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Sung-Yoon Kang, Ha-Kyeong Won, Sang Min Lee, Jae-Woo Kwon, Min-Hye Kim, Eun-Jung Jo, Seung-Eun Lee, Sae-Hoon Kim, Yoon-Seok Chang, Sang Pyo Lee, Byung-Jae Lee, Sang-Heon Cho, Surinder S Birring, Woo-Jung Song
PURPOSE: Chronic cough is a common problem in various populations. The present study assessed the impact of cough and unmet needs in Korean patients with chronic cough. METHODS: This cross-sectional multi-center study enrolled adult patients newly referred to clinic for assessment of chronic cough. A second group of patients with unexplained chronic cough following detailed assessment were recruited for comparison. Patients completed self-reported questionnaires, including cough characteristics, impact of cough on daily life, and unmet needs...
August 16, 2019: Lung
Majid Shafiq, Elizabeth Thompson, Peter Illei, Lonny Yarmus
No abstract text is available yet for this article.
August 10, 2019: Lung
Chongxu Zhang, Renzhi Cai, Aaron Lazerson, Gaetan Delcroix, Medhi Wangpaichitr, Mehdi Mirsaeidi, Anthony J Griswold, Andrew V Schally, Robert M Jackson
PURPOSE: Growth hormone-releasing hormone (GHRH) is a 44-amino acid peptide that regulates growth hormone (GH) secretion. We hypothesized that a GHRH receptor (GHRH-R) antagonist, MIA-602, would inhibit bleomycin-induced lung inflammation and/or fibrosis in C57Bl/6J mice. METHODS: We tested whether MIA-602 (5 μg or vehicle given subcutaneously [SC] on days 1-21) would decrease lung inflammation (at day 14) and/or fibrosis (at day 28) in mice treated with intraperitoneal (IP) bleomycin (0...
August 7, 2019: Lung
Buğra Kerget, Omer Araz, Haktan Bağış Erdem, Metin Akgün
PURPOSE: In obstructive sleep apnea syndrome (OSAS) many proinflammatory cytokines are released from activated endothelial cells due to repeated decreases in arterial oxygen saturation. Some of these proinflammatory cytokines are involved in the etiology of coronary artery disease (CAD). Although the association between OSAS and CAD is known, risk factors for CAD have not been determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a proinflammatory cytokine that plays a key role in the development of atherosclerosis...
August 6, 2019: Lung
Juan Li, Song Yang, Xiaolu Jiao, Yunyun Yang, Haili Sun, Ming Zhang, Yunxiao Yang, Yanwen Qin, Yongxiang Wei
PURPOSE: Obstructive sleep apnea (OSA) is a common sleep disorder that is influenced by various environmental and genetic factors. The potential associations of leptin and leptin receptor (LEPR) polymorphisms with OSA have been studied in different populations; however, the results remain inconclusive. The aim of this study was to examine the association between LEPR gene polymorphisms and OSA risk. METHODS: A total of 322 samples were used, including 226 OSA subjects and 96 controls...
August 1, 2019: Lung
Mitchell S von Itzstein, Arjun Gupta, Kristin C Mara, Sahil Khanna, David E Gerber
INTRODUCTION: The use of molecular biomarkers to guide lung cancer management has led to increasing frequency and amounts of tissue required for repeat lung biopsies. While patient safety and reporting of adverse events has been increasingly emphasized in recent decades, the safety of lung biopsies in patients with lung cancer has only been studied in small cohorts. We therefore analyzed adverse events in patients with lung cancer undergoing lung biopsies in the National Hospital Discharge Survey (NHDS) database...
July 31, 2019: Lung
Adonis A Protopapas, Stergios Vradelis, Theodoros Karampitsakos, Paschalis Steiropoulos, Athanasios Chatzimichael, Emmanouil Paraskakis
INTRODUCTION: Pulmonary manifestations of inflammatory bowel disease (IBD), albeit not rare, are largely overlooked in clinical practice. The role of exhaled nitric oxide (eNO) as an established biological marker of airway inflammation compels us to use it as a tool to investigate the exact nature of these manifestations. METHODS: Fractional eNO (FeNO) was measured in multiple flows, and with the use of a mathematical model, alveolar concentration of NO (CA NO) and bronchial flux of NO (Jaw NO) were assessed in 27 patients with IBD [17 with Crohn's disease (CD) and 10 with ulcerative colitis (UC)] and in 39 healthy controls...
July 17, 2019: Lung
Alison S F Elder, Andrew D Bersten, Gino T P Saccone, Claudine S Bonder, Dani-Louise Dixon
PURPOSE: Mechanical ventilation is a well-established therapy for patients with acute respiratory failure. However, up to 35% of mortality in acute respiratory distress syndrome may be attributed to ventilation-induced lung injury (VILI). We previously demonstrated the efficacy of the synthetic tripeptide feG for preventing and ameliorating acute pancreatitis-associated lung injury. However, as the mechanisms of induction of injury during mechanical ventilation may differ, we aimed to investigate the effect of feG in a rodent model of VILI, with or without secondary challenge, as a preventative treatment when administered before injury (prophylactic), or as a therapeutic treatment administered following initiation of injury (therapeutic)...
July 12, 2019: Lung
A Sugitani, K Asai, T Watanabe, T Suzumura, K Kojima, H Kubo, K Sato, N Ijiri, K Yamada, T Kimura, S Fukumoto, K Hirata, T Kawaguchi
INTRODUCTION: Several studies have reported that single nucleotide polymorphisms (SNPs) in the gene encoding NF-E2-related factor 2 (Nrf2) contribute to airflow limitations in smokers without COPD. Although small airway lesions and emphysema contribute cooperatively to airflow limitation, the relationship between Nrf2 SNPs and the development of emphysema in smokers without COPD is not well understood. METHODS: Healthy subjects who underwent an annual health checkup with computed tomography (CT) of the chest at Osaka City University Hospital were prospectively recruited...
July 11, 2019: Lung
Chris RuiWen Kuo, Sunny Jabbal, Brian Lipworth
BACKGROUND: The forced oscillation technique (FOT) measures respiratory impedance during normal tidal breathing and requires minimal patient cooperation. OBJECTIVE: To compare IOS and AOS devices in patients with asthma and COPD. METHODS: We compared two different FOT devices, namely impulse oscillometry using a loudspeaker (IOS: Jaeger Masterscreen) and airwave oscillometry using a vibrating mesh (AOS: Thorasys Tremoflo) for pre- and post-bronchodilator measurements in 84 patients with asthma and COPD...
July 4, 2019: Lung
Carmina Jiménez-Ramírez, Swaantje Casjens, Cuauhtémoc Arturo Juárez-Pérez, Irina Raiko, Luz M Del Razo, Dirk Taeger, Emma S Calderón-Aranda, Hans-Peter Rihs, Leonor Concepción Acosta-Saavedra, Daniel Gilbert Weber, Alejandro Cabello-López, Beate Pesch, María Dolores Ochoa-Vázquez, Katarzyna Burek, Luis Torre-Bouscoulet, José Rogelio Pérez-Padilla, Erik Marco García-Bazan, Thomas Brüning, Georg Johnen, Guadalupe Aguilar-Madrid
PURPOSE: Malignant pleural mesothelioma (MPM) is a highly lethal cancer caused by exposure to asbestos. Currently, the diagnosis is a challenge, carried out by means of invasive methods of limited sensitivity. This is a case-control study to evaluate the individual and combined performance of minimally invasive biomarkers for the diagnosis of MPM. METHOD: A study of 166 incident cases of MPM and 378 population controls of Mestizo-Mexican ethnicity was conducted...
July 2, 2019: Lung
Stéphanie Saxer, Mona Lichtblau, Charlotte Berlier, Elisabeth D Hasler, Esther I Schwarz, Silvia Ulrich
INTRODUCTION: The cardinal symptom of pulmonary hypertension (PH) is dyspnea on exertion, leading to decreased activity in daily living. The aim of this study was to analyze daily physical activity in incident patients with arterial or chronic thromboembolic PH (PAH/CTEPH) and to investigate its correlation with pulmonary hemodynamics, symptoms, exercise capacity, and other outcomes. METHODS: Incident patients with PAH/CTEPH had a 1-week activity assessment by the arm-worn accelerometer SenseWear within - 3 months/+ 2 weeks of the diagnostic right heart catheterization (RHC) and baseline assessments including 6-minute walking distance (6MWD)...
July 1, 2019: Lung
Gareth I Walters, P Sherwood Burge, Adeel Sahal, Alastair S Robertson, Vicky C Moore
PURPOSE: Occupational exposures are a common cause of adult-onset asthma; rapid removal from exposure to the causative agent offers the best chance of a good outcome. Despite this, occupational asthma (OA) is widely underdiagnosed. We aimed to see whether chances of diagnosis were missed during acute hospital attendances in the period between symptom onset and the diagnosis of OA. METHODS: Patients diagnosed with OA at the regional occupational lung disease service in Birmingham between 2007 and 2018 whose home address had a Birmingham postcode were included...
June 29, 2019: Lung
Hua-Shai Hsu, Sung-Lin Hu, Chun-Ru Chien
No abstract text is available yet for this article.
June 29, 2019: Lung
Rafael E de la Hoz, Xiaoyu Liu, Juan C Celedón, John T Doucette, Yunho Jeon, Anthony P Reeves, Raúl San José Estépar
BACKGROUND: We previously reported that wall area percent (WAP), a quantitative CT (QCT) indicator of airway wall thickness and, presumably, inflammation, is associated with adverse longitudinal expiratory flow trajectories in WTC workers, but that obesity and weight gain also seemed to be independently predictive of the latter. Previous studies have reported no association between WAP and obesity, so we investigated that association in nonsmoking WTC-exposed individuals and healthy unexposed controls...
June 28, 2019: Lung
Tomoya Sagawa, Takashi Kida, Tohru Inaba, Isao Yokota, Risa Sagawa, Akiko Kasahara, Shunya Kaneshita, Takuya Inoue, Hidetake Nagahara, Kazuki Fujioka, Makoto Wada, Masataka Kohno, Yutaka Kawahito
We aimed to evaluate the utility of coagulation markers for the prediction of rapidly progressive interstitial lung disease (RP-ILD) in patients with dermatomyositis (DM). In this retrospective study, 29 patients with DM-associated ILD were analyzed. The number of patients with RP-ILD was 15 (52%). The baseline clinical and demographic data and laboratory markers were analyzed to identify predictive factors for RP-ILD.The univariate logistic regression analysis demonstrated that in addition to well-known laboratory markers, such as serum ferritin, KL-6, and lymphocyte counts, a prolonged activated partial thromboplastin time (aPTT) ratio at the time of DM-associated ILD diagnosis was useful for predicting RP-ILD...
June 25, 2019: Lung
Aleksandra Barac, Hannah Karimzadeh-Esfahani, Mahya Pourostadi, Mohammad Taghi Rahimi, Ehsan Ahmadpour, Jalil Rashedi, Behroz Mahdavipoor, Hossein Samadi Kafil, Adel Spotin, Kalkidan Hassen Abate, Alexander G Mathioudakis, Mohammad Asgharzadeh
BACKGROUND: Microbiological cultures are the mainstay of the diagnosis of tuberculosis (TB). False-positive TB results lead to significant unnecessary therapeutic and economic burden and are frequently caused by laboratory cross-contamination. The aim of this meta-analysis was to quantify the prevalence of laboratory cross-contamination. METHODS: Through a systematic review of five electronic databases, we identified studies reporting rates of laboratory cross-contamination, confirmed by molecular techniques in TB cultures...
June 15, 2019: Lung
Manuel Ramos-Casals, Belchin Kostov, Pilar Brito-Zerón, Antoni Sisó-Almirall, Robert P Baughman
BACKGROUND: Sarcoidosis is a systemic disease in which the personal environment seems to drive a differentiated disease frequency and clinical expression. The main epidemiological studies suggest a key influence of potential environmentally linked exposures related to the type of occupation, the household, life style, socioeconomic status, and region of residence. OBJECTIVE: To provide an update on how sarcoidosis may be modulated by environmental factors. DATA SOURCES: We searched PubMed for epidemiological studies...
June 12, 2019: Lung
Seo Am Hur, Sabina A Guler, Nasreen Khalil, Pat G Camp, Jordan A Guenette, Christopher J Ryerson
PURPOSE: The impact of psychological deficits and pain on physical activity has not been adequately studied in patients with fibrotic interstitial lung disease (ILD). We aimed to determine the association of depression, anxiety, sleep quality, and pain with physical activity in fibrotic ILD. METHODS: Waist ActiGraph activity monitors were worn for seven consecutive days to track step counts and moderate-to-vigorous physical activity (MVPA) minutes at baseline and 6-month follow-up...
June 1, 2019: Lung
Sameep Sehgal, Ananda Chowdhury, Fadi Rabih, Abhishek Gadre, Margaret M Park, Manshi Li, Xiaofeng Wang, Kristin B Highland
RATIONALE: Activity levels in patients with pulmonary arterial hypertension (PAH) have correlated with surrogate markers of disease severity. It is not known whether physical activity measures are useful in monitoring patients with PAH. OBJECTIVES: This pilot study aimed to evaluate whether change in physical activity measured by an accelerometer correlates with changes in six-minute walk distance (6MWD), echocardiographic parameters, NT-proBNP, or health-related quality-of-life measures (HRQOL)...
May 29, 2019: Lung
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