journal
https://read.qxmd.com/read/37733422/a-new-instrument-to-assess-physical-function-in-stroke-patients-the-dubousset-function-test-and-its-validity-reliability-responsiveness
#1
JOURNAL ARTICLE
Yusuf Emre Bozkurt, Ayşe Abit Kocaman, Merve Kaşıkcı Çavdar, E Dilek Keskin
AIM: The Dubousset Functional Test (DFT) ia a practical four-component assessment test to assess the physical function and balance capacities. The study aimed to examine the reliability, validity, responsiveness of the DFT in stroke survivors. METHODS: This study included a total of 57 post-stroke patients (age 60.16 ± 15.08 years). The participants were divided into two groups according to the duration of stroke (6-12 months, 12 months and more)...
September 21, 2023: Neurological Research
https://read.qxmd.com/read/37733038/5-alpha-dihydroxyprogesterone-may-contribute-to-perceptual-processing-and-attention-of-the-cases-with-relapsing-remitting-multiple-sclerosis
#2
JOURNAL ARTICLE
Emin Ozcan, Rana Cagla Akduman, Sevim Eyupoglu, Ayhan Bingol, Ozlem Balci Ekmekci, Esra Hatipoglu
Neurosteroids (NSs) are endogenous steroid hormones, which are synthesised and metabolised within the central nervous system (CNS). NSs aid myelination and glial differentiation and modulate cognitive functions. Herein, we aim to investigate the relationship between NS levels, 5-alpha-dihydroxyprogesterone (5-α-DHP) and allopregnanolone (ALPG), and their relationship with cognitive changes in relapsing remitting MS patients.A total of 43 cases with well controlled, relapsing remitting MS composed the study group...
September 21, 2023: Neurological Research
https://read.qxmd.com/read/37733020/cholinergic-deficit-induced-memory-retrieval-impairment-and-hippocampal-camkii-alpha-deregulation-is-counteracted-by-sub-chronic-agmatine-treatment-in-mice
#3
JOURNAL ARTICLE
Vahid Reza Ostovan, Nahid Baberi, Majid Reza Farokhi, Leila Moezi, Fatema Pirsalami, Roksana Soukhaklari, Maryam Moosavi
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disease characterized by brain cholinergic dysfunction. Evidence suggests the impairment of memory retrieval phase in AD. It has been shown that CaMKII-α expressing neurons are selectively reduced in the hippocampus in AD brains. The present study aimed to investigate the effect of scopolamine on the memory retrieval phase and the hippocampal CaMKII-α signaling. In addition, the effect of sub-chronic administration of agmatine against scopolamine induced memory and possible hippocampal CaMKII-α deregulation was investigated in mice...
September 21, 2023: Neurological Research
https://read.qxmd.com/read/37732768/peripheral-electrical-stimulation-on-neuroplasticity-and-motor-function-in-stroke-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Aline Cristina Beijora, Ana Paula Back, Andersom Ricardo Fréz, Márcia Rosângela Buzanello Azevedo, Gladson Ricardo Flor Bertolini
INTRODUCTION: The use of electrotherapy has been presented as a great resource for the professional physiotherapist in the most diverse pathologies. Stroke is a neurological condition responsible for sequelae such as hemiplegia that directly impair the quality of life of patients. OBJECTIVE: This study aimed to review the literature on the effects of electrotherapeutic resources on motor function and neuroplasticity in individuals with post-stroke sequelae. MATERIALS AND METHODS: 2427 articles were found in databases according to search criteria for each base according to the included descriptors (EndNote Web)...
September 21, 2023: Neurological Research
https://read.qxmd.com/read/37729085/retrograde-peripheral-nerve-regeneration-from-sensory-to-motor-pathways-in-rats-a-new-experimental-concept-in-nerve-repair
#5
JOURNAL ARTICLE
Jayme A Bertelli, Isadora Carvalho Nunes Rosa, Marcos F Ghizoni
BACKGROUND: The polarity of nerve grafts does not interfere with axon growth. Our goal was to investigate whether axons can regenerate in a retrograde fashion within sensory pathways and then extend into motor pathways, leading to muscle reinnervation. METHODS: Fifty-four rats were randomized into four groups. In Group 1, the ulnar nerve was connected end-to-end to the superficial radial nerve after neurectomy of the radial nerve in the axilla. In Group 2, the ulnar nerve was connected end-to-end to the radial nerve distal to the humerus; the radial nerve then was divided in the axilla...
September 20, 2023: Neurological Research
https://read.qxmd.com/read/37729011/increased-prevalence-of-mild-myopathic-changes-in-the-post-covid-19-duration
#6
JOURNAL ARTICLE
Ayşegül Gündüz, Merve Hazal Ser, Fatma Zehra Çalıkuşu, Uygur Tanrıverdi, Hikmet Abbaszade, Sena Hakyemez, I Lker İnanç Balkan, Rıdvan Karaali, Fatih Kantarcı, Nurten Uzun Adatepe
OBJECTIVE: There are reports of peripheral nerve and muscle involvement during or after coronavirus disease 2019 (COVID-19), even following a mild infection. Here, we aimed to analyze the objective findings regarding peripheral nerve, neuromuscular junction, and muscle function using electrophysiology in patients with a previous COVID-19 infection. METHODS: All consecutive patients with a history of COVID-19 were questioned for post-COVID-19 duration-related neurological complaints via Composite Autonomic Symptom Score-31 (COMPASS-31), modified Toronto Neuropathy score (mTORONTO), and Fatigue Severity Scale (FSS)...
September 20, 2023: Neurological Research
https://read.qxmd.com/read/37724803/intracranial-arterial-stenosis-and-recurrence-in-stroke-patients-with-different-risk-stratifications-by-essen-stroke-risk-score
#7
JOURNAL ARTICLE
Yue Suo, Jing Jing, Xia Meng, Zixiao Li, Yuesong Pan, Hongyi Yan, Yong Jiang, Liping Liu, Xingquan Zhao, Yilong Wang, Hao Li, Yongjun Wang
OBJECTIVES: We sought to investigate whether the prognostic value of intracranial arterial stenosis (ICAS) is consistent across different risk stratifications using the Essen Stroke Risk score (ESRS). METHODS: We derived data from the Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events trial. Patients without complete baseline brain imaging data were excluded. Participants were categorized into different risk groups based on ESRS (low risk, 0-2, and high risk ≥ 3)...
September 19, 2023: Neurological Research
https://read.qxmd.com/read/37724548/the-acute-effect-of-cervical-mobilization-on-balance-in-patients-with-multiple-sclerosis-a-single-blind-randomized-controlled-trial
#8
JOURNAL ARTICLE
Ecem Karanfil, Yeliz Salci, Ayla Fil Balkan, Aslı Tuncer, Rana Karabudak
UNLABELLED: The cervical region plays an important role in providing proprioceptive and vestibular input to the postural control system. OBJECTIVE: To investigate the effect of cervical mobilization on balance in multiple sclerosis (MS) patients. METHODS: The study was undertaken at the neurological rehabilitation unit with 36 MS participants who were assigned randomly to the study (n = 18) and control group (n = 18). While the study group received a single session of 15 minutes of cervical and soft tissue mobilization, no intervention was applied to the control group to investigate the learning effect of the assessment...
September 19, 2023: Neurological Research
https://read.qxmd.com/read/37722694/clinical-and-surgical-outcome-of-endoscopic-third-ventriculostomy-etv-and-ventriculoperitoneal-shunt-vps-in-patients-with-long-standing-overt-ventriculomegaly-in-adults-lova-a-systematic-review
#9
REVIEW
Nicola Montemurro
OBJECTIVES: The optimal surgical procedure for long-standing overt ventriculomegaly in adults (LOVA) remains controversial. METHODS: A systematic search of three databases was performed for studies published between January 1999 and March 2022. This systematic review included 12 studies with a total of 318 patients with LOVA surgically treated. PRISMA guidelines were followed. RESULTS: Gait disturbance (74.8%) and headache (59.7%) were the most common clinical presentation...
September 18, 2023: Neurological Research
https://read.qxmd.com/read/37712608/balance-and-gait-in-individuals-with-diabetic-peripheral-neuropathy
#10
JOURNAL ARTICLE
Süleyman Korkusuz, Büşra Seçkinoğulları, Zeliha Özlem Yürük, Naime Uluğ, Sibel Kibar
BACKGROUND: Diabetic Peripheral Neuropathy (DPN) causes various physical problems such as the increased risk of falling, loss of balance and coordination while standing or walking, susceptibility to injuries due to sensory loss. AIMS: The aim of the study was to evaluate and compare the effects of neuropathic pain (NP) in individuals with DPN on balance and gait. METHODS: This prospective controlled study was conducted on 42 adults aged between 40-65 years...
September 15, 2023: Neurological Research
https://read.qxmd.com/read/37706249/pharmacogenetic-study-of-phosphatase-and-tensin-homolog-polymorphism-rs701848-in-childhood-epilepsy-relation-to-circulating-wnt-signaling
#11
JOURNAL ARTICLE
Mohammed H Hassan, Ahmed Y Nassar, Abdel-Raheim M A Meki, Shimaa A Nasser, Ali Helmi Bakri, Eman Radwan
OBJECTIVE: The present study aimed at evaluating the potential contribution of Phosphatase and Tensin Homolog (PTEN) and its gene polymorphism (PTEN rs701848 T/C) in relation to Wingless/integrase-1 (Wnt) signaling in childhood epilepsy and the impact of antiepileptic medications on their serum levels. METHODS: This study included 100 children with epilepsy (50 pharmacoresistant and 50 pharmacoresponsive) and 50 matched controls. All subjects had their genotypes for the PTEN rs701848T/C polymorphism assessed using TaqManTM assays and real-time PCR...
September 14, 2023: Neurological Research
https://read.qxmd.com/read/37706246/evaluation-of-the-relationship-between-serum-bdnf-concentration-and-indicators-of-oxidative-stress-and-inflammation-in-covid-19-patients-with-neurological-disorders-a-pilot-study
#12
JOURNAL ARTICLE
Kowsar Bavarsad, Davood Shalil Ahmadi, Mohammad Momeni, Mohammad Jafar Yadyad, Roya Salehi Kahyesh, Hamid Moradzadegan, Samireh Ghafouri
INTRODUCTION: The aim of this study was to determine the effect of serum level of brain-derived neurotrophic factor (BDNF) on the development of neurological disorders in COVID-19 patients and the probable role of oxidative stress and inflammation in this phenomenon. METHODS: The present case-control study included 42 COVID-19 patients referring to Golestan and Sina hospitals of Ahvaz, Iran, for treatment. Patients with ( n  = 18) and without ( n  = 24) neurological disorders were allocated into test and control groups, respectively...
September 14, 2023: Neurological Research
https://read.qxmd.com/read/37703903/autocrine-motility-factor-receptor-promotes-the-malignancy-of-glioblastoma-by-regulating-cell-migration-and-invasion
#13
JOURNAL ARTICLE
Yao Zhang, Xiuping Wang, Guanghui Chen, Yajing Lu, Qiang Chen
OBJECTIVE: One of the important causes of death in cancer patients is malignant metastasis, invasion, and metastasis of tumor cells. Metastasis is also the most basic physiological characteristics and pathogenesis of various tumors. Previously published studies have suggested that autocrine motor factor receptor (AMFR) is the key regulator of tumor cell migration and invasion. Meanwhile, AMFR is highly expressed in esophageal tumors, gastrointestinal tumors, and bladder cancer, and it is also involved in its pathogenesis...
September 13, 2023: Neurological Research
https://read.qxmd.com/read/37702221/mir-148b-3p-suppresses-the-proliferation-and-migration-of-schwann-cells-by-targeting-usp6-following-sciatic-nerve-injury
#14
JOURNAL ARTICLE
Qin Zhang, Chengkun Guo, Lijuan Liu, Yang Li
BACKGROUND: Peripheral nerve injury is a common disorder associated with damaged axons and distal myelin sheath degeneration, and Schwann cells play a paramount role in peripheral nerve regeneration. This study aims to explore the role of microRNA miR-148b-3p on Schwann cells after peripheral nerve injury. METHODS: Sciatic nerve transection was conducted in rat as the model of peripheral nerve injury. The expression level of miR-148b-3p and Ubiquitin Specific Peptidase 6 (USP6) was detected by qRT-PCR and Western blot at diverse time points after nerve transection...
September 13, 2023: Neurological Research
https://read.qxmd.com/read/37700395/high-prognostic-nutritional-index-could-be-associated-with-improved-survival-in-patients-with-brain-metastases-a-retrospective-observational-study
#15
JOURNAL ARTICLE
Ehsan Alimohammadi, Michael T Lawton, Seyed Reza Bagheri, Elham Siahkamari, Hajir Mehrbani, Amirhossein Tondro, Akram Amiri, Parivash Kakavand
BACKGROUND: Prognostic nutritional index (PNI) is an indicator of immunonutritional status. The present study aimed to evaluate the association between PNI and overall survival in patients with brain metastases. METHODS: A total of 257 patients with histologically confirmed brain metastasis who underwent surgery at our center between April 2011 and April 2021 were investigated retrospectively.Demographic, clinical, and radiologic data of all cases were extracted...
September 12, 2023: Neurological Research
https://read.qxmd.com/read/37700391/the-influence-of-symptom-severity-and-fatigue-on-sleep-quality-in-patients-with-myasthenia-gravis
#16
JOURNAL ARTICLE
Pınar Yeşil Demirci, Zehra Eskimez, Saliha Bozdoğan Yeşilot
INTRODUCTION: Myasthenia gravis is a rare and chronic autoimmune disease. The study aimed to evaluate the influence of symptom severity and fatigue on sleep quality in patients with myasthenia gravis. METHODS: This was a cross-sectional study, and the population consisted of patients with MG throughout Turkey. The study was completed with 163 patients on 1 April and 31 July 2022. RESULTS:  It was found that the mean Myasthenia Gravis-Activities of Daily Living Scale score was 6...
September 12, 2023: Neurological Research
https://read.qxmd.com/read/37699515/the-incidence-of-deep-venous-thrombosis-in-parkinson-s-disease
#17
JOURNAL ARTICLE
Emine Afsin, Zeliha Coşgun, Ramazan Kurul, Şule Aydın Türkoğlu
INTRODUCTION: Venous thromboembolism is one of the causes of sudden death in Parkinson's Disease (PD). Few studies have investigated the correlation between PD and deep venous thrombosis (DVT). This study aimed to investigate the frequency of DVT in PD patients prospectively. MATERIAL AND METHOD: Demographic characteristics of 37 PD patients without known risk factors for DVT, disease duration, Hoehn-Yahr (H - Y) stage, oxygen saturation (SpO2) and heart rate values with pulse oximetry, use of assistive devices, waist and knee circumference measurements, and modified Medical Research Council (mMRC) dyspnea score was recorded...
September 12, 2023: Neurological Research
https://read.qxmd.com/read/37699078/effects-of-fluoride-on-oxidative-dna-damage-nitric-oxide-level-lipid-peroxidation-and-cholinesterase-enzyme-activity-in-a-rotenone-induced-experimental-parkinson-s-model
#18
JOURNAL ARTICLE
Yilmaz Kocak, Gokhan Oto, Zubeyir Huyut, Hamit Hakan Alp, Fikret Turkan, Ezgi Onay
OBJECTIVE: Environmental toxins are known to be one of the important factors in the development of Parkinson's disease (PD). This study was designed to investigate the possible contribution of fluoride (F) exposure to oxidative stress and neurodegeneration in rats with PD induced by rotenone (ROT). MATERIALS AND METHODS: A total of 72 Wistar albino male rats were used in the experiment and 9 groups were formed with 8 animals in each group. ROT (2 mg/kg) was administered subcutaneously (sc) for 28 days...
September 12, 2023: Neurological Research
https://read.qxmd.com/read/37698124/consequences-of-adolescent-social-isolation-on-behavior-and-synaptic-plasticity-in-the-dorsal-and-ventral-hippocampus-in-male-wistar-rats
#19
JOURNAL ARTICLE
Oksana Nikolaienko, Mariia Klymenko, Elena Isaeva
OBJECTIVE: Social interaction at a young age plays a critical role in the normal maturation of the brain and neuroendocrine system. Deprivation of social contacts has been associated with numerous cognitive and emotional abnormalities. However, neurobiological mechanisms that may underlie these effects remain poorly understood. In the present study, we examined the effect of 4-6-week social isolation during the adolescent period on rat spatial memory and emotional responses and investigated synaptic plasticity in the dorsal (DH) and ventral hippocampus (VH), which are known to be differently involved in these behaviors...
September 12, 2023: Neurological Research
https://read.qxmd.com/read/37695813/the-efficacy-of-buprenorphine-on-moderate-traumatic-brain-injury-in-the-rat-model
#20
JOURNAL ARTICLE
Hamid Reza Rasouli, Mehdi Mohammadian Salim, Samira Talebi, Mohammad Eslamian, Fathollah Ahmadpour
INTRODUCTION: Traumatic brain injury (TBI) is the leading cause of death, disability, and mental health disorders. A wide range of bioactive lipids, cytokines, and chemokines drives the inflammatory response. This study aimed to assess the efficacy of buprenorphine on moderate Trauma Brain Injury (mTBI) in rats. METHODS: In this study, 21 Wistar male rats weighing 230 ± 10 g were included. We trained cases by Morris water navigation task and mTBI induced by the pendulum...
September 11, 2023: Neurological Research
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