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Immunologic Research

Hirotoshi Kawashima, Atsunari Utsugi, Asuka Shibamiya, Kazuma Iida, Norihiro Mimura, Hirohumi Ohashi, Ryota Hase, Makio Kawakami, Takao Yanagisawa, Masaki Hiraguri
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and immunoglobulin G4-related diseases (IgG4-RD) are regarded as entirely different disease types with different etiological mechanisms. However, we experienced two cases that had clinical features of both AAV and IgG4-RD. The first case is an 81-year-old woman who showed periaortitis and retroperitoneal fibrosis and periarteritis with elevation of myeloperoxidase-anti-neutrophil cytoplasmic antibody and IgG4 levels. The second case is a 63-year-old woman who had dura mater, ear, nose, lung, and kidney involvement with serum negative for ANCA and elevated IgG4...
February 8, 2019: Immunologic Research
Shu-Ichi Ikeda, Akiyo Hineno, Kazuki Ozawa, Tomomi Kinoshita
In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalities in laboratory test results. Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago...
February 5, 2019: Immunologic Research
Shin Takasawa, Chikatsugu Tsuchida, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Asako Itaya-Hironaka, Akiyo Yamauchi, Masayasu Misu, Ryogo Shobatake, Tomoko Uchiyama, Mai Makino, Chiho Ohbayashi
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all the REG family genes in IBD is still unclear. Here, we analyzed expression of all the REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP, and REG IV) in biopsy specimens of UC and CD by real-time RT-PCR...
January 29, 2019: Immunologic Research
Johannes J Roggenbuck, Miklos Veiczi, Karsten Conrad, Peter Schierack, Gerd Wunderlich, Joerg Kotzerke, Dirk Roggenbuck, Klaus Zöphel
TSH receptor (TSHR) autoantibody (TRAb) is the serological hallmark of Graves' disease (GD). Third-generation enzyme-linked immunosorbent assays (ELISAs) using monoclonal TRAbs instead of TSH have been found useful for TRAb analysis recently. For the first time, a mouse monoclonal antibody (mAb) against TSHR was analyzed for TRAb detection and compared with human mAb M22 and TSH by the same competitive binding assay technique. A mouse monoclonal antibody (T7) binding to the TSH receptor and inhibiting TSH binding was generated and used for TRAb analysis in a third-generation ELISA...
January 26, 2019: Immunologic Research
Simon D Lytton, Marcin Osiecki, MałgorzataWoźniak, Bożena Cukrowska, Aldona Wierzbicka, Maria Goliszek, Piotr Socha, Wojciech Janczyk, Dilek Dayanakli, Dieter Abendroth, Sabine Kramp, Kai Fechner, Thomas Scheper, Michael Mahler, Chelsea Bentow, Dimietrios Bogdanos, Dietmar Fuchs, Marek Woynarowski
The impairment of regulatory T cells (Tregs) is a characteristic feature of autoimmune hepatitis (AIH), and the degradation of tryptophan (Trp) to kynurenine (Kyn), by gamma interferon-induced indoleamine-2,3-dioxygenase-1 (IDO-1), is a central metabolomics check point in the differentiation of Tregs. For this reason, we investigate whether or not Kyn and IDO activity is potentially useful biomarkers in pediatric AIH.Between January 2016 and January 2017, children of AIH type-1 (AIH-1, n = 37), AIH type-2 with liver kidney microsome-1 autoantibodies (AIH-2-LKM-1, n = 8), and autoantibody-negative Wilsons Disease (WD, n = 8) and alpha-1 anti-trypsin deficiency (AATD, n = 10), were enrolled in a cross-sectional survey of Kyn and Trp levels and Kyn/Trp ratios (IDO activity) by HPLC, and neopterin levels by ELISA...
January 21, 2019: Immunologic Research
Jarek Wosik, Martha Suarez-Villagran, John H Miller, Rafik M Ghobrial, Malgorzata Kloc
In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies...
January 16, 2019: Immunologic Research
Mohanned Naif Alhussien, Ajay Kumar Dang
Neutrophils represent the first line of innate immunity and are the most prominent line of cellular defence against invading microorganisms. On stimulation, they can quickly move through the walls of veins and into the tissues of the body to immediately attack or monitor the foreign antigens. Neutrophils are highly versatile and sophisticated cells which are endowed with highly sensitive receptor-based perception systems. They were traditionally classified as short-lived phagocytes actively involved during infection and inflammation, but recently, it has been seen that neutrophils are capable of detecting the presence of sperms during insemination as well as an implanting embryo in the female reproductive tract...
January 14, 2019: Immunologic Research
Khalaf Kridin, Rimma Laufer-Britva, Mouhammad Kridin, Doron Comaneshter, Erez Batat, Arnon D Cohen
The coexistence of pemphigus and systemic lupus erythematosus (SLE) had been reported anecdotally. Anti-desmoglein (Dsg)1 and anti-Dsg3 antibodies were detected concomitantly with antinuclear autoantibodies among blood donors. The aim of the current study was to study the association between pemphigus and SLE in Israeli patients and to synthesize existing data on this association in the current literature. The current study included two sections. Initially, a cross-sectional study was performed to compare pemphigus patients with age-, sex-, and ethnicity-matched control subjects regarding the prevalence of SLE using a real-life large-scale computerized database...
January 14, 2019: Immunologic Research
Vladimir Nazarov, Gleb Makshakov, Ivan Kalinin, Sergey Lapin, Elena Surkova, Liya Mikhailova, Boris Gilburd, Alexander Skoromets, Evgeniy Evdoshenko
Recent studies showed that B cells play a major role in the pathogenesis of neurodegeneration in multiple sclerosis (MS). In this study, we aimed to determine the possible link between immunoglobulin free light chains (FLC) and brain atrophy in patients with MS. Ninety-two patients (32 males and 60 females) with MS were included. Kappa and lambda FLC concentrations in serum and cerebrospinal fluid (CSF) samples of MS patients were measured using ELISA assay. FLC quotients (Q-k and Q-λ, respectively) were calculated...
January 11, 2019: Immunologic Research
J Asín, M Pérez, P Pinczowski, M Gimeno, L Luján
The use of vaccines has proven to be very effective in controlling and eradicating infectious diseases, both in veterinary and human medicine; however, vaccines can be also the source of an array of problems caused by procedures such as overimmunization. Bluetongue, an orbiviral disease that affects ruminants, is best controlled by the use of inactivated vaccines. During the last years of the past decade, these vaccines were applied all over Europe to control the spreading of the disease, a goal that was accomplished; however, at the same time, several adverse effects related to the vaccination were reported...
January 10, 2019: Immunologic Research
Poupak Fallahi, Silvia Martina Ferrari, Simona Piaggi, Michaela Luconi, Giulia Cantini, Stefania Gelmini, Giusy Elia, Ilaria Ruffilli, Alessandro Antonelli
Our study demonstrates that (C-X-C motif) ligand 9 and 11 (CXCL9, CXCL11) chemokines were absent basally in non-neoplastic thyroid (TFC) and papillary thyroid carcinoma (PTC) cells. Interferon (IFN)γ induced the chemokine secretion in TFC and PTC, while tumor necrosis factor (TNF)α induced it only in PTC. IFNγ+TNFα induced a synergistic chemokines release in PTC, and at a lower level in TFC. Peroxisome proliferator-activated receptor (PPAR)γ agonists suppressed dose-dependently IFNγ+TNFα-induced chemokine release in TFC, while stimulated it in PTC...
January 8, 2019: Immunologic Research
Huijuan Wang, Shuhong Zhou, Jiahong Zhang, Shangwen Lei, Jing Zhou
Recently, the roles of toll-like receptor (TLR) polymorphisms in inflammatory bowel disease (IBD) were intensively explored, with conflicting results. Therefore, we performed this study to better assess the relationship between TLR polymorphisms and the risk of IBD. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate associations between TLR polymorphisms and IBD. Significant associations with the risk of IBD were detected for the TLR1 rs5743611, TLR4 rs4986790, TLR4 rs4986791, and TLR6 rs5743810 polymorphisms in overall analyses...
January 8, 2019: Immunologic Research
A D Sabag, D Dias-Polak, J Bejar, H Sheffer, R Bergman, Zahava Vadasz
The presence of T regulatory cells (Tregs) is highly required in normal skin in order to maintain immune tolerance to commensal microbes and to prevent the development of immune-mediated inflammation. Psoriasis is a chronic inflammatory skin disease in which effector T cells, namely, Th17 and their relevant pro-inflammatory cytokines are increased in peripheral blood as well as in the inflamed skin. The status of Tregs in psoriatic skin is continuously studied. In this case, CD4 + CD25high T cells and other regulatory cytokines such as IL-35 are demonstrated to be significantly decreased...
January 7, 2019: Immunologic Research
Mara Mariconti, Ambra Vola, Tommaso Manciulli, Francesca Genco, Raffaella Lissandrin, Valeria Meroni, Mara Rosenzvit, Francesca Tamarozzi, Enrico Brunetti
The published article unfortunately contained mistake. After replacing the image from colored version to black and white, the Fig. 1 caption, unfortunately, was left unupdated.
December 27, 2018: Immunologic Research
C Barbati, M Vomero, T Colasanti, F Ceccarelli, M Marcosano, F Miranda, L Novelli, A Pecani, Carlo Perricone, F R Spinelli, S Truglia, F Conti, G Valesini, C Alessandri
Microparticles (MPs) are small membrane vesicles released by many cell types under physiological and pathological conditions. In the last years, these particles were considered as inert cell debris, but recently many studies have demonstrated they could have a role in intercellular communication. Increased levels of MPs have been reported in various pathological conditions including infections, malignancies, and autoimmune diseases, such as rheumatoid arthritis (RA). RA is an autoimmune systemic inflammatory disease characterized by chronic synovial inflammation, resulting in cartilage and bone damage with accelerated atherosclerosis increasing mortality...
December 21, 2018: Immunologic Research
Svetlana Blitshteyn, Louise Brinth, Jeanne E Hendrickson, Manuel Martinez-Lavin
In the recently published paper, "Autonomic dysfunction and HPV immunization: an overview", the last name of the lead author is listed incorrectly. The author's name is Svetlana Blitshteyn.
December 21, 2018: Immunologic Research
Jama Lambert, Soledad Mejia, Aristo Vojdani
Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability and setting the stage for neuroautoimmunity and neurodegeneration. Here, we review the role of aquaporins in plants and humans in maintaining a healthy organism and mechanisms by which dietary aquaporins may contribute to neurological disorders...
December 19, 2018: Immunologic Research
Manca Ogrič, Polona Žigon, David Drobne, Borut Štabuc, Snezna Sodin-Semrl, Saša Čučnik, Sonja Praprotnik
By monitoring serum concentrations of infliximab (IFX) and adalimumab (ADL) and levels of their antibodies in patients with inflammatory diseases, clinicians can adjust dose and increase safety and effectiveness of treatment. The aim was to develop and validate in-house enzyme-linked immunosorbent assays (ELISAs) for IFX and ADL, together with anti-IFX and anti-ADL ELISAs for routine detection and further analysis with acid dissociation of immune complexes. Furthermore, the objectives were to compare in-house assays with commercial ELISAs and reporter gene assays (RGAs) and to determine cross-reactivity between original Remicade®/Remsima™ and their antibodies...
December 19, 2018: Immunologic Research
Merav Lidar, Sewar Masarwa, Pnina Rotman, Or Carmi, Noa Rabinowicz, Yair Levy
To report the temporal association between a series of thromboembolic events and intravenous immunoglobulin infusion in patients with rheumatic diseases, and to review the literature on the subject. The clinical presentation, course, and outcome of thromboembolic events occurring post-immunoglobulin infusion in nine patients is described. A web-based literature review using the PubMed database from 1996 to 2017 was performed, searching for the keywords: thrombosis, thromboembolism, intravenous immunoglobulin, pulmonary embolism, deep vein thrombosis, cerebrovascular event, and acute myocardial infarction...
December 19, 2018: Immunologic Research
Yahel Segal, Miri Blank, Yehuda Shoenfeld
The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. In an attempt to develop a novel therapeutic small molecule for the treatment of autoimmune conditions, we have conjugated PC with tuftsin, a natural immunomodulatory tetrapeptide, to create TPC...
December 15, 2018: Immunologic Research
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