journal
Journals Movement Disorders : Official ...

Movement Disorders : Official Journal of the Movement Disorder Society

https://read.qxmd.com/read/36959763/machine-learning-in-tremor-analysis-critique-and-directions
#1
REVIEW
Anwesan De, Kailash P Bhatia, Jens Volkmann, Robert Peach, Sebastian R Schreglmann
Tremor is the most frequent human movement disorder, and its diagnosis is based on clinical assessment. Yet finding the accurate clinical diagnosis is not always straightforward. Fine-tuning of clinical diagnostic criteria over the past few decades, as well as device-based qualitative analysis, has resulted in incremental improvements to diagnostic accuracy. Accelerometric assessments are commonplace, enabling clinicians to capture high-resolution oscillatory properties of tremor, which recently have been the focus of various machine-learning (ML) studies...
March 23, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36959736/lack-of-causal-associations-of-inflammatory-bowel-disease-with-parkinson-s-disease-and-other-neurodegenerative-disorders
#2
JOURNAL ARTICLE
Ruijie Zeng, Jinghua Wang, Chunwen Zheng, Rui Jiang, Shuangshuang Tong, Huihuan Wu, Zewei Zhuo, Qi Yang, Felix W Leung, Weihong Sha, Hao Chen
BACKGROUND: Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's disease (PD). OBJECTIVE: To evaluate the causal associations of IBD with PD and other selected neurodegenerative disorders using updated data. METHODS: Bidirectional two-sample Mendelian randomization studies using genome-wide association studies summary statistics of IBD and PD. RESULTS: We found a lack of evidence for the causal association of IBD on PD (odds ratio [OR], 1...
March 23, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36947685/limb-preference-changes-after-focused-ultrasound-thalamotomy-for-tremor
#3
JOURNAL ARTICLE
Catherine A Swytink-Binnema, Conrad P Rockel, Davide Martino, Sean P Dukelow, G Bruce Pike, Zelma H T Kiss
BACKGROUND: Magnetic resonance-guided focused-ultrasound (MRgFUS) thalamotomy is an effective treatment for essential and other tremors. It targets the ventrointermedius (Vim) nucleus, which is the thalamic relay in a proprioceptive pathway, and contains kinesthetic cells. Although MRgFUS thalamotomy reduces some risks associated with more invasive surgeries, it still has side effects, such as balance and gait disturbances; these may be caused by the lesion impacting proprioception. OBJECTIVES: Our aim was to quantitatively measure the effects of MRgFUS on proprioception and limb use in essential tremor patients...
March 22, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36947674/monitoring-substantia-nigra-degeneration-using-free-water-imaging-across-prodromal-and-clinical-parkinson-s-disease
#4
JOURNAL ARTICLE
Gaiyan Zhou, Jingru Ren, Danyan Rong, Hao Zhou, Houxu Ning, Hui Wang, Chenxi Pan, Yajie Wang, Ronggui Zhang, Zhiying Guo, Peiyu Huang, Weiguo Liu
BACKGROUND: Substantia nigra (SN) free water has been suggested as a good surrogate marker in Parkinson's disease (PD). However, its usefulness for diagnosing prodromal PD (pPD) and monitoring disease progression warrants further validation. OBJECTIVE: The aim was to investigate SN free water values across prodromal and clinical stages of PD. METHODS: Four groups were enrolled in this study: 48 healthy controls (HC), 43 pPD patients, 50 de novo PD (dnPD) patients, and 49 medicated PD (mPD) patients...
March 22, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36945748/target-specific-strategies-to-modify-the-course-of-parkinson-s-is-iron-chelation-safe
#5
JOURNAL ARTICLE
Tiago A Mestre, Michael G Schlossmacher
No abstract text is available yet for this article.
March 21, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36938854/long-term-intake-of-folate-vitamin-b6-and-vitamin-b12-and-the-incidence-of-parkinson-s-disease-in-a-sample-of-u-s-women-and-men
#6
JOURNAL ARTICLE
Mario H Flores-Torres, Chadwick W Christine, Kjetil Bjornevik, Samantha A Molsberry, Albert Y Hung, Brian C Healy, Deborah Blacker, Michael A Schwarzschild, Alberto Ascherio
BACKGROUND: Folate and vitamins B6 and B12 have been proposed as protective against the development of Parkinson's disease (PD). Two prior longitudinal studies were inconclusive. OBJECTIVE: The aim was to examine the association of long-term intake of folate, vitamin B6, and vitamin B12 with the incidence of PD. METHODS: The study population comprised 80,965 women (Nurses' Health Study, 1984-2016) and 48,837 men (Health Professionals Follow-up Study, 1986-2016) followed prospectively for the development of PD...
March 20, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36928898/a-novel-metric-for-predicting-severity-of-disease-features-in-friedreich-s-ataxia
#7
JOURNAL ARTICLE
Layne N Rodden, Christian Rummey, Sudha Kessler, Robert B Wilson, David R Lynch
BACKGROUND: Friedreich's ataxia (FRDA), most commonly caused by a GAA triplet repeat (GAA-TR) expansion in intron 1 of the FXN gene, is characterized by deficiency of frataxin protein and clinical features such as progressive ataxia, dysarthria, impaired proprioception and vibration, abolished deep tendon reflexes, Babinski sign, and vision loss in association with non-neurological features such as skeletal anomalies, hearing loss, cardiomyopathy, and diabetes. Pathogenic GAA-TRs range in size from 60 to 1500 triplets and negatively correlate with age of onset...
March 16, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36916660/a-biomarker-study-in-patients-with-gba1-parkinson-s-disease-and-healthy-controls
#8
JOURNAL ARTICLE
Jonas M den Heijer, Valerie C Cullen, Diana R Pereira, Yalcin Yavuz, Marieke L de Kam, Hendrika W Grievink, Matthijs Moerland, Nancy Leymarie, Kshitij Khatri, Imelda Sollomoni, Leslie Spitalny, Lindsay Dungeon, Dana C Hilt, Craig Justman, Peter Lansbury, Geert Jan Groeneveld
BACKGROUND: Molecules related to glucocerebrosidase (GCase) are potential biomarkers for development of compounds targeting GBA1-associated Parkinson's disease (GBA-PD). OBJECTIVES: Assessing variability of various glycosphingolipids (GSLs) in plasma, peripheral blood mononuclear cells (PBMCs), and cerebrospinal fluid (CSF) across GBA-PD, idiopathic PD (iPD), and healthy volunteers (HVs). METHODS: Data from five studies were combined. Variability was assessed of glucosylceramide (various isoforms), lactosylceramide (various isoforms), glucosylsphingosine, galactosylsphingosine, GCase activity (using fluorescent 4-methylumbeliferryl-β-glucoside), and GCase protein (using enzyme-linked immunosorbent assay) in plasma, PBMCs, and CSF if available, in GBA-PD, iPD, and HVs...
March 14, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36912400/peripheral-inflammation-is-associated-with-dopaminergic-degeneration-in-parkinson-s-disease
#9
JOURNAL ARTICLE
Laura Muñoz-Delgado, Miguel Ángel Labrador-Espinosa, Daniel Macías-García, Silvia Jesús, Belén Benítez Zamora, Paula Fernández-Rodríguez, Astrid D Adarmes-Gómez, María Isabel Reina Castillo, Sandra Castro-Labrador, Jesús Silva-Rodríguez, Fátima Carrillo, David García Solís, Michel J Grothe, Pablo Mir
BACKGROUND: Peripheral inflammatory immune responses are suggested to play a major role in dopaminergic degeneration in Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR) is a well-established biomarker of systemic inflammation in PD. Degeneration of the nigrostriatal dopaminergic system can be assessed in vivo using [123 I]FP-CIT single photon emission computed tomography imaging of striatal dopamine transporter (DAT) density. OBJECTIVES: To assess the relationship between the peripheral immune profile (NLR, lymphocytes, and neutrophils) and striatal DAT density in patients with PD...
March 13, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36905188/synaptic-density-and-glucose-consumption-in-patients-with-lewy-body-diseases-an-11-c-ucb-j-and-18-f-fdg-pet-study
#10
JOURNAL ARTICLE
Katrine B Andersen, Allan K Hansen, Anna Christina Schacht, Jacob Horsager, Hanne Gottrup, Henriette Klit, Erik H Danielsen, Kathleen L Poston, Nicola Pavese, David J Brooks, Per Borghammer
BACKGROUND: Patients with Lewy body diseases exhibit variable degrees of cortical and subcortical hypometabolism. However, the underlying causes behind this progressive hypometabolism remain unresolved. Generalized synaptic degeneration may be one key contributor. OBJECTIVE: The objective of this study was to investigate whether local cortical synaptic loss is proportionally linked to the magnitude of hypometabolism in Lewy body disease. METHOD: Using in vivo positron emission tomography (PET) we investigated cerebral glucose metabolism and quantified the density of cerebral synapses, as measured with [18 F]fluorodeoxyglucose ([18 F]FDG) PET and [11 C]UCB-J, respectively...
March 11, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36881930/insights-into-neurodegeneration-in-parkinson-s-disease-from-single-cell-and-spatial-genomics
#11
JOURNAL ARTICLE
Tushar Kamath, Evan Z Macosko
Parkinson's disease (PD) is pathologically defined by the death of dopaminergic (DA) neurons within the pars compacta of the substantia nigra. To date, the cause of this multifaceted disease remains largely unclear, which may contribute in part to a current lack of disease-modifying therapies. Recent advances in single-cell and spatial genomic profiling tools have provided powerful new ways to measure cellular state changes in brain diseases. Here, we describe how these tools have offered insight into these complex disorders and highlight a recently performed comprehensive study of DA neuron susceptibility in PD...
March 7, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36876974/paraquat-parkinson-s-disease-and-agnotology
#12
JOURNAL ARTICLE
E Ray Dorsey, Amit Ray
No abstract text is available yet for this article.
March 6, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36869417/polygenic-parkinson-s-disease-genetic-risk-score-as-risk-modifier-of-parkinsonism-in-gaucher-disease
#13
JOURNAL ARTICLE
Cornelis Blauwendraat, Nahid Tayebi, Elizabeth Geena Woo, Grisel Lopez, Luca Fierro, Marco Toffoli, Naomi Limbachiya, Derralynn Hughes, Vanessa Pitz, Dhairya Patel, Dan Vitale, Mathew J Koretsky, Dena Hernandez, Raquel Real, Roy N Alcalay, Mike A Nalls, Huw R Morris, Anthony H V Schapira, Manisha Balwani, Ellen Sidransky
BACKGROUND: Biallelic pathogenic variants in GBA1 are the cause of Gaucher disease (GD) type 1 (GD1), a lysosomal storage disorder resulting from deficient glucocerebrosidase. Heterozygous GBA1 variants are also a common genetic risk factor for Parkinson's disease (PD). GD manifests with considerable clinical heterogeneity and is also associated with an increased risk for PD. OBJECTIVE: The objective of this study was to investigate the contribution of PD risk variants to risk for PD in patients with GD1...
March 3, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36853618/brain-and-systemic-inflammation-in-de-novo-parkinson-s-disease
#14
JOURNAL ARTICLE
Talene A Yacoubian, Yu-Hua Dean Fang, Adam Gerstenecker, Amy Amara, Natividad Stover, Lauren Ruffrage, Christopher Collette, Richard Kennedy, Yue Zhang, Huixian Hong, Hongwei Qin, Jonathan McConathy, Etty N Benveniste, David G Standaert
OBJECTIVE: To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD). BACKGROUND: Evidence for a pathophysiologic role of inflammation in PD is growing. However, several key gaps remain as to the role of inflammation in PD, including the extent of immune activation at early stages, potential effects of PD treatments on inflammation and whether pro-inflammatory signals are associated with clinical features and/or predict more rapid progression...
February 28, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36853590/susceptibility-weighted-imaging-reveals-subcortical-iron-deposition-in-pla2g6-associated-neurodegeneration-the-double-cortex-sign
#15
LETTER
Benjamin Roeben, Lena Zeltner, Gisela E Hagberg, Klaus Scheffler, Ludger Schöls, Benjamin Bender
No abstract text is available yet for this article.
February 28, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36847357/redefining-bradykinesia
#16
JOURNAL ARTICLE
Matteo Bologna, Alberto J Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
No abstract text is available yet for this article.
February 27, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36847308/duodenal-alpha-synuclein-pathology-and-enteric-gliosis-in-advanced-parkinson-s-disease
#17
JOURNAL ARTICLE
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garrì, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G Kovacs, Angelo Antonini
BACKGROUND: The role of the gut-brain axis has been recently highlighted as a major contributor to Parkinson's disease (PD) physiopathology, with numerous studies investigating bidirectional transmission of pathological protein aggregates, such as α-synuclein (αSyn). However, the extent and the characteristics of pathology in the enteric nervous system have not been fully investigated. OBJECTIVE: We characterized αSyn alterations and glial responses in duodenum biopsies of patients with PD by employing topography-specific sampling and conformation-specific αSyn antibodies...
February 27, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36840442/long-duration-response-to-levodopa-motor-learning-and-neuroplasticity-in-early-parkinson-s-disease
#18
JOURNAL ARTICLE
Giorgia Sciacca, Giovanni Mostile, Ivano Disilvestro, Giulia Donzuso, Alessandra Nicoletti, Mario Zappia
BACKGROUND: Long-duration response (LDR) to levodopa and motor learning could be involved in changes in neuroplasticity of cortical excitability in Parkinson's disease (PD). P300, motor evoked potentials (MEPs), and Bereitschaftspotential (BP) are neurophysiological surrogate markers of neuroplasticity. OBJECTIVE: We aimed to define in PD the effects of LDR and motor learning on neurophysiological parameters involved in neuroplasticity. METHODS: Drug-naive PD patients underwent a 15-day treatment with levodopa/carbidopa 250/25 mg daily...
February 25, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36825772/effects-of-dihydropyridines-on-the-motor-and-cognitive-outcomes-of-patients-with-parkinson-s-disease
#19
JOURNAL ARTICLE
Jin Ho Jung, Han Kyu Na, Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Sang Jin Kim, Young H Sohn, Phil Hyu Lee
BACKGROUND: Dihydropyridines (DHPs) may have neuroprotective effects against Parkinson's disease (PD). OBJECTIVE: This study investigated the effects of DHPs on nigrostriatal dopaminergic denervation and longitudinal motor and cognitive outcomes in PD. METHODS: We classified 476 patients with drug-naive PD who had undergone dopamine transporter imaging into three groups. They were selected according to a prior diagnosis of hypertension and use of DHPs and were matched using propensity scores: patients without hypertension (HTN-; n = 50) and patients with hypertension treated without DHP (HTN+/DHP-; n = 50) or with DHP (HTN+/DHP+; n = 50)...
February 24, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/36811296/peripheral-inflammation-links-with-the-severity-of-clinical-phenotype-in-spinocerebellar-ataxia-2
#20
JOURNAL ARTICLE
Yaimeé Vázquez-Mojena, Yanetsy Rodríguez-Córdova, Yennis Dominguez-Barrios, Karen León-Arcia, David Miranda-Becerra, Yanetza Gonzalez-Zaldivar, Guillermo Guerra-Bustillos, Ulf Ziemann, Georg Auburger, Roberto Rodríguez-Labrada, María de Los Ángeles Robinson-Agramonte, Luis Velázquez-Pérez
BACKGROUND: The role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is unknown. OBJECTIVE: The objective of this study was to identify peripheral inflammation biomarkers and their relationship with the clinical and molecular features. METHODS: Blood cell count-derived inflammatory indices were measured in 39 SCA2 subjects and their matched controls. Clinical scores of ataxia, nonataxia, and cognitive dysfunction were assessed...
February 22, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
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