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Movement Disorders: Official Journal of the Movement Disorder Society

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https://read.qxmd.com/read/30983023/should-there-be-less-emphasis-on-levodopa-induced-dyskinesia-in-parkinson-s-disease
#1
K Ray Chaudhuri, Peter Jenner, Angelo Antonini
No abstract text is available yet for this article.
April 14, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30977934/-18-f-fluoroethoxybenzovesamicol-in-parkinson-s-disease-patients-quantification-of-a-novel-cholinergic-positron-emission-tomography-tracer
#2
LETTER
Sygrid van der Zee, David Vállez García, Philip H Elsinga, Antoon T M Willemsen, Hendrikus H Boersma, Marleen J J Gerritsen, Jacoba M Spikman, Teus van Laar
No abstract text is available yet for this article.
April 12, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30970153/will-genotype-drive-treatment-options
#3
Norbert Brüggemann, Christine Klein
Individual genetic variation can have a major impact on the clinical manifestation of a movement disorder and its response to treatment. Advances in gene discovery and increasing availability of diagnostic genetic testing have led to the identification of a growing number of patients with well-defined hereditary movement disorders. Establishing a genetic diagnosis may greatly impact patient counseling and shape therapeutic decisions. Further, assignment of a movement disorder to a specific genetic defect holds promise for the development of causal treatment approaches and individualized therapies, especially as the first gene-targeted approaches have recently entered clinical trials...
April 10, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30964957/lrp10-in-autosomal-dominant-parkinson-s-disease
#4
You Chen, Zhidong Cen, Xiaosheng Zheng, Qinqing Pan, Xinhui Chen, Lili Zhu, Si Chen, Hongwei Wu, Fei Xie, Haotian Wang, Dehao Yang, Lebo Wang, Baorong Zhang, Wei Luo
BACKGROUND: Recently, the LRP10 gene has been identified as a novel genetic cause in individuals affected by Parkinson's disease (PD), Parkinson's disease dementia, or dementia with Lewy bodies. OBJECTIVE: We investigated the involvement of LRP10 mutations in Chinese patients with familial PD and reviewed previous studies of LRP10 mutations in patients with PD. METHODS: A mutation analysis of the LRP10 gene was performed in a cohort of 205 unrelated Chinese patients with familial PD...
April 9, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30964956/a-novel-gnal-mutation-in-familial-dystonia-presenting-with-childhood-tremor-and-myoclonus
#5
LETTER
Aisling R Geoghegan, Mariam Al Hussona, Nick J Beauchamp, Michael Hutchinson, M B Sean O'Riordan, Tim Lynch, David Webb
No abstract text is available yet for this article.
April 9, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30964949/what-does-migration-between-the-faroe-islands-and-denmark-tell-us-about-the-etiology-of-parkinson-s-disease
#6
LETTER
Maria Skaalum Petersen, Søren Nymand Lophaven, Elsebeth Lynge, Pál Weihe
No abstract text is available yet for this article.
April 9, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30964942/parkinson-s-disease-how-do-highly-toxic-%C3%AE-synuclein-par-aggregates-mediate-neuronal-cell-death
#7
Sarah Graff, Sonja Petkovic
No abstract text is available yet for this article.
April 9, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30958572/neurorehabilitation-improves-the-motor-features-in-prodromal-sca2-a-randomized-controlled-trial
#8
Luis Velázquez-Pérez, Julio C Rodríguez-Diaz, Roberto Rodríguez-Labrada, Jacqueline Medrano-Montero, Annety B Aguilera Cruz, Lorenzo Reynaldo-Cejas, Mariela Góngora-Marrero, Annelié Estupiñán-Rodríguez, Yaimeé Vázquez-Mojena, Reidenis Torres-Vega
BACKGROUND: The search for early interventions is a novel approach in spinocerebellar ataxias, but there are few studies supporting this notion. This article aimed to assess the efficacy of neurorehabilitation treatment in prodromal spinocerebellar ataxia type 2. METHODS: Thirty spinocerebellar ataxia type 2 preclinical carriers were enrolled in a randomized, controlled trial using neurorehabilitation. The intervention in the treated group was 4 hours per day, 5 days per week for 12 weeks, emphasizing static balance, gait, and limb coordination...
April 8, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30958571/does-levodopa-have-a-disease-modifying-effect-in-parkinson-s-disease-evidence-from-a-delayed-start-trial
#9
Gaetano Barbagallo, Aldo Quattrone
No abstract text is available yet for this article.
April 8, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30957308/parkinson-s-disease-age-at-onset-genome-wide-association-study-defining-heritability-genetic-loci-and-%C3%AE-synuclein-mechanisms
#10
Cornelis Blauwendraat, Karl Heilbron, Costanza L Vallerga, Sara Bandres-Ciga, Rainer von Coelln, Lasse Pihlstrøm, Javier Simón-Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn, Ari Siitonen, Hirotaka Iwaki, Hampton Leonard, Alastair J Noyce, Manuela Tan, J Raphael Gibbs, Dena G Hernandez, Sonja W Scholz, Joseph Jankovic, Lisa M Shulman, Suzanne Lesage, Jean-Christophe Corvol, Alexis Brice, Jacobus J van Hilten, Johan Marinus, Johanna Eerola-Rautio, Pentti Tienari, Kari Majamaa, Mathias Toft, Donald G Grosset, Thomas Gasser, Peter Heutink, Joshua M Shulman, Nicolas Wood, John Hardy, Huw R Morris, David A Hinds, Jacob Gratten, Peter M Visscher, Ziv Gan-Or, Mike A Nalls, Andrew B Singleton
BACKGROUND: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age at onset are largely unknown. OBJECTIVES: To identify the genetic determinants of PD age at onset. METHODS: Using genetic data of 28,568 PD cases, we performed a genome-wide association study based on PD age at onset...
April 7, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938893/association-of-statin-use-with-parkinson-s-disease-dose-response-relationship
#11
Su-Min Jeong, Wooyoung Jang, Dong Wook Shin
BACKGROUND: There have been conflicting results on the association between statin use and Parkinson's disease (PD) incidence. OBJECTIVES: This study investigated the association between time-varying status of statin use and incidence of PD while considering the dose-response relationship and total cholesterol level. METHODS: Using the database of the Korean National Health Insurance Service from 2002 to 2015, we examined 76,043 subjects (≥60 years old) free of PD, dementia, and stroke at baseline...
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938892/mild-cognitive-impairment-in-de-novo-parkinson-s-disease-a-neuromelanin-mri-study-in-locus-coeruleus
#12
Yuanfang Li, Changpeng Wang, Jian Wang, Ying Zhou, Fang Ye, Yong Zhang, Xiaoqin Cheng, Zhen Huang, Kai Liu, Guoqiang Fei, Chunjiu Zhong, Mengsu Zeng, Lirong Jin
BACKGROUND: We aimed to investigate neuromelanin-sensitive magnetic resonance imaging (NM-MRI) features in the locus coeruleus of de novo Parkinson's disease patients with different cognitive states and to determine whether these features are associated with cognitive impairment. METHODS: Three groups of subjects were recruited in this study, including patients with de novo PD with mild cognitive impairment (n = 23), patients with de novo PD without cognitive impairment (n = 48), and control subjects (n = 32)...
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938861/cholinergic-interneurons-drive-maladaptive-changes-in-thalamostriatal-circuitry-after-dopamine-depletion
#13
Jay Li, William Dauer
No abstract text is available yet for this article.
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938852/a-special-issue-on-childhood-onset-movement-disorders
#14
EDITORIAL
Darius Ebrahimi-Fakhari, Alexander Münchau, Maria Stamelou
No abstract text is available yet for this article.
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938851/minimal-clinically-important-difference-for-the-quality-of-life-in-essential-tremor-questionnaire
#15
LETTER
Dávid Pintér, Attila Makkos, Márton Kovács, József Janszky, Norbert Kovács
No abstract text is available yet for this article.
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30938849/yerba-mate-ilex-paraguariensis-favors-survival-and-growth-of-dopaminergic-neurons-in-culture
#16
LETTER
Alejandra Bernardi, Pedro Ballestero, Marcela Schenk, Mariana Ferrario, Gimena Gómez, Roy Rivero, Elena Avale, Irene Taravini, Oscar Gershanik, Sandra Guerrero, Juan E Ferrario
No abstract text is available yet for this article.
April 2, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30933382/pediatric-freezing-of-gait-caused-by-anti-nmdar-encephalitis
#17
LETTER
Gaetano Cantalupo, Alfonso Fasano
No abstract text is available yet for this article.
April 1, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30924964/network-basis-of-the-dysexecutive-and-posterior-cortical-cognitive-profiles-in-parkinson-s-disease
#18
Stefan Lang, Alexandru Hanganu, Liu Shi Gan, Mekale Kibreab, Noémie Auclair-Ouellet, Tazrina Alrazi, Mehrafarin Ramezani, Jenelle Cheetham, Tracy Hammer, Iris Kathol, Justyna Sarna, Oury Monchi
BACKGROUND: The dual syndrome hypothesis of cognitive impairment in PD suggests that two cognitive profiles exist with distinct pathological mechanisms and a differential risk for further cognitive decline. How these profiles relate to network dysfunction has never been explicitly characterized. OBJECTIVE: First, to assess intranetwork functional connectivity while considering global connectivity, and second, to relate network connectivity with measures of the dysexecutive and posterior cortical profiles...
March 29, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30919519/current-therapies-and-therapeutic-decision-making-for-childhood-onset-movement-disorders
#19
REVIEW
Shekeeb S Mohammad, Simon P Paget, Russell C Dale
Movement disorders differ in children to adults. First, neurodevelopmental movement disorders such as tics and stereotypies are more prevalent than parkinsonism, and second, there is a genomic revolution which is now explaining many early-onset dystonic syndromes. We outline an approach to children with movement disorders starting with defining the movement phenomenology, determining the level of functional impairment due to abnormal movements, and screening for comorbid psychiatric conditions and cognitive impairments which often contribute more to disability than the movements themselves...
March 28, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/30919499/prodromal-parkinson-s-disease-the-decade-past-the-decade-to-come
#20
REVIEW
Ronald B Postuma, Daniela Berg
The past decade has seen a dramatic expansion of the field of prodromal PD. Ten years ago, there were only six known prodromal markers of disease, none of which had more than two studies documenting diagnostic value. We now have at least 16 markers, with as many as 10 prospective studies for a single marker. This review summarizes the major advances over the next decade and speculates about the advances we will see in the decade to come. The most notable advances over the last decade came through the study of high-risk cohorts (REM sleep behavior disorder and later genetic and autonomic cohorts), the generation of more representative population-based cohorts for studying prodromal PD, major advances in neuroimaging of early disease stages, the emerging likelihood that tissue biopsy will be able to diagnose prodromal PD, and the coalescence of prodromal markers into discrete criteria...
March 28, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
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