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International Journal of Cardiology

K T N Breeman, M Dufva, M J Ploegstra, V Kheyfets, T P Willems, J Wigger, K S Hunter, D D Ivy, R M F Berger, U Truong
BACKGROUND: In pulmonary arterial hypertension (PAH), right ventricular (RV) failure is the main cause of mortality. Non-invasive estimation of ventricular-vascular coupling ratio (VVCR), describing contractile response to afterload, could be a valuable tool for monitoring clinical course in children with PAH. This study aimed to test two hypotheses: VVCR by cardiac magnetic resonance (VVCRCMR ) correlates with conventional VVCR by right heart catheterization (VVCRRHC ) and both correlate with disease severity...
May 10, 2019: International Journal of Cardiology
Maurizio Bertaina, Alessandro Galluzzo, Fabrizio D'Ascenzo, Federico Conrotto, Walter Grosso Marra, Simone Frea, Gianluca Alunni, Gabriele Crimi, Claudio Moretti, Antonio Montefusco, Maurizio D'Amico, Leor Perl, Mauro Rinaldi, Carla Giustetto, Gaetano Maria De Ferrari
The real prognostic impact of MitraClip in patients with significant functional mitral regurgitation (FMR) and left ventricular (LV) dysfunction remains to be elucidated. Two randomized controlled trials (RCTs) with conflicting results have been recently published. We conducted a comprehensive meta-analysis of all RCTs and adjusted observational studies to evaluate the clinical impact of percutaneous mitral valve repair when compared with optimal medical therapy (OMT) alone, in patients with symptomatic FMR and LV dysfunction...
May 10, 2019: International Journal of Cardiology
Marina C Costa, Nuno Cortez-Dias, André Gabriel, João de Sousa, Manuela Fiúza, Javier Gallego, Ângelo Nobre, Fausto J Pinto, Francisco J Enguita
BACKGROUND: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in western countries. The factors governing the progression of AF to a permanent chronic condition are still not well characterized. Among epigenetic factors, non-coding RNAs (ncRNAs) such as miRNAs and lncRNAs have been recently described as important players involved in the AF progression. We hypothesize about the existence of additional regulatory layers in AF involving an intricate cross-talk between different ncRNA species, namely miRNAs and circRNAs for the establishment of a chronic AF condition...
May 8, 2019: International Journal of Cardiology
Nicolas Meneveau
No abstract text is available yet for this article.
May 7, 2019: International Journal of Cardiology
Jerzy Bełtowski
No abstract text is available yet for this article.
May 7, 2019: International Journal of Cardiology
Jacek Bil
No abstract text is available yet for this article.
May 7, 2019: International Journal of Cardiology
George Chalikias, Dimitrios N Tziakas
No abstract text is available yet for this article.
May 7, 2019: International Journal of Cardiology
Dana Dlouha, Jevgenija Vymetalova, Jaroslav A Hubacek, Vera Lanska, Ivan Malek
BACKGROUND: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. MATERIALS AND METHODS: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 ± 11.8 years) and 383 donors (age 38...
May 7, 2019: International Journal of Cardiology
Feng Qian, Ye Zhong, Edward L Hannan
BACKGROUND: Recent studies have reported mixed findings regarding the inverse provider volume-outcome relationship for percutaneous coronary interventions (PCIs). METHODS: We included patients who underwent PCIs in New York during December 2012-November 2015. Using risk-adjusted in-hospital/30-day mortality rate and appropriateness of PCI, we tested for a continuous relationship and a variety of annual PCI volume cut points at hospital and operator levels in investigating volume-outcome relationships...
May 6, 2019: International Journal of Cardiology
Otto Mayer, Jitka Seidlerová, Václava Černá, Alena Kučerová, Jiří Vaněk, Petra Karnosová, Jan Bruthans, Peter Wohlfahrt, Renata Cífková, Martin Pešta, Jan Filipovský
BACKGROUND: Secondary prevention of atherosclerotic vascular diseases represents a cascade of procedures to reduce the risk of future fatal and non-fatal cardiovascular events. We sought to determine whether the expression of selected microRNAs influenced mortality of stable chronic cardiovascular patients. METHODS: The plasma concentrations of five selected microRNAs (miR-1, miR-19, miR-126, miR-133 and miR-223) were quantified in 826 patients (mean age 65.2 years) with stable vascular disease (6-36 months after acute coronary syndrome, coronary revascularization or first-ever ischemic stroke)...
May 6, 2019: International Journal of Cardiology
Michele D'Alto, Werner Budts, Gerhard P Diller, Barbara Mulder, Gabriele Egidy Assenza, Lilia Oreto, Paolo Ciliberti, Pier Paolo Bassareo, Michael A Gatzoulis, Konstantinos Dimopoulos
Gender differences in the outcome of acquired cardiovascular disease are well known, but available literature on the influence of gender in congenital heart disease (CHD) is limited. Registries have provided valuable, albeit at times conflicting data. Higher mortality rates have been reported in older males with CHD, while sudden cardiac death is more prevalent in young males. However, mortality around surgery for CHD is higher in girls compared to boys, likely due to smaller body size. Women are at higher risk of developing pulmonary arterial hypertension, but at lower risk of adverse aortic outcomes, even though they are less likely to receive aortic surgery...
May 4, 2019: International Journal of Cardiology
Marco De Carlo, Luca Testa, Massimo Leoncini, Elisa Nicolini, Ferdinando Varbella, Bernardo Cortese, Flavio Ribichini, Antonio L Bartorelli, Paolo Calabria, Ciro Indolfi, Fabrizio Tomai, Bruno Loi, Dionigi Fischietti, Giuseppe Tarantini, Francesco Bedogni, A Sonia Petronio
BACKGROUND: Large prospective studies on the use of bioresorbable vascular scaffolds (BVS) for diffuse coronary artery disease are lacking. IT DISAPPEARS is a large multicentre prospective registry investigating the short and long-term outcomes of everolimus-eluting BVS in patients with long coronary lesions and/or multivessel coronary artery disease ( NCT02004730). We hereby report the 2-year outcomes of the registry. METHODS: We enrolled 1002 patients with complex lesions undergoing implantation of 2040 BVS with a prespecified technique including predilation, correct sizing, and postdilation with non-compliant balloons...
May 3, 2019: International Journal of Cardiology
Valeria Paradies, Georgios J Vlachojannis, Kees-Jan Royaards, Jochem Wassing, Martin van der Ent, Pieter C Smits
BACKGROUND: Drug eluting stents with biodegradable polymers have been developed to address the risk of very late adverse events. Long-term comparison data between the biodegradable polymer-coated biolimus-eluting stent (BES; Nobori®) and the second-generation durable polymer-coated everolimus-eluting stent (EES; XIENCE V® or XIENCE PRIME® or PROMUS™) in diabetic patients are scarce. METHODS: The COMPARE II trial was an investigator-initiated, multicenter, open-label, randomized, all-comers trial which assigned patients undergoing percutaneous coronary intervention (PCI) in a 2:1 fashion to either BES or EES...
May 3, 2019: International Journal of Cardiology
Jens Spiesshoefer
No abstract text is available yet for this article.
May 3, 2019: International Journal of Cardiology
Wei-Chieh Huang, Hsin-I Teng, Hsiang-Yao Chen, Ching-Ju Wu, Chuan-Tsai Tsai, Chien-Hung Hsueh, Ying-Ying Chen, William K Hau, Tse-Min Lu
BACKGROUND: Impaired bioavailability of endothelium-derived nitric oxide (NO) and endothelial dysfunction may play a pivotal role in the pathogenesis of in-stent restenosis (ISR) after coronary stenting. We aimed to investigate the relation between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and the ISR lesions tissue characteristics assessed by optical coherence tomography (OCT). METHODS AND RESULTS: Forty-five patients with symptomatic ISR lesions (17 bare metal stents, 28 drug-eluting stents, medium implantation duration: 58...
May 3, 2019: International Journal of Cardiology
Serena Del Turco, Giuseppina Basta, Alberto Ranieri De Caterina, Silverio Sbrana, Umberto Paradossi, Alessandro Taddei, Giuseppe Trianni, Marcello Ravani, Cataldo Palmieri, Sergio Berti, Annamaria Mazzone
BACKGROUND: Coronary no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI) is associated with a poor clinical prognosis. Although its pathophysiology is not fully elucidated, a deregulated systemic inflammatory response plays an important role. Specifically, the relationship between age-associated differences in inflammatory markers and either no-reflow or mortality in STEMI patients undergoing primary percutaneous coronary intervention (pPCI) has never been investigated...
May 3, 2019: International Journal of Cardiology
Baojin Chen, Ximing Wang, Weihua Yin, Yang Gao, Zhihui Hou, Yunqiang An, Zhennan Li, Xinshuang Ren, Shuo Zhao, Pritam Das, Bin Lu
BACKGROUND: Identifying disease activity in Takayasu arteritis (TAK) is challenging. This study aimed to investigate the value of quantitative characterization with computed tomography angiography in the assessment of disease activity in patients with TAK. METHODS: We retrospectively analysed the data on 162 aortic CT angiography from 140 TAK patients. Patients were categorized based on disease activity according to the National Institutes of Health criteria into two groups: active disease group (n = 65) and inactive disease group (n = 97)...
May 2, 2019: International Journal of Cardiology
Annina S Vischer, Silvia Castelletti, Petros Syrris, Rachel Bastiaenen, Chris Miles, Deniz Akdis, Kris Denhaerynck, Daniel Jacoby, Ardan M Saguner, Andrew D Krahn, Elijah R Behr, William J McKenna, Antonios Pantazis
AIMS: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart muscle disorder associated with an increased risk of life-threatening arrhythmias in some patients. Risk stratification remains challenging. Therefore, we sought a non-invasive, easily applicable risk score to predict sustained ventricular arrhythmias in these patients. METHODS: Cohort of Patients who fulfilled the 2010 ARVC task force criteria were consecutively recruited...
May 1, 2019: International Journal of Cardiology
Peter G Jørgensen, Morten Schou, Tor Biering-Sørensen, Rasmus Mogelvang, Thomas Fritz-Hansen, Tina Vilsbøll, Peter Rossing, Magnus T Jensen
BACKGROUND: Dyspnea is a common clinical challenge in patients with type 2 diabetes and may be a sign of heart failure (HF). We sought to evaluate the predictive value dyspnea with and without an echocardiographic substrate in patients with type 2 diabetes without known heart disease. METHODS: A total of 724 patients with type 2 diabetes followed at specialized clinics participated in this prospective cohort study. Clinical evaluation, comprehensive echocardiography and follow-up through national registers were performed...
May 1, 2019: International Journal of Cardiology
Peter Nørkjær Laursen, Lene Holmvang, Jacob Lønborg, Lars Køber, Dan E Høfsten, Steffen Helqvist, Peter Clemmensen, Henning Kelbæk, Erik Jørgensen, Jens Flensted Lassen, Frants Pedersen, Thomas Høi-Hansen, Bent Raungaard, Christian Juhl Terkelsen, Lisette Okkels Jensen, Golnaz Sadjadieh, Thomas Engstrøm
AIMS: To assess the impact of sampling bias due to reported as well as unreported exclusion of the target population in a multi-center randomized controlled trial (RCT) of ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: We compared clinical characteristics and mortality between participants in the DANAMI-3 trial to contemporary non-participants with STEMI using unselected registries. A total of 179 DANAMI-3 participants (8%) and 617 contemporary non-participants (22%) had died (Log-Rank: P < 0...
May 1, 2019: International Journal of Cardiology
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