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Laura Núñez-Naveira, Luis Antonio Mariñas-Pardo, Carmen Montero-Martínez
INTRODUCTION: New sampling techniques to analyse lung diseases, such as exhaled breath condensate (EBC), are a breakthrough in research field since they are less invasive and less traumatic for the patients compared to lung biopsies. Nevertheless, there is an increasing need to optimize not only the sampling protocols but the storage and processing of specimens to get accurate results. METHODS: Exhaled breath condensate was sampled employing the ECoScreen device...
May 21, 2019: Lung
C M R Hendriks, L A Saketkoo, M D P Elfferich, J De Vries, P A H M Wijnen, M Drent
OBJECTIVE: Sarcoidosis, an inflammatory multi-organ disease with a wide variety of clinical manifestations, affecting people of working age. Patients suffer from a broad spectrum of physical symptoms of varying severity that impact function including cognitive impairment and disabling fatigue. The Dutch Sarcoidosis Society identified a knowledge gap in various facets related to work ability. The aim of this study was to assess sarcoidosis patients' perceived problems related to work performance, employer, and disability evaluations...
May 17, 2019: Lung
Abigel M Kolonics-Farkas, Bence Agg, Kalman Benke, Balazs Odler, Aniko Bohacs, Zsuzsanna Kovats, Zoltan Szabolcs, Veronika Müller
INTRODUCTION: Marfan syndrome is a genetic disorder affecting the connective tissue. Changes in lung tissue might influence respiratory function; however, a detailed respiratory functional assessment according to the need for major thoracic surgery is missing. METHODS: Comprehensive pulmonary examinations were performed in 55 Marfan patients including respiratory symptoms, lung function (LF) testing using European Coal and Steel Community (ECSC) reference values, TLCO and quality of life measurements...
May 14, 2019: Lung
N T Ayas, A J Hirsch Allen, N Fox, B Peres, M Mehrtash, K H Humphries, R Jen, C M Taylor, S F van Eeden
PURPOSE: Patients with obstructive sleep apnea (OSA) are at increased risk of cardiovascular and cerebrovascular disease (CVD) but it is unclear who are at greatest risk. We determined whether the inflammatory marker, C-reactive protein (CRP), could be a useful prognostic biomarker. METHODS: Adult patients referred for polysomnography (PSG) with OSA were studied. Serum CRP levels were measured using ELISA the morning after PSG. Validated CV events within 4 years of PSG were ascertained by linking to provincial research datasets...
May 14, 2019: Lung
Letícia Fernandes Belo, Antenor Rodrigues, Thaís Paes, Felipe Vilaça Cavallari Machado, Lorena Paltanin Schneider, Ana Paula Vicentin, Vanessa Suziane Probst, Fabio Pitta, Nidia Aparecida Hernandes
PURPOSE: Whether the difference in the impact of chronic obstructive pulmonary disease (COPD) on the functional status of men and women stems from clinical distinctions or to the measuring instrument used is unclear. Like most instruments for assessing functional limitation in COPD, the interpretation of the results of the London Chest Activity of Daily Living (LCADL) scale is limited because a lack of a valid cutoff point to this scale. For that, this study sought to compare the functional status between men and women with COPD; and propose a cutoff point for LCADL capable of discriminating the prognosis of these individuals...
May 11, 2019: Lung
Ricardo L M Duarte, Flavio J Magalhães-da-Silveira, Tiago S Oliveira-E-Sá, Marcelo F Rabahi, Fernanda C Q Mello, David Gozal
PURPOSE: Obstructive sleep apnea (OSA) and insomnia are very prevalent disorders, especially in sleep-lab setting, and insomnia may be the presenting complaint of OSA. Here, we aimed to validate No-Apnea as screening tool for OSA in patients with self-reported insomnia complaints and to compare its performance with other models. METHODS: This cross-sectional study involved evaluation of No-Apnea as well as STOP-Bang, NoSAS and Epworth Sleepiness Scale (ESS) in subjects with insomnia being evaluated with full in-lab polysomnography...
May 10, 2019: Lung
Imran H Iftikhar, Meredith Greer, Ahmadu Jaiteh
INTRODUCTION: Exercise-induced bronchoconstriction (EIB) is very common in athletes. Cardiopulmonary exercise tests (CPET) have traditionally been used for the diagnosis of EIB. However, alternative indirect bronchoprovocation tests have recently been used as surrogate tests. One of these is the eucapnic voluntary hyperventilation (EVH). This meta-analysis studied the agreement between the two tests. METHODS: An extensive search in PubMed and Medline was conducted for studies where participants underwent both CPET and EVH with measurement of forced expiratory volume in 1-second (FEV1 )...
May 10, 2019: Lung
Vandy P Stober, Yow-Pin Lim, Steven Opal, Lisheng Zhuo, Koji Kimata, Stavros Garantziotis
PURPOSE: Vascular endothelial cells demonstrate severe injury in sepsis, and a reduction in endothelial inflammation would be beneficial. Inter-α-Inhibitor (IαI) is a family of abundant plasma proteins with anti-inflammatory properties and has been investigated in human and animal sepsis with encouraging results. We hypothesized that IαI may protect endothelia from sepsis-related inflammation. METHODS: IαI-deficient or sufficient mice were treated with endotoxin or underwent complement-induced lung injury...
April 26, 2019: Lung
Ruohan Li, Jingjing Zhang, Ya Gao, Jiamei Li, Bin Yan, Gang Wang
PURPOSE: To investigate whether lung function, especially when complicated with SDB, has an increased risk for myocardial infarction (MI) and congestive heart failure (CHF). METHODS: A prospective study was performed within the Sleep Heart Health Study (SHHS). A total of 4161 individuals were followed up for an average of 10.91 years. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1 ) and the predicted value of FVC and FEV1 were measured to evaluate lung function...
April 25, 2019: Lung
Imran H Iftikhar, Stephanie Teng, Mathew Schimmel, Crystal Duran, Alejandro Sardi, Shaheen Islam
BACKGROUND: Several different tracheostomy techniques (percutaneous and surgical) have been studied extensively in previous direct pairwise meta-analyses. However, a network comparative meta-analysis comparing all has not been conducted before. OBJECTIVE: We sought to compare three percutaneous dilatational tracheostomy techniques with open surgical tracheostomy technique (performed in the operating room or in the intensive care unit by bedside) in terms of their association with procedure-related major complications and procedure time...
April 24, 2019: Lung
Mateo Tole, Stephanie LaBedz, Douglas L Feinstein, Israel Rubinstein
A large-scale outbreak of life-threatening, inhaled synthetic cannabinoids (Spice/K2)-associated coagulopathy with bleeding complications was recently reported in Illinois. The causative agents were brodifacoum, difenacoum, and bromadiolone, potent, long-acting, 4-hydroxycoumarin anticoagulant rodenticides (LAAR) that were mixed with Spice/K2 products procured and then inhaled by the victims. We report on 3 poisoned patients who reside in underserved, socioeconomically disadvantaged neighborhoods of Chicago that were admitted and treated successfully at two inner-city, tertiary care hospitals in Chicago...
April 19, 2019: Lung
Sally L Wootton, Kylie Hill, Jennifer A Alison, Li Whye Cindy Ng, Sue Jenkins, Peter R Eastwood, David R Hillman, Christine Jenkins, Lissa M Spencer, Nola Cecins, Zoe J McKeough
This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care group (UCG). During the maintenance program, the IG received ongoing feedback (telephone calls, biofeedback provided via pedometer and progressive goal setting) and the UCG received no feedback...
April 15, 2019: Lung
Justin Karush, Andrew Arndt, Palmi Shah, Nicole Geissen, Linda Dowling, Ashley Levitan, Gary Chmielewski, Christopher Seder, Michael Liptay
BACKGROUND: Concern over high false-positive rates and the potential for unintended harm to patients is a critical component of the lack of widespread adoption of lung cancer screening. METHODS: An institutional database was used to identify patients who underwent lung cancer screening between 2/2015 and 2/2018 at Rush University Medical Center and Rush Oak Park Hospital. Reads were executed by dedicated thoracic radiologists and communicated using the Lung Imaging Reporting and Data System (Lung-RADS V...
April 12, 2019: Lung
M Voortman, C M R Hendriks, M D P Elfferich, F Bonella, J Møller, J De Vries, U Costabel, M Drent
The original version of this article unfortunately contained a mistake in coauthor's given name. The abbreviated given name "M.D." for coauthor M.D.P. Elfferich's name has been inadvertently deleted during the production process.
April 8, 2019: Lung
Charlotte Berlier, Esther I Schwarz, Stéphanie Saxer, Mona Lichtblau, Silvia Ulrich
BACKGROUND: Patients with pulmonary arterial hypertension (PAH) and distal chronic thromboembolic pulmonary hypertension (CTEPH) who still reveal risk factors of worse prognosis on double combination therapy may benefit from add-on therapy with the novel oral selective prostacyclin receptor agonist selexipag. METHODS: We reviewed all patients with PAH/distal CTEPH in the Zurich cohort who received selexipag as add-on to oral combination therapy and retrieved New York Heart Association (NYHA) functional class, 6-min walk distance (6MWD), NT-pro-BNP, quality of life questionnaires (CAMPHOR and EuroQoL), tricuspid pressure gradient (TPG) by echocardiography and cardiopulmonary exercise test parameters (power output and oxygen uptake)...
April 8, 2019: Lung
A M O'Mahony, G M Murphy, M T Henry
No abstract text is available yet for this article.
April 5, 2019: Lung
Filippo Lococo, Teresa Di Stefano, Cristian Rapicetta, Roberto Piro, Maria Carolina Gelli, Francesco Muratore, Tommaso Ricchetti, Sofia Taddei, Maurizio Zizzo, Alfredo Cesario, Nicola Facciolongo, Massimiliano Paci
We report a rare case of a IgG4-related disease presenting with recurrent pleural effusion, pleural thickness and multiple mediastinal lymphadenopathies and no involvement of other extrathoracic organs. A 65-year-old man with a previous asbestos exposure presented with cough and pain discomfort. A large right pleural effusion was detected and evacuated (siero-haematic liquid). With the suspicious of a pleural mesothelioma, a CT-scan before and a 18F -FDG PET/CT-scan later were performed revealing multiple pleural thickenings and multiple mediastinal lymphadenopathies with radiotracer uptake...
April 2, 2019: Lung
Dirk Rades, Heinke C Hansen, Steven E Schild, Stefan Janssen
INTRODUCTION: Personalized treatment helps one achieve optimal outcomes in patients with non-small cell lung cancer (NSCLC). Understanding patients' survival prognoses in a palliative situation like intracerebral metastases is critical. A new survival score, the WBRT-30-NSCLC, was developed for patients with intracerebral metastases from NSCLC. METHODS: Eight factors were investigated in 157 patients receiving 10 × 3 Gy of whole-brain radiotherapy (WBRT) including age, gender, Karnofsky performance score (KPS), interval from diagnosis of NSCLC to WBRT, pre-WBRT systemic treatment, primary tumor control, number of intracerebral metastases, and metastasis outside the brain...
March 29, 2019: Lung
David Bennett, Paola Rottoli, Natale Figura
No abstract text is available yet for this article.
March 21, 2019: Lung
Bruno Hochhegger, Felipe W Langer, Klaus Irion, Arthur Souza, José Moreira, Matteo Baldisserotto, Yana Pallaoro, Enrico Muller, Tassia Machado Medeiros, Stephan Altmayer, Edson Marchiori
The lung acinus is the most distal portion of the airway responsible for the gas exchange. The normal acini are not visible on conventional computed tomography (CT), but the advent of micro-CT improved the understanding of the microarchitecture of healthy acini. The comprehension of the acinar architecture is pivotal for the understanding of CT findings of diseases that involve the acini. Centriacinar emphysema, for example, presents as round areas of low attenuation due to the destruction of the most central acini with compensatory enlargement of proximal acini due to alveolar wall destruction...
March 21, 2019: Lung
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