journal
Journals Journal of Orthopaedic Researc...

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society

https://read.qxmd.com/read/38864683/muscle-and-joint-function-in-the-rotator-cuff-deficient-shoulder
#1
JOURNAL ARTICLE
Angus Yeung, Ashen Fernando, Minoo Patel, Laura Gatto, David C Ackland
Full-thickness rotator cuff tears can lead to poor coaptation of the humeral head to the glenoid, disrupting muscle forces required for glenohumeral joint stability, ultimately leading to joint subluxation. The aim of this study was to evaluate muscle forces and glenohumeral joint translations during elevation in the presence of isolated and combined full-thickness rotator cuff tears. Eight fresh-frozen upper limbs were mounted to a computer-controlled testing apparatus that simulated joint motion by simulated muscle force application...
June 12, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38860529/triamcinolone-acetonide-has-minimal-effect-on-short-and-long-term-metabolic-activities-of-cartilage
#2
JOURNAL ARTICLE
Annie Porter, Emily Newcomb, Steven DiStefano, Jacob Poplawski, Jonathan Kim, Michael Axe, Xin Lucas Lu
Intra-articular corticosteroid injections, such as triamcinolone acetonide (TA), are commonly used by clinicians to manage joint synovial inflammation. However, due to conflicting evidence in literature, there is a fear among clinicians that the injections may be harmful to otherwise healthy cartilage in young patients. The purpose of this study was to evaluate the effects of TA on young, healthy chondrocytes. Articular cartilage samples were harvested from bovine knee joints (1-2 months old). In both healthy and inflammatory (interleukin-1β) challenged cartilage, samples were treated with TA at doses ranging from 1 nM to 200 μM...
June 11, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38855962/comprehensive-gene-expression-analysis-using-rna-sequencing-between-male-and-female-patients-with-idiopathic-carpal-tunnel-syndrome
#3
JOURNAL ARTICLE
Yusuke Ogura, Hiroaki Miyoshi, Shiro Yoshida, Fumiko Arakawa, Mai Takeuchi, Kenjiro Nakama, Mitsuhiro Matsuura, Hirofumi Takada, Yoshiaki Yamanaka, Koji Hiraoka, Koichi Ohshima
Idiopathic carpal tunnel syndrome is the most common entrapment neuropathy in hand surgery, and it is characterized by Noninflammatory fibrosis of subsynovial connective tissues. The prevalence and incidence differ between male and female individuals, and the mechanism underlying this difference remains largely unclear. In the present study, we collected subsynovial connective tissues from six male and six female patients diagnosed with idiopathic carpal tunnel syndrome during surgery. We performed a comprehensive gene expression analysis using RNA sequencing to compare the gene expression profiles between male and female patients with idiopathic carpal tunnel syndrome...
June 10, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38850264/computational-modeling-of-revision-total-hip-arthroplasty-involving-acetabular-defects-a-systematic-review
#4
JOURNAL ARTICLE
Daniel Hopkins, Stuart A Callary, L B Solomon, Sarah C Woodford, Peter V S Lee, David C Ackland
Revision total hip arthroplasty (rTHA) involving acetabular defects is a complex procedure associated with lower rates of success than primary THA. Computational modeling has played a key role in surgical planning and prediction of postoperative outcomes following primary THA, but modeling applications in rTHA for acetabular defects remain poorly understood. This study aimed to systematically review the use of computational modeling in acetabular defect classification, implant selection and placement, implant design, and postoperative joint functional performance evaluation following rTHA involving acetabular defects...
June 8, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38824275/beyond-weakness-exploring-intramuscular-fat-and-quadriceps-atrophy-in-aclr-recovery
#5
JOURNAL ARTICLE
McKenzie S White, Augustin C Ogier, Thomas L Chenevert, Elizabeth Zucker, Luke Stoneback, Constance P Michel, Riann M Palmieri-Smith, Lindsey K Lepley
Muscle weakness following anterior cruciate ligament reconstruction (ACLR) increases the risk of posttraumatic osteoarthritis (OA). However, focusing solely on muscle weakness overlooks other aspects like muscle composition, which could hinder strength recovery. Intramuscular fat is a non-contractile element linked to joint degeneration in idiopathic OA, but its role post-ACLR has not been thoroughly investigated. To bridge this gap, we aimed to characterize quadriceps volume and intramuscular fat in participants with ACLR (male/female = 15/9, age = 22...
June 1, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38814158/the-potential-for-hyperbaric-oxygen-therapy-in-acl-reconstruction
#6
LETTER
Nicolas Nadeau, Sean Richards
No abstract text is available yet for this article.
May 30, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38814154/evaluating-pelvic-tilt-using-the-pelvic-antero-posterior-radiographs-a-novel-method
#7
JOURNAL ARTICLE
Yuan Chai, A Mounir Boudali, Ewout S Veltman, John E Farey, William L Walter
Pelvic tilt (PT) is an important parameter for orthopedic surgeries involving hip and spine, typically determined from sagittal pelvic radiographs. However, various challenges can compromise the feasibility of measurement from sagittal imaging, including obscured landmarks, anatomical variations, hardware interference, and limited medical resources. Addressing these challenges and with the aim of reducing radiation exposure to patients, our study developed a novel method to estimate PT from antero-posterior (AP) radiographs, using vertical distances from the pelvic outlet and obturator foramen...
May 30, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38806292/suppression-of-tnf-%C3%AE-activity-by-immobilization-rescues-mkx-expression-and-attenuates-tendon-ossification-in-a-mouse-achilles-tenotomy-model
#8
JOURNAL ARTICLE
Masashi Isaji, Keisuke Horiuchi, Shinya Kondo, Takahiro Nakagawa, Takahiro Ishizaka, Masatoshi Amako, Kazuhiro Chiba
Traumatic heterotopic ossification is a condition in which extraskeletal bone formation occurs in soft tissues after injury. It most commonly occurs in patients who had major orthopedic surgery and in those with severe extremity injuries. The lesion causes local pain and can impair motor function of the affected limb, but there is currently no established prophylaxis or treatment for this condition. In this study, we show that immobilization at an early stage of the inflammatory response after injury can attenuate ossification formation in a murine Achilles tenotomy model...
May 28, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38804115/relative-contribution-of-the-nail-and-plate-to-a-nail-plate-construct-for-comminuted-distal-femoral-fractures
#9
JOURNAL ARTICLE
Charles C Lin, Nicholas Parody, Utkarsh Anil, Kenneth A Egol
The purpose of this study was to assess the biomechanical contributions of the nail and the plate individually to a complete nail-plate construct in the setting of comminuted distal femur fractures. For this biomechanical study, comminuted extra-articular distal femur fractures were created in 24 synthetic osteoporotic femur models. These were then split into three groups: the nail-only group, the plate-only group, and the nail-plate group. After fixation, each specimen underwent sequential axial and torsional loading, and axial and torsional stiffness were calculated and compared...
May 28, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38796746/detection-of-early-metaphyseal-changes-in-a-piglet-model-of-legg-calv%C3%A3-perthes-disease-using-quantitative-mapping-of-mri-relaxation-times
#10
JOURNAL ARTICLE
Erick O Buko, Alexandra R Armstrong, Jennifer C Laine, Ferenc Tóth, Casey P Johnson
Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder characterized by ischemic injury to the epiphysis of the femoral head, but changes to the metaphysis have also been implicated in its pathogenesis. Quantitative magnetic resonance imaging (MRI) relaxation time mapping techniques are potentially useful to detect injury in LCPD, but studies to date have focused on the epiphysis. The purpose of this study was to assess whether T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times can detect early metaphyseal changes in an LCPD piglet model...
May 26, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38796743/duration-of-cefazolin-prophylaxis-did-not-impact-infection-risk-in-a-murine-model-of-joint-arthroplasty
#11
JOURNAL ARTICLE
Melissa J Karau, Diego Alarcon Perico, Serigo F Guarin Perez, Christina Koscianski, Matthew P Abdel, Robin Patel, Nicholas A Bedard
To minimize periprosthetic joint infection (PJI) risk, some clinicians prescribe extended antibiotic prophylaxis (EAP) following total joint arthroplasty (TJA). Given the limited evidence supporting EAP, we sought to evaluate impact of prophylactic antibiotic duration on PJI risk in a murine TJA model. A titanium prosthesis was implanted into the proximal tibia of 89 mice and inoculated with 102 colony forming units (cfu) of Staphylococcus aureus Xen36. Control mice (n = 20) did not receive antibiotics...
May 26, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38796742/age-dependent-decline-of-b3ar-agonist-mediated-activation-of-fap-ucp-1-expression-in-murine-models-of-chronic-rotator-cuff-repair
#12
JOURNAL ARTICLE
Agustin Diaz, Luke Sang, Steven Garcia, Aboubacar Wague, Michael Davies, Alex Youn, Xuhui Liu, Brian T Feeley
Amibegron, a β3-adrenergic receptor (B3AR) agonist, has recently been shown to provide therapeutic effects for chronic rotator cuff (RC) tears by inducing the expression of uncoupling protein 1 (UCP-1), a marker of brown fat, in fibroadipogenic progenitors (FAPs). However, it remains to be seen if these beneficial effects hold true with age and in older, more clinically relevant populations. This study seeks to understand the impacts of aging on the efficacy of amibegron to treat chronic RC tears. Young (4-month-old) and aged (33-month-old) C57BL/6 mice underwent a RC injury procedure with delayed repair (DR)...
May 26, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38779982/effect-of-amniotic-suspension-allograft-in-a-rat-destabilization-of-medial-meniscus-osteoarthritis-model
#13
JOURNAL ARTICLE
Katrina A Harmon, Kelly A Kimmerling, Katie C Mowry
Placental-derived allografts have been of interest as a potential nonsurgical treatment to reduce pain and improve function in knee osteoarthritis (OA). The purpose of this study was to evaluate the effect of single and repeat injection of amniotic suspension allograft (ASA) on pain, function, and cytokine levels using a destabilization of the medial meniscus (DMM) rat model of OA. Post-DMM surgery, animals were treated with a single injection of either ASA, vehicle, or triamcinolone, or repeated injection of either ASA or vehicle...
May 23, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38761143/current-trends-in-the-prevention-of-adhesions-after-zone-2-flexor-tendon-repair
#14
JOURNAL ARTICLE
Chaiyos Vinitpairot, Jasper H N Yik, Dominik R Haudenschild, Robert M Szabo, Christopher O Bayne
Treating flexor tendon injuries within the digital flexor sheath (commonly referred to as palmar hand zone 2) presents both technical and logistical challenges. Success hinges on striking a delicate balance between safeguarding the surgical repair for tendon healing and initiating early rehabilitation to mitigate the formation of tendon adhesions. Adhesions between tendon slips and between tendons and the flexor sheath impede tendon movement, leading to postoperative stiffness and functional impairment. While current approaches to flexor tendon repair prioritize maximizing tendon strength for early mobilization and adhesion prevention, factors such as pain, swelling, and patient compliance may impede postoperative rehabilitation efforts...
May 18, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38751166/hyperbaric-oxygen-therapy-enhances-osteointegration-of-reimplanted-cranial-flap-by-regulating-osteogenesis-angiogenesis-coupling
#15
JOURNAL ARTICLE
Yonghao Pan, Jiawei Li, Jianqun Wu, Chengyu Yang, Siying Wu, Kunhua Yang, Xue Yang, Qian Chen, Guibing Fu, Chao Liu
Craniectomy is a lifesaving procedure to alleviate dangerously high intracranial pressure by removing a bone flap from the calvarium. However, the osteointegration of reimplanted bone flap with the existing bone tissue is still a clinical challenge. Hyperbaric oxygen (HBO) therapy has shown efficacy in promoting bone repair and could be a promising treatment for accelerating postoperative recovery. However, the specific cell types that are responsive to HBO treatment are not well understood. In this study, we created a murine model of craniectomy, with reimplantation of the cranial flap after 1 week...
May 15, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38751161/target-nf-%C3%AE%C2%BAb-p65-for-preventing-posttraumatic-joint-contracture-in-rats
#16
JOURNAL ARTICLE
Lingpeng Kong, Yuqing Liang, Jing Hou, Weiying Zhang, Shichao Jiang
RelA/p65 is as a crucial component of the nuclear factor κB (NF-κB) signaling pathway that has a significant impact on various fibrotic diseases. However, its role in the fibrosis of tissues surrounding the joint after traumatic injury remains unclear. In this study, rats were divided into three groups: non-operated control (NC) group, p65-siRNA treated (siRNA-p65) group, and negative siRNA treated (siRNA-neg) group. Then, 10 μL (10 nmol) of p65-siRNA was injected into the joint of the siRNA-p65 group...
May 15, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38747030/radiomic-features-of-the-medial-meniscus-predicts-incident-destabilizing-meniscal-tears-data-from-the-osteoarthritis-initiative
#17
JOURNAL ARTICLE
Michelle Villagran, Jeffrey B Driban, Bing Lu, James W MacKay, Timothy E McAlindon, Matthew S Harkey
The objective of this study was to determine the optimal meniscal radiomic features to classify people who will develop an incident destabilizing medial meniscal tear. We used magnetic resonance (MR) images from an existing case-control study that includes images from the first 4 years of the Osteoarthritis Initiative (OAI). For this exploratory analysis (n = 215), we limited our study sample to people with (1) intact menisci at the OAI baseline visit, (2) 4-year meniscal status data, and (3) complete meniscal data from each region of interest...
May 15, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38741241/bead-beating-assay-during-synovial-fluid-dna-extraction-improves-real-time-pcr-accuracy-for-periprosthetic-joint-infection
#18
EDITORIAL
Yuta Hieda, Hyonmin Choe, Hiroyuki Ike, Koki Abe, Ken Kumagai, Masanobu Takeyama, Yusuke Kawabata, Naomi Kobayashi, Yutaka Inaba
Polymerase chain reaction (PCR)-based genetic diagnosis is a rapid and sensitive method to diagnose periprosthetic joint infection (PJI). DNA extraction using bead beating is an effective method for collecting bacterial genes in Gram-positive bacteria. We compared the detection accuracy between the conventional and bead-beating DNA extraction assay. The detection rate improved from 86.7% using the conventional method to 95.6% using the bead-beating. Our results suggest that bead-beating during DNA extraction can improve the accuracy of PCR-based genetic diagnosis of PJI...
May 13, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38735861/development-and-validation-of-a-biomechanically-fidelic-surgical-training-knee-model
#19
JOURNAL ARTICLE
Kieran J Bennett, Parham Foroutan, Ella Fairweather, Rami M A Al-Dirini, Sammuel A Sobey, Nick Litchfield, Mark Roe, Karen J Reynolds, John J Costi, Mark Taylor
Knee arthroplasty technique is constantly evolving and the opportunity for surgeons to practice new techniques is currently highly dependent on the availability of cadaveric specimens requiring certified facilities. The high cost, limited supply, and heterogeneity of cadaveric specimens has increased the demand for synthetic training models, which are currently limited by a lack of biomechanical fidelity. Here, we aimed to design, manufacture, and experimentally validate a synthetic knee surgical training model which reproduces the flexion dependent varus-valgus (VV) and anterior-posterior (AP) mechanics of cadaveric knees, while maintaining anatomic accuracy...
May 12, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/38734879/determination-of-the-effect-of-preoperative-knee-joint-function-on-postoperative-quality-of-life-in-patients-with-total-knee-arthroplasty
#20
JOURNAL ARTICLE
Cigdem Kaya, Cigdem Canbolat Seyman, Yılmaz Kaya
Primary total knee arthroplasty (TKA) is one of the most successful procedures for end-stage knee osteoarthritis. To determine the effect of preoperative knee joint function on postoperative quality of life in patients undergoing primary TKA. This descriptive cross-sectional study was conducted with a total of 208 patients in the orthopedics and traumatology clinic. Data were gathered with a personal information form, the Oxford Knee Score (OKS), and the EQ-5D-5L Quality Of Life Scale in the preoperative period, at postoperative 6th week, and at postoperative 3rd month...
May 11, 2024: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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