Giselle Kaneda, Julie L Chan, Chloe M Castaneda, Angela Papalamprou, Julia Sheyn, Oksana Shelest, Dave Huang, Nadine Kluser, Victoria Yu, Gian C Ignacio, Arkadiusz Gertych, Ryu Yoshida, Melodie Metzger, Wafa Tawackoli, Andrea Vernengo, Dmitriy Sheyn
Tendons and ligaments have a poor innate healing capacity, yet account for 50% of musculoskeletal injuries in the US. Full structure and function restoration post-injury remains an unmet clinical need. This study aimed to assess the application of novel 3D printed scaffolds and induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) overexpressing the transcription factor Scleraxis (SCX, iMSCSCX+ ) as a new strategy for tendon defect repair. The polycaprolactone (PCL) scaffolds were fabricated by extrusion through a patterned nozzle or conventional round nozzle...
March 24, 2023: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society