Lin-Lin Li, Zhong-Qiu Luan, Ying Tan, Hui Wang, Xiao-Juan Yu, Zhen Qu, Feng Yu, Min Chen
PURPOSE: Anti-complement factor H (CFH) autoantibodies could be detected in lupus and its significance remained to be elucidated. Herein, we aimed to explore the roles of anti-CFH autoantibodies based on pristane-induced lupus mice. METHODS: Twenty-four female Balb/c mice were randomly divided into four groups, with one group injected with pristane (pristane group), one group with pristane and then human CFH (hCFH) (pristane-CFH group) 3 times, and the other two as vertical controls, PBS group and PBS-CFH group...
June 16, 2023: Immunologic Research
Maria Infantino, Boaz Palterer, Maurizio Benucci, Valentina Grossi, Silvia Pancani, Mariangela Manfredi, Nicola Bizzaro
Rheumatoid factors (RFs) are useful for diagnosis and classification of rheumatoid arthritis (RA). Nephelometric and turbidimetric techniques, which detect total RF but do not reveal the antibody isotype, are common diagnostic methods in clinical routine. Given the recent development of isotype-specific immunoassays, the detection of IgG, IgM, and IgA RFs represents an interesting challenge. The aim of the study was to evaluate whether specific RF tests performed as a second step after traditional nephelometry could help differentiating RA from other RF-positive diseases...
June 15, 2023: Immunologic Research
Nikoo Saeedi, Narjes Sadat Farizani Gohari, Amir Ali Moodi Ghalibaf, Ali Dehghan, Mohammad Bagher Owlia
Following the global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the importance of investigation of the pathogenesis and immunological characteristics of COVID-19 became quite clear. Currently, there are reports indicating that COVID-19 is able to induce autoimmune responses. Abnormal immune reactions are a cornerstone in the pathogenicity of both conditions. Detection of autoantibodies in COVID-19 patients may suggest a link between COVID-19 and autoimmunity. In this study, we focused on the similarities and possible differences between COVID-19 and autoimmune disorders to explore the relationship between them...
June 14, 2023: Immunologic Research
Huimin Zhou, Qiugang Zhu, Zhenwei Mao, Min Li, Yue Zhang, Jun Yang, Jie Ma, Jie Tian, Shengjun Wang
Primary Sjögren's syndrome (pSS) is a progressive systemic autoimmune disease characterized by chronic inflammation of the exocrine glands, resulting in damage to the salivary and lacrimal glands. Our group and other researchers have reported that myeloid-derived suppressor cell-derived extracellular vesicles (MDSC-EVs) could attenuate the progression of autoimmune disease by impairing T-cell function. However, the effect of MDSC-EVs on B-cell function and the underlying mechanism remains largely unknown...
June 10, 2023: Immunologic Research
Wang Jiang, Mengling Li, Siyuan Peng, Tian Hu, Yan Long, Jiayi Zhang, Dan Peng, Yueming Shen
Ubiquitination (or ubiquitylation) and de-ubiquitination, which are both post-translational modifications (PTMs) of proteins, have become a research hotspot in recent years. Some ubiquitinated or de-ubiquitinated signaling proteins have been found to promote or suppress innate immunity through Toll-like receptor (TLR), RIG-like receptor (RIG-I-like receptor, RLR), NOD-like receptor (NLR), and the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS)-STING pathway. This article aimed to provide a review on the role of ubiquitination and de-ubiquitination, especially ubiquitin ligase enzymes and de-ubiquitinating enzymes, in the above four pathways...
June 9, 2023: Immunologic Research
Jizhong Guan, Yao Fan, Shuai Wang, Fangfang Zhou
Immune signal transduction is crucial to the body's defense against viral infection. Recognition of pathogen-associated molecular patterns by pattern recognition receptors (PRRs) activates the transcription of interferon regulators and nuclear factor-κB (NF-κB); this promotes the release of interferons and inflammatory factors. Efficient regulation of type I interferon and NF-κB signaling by members of the mitogen-activated protein (MAP) kinase kinase kinase (MAP3K) family plays an important role in antiviral immunity...
June 7, 2023: Immunologic Research
Dariusz Kajdaniuk, Wanda Foltyn, Elżbieta Morawiec-Szymonik, Zenon Czuba, Ewa Szymonik, Beata Kos-Kudła, Bogdan Marek
The effects of specific cytokines produced by T cell subsets (such as Th1, Th2, and newly discovered Th17, Treg, Tfh, or Th22) are diverse, depending on interactions with other cytokines, distinct signaling pathways, phase of the disease, or etiological factor. The immunity equilibrium of the immune cells, such as the Th1/Th2, the Th17/Treg, and the Th17/Th1 balance is necessary for the maintenance of the immune homeostasis. If the balance of the T cells subsets is damaged, the autoimmune response becomes enhanced which leads to autoimmune diseases...
June 3, 2023: Immunologic Research
Angelo Ruggiero, Matteo Megna, Gabriella Fabbrocini, Sonia Sofia Ocampo-Garza
Nowadays, the biological equipment available for the treatment of moderate-to-severe psoriasis is plenty. Anti-interleukin-23 represents the latest class of biologic approved for the management of moderate-to-severe psoriasis. Their efficacy and safety have been assessed through two major sources: clinical trials (CTs) and real-world experiences data (RWE). Notably, the two sources differ from one another, but together, they complement information and current knowledge on both efficacy and safety of biological therapy...
June 2023: Immunologic Research
Erika Iervasi, Antonella Strangio, Luigi Greco, Renata Auricchio, Daniele Saverino
Celiac disease (CD) is an autoimmune disease with inflammatory characteristics, having a condition of chronic malabsorption, affecting approximately 1% of the population at any age. In recent years, a concrete correlation between eating disorders and CD has emerged. Hypothalamus plays a central role in determining eating behaviour, regulating appetite and, consequently, food intake. One hundred and ten sera from celiac patients (40 active and 70 following a gluten-free diet) were tested for the presence of autoantibodies against primate hypothalamic periventricular neurons by immunofluorescence and by a home-made ELISA assay...
May 23, 2023: Immunologic Research
Li Zhou, Hui Lian, Yue Yin, Yuan-Sheng Zheng, Yu-Xin Han, Gao-Qi Liu, Zhi-Yong Wang
Muscularis macrophages, as the most abundant immune cells in the intestinal muscularis externa, exhibit tissue protective phenotype in the steady state. Owing to tremendous advances in technology, we now know the fact that muscularis macrophages are a heterogeneous population of cells which could be divided into different functional subsets depending on their anatomic niches. There is emerging evidence showing that these subsets, through molecular interactions with their neighbours, take part in a wide range of physiological and pathophysiological processes in the gut...
May 23, 2023: Immunologic Research
Iyengar Vaishnavi Venkatachari, Akshaya Chougule, Vijaya Gowri, Prasad Taur, Minnie Bodhanwala, Shakuntala Prabhu, Manisha Madkaikar, Mukesh Desai
To estimate the prevalence of monogenic inborn errors of immunity in patients with autoimmune diseases (AID), the study included 56 subjects (male:female ratio: 1.07) with mean age of onset of autoimmunity 7 years (4 months-46 years). 21/56 had polyautoimmunity. 5/56 patients met the JMF criteria for PID. The different AID referred were hematological (42%) > gastrointestinal (GI) (16%) > skin (14%) > endocrine (10%) > rheumatological (8%) > renal (6%) > neurological (2%). 36/56 reported recurrent infections...
May 18, 2023: Immunologic Research
Laura Martinez-Martinez, Juan Irure-Ventura, Aurora Jurado, Garbiñe Roy, Marco Antonio Montes, Yvelise Barrios, Beatriz Rodríguez-Bayona, Esther Vergara, Álvaro Prada, Ricardo Rojo, María Luisa Vargas
Antinuclear antibodies (ANA) are the most widely used immunological test for the diagnosis of autoimmune diseases. Despite the recommendations of experts, there is some variability in performing and interpreting this test in routine practice. In this context, the Spanish Group on Autoimmune Diseases (GEAI) of the Spanish Society of Immunology (SEI) conducted a national survey of 50 autoimmunity laboratories. Here we report the survey results on ANA testing, detection of related antigens, and our recommendations...
May 17, 2023: Immunologic Research
Cecilia Zivelonghi, Alessandro Dinoto, Sarosh R Irani, Andrew McKeon, Andrea Pilotto, Alessandro Padovani, Stefano Masciocchi, Eugenio Magni, Chiara R Mancinelli, Ruggero Capra, Giorgia T Maniscalco, Irene Volonghi, Ava Easton, Daniela Alberti, Gianluigi Zanusso, Salvatore Monaco, Gian Luca Salvagno, Giuseppe Lippi, Sergio Ferrari, Sara Mariotto
It is well established that neurological and non-neurological autoimmune disorders can be triggered by viral infections. It remains unclear whether SARS-CoV-2 infection induces similar conditions and whether they show a distinctive phenotype. We retrospectively identified patients with acute inflammatory CNS conditions referred to our laboratory for antibody testing during the pandemic (March 1 to August 31, 2020). We screened SARS-COV-2 IgA/IgG in all sera by ELISA and confirmed the positivity with additional assays...
May 12, 2023: Immunologic Research
Karin Warshavsky, Tal Zeeli, Ori Mekiten, Eli Sprecher, Barbara G Silverman, Aviv Barzilai, Sharon Baum
Pemphigus vulgaris (PV) is a rare autoimmune intraepidermal bullous disease. PV has a major effect on morbidity as well as quality of life. There is sparse literature regarding the association between pemphigus vulgaris (PV) and comorbid malignancies. In this study we aimed to assess the risk of malignancy in a cohort of patients with PV and characterize PV-associated malignancies. Data were collected from two tertiary referral centers between the years 2008 and 2019 and compared with the national cancer registry...
May 4, 2023: Immunologic Research
Edoardo Conticini, Miriana d'Alessandro, Paolo Cameli, Laura Bergantini, Elena Pordon, Lucia Cassai, Luca Cantarini, Elena Bargagli, Bruno Frediani, Brunetta Porcelli
The presence of interstitial lung disease (ILD) is a common and fearsome feature of idiopathic inflammatory myopathies (IIM). Such patients show radiological pattern of non-specific interstitial pneumonia (NSIP). The present study aimed to assess the prevalence of myositis-specific and myositis-associated antibodies (MSA and MAA) in a cohort of patients with a previous diagnosis of NSIP and no sign or symptom of IIM. Secondly, it will be assessed whether patients displaying MSA and/or MAA positivity have a worse or a better outcome than idiopathic NSIP...
May 3, 2023: Immunologic Research
Sílvia Torrents, Andrés Escudero Del Moral, Margarita Codinach, Luciano Rodríguez, Sergi Querol, Joaquim Vives
Multipotent mesenchymal stromal cells (MSC) offer new therapeutic opportunities based on their ability to modulate an imbalanced immune system. Immunomodulatory potency is typically demonstrated in vitro by measuring the presence of surrogate markers (i.e., indoleamine-2,3-dioxygenase, IDO; tumor necrosis factor receptor type 1, TNFR1) and/or functional assays in co-cultures (i.e., inhibition of lymphoproliferation, polarization of macrophages). However, the biological variability of reagents used in the latter type of assays leads to unreliable and difficult to reproduce data therefore making cross-comparison between batches difficult, both at the intra- and inter-laboratory levels...
April 29, 2023: Immunologic Research
Woorim Kim, Ha Rim Yeon, Jun Hyeob Kim, Joo Hee Kim, Ji Hyoun Kim, Hyoun-Ah Kim, Ju-Yang Jung, Jinhyun Kim, In Ah Choi, Kyung Eun Lee
Rheumatoid arthritis (RA) is a severe chronic inflammatory condition that affects joint synovium. Suppressor/enhancer of lin-12-like (SEL1L)-Synoviolin 1 (SYVN1)-mediated endoplasmic reticulum-associated degradation (ERAD) is highly associated with RA development. Although targeting SEL1L-SYVN1-mediated ERAD can be beneficial, studies that evaluate the association between polymorphisms in their genes and remission from the disease in RA patients taking tumor necrosis factor (TNF)-α inhibitors have yet to be carried out...
April 29, 2023: Immunologic Research
Kevin Roe
No abstract text is available yet for this article.
April 27, 2023: Immunologic Research
Shima Izadi, Sayed Reza Najfizadeh, Ahmad Nejati, Majid TeimooriRad, Shohreh Shahmahmoodi, Frough Golsaz Shirazi, Fazel Shokri, Sayed Mahdi Marashi
SLE is a multisystem autoimmune disease characterized by multiple immunological abnormalities including production of autoantibodies. While the etiology of SLE is largely unknown, it is generally accepted that both genetic and environmental factors contribute to disease risk and immune dysregulation. Production of IFN-α is important for protecting the host against infections; however, over stimulation of innate immune pathways can induce autoimmune disease. Environmental factors, particularly Epstein-Barr virus (EBV), have been proposed to play an important role in SLE disease...
April 25, 2023: Immunologic Research
Jia-Ying Lin, Bing-Xue Bai
No abstract text is available yet for this article.
April 20, 2023: Immunologic Research
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