journal
https://read.qxmd.com/read/38789100/notch-2-signaling-contributes-to-intestinal-eosinophil-adaptations-in-steady-state-and-tissue-burden-following-oral-allergen-challenge
#1
JOURNAL ARTICLE
Stephen A Schworer, Courtney L Olbrich, Leigha D Larsen, Emily Howard, Linying Liu, Kenya Koyama, Lisa A Spencer
Eosinophils function as inflammatory effectors in allergic diseases but also contribute to tissue homeostasis in steady state. Emerging data are revealing tissue eosinophils to be adaptive cells, imprinted by their local tissue microenvironment and exhibiting distinct functional phenotypes that may contribute to their homeostatic versus inflammatory capacities. However, signaling pathways that regulate eosinophil tissue adaptations remain elusive. Notch signaling is an evolutionarily conserved pathway that mediates differential cell fate programming of both pre- and post-mitotic immune cells...
May 24, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38785336/macrophage-specific-lipoxygenase-deletion-amplify-cardiac-repair-activating-tregs-in-chronic-heart-failure
#2
JOURNAL ARTICLE
Vasundhara Kain, Gabriel Araujo Grilo, Gunjan Upadhyay, Jerry L Nadler, Charles N Serhan, Ganesh V Halade
Splenic leukocytes, particularly macrophage-expressed lipoxygenases, facilitate the biosynthesis of resolution mediators essential for cardiac repair. Next, we asked whether deletion of 12/15 lipoxygenase (12/15LOX) in macrophages impedes the resolution of inflammation following myocardial infarction (MI). Using 12/15flox/flox and LysMcre scheme, we generated macrophage-specific 12/15LOX (Mɸ-12/15LOX-/-) mice. Young C57BL/6J wild-type and Mɸ-12/15LOX-/- male mice were subjected to permanent coronary ligation micro-surgery...
May 24, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38785333/tigit-stimulation-suppresses-autoimmune-uveitis-by-inhibiting-th17-cell-infiltration
#3
JOURNAL ARTICLE
Kayleigh Peters, Trisha McDonald, Fauziyya Muhammad, Adrien Brady, John Dostal, Darren J Lee
T cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint molecule that suppresses T cell activation and promotes an immunosuppressive environment to suppress autoimmune diseases. However, the impact of a TIGIT agonist as a treatment for ocular autoimmune disease has not been investigated. We examined TIGIT expression on Th17 and Treg cells, the role of TIGIT on experimental autoimmune uveitis (EAU) and Th17 cells, and the impact of Treg generation following TIGIT stimulation. TIGIT stimulation at the onset of clinical symptoms reduced the severity of uveitis and suppressed infiltration of Th17 cells into the eye...
May 24, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38776408/elevations-in-presepsin-pct-hs-crp-and-il-6-levels-predict-mortality-among-septic-patients-in-icu
#4
JOURNAL ARTICLE
Yan Zhou, Yongwen Feng, Xiaomin Liang, Shuiqing Gui, Di Ren, Yuanzhi Liu, Jijia She, Xiaomei Zhang, Fei Song, Lina Yu, Yiwen Zhang, Jinping Wang, Zhiye Zou, Jiang Mei, Sha Wen, Mei Yang, Xinsi Li, Xuerui Tan, Ying Li
BACKGROUND: Aim to investigate the predictive value of changes in presepsin (PSEP), procalcitonin (PCT), high-sensitivity C-reactive protein (hsCRP), and interleukin-6 (IL-6) levels to for mortality in septic patients in intensive care unit (ICU). METHOD: This study enrolled septic patients between November 2020 and December 2021. Levels of PSEP, PCT, hsCRP, and IL-6 were measured on 1st (PSEP_0, PCT_0, hsCRP_0, IL-6_0) and 3rd day (PSEP_3, PCT_3, hsCRP_3, IL-6_3)...
May 22, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38758953/the-role-of-cathelicidins-in-neutrophil-biology
#5
JOURNAL ARTICLE
Grace Yoon, Rodrigo Puentes, Jacquelyn Tran, Anmol Multani, Eduardo R Cobo
Despite their relatively short lifespan, neutrophils are tasked with counteracting pathogens through various functions, including phagocytosis, production of reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and host defence peptides. Regarding the latter, small cationic cathelicidins present a conundrum in neutrophil function. Although primarily recognized as microbicides with an ability to provoke pores in microbial cell walls, the ability of cathelicidin to modulate key neutrophil functions is also of great importance, including the release of chemo-attractants, cytokines and ROS, plus prolonging neutrophil lifespan...
May 17, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38758950/unraveling-immune-heterogeneity-across-pan-cancer-and-deep-insights-in-lung-adenocarcinoma-based-on-alternative-splicing
#6
JOURNAL ARTICLE
Yuquan Wang, Erliang Guo, Min Zou, Chen Lv, Yanrui Cui, Songmei Zhai, Shaocong Sang, Kai Xiong, Xiuqi Yang, Shuping Zhuang, Yunyan Gu, Haihai Liang
Alternative splicing (AS) participates in tumor development and tumor microenvironment formation. However, the landscape of immune infiltrating AS events (IIASE) in pan-cancer and mechanisms of AS in lung adenocarcinoma (LUAD) have not been comprehensively characterized. We systematically profiled the IIASE landscape of pan-cancer using data from The Cancer Genome Atlas (TCGA), analyzing both commonalities and specific characteristics among different cancer types. We found that AS events tend to occur specifically in one cancer type rather than in multiple cancer types...
May 17, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38753658/the-anti-tumor-effect-of-extracellular-vesicles-derived-from-cytokine-activated-cd8-t-cells
#7
JOURNAL ARTICLE
Lin Zhang, Yuan Meng, Yang An, Xuena Yang, Feng Wei, Xiubao Ren
Extracellular vesicles (EVs) are the nano-sized membrane particles secreted by various cell types, which are involved in many important cellular processes. Recently, EVs originating from immune cells, such as dendritic cells, chimeric antigen receptor T cells (CAR-T) and natural killer cells, have attracted much attention because of their known direct and indirect antitumor activity. Here, we report the EVs released by cytokine-activated CD8 + T cells (caCD8) and its cytotoxicity against cancer cells...
May 16, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38748862/modeling-of-host-pdz-dependent-interactions-with-sars-cov-2-envelope-protein-and-changes-in-pdz-proteins-expression-in-macrophages-and-dendritic-cells
#8
JOURNAL ARTICLE
Jorge Rosas-García, Alberta Jaqueline Padilla-Zúñiga, Antonia Ávila-Flores, Luis Horacio Gutiérrez-González, Isabel Mérida, Teresa Santos-Mendoza
PDZ (PSD-95/Dlg/ZO-1) domain-containing proteins constitute a large family of scaffolds involved in a wide range of cellular tasks, and mainly studied in polarity functions. Diverse host PDZ proteins can be targeted by viral pathogens which express proteins containing PDZ-binding motifs (PDZbm). Previously, we have identified host PDZ-based interactions with the SARS-CoV-2 E protein (2E) in human monocytes. Here, we deepen the study of these interactions by docking and molecular dynamics analyses to identify the most favorable PDZ-PDZbm interaction of seven host PDZ proteins with the PDZbm of 2E...
May 15, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38748684/treponema-pallidum-recombinant-protein-tp0768-enhances-the-ability-of-huvecs-to-promote-neutrophil-chemotaxis-through-tlr2-er-stress-signaling-pathway
#9
JOURNAL ARTICLE
Ting Cao, Yue Li, Xiangping Zhou, Yun Tang, Bisha He, Qian Cao, Yibao Hu, En Chen, Yumeng Li, Xiaoping Xie, Feijun Zhao, Xiaopeng Lan, Shuangquan Liu
Neutrophils are essential cells involved in inflammation. However, the specific mechanism of neutrophil chemotaxis induced by Treponema Pallidum (T. pallidum) remains unknow. In this study, human umbilical vein endothelial cells (HUVECs) were utilized as target cells to investigate the expression levels of chemokines when stimulated with different concentrations of Tp0768(also known as TpN44.5 or TmpA, a T. pallidum infection dependent antigen). The results indicated that Tp0768 treatment enhanced neutrophil chemotaxis in HUVECs, which was closely associated with the expression levels of CXCL1(C-X-C Motif Chemokine Ligand 1), CXCL2(C-X-C Motif Chemokine Ligand 2), and CXCL8(C-X-C Motif Chemokine Ligand 8, also known as interleukin-8)...
May 15, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38736141/considerations-on-the-evolutionary-biology-and-functions-of-eosinophils-what-the-haeckel
#10
JOURNAL ARTICLE
Steven J Ackerman, Nicole I Stacy
The origins and evolution of the eosinophilic leukocyte has received only scattered attention since Paul Ehrlich first named this granulocyte. Studies suggest that myeloperoxidase, expressed by granulocytes, and eosinophil peroxidase diverged some 60-70 million years ago, but invertebrate to vertebrate evolution of the eosinophil lineage is unknown. Vertebrate eosinophils have been characterized extensively in representative species at light microscopic, ultrastructural, genetic, and biochemical levels. Understanding of eosinophil function continues to expand and includes to date regulation of "Local Immunity And/Or Remodeling/Repair" (the so-called LIAR hypothesis), modulation of innate and adaptive immune responses, maintenance of tissue and metabolic homeostasis, and under pathologic conditions, inducers of tissue damage, repair, remodeling, and fibrosis...
May 13, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38734968/factors-affecting-neutrophil-functions-during-sepsis-human-microbiome-and-epigenetics
#11
JOURNAL ARTICLE
Yina Ma, Yu Zhao, Xin Zhang
Sepsis is a severe disease that occurs when the body's immune system reacts excessively to infection. The body's response, which includes an intense anti-bacterial reaction, can damage its tissues and organs. Neutrophils are the major components of white blood cells in circulation and play a vital role in innate immunity while fighting against infections, and are considered a feature determining sepsis classification. There's a plethora of basic research detailing neutrophil functioning, among which, the study of neutrophil extracellular traps (NETs) is providing novel insights into mechanisms and treatments of sepsis...
May 12, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38727078/accumulation-of-lipid-droplets-induced-by-listeria-monocytogenes-in-macrophages-implications-for-survival-and-evasion-of-innate-immunity
#12
JOURNAL ARTICLE
Filipe S Pereira-Dutra, Ellen K Souza, Tamyris S Souza, Taynná C Goltara-Gomes, Felipe Ferraro-Moreira, Lohanna Palhinha, Tamires Cunha-Fernandes, Matheus A Rajão, Adriana R Silva, Patrícia T Bozza
Listeriosis, caused by Listeria monocytogenes (L.m.), poses a significant public health concern as one of the most severe foodborne diseases. The pathogenesis of L.m. involves critical steps such as phagosome rupture and escape upon internalization. Throughout infection, L.m. influences various host processes, including lipid metabolism pathways, yet the role of lipid droplets (LDs) remains unclear. Here, we reported a rapid, time-dependent increase in LD formation in macrophages induced by L.m. LD biogenesis was found to be dependent on L...
May 10, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38725289/prp-is-cleaved-from-the-surface-of-mast-cells-by-adam10-and-proteases-released-during-degranulation
#13
JOURNAL ARTICLE
Steven D Willows, Harissios Vliagoftis, Valerie L Sim, Marianna Kulka
While several functions of the endogenous prion protein (PrP) have been studied, the homeostatic function of PrP is still debated. Notably, PrP is highly expressed on mast cells, granular immune cells that regulate inflammation. When activated, mast cells shed PrP though the mechanism and consequences of this are not yet understood. First, we tested several mast cell lines and found that, while PrP was almost always present, the total amount differed greatly. Activation of mast cells induced a cleavage of the N-terminal region of PrP, and this was reduced by protease inhibitors...
May 10, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38723185/eosinophil-specialization-is-regulated-by-exposure-to-the-esophageal-epithelial-microenvironment
#14
JOURNAL ARTICLE
Julia L M Dunn, Andrea Szep, Emily Gonzalez Galan, Simin Zhang, Justin Marlman, Julie Caldwell, Ty D Troutman, Marc E Rothenberg
Distinct subsets of eosinophils are reported in inflammatory and healthy tissues, yet the functions of uniquely specialized eosinophils and the signals that elicit them, particularly in eosinophilic esophagitis (EoE), are not well understood. Herein, we report an ex-vivo system wherein freshly isolated human eosinophils were cocultured with esophageal epithelial cells and disease-relevant pro-inflammatory (IL-13) or pro-fibrotic (TGF-β) cytokines. Compared with untreated cocultures, IL-13 increased expression of CD69 on eosinophils, whereas TGF-β increased expression of CD81, CD62L, and CD25...
May 9, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38721720/functions-of-n6-methyladenosine-m6a-rna-modifications-in-acute-myeloid-leukemia
#15
JOURNAL ARTICLE
Zehao Fang, Hanyi Ding, Jiongping Han, Leihua Fu, Jing Jin, Weiying Feng
N6-methyladenosine (m6A) is the most common modification of eukaryotic RNA. m6A participates in RNA splicing, nuclear export, translation, and degradation through regulation by methyltransferases, methylation readers, and demethylases, affecting mRNA stability and translation efficiency. Through the dynamic and reversible regulatory network composed of " Writers-Erasers-Readers", m6A modification plays a unique role in the process of hematopoiesis. Acute myeloid leukemia (AML) is a heterogeneous disease characterized by malignant proliferation of hematopoietic stem cells/progenitor cells...
May 9, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38717738/presence-of-sars-cov-2-specific-t-cells-before-vaccination-in-the-mexican-population
#16
JOURNAL ARTICLE
Gabriela Hernandez-Galicia, Luis Gomez-Morales, Luis Uriel Lopez-Bailon, Humberto Valdovinos-Torres, Carla O Contreras-Ochoa, Cinthya Estefhany Díaz Benítez, Jesus Martinez-Barnetche, Celia Alpuche-Aranda, Vianney Ortiz-Navarrete
The immune response to SARS-CoV-2 has been extensively studied following the pandemic outbreak in 2020; however, the presence of specific T cells against SARS-CoV-2 before vaccination has not been evaluated in Mexico. In this study, we estimated the frequency of T CD4+ and T CD8+ cells that exhibit a specific response to S (spike) and N (nucleocapsid) proteins in a Mexican population. We collected 78 peripheral blood samples from unvaccinated subjects and the presence of antibodies against spike (RBD) and N protein was determined...
May 8, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38713770/irg1-acod1-promotes-neutrophil-reverse-migration-and-alleviates-local-inflammation
#17
JOURNAL ARTICLE
Jingjing Ji, Hanhui Zhong, Yuehua Li, Timothy R Billiar, Mark A Wilson, Melanie J Scott, Jie Fan
Polymorphonuclear neutrophil (PMN) infiltration at inflammatory site plays a critical role in inflammation. PMN reverse migration (rM) describes the phenomenon that PMNs migrate away from inflammatory site back into the vasculature, and its role within inflammatory scenarios remains to be fully determined. This study aimed to investigate the mechanism underlying PMN rM and its role in inflammation. First, we demonstrated PMN rM in a mouse model of LPS-induced acute lung inflammation. By single-cell RNA sequencing (scRNA-seq), we demonstrated that reverse migrated (rM-ed) PMNs in blood expressed high level of immuneresponsive gene 1 (Irg1), the encoding gene of cis-aconitate decarboxylase (ACOD1)...
May 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38713107/t-cell-responses-in-immune-mediated-iga-nephropathy
#18
JOURNAL ARTICLE
Shimin Xie, Mengying Sun, Xiaohan Zhang, Chao Kan, Guojuan Shi, Weixiang Peng, Junli Guo, Dantong Wu, Zhinan Yin, Quanli Yang, Rui Zhang
Immunoglobulin A nephropathy (IgAN) is a complex autoimmune disease with various underlying causes and significant clinical heterogeneity. There are large individual differences in its development, and the etiology and pathogenesis are still poorly understood. While it is known that immunobiological factors play a significant role in the pathophysiology of IgAN, the specific nature of these factors has yet to be fully elucidated. Numerous investigations have verified that cluster of differentiation 4+ (CD4+) and CD8+ T lymphocytes are involved in the immunopathogenesis of IgAN...
May 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38713106/the-fat-controller-an-unexpected-role-of-selenoi-in-igm-responses
#19
JOURNAL ARTICLE
Mats Bemark
No abstract text is available yet for this article.
May 7, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38701199/the-aryl-hydrocarbon-receptor-ahr-repressor-limits-expression-of-antimicrobial-genes-but-not-ahr-dependent-genes-in-intestinal-eosinophils
#20
JOURNAL ARTICLE
Heike Weighardt, Michael Shapiro, Michelle Mayer, Irmgard Förster, Brigitta Stockinger, Nicola Laura Diny
Intestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-activated transcription factor that responds to dietary or environmental ligands. AHR regulates tissue adaptation, survival, adhesion, and immune functions in intestinal eosinophils. The AHR repressor (AHRR) is itself induced by AHR and believed to limit AHR activity in a negative feedback loop. We analysed gene expression in intestinal eosinophils from WT and AHRR-KO mice and found that AHRR did not suppress most AHR-dependent genes...
May 3, 2024: Journal of Leukocyte Biology
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