Neurological Research

Melina Gattellari, Chris Goumas, Bin Jalaludin, John M Worthington
OBJECTIVES: Epidemiological trends for major causes of death and disability, such as stroke, may be monitored using administrative data to guide public health initiatives and service delivery. METHODS: We calculated admissions rates for ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage between 1 January 2005 and December 31st , 2013 and rates of 30-day mortality and 365-day mortality in 30-day survivors to 31 December 2014 for patients aged 15 years or older from New South Wales, Australia...
May 25, 2020: Neurological Research
Athina Andravizou, Vasileios Siokas, Artemios Artemiadis, Christos Bakirtzis, Athina-Maria Aloizou, Nikolaos Grigoriadis, Mary H Kosmidis, Grigorios Nasios, Lambros Messinis, Georgios Hadjigeorgiou, Efthimios Dardiotis, Eleni Peristeri
Objectives : Cognitive impairment is common in multiple sclerosis, but the brain MRI correlates in relapsing remitting multiple sclerosis remain controversial. The current study aimed to investigate whether cognitive decline can be predicted by global and/or regional brain atrophy. Methods : Sixty-three patients with relapsing remitting multiple sclerosis (36 men, mean age 39.9 ± 9.4 years old, mean EDSS 1.4 ± 1.2, mean disease duration 4.9 ± 4.3 years) and 46 healthy controls (21 men, mean age 37...
May 19, 2020: Neurological Research
Ahmed Esmael, Mohamed Elsherif, Mohamed Abdelsalam, Dalia Sabry, Mohamed Mamdouh, Tamer Belal
Objectives : The purpose of this research is to predict the cognitive impairment and to determine its correlation with retinal thickness, mainly (RFNL and GCIPL) in cases of multiple sclerosis. Methods : 60 multiple sclerosis patients and 30 age and sex-matched healthy controls were included in this study. Cognitive functions were evaluated in all study participants by the Montreal Cognitive Assessment (MoCA). OCT imaging was done to determine the thickness. The correlation between the cognitive domains of MoCA and the thickness of the retinal nerve fiber layers was analyzed by Spearman correlation...
May 6, 2020: Neurological Research
Sibel Ozcan, Ozgur Bulmus, Nazife Ulker, Sinan Canpolat, Ebru Onalan Etem, Sinem Oruc, Ahmet Yardimci, Funda Gülcü Bulmus, Ahmet Ayar, Haluk Kelestimur, Mete Ozcan
Objectives : Opioid analgesics have been used for a long time in the treatment of acute and chronic pain. However, they have many side effects including tolerance development to a significant extent. Agomelatine, an atypical antidepressant, has been demonstrated to be effective in experimental studies on pain. However, the effect of agomelatine on morphine tolerance development and its mechanism of action are unknown. The antinociceptive effects of agomelatine, morphine and their combination were assessed in a mice model for painful diabetic neuropathy...
April 26, 2020: Neurological Research
Dong Eun Jang, Julie Ann Zuñiga
Objective : An investigation of the prevalence of medication persistence and associated factors in order to inform effective strategies for improving medication persistence. Methods : A systematic review of the literature from 2010 to the present was performed, using the PRISMA protocol. Primary and empirical observational studies of adult ischemic stroke or transient ischemic attack patients were included. PubMed, CINAHL, Web of Science, Cochrane Library, and PsycInfo databases were searched using the key terms stroke, ischemic stroke, medication persistence, medication adherence , and patient compliance ...
April 22, 2020: Neurological Research
Hikmet Saçmacı, Gül Ferda Cengiz, Tülin Aktürk
Objective : Migraine is a complex episodic disease manifested by dysfunction of the sympathetic nervous system along with numerous neuropsychiatric symptoms. The aim of this study was to identify the dissociative symptoms with neurobiological similarities in episodic and chronic migraine patients and to evaluate their correlation with migraine frequency and severity of attacks. Methods : The study included 61 episodic, 45 chronic migraine patients diagnosed using the criteria of the International Headache Society and 54 healthy control subjects...
April 15, 2020: Neurological Research
Yifeng Wang, Lu Wang, Tianpeng Hu, Feng Wang, Zhaoli Han, Zhenyu Yin, Xintong Ge, Keliang Xie, Ping Lei
Objective :Traumatic brain injury (TBI) is one of the most serious public health problems in the world. Hydrogen (H2 ), a flammable, colorless, and odorless gas, has been observed to have preventive and therapeutic effects on brain trauma and other neurological disorders, but its exact mechanism has not been fully clarified. Methods : To further study the mechanism underlying the role of hydrogen gas in alleviating BBB damage after TBI, we performed the scratch injury model on cultured brain microvascular endothelial cells (bEnd...
April 15, 2020: Neurological Research
Beibei Liu, Fubo Zhou, Yang Hua, Yumei Liu, Xunming Ji
Objectives : Patients with coronary artery disease (CAD) concomitant with extracranial and intracranial atherosclerotic disease (EICAD) may have an increased risk of stroke and myocardial ischemic events. This study aimed to evaluate the concomitant atherosclerotic lesions in extra- and intracranial arterial beds in patients with CAD. Methods : A total of 1274 patients who underwent coronary angiography due to ischemic heart disease were included. All patients underwent ultrasound screening of the extra- and intracranial arteries before coronary angiography, and the degrees of extracranial carotid artery disease (ECAD) and intracranial cerebral artery disease (ICAD) were recorded...
April 14, 2020: Neurological Research
Ming-Xing Liu, Jun Zhong, Lei Xia, Ning-Ning Dou, Shi-Ting Li
Background : To verify the hypothesis that the nature of trigeminal neuralgia (TN) is an ectopic impulse induced by sodium channel modulated by cytokines, we conducted an animal study using the infraorbital nerve chronic constriction injury (CCI) model in rats. Method : The expression of Nav1.3 or IL-6 in the infraorbital nerve (ION) and trigeminal ganglion (TG) were detected by western blot and immunocytochemistry after administration of antisense oligodeoxynucleotide sequence (AS), IL-6 or Anti-IL-6...
April 13, 2020: Neurological Research
Volkan Solmaz, Özüm Atasoy, Oytun Erbaş
This study aimed to evaluate the memory function in a rat model of fatty liver and to investigate the effects of statins on fatty liver, neuronal inflammation, oxidative stress and memory. In this study, 24 male rats were used and were divided into four groups consisting of 6 animals in each. Of them, 12 rats received liquid diet containing 35% fructose for 8 weeks in order to induce hepatosteatosis, while other animals had a normal nutrition. Group 1 served as controls and had a normal nutrition with no drug treatment...
April 6, 2020: Neurological Research
Akbar Hajizadeh Moghaddam, Hananeh Ahmadnia, Sedigheh Khanjani Jelodar, Mojtaba Ranjbar
Background : In this study, we investigate the neuroprotective effects of Hesperetin (Hst) and Nano-Hst on anxiogenic-like behavior and cerebral antioxidant defenses at transcriptional and enzymatic levels in a streptozotocin (STZ)-induced Alzheimer rat model. Methods : Wistar rats were administrated with Hst and Nano-Hst (10 and 20 mg/kg/d) for three weeks. The elevated plus-maze test assessed anxiogenic-like behavior. After behavioral test, activity and gene expression of catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GRx) enzymes, as well as malondialdehyde (MDA) and glutathione (GSH) levels, were measured in the cerebral cortex...
April 6, 2020: Neurological Research
Jin Zhu, Ya-Peng Zhao, Yu-Qi Zhang
Objectives : FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG). Methods : Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate Kaplan-Meier survival curves and explore the association between FOSL1 expression and overall survival (OS) in TCGA-LGG and subgroups. Results : FOSL1 expression in LGG was ranked first among 21 different cancers...
April 3, 2020: Neurological Research
Marjan Hosseini, Mohsen Parviz, Alireza P Shabanzadeh, Elham Zamani, Parvaneh Mohseni-Moghaddam, Leila Gholami, Shima Mehrabadi
The pathophysiology of neuropathic pain is very complex. It involves several environmental and central mechanisms. In this study, we tried to assess the modulatory effect of (S)-3,4-Dicarboxyphenylglycine (DCPG), a metabotropic glutamate receptor subtype 8 (mGluR8) agonist, in a model of chronic central neuropathic pain in male rats. We used a spinal cord contusion method (T6-T8) for the induction of chronic central neuropathic pain.Male Wistar rats were randomly assigned to 5 equal groups (n = 10 per group)...
April 3, 2020: Neurological Research
Paweł Warmus, Natalia Niedziela, Maciej Huć, Krzysztof Wierzbicki, Monika Adamczyk-Sowa
Aim of the Study : Cardioembolic stroke accounts for approximately 15-25% of ischemic strokes and is characterized by a poor prognosis. Atrial fibrillation (AF) is more commonly diagnosed in the elderly.The aim of the study was the assessment of the manifestations of AF in patients hospitalized due to cerebral stroke, with particular attention paid to newly diagnosed AF. Methods : A retrospective analysis was performed on 998 cerebral stroke patients. The data were analyzed for sex, age, cerebral stroke risk factors, drugs, NIHSS, RANKIN scores and ECG recordings on admission and at discharge...
April 2, 2020: Neurological Research
Cem Ismail Küçükali, Burcu Salman, Hande Yüceer, Canan Ulusoy, Neslihan Abacı, Sema Sırma Ekmekci, Erdem Tüzün, Başar Bilgiç, Haşmet Ayhan Hanağası
Objectives : The ubiquitin/proteasome system is one of the main axes of the pathogenesis of Parkinson's disease (PD). Small ubiquitin-related modifier (SUMO) proteins are involved in many biochemical events including regulation of transcriptional activity, modulation of signal transduction pathways, and response to cellular stress indicating a role for SUMO in the ubiquitin/proteasome system. Methods : In this study, our aim was to examine the prevalence of SUMO gene variants and their clinical associations in PD...
April 2, 2020: Neurological Research
Salar Dolkhani, Alireza Najafpour, Rahim Mohammadi
Purpose : The improvement of techniques using conduits that connects the ends of damaged nerves and guides the growth of nerve fibers between the stumps, including adoption of natural or synthetic materials still is a challenge in peripheral nerve repair. The aim of the present novel study was to fabricate and transplant chitosan-selenium biodegradable nanocomposite conduit on transected sciatic nerve in rat model. Methods : In NORMAL group, the left sciatic nerve was exposed through a gluteal muscle incision and after careful hemostasis skin was closed...
March 29, 2020: Neurological Research
Tao Wu, Yifei Li, Baodong Chen
Background : β-1, 4-galactosyltransferase III (B4GALT3) plays an important role in development tumourigenesis. But its role in human glioblastoma (GBM) is still unknown. Materials and methods : To perform gain-of-function and loss-of-function experiment, we transfected siRNA or vector into GBM cells. CCK-8, EdU staining, transwell, western blot, immunofluorescence staining were applied to perform phenotype and mechanism experiment. GlioVis platform was used to analyze B4GALT3 expression from TCGA datasets...
March 21, 2020: Neurological Research
Li Du, Haoxiao Chang, Yuzhen Wei, Xinghu Zhang, Linlin Yin
Backgroud and purpose : Soluble CD40 ligand (sCD40L) plays an important role in inflammation and autoimmune disorders. There is still a controversy regarding sCD40L in neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS). Herein the aims of this study were to evaluate the levels of sCD40L in patients with NMOSD, MS, and other noninflammatory neurological diseases; to investigate its potential relationship with laboratory parameters, glial fibrillary acidic protein (GFAP), thrombopoietin (TPO) and IL-6; and to address whether serum sCD40L levels in acute attacks of NMOSD patients were decreased after treatment with immunoglobulins, plasma exchange, or methylprednisolone...
March 16, 2020: Neurological Research
Tejashwi Shrestha, Tetsuya Takahashi, Chengyu Li, Masayasu Matsumoto, Hirofumi Maruyama
Objective : Activation of nicotinic acetylcholine receptors (nAChRs) results in neuroprotection via a poorly understood molecular mechanism. In this study, we aimed to investigate the effect of nAChR stimulation with nicotine on the regulation of microRNA (miRNA) expression and identify the molecular pathway involved in neuroprotection. Methods : We conducted miRNA expression profiling using a microarray to identify the miRNAs regulated by nicotine. miR-132-5p expression was validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis...
March 14, 2020: Neurological Research
Katarzyna Kaczmarska, Agnieszka Uryga, Michał M Placek, Leanne Calviello, Magdalena Kasprowicz, Georgios V Varsos, Zofia Czosnyka, Ewa Koźniewska, Tomasz Sierzputowski, Waldemar Koszewski, Marek Czosnyka
Objectives : The critical closing pressure (CrCP) defines arterial blood pressure below which cerebral arteries collapse. It represents a clinically relevant parameter for the estimation of cerebrovascular tone. Although there are few methods to assess CrCP, there is no consensus which of them estimates this parameter most accurately. The aim of present retrospective, experimental study was to compare three methods of CrCP estimation: conventional Aaslid's formula and methods based on the cerebrovascular impedance: the established continuous flow forward (CFF) and a new pulsatile flow forward (PFF) model...
March 13, 2020: Neurological Research
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