Erika Iervasi, Antonella Strangio, Luigi Greco, Renata Auricchio, Daniele Saverino
Celiac disease (CD) is an autoimmune disease with inflammatory characteristics, having a condition of chronic malabsorption, affecting approximately 1% of the population at any age. In recent years, a concrete correlation between eating disorders and CD has emerged. Hypothalamus plays a central role in determining eating behaviour, regulating appetite and, consequently, food intake. One hundred and ten sera from celiac patients (40 active and 70 following a gluten-free diet) were tested for the presence of autoantibodies against primate hypothalamic periventricular neurons by immunofluorescence and by a home-made ELISA assay...
May 23, 2023: Immunologic Research
Li Zhou, Hui Lian, Yue Yin, Yuan-Sheng Zheng, Yu-Xin Han, Gao-Qi Liu, Zhi-Yong Wang
Muscularis macrophages, as the most abundant immune cells in the intestinal muscularis externa, exhibit tissue protective phenotype in the steady state. Owing to tremendous advances in technology, we now know the fact that muscularis macrophages are a heterogeneous population of cells which could be divided into different functional subsets depending on their anatomic niches. There is emerging evidence showing that these subsets, through molecular interactions with their neighbours, take part in a wide range of physiological and pathophysiological processes in the gut...
May 23, 2023: Immunologic Research
Iyengar Vaishnavi Venkatachari, Akshaya Chougule, Vijaya Gowri, Prasad Taur, Minnie Bodhanwala, Shakuntala Prabhu, Manisha Madkaikar, Mukesh Desai
To estimate the prevalence of monogenic inborn errors of immunity in patients with autoimmune diseases (AID), the study included 56 subjects (male:female ratio: 1.07) with mean age of onset of autoimmunity 7 years (4 months-46 years). 21/56 had polyautoimmunity. 5/56 patients met the JMF criteria for PID. The different AID referred were hematological (42%) > gastrointestinal (GI) (16%) > skin (14%) > endocrine (10%) > rheumatological (8%) > renal (6%) > neurological (2%). 36/56 reported recurrent infections...
May 18, 2023: Immunologic Research
Laura Martinez-Martinez, Juan Irure-Ventura, Aurora Jurado, Garbiñe Roy, Marco Antonio Montes, Yvelise Barrios, Beatriz Rodríguez-Bayona, Esther Vergara, Álvaro Prada, Ricardo Rojo, María Luisa Vargas
Antinuclear antibodies (ANA) are the most widely used immunological test for the diagnosis of autoimmune diseases. Despite the recommendations of experts, there is some variability in performing and interpreting this test in routine practice. In this context, the Spanish Group on Autoimmune Diseases (GEAI) of the Spanish Society of Immunology (SEI) conducted a national survey of 50 autoimmunity laboratories. Here we report the survey results on ANA testing, detection of related antigens, and our recommendations...
May 17, 2023: Immunologic Research
Cecilia Zivelonghi, Alessandro Dinoto, Sarosh R Irani, Andrew McKeon, Andrea Pilotto, Alessandro Padovani, Stefano Masciocchi, Eugenio Magni, Chiara R Mancinelli, Ruggero Capra, Giorgia T Maniscalco, Irene Volonghi, Ava Easton, Daniela Alberti, Gianluigi Zanusso, Salvatore Monaco, Gian Luca Salvagno, Giuseppe Lippi, Sergio Ferrari, Sara Mariotto
It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether SARS-CoV-2 infection induces similar conditions and whether they show a distinctive phenotype. We retrospectively identified patients with acute inflammatory CNS conditions referred to our laboratory for antibody testing during the pandemic (March 1 to August 31, 2020). We screened SARS-COV-2 IgA/IgG in all sera by ELISA and confirmed the positivity with additional assays...
May 12, 2023: Immunologic Research
Karin Warshavsky, Tal Zeeli, Ori Mekiten, Eli Sprecher, Barbara G Silverman, Aviv Barzilai, Sharon Baum
Pemphigus vulgaris (PV) is a rare autoimmune intraepidermal bullous disease. PV has a major effect on morbidity as well as quality of life. There is sparse literature regarding the association between pemphigus vulgaris (PV) and comorbid malignancies. In this study we aimed to assess the risk of malignancy in a cohort of patients with PV and characterize PV-associated malignancies. Data were collected from two tertiary referral centers between the years 2008 and 2019 and compared with the national cancer registry...
May 4, 2023: Immunologic Research
Edoardo Conticini, Miriana d'Alessandro, Paolo Cameli, Laura Bergantini, Elena Pordon, Lucia Cassai, Luca Cantarini, Elena Bargagli, Bruno Frediani, Brunetta Porcelli
The presence of interstitial lung disease (ILD) is a common and fearsome feature of idiopathic inflammatory myopathies (IIM). Such patients show radiological pattern of non-specific interstitial pneumonia (NSIP). The present study aimed to assess the prevalence of myositis-specific and myositis-associated antibodies (MSA and MAA) in a cohort of patients with a previous diagnosis of NSIP and no sign or symptom of IIM. Secondly, it will be assessed whether patients displaying MSA and/or MAA positivity have a worse or a better outcome than idiopathic NSIP...
May 3, 2023: Immunologic Research
Sílvia Torrents, Andrés Escudero Del Moral, Margarita Codinach, Luciano Rodríguez, Sergi Querol, Joaquim Vives
Multipotent mesenchymal stromal cells (MSC) offer new therapeutic opportunities based on their ability to modulate an imbalanced immune system. Immunomodulatory potency is typically demonstrated in vitro by measuring the presence of surrogate markers (i.e., indoleamine-2,3-dioxygenase, IDO; tumor necrosis factor receptor type 1, TNFR1) and/or functional assays in co-cultures (i.e., inhibition of lymphoproliferation, polarization of macrophages). However, the biological variability of reagents used in the latter type of assays leads to unreliable and difficult to reproduce data therefore making cross-comparison between batches difficult, both at the intra- and inter-laboratory levels...
April 29, 2023: Immunologic Research
Woorim Kim, Ha Rim Yeon, Jun Hyeob Kim, Joo Hee Kim, Ji Hyoun Kim, Hyoun-Ah Kim, Ju-Yang Jung, Jinhyun Kim, In Ah Choi, Kyung Eun Lee
Rheumatoid arthritis (RA) is a severe chronic inflammatory condition that affects joint synovium. Suppressor/enhancer of lin-12-like (SEL1L)-Synoviolin 1 (SYVN1)-mediated endoplasmic reticulum-associated degradation (ERAD) is highly associated with RA development. Although targeting SEL1L-SYVN1-mediated ERAD can be beneficial, studies that evaluate the association between polymorphisms in their genes and remission from the disease in RA patients taking tumor necrosis factor (TNF)-α inhibitors have yet to be carried out...
April 29, 2023: Immunologic Research
Kevin Roe
No abstract text is available yet for this article.
April 27, 2023: Immunologic Research
Shima Izadi, Sayed Reza Najfizadeh, Ahmad Nejati, Majid TeimooriRad, Shohreh Shahmahmoodi, Frough Golsaz Shirazi, Fazel Shokri, Sayed Mahdi Marashi
SLE is a multisystem autoimmune disease characterized by multiple immunological abnormalities including production of autoantibodies. While the etiology of SLE is largely unknown, it is generally accepted that both genetic and environmental factors contribute to disease risk and immune dysregulation. Production of IFN-α is important for protecting the host against infections; however, over stimulation of innate immune pathways can induce autoimmune disease. Environmental factors, particularly Epstein-Barr virus (EBV), have been proposed to play an important role in SLE disease...
April 25, 2023: Immunologic Research
Jia-Ying Lin, Bing-Xue Bai
No abstract text is available yet for this article.
April 20, 2023: Immunologic Research
Camilla Mattiuzzi, Giuseppe Lippi
No abstract text is available yet for this article.
April 20, 2023: Immunologic Research
Weijie Zhang, Yiyang Li, Chuan Tian, Si Huang, Lidan Chen, Yajun Wang, Guoda Ma, Riling Chen
No abstract text is available yet for this article.
April 17, 2023: Immunologic Research
Sneh Lata Gupta, Surbhi Goswami, Ananya Anand, Namrata Naman, Priya Kumari, Priyanka Sharma, Rishi K Jaiswal
The COVID-19 disease continues to cause devastation for almost 3 years of its identification. India is one of the leading countries to set clinical trials, production, and administration of COVID-19 vaccination. Recent COVID-19 vaccine tracker record suggests that 12 vaccines are approved in India, including protein subunit, RNA/DNA, non-replicating viral vector, and inactivated vaccine. Along with that 16 more vaccines are undergoing clinical trials to counter COVID-19. The availability of different vaccines gives alternate and broad perspectives to fight against viral immune resistance and, thus, viruses escaping the immune system by mutations...
April 11, 2023: Immunologic Research
Yongjie Qi, Chen Chen, Xuejun Li, Yi Liu, Huiqin Qi, Yingchang Xue, Fengyong Yang
This study aims to confirm whether apolipoprotein C3 (ApoC3) can regulate the inflammatory response and tissue damage in acute lung injury (ALI) and explore its regulatory pathway. ALI mouse model was established by intraperitoneal injection of lipopolysaccharide (LPS). ApoC3 levels were detected by real-time quantitative polymerase chain reaction, immunohistochemistry, and western blot assays. The levels of various inflammatory factors were detected by enzyme-linked immunosorbent assay and western blot analysis...
April 10, 2023: Immunologic Research
Jyotirmayee Dey, Soumya Ranjan Mahapatra, Pawan K Singh, Samudyata C Prabhuswamimath, Namrata Misra, Mrutyunjay Suar
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is responsible for about more than 722,000 cases in a year, globally. Despite the alarming increase in multidrug resistance, a safe and effective vaccine for Acinetobacter infections is still not available. Hence in the current study, a multiepitope vaccine construct was developed using linear B cell, cytotoxic T cell, and helper T cell epitopes from the antigenic and well-conserved lipopolysaccharide assembly proteins employing systematic immunoinformatics and structural vaccinology strategies...
April 6, 2023: Immunologic Research
Parviz Azimnasab-Sorkhabi, Maryam Soltani-Asl, Túlio Teruo Yoshinaga, Cristina de Oliveira Massoco, Jose Roberto Kfoury Junior
Cancer is classified into metabolic and/or genetic disorders; notably, the tryptophan catabolism pathway is vital in different cancer types. Here, we focused on the interaction and molecular connection between the cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptor and indoleamine-2,3-dioxygenase (IDO) enzyme. To test the impact of the selected immunotherapies on breast cancer cell migration and cell survival, we used in vitro assays. Also, we test the impact of anti-CTLA-4 antibody on the IDO-positive cells...
April 4, 2023: Immunologic Research
Kevin Roe
Most viral, bacterial, fungal, and protozoan pathogens can cause latent infections. Latent pathogens can be reactivated from any intentional medical treatment causing immune system suppression, pathogen infections, malnutrition, stress, or drug side effects. These reactivations of latent pathogen infections can be dangerous and even lethal, especially in immuno-suppressed individuals. The latent pathogen infections in an individual can be classified and updated on a periodic basis in a four category system by whether or not an individual's immune system is damaged and by whether or not these latent infections will assist other active or latent pathogen infections...
April 3, 2023: Immunologic Research
Hina Qayoom, Shazia Sofi, Manzoor A Mir
The immune system plays a vital role in suppressing tumor cell progression. The tumor microenvironment augmented with significant levels of tumor-infiltrating lymphocytes has been widely investigated and it is suggested that tumor-infiltrating lymphocytes have shown a significant role in the prognosis of cancer patients. Compared to ordinary non-infiltrating lymphocytes, tumor-infiltrating lymphocytes (TILs) are a significant population of lymphocytes that infiltrate tumor tissue and have a higher level of specific immunological reactivity against tumor cells...
April 1, 2023: Immunologic Research
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.