journal
https://read.qxmd.com/read/38609021/effort-cost-decision-making-associated-with-negative-symptoms-in-schizophrenia-and-bipolar-disorder
#1
JOURNAL ARTICLE
Serhan Isıklı, Aslıhan Bilge Bektaş, Şule Temel, Murat Atabay, Bilgesu Deniz Arkalı, Başak Bağcı, Adem Bayrakcı, Miriam Sebold, Nabi Zorlu
Motivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients with SCZ and 34 patients with BP were enrolled in the study along with 41 healthy controls (HC). Effort-Expenditure for Rewards Task (EEfRT) was used to measure subjects' effort allocation for monetary rewards...
April 10, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38599251/a-tnf-%C3%AE-inhibitor-abolishes-sepsis-induced-cognitive-impairment-in-mice-by-modulating-acetylcholine-and-nitric-oxide-homeostasis-bdnf-release-and-neuroinflammation
#2
JOURNAL ARTICLE
Mehmet Öz, Hüseyin Erdal
Neurodegenerative disorders have a pathophysiology that heavily involves neuroinflammation. In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at a dose of 10mg/kg a total of 3 times throughout the study. On the last two days of the experiment, 50mg/kg of curcumin was administered orally as a positive control group...
April 8, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38599250/structural-characteristics-of-amygdala-subregions-in-type-2-diabetes-mellitus
#3
JOURNAL ARTICLE
Wenbin Qiu, Xiaomei Yue, Haoming Huang, Limin Ge, Weiye Lu, Zidong Cao, Yawen Rao, Xin Tan, Yan Wang, Jinjian Wu, Yuna Chen, Shijun Qiu, Gang Li
Type 2 diabetes mellitus (T2DM) patients often suffer from depressive symptoms, which seriously affect cooperation in treatment and nursing. The amygdala plays a significant role in depression. This study aims to explore the microstructural alterations of the amygdala in T2DM and to investigate the relationship between the alterations and depressive symptoms. Fifty T2DM and 50 healthy controls were included. Firstly, the volumes of subcortical regions and subregions of amygdala were calculated by FreeSurfer...
April 8, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38599249/biomarker-triterpenoids-of-centella-asiatica-as-potential-antidepressant-agents-combining-in-vivo-and-in-silico-studies
#4
JOURNAL ARTICLE
Zaynab Mando, Huda Mando, Adlin Afzan, Khozirah Shaari, Zurina Hassan, Mohamad Nurul Azmi, Fauziahanim Zakaria
Although there are various treatments available for depression, some patients may experience resistance to treatment or encounter adverse effects. Centella asiatica (C. asiatica) is an ancient medicinal herb used in Ayurvedic medicine for its rejuvenating, neuroprotective and psychoactive properties. This study aims to explore the antidepressant-like effects of the major constituents found in C. asiatica, i.e., asiatic acid, asiaticoside, madecassic acid, and madecassoside at three doses (1.25, 2.5, and 5mg/kg, i...
April 8, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38582412/creatine-supplementation-research-fails-to-support-the-theoretical-basis-for-an-effect-on-cognition-evidence-from-a-systematic-review
#5
REVIEW
Terry McMorris, Beverley J Hale, Beatrice S Pine, Thomas B Williams
Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However, previous narrative reviews have only provided limited support for these claims. This is despite the fact that research has shown that creatine supplementation can induce increased brain concentrations of creatine, albeit to a limited extent. We carried out a systematic review to examine the current state of affairs. The review supported claims that creatine supplementation can increases brain creatine content but also demonstrated somewhat equivocal results for effects on cognition...
April 4, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38582411/task-general-or-specific-the-alertness-modulates-post-error-adjustment
#6
JOURNAL ARTICLE
Na Hu, Quanshan Long, Lijun Wang, Xueping Hu, Xiaoxi Wang, Ruimin Ma, Yuqing Bai, Chen Qian, Antao Chen
Previous studies have shown that alertness is closely related to executive control function, but its impact on components of post-error adjustment is unknown. This study applied the Attentional Networks Test and the Four-choice Flanker task with three response stimulus intervals (RSIs) to explore the correlation between alertness and post-error adjustment. The linear mixed-effects model of alertness and RSI on the post-error processing indicators showed a significant negative correlation between the alertness and post-error slowing (PES) under 200ms RSI and post-error improvement in accuracy (PIA) under 700ms RSI and 1200ms RSI...
April 4, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38582410/the-role-of-the-cholinergic-system-in-the-memory-protecting-effects-of-metformin-in-a-model-of-scopolamine-induced-memory-impairment-in-aged-rats
#7
JOURNAL ARTICLE
Elif Aksoz, Busra Aslan Akyol, Oguzhan Korkut
PURPOSE: As the elderly population grows, the prevalence of dementia is also rapidly increasing worldwide. Metformin, an antidiabetic drug, has been shown to have ameliorative effects on impaired cognitive functions in experimental models. However, studies have generally used young animals. Additionally, although it has a major role in Alzheimer's disease (AD) and memory, literature information about the effects of metformin on the cholinergic system is limited. In this study, we investigated the effects of metformin on memory in a model of scopolamine-induced memory impairment in aged rats...
April 4, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38582409/neural-substrates-of-the-interaction-between-effort-expenditure-reward-decision-making-and-outcome-anticipation
#8
JOURNAL ARTICLE
Ling-Ling Wang, Jiao Wang, Bing-Hui Liu, Donghao Tuo, Simon S Y Lui, Wei-Qing Wan, Jia Huang, Raymond C K Chan
OBJECTIVE: Reward anticipation is important for future decision-making, possibly due to re-evaluation of prior decisions. However, the exact relationship between reward anticipation and prior effort-expenditure decision-making, and its neural substrates are unknown. METHOD: Thirty-three healthy participants underwent fMRI scanning while performing the Effort-based Pleasure Experience Task (E-pet). Participants were required to make effort-expenditure decisions and anticipate the reward...
April 4, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38580200/neurophysiological-analysis-of-disadvantageous-social-inequity-exploring-emotional-behavior-changes-and-c-fos-expression-in-a-male-rat-model
#9
JOURNAL ARTICLE
Yujeong Jeong, Jihyun Noh
Humans and other animals exhibit aversive behavioral and emotional responses to unequal reward distributions compared with their conspecifics. Despite the significance of this phenomenon, experimental animal models designed to investigate social inequity aversion and delve into the underlying neurophysiological mechanisms are limited. In this study, we developed a rat model to determine the effects of socially equal or unequal reward and stress on emotional changes in male rats. During the training session, the rats were trained to escape when a sound cue was presented, and they were assigned to one of the following groups: all escaping rats [advantageous equity (AE)], freely moving rats alongside a restrained rat [advantageous inequity (AI)], all restrained rats [disadvantageous equity (DE)], and a rat restrained in the presence of freely moving companions [disadvantageous inequity (DI)]...
April 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38580199/vulnerable-at-rest-a-resting-state-eeg-study-and-psycho-social-factors-of-young-adult-offspring-of-alcohol-dependent-parents
#10
JOURNAL ARTICLE
Milagros Rubio, Ana Sion, Isabel Domínguez Centeno, Daniel Maldonado Sánchez, Gabriel Rubio, Maartje Luijten, Rosa Jurado Barba
BACKGROUND: Offspring of parents with alcohol use disorder (AUD) are more susceptible to developing AUD, with an estimated heritability of around 50%. Vulnerability to AUD in first-degree relatives is influenced by biological factors, such as spontaneous brain activity, and high-risk psychosocial characteristics. However, existing resting-state EEG studies in AUD offspring have shown inconsistent findings regarding theta, alpha, and beta band frequencies. Additionally, research consistently demonstrates an increased risk of internalizing and externalizing disorders, self-regulation difficulties, and interpersonal issues among AUD offspring...
April 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38580198/berberine-and-hesperidin-prevent-the-memory-consolidation-impairment-induced-by-pentylenotetrazole-in-zebrafish
#11
JOURNAL ARTICLE
Kanandra Taisa Bertoncello, Gabriel Rodrigues, Carla Denise Bonan
This study verified the effects of the natural compounds berberine and hesperidin on seizure development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish. Adult animals were submitted to a training session in the inhibitory avoidance test and, after 10minutes, they received an intraperitoneal injection of 25, 50, or 100mg/kg berberine or 100 or 200mg/kg hesperidin. After 30minutes, the animals were exposed to 7.5mM PTZ for 10minutes. Animals were submitted to the test session 24h after the training session to verify their cognitive performance...
April 3, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38570074/characterisation-of-behaviours-relevant-to-apathy-syndrome-in-the-aged-male-rat
#12
JOURNAL ARTICLE
Megan G Jackson, Stafford L Lightman, Emma S J Robinson
Apathy is a complex psychiatric syndrome characterised by motivational deficit, emotional blunting and cognitive changes. It occurs alongside a broad range of neurological disorders, but also occurs in otherwise healthy ageing. Despite its clinical prevalence, apathy does not yet have a designated treatment strategy. Generation of a translational animal model of apathy syndrome would facilitate the development of novel treatments. Given the multidimensional nature of apathy, a model cannot be achieved with a single behavioural test...
April 1, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38556060/reducing-younger-and-older-adults-spatial-disorientation-during-indoor-outdoor-transitions-effects-of-route-alignment-and-visual-access-on-wayfinding
#13
JOURNAL ARTICLE
Yanling Zuo, Jia Zhou
Getting lost could lead to frustration, anxiety, and even fatal accidents. Previous research primarily focused on disorientation in indoor or outdoor environments separately. The indoor-outdoor transition received little attention, yet it is in this complex transition that individuals often lose their way. Therefore, the effects of indoor-outdoor route alignment, visual access, and age on wayfinding performance and spatial cognition were examined. Twenty older adults (aged 18-25) and twenty young adults (aged 65-82) participated in an experiment through desktop Virtual Reality (VR)...
March 29, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38554850/tenuifolin-improves-learning-and-memory-by-regulating-long-term-potentiation-and-dendritic-structure-of-hippocampal-ca1-area-in-healthy-female-mice-but-not-male-mice
#14
JOURNAL ARTICLE
Heng Kong, Yuan-Yuan Han, Gai-Ling Yang, Kang Li, Lu Yu, Xun-Kai Xie, Guang-Yuan Xia, Peng-Ju Wei, Wan-Rong Zhang, Chu-Hua Li
Polygala tenuifolia Wild is an ancient traditional Chinese medicine. Its main component, tenuifolin (TEN), has been proven to improve cognitive impairment caused by neurodegenerative diseases and ovariectomy. However, there was hardly any pharmacological research about TEN and its potential gender differences. Considering the reduction of TEN on learning and memory dysfunction in ovariectomized animals, therefore, we focused on the impact of TEN in different mice genders in the current study. Spontaneous alternation behavior (SAB), light-dark discrimination, and Morris water maze (MWM) tests were used to evaluate the mice's learning and memory abilities...
March 28, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38552743/gps-tracking-technology-and-re-visiting-the-relationship-between-the-avian-visual-wulst-and-homing-pigeon-navigation
#15
JOURNAL ARTICLE
Sara Cioccarelli, Dimitri Giunchi, Enrica Pollonara, Giovanni Casini, Verner P Bingman, Anna Gagliardo
Within their familiar areas homing pigeons rely on familiar visual landscape features and landmarks for homing. However, the neural basis of visual landmark-based navigation has been so far investigated mainly in relation to the role of the hippocampal formation. The avian visual Wulst is the telencephalic projection field of the thalamofugal pathway that has been suggested to be involved in processing lateral visual inputs that originate from the far visual field. The Wulst is therefore a good candidate for a neural structure participating in the visual control of familiar visual landmark-based navigation...
March 28, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38552745/neonatal-nociceptive-stimulation-results-in-pain-sensitization-reduction-of-hippocampal-5-ht-1a-receptor-and-p-creb-expression-in-adult-female-rats
#16
JOURNAL ARTICLE
Jackeline Malheiros, Cristiane Amaral, Luiz Severino da Silva, Ruth Guinsburg, Luciene Covolan
Painful invasive procedures are often performed on newborns admitted to intensive care units (ICU). The acute and long-term effects caused by these stimuli can be investigated in animal models, such as newborn rats. Previous studies have shown that animals subjected to nociceptive stimuli in the neonatal period show sex-specific behavioral changes such as signs of anxiety or depression. Under the same conditions, neonatal stimuli also provoke an increase in the rate of neurogenesis and cell activation in the hippocampal dentate gyrus...
March 27, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38552744/the-hippocampal-salt-inducible-kinase-2-creb-regulated-transcription-co-activator-1-system-mediates-the-antidepressant-actions-of-paroxetine-in-mice
#17
JOURNAL ARTICLE
Xiang-Ming Cai, Xiao-Yu Sun, Rui Li, Pei-Juan Wang, Jian-Cheng Qi, Yu-Xin Ge, Lei Yang
The hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor (SSRI). Recent studies have indicated that paroxetine also modulates several pharmacological targets other than the 5-HT system...
March 27, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38548024/the-protective-role-of-sesame-oil-against-parkinson-s-like-disease-induced-by-manganese-in-rats
#18
JOURNAL ARTICLE
Wedad S Sarawi, Hala A Attia, Hatun A Alomar, Rawan Alhaidar, Esraa Rihan, Nora Aldurgham, Rehab A Ali
Chronic exposure to manganese (Mn) results in motor dysfunction, biochemical and pathological alterations in the brain. Oxidative stress, inflammation, and dysfunction of dopaminergic and GABAergic systems stimulate activating transcription factor-6 (ATF-6) and protein kinase RNA-like ER kinase (PERK) leading to apoptosis. This study aimed to investigate the protective effect of sesame oil (SO) against Mn-induced neurotoxicity. Rats received 25mg/kg MnCl2 and were concomitantly treated with 2.5, 5, or 8ml/kg of SO for 5 weeks...
March 26, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38531510/age-related-changes-in-species-typical-behaviours-in-the-5xfad-mouse-model-of-alzheimer-s-disease-from-4-16-months-of-age
#19
JOURNAL ARTICLE
Timothy P O'Leary, Richard E Brown
Alzheimer's disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. The 5xFAD mouse model of AD shows age-related impairments in sensory- motor and cognitive function, but little is known about changes in species-typical behaviours that may model activities of daily living in AD patients. Therefore, we examined species-typical behaviours used as indices of exploration (rearing) and compulsivity (grooming) across six tests of anxiety-like behaviour or motor function in female 5xFAD mice from 3-16 months of age...
March 24, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38522596/histamine-and-receptors-in-neuroinflammation-their-roles-on-neurodegenerative-diseases
#20
REVIEW
Zhenyu Zhou, Qi An, Wanying Zhang, Yixin Li, Qihang Zhang, Haijing Yan
Histamine, an auto-reactive substance and mediator of inflammation, is synthesized from histidine through the action of histidine decarboxylase (HDC). It primarily acts on histamine receptors in the central nervous system (CNS). Increasing evidence suggests that histamine and its receptors play a crucial role in neuroinflammation, thereby modulating the pathology of neurodegenerative diseases. Recent studies have demonstrated that histamine regulates the phenotypic switching of microglia and astrocytes, inhibits the production of pro-inflammatory cytokines, and alleviates inflammatory responses...
March 22, 2024: Behavioural Brain Research
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