journal
https://read.qxmd.com/read/38634145/not-all-central-nervous-system-lymphomas-are-created-equal
#1
JOURNAL ARTICLE
Alvaro J Alencar, Juan Pablo Alderuccio
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634143/hypomethylating-agents-are-associated-with-high-rates-of-hematologic-toxicity-in-patients-with-secondary-myeloid-neoplasms-developing-after-acquired-aplastic-anemia
#2
JOURNAL ARTICLE
Matthew P Connor, Neeharika Prathapa, Noelle V Frey, Saar I Gill, Elizabeth O Hexner, Ximena Jordan Bruno, Catherine E Lai, Alison W Loren, Selina M Luger, Andrew H Matthews, Shannon R McCurdy, Alexander E Perl, David L Porter, Arlene Zeringue, Joseph H Oved, Timothy S Olson, Keith W Pratz, Daria V Babushok
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634141/outcome-of-infants-with-acute-lymphoblastic-leukemia-treated-with-the-chinese-children-s-cancer-group-acute-lymphoblastic-leukemia-2015-study-protocol
#3
JOURNAL ARTICLE
Alex Wk Leung, Jiaoyang Cai, Zhi Wan, Jiefen Qin, Yongjun Fang, Lirong Sun, Jiashi Zhu, Shaoyan Hu, Ningling Wang, Pan Gao, Xin Tian, Xiaofan Zhu, Fen Zhou, Xuedong Wu, Xiuli Ju, Xiaowen Zhai, Hua Jiang, Qun Hu, Changda Liang, Liangchun Yang, Hui Zhang, Jingyan Tang, Ju Gao, Ching-Hon Pui, Chi-Kong Li
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634128/-one-way-or-another-i-m-gonna-find-ya-mir-221-3p-finds-its-targets-via-small-extracellular-vesicles
#4
JOURNAL ARTICLE
Jonathan Tak-Sum Chow, Leonardo Salmena
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634127/beyond-adenosine-triphosphate-unveiling-the-pleiotropic-effects-of-pyruvate-kinase-activation-in-sickle-cell-anemia
#5
JOURNAL ARTICLE
https://read.qxmd.com/read/38634126/validation-of-mutated-cebpa-bzip-as-a-distinct-prognosis-entity-in-acute-myeloid-leukemia-a-study-by-the-spanish-pethema-registry
#6
JOURNAL ARTICLE
Esther Prados De la Torre, Josefina Serrano, David Martínez-Cuadrón, Laura Torres, Claudia Sargas, Rosa Ayala, Cristina Bilbao-Sieyro, María Carmen Chillón, María José Larráyoz, Elena Soria, Clara Aparicio-Pérez, Juan M Bergua, Teresa Bernal, Cristina Gil, Mar Tormo, Lorenzo Algarra, Juan M Alonso-Domínguez, Eduardo Rodriguez-Arbolí, Pilar Martínez-Sanchez, Ana Oliva, Ana M Colorado-Araujo, Carlos Rodríguez-Medina, Susana Vives, Lourdes Hermosín, Joaquín Martínez-López, Ramón García-Sanz, José A Pérez-Simón, María José Calasanz, María Teresa Gómez-Casares, Eva Barragán, Joaquín Sánchez-García J, Pau Montesinos
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634121/-irf4-bloc1s5-the-first-rearrangement-gene-identified-in-tempi-syndrome
#7
JOURNAL ARTICLE
Ming Zhao, Jia Liu, Qing Yu, Wenbin Xu, Zilu Zhang, Ze Fu, Mingyuan Jia, Xinyi Zeng, Chengyu Wu, Chenjing Ye, Chao Wu, Yingli Wu, Ruibao Ren, Junmin Li, Kankan Wang, Hua Yan
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634119/-tp3-binding-domain-mutations-are-bad-news-in-burkitt-lymphoma
#8
JOURNAL ARTICLE
Mitchell S Cairo
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38618686/unfriendly-protein-of-gata1-and-mechanisms-of-bone-marrow-failure
#9
JOURNAL ARTICLE
Yigal Dror
Not available.
April 11, 2024: Haematologica
https://read.qxmd.com/read/38618684/stem-cell-factor-and-erythropoietin-independent-production-of-cultured-reticulocytes
#10
JOURNAL ARTICLE
Emmanuel Olivier, Shouping Zhang, Zi Yan, Eric E Bouhassira
Cultured reticulocytes can supplement transfusion needs and offer promise for drug delivery and immune tolerization. They can be produced from induced pluripotent stem cells (iPSCs), but the 45-day culture time and cytokine costs make large-scale production prohibitive. To overcome these limitations, we have generated IPSCs that express constitutive SCF receptor and jak2 adaptor alleles. We show that iPSC lines carrying these alleles can differentiate into self-renewing erythroblast (SRE) that can proliferate for up to 70 cell-doubling in a cost-effective, chemically-defined, albumin- and cytokine-free medium...
April 11, 2024: Haematologica
https://read.qxmd.com/read/38618681/expedited-evaluation-of-hereditary-hematopoietic-malignancies-in-the-setting-of-stem-cell-transplantation
#11
JOURNAL ARTICLE
Gregory W Roloff, Satyajit Kosuri, Mariam T Nawas, Adam S DuVall, Anand A Patel, Peter A Riedell, Olatoyosi Odenike, Wendy Stock, Richard A Larson, Michael R Bishop, Emma Nunley, Lucy A Godley, Feighanne Hathaway, Daniela Del Gaudio, Soma Das, Lorraine E Canham, Michael W Drazer
Not available.
April 11, 2024: Haematologica
https://read.qxmd.com/read/38618679/molecular-responses-in-decitabine-and-decitabine-venetoclax-treated-patients-with-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#12
JOURNAL ARTICLE
Agata Gruszczynska, Abhishek Maiti, Christopher A Miller, Sai Mukund Ramakrishnan, Daniel C Link, Geoffrey L Uy, Allegra A Petti, Kala Hayes, Courtney D DiNardo, Farhad Ravandi, Timothy J Ley, David H Spencer, Feng Gao, Marina Y Konopleva, John S Welch
Not available.
April 11, 2024: Haematologica
https://read.qxmd.com/read/38618667/-sh2b3-alterations-in-a-novel-genetic-condition-juvenile-myelomonocytic-leukemia-and-myeloproliferative-neoplasia
#13
JOURNAL ARTICLE
Charlotte M Niemeyer, Miriam Erlacher
Not available.
April 11, 2024: Haematologica
https://read.qxmd.com/read/38618666/oral-iron-supplementation-new-formulations-old-questions
#14
JOURNAL ARTICLE
Kostas Pantopoulos
Iron deficiency anemia and pre-anemic iron deficiency are the most frequent pathologies. The first line of treatment involves oral iron supplementation. The simplest, least expensive, and most frequently prescribed drug is ferrous sulfate, while other ferrous salts and ferric complexes with polysaccharides or succinylated milk proteins are also widely used. In recent years, novel iron formulations have been developed, such as the lipophilic iron donor ferric maltol, or nanoparticle encapsulated sucrosomial® iron...
April 11, 2024: Haematologica
https://read.qxmd.com/read/38572568/soluble-b-cell-maturation-antigen-in-lacrimal-fluid-as-a-potential-biomarker-and-mediator-of-keratopathy-in-multiple-myeloma
#15
JOURNAL ARTICLE
Umair Munawar, Johanna Theuersbacher, Maximilian J Steinhardt, Xiang Zhou, Seungbin Han, Silvia Nerreter, Cornelia Vogt, Shilpa Kurian, Thorsten Keller, Ann-Katrin Regensburger, Eva Teufel, Julia Mersi, Max Bittrich, Franziska Seifert, Malik S Haider, Leo Rasche, Jost Hillenkamp, Hermann Einsele, Daniel Kampik, K Martin Kortüm, Johannes M Waldschmidt
Belantamab mafodotin (belantamab) is a first-in-class anti-BCMA antibody-drug conjugate approved for the treatment of triple-class refractory multiple myeloma. It provides a unique therapeutic option for patients ineligible for CAR-T and bispecific antibody therapy, and/or patients progressing on anti-CD38 treatment where CAR-T and bispecifics might be kept in reserve. Wider use of the drug can be challenged by its distinct ocular side effect profile, including corneal microcysts and keratopathy. While dose reduction has been the most effective way to reduce these toxicities, the underlying mechanism of this BCMA off-target effect remains to be characterized...
April 4, 2024: Haematologica
https://read.qxmd.com/read/38572567/outcomes-after-chimeric-antigen-receptor-t-cell-therapy-across-large-b-cell-lymphoma-subtypes
#16
JOURNAL ARTICLE
Christianne Bourlon, Claire Roddie, Tobias Menne, Jane Norman, Maeve O'Reilly, Adam Gibb, Caroline Besley, Sridhar Chaganti, Carlos Gonzalez Arias, Ceri Jones, Abdalla Dikair, Sharon Allen, Frances Seymour, Wendy Osborne, Amrith Mathew, William Townsend, Piers Em Patten, Eleni Thoulouli, Ahmed Abdulgawad, Sanne Lugthart, Robin Sanderson, Amy A Kirkwood, Andrea Kuhnl
Not available.
April 4, 2024: Haematologica
https://read.qxmd.com/read/38572564/-hes6-knockdown-in-human-hematopoietic-precursor-cells-reduces-their-in-vivo-engraftment-potential-and-their-capacity-to-differentiate-into-erythroid-cells-b-cells-t-cells-and-plasmacytoid-dendritic-cells
#17
JOURNAL ARTICLE
Tamara De Vos, Nicole Oatman, Lena Boehme, Tom Putteman, Imke Velghe, Yana Van Droogenbroeck, Stijn De Munter, Michaela Cesnekova, Filip Van Nieuwerburgh, Bart Vandekerckhove, Jan Philippe, Tom Taghon
Hematopoiesis is driven by molecular mechanisms that induce differentiation and proliferation of hematopoietic stem cells and their progeny. This involves the activity of various transcription factors, such as members of the Hairy/Enhancer of Split (HES) family, and important roles for both HES1 and HES4 have been shown in normal and malignant hematopoiesis. Here, we investigated the role of HES6 in human hematopoiesis using in vitro and in vivo models. Using bulk and scRNA-seq data, we show that HES6 is expressed during erythroid/megakaryocyte and pDC development, as well as in multipotent precursors and at specific stages of T- and B-cell development following preBCR and preTCR signalling, respectively...
April 4, 2024: Haematologica
https://read.qxmd.com/read/38572562/a-phase-i-study-of-pevonedistat-azacitidine-and-venetoclax-in-patients-with-relapsed-refractory-acute-myeloid-leukemia
#18
JOURNAL ARTICLE
Guru Subramanian Guru Murthy, Antoine N Saliba, Aniko Szabo, Alexandra Harrington, Sameem Abedin, Karen Carlson, Laura Michaelis, Lyndsey Runaas, Arielle Baim, Alex Hinman, Sonia Maldonado-Schmidt, Annapoorna Venkatachalam, Karen S Flatten, Kevin L Peterson, Paula A Schneider, Mark Litzow, Scott H Kaufmann, Ehab Atallah
Azacitidine/venetoclax is an active regimen in patients with newly diagnosed AML. However, primary or secondary resistance to azacitidine/venetoclax is an area of unmet need and overexpression of MCL-1 is suggested to be a potential resistance mechanism. Pevonedistat inhibits MCL-1 through activation of NOXA, and pevonedistat/azacitidine has previously shown activity in AML. To assess the tolerability and efficacy of adding pevonedistat to azacitidine/venetoclax in relapsed/refractory AML, we conducted a phase I multicenter openlabel study in 16 adults with relapsed/refractory AML...
April 4, 2024: Haematologica
https://read.qxmd.com/read/38572560/universal-germline-genetic-testing-in-patients-with-hematologic-malignancies-using-dna-isolated-from-nail-clippings
#19
JOURNAL ARTICLE
Ozge Ceyhan-Birsoy, Elise Fiala, Satshil Rana, Margaret Sheehan, Jennifer Kennedy, Zarina Yelskaya, Vikas Rai, Yirong Li, Ciyu Yang, Donna Wong, Ivelise Rijo, Jacklyn Casanova, Joshua Somar, Nikita Mehta, Hyeonjin Park, Silvana Ostafi, Kanika Arora, Angelika Padunan, Mark D Ewalt, Umut Aypar, Panieh Terraf, Maksym Misyura, Sofia Haque, Gerald G Behr, Tamanna Haque, Maria Sulis, Mark B Geyer, Christopher Forlenza, Meghan C Thompson, Maria Carlo, Alicia Latham, Ying Liu, Ahmet Zehir, Rose Brannon, Michael Berger, Luis A Diaz, Ahmet Dogan, Marc Ladanyi, Kseniya Petrova-Drus, Khedoudja Nafa, Kenneth Offit, Maria Arcila, Zsofia K Stadler, Michael F Walsh, Diana Mandelker
Not available.
April 4, 2024: Haematologica
https://read.qxmd.com/read/38572559/mutual-regulation-of-cd4-t-cells-and-intravascular-fibrin-in-infections
#20
JOURNAL ARTICLE
Tonina T Mueller, Mona Pilartz, Manovriti Thakur, Torben LangHeinrich, Junfu Luo, Rebecca Block, Jonathan K L Hoeflinger, Sarah Meister, Flavio Karaj, Laura Garcia Perez, Rupert Öllinger, Thomas Engleitner, Jakob Thoss, Michael Voelkl, Claudia Tersteeg, Uwe Koedel, Alexander Zigman Kohlmaier, Daniel Teupser, Malgorzata Wygrecka, Haifeng Ye, Klaus T Preissner, Helena Radbruch, Sefer Elezkurtaj, Matthias Mack, Philipp Von Hundelshausen, Christian Weber, Steffen Massberg, Christian Schulz, Roland Rad, Samuel Huber, Hellen Ishikawa-Ankerhold, Bernd Engelmann
Innate myeloid cells especially neutrophils and their extracellular traps are known to promote intravascular coagulation and thrombosis formation in infections and various other conditions. Innate myeloid cell dependent fibrin formation can support systemic immunity while its dysregulation enhances the severity of infectious diseases. Less is known about the immune mechanisms preventing dysregulation of fibrin homeostasis in infection. During experimental systemic infections local fibrin deposits in the liver microcirculation cause rapid arrest of CD4+ T cells...
April 4, 2024: Haematologica
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