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Neurological Research

Christopher R Stone, Xiaokun Geng, Yuchuan Ding
No abstract text is available yet for this article.
April 14, 2019: Neurological Research
Dalia G Mostafa, Eman F Khaleel, Rehab M Badi, Ghada A Abdel-Aleem, Hanaa M Abdeen
Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective and an antioxidant flavonoid, can ameliorate cadmium chloride (CdCl2)-induced neurotoxicity by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl2 (5 mg/kg), and CdCl2 + RH...
April 11, 2019: Neurological Research
Azam Alinaghipour, Tahereh Mazoochi, Abolfazl Ardjmand
OBJECTIVE: The present study aimed to evaluate the ameliorative effect of low-dose ethanol (Eth) on amnesia induced by a brief seizure model and the role of N-methyl D-aspartate (NMDA) signaling in this event. MATERIALS AND METHODS: Four groups of rats (total number = 36; n = 9, each group) were used: control, Eth (0.5 g/kg/i.p.), pentylenetetrazole (PTZ) (60 mg/kg/i.p.), and Eth+PTZ. Eth was administered for 6 days before the single injection of PTZ, at minute dose that cannot induce memory impairment...
April 9, 2019: Neurological Research
Fei Li, Qian-Xue Chen, Bo Peng, Yan Chen, Tao Yao, Guan Wang
OBJECTIVE: Microalbuminuria could be detected in patients with acute stroke. However, the association between microalbuminuria and the severity of ischemic stroke has not been systematically investigated. This study aimed to systematically explore the prevalence of microalbuminuria in ischemic stroke patients, and the association of microalbuminuria with the severity of ischemic stroke, as well as the prognostic value of microalbuminuria in cerebral infarction patients. METHODS: 160 ischemic stroke patients and 54 controls were enrolled and clinical characteristics were recorded...
April 1, 2019: Neurological Research
Yuan Guo, Li Zhang, Jin Zhang, Cheng-Xue Du, Shu-Xuan Lv, Tao Wang, Hui-Sheng Wang, Wen Xie, Jian Liu
OBJECTIVE: The aim of the present study was to investigate the effects and mechanism of 6-hydroxydopamine (6-OHDA) lesions and serotonin 4  (5-HT4 ) receptors in the lateral habenula (LHb) on Parkinson's disease (PD) related working memory. METHODS: The working memory was measured by the T-maze rewarded alternation test in sham rats and rats with unilateral 6-OHDA lesions of substantia nigra pars compacta (SNc). The concentrations of dopamine (DA), noradrenaline (NA) and 5-HT in the related brain regions were measured by neurochemistry...
March 30, 2019: Neurological Research
Azam Alenajaf, Ehsan Mohebi, Ali Moghimi, Masoud Fereidooni, Mohammad Mohammad-Zadeh
OBJECTIVE: Harmaline and other beta-carbolines act as an inverse agonist for GABA-A receptors and cause central nervous system stimulation and anxiety; thus, it may act hypothetically as a potential seizure augmenter. To examine the hypothesis, the effect of harmaline during the seizures induced by amygdala kindling is investigated here. METHODS: Seven groups of male rats were kindled by daily electrical stimulation of the amygdala. After being kindled, Groups I-III, respectively, received 5, 15 and 50 mg/kg harmaline through intraperitoneal injection...
March 19, 2019: Neurological Research
Jérôme Franques, Laurent Chiche, André Maues De Paula, Aude Marie Grapperon, Shahram Attarian, Jean Pouget, Stephane Mathis
BACKGROUND: Vitamin B12 (B12) has a fundamental role in both central and peripheral nervous system function at all ages. Neurologic manifestations may be the earliest and often the only manifestation of B12 deficiency. Mostly because of the poor sensitivity of methods of determination for B12 levels, peripheral neuropathy remains a classical but underdiagnosed complication of B12 deficiency. So the clinical and electrophysiological characteristics of B12-responsive neuropathy are not well known...
March 19, 2019: Neurological Research
Alireza Abdanipour, Fatemeh Moradi, Farzaneh Fakheri, Mehrdad Ghorbanlou, Reza Nejatbakhsh
OBJECTIVE: Nowadays, there seems to be no decisive way for treatment of spinal cord injury (SCI).Extensive cell death (apoptosis and necrosis) occurring in SCI can cause considerable progressive sensorimotor disabilities. Preventing cell death by improving endogenous regenerative capability could an effective strategy for the treatment of SCI. This study was designed to evaluate the effects of lithium chloride (LiCl) on the cell survival through overexpression of BDNF and NT3 mRNA level and their receptors in the contusion rat models...
March 17, 2019: Neurological Research
Xiaowei Zheng, Nimei Zeng, Aili Wang, Zhengbao Zhu, Hao Peng, Chongke Zhong, Tan Xu, Tian Xu, Yanbo Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
BACKGROUND AND AIMS: The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear. METHODS: A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. The primary outcome was a composite outcome of death and vascular events within 1 year after stroke. Multivariable Cox proportional hazard models were used to analyze the association between family history of stroke and other variables and clinical outcomes...
March 4, 2019: Neurological Research
Mingyong Liu, Yuesong Pan, Lichun Zhou, Yongjun Wang
BACKGROUND: Recombinant tissue plasminogen activator (rt-PA) has been used as the standard treatment for acute ischemic stroke (AIS). The following study investigates whether low-dose rt-PA can decrease the incidence of symptomatic intracranial haemorrhage (sICH) in AIS patients with high-risk sICH compared to standard-dose rt-PA. MATERIALS AND METHODS: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) studies were assessed to explore risk factors for sICH after intravenous thrombolysis...
March 1, 2019: Neurological Research
Ezgi Bektur, Erhan Şahin, Emre Ceyhan, Dilek Burukoglu Donmez, Mediha Canbek, Cengiz Baycu, Ozgur Devrim Can
OBJECTIVES: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids as well as capsaicin cream or lidocaine patches. However, since the majority of patients do not or partially respond to current treatments, there is a growing necessity for new drugs increasing the pain relief in patients with diabetes. Therefore, based on the therapeutic potential of antidepressants on neuropathic pain, we investigated the promising antihyperalgesic effect of mirtazapine (MRT) in painful diabetic neuropathy...
March 1, 2019: Neurological Research
Takuto Terashi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Koki Ueda, Megumi Sumizono, Kiyoshi Kikuchi, Harutoshi Sakakima
OBJECTIVE: Preconditioning exercise can exert neuroprotective effects after stroke; however, the effects of exercise intensity, frequency, duration are unknown. We investigated the neuroprotective effect of different frequency preconditioning exercise on neuronal apoptosis after cerebral ischemia in rats. METHODS: Rats were divided into the following five groups: 5 times a week of exercise (5/w-Ex) group, 3 times a week of exercise (3/w-Ex) group, once a week of exercise (1/w-Ex) group, no exercise (No-Ex) group, and intact control (control) group...
March 1, 2019: Neurological Research
Maylin Wong-Guerra, Javier Jiménez-Martin, Luis Arturo Fonseca-Fonseca, Jeney Ramírez-Sánchez, Yanay Montano-Peguero, Joao Batista Rocha, Fernanda D Avila, Adriano M de Assis, Diogo Onofre Souza, Gilberto L Pardo-Andreu, Roberto Menéndez-Soto Del Valle, Guillermo Aparicio Lopez, Odalys Valdés Martínez, Nelson Merino García, Abel Mondelo-Rodríguez, Alejandro Saúl Padrón-Yaquis, Yanier Nuñez-Figueredo
OBJECTIVE: JM-20, a novel hybrid synthetic molecule, has been reported to have antioxidant, mitoprotective, anti-excitotoxic, anti-apoptotic and anti-inflammatory properties. However, the neuroprotective effect of JM-20 against memory impairment in preclinical AD-like models has not been analyzed. The aim of this study was to evaluate the potential neuroprotection of JM-20 that preserves essential memory process from cholinergic dysfunction and other molecular damages. METHODS: The effects of JM-20 on scopolamine (1 mg/kg)-induced cognitive disorders were studied...
March 1, 2019: Neurological Research
Myeong Jin Kim, Joonho Chung, Yong Sam Shin, Yong Cheol Lim
BACKGROUND: Coil embolization with multiple overlapping stents was performed as an alternative treatment option for blood blister-like aneurysms (BBAs). However, coil placement into the BBAs has the inherent risks of rupture and regrowth. We describe a safe dense coil packing technique into and just proximal of BBAs using a semi-jailing technique for the treatment of BBAs of the internal carotid artery (ICA) and report the long-term clinical outcomes. METHODS: The technique involves the partial deployment of a self-expanding and retrievable stent from the ICA bifurcation to the mid-portion of a BBA followed by coil embolization with gradual unsheathing of the stent from the BBA to its just proximal portion...
March 1, 2019: Neurological Research
Gaowei Li, Linjun Cai, Liangxue Zhou
OBJECTIVE: Chordoma is a rare tumor with a certain rate of distant metastasis. Skull base and sacrum are the two most common origin sites. This study tends to identify key differentially expressed genes (DEGs) between classical clival and sacral chordomas, provide new targets for future treatment options of chordomas. METHODS: The gene expression profiles of GSE95084 and GSE68497 were downloaded from Gene Expression Omnibus database and were analyzed using the limma R package...
March 1, 2019: Neurological Research
Yuan Qiao, Qing Ma, Haifeng Zhai, Ya Li, Minke Tang
OBJECTIVE: Exposure to female estrous, a natural rewarding experience, alleviates anxiety and depression, and the contribution of this behavior to stroke outcome is unknown. The aim of this study was to evaluate whether exposure to female estrous is beneficial to recovery following transient ischemic stroke in male mice. METHODS: Cerebral ischemia was induced in male ICR mice with thread occlusion of the middle cerebral artery (MCAO) for 30 min followed by reperfusion...
February 27, 2019: Neurological Research
Satoshi Ando, Shouta Tsutsui, Kenya Miyoshi, Shinpei Sato, Wataru Yanagihara, Kengo Setta, Takayuki Chiba, Shunrou Fujiwara, Masakazu Kobayashi, Kenji Yoshida, Yoshitaka Kubo, Kuniaki Ogasawara
OBJECTIVE: Adult patients with ischemic moyamoya disease (MMD) who receive treatment with antiplatelet drugs reportedly show improvements in neuropsychological test scores after around 2 years. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, results in better improvement of cognitive function among non-surgical adult patients showing ischemic MMD without severe hemodynamic compromise...
February 18, 2019: Neurological Research
Pedro Montes, Rosa María Vigueras-Villaseñor, Julio César Rojas-Castañeda, Tomas Monfil, Miguel Cervantes, Gabriela Moralí
OBJECTIVE: Rats treated with progesterone (P4) after ischemia show an adequate functional performance despite a significant loss of hippocampal pyramidal neurons, suggesting that P4 could favour a permissive microenvironment for cerebral plasticity mechanisms. The possibility of P4 treatment promoting the survival of newly generated hippocampal neurons, in relation to the performance of ischemic rats in a spatial learning task, was assessed in this study. METHODS: Adult male rats were subjected to a severe global cerebral ischemia episode (30 min) and treated with P4 or its vehicle at 15 min, 2, 6, 24, 48 and 72 h of reperfusion...
February 14, 2019: Neurological Research
Qi Wu, Dongyang Han, Jiangkuan Zhang, Xin Li
OBJECTIVE: The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features. METHODS: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Correlation analysis was used to evaluate the correlation between the protein expression and AD clinical parameters...
February 14, 2019: Neurological Research
Ruijun Ji, Kai Yu, Guoyang Li, Xinyu Liu, Yinglin Yan, Suying Gao, Hongna Yang, Shangmin Qin, Fang Li, Guangbo Zhang, Bo Yang, Yan He, Yongna Zhao, Enjing Li, Lihua Xu, Na Zhang, Dongna Fan, Dongliang Liu
BACKGROUND AND PURPOSE: To develop and validate a risk model (Extracranial Carotid Artery Stenosis progression score, ECAS-PS) and to predict risk of ECAS progression. METHODS: The ECAS-PS was developed based on the Renqiu Stroke Screening Study (RSSS), in which eligible participants were randomly divided into derivation (60%) and validation (40%) cohorts. ECAS at baseline and follow-up was diagosed by carotid duplex ultrasound according to the published criteria...
February 13, 2019: Neurological Research
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