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Neurological Research | Page 2

John K Yue, Harvey S Levin, Catherine G Suen, Molly Rose Morrissey, Sarah J Runyon, Ethan A Winkler, Ross C Puffer, Hansen Deng, Caitlin K Robinson, Jonathan W Rick, Ryan R L Phelps, Sourabh Sharma, Sabrina R Taylor, Mary J Vassar, Maryse C Cnossen, Hester F Lingsma, Raquel C Gardner, Nancy R Temkin, Jason Barber, Sureyya S Dikmen, Esther L Yuh, Pratik Mukherjee, Murray B Stein, Tene A Cage, Alex B Valadka, David O Okonkwo, Geoffrey T Manley
INTRODUCTION: Risk factors for young adults with mTBI are not well understood. Improved understanding of age and sex as risk factors for impaired six-month outcomes in young adults is needed. METHODS: Young adult mTBI subjects aged 18-39 years (18-29y; 30-39y) with six-month outcomes were extracted from the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study. Multivariable regressions were performed for outcomes with age, sex, and the interaction factor age-group*sex as variables of interest, controlling for demographic and injury variables...
April 21, 2019: Neurological Research
Flavia Turcato, Cayo Almeida, Clarissa Mota, Ricardo Kusuda, Andrea Carvalho, Glauce C Nascimento, Sonia Zanon, Christie R Leite-Panissi, Guilherme Lucas
OBJECTIVE: Animal models of chronic pain have demonstrated that glial cells are promising target for development of analgesic drugs. However, preclinical studies on glial response under chronic pain conditions vary depending on the cellular markers, the species used, the experimental design and model. Therefore, we investigate the expression profile of GFAP and Iba-1 during the behavioral manifestation of sensory disorder in inflammatory and neuropathic pain models. METHODS: the expression profile of fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule-1 (Iba-1) were quantitated in the spinal dorsal horn of Balb/C mice submitted to six models of chronic pain...
April 19, 2019: Neurological Research
Christopher R Stone, Xiaokun Geng, Yuchuan Ding
No abstract text is available yet for this article.
April 14, 2019: Neurological Research
Dalia G Mostafa, Eman F Khaleel, Rehab M Badi, Ghada A Abdel-Aleem, Hanaa M Abdeen
Recent evidence has suggested that cadmium (Cd) ions-induced neurotoxicity is associated with increased oxidative stress and mitochondrial-dependent and endoplasmic reticulum (ER) stress-induced apoptosis. This study aimed to investigate if rutin hydrate (RH), a well-reported neuroprotective and an antioxidant flavonoid, can ameliorate cadmium chloride (CdCl2)-induced neurotoxicity by inhibiting the resultant ER stress. Rats were divided into 4 groups (n = 16/group) of control, control + RH (100 mg/kg), CdCl2 (5 mg/kg), and CdCl2 + RH...
April 11, 2019: Neurological Research
Azam Alinaghipour, Tahereh Mazoochi, Abolfazl Ardjmand
OBJECTIVE: The present study aimed to evaluate the ameliorative effect of low-dose ethanol (Eth) on amnesia induced by a brief seizure model and the role of N-methyl D-aspartate (NMDA) signaling in this event. MATERIALS AND METHODS: Four groups of rats (total number = 36; n = 9, each group) were used: control, Eth (0.5 g/kg/i.p.), pentylenetetrazole (PTZ) (60 mg/kg/i.p.), and Eth+PTZ. Eth was administered for 6 days before the single injection of PTZ, at minute dose that cannot induce memory impairment...
April 9, 2019: Neurological Research
Yuan Guo, Li Zhang, Jin Zhang, Cheng-Xue Du, Shu-Xuan Lv, Tao Wang, Hui-Sheng Wang, Wen Xie, Jian Liu
OBJECTIVE: The aim of the present study was to investigate the effects and mechanism of 6-hydroxydopamine (6-OHDA) lesions and serotonin 4  (5-HT4 ) receptors in the lateral habenula (LHb) on Parkinson's disease (PD) related working memory. METHODS: The working memory was measured by the T-maze rewarded alternation test in sham rats and rats with unilateral 6-OHDA lesions of substantia nigra pars compacta (SNc). The concentrations of dopamine (DA), noradrenaline (NA) and 5-HT in the related brain regions were measured by neurochemistry...
March 30, 2019: Neurological Research
Azam Alenajaf, Ehsan Mohebi, Ali Moghimi, Masoud Fereidooni, Mohammad Mohammad-Zadeh
OBJECTIVE: Harmaline and other beta-carbolines act as an inverse agonist for GABA-A receptors and cause central nervous system stimulation and anxiety; thus, it may act hypothetically as a potential seizure augmenter. To examine the hypothesis, the effect of harmaline during the seizures induced by amygdala kindling is investigated here. METHODS: Seven groups of male rats were kindled by daily electrical stimulation of the amygdala. After being kindled, Groups I-III, respectively, received 5, 15 and 50 mg/kg harmaline through intraperitoneal injection...
March 19, 2019: Neurological Research
Jérôme Franques, Laurent Chiche, André Maues De Paula, Aude Marie Grapperon, Shahram Attarian, Jean Pouget, Stephane Mathis
BACKGROUND: Vitamin B12 (B12) has a fundamental role in both central and peripheral nervous system function at all ages. Neurologic manifestations may be the earliest and often the only manifestation of B12 deficiency. Mostly because of the poor sensitivity of methods of determination for B12 levels, peripheral neuropathy remains a classical but underdiagnosed complication of B12 deficiency. So the clinical and electrophysiological characteristics of B12-responsive neuropathy are not well known...
March 19, 2019: Neurological Research
Alireza Abdanipour, Fatemeh Moradi, Farzaneh Fakheri, Mehrdad Ghorbanlou, Reza Nejatbakhsh
OBJECTIVE: Nowadays, there seems to be no decisive way for treatment of spinal cord injury (SCI).Extensive cell death (apoptosis and necrosis) occurring in SCI can cause considerable progressive sensorimotor disabilities. Preventing cell death by improving endogenous regenerative capability could an effective strategy for the treatment of SCI. This study was designed to evaluate the effects of lithium chloride (LiCl) on the cell survival through overexpression of BDNF and NT3 mRNA level and their receptors in the contusion rat models...
March 17, 2019: Neurological Research
Xiaowei Zheng, Nimei Zeng, Aili Wang, Zhengbao Zhu, Hao Peng, Chongke Zhong, Tan Xu, Tian Xu, Yanbo Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
BACKGROUND AND AIMS: The association between family history of stroke and clinical outcomes after ischemic stroke remains unclear. METHODS: A total of 3878 acute ischemic stroke patients from CATIS were included. The participants with ischemic stroke were divided into groups according to types of family history of stroke, stroke onset age and stroke subtypes. The primary outcome was a composite outcome of death and vascular events within 1 year after stroke. Multivariable Cox proportional hazard models were used to analyze the association between family history of stroke and other variables and clinical outcomes...
March 4, 2019: Neurological Research
Mingyong Liu, Yuesong Pan, Lichun Zhou, Yongjun Wang
BACKGROUND: Recombinant tissue plasminogen activator (rt-PA) has been used as the standard treatment for acute ischemic stroke (AIS). The following study investigates whether low-dose rt-PA can decrease the incidence of symptomatic intracranial haemorrhage (sICH) in AIS patients with high-risk sICH compared to standard-dose rt-PA. MATERIALS AND METHODS: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) studies were assessed to explore risk factors for sICH after intravenous thrombolysis...
March 1, 2019: Neurological Research
Ezgi Bektur, Erhan Şahin, Emre Ceyhan, Dilek Burukoglu Donmez, Mediha Canbek, Cengiz Baycu, Ozgur Devrim Can
OBJECTIVES: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids as well as capsaicin cream or lidocaine patches. However, since the majority of patients do not or partially respond to current treatments, there is a growing necessity for new drugs increasing the pain relief in patients with diabetes. Therefore, based on the therapeutic potential of antidepressants on neuropathic pain, we investigated the promising antihyperalgesic effect of mirtazapine (MRT) in painful diabetic neuropathy...
March 1, 2019: Neurological Research
Takuto Terashi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Koki Ueda, Megumi Sumizono, Kiyoshi Kikuchi, Harutoshi Sakakima
OBJECTIVE: Preconditioning exercise can exert neuroprotective effects after stroke; however, the effects of exercise intensity, frequency, duration are unknown. We investigated the neuroprotective effect of different frequency preconditioning exercise on neuronal apoptosis after cerebral ischemia in rats. METHODS: Rats were divided into the following five groups: 5 times a week of exercise (5/w-Ex) group, 3 times a week of exercise (3/w-Ex) group, once a week of exercise (1/w-Ex) group, no exercise (No-Ex) group, and intact control (control) group...
March 1, 2019: Neurological Research
Maylin Wong-Guerra, Javier Jiménez-Martin, Luis Arturo Fonseca-Fonseca, Jeney Ramírez-Sánchez, Yanay Montano-Peguero, Joao Batista Rocha, Fernanda D Avila, Adriano M de Assis, Diogo Onofre Souza, Gilberto L Pardo-Andreu, Roberto Menéndez-Soto Del Valle, Guillermo Aparicio Lopez, Odalys Valdés Martínez, Nelson Merino García, Abel Mondelo-Rodríguez, Alejandro Saúl Padrón-Yaquis, Yanier Nuñez-Figueredo
OBJECTIVE: JM-20, a novel hybrid synthetic molecule, has been reported to have antioxidant, mitoprotective, anti-excitotoxic, anti-apoptotic and anti-inflammatory properties. However, the neuroprotective effect of JM-20 against memory impairment in preclinical AD-like models has not been analyzed. The aim of this study was to evaluate the potential neuroprotection of JM-20 that preserves essential memory process from cholinergic dysfunction and other molecular damages. METHODS: The effects of JM-20 on scopolamine (1 mg/kg)-induced cognitive disorders were studied...
March 1, 2019: Neurological Research
Myeong Jin Kim, Joonho Chung, Yong Sam Shin, Yong Cheol Lim
BACKGROUND: Coil embolization with multiple overlapping stents was performed as an alternative treatment option for blood blister-like aneurysms (BBAs). However, coil placement into the BBAs has the inherent risks of rupture and regrowth. We describe a safe dense coil packing technique into and just proximal of BBAs using a semi-jailing technique for the treatment of BBAs of the internal carotid artery (ICA) and report the long-term clinical outcomes. METHODS: The technique involves the partial deployment of a self-expanding and retrievable stent from the ICA bifurcation to the mid-portion of a BBA followed by coil embolization with gradual unsheathing of the stent from the BBA to its just proximal portion...
March 1, 2019: Neurological Research
Gaowei Li, Linjun Cai, Liangxue Zhou
OBJECTIVE: Chordoma is a rare tumor with a certain rate of distant metastasis. Skull base and sacrum are the two most common origin sites. This study tends to identify key differentially expressed genes (DEGs) between classical clival and sacral chordomas, provide new targets for future treatment options of chordomas. METHODS: The gene expression profiles of GSE95084 and GSE68497 were downloaded from Gene Expression Omnibus database and were analyzed using the limma R package...
March 1, 2019: Neurological Research
Yuan Qiao, Qing Ma, Haifeng Zhai, Ya Li, Minke Tang
OBJECTIVE: Exposure to female estrous, a natural rewarding experience, alleviates anxiety and depression, and the contribution of this behavior to stroke outcome is unknown. The aim of this study was to evaluate whether exposure to female estrous is beneficial to recovery following transient ischemic stroke in male mice. METHODS: Cerebral ischemia was induced in male ICR mice with thread occlusion of the middle cerebral artery (MCAO) for 30 min followed by reperfusion...
February 27, 2019: Neurological Research
Fei Li, Qian-Xue Chen, Bo Peng, Yan Chen, Tao Yao, Guan Wang
OBJECTIVE: Microalbuminuria could be detected in patients with acute stroke. However, the association between microalbuminuria and the severity of ischemic stroke has not been systematically investigated. This study aimed to systematically explore the prevalence of microalbuminuria in ischemic stroke patients, and the association of microalbuminuria with the severity of ischemic stroke, as well as the prognostic value of microalbuminuria in cerebral infarction patients. METHODS: 160 ischemic stroke patients and 54 controls were enrolled and clinical characteristics were recorded...
June 2019: Neurological Research
Ming-Zhe Hu, An-Rong Wang, Ze-Yu Zhao, Xiang-Yan Chen, Yan-Bin Li, Bin Liu
BACKGROUND: Post-stroke depression (PSD) is one of the most prevalent emotional disorders after stroke and often results in poor outcomes. However, the underlying physiopathologic mechanism and effective treatment of PSD remain poorly elucidated. OBJECTIVE: To investigate whether paeoniflorin has antidepressant-like activity in a rat model of PSD. METHODS: Rats were randomly divided into four groups: sham-operated control (Sham), PSD, paeoniflorin (with PSD) and fluoxetine group(with PSD)...
May 2019: Neurological Research
Nicole Elisabeth Ørsted Schultz, Henrik Hasseldam, Rune Skovgaard Rasmussen, Nina Vindegaard, Oskar McWilliam, Helle Klingenberg Iversen, Flemming Fryd Johansen
OBJECTIVE: In this clinical case-control study, we investigated statin treatment in stroke patients on a range of inflammatory effectors in peripheral blood. We focus on RhoA GTPase and its downstream effectors as a future inflammatory target in stroke treatment. METHODS: Data from 10 patients already on statins at stroke onset (Pre-S group) was compared with data from both 29 patients starting statin treatment right after stroke onset (Post-S group) and with 8 healthy controls...
April 2019: Neurological Research
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