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Sally L Wootton, Kylie Hill, Jennifer A Alison, Li Whye Cindy Ng, Sue Jenkins, Peter R Eastwood, David R Hillman, Christine Jenkins, Lissa M Spencer, Nola Cecins, Zoe J McKeough
This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care group (UCG). During the maintenance program, the IG received ongoing feedback (telephone calls, biofeedback provided via pedometer and progressive goal setting) and the UCG received no feedback...
April 15, 2019: Lung
Justin Karush, Andrew Arndt, Palmi Shah, Nicole Geissen, Linda Dowling, Ashley Levitan, Gary Chmielewski, Christopher Seder, Michael Liptay
BACKGROUND: Concern over high false-positive rates and the potential for unintended harm to patients is a critical component of the lack of widespread adoption of lung cancer screening. METHODS: An institutional database was used to identify patients who underwent lung cancer screening between 2/2015 and 2/2018 at Rush University Medical Center and Rush Oak Park Hospital. Reads were executed by dedicated thoracic radiologists and communicated using the Lung Imaging Reporting and Data System (Lung-RADS V...
April 12, 2019: Lung
M Voortman, C M R Hendriks, M D P Elfferich, F Bonella, J Møller, J De Vries, U Costabel, M Drent
The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name "M.D." for coauthor M.D.P. Elfferich's name has been inadvertently deleted during the production process.
April 8, 2019: Lung
Charlotte Berlier, Esther I Schwarz, Stéphanie Saxer, Mona Lichtblau, Silvia Ulrich
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) and distal chronic thromboembolic pulmonary hypertension (CTEPH) who still reveal risk factors of worse prognosis on double combination therapy may benefit from add-on therapy with the novel oral selective prostacyclin receptor agonist selexipag. METHODS: We reviewed all patients with PAH/distal CTEPH in the Zurich cohort who received selexipag as add-on to oral combination therapy and retrieved New York Heart Association (NYHA) functional class, 6-min walk distance (6MWD), NT-pro-BNP, quality of life questionnaires (CAMPHOR and EuroQoL), tricuspid pressure gradient (TPG) by echocardiography and cardiopulmonary exercise test parameters (power output and oxygen uptake)...
April 8, 2019: Lung
A M O'Mahony, G M Murphy, M T Henry
No abstract text is available yet for this article.
April 5, 2019: Lung
Filippo Lococo, Teresa Di Stefano, Cristian Rapicetta, Roberto Piro, Maria Carolina Gelli, Francesco Muratore, Tommaso Ricchetti, Sofia Taddei, Maurizio Zizzo, Alfredo Cesario, Nicola Facciolongo, Massimiliano Paci
We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). With the suspicious of a pleural mesothelioma, a CT-scan before and a 18F -FDG PET/CT-scan later were performed revealing multiple pleural thickenings and multiple mediastinal lymphadenopathies with radiotracer uptake...
April 2, 2019: Lung
Dirk Rades, Heinke C Hansen, Steven E Schild, Stefan Janssen
INTRODUCTION: Personalized treatment helps one achieve optimal outcomes in patients with non-small cell lung cancer (NSCLC). Understanding patients' survival prognoses in a palliative situation like intracerebral metastases is critical. A new survival score, the WBRT-30-NSCLC, was developed for patients with intracerebral metastases from NSCLC. METHODS: Eight factors were investigated in 157 patients receiving 10 × 3 Gy of whole-brain radiotherapy (WBRT) including age, gender, Karnofsky performance score (KPS), interval from diagnosis of NSCLC to WBRT, pre-WBRT systemic treatment, primary tumor control, number of intracerebral metastases, and metastasis outside the brain...
March 29, 2019: Lung
David Bennett, Paola Rottoli, Natale Figura
No abstract text is available yet for this article.
March 21, 2019: Lung
Bruno Hochhegger, Felipe W Langer, Klaus Irion, Arthur Souza, José Moreira, Matteo Baldisserotto, Yana Pallaoro, Enrico Muller, Tassia Machado Medeiros, Stephan Altmayer, Edson Marchiori
The lung acinus is the most distal portion of the airway responsible for the gas exchange. The normal acini are not visible on conventional computed tomography (CT), but the advent of micro-CT improved the understanding of the microarchitecture of healthy acini. The comprehension of the acinar architecture is pivotal for the understanding of CT findings of diseases that involve the acini. Centriacinar emphysema, for example, presents as round areas of low attenuation due to the destruction of the most central acini with compensatory enlargement of proximal acini due to alveolar wall destruction...
March 21, 2019: Lung
Peter S P Cho, Sharmila Vasudevan, Matthew Maddocks, Arietta Spinou, Sarah Chamberlain Mitchell, Claire Wood, Caroline J Jolley, Surinder S Birring
PURPOSE: Reduced physical activity in many chronic diseases is consistently associated with increased morbidity. Little is known about physical activity in sarcoidosis. The aim of this study was to objectively assess physical activity in patients with pulmonary sarcoidosis and investigate its relationship with lung function, exercise capacity, symptom burden, and health status. METHODS: Physical activity was assessed over one week in 15 patients with pulmonary sarcoidosis and 14 age-matched healthy controls with a tri-axial accelerometer (ActivPal™) and the International Physical Activity Questionnaire (IPAQ)...
March 19, 2019: Lung
Mariana Carneiro Lopes, Thaís Porto Amadeu, Marcelo Ribeiro-Alves, Claudia Henrique da Costa, Luciana Silva Rodrigues, Elisabeth Jauhar Cardoso Bessa, Leonardo Palermo Bruno, Agnaldo José Lopes, Rogerio Rufino
PURPOSE: Activity/remission differentiation is a great challenge in the follow-up and treatment of sarcoidosis patients. Angiotensin-converting enzyme (ACE) and high sensitivity C-reactive protein (hs-CRP) were proposed as sarcoidosis biomarkers. More recently, chitotriosidase (CHITO) has been described as a better alternative. This study has the aim to evaluate the association of CHITO activity, ACE, hs-CRP or a combination of these biomarkers and to construct a clinical algorithm to differentiate between sarcoidosis activity/remission status...
March 19, 2019: Lung
Moshe Ashkenazi, N Nathan, I Sarouk, B E Bar Aluma, A Dagan, Y Bezalel, S Keler, D Vilozni, O Efrati
INTRODUCTION: There is a strong association between cystic fibrosis and malnutrition, mainly because of the higher energy needs combined with lower intake. There is also a well-established correlation between good nutritional status and better lung function. To date, however, there are no studies examining nutritional status in childhood and adult lung function. To respond to this need, this innovative study explored the long-term correlations between nutritional status in childhood and lung function in adulthood for the same patient population...
March 18, 2019: Lung
Rafik Belhaj, Wajih Kaabachi, Ikbel Khalfallah, Basma Hamdi, Kamel Hamzaoui, Agnes Hamzaoui
INTRODUCTION: Asthma is a common respiratory childhood disease that results from an interaction between genetic, environmental and immunologic factors. The implication of nucleotide-binding and oligomerization domain 1 and 2 (NOD1/CARD4, NOD2/CARD15) was highlighted in many inflammatory diseases. METHODS: In this case-control study, we analyzed the association of three NOD2 polymorphisms and one NOD1 variant, in 338 Tunisian asthmatic children and 425 healthy Controls, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method...
March 14, 2019: Lung
Young Seok Lee, Kyung Hoon Min, Chin Kook Rhee, Yong Hyun Kim, Seong Yong Lim, Soo-Jung Um, Chang-Hoon Lee, Ki-Suck Jung, Kwang Ha Yoo
PURPOSE: The economic effect of regular follow-up and early management in patients with early chronic obstructive pulmonary disease (COPD) has not yet been clarified. Therefore, this study aimed to estimate the economic effect of regular follow-up and early management in these patients. METHODS: Patients with early COPD were identified from the Korea National Health and Nutrition Examination Survey. We analyzed medical utilization and cost for 2 years without any missing data by using the Korean National Health Insurance data...
March 11, 2019: Lung
Lee Fidler, Irena Doubelt, Sonja Kandel, Jolene H Fisher, Shikha Mittoo, Shane Shapera
PURPOSE: International guidelines recommend screening for connective tissue disease (CTD) with autoantibodies when evaluating patients with idiopathic interstitial lung disease (ILD). Idiopathic inflammatory myositis comprises of a subgroup of CTD diagnosed with myositis antibodies (MA), often presenting with ILD. Our aim was to evaluate the utility of MA screening in patients with idiopathic ILD. METHODS: A retrospective analysis was conducted on patients referred with idiopathic ILD to a tertiary centre ILD clinic who were screened for MA...
March 5, 2019: Lung
Lars Hagmeyer, Jana Fassunke, Marianne Engels, Marcel Treml, Simon Herkenrath, Sandhya Matthes, Reinhard Büttner, Winfried Randerath
The role of bronchoscopic brushing for tumor detection and molecular testing in central lung cancer is unclear. In this study, 50 consecutive subjects with suspected central lung cancer underwent bronchoscopic brushing (31 males, median age 70, 5 never smokers). Histological results were: NSCLC/SCLC/low-grade-NET/granulation tissue in 36/8/2/4 cases. Next generation sequencing (NGS) was feasible in 62% of tumor-positive brush smear samples. In 78% of these cases, NGS displayed identical results compared to histology samples, in 22% NGS from brush smears detected specific mutations, whereas DNA quality from forceps biopsy was insufficient for NGS analysis...
March 1, 2019: Lung
Renáta M Böcskei, Béla Benczúr, György Losonczy, Miklós Illyés, Attila Cziráki, Veronika Müller, Anikó Bohács, András Bikov
INTRODUCTION: Soluble urokinase-type plasminogen activator receptor (suPAR) is upregulated by inflammation and plays a role in the pathogenesis of atherosclerosis. Chronic obstructive pulmonary disease (COPD) is associated with enhanced systemic inflammation and increased risk for atherosclerosis, however, studies analysing the circulating suPAR levels in COPD are contradictory. The aim of the study was to investigate plasma suPAR concentrations together with markers of arterial stiffness in COPD...
February 28, 2019: Lung
Patompong Ungprasert, Karn Wijarnpreecha, Wisit Cheungpasitporn, Charat Thongprayoon, Wuttiporn Manatsathit, Paul T Kröner
PURPOSE: To investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA. METHODS: Patients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient and hospital characteristics, comorbidities, total hospital costs, and total hospitalization charges were collected. A propensity-matched cohort of patients without sarcoidosis from the same database was created and used as comparators for the analysis of comorbidities...
February 23, 2019: Lung
Federica De Giacomi, Narat Srivali
No abstract text is available yet for this article.
February 20, 2019: Lung
Bryan S Benn, Mihir Parikh, Pei H Tsau, Eric Seeley, Ganesh Krishna
PURPOSE: While there is significant mortality and morbidity with lung cancer, early stage diagnoses carry a better prognosis. As lung cancer screening programs increase with more pulmonary nodules detected, expediting definitive treatment initiation for newly diagnosed patients is imperative. The objective of our analysis was to determine if the use of a dedicated interventional pulmonology practice decreases time delay from new diagnosis of lung cancer or metastatic disease to the chest to treatment initiation...
February 19, 2019: Lung
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