journal
https://read.qxmd.com/read/38695142/nivolumab-combined-with-brentuximab-vedotin-with-or-without-mediastinal-radiotherapy-for-relapsed-refractory-primary-mediastinal-large-b-cell-lymphoma
#21
JOURNAL ARTICLE
Loic Renaud, Juliette Wencel, Arnaud Pagès, Ahmad Al Jijakli, Hannah Moatti, Laurent Quero, Vincent Camus, Pauline Brice
Not available.
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695140/are-we-ready-for-new-strategies-to-prevent-stroke-in-children-with-sickle-cell-disease
#22
JOURNAL ARTICLE
Giovanna Russo, Raffaella Colombatti
Not available.
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695139/minimal-residual-disease-monitoring-in-childhood-philadelphia-positive-acute-lymphoblastic-leukemia-prognostic-significance-and-correlation-between-multiparameter-flow-cytometry-and-real-time-quantitative-polymerase-chain-reaction
#23
JOURNAL ARTICLE
Jun Li, Anni Lu, Yangyang Gao, Yang Wan, Junxia Wang, Jingliao Zhang, Tianyuan Hu, Peng Wu, Xiaojuan Chen, Yao Zou, Yumei Chen, Li Zhang, Ye Guo, Wenyu Yang, Chengwen Li, Yingchi Zhang, Xiaofan Zhu
Not available.
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695137/cd22-targeted-glyco-engineered-natural-killer-cells-offer-a-further-treatment-option-for-b-cell-acute-lymphoblastic-leukemia
#24
JOURNAL ARTICLE
Xin Jin, Rui Sun, Zhu Li, Xianwu Wang, Xia Xiong, Wenyi Lu, Hairong Lyu, Xia Xiao, Yunpeng Tian, Hongkai Zhang, Zhihong Fang, Luqiao Wang, Mingfeng Zhao
Not available.
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695132/soluble-urokinase-plasminogen-activator-receptor-is-associated-with-kidney-disease-and-its-progression-in-sickle-cell-anemia
#25
JOURNAL ARTICLE
Rima S Zahr, Sara R Rashkin, Maria Armila Ruiz, Laila Elsherif, Guohui Ren, Guadalupe Salas, Kenneth I Ataga, Victor R Gordeuk, Jeffrey Lebensburger, Xu Zhang, Santosh L Saraf
Not available.
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695130/two-sample-mendelian-randomization-analysis-reveals-causal-relationships-between-blood-lipids-and-venous-thromboembolism
#26
JOURNAL ARTICLE
Wei Huang, Yan Zou, Kun Zhang, Shi Yao, Shi-Hao Tang, Hao Wu, Peng-Fei Wang, Han-Zhong Xue, Tie-Lin Yang, Kun Zhang, Yan Guo
Venous Thromboembolism (VTE) is a complex disease that can be classified into two subtypes: Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). Previous observational studies have shown associations between lipids and VTE, but causality remains unclear. Hence, by utilizing 241 lipid-related traits as exposures and data from the FinnGen consortium on VTE, DVT, and PE as outcomes, we conducted two-sample Mendelian randomization (MR) analysis to investigate causal relationships between lipids and VTE, DVT and PE...
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695126/the-initial-molecular-response-predicts-the-deep-molecular-response-but-not-treatment-free-remission-maintenance-in-a-real-world-chronic-myeloid-leukemia-cohort
#27
JOURNAL ARTICLE
Sandrine Saugues, Céline Lambert, Elisabeth Daguenet, Gabrielle Roth-Guepin, Françoise Huguet, Pascale Cony-Makhoul, Hyacinthe Johnson Ansah, Martine Escoffre-Barbe, Ali Turhan, Philippe Rousselot, Andreï Tchirkov, Dalil Hamroun, Eric Hermet, Bruno Pereira, Marc G Berger
In chronic myeloid leukemia, the identification of early molecular predictors of stable treatment-free remission (TFR) after tyrosine kinase inhibitor (TKI) discontinuation is challenging. The predictive values of residual disease (BCR::ABL1 quantification) at months 3 and 6 and more recently, BCR::ABL1 transcript halving time (HT) have been described, but no study compared the predictive value of different early parameters. Using a real-world cohort of 408 patients, we compared the performance of the ELTS score, BCR::ABL1 HT, and residual disease at month 3 and 6 to predict the molecular response, achievement of the TKI discontinuation criteria, and TFR maintenance...
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695123/treatment-of-chronic-phase-chronic-myeloid-leukemia-in-patients-randomized-to-dasatinib-or-imatinib-after-suboptimal-responses-to-three-months-of-imatinib-therapy-final-5-year-results-from-dascern
#28
JOURNAL ARTICLE
Jorge E Cortes, Qian Jiang, Jianxiang Wang, Jianyu Weng, Huanling Zhu, Xiaoli Liu, Andreas Hochhaus, Dong-Wook Kim, Jerald Radich, Michael Savona, Patricia Martin-Regueira, Oumar Sy, Giuseppe Saglio
Early molecular response (EMR) at 3 months is predictive of improved overall survival (OS) and progression-free survival (PFS) in patients with chronic myeloid leukemia in the chronic phase (CML-CP). Although about one-third of patients treated with first-line imatinib do not achieve EMR, long-term OS and PFS are still observed in most patients. DASCERN (NCT01593254) is a prospective, phase IIb, randomized trial evaluating a switch to dasatinib in patients who have not achieved EMR after 3 months of treatment with first-line imatinib...
May 2, 2024: Haematologica
https://read.qxmd.com/read/38695122/red-cell-mass-measurement-is-still-useful-for-myeloproliferative-neoplasms-management-comment-to-role-of-red-cell-mass-evaluation-in-myeloproliferative-neoplasms-with-splanchnic-vein-thrombosis-and-normal-hemoglobin-value-a-study-of-the-france-intergroupe-des
#29
JOURNAL ARTICLE
https://read.qxmd.com/read/38654683/do-it-once-but-do-it-right
#30
JOURNAL ARTICLE
Layal Yasin, Arndt Borkhardt
Not available.
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654668/monocyte-response-to-sars-cov-2-protein-orf8-is-associated-with-severe-covid-19-infection-in-patients-with-chronic-lymphocytic-leukemia
#31
JOURNAL ARTICLE
Gordon J Ruan, Xiaosheng Wu, Kimberly A Gwin, Michelle K Manske, Jithma P Abeykoon, Vaishali Bhardwaj, Taylor L Witter, Matthew J Schellenberg, Kari G Rabe, Neil E Kay, Sameer A Parikh, Thomas E Witzig
The open reading frame 8 (ORF8) protein, encoded by the SARS-CoV-2 virus after infection, stimulates monocytes/macrophages to produce pro-inflammatory cytokines. We hypothesized that a positive ex vivo monocyte response to ORF8 protein pre-COVID-19 would be associated with subsequent severe COVID-19. We tested ORF8 ex vivo on peripheral blood mononuclear cells (PBMCs) from 26 anonymous healthy blood donors and measured intracellular cytokine/chemokine levels in monocytes by flow cytometry. The % monocytes staining positive in the sample and change in mean fluorescence intensity (ΔMFI) after ORF8 were used to calculate the adjusted MFI for each cytokine...
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654666/differential-activation-of-basal-and-il-7-induced-pi3k-akt-mtor-and-jak-stat5-signaling-distinguishes-pediatric-from-adult-acute-lymphoblastic-leukemia
#32
JOURNAL ARTICLE
Marta B Fernandes, A Margarida Gomes, Mariana L Oliveira, Joana Caldas, Paulo Lúcio, Rathana Kim, Aurélie Caye-Eude, Filomena Pereira, Aida B De Sousa, Alessia De Stefano, Matilde Y Follo, Maria V Soares, João F Lacerda, Joana Desterro, Hélène Cavé, Emmanuelle Clappier, Ximo Duarte, Patrícia Ribeiro, João T Barata
Not available.
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654662/central-nervous-system-prophylaxis-it-s-time-to-start-from-scratch
#33
JOURNAL ARTICLE
Diego Villa
Not available.
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654660/time-from-diagnosis-to-treatment-has-no-impact-on-survival-in-newly-diagnosed-acute-myeloid-leukemia-treated-with-venetoclax-based-regimens
#34
JOURNAL ARTICLE
David Baden, Sven Zukunft, Gema Hernandez, Nadine Wolgast, Sophie Steinhauser, Alexander Pohlmann, Christoph Schliemann, Jan-Henrik Mikesch, Bjorn Steffen, Tim Sauer, Maher Hanoun, Kerstin Schafer-Eckart, Stefan W Krause, Mathias Hanel, Hermann Einsele, Edgar Jost, Tim H Brummendorf, Sebastian Scholl, Andreas Hochhaus, Andreas Neubauer, Andreas Burchert, Martin Kaufmann, Dirk Niemann, Markus Schaich, Wolfgang Blau, Alexander Kiani, Martin Gorner, Ulrich Kaiser, Johannes Kullmer, Thomas Weber, Wolfgang E Berdel, Gerhard Ehninger, Carsten Muller-Tidow, Uwe Platzbecker, Hubert Serve, Martin Bornhauser, Christoph Rollig, Claudia D Baldus, Lars Fransecky
In newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed acute myeloid leukemia undergoing venetoclax-based therapy in two distinct cohorts. By querying the Study Alliance Leukemia database and the global health network TriNetX, we identified 138 and 717 patients respectively with an average age of 76 and 72 years who received venetoclax-based firstline therapy...
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654659/follicular-lymphoma-treatment-decisions-put-gelf-on-the-shelf
#35
JOURNAL ARTICLE
Brian K Link
Not available.
April 24, 2024: Haematologica
https://read.qxmd.com/read/38654656/evaluation-of-the-atm-l2307f-germline-variant-in-121-italian-pedigrees-with-familial-myeloproliferative-neoplasms
#36
JOURNAL ARTICLE
Oscar Borsani, Roland Jäger, Daniela Pietra, Ines Flieder, Giacomo Riccaboni, Robert Kralovics, Elisa Rumi
Not available.
April 24, 2024: Haematologica
https://read.qxmd.com/read/38634145/not-all-central-nervous-system-lymphomas-are-created-equal
#37
JOURNAL ARTICLE
Alvaro J Alencar, Juan Pablo Alderuccio
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634143/hypomethylating-agents-are-associated-with-high-rates-of-hematologic-toxicity-in-patients-with-secondary-myeloid-neoplasms-developing-after-acquired-aplastic-anemia
#38
JOURNAL ARTICLE
Matthew P Connor, Neeharika Prathapa, Noelle V Frey, Saar I Gill, Elizabeth O Hexner, Ximena Jordan Bruno, Catherine E Lai, Alison W Loren, Selina M Luger, Andrew H Matthews, Shannon R McCurdy, Alexander E Perl, David L Porter, Arlene Zeringue, Joseph H Oved, Timothy S Olson, Keith W Pratz, Daria V Babushok
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634141/outcome-of-infants-with-acute-lymphoblastic-leukemia-treated-with-the-chinese-children-s-cancer-group-acute-lymphoblastic-leukemia-2015-study-protocol
#39
JOURNAL ARTICLE
Alex Wk Leung, Jiaoyang Cai, Zhi Wan, Jiefen Qin, Yongjun Fang, Lirong Sun, Jiashi Zhu, Shaoyan Hu, Ningling Wang, Pan Gao, Xin Tian, Xiaofan Zhu, Fen Zhou, Xuedong Wu, Xiuli Ju, Xiaowen Zhai, Hua Jiang, Qun Hu, Changda Liang, Liangchun Yang, Hui Zhang, Jingyan Tang, Ju Gao, Ching-Hon Pui, Chi-Kong Li
Not available.
April 18, 2024: Haematologica
https://read.qxmd.com/read/38634128/-one-way-or-another-i-m-gonna-find-ya-mir-221-3p-finds-its-targets-via-small-extracellular-vesicles
#40
JOURNAL ARTICLE
Jonathan Tak-Sum Chow, Leonardo Salmena
Not available.
April 18, 2024: Haematologica
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