Kohei Okuyama, Kazuhide Inage, Geundong Kim, Tomohito Mukaihata, Ikuko Tajiri, Yasuhiro Shiga, Masahiro Inoue, Yawara Eguchi, Miyako Suzuki-Narita, Takuma Otagiri, Ryuto Tsuchiya, Takahisa Hishiya, Takahito Arai, Noriyasu Toshi, Soichiro Tokeshi, Susumu Tashiro, Shuhei Ohyama, Noritaka Suzuki, Takeo Furuya, Satoshi Maki, Junichi Nakamura, Shigeo Hagiwara, Yuuya Kawarai, Yasuchika Aoki, Toshiaki Kotani, Masao Koda, Hiroshi Takahashi, Tsutomu Akazawa, Seiji Ohtori, Sumihisa Orita
Spinal fixation surgery has been increasingly performed in patients with osteoporosis. Romosozumab, a drug that was introduced in Japan recently, is known to possibly promote bone healing. However, few studies have reported the therapeutic effects of romosozumab in clinical practice in Japan. Therefore, here, we investigated the effects of romosozumab dosage on bone fusion promotion using an ovariectomized rat spinal fusion model. Eight-week-old female Sprague-Dawley rats were matched by body weight and divided into three groups: 1...
April 3, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society