Osman Sinen, Ayşegül Gemici Sinen, Narin Derin, Mutay Aydın Aslan
Parkinson's Disease is a progressive neurodegenerative disorder characterized by motor symptoms resulting from the loss of nigrostriatal dopaminergic neurons. Kisspeptins (KPs) are a family of neuropeptides that are encoded by the Kiss-1 gene, which exert their physiological effects through interaction with the GPR54 receptor. In the current investigation, we investigated the prospective protective effects of central KP-54 treatments on nigrostriatal dopaminergic neurons and consequent motor performance correlates in 6-hydroxydopamine (6-OHDA)-lesioned rats...
May 2, 2024: Behavioural Brain Research
Na Hu, Quanshan Long, Lijun Wang, Xueping Hu, Xiaoxi Wang, Ruimin Ma, Yuqing Bai, Chen Qian, Antao Chen
No abstract text is available yet for this article.
May 2, 2024: Behavioural Brain Research
Victor A D Holanda, Matheus C Oliveira, Carina I de Oliveira Torres, Clarissa de Almeida Moura, Hindiael Belchior, Edilson D da Silva Junior, Elaine C Gavioli
Tamsulosin is an α1 -adrenoceptor antagonist used to treat benign prostatic hyperplasia. This drug exhibits high affinity for α1A - and α1D -adrenoceptor subtypes, which are also expressed in the brain. While dementia symptoms have been reported after administration of tamsulosin in humans, studies on its effects on the rodent brain are still rare. The present study investigated the effects of tamsulosin (and biperiden, an amnesic drug) on cognitive performance in the object recognition task (ORT)...
April 30, 2024: Behavioural Brain Research
Xiaojuan Yao, Ruiying Chen, Hongting Chen, Anthony Koleske, Xiao Xiao
Abl2/Arg (ABL-related gene) is a member of the Abelson family of nonreceptor tyrosine kinases, known for its role in tumor progression, metastasis, tissue injury responses, inflammation, neural degeneration, and other diseases. In this study, we developed Abl2/Arg knockout (arg-/- ) mice to explore its impact on sensory/motor functions and emotion-related behaviors. Our findings show that arg-/- mice exhibit normal growth and phenotypic characteristics, closely resembling their wild-type (WT) counterparts. Behavioral tests, including the elevated plus maze, marble-burying behavior test, and open field test, indicated pronounced anxiety-like behaviors in arg-/- mice compared to WT mice...
April 30, 2024: Behavioural Brain Research
Xiuping Zhang, Yizhu Wang, Xiaohong Yang, Yufang Yang
This study aims to investigate the brain networks engaged in the comprehension of indirect language, as well as the individual difference in this capacity. Specially, we aim to determine whether the difference is solely influenced by the difference in individuals' default network (DN)/language network or whether it also relies on the networks associated with processing of complex cognitive tasks, particularly the multiple demand network (MDN). Conversational indirectness scale (CIS) scores in the interpretation dimension were used as a behavioral indicator of the indirect comprehension tendency...
April 29, 2024: Behavioural Brain Research
Liang Chen, Zhifeng Yue, Ziyu Liu, Huaqin Liu, Jin Zhang, Fengjiao Zhang, Tao Hu, Jianfeng Fu
The nuclear factor erythroid 2-related factor 2 (Nrf2) signalling pathway represents a crucial intrinsic protective system against oxidative stress and inflammation and plays a significant role in various neurological disorders. However, the effect of Nrf2 signalling on the regulation of cognitive impairment remains unknown. Dexmedetomidine (DEX) has neuroprotective effects and can ameliorate lipopolysaccharide (LPS)-induced cognitive dysfunction. Our objective was to observe whether Nrf2 knockout influences the efficacy of DEX in improving cognitive impairment and to attempt to understand its underlying mechanisms...
April 29, 2024: Behavioural Brain Research
Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkona
Chronic social stress can increase susceptibility to chronic diseases such as depression. One of the most used models to study the physiological mechanisms and behavioral outcomes of this type of stress is chronic defeat stress (CDS) in male mice. OF1 male mice were subjected to a stress period lasting 18 days. During that time, non-stressed animals were housed in groups. The cluster analysis of the behavioral profile displayed during the first social interaction divided subjects into two groups: active/aggressive (AA) and passive/reactive (PR)...
April 28, 2024: Behavioural Brain Research
Jiena Hong, Jiemei Chen, Chao Li, Fei Zhao, Jiantao Zhang, Yilong Shan, Hongmei Wen
Poststroke cognitive impairment (PSCI) is a common complication of stroke, but effective treatments are currently lacking. Repetitive transcranial magnetic stimulation (rTMS) is gradually being applied to treat PSCI, but there is limited evidence of its efficacy. To determine rTMS effects on PSCI, we constructed a transient middle cerebral artery occlusion (tMCAO) rat model. Rats were then grouped by random digital table method: the sham group (n = 10), tMCAO group (n = 10) and rTMS group (n = 10)...
April 27, 2024: Behavioural Brain Research
Melisa Riva Gargiulo, Lourdes María Argibay, Víctor Alejandro Molina, Gastón Diego Calfa, Crhistian Luis Bender
Growing evidence indicates a critical role of astrocytes in learning and memory. However, little is known about the role of basolateral amygdala complex (BLA-C) astrocytes in contextual fear conditioning (CFC), a paradigm relevant to understand and generate treatments for fear- and anxiety-related disorders. To get insights on the involvement of BLA-C astrocytes in fear memory, fluorocitrate (FLC), a reversible astroglial metabolic inhibitor, was applied at critical moments of the memory processing in order to target the acquisition, consolidation, retrieval and reconsolidation process of the fear memory...
April 26, 2024: Behavioural Brain Research
Saúl Sal-Sarria, Isabel López-Taboada, Héctor González-Pardo, Nélida M Conejo
Prolonged consumption of diets high in saturated fat and sugar has been related to obesity and overweight, which in turn are linked to cognitive impairment in both humans and rodents. This has become a current issue, especially in children and adolescents, because these stages are crucial to neurodevelopmental processes and programming of adult behavior. To evaluate the effects of gestational and early exposure to an obesogenic diet, three groups with different dietary patterns were established: high-fat and high-sucrose diet (HFS), standard diet (SD), and a dietary shift from a high-fat, high-sucrose diet to a standard diet after weaning (R)...
April 26, 2024: Behavioural Brain Research
Belle Buzzi, Shakir D AlSharari, David M Walentiny, M Imad Damaj
Nicotine smoking contributes to many preventable disabilities, diseases and deaths. Targeting nicotine reward and withdrawal is a basis for the majority of smoking cessation pharmacotherapies. Due to the emergence of interest in 5-HT2A receptor modulators for numerous psychiatric disorders, we investigated the effect of nelotanserin, a 5-HT2A receptor inverse agonist, on nicotine reward and withdrawal in ICR mice. In nicotine-dependent mice, nelotanserin dose-dependently reduced somatic signs of nicotine withdrawal and thermal hyperalgesia as measured in the hot plate test...
April 25, 2024: Behavioural Brain Research
Masashi Arake, Hiroyuki Ohta, Takashi Nozawa, Yasushi Satoh, Masanori Fujita, Takahiro Nakata, Andrea L Meredith, Nariyoshi Shinomiya, Toshiaki Ishizuka, Yuji Morimoto
This study examined the effect of knockout of KCNMA1 gene, coding for the BK channel, on cognitive and attentional functions in mice, with an aim to better understand its implications for human neurodevelopmental disorders. The study used the 3-choice serial reaction time task (3-CSRTT) to assess the learning performance, attentional abilities, and repetitive behaviors in mice lacking the KCNMA1 gene (KCNMA1-/- ) compared to wild-type (WT) controls. Results showed no significant differences in learning accuracy between the two groups...
April 24, 2024: Behavioural Brain Research
Julia Panato-Da Rosa, Isadora Gava Sandrini, Taise Possamai-Della, Jorge M Aguiar-Geraldo, Maria Luísa Machado-Laureano, Alexandra I Zugno, João Quevedo, Samira S Valvassori
The present study aimed to investigate the effects of paradoxical sleep deprivation (PSD) on behavioral and oxidative stress parameters in the brain and serum of mice submitted to the animal model of hyperglycemia induced by alloxan, mimicking the main symptom of diabetes mellitus (DM). Adults C57BL/6 male and female mice received an injection of alloxan, and ten days later, the animals were submitted to the PSD for 36hr. The animals' behavioral parameters were evaluated in the open-field test. Oxidative stress parameters [Diacetyldichlorofluorescein (DCF), Thiobarbituric acid reactive substances (TBARS), Superoxide dismutase (SOD), and Glutathione] were assessed in the frontal cortex, hippocampus, striatum, and serum...
April 22, 2024: Behavioural Brain Research
Yudai Yoshinaga, Nobuya Sato
Although active touch in rodents arises from the forepaws as well as whiskers, most research on active touch only focuses on whiskers. This results in a paucity of tasks designed to assess the process of active touch with a forepaw. We develop a new experimental task, the Reach-to-Grasp and Tactile Discrimination task (RGTD task), to examine active touch with a forepaw in rodents, particularly changes in processes of active touch during motor skill learning. In the RGTD task, animals are required to (1) extend their forelimb to an object, (2) grasp the object, and (3) manipulate the grasped object with the forelimb...
April 20, 2024: Behavioural Brain Research
René Freichel, Nicolas Zink, Fang Yu Chang, Juan Diego Vera, Holly Truong, Giorgia Michelini, Sandra K Loo, Agatha Lenartowicz
BACKGROUND: Executive functioning deficits are central to established neuropsychological models of ADHD. Oscillatory activity, particularly the alpha rhythm (8-12Hz) has been associated with cognitive impairments in ADHD. However, most studies to date examined such neural mechanisms underlying executive dysfunction in children and adolescents with ADHD, raising the question of whether and to what extent those ADHD-related working memory impairments are still present in adults. To this end, the current study aimed to investigate the role of alpha event-related decreases (ERD) during working memory processes in adults with and without ADHD...
April 18, 2024: Behavioural Brain Research
Baoying Shen, Zhixing Wang, Huijing Yu, Xin Shen, Lin Li, Yi Ru, Chunqi Yang, Guangxu Du, Chengcai Lai, Yue Gao
BACKGROUND: Post-traumatic stress disorder (PTSD) refers to a chronic impairing psychiatric disorder occurring after exposure to the severe traumatic event. Studies have demonstrated that medicinal cannabis oil plays an important role in neuroprotection, but the mechanism by which it exerts anti-PTSD effects remains unclear. METHODS: The chronic complex stress (CCS) simulating the conditions of long voyage stress for 4 weeks was used to establish the PTSD mice model...
April 17, 2024: Behavioural Brain Research
Lidiane Aparecida Fernandes, Tércio Apolinário-Souza, Gabriela Castellano, Beatriz Couto Fortuna, Guilherme Menezes Lage
Left and right-hand exhibit differences in the execution of movements. Particularly, it has been shown that manual goal-directed aiming is more accurate with the right hand than with the left, which has been explained through the shorter time spent by the right hand in the feedback phase (FB). This explanation makes sense for the temporal aspects of the task; however, there is a lack of explanations for the spatial aspects. The present study hypothesizes that the right hand is more associated with the FB, while the left hand is more strongly associated with the pre-programming phase (PP)...
April 17, 2024: Behavioural Brain Research
Christopher P Knapp, Eleni Papadopoulos, Jessica A Loweth, Ramesh Raghupathi, Stan B Floresco, Barry D Waterhouse, Rachel L Navarra
Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior. Little is known regarding the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. The present study characterized the effects of rmTBI on risk/reward decision making behavior and catecholamine transmitter regulatory proteins within the PFC...
April 16, 2024: Behavioural Brain Research
Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi
Excessive gaming can impair both mental and physical health, drawing widespread public and clinical attention, especially among young generations. People are now more exposed to gaming-related content on social media than before, and this exposure may have a significant impact on their behavior. However, the neural mechanisms underlying this effect remain unexplored. Using functional magnetic resonance imaging (fMRI), this study aimed to investigate the neural activity induced by gaming-related content on social media among young adults casually playing online games...
April 15, 2024: Behavioural Brain Research
Valentina S Evsiukova, Ivan E Sorokin, Peter A Kulikov, Alexander V Kulikov
The brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration. In the present study alterations in 5-HT-related behavior in the home tank and the novel tank diving test, as well as 5-HT, 5-HIAA levels, tryptophan hydroxylase (TPH), monoamine oxidase (MAO) activity and the expression of genes encoding TPH, MAO, 5-HT transporter and 5-HT receptors in the brain of 6, 12, 24 and 36 month old zebrafish males and females are investigated...
April 15, 2024: Behavioural Brain Research
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