Miray Atacan Yaşgüçlükal, Zeynep Ünlütürk
INTRODUCTION: We aimed to investigate the effects of the urban or rural dwelling of patients with epilepsy living in Giresun on their use of health services, quality of life, and self-efficacy. METHODS: In this cross-sectional study, patients with epilepsy who were admitted to the neurology outpatient clinic between January 2022 and August 2022 were evaluated. All the participants were individually interviewed to complete the Epilepsy Self-Efficacy Scale (ESES) and Quality of Life in Epilepsy Inventory (QOLIE-10) questionnaire...
March 15, 2023: Neurological Research
Wei Liu, Xue-Lian Ma, Hong-Qiu Gu, Hao Li, Zi-Xiao Li, Yong-Jun Wang
OBJECTIVES: Our goal was to determine the risk conferred by elevated total homocysteine (tHcy) levels on recurrent stroke and cardiovascular disease (CVD) events after an ischemic stroke (IS), using data from the Chinese Stroke Center Alliance (CSCA). METHODS: The study consisted of 746,854 total participants with IS. Subjects were split into groups as well as quartiles according to tHcy level. Groups included a hyperhomocysteinemia (HHcy) group with tHcy ≥15 μmol/l and a normohomocysteinemia group (nHcy) with tHcy <15 μmol/l...
March 9, 2023: Neurological Research
Ahmet Mert Sayın, Neslihan Duruturk, Birol Balaban, Süleyman Korkusuz
OBJECTIVES: The aim of our study was to evaluate the effect of robot-assisted walking in different modalities on cardiorespiratory responses and energy consumption in subacute stroke patients. METHODS: Our study consisted of 16 individuals between the ages of 18-65 years. Individuals diagnosed with hemiplegia after unilateral ischemic or haemorrhagic stroke constitute the stroke group. Eight subacute stroke individuals were included in the experimental group, and eight healthy individuals were included in the control group...
March 8, 2023: Neurological Research
Zhihui Du, Guoliang Wang, Dan Yan, Fang Yang, Dan Bing
OBJECTIVE: This retrospective cohort study aimed to investigate the association of sleep characteristics measured by the Pittsburgh Sleep Quality Index (PSQI) with the vertigo outcome in vertiginous patients with comorbid cardiometabolic diseases. METHODS: Four hundred and thirteen patients with comorbid cardiometabolic diseases who consecutively visiting vertigo and dizziness clinic were enrolled between October 2018 and January 2020 in a tertiary teaching medical center...
February 26, 2023: Neurological Research
Zeba Khan, Sharique A Ali
BACKGROUND: Neurotoxic disorders account for a significant portion of the diseases that influence the worldwide disease burden. Parkinson's disease is one such disease that is linked with environmental toxin exposure. Isocyanates are a highly reactive industrial intermediate used widely in manufacturing plastic products, paints, etc. This study aims to delineate the neurotoxic potential of isocyanate in Parkinson's cell model-SHSY-5Y cells. METHODOLOGY: SHSY-5Y cells were treated with isocyanate analogue (N succinimidyl N methyl carbamate) in time and dose dependant manner...
February 24, 2023: Neurological Research
Hanife Kocakaya, Bahar Say, Serap Yörübulut, Ufuk Ergün
OBJECTIVE: The main aim of this study was to examine patients with migraine in terms of emotional dysregulation and to evaluate whether the emotion dysregulation is effective on chronicity in migraine. MATERIALS AND METHODS: A total of 85 migraine patients and 61 healthy participants were included in this study. All participants were evaluated using Migraine Disability Scale (MIDAS), Visual Analog Scale (VAS), Depression, Anxiety, and Stress Scale (DASS-21), Difficulties in Emotion Regulation Scale (DERS), Pain Catastrophizing Scale (PCS), and the Discomfort Intolerance Scale (DIS)...
February 22, 2023: Neurological Research
Alessandra Turrini, Carlo Maria De Masi, Carlo Sacco, Camilla Mencarani, Vanni Veronesi, Guido Staffa, Crescenzo Capone
OBJECTIVE: Anatomical abnormalities in the thoracic outlet syndrome are very frequent, but radiological images are not always reliable. Therefore, the different features and abilities of CT angiogram and brachial plexus MRI to detect anatomical abnormalities have been investigated. METHODS: All radiological and surgical records of patients operated for thoracic outlet syndrome between January 2011 and December 2018 were retrospectively analyzed. Considering the CT angiogram and/or brachial plexus MRI reports of the preoperative period, the performance of these investigations was evaluated by calculating the precision (P), sensitivity (Recall) and Hamming loss (L)...
February 15, 2023: Neurological Research
Lufeng Wang, Xiaopeng Zhan, Li Jiang, Guangyu Xu, Yiwen Bao, Junlang Wang, Shaohua Qv, Jie Yang, Dongya Huang
BACKGROUND: There is increasing evidence for the association of trimethylamine-N-oxide (TMAO) with cognitive impairment after minor stroke or transient ischemic attack (TIA). However, how TMAO affects cognitive function in TIA patients has seldom been studied. METHODS: A total of 310 TIA participants were retrospectively collected from our stroke register between January 2020 and July 2021. Plasma TMAO was measured by liquid chromatography‒mass spectrometry at baseline...
February 15, 2023: Neurological Research
Melike Sumeyye Ozen, Ebru Calik-Kutukcu, Yeliz Salci, Ecem Karanfil, Asli Tuncer, Kadriye Armutlu
OBJECTIVE: Multiple sclerosis (MS) causes impairment of respiratory function, trunk control, and functional mobility. The purpose of this study was to investigate the relationship between functional mobility and respiratory function and trunk control in MS patients and to compare the findings with those in healthy individuals. METHODS: Thirty MS patients and 30 healthy subjects were included in this case-control study. All participants were evaluated with a pulmonary function test, maximal inspiratory and expiratory pressure (MIP, MEP), core stability tests, a lumbopelvic stability test (LST), a 2-minute walk test (2MWT), and the Timed Up and Go test (TUG)...
February 13, 2023: Neurological Research
Xiao Li, Xianxin Dong, Xikai Tu, Hailong Huang
OBJECTIVE: According to recent studies, synaptic connections by axons formed can resist stronger mechanical stresses. A large number of nerve tissues with regular growth can be achieved quickly by appropriately managing the pulling pace and force. However, currently there are few studies on the physiological characteristics of stretching growth axons. Until now, there is no mature technology for determining whether the axons can normally transmit neural signals following continuous mechanical stimulation...
February 10, 2023: Neurological Research
Fangqian Wu, Ping Zhang, Guohui Zhou
OBJECTIVE: EGR1 has been implicated in the progression of spinal cord injury (SCI). Nevertheless, its specific mechanism in SCI remains to be investigated. Hence, this study explored the potential mechanism of EGR1 in SCI by focusing on neuron apoptosis. METHODS: H2 O2 was utilized to treat rat neurons-dorsal spinal cord (RN-dsc) for the construction of an in vitro model of SCI. Afterwards, cell survival, apoptosis, and LDH leakage were detected to evaluate the injury degree of H2 O2 -treated RN-dsc...
February 9, 2023: Neurological Research
Ze Ma, Ya Zhang, Chen Zhou, Dong Liu, Shujun Gu, Hui Zuo
OBJECTIVES: Few studies have longitudinally evaluated income and education, and their combined effect on incident of stroke in China. METHODS: The present study was based on a cohort with a baseline survey in China. A total of 15,913 participants were finally included. Hazard ratios (HRs) and their 95% confidence intervals (CIs) were calculated to evaluate the association of income, education, and their combination with stroke risk by Cox proportional hazard model...
February 6, 2023: Neurological Research
Luping Zhang, Wenjing Yu, Zhengxiang Zhang, Maosheng Xu, Feng Cui, Wenwen Song, Zhijian Cao
BACKGROUND: Migraine is commonly seen as a cyclic disorder with variable cortical excitability at different phases. Herein, we investigated the cortical excitability in migraine without aura patients during an attack (MWoA-DA) and interictal period (MWoA-DI) and further explored the functional connectivity (FC) in brain regions with cortical excitability abnormalities in patients. METHODS: Seven MWoA-DA patients, twenty-seven MWoA-DI patients, and twenty-nine healthy controls (HC) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan...
January 24, 2023: Neurological Research
Xue Liu, Ya-Nan Ou, Ya-Hui Ma, Liang-Yu Huang, Wei Zhang, Lan Tan
BACKGROUND: Observational studies showed renal function had associations with Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (LBD) and multiple sclerosis (MS). However, it is unknown whether these associations are causal. METHODS: We use a two-sample Mendelian randomization (MR) analysis to investigate causal relationships between renal function and 6 neurodegenerative diseases (NDDs): AD (including familial AD), PD, LBD, frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and MS...
January 24, 2023: Neurological Research
Alessandra Turrini, Guido Staffa, Giulio Rossi, Crescenzo Capone
OBJECTIVES: Peripheral nerve glomus tumors are extremely rare and occur with typical symptoms of peripheral neuropathic pain. Clinicians hardly consider this entity when faced with the swelling of a peripheral nerve and the diagnosis is reached only with histological examination. Nerves of limbs are usually affected and the solid glomus tumor is the most frequent histological variant. CASE DESCRIPTION: A 55-year-old man presented with a glomus tumor of the anterior supraclavicular nerve of the left cervical plexus, misdiagnosed clinically and radiologically as neuroma...
January 22, 2023: Neurological Research
ZengGang Wei, Yong Zhang, JianPing Hou
BACKGROUND: The treatment of neurogenic bladder (NB) is a challenge because conventional therapy often fails. Sacral neuromodulation (SNM) is a minimally invasive technique and an unconventional treatment for neurogenic bladder. Its research is still in the exploratory stage. The research on its effectiveness and safety is not clear. OBJECTIVE: To assess the effectiveness and safety of sacral neuromodulation (SNM) for neurogenic bladder (NB). METHODS: By searching the PubMed databases and Cochrane Library databases, combined with the method of literature tracing, the clinical researches and works on neurogenic bladder and sacral neuromodulation therapy were collected...
January 22, 2023: Neurological Research
Yan Feng, Jiadong Lang, Boyu Sun, Zhongjie Yan, Zongmao Zhao, Guozhu Sun
BACKGROUND: Our present study evaluated the neuroprotection effects of atorvastatin by inhibiting TBI-induced ER stress, as well as the potential role of the Nrf2/HO-1 pathway in experimental TBI. METHODS: First, the mice were divided into four groups:sham, TBI, TBI+Vehicle and TBI+atorvastatin groups. The mice received atorvastatin (10 mg/kg/day) through intragastric gavage once a day for 3 days before TBI. In addition, Nrf2 WT and Nrf2 knockout mice were randomly divided into four groups: Nrf2+/+ TBI, Nrf2+/+ TBI+atorvastatin, Nrf2-/- TBI, and Nrf2-/- TBI+atorvastatin groups...
January 22, 2023: Neurological Research
Gonulden Aktoz, Cavit Boz, Serap Zengin, Aleyna Caglar Okumus, Hilal Horozoglu, Fatma Kara, Ebru Oral, Mehmet Ozmenoglu
OBJECTIVES: To analyze the prognosis and outcomes of COVID-19 in patients with MG and to determine factors associated with COVID-19 severity in patients with MG. METHODS: Information concerning COVID-19 occurrence in patients with MG was collected in this single-center observational study. Univariate and multivariate analyses were used to identify factors associated with severe Covid-19. RESULTS: Two hundred seventy-five of the 386 records of MG were included in this study...
January 22, 2023: Neurological Research
Chen Lin, Andrea Arevalo, Hely D Nanavati
INTRODUCTION: Patients with ischemic strokes that have undergone mechanical thrombectomy (MT) can still have poor functional outcomes. Limited research exists on factors that impact functional outcomes in these patients who are discharged to inpatient rehabilitation. We examined patient characteristics correlated with 90-day outcomes in ischemic stroke patients having undergone MT and undergo acute rehabilitation. METHODS: This is a retrospective study of patients (≥18 years) who were consecutively admitted to inpatient rehabilitation after undergoing MT following an ischemic stroke event from 2015 through 2018...
January 16, 2023: Neurological Research
Linyun Chen, Feng Liu, Xuan Tian, Tian Zhang, Jian Zhang, Fang Ran
BACKGROUND: Cerebral microbleeds (CMBs) are subclinical lesions of the brain parenchyma and an important marker for the clinical diagnosis of central nervous system vascular disease. However, the relationship between CMBs and cerebral infarction, cerebral hemorrhage, and cognitive impairment remains unclear. METHODS: In order to explore the cognitive function and risk factors of patients with acute cerebral infarction (ACI) complicated with cerebral microbleeds, 190 patients with ACI were collected...
January 9, 2023: Neurological Research
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