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Movement Disorders: Official Journal of the Movement Disorder Society | Page 2

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https://read.qxmd.com/read/31234224/no-link-between-striatal-dopaminergic-axons-and-dopamine-transporter-imaging-in-parkinson-s-disease
#21
Emma A Honkanen, Laura Saari, Katri Orte, Maria Gardberg, Tommi Noponen, Juho Joutsa, Valtteri Kaasinen
BACKGROUND: Brain dopamine transporter binding has been considered a possible biomarker for nigrostriatal degeneration in PD. OBJECTIVE: To investigate whether dopamine transporter binding is associated with the number of dopaminergic neurites in the putamen. METHODS: Tyrosine hydroxylase-positive nerve fibers were counted from postmortem putamen sections taken from 14 parkinsonism patients who had been scanned with dopamine transporter single-photon emission computed tomography antemortem...
June 24, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31234223/change-in-some-quality-of-life-domains-mimics-change-in-tremor-severity-after-ultrasound-thalamotomy
#22
LETTER
Nadia Scantlebury, Ying Meng, Nir Lipsman, Jennifer Jain, Deirdre Dawson, Michael L Schwartz
No abstract text is available yet for this article.
June 24, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31216379/changing-views-of-the-pathophysiology-of-parkinsonism
#23
REVIEW
Thomas Wichmann
Studies of the pathophysiology of parkinsonism (specifically akinesia and bradykinesia) have a long history and primarily model the consequences of dopamine loss in the basal ganglia on the function of the basal ganglia/thalamocortical circuit(s). Changes of firing rates of individual nodes within these circuits were originally considered central to parkinsonism. However, this view has now given way to the belief that changes in firing patterns within the basal ganglia and related nuclei are more important, including the emergence of burst discharges, greater synchrony of firing between neighboring neurons, oscillatory activity patterns, and the excessive coupling of oscillatory activities at different frequencies...
June 19, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31216378/frequency-and-phenotypic-spectrum-of-kmt2b-dystonia-in-childhood-a-single-center-cohort-study
#24
Miryam Carecchio, Federica Invernizzi, Paulina Gonzàlez-Latapi, Celeste Panteghini, Giovanna Zorzi, Luigi Romito, Vincenzo Leuzzi, Serena Galosi, Chiara Reale, Federica Zibordi, Agnel P Joseph, Maya Topf, Carla Piano, Anna Rita Bentivoglio, Floriano Girotti, Paolo Morana, Benedetto Morana, Manju A Kurian, Barbara Garavaglia, Niccolò E Mencacci, Steven J Lubbe, Nardo Nardocci
BACKGROUND: Childhood-onset dystonia is often genetically determined. Recently, KMT2B variants have been recognized as an important cause of childhood-onset dystonia. OBJECTIVE: To define the frequency of KMT2B mutations in a cohort of dystonic patients aged <18 years at onset, the associated clinical and radiological phenotype, and the natural history of disease. METHODS: Whole-exome sequencing or customized gene panels were used to screen a cohort of 65 patients who had previously tested negative for all other known dystonia-associated genes...
June 19, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31211471/roles-of-the-m-4-acetylcholine-receptor-in-the-basal-ganglia-and-the-treatment-of-movement-disorders
#25
Mark S Moehle, P Jeffrey Conn
Acetylcholine (ACh) released from cholinergic interneurons acting through nicotinic and muscarinic acetylcholine receptors (mAChRs) in the striatum have been thought to be central for the potent cholinergic regulation of basal ganglia activity and motor behaviors. ACh activation of mAChRs has multiple actions to oppose dopamine (DA) release, signaling, and related motor behaviors and has led to the idea that a delicate balance of DA and mAChR signaling in the striatum is critical for maintaining normal motor function...
June 18, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31211469/remote-monitoring-of-treatment-response-in-parkinson-s-disease-the-habit-of-typing-on-a-computer
#26
Michele Matarazzo, Teresa Arroyo-Gallego, Paloma Montero, Verónica Puertas-Martín, Ian Butterworth, Carlos S Mendoza, María J Ledesma-Carbayo, María José Catalán, José Antonio Molina, Félix Bermejo-Pareja, Juan Carlos Martínez-Castrillo, Lydia López-Manzanares, Araceli Alonso-Cánovas, Jaime Herreros Rodríguez, Ignacio Obeso, Pablo Martínez-Martín, José Carlos Martínez-Ávila, Agustín Gómez de la Cámara, Martha Gray, José A Obeso, Luca Giancardo, Álvaro Sánchez-Ferro
OBJECTIVE: The recent advances in technology are opening a new opportunity to remotely evaluate motor features in people with Parkinson's disease (PD). We hypothesized that typing on an electronic device, a habitual behavior facilitated by the nigrostriatal dopaminergic pathway, could allow for objectively and nonobtrusively monitoring parkinsonian features and response to medication in an at-home setting. METHODS: We enrolled 31 participants recently diagnosed with PD who were due to start dopaminergic treatment and 30 age-matched controls...
June 18, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31211461/prediction-of-survival-with-long-term-disease-progression-in-most-common-spinocerebellar-ataxia
#27
Alhassane Diallo, Heike Jacobi, Arron Cook, Paola Giunti, Michael H Parkinson, Robyn Labrum, Alexandra Durr, Alexis Brice, Perrine Charles, Cecilia Marelli, Caterina Mariotti, Lorenzo Nanetti, Marta Panzeri, Anna Castaldo, Maria Rakowicz, Rafal Rola, Anna Sulek, Tanja Schmitz-Hübsch, Ludger Schöls, Holger Hengel, Laszlo Baliko, Bela Melegh, Alessandro Filla, Antonella Antenora, Jon Infante, José Berciano, Bart P van de Warrenburg, Dagmar Timmann, Sylvia Boesch, Wolfgang Nachbauer, Massimo Pandolfo, Jörg B Schulz, Peter Bauer, Kang Jun-Suk, Thomas Klockgether, Sophie Tezenas du Montcel
BACKGROUND: Spinocerebellar ataxias are rare dominantly inherited neurodegenerative diseases that lead to severe disability and premature death. OBJECTIVE: To quantify the impact of disease progression measured by the Scale for the Assessment and Rating of Ataxia on survival, and to identify different profiles of disease progression and survival. METHODS: Four hundred sixty-two spinocerebellar ataxia patients from the EUROSCA prospective cohort study, suffering from spinocerebellar ataxia type 1, spinocerebellar ataxia type 2, spinocerebellar ataxia type 3, and spinocerebellar ataxia type 6, and who had at least two measurements of Scale for the Assessment and Rating of Ataxia score, were analyzed...
June 18, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31211450/hyposkillia-and-spanophilia-in-the-movement-disorders-rounds
#28
LETTER
Hélio A G Teive, Carlos Henrique F Camargo, Salmo Raskin, Renato P Munhoz, Francisco E C Cardoso
No abstract text is available yet for this article.
June 18, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31211448/randomized-phase-i-clinical-trial-of-anti-%C3%AE-synuclein-antibody-biib054
#29
Miroslaw Brys, Laura Fanning, Serena Hung, Aaron Ellenbogen, Natalia Penner, Minhua Yang, Mackenzie Welch, Erica Koenig, Eric David, Tara Fox, Shavy Makh, Jason Aldred, Ira Goodman, Blake Pepinsky, YuTing Liu, Danielle Graham, Andreas Weihofen, Jesse M Cedarbaum
BACKGROUND: Pathological and genetic evidence implicates toxic effects of aggregated α-synuclein in the pathophysiology of neuronal dysfunction and degeneration in Parkinson's disease. Immunotherapy targeting aggregated α-synuclein is a promising strategy for delaying disease progression. OBJECTIVE: This study (NCT02459886) evaluated the safety, tolerability, and pharmacokinetics of BIIB054, a human-derived monoclonal antibody that preferentially binds to aggregated α-synuclein, in healthy volunteers and participants with Parkinson's disease...
June 17, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31206796/you-shall-not-pass-gut-bacteria-can-convert-levodopa-to-dopamine
#30
Hugo Morales-Briceño, Victor S C Fung
No abstract text is available yet for this article.
June 17, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31189032/dementia-with-lewy-bodies-gba1-mutations-are-associated-with-cerebrospinal-fluid-alpha-synuclein-profile
#31
Stefanie Lerche, Gerrit Machetanz, Isabel Wurster, Benjamin Roeben, Milan Zimmermann, Andrea Pilotto, Oliver Preische, Elke Stransky, Christian Deuschle, Ann-Kathrin Hauser, Claudia Schulte, Ingolf Lachmann, Katharina Waniek, Thomas Gasser, Daniela Berg, Walter Maetzler, Kathrin Brockmann
BACKGROUND: Patients with dementia with Lewy bodies reveal a variable pathology including alpha-synuclein, amyloid-beta, and Tau. Mutations in GBA1 are specifically associated with synucleinopathies. PD patients with GBA1 mutations show reduced CSF levels of total alpha-synuclein. OBJECTIVE: Whether GBA1 mutations are associated with a CSF alpha-synuclein profile in dementia with Lewy bodies. METHODS: Screening of the GBA1 gene and single-nucleotide polymorphisms in SNCA rs356220, APOE rs429358, and MAPT rs1052587 as well as CSF levels of total alpha-synuclein, amyloid-beta1-42 , total-Tau, phospho-Tau, and neurofilament light chain were assessed in 100 dementia with Lewy bodies and 39 controls cross-sectionally...
June 12, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31180620/repetitive-transcranial-magnetic-stimulation-for-functional-tremor-a-randomized-double-blind-controlled-study
#32
Simon Taib, Fabienne Ory-Magne, Christine Brefel-Courbon, Ysé Moreau, Claire Thalamas, Christophe Arbus, Marion Simonetta-Moreau
OBJECTIVES: The objective of this study was to compare the effect on functional tremor of active versus sham repetitive transcranial magnetic stimulation and investigate whether the addition of hypnosis might help to prolong any repetitive transcranial magnetic stimulation-induced therapeutic effect. METHODS: We compared the effect of 5 consecutive daily sessions of active/sham repetitive transcranial magnetic stimulation on functional tremor, at 1 and 2 months, in a randomized, double-blind, 2-arm, parallel-controlled study...
June 10, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31180615/ventral-posterior-substantia-nigra-iron-increases-over-3-years-in-parkinson-s-disease
#33
Niels Bergsland, Robert Zivadinov, Ferdinand Schweser, Jesper Hagemeier, David Lichter, Thomas Guttuso
BACKGROUND: Parkinson's disease (PD) is characterized in part by the progressive accumulation of iron within the substantia nigra (SN); however, its spatial and temporal dynamics remain relatively poorly understood. OBJECTIVES: The objective of this study was to investigate spatial patterns and temporal evolution of SN iron accumulation in PD. METHODS: A total of 18 PD patients (mean disease duration = 6.2 years) receiving dopaminergic therapy and 16 healthy controls were scanned with 3T MRI at baseline and 3 years later using quantitative susceptibility mapping, an indirect marker of iron content...
June 10, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31180613/parkinsonism-in-essential-tremor-cases-a-clinicopathological-study
#34
Ali H Rajput, Emma F Rajput, Sarah M Bocking, Roland N Auer, Alex Rajput
BACKGROUND: Essential tremor and Parkinson's syndrome are two common movement disorders that may co-occur in some individuals. There is no diagnostic neuropathology for essential tremor, but in PD and other Parkinson's syndrome variants, the neuropathology is well known. The spectrum of Parkinson's syndrome variants associated with essential tremor, their clinical features, and course have not been determined in autopsy-confirmed cases. OBJECTIVES: To identify: diagnostic features of essential tremor/Parkinson's syndrome, different Parkinson's syndrome variants, and long-term clinical profile in such cases...
June 10, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31180598/sex-related-pattern-of-intrinsic-brain-connectivity-in-drug-na%C3%A3-ve-parkinson-s-disease-patients
#35
Rosa De Micco, Fabrizio Esposito, Federica di Nardo, Giuseppina Caiazzo, Mattia Siciliano, Antonio Russo, Mario Cirillo, Gioacchino Tedeschi, Alessandro Tessitore
BACKGROUND: Sex difference is related to specific clinical features in PD patients over the disease course. OBJECTIVES: To investigate the potential sex-difference effect on the spontaneous neuronal activity within the most reported resting-state networks in early untreated PD patients and its correlation with baseline and longitudinal clinical features. METHODS: Fifty-six drug-naïve PD patients (30/26 male/female) and 30 (15/15 male/female) matched controls were enrolled in the study...
June 10, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31158314/comparison-of-phosphodiesterase-10a-and-dopamine-transporter-levels-as-markers-of-disease-burden-in-early-parkinson-s-disease
#36
Gennaro Pagano, Flavia Niccolini, Heather Wilson, Tayyabah Yousaf, Naheed L Khan, Davide Martino, Christophe Plisson, Roger N Gunn, Eugenii A Rabiner, Paola Piccini, Thomas Foltynie, Marios Politis
BACKGROUND: Recent work has shown loss of phosphodiesterase 10A levels in middle-stage and advanced treated patients with PD, which was associated with motor symptom severity. OBJECTIVES: To assess phosphodiesterase 10A levels in early PD and compare with loss of dopamine transporter as markers of disease burden. METHODS: Seventy-eight subjects were included in this study (17 early de novo, 15 early l-dopa-treated, 24 moderate-advanced l-dopa-treated patients with PD, and 22 healthy controls)...
June 3, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31145831/trial-of-magnetic-resonance-guided-putaminal-gene-therapy-for-advanced-parkinson-s-disease
#37
John D Heiss, Codrin Lungu, Dima A Hammoud, Peter Herscovitch, Debra J Ehrlich, Davis P Argersinger, Sanhita Sinharay, Gretchen Scott, Tianxia Wu, Howard J Federoff, Kareem A Zaghloul, Mark Hallett, Russell R Lonser, Krystof S Bankiewicz
OBJECTIVE: To investigate the safety and tolerability of convection-enhanced delivery of an adeno-associated virus, serotype-2 vector carrying glial cell line-derived neurotrophic factor into the bilateral putamina of PD patients. METHODS: Thirteen adult patients with advanced PD underwent adeno-associated virus, serotype-2 vector carrying glial cell line-derived neurotrophic factor and gadoteridol (surrogate MRI tracer) coinfusion (450 μL/hemisphere) at escalating doses: 9 × 1010 vg (n = 6); 3 × 1011 vg (n = 6); and 9 × 1011 vg (n = 1)...
May 30, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31145819/the-issue-of-waste-disposal-in-parkinson-s-disease-pathogenesis
#38
Lucilla Parnetti, Giovanni Bellomo
No abstract text is available yet for this article.
May 30, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31136698/the-a1-astrocyte-paradigm-new-avenues-for-pharmacological-intervention-in-neurodegeneration
#39
Jared T Hinkle, Valina L Dawson, Ted M Dawson
We recently demonstrated that NLY01, a novel glucagon-like peptide-1 receptor agonist, exerts neuroprotective effects in two mouse models of PD in a glia-dependent manner. NLY01 prevented microglia from releasing inflammatory mediators known to convert astrocytes into a neurotoxic A1 reactive subtype. Importantly, we provided evidence that this neuroprotection was not mediated by a direct action of NLY01 on neurons or astrocytes (e.g., by activating neurotrophic pathways or modulating astrocyte reactivity per se)...
May 28, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/31136681/scales-to-assess-impulsive-and-compulsive-behaviors-in-parkinson-s-disease-critique-and-recommendations
#40
REVIEW
Andrew H Evans, David Okai, Daniel Weintraub, Shen-Yang Lim, Sean S O'Sullivan, Valerie Voon, Paul Krack, Cristina Sampaio, Bart Post, Albert F G Leentjens, Pablo Martinez-Martin, Glenn T Stebbins, Christopher G Goetz, Anette Schrag
Impulse control disorders (ICDs) and related impulsive and compulsive behaviors (together called ICBs) have been increasingly recognized in the context of Parkinson's disease (PD) and treatment. The International Parkinson's and Movement Disorder Society commissioned a task force to assess available clinical screening instruments and rating scales, including their clinimetric properties, make recommendations regarding their utility, and suggest future directions in scale development and validation. The literature was systematically searched for scales measuring a range of reported ICBs in PD...
May 28, 2019: Movement Disorders: Official Journal of the Movement Disorder Society
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