Experimental Aging Research

OBJECTIVE: The purpose of this study was to assess the association between serum 25-hydroxyvitamin D [25(OH)D] levels and depressive symptoms in Mexican older adults 70 years and older. METHODS: A total of 326 adults aged 70 or older from Coyoacán Cohort Study were included in this study. The depressive symptoms were assessing by Center for Epidemiologic Studies Depression Scale (CES-D) and serum 25-hydroxyvitamin D [25(OH)D] levels were measured by commercially available enzyme-linked immunosorbent assay (ELISA)...

INTRODUCTION: Age simulation suits are increasingly used in health care education. However, empirical evidence that quantifies the simulated performance losses in established geriatric tests and compares those declines with reference data of older adults is scarce. METHODS: In a standardized lab setting, we compared performance of N  = 61 participants (46 middle-aged, 15 young adults) with and without age simulation suit, for example in the Timed Up and Go Test (+dual task), Short Physical Performance Battery, grip strength, and 30-Second-Chair- Standing Test...

OBJECTIVE: The aim of the current study was to investigate affective personality traits in Alzheimer's disease, a neurodegenerative condition mainly characterized by episodic memory impairment. METHOD: The sample included 69 participants from 3 diagnostic categories. Twenty-five participants were diagnosed with subjective cognitive impairment (SCI), 26 participants were diagnosed with mild cognitive impairment of the amnestic type (aMCI), and the remaining 18 participants were diagnosed with early-stage Alzheimer's dementia (ADD)...

A lifetime of resilience through emotionally challenging experiences may benefit older adults, lending to emotion regulation mastery with time. Yet the influence of autobiographical experiences on momentary reappraisal, the reinterpretation of negative stimuli as more positive, has never been empirically tested. This online study examined the extent to which associating life memories of resilience with novel negative scenarios enhanced reappraisal efficacy and reduced difficulty to reappraise. Younger and older adults reappraised negative images by associating reappraisals to freely selected autobiographical resilience memories, cued autobiographical resilience memories, or by finding situational silver linings without mnemonic association (control)...

In this study, I investigated the role of distraction on arithmetic performance and whether this role changes with aging during adulthood. Young and older adults were asked to verify one-digit addition problems (Expt. 1) or to estimate the results of two-digit multiplication problems (Expt. 2). In both experiments, true and false simple problems (Expt. 1) or easier and harder complex problems (Expt. 2) were displayed superimposed or not on irrelevant, emotionally neutral pictures (e.g. mushrooms). In both simple and complex arithmetic, young and older adults obtained poorer arithmetic performance under distraction relative to no-distraction conditions...

Emotional intelligence includes an assortment of factors related to emotion function. Such factors involve emotion recognition (in this case via facial expression), emotion trait, reactivity, and regulation. We aimed to investigate how the subjective appraisals of emotional intelligence (i.e. trait, reactivity, and regulation) are associated with objective emotion recognition accuracy, and how these associations differ between young and older adults. Data were extracted from the CamCAN dataset (189 adults: 57 young/118 older) from assessments measuring these emotion constructs...

BACKGROUND: The incidence of Alzheimer's disease (AD) in female gender compared with male has been addressed as a health concern, particularly in menopausal age. We here hypothesized that co-administration of NMDARs agonist (D-serine) and AMPARs endocytosis inhibitor (Tat-GluA23y) might be a potential target for alleviating memory impairment in sporadic Alzheimer model of rats. METHODS: Forty-eight female Wistar rats weighing 200-220 randomly divided into six groups...

BACKGROUND: Caress-like touch activates C-tactile (CT) afferents present in the skin of humans. It is generally assumed that this type of touch provides beneficial effects throughout the lifespan. However, little is known about its processing in later adulthood. Moreover, emotional responses to interpersonal vs. self-touch have not been investigated in older adults. METHOD: A total of 132 females from two age groups (older: 60-96 years; younger: 18-30) participated in a well-validated method of tactile stimulation, in which CT-optimal vs...

OBJECTIVE: The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model. METHODS: Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology. RESULTS: On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant...

Descriptive research on work ability is well advanced. However, literature is still far from explaining its consequences. Besides, Turkish literature has been quite limited in terms of considering the work ability concept. In the research, the work ability index, and task performance scale were adapted to Turkish. The research was patterned with quantitative method. According to findings, the improvement of work ability levels and increase in job satisfaction and task performance are related in the same direction...

Older adults tend to exhibit longer response times than younger adults in choice tasks across cognitive domains, such as perception, attention, and memory. The diffusion model has emerged as a standard model for analyzing age differences in choice behavior. Applications of the diffusion model to choice data from younger and older adults indicate that age-related slowing is driven by a more cautious response style and slower non-decisional processes, rather than by age differences in the rate of information accumulation...

Archival records of US Masters Swimming performances were examined for changes between 1981 and 2021. Both national records and top 10 swimmers were used. Substantial secular changes were found averaging 0.52%/yr, with women improving more than men and with improvements in national records greater than in the top 10. Performances by women in 2021 were at parity (national records) or near parity (top 10) with men in 1981. The results indicate that secular effects must be considered along with longitudinal age-related changes and cross-sectional cohort effects in interpreting age differences in physiological function...

We examined whether framing younger and older adults learning goals in terms of maximizing gains or minimizing losses impacts their ability to selectively remember high-value information. Specifically, we presented younger and older adults with lists of words paired with point values and participants were either told that they would receive the value associated with each word if they recalled it on a test or that they would lose the points associated with each word if they failed to recall it on the test. We also asked participants to predict the likelihood of recalling each word to determine if younger and older adults were metacognitively aware of any potential framing effects...

OBJECTIVES: In view of the fallout of the COVID-19 pandemic, psychologists face a challenge to document the pandemic-related change in emotional well-being of individuals and groups and evaluate the emotional response to this fallout over time. METHODSP: We contribute to this goal by analyzing the new CoSoWELL corpus (version 2.0), an 1.8 million-word collection of narratives written by over 1,300 older adults (55+ y.o.) in eight sessions before, during and after the global lockdown...

INTRODUCTION: The possible decline of cognitive functions with age has been in the focus of cognitive research in the last decades. The present study investigated effects of aging on conflict processing in a big dataset of a Stroop-inspired online training task. METHODS: We focused on the temporal dynamics of conflict processing in the light of task practice by means of inspecting delta plots and Lorenz-interference curves to gain insights on a process level. RESULTS: The results indicate a relatively constant increase of cognitive conflict over the course of adulthood and a decrease with practice...

OBJECTIVES: This study investigated whether race and sex moderated the relations of religious coping to telomere length (TL), a biomarker of cellular aging implicated in race-related health disparities. METHODS: Participant data were drawn from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study, which included 252 socioeconomically diverse African American and White men and women aged (30-64 years old). Cross-sectional multivariable regression analyses examined interactive associations of religious coping, race, and sex to TL, adjusting for other sociodemographic characteristics...

The present study was conducted to investigate the effects of Ocimum basilicum L. (OB) extract on learning and memory impairment in aged rats. Male rats were divided into the following experimental groups: Group 1 (control): including 2 months old rats, Group 2 (aged) including 2 years old rats, Groups 3-5 (aged-OB): including 2 years old rats received 50, 100, and 150 mg/kg OB for 8 weeks by oral gavage. Aging increased the delay to find the platform but, however, decreased the time spent in the target quadrant when tested by Morris water maze (MWM)...

RESEARCH QUESTION: Are semantic impairments in Alzheimer's disease (AD) partially due to deficits in spatial attention? METHODS AND RESULTS: In a target detection task, both older adults (OAs) and AD individuals were facilitated by valid spatial cues, but only OAs were impaired by invalid cues compared to neutral. In a reading task, spatial cues validly or invalidly cued the location of pictures, which were related or unrelated to subsequent, centrally presented, words...

BACKGROUND: Physical symptoms play an important role in late-life depression and may contribute to residual symptomatology after antidepressant treatment. In this exploratory study, we examined the role of specific bodily dimensions including movement, respiratory functions, fear of falling, cognition, and physical weakness in older people with depression. METHODS: Clinically stable older patients with major depression within a Psychiatric Consultation-Liaison program for Primary Care underwent comprehensive assessment of depressive symptoms, instrumental movement analysis, dyspnea, weakness, activity limitations, cognitive function, and fear of falling...

We investigated whether individuals who are good at recognizing previously presented items are also good at recognizing the context in which items were presented. We focused specifically on whether the relation between item recognition and context recognition abilities differs in younger and older adults. It has been hypothesized that context memory declines more rapidly in older adults due to an age-related deficit in associative binding or recollection. To test this hypothesis, younger and older adults were asked to remember lists of names and objects, as well as the context (i...