Hanife Abakay, M Fatih Yetkin, Hanife Doğan, Ayşe Güç, Havva Talay Çalış
OBJECTIVE: To investigate the acute effect of myofascial stretching exercises on spasticity, balance, ambulation status and mobility of posterior chain muscles in multiple sclerosis. METHOD: The study was conducted as a randomised controlled experimental study. The study included a total of 80 individuals diagnosed with multiple sclerosis (MS) with a mean age of 43.5 ± 9.62 years (experimental group) and 41.4 ± 10.4 years (control group)...
July 10, 2024: Neurological Research
Fei Chen, Bing Cheng, Xinqi Xu, Weixing Yan, Qiqi Meng, Jinfeng Liu, Ruiqin Yao, Fuxing Dong, Yaping Liu
OBJECTIVES: This study aims to investigate the role of high-intensity interval training (HIIT) in promoting myelin sheath recovery during the remyelination phase in cuprizone (CPZ)-induced demyelination mice and elucidate the mechanisms involving the Wnt/β-catenin pathway. METHODS: After 5 weeks of a 0.2% CPZ diet to induce demyelination, a 4-week recovery phase with a normal diet was followed by HIIT intervention. Mice body weight was monitored. Morris water maze (MWM) gauged spatial cognition and memory, while the open field test (OFT) assessed anxiety levels...
July 9, 2024: Neurological Research
Beny Rilianto, Ricky Gusanto Kurniawan, Bambang Tri Prasetyo, Pratiwi Raissa Windiani, Kelvin Theandro Gotama, Muhammad Kusdiansah, Abrar Arham
BACKGROUND: The demographic, clinical, and angiographic features of ruptured aneurysms compared to unruptured cerebral aneurysms in Indonesia are still limited. This study aims to determine risk factors for rupture according to clinical patterns and morphological features in the Indonesian population. METHOD: We retrospectively reviewed all cerebral aneurysm registries at the largest comprehensive stroke center in Indonesia from January 2019 to January 2022. We compared demographic and vascular risk factors as well as angiographic features between patients with ruptured and unruptured aneurysms with univariate and multivariate analyses...
July 6, 2024: Neurological Research
Nastaran Raissi-Dehkordi, Bardia Hajikarimloo, Negar Raissi-Dehkordi, Fatemeh Khakpai, Mohammad-Reza Zarrindast
OBJECTIVES: Bupropion is an atypical antidepressant that shows robust efficacy in the regulation of neuropathic pain. Citicoline is a dietary supplement which is used as a neuroprotective agent for central nervous system (CNS) disorders. The probable interaction between bupropion and citicoline on neuropathic pain was assessed in male mice. METHODS: Neuropathic pain was induced by sciatic nerve ligation. Neuropathic pain was examined in nerve-ligated mice using tail-flick and hot-plate tests...
July 3, 2024: Neurological Research
Thomas Eibl, Michael Schrey, Jakob Rossmann, Adrian Liebert, Leonard Ritter, Rüdiger Lange, Hans-Herbert Steiner, Karl-Michael Schebesch
BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) has been established as a preoperative diagnostic procedure in glioma surgery, increasing the extent of resection and preserving functional outcome. nTMS motor mapping for the resection of motor eloquent meningiomas has not been evaluated in a comparative analysis, yet. METHODS: We conducted a retrospective matched-pair analysis for tumor location and size in meningioma patients with tumors located over or close to the primary motor cortex...
July 2, 2024: Neurological Research
Mona Af Nada, Salsabil Abo Al-Azayem, Mona K Moawad
BACKGROUND: Early diagnosis of CH is a cornerstone and it is important to detect causes leading to diagnostic delay. Limited published data exist regarding CH in Egypt, and with no data showing characteristics of CH or causes of diagnostic delay . AIM: To investigate clinical characteristics, for CH and detect causes of diagnostic delay in Egypt. METHODOLOGY: A cross-sectional study was conducted including all patients (age: 18-60 years) with primary headache disorders in Egypt with CH patients consecutively recruited over 1 year...
June 27, 2024: Neurological Research
Yang Wang, Tianlun Zhao, Wei-Chih Chen, Yongsheng Zheng, Weikang Xu, Shuai Huang
BACKGROUND: Spinal cord injury (SCI) lacks therapeutic reagents. miRNAs are responsible for mesenchymal stem cells (MSCs) therapy in spinal cord injury. PURPOSE: To discover the underlying therapeutic miRNA target and its mechanism for the treatment of SCI. METHOD: Two RNA sequence datasets were retrieved from the GEO Datasets database which was accessed on 30 December 2023. The targets of the top 2 ranked miRNAs (miR-540-3p and miR-433-5p) were analyzed using online databases (miRDB, miRMap, TargetScan and STRING database) and both miRNAs were screened by cell counting kit-8 (CCK-8) assay...
June 26, 2024: Neurological Research
Büşra Kalkan Balak, Bahar Anaforoglu
BACKGROUND: Diabetic Peripheral Neuropathy (DPN) disrupts body and movement biomechanics, increases mechanical stress during walking, and predisposes individuals to injuries owing to the repetitive effects of these stresses. AIMS: This study aimed to assess and compare the impact of neuropathy on gait and pelvic kinematics in individuals with DPN. METHODS: This case-control study included two groups: 23 individuals diagnosed with DPN aged between 35-70 and 23 healthy individuals aged-35-70...
June 25, 2024: Neurological Research
Wanchun Zhu, Yiman Shen, Hua Zhao, Yinda Tang, Xuhui Wang, Shiting Li
OBJECTIVE: Known as a major surgical complication, postoperative delirium (POD) has not been well studied in patients with intracranial atherosclerotic stenosis (ICAS). This study aimed to investigate the correlation between perioperative clinical characteristics and the occurrence of POD. METHODS: Patients' demographic characteristics and perioperative testing data were collected. Binary logistic regression was conducted for assessing related risk factors. A nomogram was developed to predict the occurrence of POD after percutaneous transluminal angioplasty and stenting (PTAS) in patients with ICAS...
June 23, 2024: Neurological Research
Jasem Youssef Al-Hashel, Raed Alroughani, Fatemah Alshaf, Hasan Kh Ashkanani, Amr Akl, Ohood AlMutairi, Sawsan Alwazzan, Samar Farouk Ahmed
BACKGROUND: Migraine is a prevalent headache disorder with a significant impact on the quality of life. This study aims to investigate the effectiveness and safety of erenumab, mAb targeting the CGRP receptor, in treating chronic (CM) and episodic (EM) migraine in clinical practice Kuwait, providing region-specific insights to treatment options. METHOD: This was a prospective observational cohort study of patients diagnosed with EM or CM treated with erenumab. The primary outcome of the study was to assess the proportion of patients achieving ≥ 50% reduction in monthly mean migraine days, and several changes including the mean number of monthly migraine days, the frequency of analgesic use, attack severity, AEs, and QoL...
June 23, 2024: Neurological Research
Huimin Fan, Jing Feng, Yuchuan Ding, Pan Gu, Liying Wang, Xiaomeng Chen, Xiaokun Geng
OBJECTIVES: The antisaccades (AS) task is considered a reliable indicator of inhibitory control of eye movements in humans. Achieving good AS performance requires efficient cognitive processes that are sensitive to changes in brain structure. White matter hyperintensities (WMH) can cause subcortical-cortical dysconnectivity, affecting diverse cognitive domains. Thus, the AS task was investigated in patients with WMH in cerebral small vessel disease (CSVD). METHODS: In this retrospective study, 75 participants with WMH, determined by neuroimaging standards for CSVD research, were admitted to the Department of Neurology of Beijing Luhe Hospital, Capital Medical University from January 2021 to December 2022...
June 18, 2024: Neurological Research
Yao Wang, Peng Xu, Ke Wang, Xinchen Ji, Jing Lu, Tianying Chang, Baitong Wang, Dongmei Zhang, Xinzhi Chen, Jian Wang
OBJECTIVE: The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the potential causal link between HZ and ischaemic stroke, including its subtypes. METHODS: For our MR analysis, we identified genetic instrumental variables related to both HZ and stroke by screening two prominent publicly accessible genome-wide association study databases...
June 14, 2024: Neurological Research
Tomoyoshi Kobari, Takashi Murayama, Yumi Ikeda
OBJECTIVES: The association between the amount of physical activity and the brain structure in patients with stroke is unclear. Therefore, this study aimed to evaluate the structural characteristics of the brain in patients with chronic stroke engaging in varying levels of physical activity. METHODS: This study included 10 healthy participants and 10 patients with stroke. Structural images were obtained, and the physical activity of patients with stroke was measured using a triaxial accelerometer...
June 14, 2024: Neurological Research
Fayez Dhafer Alshehri, Fahad Mahmood Okal, Salem K Baeshen, Zeyad G Alharbi, Osama Khojah, Waseem K Alhawsawi, Saeed Alamoudi, Ammar Bahati, Ahmed I Lary
OBJECTIVES: Central nervous system tuberculosis (TB) (CNS-TB) can occur in several forms, including intracranial tuberculoma, tuberculous brain abscess, TB meningitis (TBM), and spinal TB. Early treatment can save lives and prevent severe neurological complications. This study aimed to describe the characteristics and post-treatment outcomes of patients with CNS-TB and identify factors associated with poor outcomes. To the best of our knowledge, this is the largest CNS-TB study till date published in Saudi Arabia...
June 10, 2024: Neurological Research
Ahmad A Abujaber, Yahia Imam, Abdulqadir Nashwan, Ahmed M Own, Naveed Akhtar
BACKGROUND: Stroke is a major cause of death and disability worldwide and presents a significant burden on healthcare systems. This retrospective study aims to analyze the characteristics and outcomes of stroke patients admitted to Hamad General Hospital (HGH) stroke service in Qatar from January 2014 to July 2022. METHODS: The medical records of 15,859 patients admitted during the study period were analyzed. The data collected included patient demographics, stroke types, admission location, procedures performed, mortality rates, and other clinical characteristics...
June 6, 2024: Neurological Research
Ana Luiza Decanini Miranda de Souza, Célia Maria Giacheti, Maria Clara Helena Do Couto, Caio Sérgio Galina Spilla, Nathani Cristina da Silva, Mahara Proença, Luciana Pinato
AIM: To evaluate the prevalence and types of sleep problems and their correlations with melatonin content and behavior in Attention-Deficit Hyperactivity Disorder (ADHD) children. METHOD: Sleep in ADHD children and typically developing children (TD) aged 6-14 was assessed by the Sleep Disorders Scale for Children (SDSC) and actigraphy, salivary melatonin quantified by ELISA, and behavior was analyzed using the Strengths and Difficulties Questionnaire. RESULTS: ADHD children showed a higher frequency of sleep disturbances, higher sleep latency, and lower sleep efficiency than in the TD group...
June 4, 2024: Neurological Research
Samaneh Tayefeh-Gholami, Sama Akbarzadeh, Ali Rajabi, Parisa Najari, Tooraj Ghasemzadeh, MohammadAli HosseinpourFeizi, Reza Safaralizadeh
BACKGROUND: MS (Multiple sclerosis) is a progressive neurologic disorder often appearing in the third decade of life. MS is the most frequent demyelinating disease of the central nervous system. The development of MS is influenced by environmental, genetic, and epigenetic factors. The bulk of the human transcriptome comprises lncRNAs, which play crucial regulatory roles. We aimed to assess the SNHG3 and BCYRN1 lncRNA expression in blood samples from MS patients and how these lncRNAs and disease activity are related...
June 4, 2024: Neurological Research
Nehir Toktas, Neslihan Duruturk, Şükran Güzel, Özlem Yürük, Selin Özen
Transcranial direct current stimulation (tDCS) has been used in various neurological diseases due to its positive effects on cortical excitability. The aim of our study is to examine the effects of tDCS in stroke and 28 patients with stroke were randomly divided into two groups as intervention and control groups. Balance was evaluated with the Timed Up and Go Test and Berg Balance Scale. Walking functions were evaluated using the 10-meter Walk Test and the 6 Minutes Walk Test, lower extremity function was evaluated by Fugl Meyer Lower Extremity Scale, quality of life by Stroke-Specific Quality of Life Scale (SS-QOL)...
June 2, 2024: Neurological Research
Ton Fang, Peter Pacut, Abigail Bose, Yuyao Sun, Jeff Gao, Shravan Sivakumar, Brooke Bloom, Eduardo Inacio Nascimento Andrade, Bianca Trombetta, Mehdi Ghasemi
OBJECTIVES: Amyotrophic Lateral Sclerosis (ALS) diagnosis can take 10-16 months from symptom onset, leading to delays in treatment and patient counselling. We studied the impact of clinical and genetic risk factors on the diagnostic timeline of ALS. METHODS: Baseline characteristics, family history, gene testing, onset location, time from symptom onset to diagnosis, and time from first doctor visit to suspected ALS was collected. We used multiple regression to assess the interaction of these factors on ALS diagnostic timeline...
June 2, 2024: Neurological Research
Armin Karamian, Ali Seifi, Brandon Lucke-Wold
OBJECTIVES: Controlling elevated intracranial pressure following brain injury with hyperosmolar agents is one of the mainstay treatments in traumatic brain injury patients. In this study, we compared the effects of hypertonic saline (HS) and mannitol in reducing increased intracranial pressure. METHODS: A total of 637 patients from 15 studies were included in our meta-analysis. The primary outcomes were mortality, the length of stay in the hospital and ICU, and the Glasgow Outcome Scale at follow-up...
June 2, 2024: Neurological Research
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