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Behavioural Brain Research

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https://read.qxmd.com/read/31009646/behavioral-profile-of-intermittent-vs-continuous-access-to-a-high-fat-diet-during-adolescence
#1
M Carmen Blanco-Gandía, José Miñarro, Marta Rodríguez-Arias
Over the past few years, the effects of a high-fat diet (HFD) on cognitive functions have been broadly studied as a model of obesity, although no studies have evaluated whether these effects are maintained after the cessation of this diet. In addition, the behavioral effects of having a limited access to an HFD (binge-eating pattern) are mostly unknown, although they dramatically increase the vulnerability to drug use in contrast to having continuous access. Thus, the aim of the present study was to compare the effects of an intermittent versus a continuous exposure to an HFD during adolescence on cognition and anxiety-like behaviors, as well as to study the changes observed after the interruption of this diet...
April 19, 2019: Behavioural Brain Research
https://read.qxmd.com/read/31009645/spatial-t-maze-identifies-cognitive-deficits-in-piglets-1-month-after-hypoxia-ischemia-in-a-model-of-hippocampal-pyramidal-neuron-loss-and-interneuron-attrition
#2
Rashmi Singh, Ewa Kulikowicz, Polan T Santos, Raymond C Koehler, Lee J Martin, Jennifer K Lee
Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations with neuropathologic injury remain underdeveloped and underutilized in large, neonatal HI animal models. We examined whether spatial T-maze and inclined beam tests distinguish cognitive and motor differences between HI and sham piglets and correlate with neuropathologic injury...
April 19, 2019: Behavioural Brain Research
https://read.qxmd.com/read/31005560/responsivity-of-lateral-septum-mpfc-connections-in-alloxan-induced-hyperglycemia
#3
Carlos M Contreras, Ana G Gutiérrez-García, María Luisa Moreno-Cortés
The lateral septal nucleus (LSN) is related to the actions of antidepressants, and the prelimbic cortex (PL) and infralimbic cortex (IL) modulate responses to fear. However, unknown is whether experimental diabetes that is induced by alloxan alters the responsivity of these regions. We used a method in which one forebrain region (LSN) was electrically stimulated while single-unit extracellular recordings were performed in another mPFC region (PL and IL). Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with insulin, (b) healthy animals that received a low dose of insulin that does not produce changes in glycemia, and (c) animals that received long-term treatment with fluoxetine...
April 18, 2019: Behavioural Brain Research
https://read.qxmd.com/read/31005352/corrigendum-to-foxo1-mediated-autophagy-plays-an-important-role-in-the-neuroprotective-effects-of-hydrogen-in-a-rat-model-of-vascular-dementia-behav-brain-res-356-2019-98-106
#4
Xin Jiang, Xiaoli Niu, Qingjun Guo, Yanhong Dong, Jing Xu, Nan Yin, Qi Qianqian, Yanqiu Jia, Liwei Gao, Qihui He, Peiyuan Lv
No abstract text is available yet for this article.
April 18, 2019: Behavioural Brain Research
https://read.qxmd.com/read/31004685/the-effects-of-short-term-and-long-term-environmental-enrichment-on-locomotion-mood-like-behavior-cognition-and-hippocampal-gene-expression
#5
Gaurav Singhal, Julie Morgan, Magdalene C Jawahar, Frances Corrigan, Emily J Jaehne, Catherine Toben, Jimmy Breen, Stephen M Pederson, Anthony J Hannan, Bernhard T Baune
BACKGROUND: Environmental enrichment (EE) has been shown to modulate behavior and hippocampal gene expression; however, the currently available literature does not explain the differential effects that may relate to the duration of EE. AIM: To investigate the differential effects of short- and long-term EE on locomotion, anxiety-, depressive- and cognition-like behaviors, and hippocampal gene expression under physiological conditions. METHODS: We assigned either short-term or long-term intervention with respective controls to healthy C57BL/6 mice (n = 12-16/group)...
April 17, 2019: Behavioural Brain Research
https://read.qxmd.com/read/31004684/tauopathy-in-the-periaqueductal-gray-k%C3%A3-lliker-fuse-nucleus-and-nucleus-retroambiguus-is-not-predicted-by-ultrasonic-vocalization-in-tau-p301l-mice
#6
Pedro Trevizan-Baú, Rishi R Dhingra, Emma L Burrows, Mathias Dutschmann, Davor Stanić
Upper airway and vocalization control areas such as the periaqueductal gray (PAG), kölliker-fuse nucleus (KF) and nucleus retroambiguus (NRA) are prone to developing tauopathy in mice expressing the mutant human tau P301 L protein. Consequently, impaired ultrasonic vocalization (USV) previously identified in tau-P301 L mice at the terminal disease stage of 8-9 months of age, was attributed to the presence of tauopathy in these regions. Our aim was to establish whether the onset of USV disorders manifest prior to the terminal stage, and if USV disorders are predictive of the presence of tauopathy in the PAG, KF and NRA...
April 17, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30998995/age-but-not-severity-of-injury-mediates-decline-in-executive-function-validation-of-the-rodent-touchscreen-paradigm-for-preclinical-models-of-traumatic-brain-injury
#7
Alina Arulsamy, Frances Corrigan, Lyndsey E Collins-Praino
Increasingly, it is being recognised that traumatic brain injury (TBI) is not just an acute event but instead results in ongoing neuronal injury that may lead to chronic impairments in multiple cognitive domains. Of these, deficits in executive function are one of the more common changes reported following TBI, and are a major predictor of well-being, social function and quality of life in individuals with a history of TBI. In order to fully understand the relationship between TBI and executive dysfunction, including brain mechanisms that may account for this, experimental models are clearly needed...
April 15, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30998994/anhedonia-following-mild-traumatic-brain-injury-in-rats-a-behavioral-economic-analysis-of-positive-and-negative-reinforcement
#8
Pelin Avcu, Ashley M Fortress, Jennifer E Fragale, Kevin M Spiegler, Kevin C H Pang
Psychiatric disorders affect nearly 50% of individuals who have experienced a traumatic brain injury (TBI). Anhedonia is a major symptom of numerous psychiatric disorders and is a diagnostic criterion for depression. It has recently been appreciated that reinforcement may be separated into consummatory (hedonic), motivational and decisional components, all of which may be affected differently in disease. Although anhedonia is typically assessed using positive reinforcement, the importance of stress in psychopathology suggests the study of negative reinforcement (removal or avoidance of aversive events) may be equally important...
April 15, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30998993/physical-activity-sustains-memory-retrieval-in-dopamine-depleted-mice-previously-treated-with-l-dopa
#9
D Iggena, C Klein, J Rasińska, M Sparenberg, Y Winter, B Steiner
The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional interventions to sustain cognitive functions in Parkinson's disease. The lifestyle intervention "physical activity" improves adult hippocampal neurogenesis and memory but so far, its impact has not been investigated in rodent models for Parkinson's disease previously treated with the standard therapy...
April 15, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30991086/a-search-for-cortical-correlates-of-trait-impulsivity-in-parkinson%C3%A2-s-disease
#10
Katharina M Kubera, Mike M Schmitgen, Simon Nagel, Klaus Hess, Christian Herweh, Dusan Hirjak, Fabio Sambataro, Robert Christian Wolf
BACKGROUND: Impulsivity is an enduring personality trait that is highly relevant for the development of neuropsychiatric disorders. Although impulse control disorders (ICD) are well-characterized non-motor features in Parkinson's disease (PD), mainly related to medication, little is known about neural correlates reflecting trait aspects of impulsivity in PD patients. Here, we address the question whether motor, attentional and non-planning components, measured by the Barratt Impulsiveness Scale (BIS-11), are distinctly related to cortical thickness and cortical folding abnormalities in PD when compared to age-matched healthy controls (HC)...
April 13, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30986492/investigating-the-reciprocal-relationships-between-locomotor-sensitization-to-ethanol-and-ptsd-like-clusters-in-dba-2j-mice
#11
Thierry Matonda-Ma-Nzuzi, Vincent Didone, Vincent Seutin, Ezio Tirelli, Etienne Quertemont
BACKGROUND: Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are two conditions that co-occur frequently. The mechanistic explanations of this co-morbidity are still unclear. The goal of this study was twofold. First to investigate whether PTSD reduces the threshold for the acquisition of ethanol sensitization in an animal model of PTSD. Then to investigate whether ethanol sensitization modulates the expression of PTSD. METHODS: 152 female inbred DBA/2 J mice were submitted to an inescapable footshock paradigm to induce a PTSD-like condition (PTSDLC) and to a paradigm of locomotor sensitization to ethanol...
April 12, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30986491/spontaneous-and-light-induced-lateralization-of-immediate-early-genes-expression-in-domestic-chicks
#12
Elena Lorenzi, Uwe Mayer, Orsola Rosa-Salva, Anastasia Morandi-Raikova, Giorgio Vallortigara
Exposure of domestic chicks' eggs to light during embryo incubation stimulates asymmetrically the two eye-systems, reaching selectively the right eye (left hemisphere) and inducing asymmetries at the behavioral and neural level. Surprisingly, though, some types of lateralization have been observed also in dark incubated chicks, especially at the behavioral level. Here we investigate the mechanisms subtending the development of lateralization, in the presence and in the absence of embryonic light exposure. We measured the baseline level of expression for the immediate early gene product c-Fos, used as an indicator of the spontaneous level of neural activity and plasticity in four areas of the two hemispheres (preoptic area, septum, hippocampus and intermediate medial mesopallium)...
April 12, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30986490/maternal-manipulation-during-late-gestation-gds-17-20-enhances-ethanol-consumption-and-promotes-changes-and-opioid-mrna-expression-in-infant-rats
#13
Larisa Guttlein, Ana Fabiola Macchione, Karla Hernández Fonseca, Olga Beatriz Haymal, Juan Carlos Molina, Ubach Milagros Méndez, Paula Abate
No abstract text is available yet for this article.
April 12, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30986489/contribution-of-sensorimotor-beta-oscillations-during-value-based-action-selection
#14
Xing-Jie Chen, Meaghan McCarthy, Youngbin Kwak
Choosing a course of daily-life actions requires an accurate assessment of the associated risks and potential rewards. We investigated the neural dynamics of this decision process by analyzing the neural electrical signals acquired from electroencephalography (EEG) during a value-based action-selection task. In particular, we determined whether sensorimotor beta oscillations, traditionally studied in the context of motor control, are also involved in value-based decision making for actions. Additionally, we examined the involvement of this beta signal relative to other neural signals such as the ERP components P2 and P3, which have been previously identified in reward processing and value computations...
April 12, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30981736/disruption-of-latent-inhibition-by-subchronic-phencyclidine-pretreatment-in-rats
#15
Asmaa M Al-Ali, Andrew M J Young
Repeated subchronic treatment with the NMDA-receptor antagonist, phencyclidine, causes behavioural changes in rats, which resemble cognitive and negative symptoms of schizophrenia. However, its effects on behaviours modelling positive symptoms are less clear. This study investigated whether subchronic phencyclidine pretreatment affected latent inhibition: impaired conditioning following repeated preexposure of the to-be-conditioned stimulus. Female Lister-hooded rats were pretreated with phencyclidine or saline twice/day for 5 days, then remained drug-free for 10 days before latent inhibition testing...
April 11, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30981735/sex-differences-in-fear-regulation-and-reward-seeking-behaviors-in-a-fear-safety-reward-discrimination-task
#16
Eliza M Greiner, Iris Müller, Makenzie R Norris, Ka H Ng, Susan Sangha
Reward availability and the potential for danger or safety potently regulate emotion. Despite women being more likely than men to develop emotion dysregulation disorders, there are comparatively few studies investigating fear, safety and reward regulation in females. Here, we show that female Long Evans rats did not suppress conditioned freezing in the presence of a safety cue, nor did they extinguish their freezing response, whereas males did both. Females were also more reward responsive during the reward cue until the first footshock exposure, at which point there were no sex differences in reward seeking to the reward cue...
April 11, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30980851/beneficial-effects-of-r-ketamine-but-not-its-metabolite-2r-6r-hydroxynorketamine-in-the-depression-like-phenotype-inflammatory-bone-markers-and-bone-mineral-density-in-a-chronic-social-defeat-stress-model
#17
Zhongwei Xiong, Yuko Fujita, Kai Zhang, Yaoyu Pu, Lijia Chang, Min Ma, Jincao Chen, Kenji Hashimoto
Inflammatory bone markers may play a role in the antidepressant actions of (R)-ketamine in susceptible mice after chronic social defeat stress (CSDS). In this study, we compared the effects of (R)-ketamine and its final metabolite (2R,6R)-hydroxynorketamine (HNK) in depression-like phenotypes, inflammatory bone markers and bone mineral density (BMD) in CSDS susceptible mice. We measured plasma levels of inflammatory bone markers, which included osteoprotegerin (OPG), receptor activator of nuclear factor κB ligand (RANKL), and osteopontin after behavioral tests...
April 10, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30980850/the-presence-of-elevated-circulating-trimethylamine-n-oxide-exaggerates-postoperative-cognitive-dysfunction-in-aged-rats
#18
Fanqing Meng, Ning Li, Dongliang Li, Bingfeng Song, Liang Li
Surgical trauma can cause brain oxidative stress and neuroinflammation, leading to postoperative cognitive dysfunction (POCD), especially in the elderly. Additionally, the pre-existing risk factors may enhance POCD. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has recently been shown to contribute to the pathogenesis of many diseases by increasing oxidative stress and inflammation in the peripheral tissues. Here we examined whether the presence of elevated circulating TMAO would influence surgery-induced cognitive decline...
April 10, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30978410/affective-profiling-for-anxiety-like-behavior-in-a-rodent-model-of-mtbi
#19
Jonathan K Statz, Stephanie L Ciarlone, Jessica A Goodrich, Richard M McCarron, Peter B Walker, Jacob N Norris, Stephen T Ahlers, Anna E Tschiffely
Mild traumatic brain injury is a common outcome of blast exposure, and current literature indicates high rates of comorbid posttraumatic stress disorder (PTSD) in military personnel. Blast-exposed rats display PTSD-like behavior, suggesting relationships may exist between PTSD and blast exposure. Other studies demonstrate the roles of stathmin and corticosterone associated with fear- and anxiety-like behaviors in rodent models. Furthermore, studies have observed ranges of responses to both physical and psychological trauma in animal populations (Elder 2012, Ritov 2016)...
April 9, 2019: Behavioural Brain Research
https://read.qxmd.com/read/30978409/repeated-bifenthrin-exposure-alters-hippocampal-nurr-1-ache-and-induces-depression-like-behavior-in-adult-rats
#20
Brahim Gargouri, Michèle Bouchard, Soraya Wilke Saliba, Hamadi Fetoui, Bernd L Fiebich
Exposure to insecticides has been associated with depression-like symptoms, especially among occupationally exposed populations, such as farmers. Although the neurotoxicity of pyrethroids such as bifenthrin (BF) is well established, it is still unclear whether exposure to BF may have deleterious effects on the hippocampus and thus behavior. We verified the hypothesis that repeated exposure to BF in a rat model elicits neurochemical and behavioral alterations, the latter of which reflects depression-related symptoms...
April 9, 2019: Behavioural Brain Research
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