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Neurological Research

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https://read.qxmd.com/read/31296147/aav-mediated-sirna-against-trpv1-reduces-nociception-in-a-rat-model-of-bone-cancer-pain
#1
Shuangli Zhang, Jun Zhao, Qinggang Meng
Objective : Bone cancer pain is characterized by moderate to severe ongoing pain that commonly requires the use of opiates. Transient receptor potential vanilloid subfamily member 1 (TRPV1), a new target of the analgesics, activated by heat, protons and capsaicin and the hot component of pepper. However, little is known of the anti-nociceptive effects of TRPV1 in cancer-induced bone pain. RNA interference (RNAi) has proven to be a powerful technique to study the function of genes by producing knock-down phenotypes...
July 11, 2019: Neurological Research
https://read.qxmd.com/read/31280707/brain-volume-dynamics-in-multiple-sclerosis-a-case-control-study
#2
Athina Andravizou, Artemios Artemiadis, Christos Bakirtzis, Vasileios Siokas, Athina-Maria Aloizou, Eleni Peristeri, Eftychia Kapsalaki, Vana Tsimourtou, Georgios M Hadjigeorgiou, Efthimios Dardiotis
Objectives : In this study, we aimed to explore the extent and clinical relevance of brain volume dynamics in relapsing remitting multiple sclerosis (RRMS). Methods : Sixty-three patients with RRMS with a disease duration of about 5 years (36 women, mean age 39.9 ± 9.4 years; mean EDSS1.4 ± 1.2, mean relapse rate 0.98 ± 1.17) and 50 healthy control individuals (24 women, mean age 39.1 ± 10.2 years) were recruited and imaged on a MRI scanner by using post-gadolinium high-resolution3D T1W sequences. Cross-sectional and longitudinal volumetric data were obtained by using SIENA(X) and FIRST software...
July 6, 2019: Neurological Research
https://read.qxmd.com/read/31280704/psychosis-in-adults-with-epilepsy-and-its-relationship-to-demographic-clinical-and-treatment-variables
#3
Sherifa Ahmed Hamed, Fadia Ahmed Attiah
Objectives : Psychiatric symptoms and disorders are commonly reported with epilepsy. This study aimed to determine the prevalence of interictal psychosis (IIP) in adults with epilepsy and its risk predictors. Methods : The study included 710 patients (mean age: 36.40 years; age at onset: 13.58 years; duration of epilepsy: 22.80 years). All underwent neurological and psychiatric interviewing, electroencephalography and brain imaging. Results : IIP was reported in 20.65%, of them 50% had temporal lobe epilepsy with impaired awareness and/or to bilateral tonic clonic, 42...
July 6, 2019: Neurological Research
https://read.qxmd.com/read/31271539/the-effect-of-race-on-the-prognosis-of-the-glioblastoma-patient-a-brief-review
#4
Nitesh P Patel, Kristopher A Lyon, Jason H Huang
Objectives : Glioblastoma is the most common primary malignant brain tumor in adults, and despite decades of intensive research regarding its pathophysiology and treatment, the prognosis for glioblastoma patients remains poor. While many studies have analyzed various factors that may influence survival outcomes, the focus of this brief review is to discuss the influence that apatient's race/ethnicity has on survival. This factor has been investigated in large population-based studies and in smaller institutional analyses, but the prognostic utility of this factor has been inconsistent...
July 4, 2019: Neurological Research
https://read.qxmd.com/read/31266412/effect-of-a-novel-designed-intensive-patient-care-program-on-cognitive-impairment-anxiety-depression-as-well-as-relapse-free-survival-in-acute-ischemic-stroke-patients-a-randomized-controlled-study
#5
Hong-Li Yu, Dong-Xue Cao, Jing Liu
Objective : We aimed to evaluate the influence of a novel designed intensive patient care program (IPCP) on cognitive impairment, anxiety, depression and relapse-free survival (RFS) in acute ischemic stroke (AIS) patients. Methods : Two hundred forty-two AIS patients were consecutively recruited in this randomized controlled study and randomly allocated to IPCP group or control group as 1:1 ratio. Patients received IPCP and conventional treatment in IPCP group, while received usual education, cognitive rehabilitation training and conventional treatment in control group for 12-month intervention...
July 2, 2019: Neurological Research
https://read.qxmd.com/read/31256750/the-lack-of-influence-of-ivs5-91-g-a-polymorphism-of-the-scn1a-gene-on-efficacy-of-lamotrigine-in-patients-with-focal-epilepsy
#6
Ivana Markovic, Natasa Pejanovic-Skobic, Nada Bozina, Ivana Susak Sporis, Davor Sporis, Silvio Basic
Background : IVS5-91G>A (rs3812718) polymorphism of the sodium voltage-gated channel alpha subunit 1 (SCN1A) gene has been associated with inadequate responsiveness to common antiepileptic drugs which act as sodium channel blockers. This study was performed to investigate the effect of IVS5-91G>A (rs3812718) polymorphism on lamotrigine (LTG) efficacy in a cohort of patients with non-lesional focal epilepsy taking LTG as monotherapy. Methods : A total of 100 of patients with non-lesional focal epilepsy on LTG monotherapy was included in this prospective interventional study...
June 30, 2019: Neurological Research
https://read.qxmd.com/read/31238812/comparison-of-sildenafil-fluoxetine-and-its-co-administration-against-chronic-constriction-injury-induced-neuropathic-pain-in-rats-an-influential-additive-effect
#7
Indu Melkani, Bimlesh Kumar, Sakshi Panchal, Sachin Kumar Singh, Amarjeet Singh, Monica Gulati, Sameer Balraj Singh Gill, Jivan Jyoti, Narendra Kumar Pandey, Shubham Kumar, Bhuban Subedi
Current drug treatment available for neuropathic pain (NP) provides meager and partial pain relief due to incomplete efficacy and dose-dependent adverse effect. Hence, combination therapy can provide prolongation in analgesic effect with milder side effects. The present investigation aimed at observing the effects of sildenafil (SD) on Fluoxetine (FLX) in attenuation of chronic constriction injury (CCI) induced NP in rats. CCI was achieved in rats by placing four loose ligations around the sciatic nerve and rats were received respective treatments on SD and FLX till 14 days further behaviors parameters like heat hyperalgesia and allodynia, pin prick and acetone drop test were executed in order to access thermal, mechanical and cold allodynia, respectively, on a predetermined time interval...
June 26, 2019: Neurological Research
https://read.qxmd.com/read/31238803/the-prevalence-of-essential-tremor-in-edirne-and-its-counties-accompanied-comorbid-conditions
#8
Sibel Güler, Ayşe Caylan, F Nesrin Turan, Nezih Dağdeviren
Objective : We aimed to determine the prevalence and risk factors of Essential Tremor (ET) in Edirne and its districts, located in Western Thrace, which is the most western part of Turkey. Methods : In this study, 3008 individuals who could communicate and agreed to participate in the study were evaluated. To obtain the data from the applicants in 30 Family Health Centres in Edirne and its districts, a face-to-face questionnaire that consisted of 37 questions was prepared by the researchers. The questionnaire included general information, questions to evaluate potential concomitant comorbid conditions and questions regarding the symptomatology used in ET diagnosis, as well as questions to evaluate ET severity, was examined with the spiral test...
June 26, 2019: Neurological Research
https://read.qxmd.com/read/31221056/neuroprotective-effects-of-a-smoothened-receptor-agonist-against-postoperative-cognitive-dysfunction-by-promoting-autophagy-in-the-dentate-gyrus-of-aged-rats
#9
Pei-Jun Li, Ying-Qiang Guo, Pei-Yan Ding, Ruo-Bing Liu, Fei Deng, Xiao-Xue Feng, Wen-Jun Yan
Objectives : To investigate the effect of purmorphamine (PUR), a Shh co-receptor Smoothened (Smo) agonist, on postoperative cognitive dysfunction (POCD) rat models. Methods : Eighteen-month-old male Sprague-Dawley rats were subjected to intramedullary fixation of a tibial fracture with 7% chloral hydrate anesthesia to mimic human clinical surgery. PUR was administered via an intraperitoneal injection at a dose of 15mg/kg/day for 3 consecutive days at 6 h after surgery. The aged rats were sacrificed after performing a Morris water maze test 1, 3, and 7 days postoperatively to evaluate the expression of related proteins at the appointed time...
June 20, 2019: Neurological Research
https://read.qxmd.com/read/31221031/comorbid-fibromyalgia-in-migraine-patients-clinical-significance-and-impact-on-daily-life
#10
Halil Onder, Mehmet Hamamci, Murat Alpua, Ersin Kasım Ulusoy
Objective : Herein, we aimed to investigate the impact of FM in migraine patients and the specific features and discriminations of this group of migraineurs with FM according to patients without FM. Methods : 102 consecutive migraine patients among 18-50 years old who accepted to involve in the study were included. All patients were asked to complete the following self-report questionnaires for the assessment of pain-related disability, migraine-related disability, anxiety, depression, sleep disturbance and quality of life...
June 20, 2019: Neurological Research
https://read.qxmd.com/read/31203766/association-between-socioeconomic-status-and-prognosis-after-ischemic-stroke-in-south-china
#11
Siping Wang, Binyan Shen, Lin Wei, Meiting Wu, Juan Wang
Background : Previous studies have conflicting results on the association between socioeconomic status and stroke outcomes. Thus, this study aimed to investigate whether socioeconomic status is associated with the prognosis of ischemic stroke in Guangzhou, South China. Methods : A total of 622 patients with ischemic stroke who were admitted in the neurology department of five general hospitals in Guangzhou from May 2014 to October 2014 were included in the study. Socioeconomic status was measured based on education, income, caregiver, and insurance...
June 17, 2019: Neurological Research
https://read.qxmd.com/read/31203746/alterations-in-protein-expression-patterns-of-spinal-peroxisome-proliferator-activated-receptors-after-spinal-cord-injury
#12
Youngkyung Kim, Kyu-Won Park, Jeonghwa Oh, Junesun Kim, Young Wook Yoon
Objectives : Peroxisome proliferator-activated receptors (PPARs) control wound healing processes in damaged tissues. PPAR agonists have neuroprotective effects in spinal cord injury (SCI); however, isotype-specific roles of PPARs are not well understood. Therefore, we evaluated protein expression changes for three isotypes of PPARs at different time points and locations relative to the epicenter after SCI in rats. Methods : A 10-g rod was dropped on the spinal cord which located at the T10 vertebra of rats from a height of 6...
June 17, 2019: Neurological Research
https://read.qxmd.com/read/31204603/nicotinic-acetylcholine-receptor-subunit-expression-in-the-gastrocnemius-and-in-the-orbicularis-oris-before-and-after-facial-nerve-injury-in-rats
#13
Jing Xu, Yong Huang, Shitong Li, Lianhua Chen, Zhanggang Xue
Objectives : To observe the expression of nicotinic acetylcholine receptor (AChR) subunits in normal orbicularis oris and gastrocnemius muscles and to explore the relationships between the expression of AChR subunits and the severity of facial nerve injury. Methods : Gene and protein expression of AChR subunits in the orbicularis oris and gastrocnemius muscles of male Sprague-Dawley rats was measured by reverse transcription polymerase chain reaction and western blotting, respectively, 1-90 days after graded facial nerve injury...
June 16, 2019: Neurological Research
https://read.qxmd.com/read/31146649/body-mass-index-in-patients-with-multiple-sclerosis-a-meta-analysis
#14
Efthimios Dardiotis, Zisis Tsouris, Paraskevi Aslanidou, Athina-Maria Aloizou, Maria Sokratous, Antonios Provatas, Vasileios Siokas, Georgia Deretzi, Georgios M Hadjigeorgiou
Background : The impact of nutrition and diet on the etiology of Multiple Sclerosis (MS) has been evaluated through a number of studies. Only a limited number reported findings on the association between body mass index (BMI) and MS. We systematically assessed whether BMI differs between MS patients and healthy individuals. Methods : The PubMed database was searched for available studies assessing the relationship between BMI and MS until April 2018. Random effects models were applied for evaluating the association of mean BMI between MS, relapsing-remitting MS (RRMS) patients, females, or males with MS, and their respective healthy control groups...
May 31, 2019: Neurological Research
https://read.qxmd.com/read/31142227/vitamin-d-and-the-nervous-system
#15
Giulia Bivona, Caterina Maria Gambino, Giorgia Iacolino, Marcello Ciaccio
Objective : to summarise the activities that Vitamin D (VD) carries out in the brain and to clarify the potential role of VD in neurological diseases. Methods : a literature research has been performed in Pubmed using the following keywords: 'Vitamin D', 'nervous system', 'brain'. Results : the studies reviewed show that VD contributes to cerebral activity in both embryonic and adult brain, helping the connectivity of neural circuits responsible for locomotor, emotional and reward-dependent behavior. Low VD serum levels have been found in patients affected by Alzheimer Disease, Parkinson Disease, Multiple Sclerosis, Autism Spectrum Disorders, Sleep Disorders and Schizophrenia...
May 30, 2019: Neurological Research
https://read.qxmd.com/read/31142218/time-dependent-effects-of-dantrolene-on-motor-evoked-potentials-in-experimental-spinal-cord-injuries
#16
Adem Aslan, Arda Aydogmus, Mehmet Gazi Boyaci, Mehmet Emin Buyukokuroglu, Korhan Altunbas, Ibrahim Keles, Fevzullah Akyuz
Objectives :Traumatic spinal cord injury (SCI) is a significant clinical problem with numerous secondary complications and perpetual deficits. No potent treatment is currently available to fully repair motor and other neurological functions. We studied the effects of dantrolene (DNT) at different time points, on the motor-evoked potentials (MEPs) and the apoptosis response in spinal cord injury. Methods :The study was conducted on a total of 38 rabbits divided into five main groups.These were group 1 (sham): only laminectomy (n = 6), group 2 (SCI): laminectomy and traumatic SCI (n = 8), group 3 (DNT 0h): just after the SCI, DNT 10 mg/kg I...
May 30, 2019: Neurological Research
https://read.qxmd.com/read/31131734/the-relationship-between-the-carotid-and-coronary-artery-stenosis-a-study-based-on-angiography
#17
Lifeng Wang, Xiaofen He
Objective : Previous studies have demonstrated a strong association between carotid artery stenosis (CAS) and coronary artery stenosis disease (COAS). However, prior evaluated methods are non-invasive examinations. This study was aimed to access the relationship between CAS and COAS by the means of angiography. Methods : This is a single-center, retrospectively reviewed study based on digital subtraction angiography (DSA) of carotid artery and coronary artery angiography (CAG). We collected a total of 231 patients undergoing DSA and CAG at the same-day between June 2013 and May 2015...
May 26, 2019: Neurological Research
https://read.qxmd.com/read/31099309/is-air-pollution-a-potential-cause-of-neuronal-injury
#18
Yu Ji, Christopher Stone, Longfei Guan, Changya Peng, Wei Han
INTRODUCTION: Fine particle pollution, including diesel exhaust particles (DEP), is a well-recognized and significant threat to public health. Cerebrovascular disease has been shown to be among the pathologies produced by fine particle exposure, and is thought to arise in this context through oxidative and inflammatory mechanisms. The manner by which these mechanisms interface with normal cerebral metabolism in their promotion of cerebrovascular pathogenesis, however, remains to be elucidated...
May 17, 2019: Neurological Research
https://read.qxmd.com/read/31092145/neuroinflammation-caused-by-mental-stress-the-effect-of-chronic-restraint-stress-and-acute-repeated-social-defeat-stress-in-mice
#19
Yuequan Zhu, Eric Allen Klomparens, Sichao Guo, Xiaokun Geng
OBJECTIVES: Cerebrovascular disease (CVD) is the leading cause of permanent disability worldwide. Inflammation has been reported to play an important role in the progression of CVD. Neuropsychiatric disorders such as depression are associated with increased incidence of CVD epidemiologically, although the mechanisms underlying this association are not clear. In this study, we assessed the effect of the acute repeated social defeat stress (RSDS) and chronic restraint stress (CRS) on neuroinflammation in mice...
May 16, 2019: Neurological Research
https://read.qxmd.com/read/31092142/application-of-functional-near-infrared-spectroscopy-to-explore-the-neural-mechanism-of-transcranial-direct-current-stimulation-for-post-stroke-depression
#20
Hongyu Li, Ning Zhu, Eric A Klomparens, Shu Xu, Man Wang, Qiang Wang, Jing Wang, Luping Song
OBJECTIVES: We investigated the neural mechanism of transcranial direct current stimulation (tDCS) in the treatment of post-stroke depression (PSD) using functional near-infrared spectroscopy (fNIRS). METHODS: Twenty-six patients with PSD were randomly divided into an experimental group receiving tDCS and a control group receiving sham stimulation. The anode and cathode were placed on the left and right dorsolateral prefrontal cortex (PFC). Patients underwent fNIRS before and after treatment, combined with an emotional face sex judgment task and a '1-back' working memory task to assess reaction times and relative concentration changes of oxyhemoglobin (Oxy-Hb) in the PFC...
May 16, 2019: Neurological Research
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