Jhefferson Barbosa Guimarães, Vanessa Fernandes Rodrigues, Ítalo Sousa Pereira, Gabriel Martins da Costa Manso, Jefferson Elias-Oliveira, Jefferson Antônio Leite, Mariana Camila Gonçalves Miranda Waldetario, Sarah de Oliveira, Arilson Bernardo Dos Santos Pereira Gomes, Ana Maria Caetano Faria, Simone Gusmão Ramos, Vânia L D Bonato, João Santana Silva, Marco Aurélio Ramirez Vinolo, Ulliana Marques Sampaio, Maria Teresa Pedrosa Silva Clerici, Daniela Carlos
Gut dysbiosis is linked to Type 1 diabetes mellitus (T1D). Inulin, a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how inulin affects T1D remains uncertain. Using a streptozotocin-induced (STZ) mouse model, we studied inulin's protective effects. Remarkably, STZ+INU mice resisted T1D, with none developing the disease. They had lower blood glucose, reduced pancreatic inflammation, and normalized serum insulin compared to STZ+SD mice...
November 8, 2023: Journal of Leukocyte Biology