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Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

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https://read.qxmd.com/read/30756421/association-between-lay-perception-of-morbidity-and-appropriateness-of-specialized-health-care-use-in-adolescent-idiopathic-scoliosis
#1
Marie Beauséjour, Lise Goulet, Marjolaine Roy-Beaudry, Guy Grimard, Hubert Labelle
In absence of school scoliosis screening programs (SSSP) in Canada, this study examined the relationships between the lay person's perception of morbidity and the appropriateness of referral in orthopaedics. A cross-sectional study was conducted with all children consecutively referred in orthopaedics for suspected scoliosis. The 831 participants were classified as Appropriate, Late or Inappropriate referrals for the orthopaedic setting. Perceived morbidity was operationalized by: the scoliosis detection originator, the perceptions of the seriousness of the condition and urgency to consult a physician, the perception of the general health, as well as Visible Back Deformity, Self-image and Pain...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30756417/ctgf-induces-tenogenic-differentiation-and-proliferation-of-adipose-derived-stromal-cells
#2
Xiaoning Li, Suphannee Pongkitwitoon, Hongbin Lu, Chang Lee, Richard Gelberman, Stavros Thomopoulos
Intrasynovial tendons are paucicellular and hypovascular, resulting in a poor response to injury. Surgical repair of ruptured or lacerated tendons often lead to complications such as adhesions, repair site gapping, and repair site rupture. Adipose derived stem cells (ASCs) have shown promise for enhancing tendon repair, as they have the capacity to differentiate into tendon fibroblasts and augment the healing response. Furthermore, connective tissue growth factor (CTGF) has been shown to promote tendon regeneration via the stimulation of endogenous tendon stem cells...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30756413/ectopic-spinal-calcification-associated-with-diffuse-idiopathic-skeletal-hyperostosis-dish-a-quantitative-micro-ct-analysis
#3
Dale E Fournier, Chris J D Norley, Steven I Pollmann, Christopher S Bailey, Fahad Al Helal, Katherine E Willmore, David W Holdsworth, Jeffrey Dixon, Cheryle A Séguin
Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory spondyloarthropathy identified radiographically by calcification of the ligaments and/or entheses along the anterolateral aspect of the vertebral column. The etiology and pathogenesis of calcifications are unknown, and the diagnosis of DISH is currently based on radiographic criteria associated with advanced disease. To characterize the features of calcifications associated with DISH, we used micro-computed tomographic imaging to evaluate a cohort of 19 human cadaveric vertebral columns...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30747456/the-dynamic-functional-nucleus-is-a-potential-biomarker-for-structural-degeneration-in-cervical-spine-discs
#4
Clarissa M LeVasseur, Richard Wawrose, Samuel Pitcairn, William F Donaldson, Joon Y Lee, William J Anderst
If intervertebral disc degeneration can be identified early, preventative treatments may be initiated before symptoms become disabling and costly. Changes in disc mechanics, such as the decrease in the compressive modulus of the nucleus, are some of the earliest signs of degeneration. Therefore, in vivo changes in the disc response to compressive load may serve as a biomarker for pending or early disc degeneration. The aim of this study was to assess the potential for using in vivo dynamic disc deformation to identify pathologic structural degeneration of the intervertebral disc...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30747438/increased-pain-and-sensory-hyperinnervation-of-the-ligamentum-flavum-in-patients-with-lumbar-spinal-stenosis
#5
Achim Benditz, Svenja Sprenger, Luise Rauch, Markus Weber, Joachim Grifka, Rainer H Straub
Nociceptive sensory nerve fibers have never been investigated in the ligamentum flavum (LF) of patients with LSS. The aim was to analyze nociceptive sensory nerve fibers in the ligamentum flavum (LF) of patients with LSS. A prospective study in patients with lumbar spinal stenosis (LSS) undergoing invasive surgical treatment for lumbar spinal stenosis (LSS) with flavectomy was performed. Patients with LSS were subjected to flavectomy and density of sensory and sympathetic nerve fibers, macrophages, vessels, activated fibroblasts, and cells were investigated by immunostaining techniques...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30747435/augmentation-of-chronic-rotator-cuff-healing-using-adipose-derived-stem-cell-seeded-human-tendon-derived-hydrogel
#6
Yukitoshi Kaizawa, Austin Franklin, Jacinta Leyden, Anthony W Behn, U Serdar Tulu, Daniel Leon, Zhen Wang, Geoffrey D Abrams, James Chang, Paige M Fox
Rotator cuff (RTC) repair outcomes are unsatisfactory due to the poor healing capacity of the tendon bone interface (TBI). In our preceding study, tendon hydrogel (tHG), which is a type I collagen rich gel derived from human tendons, improved biomechanical properties of the TBI in a rat chronic RTC injury model. Here we investigated whether adipose-derived stem cell (ASC)-seeded tHG injection at the repair site would further improve RTC healing. Rats underwent bilateral supraspinatus tendon detachment. Eight weeks later injured supraspinatus tendons were repaired with one of four treatments...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30737834/depletion-of-cytotoxic-cd8-t-cells-impairs-implant-fixation-in-rat-cancellous-bone
#7
Magnus Bernhardsson, Franciele Dietrich-Zagonel, Love Tätting, Pernilla Eliasson, Per Aspenberg
As cytotoxic (CD8+ ) T cells seem to impair shaft fracture healing, we hypothesized that depletion of CD8+ cells would instead improve healing of cancellous bone. Additionally, we also tested if CD8-depletion would influence the healing of ruptured Achilles tendons. Rats received a single injection of either anti-CD8 antibodies or saline and put through surgery 24 hours later. 3 different surgical interventions were performed as follows: 1) a drill hole in the proximal tibia with microCT (BV/TV) to assess bone formation; 2) a screw in the proximal tibia with mechanical evaluation (pull-out force) to assess fracture healing; 3) Achilles tendon transection with mechanical evaluation (force-at-failure) to assess tendon healing...
February 9, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30737824/bone-morphogenetic-protein-2-promotes-osteosarcoma-growth-by-promoting-epithelial-mesenchymal-transition-emt-through-the-wnt-%C3%AE-catenin-signaling-pathway
#8
Haijun Tian, Tangjun Zhou, Hongfang Chen, Chenshuang Li, Ziyue Jiang, Lifeng Lao, Suzana Assad Kahn, M Eugenia L Duarte, Jie Zhao, Michael D Daubs, Zorica Buser, Elsa J Brochmann, Jeffrey C Wang, Samuel S Murray
The correlation between BMP-2 and osteosarcoma growth has gained increased interest in the recent years, however, there is still no consensus. In this study, we tested the effects of BMP-2 on osteosarcoma cells through both in vitro and in vivo experiments. The effect of BMP-2 on the proliferation, migration and invasion of osteosarcoma cells was tested in vitro. Subcutaneous and intratibial tumor models were used for the in vivo experiments in nude mice. The effects of BMP-2 on EMT of osteosarcoma cells and the Wnt/β-catenin signaling pathway were also tested using a variety of biochemical methods...
February 9, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30737817/antimicrobial-effect-of-anesthetic-eluting-ultra-high-molecular-weight-polyethylene-for-post-arthroplasty-antibacterial-prophylaxis
#9
Dmitry Gil, Scott Grindy, Orhun Muratoglu, Hany Bedair, Ebru Oral
Despite being a relatively safe surgery, total joint replacement is often associated with two major complications - severe post-operative pain and periprosthetic joint infection. Local sustained delivery of therapeutics to the surgical site has a potential to address these complications more effectively than current clinical approaches. Given that several analgesics were shown to possess antibacterial activity, we propose here to use analgesic-loaded ultra-high molecular weight polyethylene (UHMWPE) as a delivery vehicle to provide antimicrobial effect after an arthroplasty...
February 9, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30737811/quantifying-complex-micro-topography-of-degenerated-articular-cartilage-surface-by-contrast-enhanced-micro-computed-tomography-and-parametric-analyses
#10
Tuomo Ylitalo, Mikko A J Finnilä, Harpal K Gahunia, Sakari S Karhula, Heikki Suhonen, Maarit Valkealahti, Petri Lehenkari, Edward Haeggström, Kenneth P H Pritzker, Simo Saarakkala, Heikki J Nieminen
One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro-computed tomography (µCT) method for visualizing AC surface in detail. The present study aims to introduce a µCT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface...
February 9, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30720210/protein-biomarkers-in-serum-and-urine-for-determining-presence-or-absence-of-hip-dysplasia-in-a-canine-model
#11
Carin E Ahner, Aaron M Stoker, Chantelle C Bozynski, Cristi R Cook, Emily Leary, Keiichi Kuroki, Carissa N Cruz, James L Cook
This study compares serum and urine concentrations of relevant protein biomarkers among adult dogs with or without radiographic canine hip dysplasia (CHD). Adult (≥ 2 years of age), client-owned dogs (n = 74) radiographically categorized as having at least "good" hips (n = 49) or having "mild", "moderate", or "severe" hip dysplasia (n = 25) by the Orthopedic Foundation for Animals (OFA). Urine and serum samples were obtained from each dog at a single time-point and processed and analyzed for relevant protein biomarkers...
February 5, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30720208/effects-of-immobilization-angle-on-tendon-healing-after-achilles-rupture-in-a-rat-model
#12
Cody D Hillin, George W Fryhofer, Benjamin R Freedman, Daniel S Choi, Stephanie N Weiss, Julianne Huegel, Louis J Soslowsky
Conservative (non-operative) treatment of Achilles tendon ruptures is a common alternative to operative treatment. Following rupture, ankle immobilization in plantarflexion is thought to aid healing by restoring tendon end-to-end apposition. However, early activity may improve limb function, challenging the role of immobilization position on tendon healing, as it may affect loading across the injury site. This study investigated the effects of ankle immobilization angle in a rat model of Achilles tendon rupture...
February 5, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30720205/effect-of-anatomical-variability-on-stress-shielding-induced-by-short-calcar-guided-stems-automated-finite-element-analysis-of-90-femora
#13
Amelie Sas, Pim Pellikaan, Sjoerd Kolk, Pablo Marty, Thierry Scheerlinck, G Harry van Lenthe
Short stem hip implants are becoming increasingly popular since they preserve bone stock and presumably reduce stress-shielding. However, concerns remain whether they are suitable for a wide range of patients with varying anatomy. The aim of this study was to investigate how femoral anatomy influences stress-shielding induced by a short calcar-guided stem across a set of 90 CT-based femur models. A computational tool was developed that automatically selected the optimal size and position of the stem. Finite element models of the intact and implanted femurs were constructed and subjected to walking loads...
February 5, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30690800/in-vivo-analysis-of-spinopelvic-kinematics-and-peak-head-cup-contact-in-total-hip-arthroplasty-patients-with-lumbar-degenerative-disc-disease
#14
Sakkadech Limmahakhun, Hayden N Box, Paul Arauz, David W Hennessy, Christian Klemt, Young-Min Kwon
Anterior instability after total hip arthroplasty (THA) has been described in patients with thoracolumbar kyphotic deformity. Although compensatory posterior pelvic tilt with subsequent increased functional anteversion has been described as the mechanism, there is a paucity of in-vivo data. The purpose of our study was to compare pelvic tilt, anteversion, inclination, and position of head-cup contact points in patients with lumbar degenerative disc disease (DDD) and a matched patient cohort without DDD. A total of 50 THA, 18 hips with lumbar DDD and 32 hips without DDD, underwent CT imaging for 3D hip reconstruction...
January 28, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30690798/effect-of-interface-mechanical-discontinuities-on-scaffold-cartilage-integration
#15
Supansa Yodmuang, Hongqiang Guo, Caroline Brial, Russell F Warren, Peter A Torzilli, Tony Chen, Suzanne A Maher
A consistent lack of lateral integration between scaffolds and adjacent articular cartilage has been exhibited in vitro and in vivo. Given the mismatch in mechanical properties between scaffolds and articular cartilage, the mechanical discontinuity that occurs at the interface has been implicated as a key factor, but remains inadequately studied. Our objective was to investigate how the mechanical environment within a mechanically loaded scaffold-cartilage construct might affect integration. We hypothesized that the magnitude of the mechanical discontinuity at the scaffold-cartilage interface would be related to decreased integration...
January 28, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30690786/the-importance-of-locking-plate-positioning-in-proximal-humeral-fractures-as-predicted-by-computer-simulations
#16
James W A Fletcher, Markus Windolf, R Geoff Richards, Boyko Gueorguiev, Jan Buschbaum, Peter Varga
Multifragmented proximal humeral fractures frequently require operative fixation. The locking plates commonly used are often placed relative to the greater tuberosity, however no quantitative data exists regarding the effect of positional changes. The aim of the study was to establish the effects from variations in proximal-distal PHILOS humeral plate positioning on predicted fixation failure risk. Twenty-one left-sided low-density virtual humeri models were created with a simulation framework from CT data of elderly donors and osteotomized to mimic an unstable three-part malreduced AO/OTA 11-B3...
January 28, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30690777/effect-of-osteochondral-graft-orientation-in-a-biotribological-test-system
#17
Christoph Bauer, Hakan Göçerler, Eugenia Niculescu-Morzsa, Vivek Jeyakumar, Christoph Stotter, Ivana Tóth, Thomas Klestil, Friedrich Franek, Stefan Nehrer
Autologous osteochondral transplantation (AOT) utilizing autografts is a widely used technique for the treatment of small-to-medium cartilage defects occurring in knee and ankle joints. The application of viable cartilage and bone ensures proper integration, early weight bearing, as well as restoration of biomechanical and biotribological properties. However, alignment of the autografts onto the defect site remains a pivotal aspect of reinstating the properties of the joint towards successful autograft integration...
January 28, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30690776/alignment-differs-between-patellofemoral-osteoarthritis-cases-and-matched-controls-an-upright-3d-mri-study
#18
Erin M Macri, Agnes G d'Entremont, Kay M Crossley, Harvi F Hart, Bruce B Forster, David R Wilson, Charles R Ratzlaff, Charlie H Goldsmith, Karim M Khan
Patellofemoral (PF) osteoarthritis (OA) is a prevalent and clinically important knee OA subgroup. Malalignment may be an important risk factor for PF OA. However, little is known about alignment in PF OA, particularly in an upright, weightbearing environment. Using a vertically-oriented open-bore MR scanner, we evaluated 3D knee alignment in 15 PF OA cases and 15 individually matched asymptomatic controls. We imaged one knee per participant while they stood two-legged at four flexion angles ((0°, 15°, 30°, 45°), and also while they stood one-legged at 30 <remove picture pageno 2° knee flexion...
January 28, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30682222/welcome-to-2019
#19
EDITORIAL
Linda J Sandell
No abstract text is available yet for this article.
January 25, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://read.qxmd.com/read/30680795/three-dimensional-motion-of-the-knee-joint-complex-during-normal-walking-revealed-by-mobile-biplane-x-ray-imaging
#20
Hans A Gray, Shanyuanye Guan, Lucas T Thomeer, Anthony G Schache, Richard de Steiger, Marcus G Pandy
Accurate knowledge of knee kinematics is important for a better understanding of normal joint function and for improving patient outcomes subsequent to joint reconstructive surgery. Limited information is available that accurately describes the relative movements of the bones at the knee in vivo, even for the most common of all activities: walking. We used a mobile X-ray imaging system to measure the three-dimensional motion of the entire knee-joint complex - femur, tibia and patella - when humans walk over ground at their natural speeds...
January 25, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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