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International Journal of Cardiology | Page 2

Ersan Akkaya, Alexander Berkowitsch, Andreas Rieth, Damir Erkapic, Christian W Hamm, Thomas Neumann, Malte Kuniss
INTRODUCTION: There are no data concerning clinical outcome and left atrial (LA) function after LA roof ablation using a second-generation cryoballoon (CB) for treatment of persistent atrial fibrillation (AF). Here, we report the first follow-up results after pulmonary vein isolation (PVI) plus LA roof ablation with the CB technique in patients with symptomatic persistent AF. METHODS AND RESULTS: We enrolled 107 consecutive patients who underwent CB ablation at our institution with the aim of PVI and bidirectional conduction block across the LA roof...
April 30, 2019: International Journal of Cardiology
Claudia Gulea, Rosita Zakeri, Jennifer K Quint
BACKGROUND: Patients hospitalized for heart failure (HF) are at high risk of readmission. Chronic obstructive pulmonary disease (COPD) is one of the most prevalent comorbidities in this population. However, few data and only small studies describe the impact of COPD on the risk of readmission. METHODS AND RESULTS: Hospitalizations for HF were identified in the 2012 National Readmissions Database. We compared clinical characteristics and the risk of all-cause, cardiovascular (CV) and respiratory-related readmission for patients with and without COPD...
April 30, 2019: International Journal of Cardiology
Yue Xi, Daozhan Yu, Rongze Yang, Qingbin Zhao, Junhong Wang, Hong Zhang, Kun Qian, Zhengrong Shi, Weimin Wang, Robert Brown, Yongxia Li, Zhenjun Tian, Da-Wei Gong
Activation of the apelin receptor, or APJ, by apelin is considered a therapeutic avenue for cardiovascular disease, including heart failure. Recently, a novel endogenous ligand for APJ named Elabela (ELA) has been discovered and is known to possess anti-heart failure activity in animal models. However, the short in vivo half-life of ELA constrains its clinical potential. To extend its half-life in vivo, we attempted to make IgG-Fc-ELA fusion proteins. We found that Fc-ELA-32 fusion proteins are cleaved during protein production, whereas Fc-ELA-21 fusion proteins are expressed intact, so we focused our studies on the latter...
April 30, 2019: International Journal of Cardiology
Patrícia O Guimarães, Eric D Peterson, Susanna R Stevens, Yuliya Lokhnygina, Jennifer B Green, Darren K McGuire, Rury R Holman, Renato D Lopes
BACKGROUND: We investigated the use of different antithrombotic therapies at baseline among patients with a history of atrial fibrillation (AF), type 2 diabetes, and established atherosclerotic cardiovascular disease (ASCVD) enrolled in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS). METHODS: TECOS participants with a history of AF were stratified by CHA2 DS2 -VASc score and their antithrombotic use evaluated. Cox proportional hazards models were employed to explore possible associations between history of AF and prespecified clinical outcomes after adjusting for key baseline characteristics...
April 30, 2019: International Journal of Cardiology
Peter Mitro
No abstract text is available yet for this article.
April 30, 2019: International Journal of Cardiology
Takumi Inami, Masaharu Kataoka, Hanako Kikuchi, Ayumi Goda, Toru Satoh
BACKGROUND: Patients with chronic thromboembolic disease (CTED) have chronic thromboembolic obstructions of the pulmonary arteries with exercise intolerance, but without signs of pulmonary hypertension at rest. We investigated the efficacy of balloon pulmonary angioplasty (BPA) for CTED patients. METHODS: Fifteen CTED patients (4 males, 11 females) who underwent BPA were enrolled. The inclusion criteria were 1) chronic thromboembolic obstructions of the pulmonary artery identified on ventilation-perfusion scans and pulmonary angiography, 2) WHO functional class II or greater, and 3) mean PAP of <25 mmHg as measured by right heart catheterization...
April 30, 2019: International Journal of Cardiology
Tomo Ando, Oluwole Adegbala, Pedro Villablanca, Emmanuel Akintoye, Said Ashraf, Mohamed Shokr, Fayez Siddiqui, Hisato Takagi, Cindy L Grines, Luis Afonso, Alexandros Briasoulis
INTRODUCTION: Whether readmission to non-index hospitals (where the initial procedure was not performed) could result in adverse outcomes and increased utilization of healthcare resources compared with readmission to index hospitals after transcatheter aortic valve replacement (TAVR) remains unclear. METHODS: From January 2012 to September 2015, a nationwide readmission database was queried to identify those who were older than 50 years and had endovascular TAVR, using the International Classification of Disease, 9th Revision, Clinical Modification code 35...
April 30, 2019: International Journal of Cardiology
Thomas L Gentles, Monique W M De Laat
No abstract text is available yet for this article.
April 29, 2019: International Journal of Cardiology
Xiao Meng, Wenjun Li, Jianmin Yang, Kai Zhang, Weidong Qin, Guipeng An, Fei Gao, Ying Wang, Cheng Zhang, Yun Zhang
No abstract text is available yet for this article.
April 29, 2019: International Journal of Cardiology
Attila Kiss, Bruno K Podesser
No abstract text is available yet for this article.
April 29, 2019: International Journal of Cardiology
Rocco Vergallo, Italo Porto, Giovanni Luigi De Maria, Domenico D'Amario, Gianmarco Annibali, Mattia Galli, Stefano Migliaro, Giorgio Buccimazza, Cristina Aurigemma, Antonio Maria Leone, Giampaolo Niccoli, Rajesh Kharbanda, Francesco Burzotta, Bernard D Prendergast, Keith M Channon, Carlo Trani, Adrian P Banning, Filippo Crea
BACKGROUND: Dual quantitative coronary angiography (QCA) has been recently tested for assessment of intracoronary thrombus volume in experimental models. The present study aimed to validate dual QCA in vivo for the assessment of thrombus burden by exploring the correlations between dual QCA-thrombus volume and optical coherence tomography (OCT)-derived indices of thrombotic burden. METHODS AND RESULTS: Fifty-one patients with ACS and angiographic evidence of thrombus undergoing OCT of the culprit lesion before stenting were included...
April 29, 2019: International Journal of Cardiology
Pierluigi Demola, Antonio Crocamo, Laura Ceriello, Andrea Botti, Isabella Cremonini, Paolo Pattoneri, Domenico Corradi, Francesco Visioli, Matteo Goldoni, Giovanna Pelà
BACKGROUND: Ethnicity is an important determinant of athletes' cardiovascular adaptation. Black adolescent and adult athletes exhibit a left ventricular (LV) hypertrophy with a concentric remodelling higher than their Caucasian counterparts. Scant data, however, are available on race-related differences in hemodynamic response of adolescent athletes to exercise and its relation with heart remodelling. We evaluated if race-specific, sport-related structural and electrical remodelling in adolescent athletes of Caucasian and African ethnicity exclusively depends on race itself rather than on different cardiovascular responses to physical exercise...
April 28, 2019: International Journal of Cardiology
Takuya Oikawa, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
BACKGROUND: Although several factors, including heart failure (HF) and inflammation, are known to increase the incidence of cancer, it remains unknown whether HF may increase cancer mortality, especially with a reference to inflammation. METHODS AND RESULTS: We examined 8843 consecutive cardiovascular patients without a prior history of cancer in our CHART-2 Study (mean 68 yrs., female 30.9%). As compared with patients without HF (Stage A/B, N = 4622), those with HF (Stage C/D, N = 4221) were characterized by higher prevalence of diabetes, previous myocardial infarction, atrial fibrillation, and stroke...
April 26, 2019: International Journal of Cardiology
Corina Thomet, Philip Moons, Werner Budts, Julie De Backer, Massimo Chessa, Gerhard Diller, Andreas Eicken, Harald Gabriel, Pastora Gallego, Alessandro Giamberti, Jolien Roos-Hesselink, Lorna Swan, Gary Webb, Markus Schwerzmann
BACKGROUND: Clinical guidelines emphasise the need for specialised adult congenital heart disease (ACHD) programmes. In 2014, the working group on Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC) published recommendations on the organisation of specialised care for ACHD. To appraise the extent to which these recommendations were being implemented throughout Europe, we assessed the number of patients in active follow-up and available staff resources in European ACHD programmes...
April 26, 2019: International Journal of Cardiology
Wenhuan Li, Fangfang Yu, Weiwei Zhu, Weiguo Zhang, Tao Jiang
BACKGROUND: Dual-energy computed tomography (DECT) can differentiate iodine from other materials through the material decomposition technique. The purpose of this study was to compare the diagnostic performance of DECT-derived iodine concentration (mg/ml) with conventional enhancement measurements (HU), in detecting left atrial appendage (LAA) thrombi and differentiating thrombi from circulatory stasis in atrial fibrillation (AF) patients referred for catheter ablation. METHODS: Consecutive patients were prospectively recruited and scanned using a third-generation dual-source CT system in dual-energy mode...
April 26, 2019: International Journal of Cardiology
Vidal Essebag, Ahmed AlTurki, Riccardo Proietti, Jeff S Healey, George A Wells, Atul Verma, Andrew D Krahn, Christopher S Simpson, Felix Ayala-Paredes, Benoit Coutu, Richard Leather, Kamran Ahmad, Satish Toal, John Sapp, Marcio Sturmer, Katherine Kavanagh, Eugene Crystal, Tiago L L Leiria, Colette Seifer, Claus Rinne, David Birnie
BACKGROUND: Anti-platelet therapy is commonly used in patients receiving oral anticoagulation and may increase bleeding risk among patients undergoing cardiac implantable electronic device (CIED) surgery. We sought to determine the proportion of anticoagulated patients who are concomitantly receiving anti-platelet therapy, the associated risk of clinically significant hematoma (CSH), and the proportion of patients in whom anti-platelet usage is guideline-indicated. METHODS: A secondary analysis of the Bridge or Continue Coumadin for Device Surgery Randomized Controlled Trial (BRUISE CONTROL)...
April 26, 2019: International Journal of Cardiology
Spyridon Liosis, Matthias Hochadel, Harald Darius, Steffen Behrens, Harald Mudra, Bernward Lauer, Albrecht Elsässer, Anselm K Gitt, Ralf Zahn, Uwe Zeymer
BACKGROUND: It is known that patients with acute coronary syndromes (ACS) and diabetes mellitus (DM) are at higher risk for in-hospital adverse events. However, we hypothesized that the higher event rate is due to the patients' subgroup with renal failure (RF), a common sequel of DM. METHODS AND RESULTS: We used data of the prospective ALKK-PCI registry including all consecutive percutaneous coronary interventions (PCI) for ACS of 48 hospitals between 2008 and 2013...
April 25, 2019: International Journal of Cardiology
Adriana C Diamantino Soares, Lívia S Araújo Passos, Craig Sable, Andrea Beaton, Victor Teatini Ribeiro, Kenneth J Gollob, Walderez O Dutra, Maria Carmo P Nunes
BACKGROUND: Rheumatic heart disease (RHD) is associated with inflammation that damages cardiac valves, often requiring surgical interventions. The underlying mechanisms involved in the disease progression are not completely understood. This study aimed to evaluate cytokine plasma levels in patients with RHD as possible markers of disease severity. METHODS AND RESULTS: Eighty-nine patients with RHD, age of 41 years ±11.5 years, were prospectively enrolled. RHD severity was defined as valve dysfunction that required invasive intervention, either valve repair or replacement...
April 25, 2019: International Journal of Cardiology
Maurice Beghetti, Monika Brand, Rolf M F Berger, Tilman Humpl, Jeremy G Wheeler, D Dunbar Ivy, Damien Bonnet
BACKGROUND: Composite clinical worsening (cCW) outcomes might allow measurement of disease progression in paediatric pulmonary arterial hypertension (PAH). This TOPP registry analysis investigated three cCW outcomes and their predictive strength for lung transplantation/death. METHODS: Patients ≤17 years with idiopathic/familial PAH or PAH-associated congenital heart disease diagnosed ≤3 months before enrolment were included. cCW outcomes included the following variables at enrolment and/or follow-up: all-cause death, PAH-related hospitalisation, lung transplantation, atrial septostomy (cCW1, 2 and 3), WHO FC deterioration, intravenous/subcutaneous prostanoids initiation, syncope (cCW2,3) and occurrence/worsening of ≥2 PAH symptoms (cCW3)...
April 25, 2019: International Journal of Cardiology
Jurij M Kališnik, Viktor Avbelj, Jon Vratanar, Giuseppe Santarpino, Borut Geršak, Theodor Fischlein, Roman Trobec, Janez Žibert
BACKGROUND: Changes in cardiac autonomic regulation and P-wave characteristics are associated with the occurrence of atrial fibrillation. The purpose of this study was to evaluate whether combined preoperative non-invasive determination of cardiac autonomic regulation and PR interval allows for the identification of patients at risk of new-onset atrial fibrillation after cardiac surgery. METHODS: RR, PR and QT intervals, and linear and non-linear heart rate variability parameters from 20 min high-resolution electrocardiographic recordings were determined one day before surgery in 150 patients on chronic beta blockers undergoing elective coronary artery bypass grafting, aortic valve replacement, or both, electively...
April 25, 2019: International Journal of Cardiology
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