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Journals Indian Journal of Clinical Bio...

Indian Journal of Clinical Biochemistry : IJCB

https://read.qxmd.com/read/37234189/inborn-metabolic-disorders-the-winding-path-ahead-in-the-road-less-traveled
#1
EDITORIAL
K Vaidyanathan
No abstract text is available yet for this article.
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234188/assessment-of-vitamin-d-levels-and-other-bone-related-biochemical-markers-in-healthy-adults-in-rural-population-of-uttarakhand-india
#2
JOURNAL ARTICLE
Anissa Atif Mirza, Himani Rathi, Senkadhirdasan Dakshinamurthy, Bela Goyal, Sarama Saha, Vartika Saxena, Vasantha Kalyani, Raman Kumar, Manisha Naithani
UNLABELLED: Despite being close to equator and receiving sufficient sun rays, evidences revealed that Indians have severe deficiency of vitamin D (vit D) ranging from 41 to 100% in different geographical locations. Therefore, in this study levels of 25(OH)D (physiologically measurable form) along with other bone metabolism associated biochemical markers were determined in serum sample of 300 apparently healthy study subjects (rural) from Doiwala block of Dehradun district in the state of Uttarakhand...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234186/nanoencapsulation-of-docetaxel-induces-concurrent-apoptosis-and-necroptosis-in-human-oral-cancer-cells-scc-9-via-tnf-%C3%AE-rip1-rip3-pathway
#4
JOURNAL ARTICLE
Parul Gupta, Arpita Singh, Ajay Kumar Verma, Surya Kant, Anuj Kumar Pandey, Anupam Mishra, Puneet Khare, Ved Prakash
Human oral squamous cell carcinoma is the sixth most frequent malignant cancer, with an unacceptably high death rate that affects people's health. Albeit, there are several clinical approaches for diagnosing and treating oral cancer they are still far from ideal. We previously synthesised and characterised the docetaxel nanoformulation (PLGA-Dtx) and discovered that docetaxel nanoencapsulation may suppress oral cancer cells. The goal of this study was to figure out the mechanism involved in the suppression of oral cancer cell proliferation...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234185/impact-of-rs2107425-polymorphism-and-expression-of-lnch19-and-mir-200a-on-the-susceptibility-of-colorectal-cancer
#5
JOURNAL ARTICLE
Ebtsam Hamed Khalil, Olfat G Shaker, Nabil A Hasona
Cancer is the most common leading cause of mortality, making it a critical public health issue worldwide. Environmental and genetic abnormalities play a role in carcinogenesis, characterized by single nucleotide polymorphisms (SNPs) and abnormal gene expression. Also, non-coding RNA is a hot spot in cancer growth and metastasis. This study aimed to demonstrate the contribution of LncRNA H-19 rs2107425 to colorectal cancer (CRC) susceptibility and the correlation between miR-200a and LncRNA H-19 in patients with CRC...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234184/leadcare%C3%A2-ii-comparison-with-graphite-furnace-atomic-absorption-spectrophotometry-for-blood-lead-measurement-in-peruvian-highlands
#6
JOURNAL ARTICLE
Jaime Rosales-Rimache, Manuel Chavez-Ruiz, Jorge Inolopú-Cucche, Jhonatan Rabanal-Sanchez, Lenin Rueda-Torres, Gloria Sanchez-Holguin
Peru is one of the countries with the highest lead contamination in the world. Biological monitoring has limitations due to the shortage of laboratories with validated methodologies for the measurement of blood lead, and it is necessary to use alternative methods for its measurement in high-altitude cities. We aimed to compare the blood lead levels (BLL) measured by the LeadCare II (LC) method and Graphite Furnace Atomic Absorption Spectrometry (GF-AAS). We measured the BLL of 108 children from the city of La Oroya...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234183/atypical-case-of-highly-mutated-h-tert-promoter-in-germline-genome-from-buccal-mucosa-cancer
#7
Rajendra Prasad, Sonia Panchal, Isha Rani, Gaurav Parashar, Jai Kishan, Mini Bhatnagar
Buccal mucosa cancer has an aggressive nature as it rapidly grows and penetrates with high recurrence rate. Strikingly, carcinoma of buccal mucosa is the most common cancer of oral cavity in India. Recently, telomerase and telomere biology have been implicated in the pathogenesis and progression in various cancers via regulation of telomere maintenance by telomerase expression which is controlled by telomerase reverse transcriptase (TERT) promoter. Strikingly, h-TERT promoter mutations have been incriminated in regulation of telomerase gene expression...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234182/the-kl-genetic-polymorphisms-associated-with-type-2-diabetes-mellitus
#8
JOURNAL ARTICLE
Hyun-Seok Jin, Dongju Jung
Growing number of research studies have shown that an anti-ageing gene Klotho ( KL ) is closely associated with Type 2 Diabetes Mellitus (T2DM). In this study, the association is genetically analyzed with single nucleotide polymorphism (SNP) of KL found in T2DM case of an Asian cohort. KL SNP information was obtained from a big database of the Korean Association Resource (KARE) from which 20 KL SNPs were available. Statistical analyses were conducted based on the 3 genetic models, such as additive, dominant, and recessive...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234181/association-of-micronutrients-with-tuberculosis-development-in-hiv-infected-patients
#9
JOURNAL ARTICLE
Dinesh Banyal, Sumedha Sharma, Anil Kumar Ram, Khushpreet Kaur, Ravjit Singh Jassal, Savita Attri, Aman Sharma, Kusum Sharma, Suman Laal, Indu Verma
Human immunodeficiency virus (HIV) infection associated with weakened immune system due to decreased CD4 T cell count favors development of tuberculosis. Effector immune responses are also associated with micronutrient status due to their prominent role in maintaining immune functions. Micronutrient deficiencies are quite common among HIV patients that further result into compromised immunity thus making the conditions even more favorable for mycobacteria to establish disease. So, current study was designed to assess association of different micronutrients with development of TB in HIV patients...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234180/a-comparative-analysis-of-effectiveness-of-recombinant-interleukin-11-versus-papaya-leaf-extract-for-treatment-of-thrombocytopenia-a-review
#10
REVIEW
K P Mishra, Jyotsana Bakshi, Gitika Sharma, Somnath Singh, Usha Panjwani
Platelets or thrombocytes play an important role in thrombosis and maintaining hemostasis. Thrombocytes help in forming blood clots at the site of the wound. When the level of platelets decreases, uncontrolled bleeding occurs which can result in mortality. A decrease in the blood platelet level is known as thrombocytopenia which can be caused due to various reasons. A variety of treatment options are available for thrombocytopenia like platelet transfusion, splenectomy, platelet management with various types of corticosteroids, and recombinant interleukin-11 (rhIL-11)...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37234179/correlation-of-wilms-tumor-1-wt1-with-oxidative-stress-markers-and-expression-of-mir-361-5p-new-aspect-of-wt1-in-breast-cancer
#11
JOURNAL ARTICLE
Fariba Pishbin, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Rezvan Najafi, Maryam Farhadian
Breast carcinoma is a heterogeneous disease that affects millions of women worldwide. Wilms' tumor 1 (WT1) is an oncogene that promotes proliferation, metastasis and reduces apoptosis. MicroRNAs (miR) are short noncoding RNAs with a major role in cancer metastasis. In present study, we investigated the association of serum level of WT1 with oxidative stress and expression of miR-361-5p in breast cancer. Serum samples of 45 patients and of 45 healthy women analyzed for protein level of WT1, malondialdehyde (MDA), total oxidant status (TOS), and total antioxidant capacity (TAC)...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37223306/a-pilot-study-on-blood-components-in-covid-19-affected-subjects-a-correlation-to-upr-signalling-and-er-stress
#12
JOURNAL ARTICLE
Akash Bansal, Sushil Kumar, Neha Rai, Shilpi Kumari, Visesh Kumar, Ajeet Kumar, Nimai Chand Chandra
ABSTRACT: The endoplasmic reticulum (ER) is the site for protein synthesis, its folding and secretion. An intricate set of signalling pathways, called UPR pathways, have been evolved by ER in mammalian cells, to allow the cell to respond the presence of misfolded proteins within the ER. Breaching of these signalling systems by disease oriented accumulation of unfolded proteins may develop cellular stress. The aim of this study is to explore whether COVID-19 infection is responsible for developing this kind of endoplasmic reticulum related stress (ER-stress)...
July 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37360645/long-term-treatment-of-corticostreroids-may-cause-hepatotoxicity-and-oxidative-damage-a-case-controlled-study
#13
JOURNAL ARTICLE
Priyanka Tiwari, Nitika Singh, Bechan Sharma
Arthritis is a clinical condition, which mainly affects the structure and function joints. During this condition the joints gets swelled and stiffed resulting into development of pain and morbidity. Corticosteroids are frequently prescribed to manage various clinical conditions including the chronic inflammatory diseases such as arthritis. The steroidal drug also causes certain adverse effects depending on the dose, the route of administration and duration of treatment. However, a systematic investigation on the biochemical consequences of steroids as a therapeutic has not been carried out...
April 1, 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025434/correlation-of-body-mass-index-with-anthropometric-and-biochemical-parameters-among-polycystic-ovary-syndrome-phenotypes
#14
JOURNAL ARTICLE
Tanuja Mehra, Sonali Sharma, Tasneem Zahra, Sapna Jangir, Barkha Gupta
This was a prospective observational study, conducted at a tertiary care health centre in Rajasthan. A total of 68 women with PCOS (Rotterdam criteria) attending OPD at Department of Obstetrics and Gynecology qualified as per inclusion and exclusion criteria were included in the study. Each participant was examined for anthropometric and biochemical parameters. The largest phenotypic group was phenotype A, (41.17%); followed by B (26.47%); C (20.58%), and D (P + O) phenotypes (11.76%). Hyperandrogenic phenotypes (A, B, C), had significantly higher prevalence of deranged serum glucose (fasting and postprandial), lipid profile and serum TSH than normoandrogenic phenotype D...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025433/smouldering-myeloma-chasing-a-hyperviscous-sample
#15
Amandeep Birdi, Arun Sinha, Mithu Banerjee, Maithili Karpaga SelviN
Serum hyperviscosity is a rare laboratory finding. Amongst several causes of serum hyperviscosity, malignant disorders are quite common. Monoclonal gammopathy is a family of disorders in which monoclonal gammopathy of unknown significance (MGUS) and smoldering myeloma are the asymptomatic variants whereas multiple myeloma is the malignant variant showing different signs and symptoms related to bone lesions, renal failure and anemia. Initially during sample preparation, pipetting of a serum sample was found to be cumbersome...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025432/cancer-stem-cells-future-possibilities-for-cancer-therapy
#16
EDITORIAL
Shailendra Dwivedi, Praveen Sharma
No abstract text is available yet for this article.
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025431/development-of-dna-bio-chip-for-detection-of-mutations-of-rpob-embb-and-inha-genes-in%C3%A2-drug-resistant-mycobacterium-tuberculosis
#17
JOURNAL ARTICLE
Bharti Jain, Savita Kulkarni
Drug-resistant (DR) tuberculosis (TB) is a global threat to health security and TB control programs. Since conventional drug susceptibility testing (DST) takes several weeks, we have developed a molecular method for the rapid identification of DR strains of Mycobacterium Tuberculosis (M.tb) utilizing DNA bio-chips. DNA bio-chips were prepared by immobilizing oligonucleotides (probes) on highly microporous polycarbonate track-etched membranes (PC-TEM) as novel support. Bio-chip was designed to contain 15 specific probes to detect mutations in three genes ( rpoB, embB, and inhA )...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025430/hepatoprotective-effect-of-ethanolic-extract-of-garlic-against-reserpine-induced-toxicity-in-wistar-rats
#18
JOURNAL ARTICLE
Khushboo, Vivek Kumar Gupta, Bechan Sharma
Reserpine, a bioactive compound isolated from the roots of Rauwolfia serpentine , is known to deplete dopamine, a neurotransmitter. The clinical application of reserpine has been associated to manage hypertension, insanity, insomnia and schizophrenia. However, the usage of reserpine as a drug is restricted because of its ability of inducing excess free radicals production and oxidative stress resulting into damage to liver and other organs. Here, we have explored the antioxidative potential of extract of garlic prepared using ethanol (EEG) against reserpine-induced hepatic damage in the albino Wister rats...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/37025429/association-of-catechol-o-methyltransferase-gene-polymorphisms-and-haplotypes-in-the-levodopa-induced-adverse-events-in-subjects-with-parkinson-s-disease
#19
JOURNAL ARTICLE
Tasneem Sd Fatima, Syed Tazeem Fathima, Rukmini Mridula Kandadai, Rupam Borgohain, Boddupally Sreenu, Vijay Kumar Kutala
The presence of dyskinesia is the most common side effect of chronic administration of levodopa in Parkinson's disease (PD) subjects. Genetic polymorphisms in levodopa metabolizing gene, catechol-O-methyl transferase (COMT), is shown to influence the inter-individual variability in drug response and adverse events. In the present study, the association of COMT rs6269, rs4633, rs4818, and rs4680 polymorphisms and haplotypes on pharmacokinetics and adverse events with levodopa was investigated in 150 PD patients...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
https://read.qxmd.com/read/36816717/coagulopathy-is-initiated-with-endothelial-dysfunction-and-disrupted-fibrinolysis-in-patients-with-covid-19-disease
#20
JOURNAL ARTICLE
Fatma Burcu Belen Apak, Gulbahar Yuce, Deniz Ilhan Topcu, Ayse Gultekingil, Yunus Emre Felek, Tugce Sencelikel
UNLABELLED: A substantial group of patients suffer from Covid-19 (CAC) coagulopathy and are presented with thrombosis. The pathogenesis involved in CAC is not fully understood. We evaluated the hemostatic and inflammatory parameters of 51 hospitalized Covid-19 adult patients and 21 controls. The parameters analyzed were danger signal molecule (High molecular weight group box protein-1/HMGBP-1), platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer, fibrinogen, endothelial protein C receptor (EPCR), soluble E-selectin, soluble P-selectin, thrombomodulin, tissue plasminogen activator (TPA), plasminogen activator inhibitor-1 (PAI-1), soluble fibrin monomer complex (SFMC), platelet-derived microparticles (PDMP), β-thromboglobulin, antithrombin and protein C...
April 2023: Indian Journal of Clinical Biochemistry: IJCB
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