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Movement Disorders: Official Journal of the Movement Disorder Society

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https://read.qxmd.com/read/31107979/endurance-exercise-reduces-cortisol-in-parkinson-s-disease-with-mild-cognitive-impairment
#1
LETTER
Nina Smyth, Elizabeth Skender, Fabian J David, Miranda J Munoz, Giamila Fantuzzi, Angela Clow, Jennifer G Goldman, Daniel M Corcos
No abstract text is available yet for this article.
May 20, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31091353/environment-lifestyle-and-parkinson-s-disease-implications-for-prevention-in-the-next-decade
#2
REVIEW
Connie Marras, Colleen G Canning, Samuel M Goldman
There is evidence from observational studies for a role of a number of environmental exposures and lifestyle habits in modulating the risk for Parkinson's disease. Environmental and lifestyle associations, if causal, represent opportunities for Parkinson's disease prevention or disease modification at individual and population levels. In the past decade, additional evidence has been published that improves causal inference and/or enhances our understanding of the complexity of these associations. A number of gene-environment interactions have been elucidated, and our understanding of the roles of physical activity, pesticide and other chemical exposures, dietary habits, emotional stress, head injury, and smoking has been refined...
May 15, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31091347/voxel-based-quantitative-susceptibility-mapping-in-parkinson-s-disease-with-mild-cognitive-impairment
#3
Yuto Uchida, Hirohito Kan, Keita Sakurai, Nobuyuki Arai, Daisuke Kato, Shoji Kawashima, Yoshino Ueki, Noriyuki Matsukawa
OBJECTIVE: Brain iron accumulation has been proposed as one of the pathomechanisms in Parkinson's disease (PD). This study aimed to examine the whole-brain pattern of iron accumulation associated with cognitive impairment in patients with PD using voxel-based quantitative susceptibility mapping analysis. METHODS: We enrolled 24 patients with PD and mild cognitive impairment, 22 patients with PD and normal cognition, and 20 age-matched healthy controls in this cross-sectional study...
May 15, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31083822/l-dopa-free-learned-dyskinetic-behavior-in-a-parkinson-s-primate-model
#4
LETTER
Qin Li, Pierre-Olivier Fernagut, Erwan Bezard
No abstract text is available yet for this article.
May 13, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31077447/engrailed-1-induces-long-lasting-behavior-benefit-in-an-experimental-parkinson-primate-model
#5
LETTER
Nitza Thomasson, Elsa Pioli, Claire Friedel, Arnaud Monseur, Jérémie Lavaur, Kenneth L Moya, Erwan Bezard, Anne Bousseau, Alain Prochiantz
No abstract text is available yet for this article.
May 11, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31077443/functional-movement-disorders-is-the-crisis-resolved
#6
Mark Hallett
No abstract text is available yet for this article.
May 11, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31077436/structural-connectivity-based-topography-of-the-human-globus-pallidus-implications-for-therapeutic-targeting-in-movement-disorders
#7
Alberto Cacciola, Demetrio Milardi, Salvatore Bertino, Gianpaolo Antonio Basile, Alessandro Calamuneri, Gaetana Chillemi, Giuseppina Rizzo, Giuseppe Anastasi, Angelo Quartarone
BACKGROUND: Understanding the topographical organization of the cortico-basal ganglia circuitry is of pivotal importance because of the spreading of techniques such as DBS and, more recently, MR-guided focused ultrasound for the treatment of movement disorders. A growing body of evidence has described both direct cortico- and dento-pallidal connections, although the topographical organization in vivo of these pathways in the human brain has never been reported. OBJECTIVE: To investigate the topographical organization of cortico- and dento-pallidal pathways by means of diffusion MRI tractography and connectivity based parcellation...
May 11, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31077434/early-onset-pathologically-proven-multiple-system-atrophy-with-lrrk2-g2019s-mutation
#8
LETTER
Giulietta Maria Riboldi, Jose-Alberto Palma, Etty Cortes, Megan A Iida, Tamjeed Sikder, Brooklyn Henderson, Towfique Raj, Ruth H Walker, John F Crary, Horacio Kaufmann, Steven Frucht
No abstract text is available yet for this article.
May 11, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31059154/genome-wide-survey-of-copy-number-variants-finds-mapt-duplications-in-progressive-supranuclear-palsy
#9
Zhongbo Chen, Jason A Chen, Aleksey Shatunov, Ashley R Jones, Stephanie N Kravitz, Alden Y Huang, Lauren Lawrence, Jennifer K Lowe, Cathryn M Lewis, Christine A M Payan, Wolfgang Lieb, Andre Franke, Panagiotis Deloukas, Philippe Amouyel, Christophe Tzourio, Jean-François Dartigues, Albert Ludolph, Gilbert Bensimon, P Nigel Leigh, Jeff M Bronstein, Giovanni Coppola, Daniel H Geschwind, Ammar Al-Chalabi
BACKGROUND: Progressive supranuclear palsy is a neurodegenerative tauopathy manifesting clinically as a progressive akinetic-rigid syndrome. In this study, we sought to identify genetic variants influencing PSP susceptibility through a genome-wide association analysis of a cohort of well-characterized patients who had participated in the Neuroprotection and Natural History in Parkinson Plus Syndromes and Blood Brain Barrier in Parkinson Plus Syndromes studies. METHODS: We genotyped single-nucleotide polymorphisms in 283 PSP cases from the United Kingdom, Germany, and France and compared these with genotypes from 4472 controls...
May 6, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31046191/clinical-and-methodological-challenges-for-assessing-freezing-of-gait-future-perspectives
#10
REVIEW
Martina Mancini, Bastiaan R Bloem, Fay B Horak, Simon J G Lewis, Alice Nieuwboer, Jorik Nonnekes
Freezing of gait, defined as sudden and usually brief episodes of inability to produce effective stepping, often results in falls and is both disabling and common in parkinsonism. In this narrative review, sprung from the 2nd International Workshop on freezing of gait in Leuven, we summarize the latest insights into clinical and methodological challenges for assessing freezing of gait. We also highlight the role of emerging wearable technology to improve the management of this debilitating symptom. © 2019 International Parkinson and Movement Disorder Society...
May 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31046188/prepulse-inhibition-of-the-blink-reflex-is-abnormal-in-functional-movement-disorders
#11
Zuzana Hanzlíková, Markus Kofler, Matěj Slovák, Gabriela Věchetová, Anna Fečíková, David Kemlink, Tomáš Sieger, Evžen Růžička, Josep Valls-Solé, Mark J Edwards, Tereza Serranová
BACKGROUND: Patients with functional movement disorders also typically have functional somatic symptoms, including pain, fatigue, and sensory disturbance. A potentially unifying mechanism for such symptoms is a failure in processing of sensory inputs. Prepulse inhibition is a neurophysiological method that allows for the study of preconscious somatosensory processing. OBJECTIVE: The objective of this study was to assess prepulse inhibition in patients with functional movement disorders and healthy control subjects...
May 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31046186/mds-evidence-based-review-of-treatments-for-essential-tremor
#12
REVIEW
Joaquim J Ferreira, Tiago A Mestre, Kelly E Lyons, Julián Benito-León, Eng-King Tan, Giovanni Abbruzzese, Mark Hallett, Dietrich Haubenberger, Rodger Elble, Günther Deuschl
BACKGROUND: Essential tremor is one of the most prevalent movement disorders. Many treatments for essential tremor have been reported in clinical practice, but it is uncertain which options have the most robust evidence. The International Parkinson and Movement Disorder Society commissioned a task force on tremor to review clinical studies of treatments for essential tremor. OBJECTIVES: To conduct an evidence-based review of current pharmacological and surgical treatments for essential tremor, using standardized criteria defined a priori by the International Parkinson and Movement Disorder Society...
May 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31034682/the-use-of-transcranial-magnetic-stimulation-as-a-treatment-for-movement-disorders-a-critical-review
#13
REVIEW
Anna Latorre, Lorenzo Rocchi, Alfredo Berardelli, Kailash P Bhatia, John C Rothwell
BACKGROUND: Transcranial magnetic stimulation is a safe and painless non-invasive brain stimulation technique that has been largely used in the past 30 years to explore cortical function in healthy participants and, inter alia, the pathophysiology of movement disorders. During the years, its use has evolved from primarily research purposes to treatment of a large variety of neurological and psychiatric diseases. In this article, we illustrate the basic principles on which the therapeutic use of transcranial magnetic stimulation is based and review the clinical trials that have been performed in patients with movement disorders...
April 29, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31034681/myoclonus-dystonia-caused-by-gnb1-mutation-responsive-to-deep-brain-stimulation
#14
LETTER
Hannah F Jones, Hugo Morales-Briceño, Katy Barwick, Jennifer Lewis, Alba Sanchis-Juan, F Lucy Raymond, Kirsty Stewart, Mary-Clare Waugh, Neil Mahant, Manju A Kurian, Russell C Dale, Shekeeb S Mohammad
No abstract text is available yet for this article.
April 29, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31034671/a-critique-of-the-second-consensus-criteria-for-multiple-system-atrophy
#15
Iva Stankovic, Niall Quinn, Luca Vignatelli, Angelo Antonini, Daniela Berg, Elizabeth Coon, Pietro Cortelli, Alessandra Fanciulli, Joaquim J Ferreira, Roy Freeman, Glenda Halliday, Günter U Höglinger, Valeria Iodice, Horacio Kaufmann, Thomas Klockgether, Vladimir Kostic, Florian Krismer, Anthony Lang, Johannes Levin, Phillip Low, Christopher Mathias, Wassillios G Meissner, Lucy Norcliffe Kaufmann, Jose-Alberto Palma, Jalesh N Panicker, Maria Teresa Pellecchia, Ryuji Sakakibara, Jeremy Schmahmann, Sonja W Scholz, Wolfgang Singer, Maria Stamelou, Eduardo Tolosa, Shoji Tsuji, Klaus Seppi, Werner Poewe, Gregor K Wenning
No abstract text is available yet for this article.
April 29, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31021467/chronic-renal-dysfunction-proteinuria-and-risk-of-parkinson-s-disease-in-the-elderly
#16
Ga Eun Nam, Nan Hee Kim, Kyungdo Han, Kyung Mook Choi, Hye Soo Chung, Jin Wook Kim, Byoungduck Han, Sung Jung Cho, Seung Jin Jung, Ji Hee Yu, Yong Gyu Park, Seon Mee Kim
BACKGROUND: The roles of chronic kidney disease and proteinuria in the development of Parkinson's disease have not been widely studied. The objective of this study was to examine the associations of chronic renal dysfunction and proteinuria with the risk of PD in older adults using cohort data of the whole South Korean population. METHODS: We included 3,580,435 individuals aged ≥65 years who had undergone health checkups provided by the National Health Insurance Service of South Korea between 2009 and 2012 and were followed until 2015...
April 25, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31002755/genetic-silencing-of-striatal-cav1-3-prevents-and-ameliorates-levodopa-dyskinesia
#17
Kathy Steece-Collier, Jennifer A Stancati, Nicholas J Collier, Ivette M Sandoval, Natosha M Mercado, Caryl E Sortwell, Timothy J Collier, Fredric P Manfredsson
BACKGROUND: Levodopa-induced dyskinesias are an often debilitating side effect of levodopa therapy in Parkinson's disease. Although up to 90% of individuals with PD develop this side effect, uniformly effective and well-tolerated antidyskinetic treatment remains a significant unmet need. The pathognomonic loss of striatal dopamine in PD results in dysregulation and disinhibition of striatal CaV1.3 calcium channels, leading to synaptopathology that appears to be involved in levodopa-induced dyskinesias...
April 19, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31002748/dopamine-drives-binge-like-consumption-of-a-palatable-food-in-experimental-parkinsonism
#18
Désirée Mineo, Fabrizio Cacace, Maria Mancini, Anna Vannelli, Federica Campanelli, Giuseppina Natale, Gioia Marino, Antonella Cardinale, Paolo Calabresi, Barbara Picconi, Veronica Ghiglieri
BACKGROUND: Prolonged dopaminergic replacement therapy in PD results in pulsatile dopamine receptors stimulation in both dorsal and ventral striatum causing wearing off, motor fluctuations, and nonmotor side effects such as behavioral addictions. Among impulse control disorders, binge eating can be easily modeled in laboratory animals. OBJECTIVES: We hypothesize that manipulation of dopamine levels in a 6-hydroxydopamine-lesioned rats, as a model of PD characterized by a different extent of dopamine denervation between dorsal and ventral striatum, would influence both synaptic plasticity of the nucleus accumbens and binge-like eating behavior...
April 19, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30990922/levodopa-is-the-best-symptomatic-therapy-for-pd-nothing-more-nothing-less
#19
C Warren Olanow
No abstract text is available yet for this article.
April 16, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30983023/should-there-be-less-emphasis-on-levodopa-induced-dyskinesia-in-parkinson-s-disease
#20
K Ray Chaudhuri, Peter Jenner, Angelo Antonini
No abstract text is available yet for this article.
April 14, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
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