer Causes & Control: CCC
Sania Amr, Beverly J Wolpert, Diane Marie St George, India James, Christopher A Loffredo
PURPOSE: Investigators have reported inconsistent findings regarding associations between body mass index (BMI) and bladder cancer risk, and they have postulated that sex steroids mediate such associations. We assessed the impact of BMI on the relationship between bladder cancer risk and combinations of age at first childbirth, parity, and age at menopause, among Egyptian women. METHODS: We used data from our multicenter case-control study of 419 cases and 786 controls in logistic regression models to estimate adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of such associations...
January 21, 2019: Cancer Causes & Control: CCC
Bijou R Hunt, Abigail Silva, Derrick Lock, Marc Hurlbert
PURPOSE: We employed a city-level ecologic analysis to assess predictors of race-specific (black and white) breast cancer mortality rates. METHODS: We used data from the National Center for Health Statistics and the US Census Bureau to calculate 2010-2014 race-specific breast cancer mortality rates (BCMR) for 47 of the largest US cities. Data on potential city-level predictors (e.g., socioeconomic factors, health care resources) of race-specific BCMR were obtained from various publicly available datasets...
January 17, 2019: Cancer Causes & Control: CCC
Marilyn L Kwan, Lawrence H Kushi, Kim N Danforth, Janise M Roh, Isaac J Ergas, Valerie S Lee, Kimberly L Cannavale, Teresa N Harrison, Richard Contreras, Ronald K Loo, David S Aaronson, Charles P Quesenberry, David Tritchler, Nirupa R Ghai, Virginia P Quinn, Christine B Ambrosone, Yuesheng Zhang, Li Tang
PURPOSE: Bladder cancer is one of the top five cancers diagnosed in the U.S. with a high recurrence rate, and also one of the most expensive cancers to treat over the life-course. However, there are few observational, prospective studies of bladder cancer survivors. METHODS: The Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be-Well Study) is a National Cancer Institute-funded, multi-center prospective cohort study of non-muscle-invasive bladder cancer (NMIBC) patients (Stage Ta, T1, Tis) enrolled from the Kaiser Permanente Northern California (KPNC) and Southern California (KPSC) health care systems, with genotyping and biomarker assays performed at Roswell Park Comprehensive Cancer Center...
January 17, 2019: Cancer Causes & Control: CCC
Schelomo Marmor, Bonnie Jerome-D'Emilia, James W Begun, Jane Yuet Ching Hui, Ariella M Altman, Scott Kizy, Todd M Tuttle
PURPOSE: The diagnosis of lobular carcinoma in situ (LCIS) is a strong risk factor for breast cancer. Endocrine therapy (ET) for LCIS has been shown to decrease breast cancer risk substantially. The purpose of this study was to evaluate the trends of ET use for LCIS in two large geographic locations. PATIENTS AND METHODS: We identified women, ages 18 through 75, with a microscopic diagnosis of LCIS in California (CA) and New Jersey (NJ) from 2004 to 2014. We evaluated trends in unadjusted ET rates during the study period and used logistic regression to evaluate the relationship between patient, tumor, and treatment characteristics, and ET use...
January 17, 2019: Cancer Causes & Control: CCC
D Zakaria, A Shaw
PURPOSE: The purpose of the study is to examine relationships between long-term trends of region- and age-specific rates of mammography, hormone replacement therapy (HRT), and breast cancer incidence and mortality in Canadian women aged 35 years and older. METHODS: Population-based complex surveys were used to estimate mammography use in the past 2 years and ever, and HRT use in the past month. National population-based administrative data were used to estimate breast cancer incidence and mortality...
January 14, 2019: Cancer Causes & Control: CCC
Lindsay A Williams, Katherine A Hoadley, Hazel B Nichols, Joseph Geradts, Charles M Perou, Michael I Love, Andrew F Olshan, Melissa A Troester
BACKGROUND: The dominant invasive breast cancer histologic subtype, ductal carcinoma, shows intrinsic subtype diversity. However, lobular breast cancers are predominantly Luminal A. Both histologic subtypes show distinct relationships with patient and tumor characteristics, but it is unclear if these associations remain after accounting for intrinsic subtype. METHODS: Generalized linear models were used to estimate relative frequency differences (RFDs) and 95% confidence intervals (95% CIs) for the associations between age, race, tumor characteristics, immunohistochemistry (IHC) and RNA-based intrinsic subtype, TP53 status, and histologic subtype in the Carolina Breast Cancer Study (CBCS, n = 3,182) and The Cancer Genome Atlas (TCGA, n = 808)...
January 8, 2019: Cancer Causes & Control: CCC
Catherine L Callahan, Matthew R Bonner, Jing Nie, Youjin Wang, Meng-Hua Tao, Peter G Shields, Catalin Marian, Kevin H Eng, Maurizio Trevisan, Jo L Freudenheim
PURPOSE: Tobacco smoke exposure has been associated with altered DNA methylation. However, there is a paucity of information regarding tobacco smoke exposure and DNA methylation of breast tumors. METHODS: We conducted a case-only analysis using breast tumor tissue from 493 postmenopausal and 225 premenopausal cases in the Western New York Exposures and Breast Cancer (WEB) study. Methylation of nine genes (SFN, SCGB3A1, RARB, GSTP1, CDKN2A, CCND2, BRCA1, FHIT, and SYK) was measured with pyrosequencing...
January 7, 2019: Cancer Causes & Control: CCC
Nikki S Hayes, Karin Hohman, Cynthia Vinson, Mandi Pratt-Chapman
In order to celebrate the accomplishments of the Centers for Disease Control and Prevention's (CDC) National Comprehensive Cancer Control Program (NCCCP), the Comprehensive Cancer Control National Partners (CCCNP) developed this Special Issue on Cancer Causes and Control. This, the third Special Issue on Comprehensive Cancer Control (CCC), is a reflection of 20 years of building successful partnerships to prevent and control cancer; planning and implementing strategic cancer control; collaborating to address national cancer prevention and control priorities; evaluating efforts; sharing successes; and, in later years, serving as a model for global cancer control planning and implementation...
December 19, 2018: Cancer Causes & Control: CCC
Ulrika Andersson, Sofie Degerman, Anna M Dahlin, Carl Wibom, Gunnar Johansson, Melissa L Bondy, Beatrice S Melin
PURPOSE: Previous studies have suggested an association between relative leukocyte telomere length (rLTL) and glioma risk. This association may be influenced by several factors, including allergies, BMI, and smoking. Previous studies have shown that individuals with asthma and allergy have shortened relative telomere length, and decreased risk of glioma. Though, the details and the interplay between rLTL, asthma and allergies, and glioma molecular phenotype is largely unknown. METHODS: rLTL was measured by qPCR in a Swedish population-based glioma case-control cohort (421 cases and 671 controls)...
December 17, 2018: Cancer Causes & Control: CCC
Leslie S Given, Karin Hohman, Brenda Kostelecky, Cynthia Vinson
The development of cancer control plans as a clearly defined concept began in the U.S. in the early 1990s. On an international level, the same concept has been described as "national cancer control planning" or national cancer control plan (NCCP) development and implementation. Recent efforts by the National Cancer Institute's Center for Global Health and its partners have increased international and country-level interest in NCCPs. Central to the development of these plans has been a need for countries to understand the crucial factors and foundational elements necessary to develop and successfully implement a national cancer plan...
December 15, 2018: Cancer Causes & Control: CCC
Florence K L Tangka, Sujha Subramanian, Sonja Hoover, Christen Lara, Casey Eastman, Becky Glaze, Mary Ellen Conn, Amy DeGroff, Faye L Wong, Lisa C Richardson
Use of recommended screening tests can reduce new colorectal cancers (CRC) and deaths, but screening uptake is suboptimal in the United States (U.S.). The Centers for Disease Control and Prevention (CDC) funded a second round of the Colorectal Cancer Control Program (CRCCP) in 2015 to increase screening rates among individuals aged 50-75 years. The 30 state, university, and tribal awardees supported by the CRCCP implement a range of multicomponent interventions targeting health systems that have low CRC screening uptake, including low-income and minority populations...
December 14, 2018: Cancer Causes & Control: CCC
Sophie E Mayer, Noel S Weiss, Jessica Chubak, David R Doody, Christopher S Carlson, Karen W Makar, Michelle A Wurscher, Kathleen E Malone
PURPOSE: Tamoxifen is widely used to reduce the risk of breast cancer (BC) recurrence and extend disease-free survival among women with estrogen-sensitive breast cancers. Tamoxifen efficacy is thought to be attributable to its active metabolite, which is formed through a reaction catalyzed by the P450 enzyme, CYP2D6. Inhibition of tamoxifen metabolism as a result of germline genetic variation and/or use of CYP2D6-inhibiting medications ("inhibitors") is hypothesized to increase the risk of adverse BC outcomes among women taking tamoxifen...
December 12, 2018: Cancer Causes & Control: CCC
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