Tauane Gonçalves Soyer, Raquel Soares Bandeira Câmara, Isabela Amorim Gonçalves Pereira, Fernanda Fonseca Ramos, Marcelo Moreira de Jesus, Fernanda Ludolf, Guilherme de Paula Costa, Daniela Pagliara Lage, Camila Simões de Freitas, Danniele Luciana Vale, Breno Luiz Pimenta, Vívian Tamietti Martins, Alexsandro Sobreira Galdino, Miguel Angel Chávez-Fumagalli, Bruno Mendes Roatt, Grasiele de Sousa Vieira Tavares, Eduardo Antonio Ferraz Coelho
The treatment for visceral leishmaniasis (VL) causes toxicity in patients, entails high cost and/or leads to the emergence of resistant strains. No human vaccine exists, and diagnosis presents problems related to the sensitivity or specificity of the tests. Here, we tested two phage clones, B1 and D11, which were shown to be protective against Leishmania infantum infection in a murine model as immunotherapeutics to treat mice infected with this parasite species. The phages were used alone or with amphotericin B (AmpB), while other mice received saline, AmpB, a wild-type phage (WTP) or WTP/AmpB...
May 2024: Parasite Immunology