journal
https://read.qxmd.com/read/37931016/metagenomic-next-generation-sequencing-for-diagnosis-of-infectious-encephalitis-and-meningitis-a-retrospective-study-of-90-patients
#21
JOURNAL ARTICLE
Mengling Zhang, Lanlan Chen, Haina Zhao, Tingting Qiao, Li Jiang, Chenxin Wang, Xingxing Zhong, Xiaobo Li, Yao Xu
BACKGROUND: Infections of the central nervous system (CNS) are potentially life-threatening and can cause serious morbidity. We evaluated the clinical value of metagenomic next-generation sequencing (mNGS) in the diagnosis of infectious encephalitis and meningitis and explored the factors affecting the results of mNGS. METHODS: Patients with suspected cases of encephalitis or meningitis who presented in Northern Jiangsu People's Hospital from 1 March 2018 to 30 September 2022 were collected...
February 2024: Neurological Research
https://read.qxmd.com/read/37899006/central-and-peripheral-mechanism-of-mots-c-attenuates-pain-hypersensitivity-in-a-mice-model-of-inflammatory-pain
#22
JOURNAL ARTICLE
Zhe Wang, Long Yang, Lingfei Xu, Jinglei Liao, Ping Lu, Jinhong Jiang
BACKGROUND: Inflammatory pain is caused by damaged tissue or noxious stimuli, accompanied by the release of inflammatory mediators that often leads to severe hyperalgesia and allodynia with limited therapy options. Recently, a novel mitochondrial-derived peptide (named MOTS-c) was reported to regulate obesity, metabolic homeostasis and inflammatory response. The aim of this study was to investigate the effects of MOTS-c and its related regulatory mechanisms involved in inflammatory pain...
February 2024: Neurological Research
https://read.qxmd.com/read/37853768/association-of-il-6-rs1800795-but-not-tnf-%C3%AE-rs1800629-and-il-1%C3%AE-rs16944-polymorphisms-genotypes-with-recovery-of-ischemic-stroke-patients-following-thrombolysis
#23
JOURNAL ARTICLE
Marija Dusanovic Pjevic, Ljubica Vojvodic, Milka Grk, Jovana Todorovic, Nela Maksimovic, Milica Rasic, Dijana Perovic, Tatjana Damnjanovic, Jelena Trickovic, Katarina Kacar, Biljana Jekic
OBJECTIVES: Inflammatory cytokines like tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 can cause brain injury, slow recovery, and adverse effects (ADEs) in ischemic stroke (IS) patients treated with recombinant tissue plasminogen activator (rtPA). We explored the relationship between selected polymorphisms within TNF-α , IL-1β and IL-6 genes, and post-IS outcome and ADEs in patients treated with rtPA. METHODS: One hundred and sixty-six patients with IS treated with rtPA were included in this study...
February 2024: Neurological Research
https://read.qxmd.com/read/37823378/correlation-between-trunk-function-improvement-and-recovery-of-activities-of-daily-living-after-stroke-in-older-adult-patients
#24
JOURNAL ARTICLE
Keisuke Sato, Takahiro Ogawa
OBJECTIVES: To examine the impact of improved trunk function on activities of daily living in stroke patients using the Functional Independence Measure (FIM). METHODS: This retrospective observational study was conducted on patients aged ≥ 65 years who had cerebral infarction. Patients were divided into a group with improved trunk function and a group without trunk function improvement based on the difference between the calculated Functional Assessment for Control of Trunk (FACT) gain at discharge and admission...
February 2024: Neurological Research
https://read.qxmd.com/read/37757588/overlooked-evidence-for-transmission-deficit-of-pupillary-light-reflex-can-be-secondary-to-trigeminal-nerve-ganglion-degeneration-following-subarachnoid-hemorrhage-preliminary-experimental-study
#25
JOURNAL ARTICLE
Mehmet Hakan Sahin, Ayhan Kanat, Mehmet Kursat Karadag, Mehmet Emin Akyuz, Osman Nuri Keles, Omer Lutfi Gundogdu, Huseyin Findik, Mehmet Dumlu Aydin, Mehmet Selim Gel, Iskender Samet Daltaban
OBJECTIVE: Although the effect of oculomotor and cervical sympathetic networks on pupil diameter is well known; the effect of the trigeminal nerve on pupil diameter has not been investigated yet. This subject was investigated. MATERIALS AND METHODS: Five of 23 rabbits were used as a control group (GI; n  = 5); 0.5 ccs saline solution into cisterna magna injected animals used as SHAM (GII; n  = 5); autologous blood injected to produce SAH used as the study group (GIII; n  = 13) and followed up three weeks...
February 2024: Neurological Research
https://read.qxmd.com/read/37733038/5-alpha-dihydroxyprogesterone-may-contribute-to-perceptual-processing-and-attention-of-the-cases-with-relapsing-remitting-multiple-sclerosis
#26
JOURNAL ARTICLE
Emin Ozcan, Rana Cagla Akduman, Sevim Eyupoglu, Ayhan Bingol, Ozlem Balci Ekmekci, Esra Hatipoglu
Neurosteroids (NSs) are endogenous steroid hormones, which are synthesised and metabolised within the central nervous system (CNS). NSs aid myelination and glial differentiation and modulate cognitive functions. Herein, we aim to investigate the relationship between NS levels, 5-alpha-dihydroxyprogesterone (5-α-DHP) and allopregnanolone (ALPG), and their relationship with cognitive changes in relapsing remitting MS patients.A total of 43 cases with well controlled, relapsing remitting MS composed the study group...
February 2024: Neurological Research
https://read.qxmd.com/read/37935114/development-and-characterisation-of-mgthp-1-a-novel-in-vitro-model-for-neural-macrophages-with-microglial-characteristics
#27
JOURNAL ARTICLE
E Kodosaki, A Daniels-Morgan, N Hassan, R Webb, K Morris, C M Kelly
Neuroinflammation is primarily characterised by activation of the brain's resident macrophages - the microglia. However, other central nervous system (CNS) cells also contribute to this response, including the astrocytes and endothelial cells. In addition, there is infiltration into the CNS of peripherally derived immune cells. Together these cells mediate inflammation by the production of cytokines, chemokines, reactive oxygen species, and secondary messengers, and enacting of the appropriate response to those signals...
January 2024: Neurological Research
https://read.qxmd.com/read/37850443/comparison-of-different-methods-used-in-balance-evaluation-in-children-with-diparetic-cerebral-palsy
#28
JOURNAL ARTICLE
Ayşegül Göktürk Usta, Kadriye Armutlu
PURPOSE: In this study, we aimed to investigate the validity and reliability of Single Leg Stance (SLS), Tandem Stance (TS) and Pediatric Reach Tests (PRT) in children with Cerebral Palsy (CP). METHODS: Fifty-three children (31 boys, 22 girls, age:3-15 years, Gross Motor Function Classification System (GMFCS) Level I- II with diparetic CP were included the study. SLS, TS, PRT test used for balance evaluations. SLS test was made by standing on dominant (D) and non-dominant (ND) extremity both eyes opened (EO) and closed (EC)...
January 2024: Neurological Research
https://read.qxmd.com/read/37842946/the-effects-of-dexmedetomidine-on-trauma-induced-secondary-injury-in-rat-brain
#29
JOURNAL ARTICLE
Ahmet Sen, Basar Erdivanlı, Levent Tümkaya, Hüseyin Avni Uydu, Tolga Mercantepe, Şule Batcik, Abdullah Ozdemir
BACKGROUND: The objective of this study was to investigate the effect of dexmedetomidine (Dex), a sedative drug with little or no depressant effect on respiratory centers, on secondary injury in rat brain tissue by means of the Na+/K+ ATPase enzyme, which maintains the cell membrane ion gradient; malondialdehyde, an indicator of membrane lipid peroxidation; glutathione, an indicator of antioxidant capacity; and histopathological analyses. METHODS: Eighteen rats were randomized into three groups: the trauma group received anesthesia, followed by head trauma with a Mild Traumatic Brain Injury Apparatus; the Trauma+Dex group received an additional treatment of 100 µg/kg intraperitoneal dexmedetomidine daily for three days; the Control group received anesthesia only...
January 2024: Neurological Research
https://read.qxmd.com/read/37842802/mir-184-5p-represses-neuropathic-pain-by-regulating-ccl1-ccr8-signaling-interplay-in-the-spinal-cord-in-diabetic-mice
#30
JOURNAL ARTICLE
Danlei Wu, Shuotao Zhong, Huiying Du, Shuang Han, Xuhong Wei, Qingjuan Gong
BACKGROUND: Diabetic neuropathic pain (DNP) is a serious complication for diabetic patients involving nervous system. MicroRNAs (miRNAs) are small-noncoding RNAs which are dysregulated in neuropathic pain, and might be critical molecules for pain treatment. Our previous study has shown miR-184-5p was significantly downregulated in DNP. Therefore, the mechanism of miR-184-5p in DNP was investigated in this study. METHODS: A DNP model was established through streptozotocin (STZ)...
January 2024: Neurological Research
https://read.qxmd.com/read/37724548/the-acute-effect-of-cervical-mobilization-on-balance-in-patients-with-multiple-sclerosis-a-single-blind-randomized-controlled-trial
#31
RANDOMIZED CONTROLLED TRIAL
Ecem Karanfil, Yeliz Salci, Ayla Fil Balkan, Aslı Tuncer, Rana Karabudak
UNLABELLED: The cervical region plays an important role in providing proprioceptive and vestibular input to the postural control system. OBJECTIVE: To investigate the effect of cervical mobilization on balance in multiple sclerosis (MS) patients. METHODS: The study was undertaken at the neurological rehabilitation unit with 36 MS participants who were assigned randomly to the study (n = 18) and control group (n = 18). While the study group received a single session of 15 minutes of cervical and soft tissue mobilization, no intervention was applied to the control group to investigate the learning effect of the assessment...
January 2024: Neurological Research
https://read.qxmd.com/read/38145566/enriched-environment-enhanced-the-astrocyte-derived-bdnf-and-vegf-expression-and-alleviate-white-matter-injuries-of-rats-with-ischemic-stroke
#32
JOURNAL ARTICLE
Yi-Sha Guo, Xia Bi
OBJECTIVES: Numerous studies have shown that an enriched environment can promote ischemic stroke and improve cognitive function. In addition, white matter is closely related to cognitive function. The effects and mechanisms of the enriched environment on white matter recovery after stroke have not been elucidated. This study will analyse the effects of the enriched environment on white matter and cognitive function in the post-stroke brain from the perspective of astrocytes and their secretions...
December 25, 2023: Neurological Research
https://read.qxmd.com/read/38145565/memory-impairment-induced-by-aluminum-nanoparticles-is-associated-with-hippocampal-il-1-and-iba-1-upregulation-in-mice
#33
JOURNAL ARTICLE
Sadegh Izadi, Maryam Abdolrezaei, Roksana Soukhaklari, Maryam Moosavi
OBJECTIVES: Increasing evidence indicates a link between aluminum (Al) intake and Alzheimer's disease (AD). The main entry of Al into the human body is through oral route, and in the digestive tract, under the influence of the pH change, Al can be transformed into Al nanoparticles (Al-NP). However, studies related to the effect of Al-NP on the brain are limited and need further investigation. Neuro-inflammation is considered as one of the principal features of AD. Microglial activation and expression of the inflammatory cytokine IL-1β (interleukin-1β) in the brain have been used as hallmarks of brain inflammation...
December 25, 2023: Neurological Research
https://read.qxmd.com/read/38122814/minocycline-mitigates-tau-pathology-via-modulating-the-tlr-4-nf-%C3%B0%C2%BA%C3%AE-signalling-pathway-in-the-hippocampus-of-neuroinflammation-rat-model
#34
JOURNAL ARTICLE
Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, Rahimah Zakaria, Idris Long
INTRODUCTION: The neuroinflammatory response was seen to impact the formation of phosphorylated tau protein in Alzheimer's disease (AD). This study aims to investigate the molecular mechanism of minocycline in reducing phosphorylated tau protein formation in the hippocampus of lipopolysaccharide (LPS)-induced rats. METHODS: Fifty adult male Sprague Dawley (SD) rats were randomly allocated to 1 of 5 groups: control, LPS (5 mg/kg), LPS + minocycline (25 mg/kg), LPS + minocycline (50 mg/kg) and LPS + memantine (10 mg/kg)...
December 20, 2023: Neurological Research
https://read.qxmd.com/read/38095353/baseline-serum-brain-derived-neurotrophic-factor-association-with-future-cognition-in-community-dwelling-older-adults-undergoing-annual-memory-screening
#35
JOURNAL ARTICLE
Andrew P Keegan, Con Stough, Daniel Paris, Cheryl A Luis, Laila Abdullah, Ghania Ait-Ghezala, Jillian Chaykin, Fiona Crawford, Michael Mullan
OBJECTIVES: It has been shown that peripheral measures of brain-derived neurotrophic factor (BNDF), an important neurotrophin instrumental to the biology of learning, may contribute to predicting cognitive decline. However, the two primary forms of BDNF, mature (mBDNF) and pro (proBDNF), and how they contribute to cognition longitudinally has not been well studied. METHODS: Eighty-two older adults (average age 72.2 ± 6.4 years) provided blood samples at two time points separated on average by 4...
December 14, 2023: Neurological Research
https://read.qxmd.com/read/38088158/impulsivity-and-attention-deficit-hyperactivity-symptoms-among-patients-with-relapsing-remitting-multiple-sclerosis-a-case-control-study
#36
JOURNAL ARTICLE
Hacer Akgül Ceyhun, Nuray Bilge, Duygu Değirmencioğlu Gök
BACKGROUND AND OBJECTIVES: Multiple sclerosis(MS) is a progressive, autoimmune, neurodegenerative disease.Studies have suggested that autoimmune diseases play a role in the pathogenesis of Attention deficit and hyperactivity disorder(ADHD).We aim to evaluate ADHD symptoms among patients with RRMS(pwRRMS). METHODS: The study included 48 RRMS patients and 54 healthy controls. ADHD symptoms were assessed by self-report questionnaires and performance tests.Beck Depression Inventory (BDI), Turgay's Turkish version of Adult-ADD/ADHD (A-ADHD), Barratt Impulsivity Scale (BIS-11), and World Health Organization Quality of Life-Short Form (WHOQoL-Bref) were completed by the participants...
December 13, 2023: Neurological Research
https://read.qxmd.com/read/37751776/transradial-and-transfemoral-accesses-for-cerebral-angiography-a-retrospective-comparative-study
#37
JOURNAL ARTICLE
Miaomiao Shi, Shuang He
OBJECTIVE: Many large randomized trials in interventional cardiology have shown a significant advantage of transradial access (TRA) over transfemoral access (TFA). However, TRA has yet been widely used in Neurovascular interventional surgery. The purpose of this retrospective comparative study is to compare the effectiveness and safety of transradial and transfemoral accesses for cerebral angiography. METHODS: A total of 380 patients underwent cerebral angiography in our center between January 2019 and January 2021...
December 2023: Neurological Research
https://read.qxmd.com/read/37751764/-in-vivo-anti-epileptic-study-of-newly-synthesized-pregabalin-derivatives-based-on-docking-studies
#38
JOURNAL ARTICLE
Ayesha Asbat, Farooq Saleem, Saima Najm, Javed Iqbal, Muhammad Ali Syed, Muhammad Azeem, Syeda Javeria Asbat, Sadia Shoukat
OBJECTIVE: The goal of the present study is to examine pretreatment with Schiff bases and derivatives of pregabalin along with their metal (Zn and Cu) complexes on the severity of epilepsy, latency time, duration of convulsions, seizure score and survival rate in mice. METHODS: To achieve the goal, a molecular docking study of analogues was carried out on a specific molecular target, such as the alpha-2δ receptor (PDB ID: 6ND9); which revealed the significant binding affinity of the analogs to their respective target...
December 2023: Neurological Research
https://read.qxmd.com/read/37748177/comorbid-conditions-in-egyptian-patients-with-migraine
#39
JOURNAL ARTICLE
Rehab Magdy, Alshimaa S Othman, Eman Hany Elsebaie, Radwa M Elsayed, Walaa Abdelrahman, Suzan Shalaby, Mahmoud Saraya, Sara El-Sayed Abd El-Ghani, Younan Kabara Ayoub, Ahmed Elshall, Alaa Elmazny
BACKGROUND: Identifying migraine comorbidities may guide prognosis and treatment options. This study aimed to assess the frequency of comorbid conditions among adults with migraine living in Greater Cairo. METHODS: In this cross-sectional study, Egyptian migraine sufferers aged ≥ 18 years living in Greater Cairo were consecutively recruited (April 2019 - April 2021). Following The International Classification of Headache Disorders-third edition, diagnosis of migraine was confirmed, and the type of migraine was defined as whether episodic or chronic, with or without aura, with childhood/adolescence or adulthood onset...
December 2023: Neurological Research
https://read.qxmd.com/read/37743634/mild-cognitive-impairment-in-patients-with-parkinson%C3%A2-s-disease-and-the-analysis-of-associated-factors
#40
JOURNAL ARTICLE
Esma Kobak Tur, Buse Cagla Ari
OBJECTIVES: This research targeted to understand the impact of clinical findings, non-motor symptoms, white matter hyperintensities (WMHs), and metabolic features on cognition in Parkinson's disease patients with mild cognitive impairment (PD-MCI). METHODS: Sixty-one PD patients sundered into two groups: PD-MCI and normal cognition (PD-NC). We assessed cognition using Montreal Cognitive Assessment-TR (MoCA-TR) and Frontal Assessment Battery (FAB). We used the modified Hoehn&Yahr staging scale (mH&Y), Unified Parkinson's Disease Rating Scale (UPDRS), Freezing of Gait questionnaire, Beck Depression Inventory, Parkinson's disease sleep scale-2, Pittsburgh sleep quality index, Epworth sleepiness scale, and Non-motor symptoms questionnaire to evaluate all patients...
December 2023: Neurological Research
journal
journal
27636
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.