Andreas Berge, Johannes Lundin, Anna Bläckberg, Torgny Sunnerhagen, Magnus Rasmussen
PURPOSE: Patients with non-beta-hemolytic streptococcal bacteremia (NBHSB) are at risk of infective endocarditis (IE). Patients with cardiac implantable electronic device (CIED) have been described to have an increased risk of IE. The aim of the study was to describe a population-based cohort of patients with NBHSB and CIED and variables associated with IE and recurrent NBHSB. METHODS: All episodes with NBHSB in blood culture from 2015 to 2018 in a population of 1...
April 18, 2024: Infection
Sarina K Butzer, Kirstin Faust, André Oberthuer, Charlotte Kleindiek, Benjamin Kuehne, Christoph Haertel, Katrin Mehler
PURPOSE: Very low birth weight (VLBW) infants are at a risk of spontaneous focal intestinal perforation (FIP). Treatment includes supportive care, antibiotics, and drainage with/without surgery. Broad-spectrum antibiotic agents like carbapenems are applied frequently, although their use is not well-supported by the limited evidence of causal pathogens. We hypothesize that the use of carbapenems may not be necessary in VLBW infants with FIP. Our primary objective was to evaluate the antimicrobial use in VLBW infants with FIP in a cohort of the German Neonatal Network (GNN)...
April 18, 2024: Infection
Vladimir L Cousin, Leonce Mwizerwa, Raphael Joye, Noémie Wagner, Tomasz Nalecz, Maya Bouhabib, Tornike Sologashvili, Julie Wacker, Jacques Schrenzel, Maurice Beghetti, Angelo Polito
PURPOSE: Children with congenital heart disease (CHD) from low- to middle-income countries (LMIC) are suspected to have a high prevalence of antibiotic-resistant microorganisms (ARMOs) carriage, but data are currently lacking. Carriage of ARMOs could impact the post-operative course in pediatric intensive care unit (PICU). The aim of the study was to assess the prevalence of ARMOs carriage in children with CHD from LMIC and its impact on post-operative outcomes. METHODS: This was a retrospective monocentric study from 01/2019 to 12/2022...
April 18, 2024: Infection
Tjeerd Pieter van Staa, Alexander Pate, Glen P Martin, Anita Sharma, Paul Dark, Tim Felton, Xiaomin Zhong, Sian Bladon, Neil Cunningham, Ellie L Gilham, Colin S Brown, Mariyam Mirfenderesky, Victoria Palin, Diane Ashiru-Oredope
PURPOSE: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. The purpose of the study was to measure the associations of specific exposures (deprivation, ethnicity, and clinical characteristics) with incident sepsis and case fatality. METHODS: Two research databases in England were used including anonymized patient-level records from primary care linked to hospital admission, death certificate, and small-area deprivation...
April 16, 2024: Infection
Luling Wu, Xuemin Fu, Benno Pütz, Renfang Zhang, Li Liu, Wei Song, Ling Weng, Yueming Shao, Zhihang Zheng, Jingna Xun, Ximei Han, Ting Wang, Yinzhong Shen, Hongzhou Lu, Bertram Müller-Myhsok, Jun Chen
BACKGROUND: The global mortality rate resulting from HIV-associated cryptococcal disease is remarkably elevated, particularly in severe cases with dissemination to the lungs and central nervous system (CNS). Regrettably, there is a dearth of predictive analysis regarding long-term survival, and few studies have conducted longitudinal follow-up assessments for comparing anti-HIV and antifungal treatments. METHODS: A cohort of 83 patients with HIV-related disseminated cryptococcosis involving the lung and CNS was studied for 3 years to examine survival...
April 13, 2024: Infection
Lisanne Boekhoud, Helena M E A Schaap, Rick L Huizinga, Tycho J Olgers, Jan C Ter Maaten, Douwe F Postma, Hjalmar R Bouma
PURPOSE: Sepsis has a high incidence and a poor prognosis. Early recognition is important to facilitate timely initiation of adequate care. Sepsis screening tools, such as the (quick) Sequential Organ Failure Assessment ((q)SOFA) and National Early Warning Score (NEWS), could help recognize sepsis. These tools have been validated in a general immunocompetent population, while their performance in immunocompromised patients, who are particularly at risk of sepsis development, remains unknown...
April 12, 2024: Infection
Markus Bauswein, Ehab Eid, Lisa Eidenschink, Barbara Schmidt, André Gessner, Dennis Tappe, Dániel Cadar, Merle M Böhmer, Laura Jockel, Nora van Wickeren, Tamara Garibashvili, Isabel Wiesinger, Christina Wendl, Josef G Heckmann, Klemens Angstwurm, Martin Freyer
BACKGROUND: Within endemic regions in southern and eastern Germany, Borna disease virus 1 (BoDV-1) causes rare zoonotic spill-over infections in humans, leading to encephalitis with a high case-fatality risk. So far, intra-vitam diagnosis has mainly been based on RT-qPCR from cerebrospinal fluid (CSF) and serology, both being associated with diagnostic challenges. Whilst low RNA copy numbers in CSF limit the sensitivity of RT-qPCR from this material, seroconversion often occurs late during the course of the disease...
April 12, 2024: Infection
Myriam Drysdale, Mehmet Berktas, Daniel C Gibbons, Catherine Rolland, Louis Lavoie, Emily J Lloyd
PURPOSE: To evaluate clinical outcomes associated with sotrovimab use during Omicron BA.2 and BA.5 predominance. METHODS: Electronic databases were searched for observational studies published in peer-reviewed journals, preprint articles and conference abstracts from January 1, 2022 to February 27, 2023. RESULTS: The 14 studies identified were heterogeneous in terms of study design, population, endpoints and definitions. They included > 1...
April 11, 2024: Infection
Alireza Sadeghi, Fatemeh Nouri, Ehsan Taherifard, Mohammad Amin Shahlaee, Niloofar Dehdari Ebrahimi
PURPOSE: The prevalence of obesity is an escalating concern in modern populations, predominantly attributed to the widespread adoption of sedentary lifestyles observed globally. Extensive research has established a significant association between obesity and Helicobacter pylori (H. pylori). Nonetheless, a comprehensive assessment of the global prevalence of H. pylori among individuals with obesity remains undetermined. METHODS: A systematic search strategy was applied to PubMed, Scopus, and Web of Science...
April 10, 2024: Infection
Michaela Rippl, Anton Burkhard-Meier, Ulf Schönermarck, Michael Fischereder
PURPOSE: Diarrhea is an important cause of morbidity and mortality in immunocompromised patients. After including sapovirus to the viral gastroenteritis screening of our institution's laboratory, we noticed an increase in sapovirus infections among kidney transplant recipients. Therefore, we assumed former gastrointestinal tract infections with unidentified pathogens could have been caused by sapovirus. To better understand the characteristics of a sapovirus infection in a high-risk group we initiated this study...
April 9, 2024: Infection
Vincent Johann Heck, Tobias Prasse, Kristina Klug, Juan Manuel Vinas-Rios, Stavros Oikonomidis, Alexander Klug, Nikolaus Kernich, Maximilian Weber, Nicolas von der Höh, Maximilian Lenz, Sebastian Gottfried Walter, Bastian Himpe, Peer Eysel, Max Joseph Scheyerer
PURPOSE: Since an increase in the occurrence of native vertebral osteomyelitis (VO) is expected and reliable projections are missing, it is urgent to provide a reliable forecast model and make it a part of future health care considerations. METHODS: Comprehensive nationwide data provided by the Federal Statistical Office of Germany were used to forecast total numbers and incidence rates (IR) of VO as a function of age and gender until 2040. Projections were done using autoregressive integrated moving average model on historical data from 2005 to 2019 in relation to official population projections from 2020 to 2040...
April 9, 2024: Infection
Salvatore Rotundo, Maria Teresa Tassone, Francesca Serapide, Alessandro Russo, Enrico Maria Trecarichi
In the context of the evolving global health landscape shaped by the COVID-19 pandemic, tuberculosis (TB) is gaining renewed attention as a reemerging threat even in low-endemic countries. Immunological tests such as the tuberculin skin test (TST) and interferon-gamma release assay (IGRA) are pivotal in identifying tuberculosis infection (TBI). However, their inability to distinguish between past and ongoing infection poses a diagnostic challenge, possibly leading to the unnecessary treatment of a significant portion of the population with potential side effects...
April 8, 2024: Infection
Anne-Eva Post, Erik Bathoorn, Douwe F Postma, Dirk-Jan Slebos, Onno W Akkerman
PURPOSE: Bronchoalveolar lavage is commonly used in clinical practice for unresolved pneumonia. However, bronchoalveolar lavage is not suitable for all patients as it is an invasive procedure and can worsen oxygenation. The diagnostic value of bronchial wash and sputum has been debated extensively over the years. In this study, we aim to compare the diagnostic value in several pathogens of bronchoalveolar lavage and bronchial wash, and secondarily bronchoalveolar lavage and sputum. METHODS: We retrospectively included all adult patients in our hospital who underwent bronchoalveolar lavage, bronchial wash, and where sputum sampling was done between January 1st of 2018 and December 31st of 2021...
April 8, 2024: Infection
Katharina S Appel, Carolin Nürnberger, Thomas Bahmer, Christian Förster, Maria Cristina Polidori, Mirjam Kohls, Tanja Kraus, Nora Hettich-Damm, Julia Petersen, Sabine Blaschke, Isabel Bröhl, Jana Butzmann, Hiwa Dashti, Jürgen Deckert, Michael Dreher, Karin Fiedler, Carsten Finke, Ramsia Geisler, Frank Hanses, Sina M Hopff, Björn-Erik O Jensen, Margarethe Konik, Kristin Lehnert, Susana M Nunes de Miranda, Lazar Mitrov, Olga Miljukov, Jens-Peter Reese, Gernot Rohde, Margarete Scherer, Kristin Tausche, Johannes J Tebbe, Jörg Janne Vehreschild, Florian Voit, Patricia Wagner, Martin Weigl, Christina Lemhöfer
PURPOSE: The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. The aim of the study was to verify the functionality and correlates of a recently developed PCS score. METHODS: The PCS score was applied to the prospective, multi-center cross-sectoral cohort (in- and outpatients with SARS-CoV-2 infection) of the "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment and patient-reported outcome measure questionnaires were analyzed at 3 and 12 months (3/12MFU) after diagnosis...
April 8, 2024: Infection
Carole Eldin, Elif Nurtop, Benjamin Coiffard, Nathalie Colombini, Laetitia Ninove, Stéphane Priet, Karine Barthélémy, Martine Reynaud-Gaubert, Xavier de Lamballerie
No abstract text is available yet for this article.
April 7, 2024: Infection
Miguel Mansilla-Polo, Daniel Martín-Torregrosa, Sara Becerril-Andrés, Rafael Botella-Estrada
No abstract text is available yet for this article.
April 7, 2024: Infection
Bram Spruijtenburg, Bruna Jacomel Favoreto de Souza Lima, Sonia T Granadillo Tosar, Andrew M Borman, Cecilie Torp Andersen, Summiya Nizamuddin, Suhail Ahmad, João Nobrega de Almeida Junior, Vânia Aparecida Vicente, Joshua D Nosanchuk, Jochem B Buil, Sybren de Hoog, Eelco F J Meijer, Jacques F Meis, Theun de Groot
PURPOSE: Rare yeasts species are increasingly reported as causative agents of invasive human infection. Proper identification and antifungal therapy are essential to manage these infections. Candida blankii is one of these emerging pathogens and is known for its reduced susceptibility to multiple antifungals. METHODS: To obtain more insight into the characteristics of this species, 26 isolates reported as C. blankii were investigated using genetic and phenotypical approaches...
April 4, 2024: Infection
Xiaoqian Wang, Wenying Wang, Jingjing Li, Ruifang An, Lihong Chen, Jiajing Lin, Dabao Xu, Jin Qiu, Weihua Song, Mijiti Patiman, Hongjie Ruan, Gang Wang, Fengxia Xue, Xu Wang, Xiaowan Luo, Qi Ruan, Ling Shi, Chun Zhang, Lina Hu, Shijin Wang, Hong Shi, Xiaoli Wang, Songling Zhang, Yingxiong Li, Jing Lu, Baojin Wang, Hongyan Xu, Hong Ye, Bei Zhang, Chunlian Zhang, Sumin Qian, Qiong Wu, Wen Jia, Chuan Li, Qinping Liao
PURPOSE: To evaluate the efficacy and safety of oral ibrexafungerp (HS-10366) versus placebo in Chinese patients with vulvovaginal candidiasis (VVC). METHODS: A double-blind, placebo-controlled, randomized, multicenter phase III study was conducted in symptomatic VVC patients. Patients received (2:1) twice-daily oral ibrexafungerp 300 mg or matching placebo for 1 day. The primary endpoint was clinical cure (vulvovaginal signs and symptoms [VSS] score = 0) at test-of-cure (TOC) on day 11 ± 3...
April 3, 2024: Infection
Sara Giordana Rimoldi, Riccardo Nodari, Alberto Rizzo, Alessandro Tamoni, Concetta Longobardi, Cristina Pagani, Silvia Grosso, Federica Salari, Laura Galimberti, Pietro Olivieri, Giuliano Rizzardini, Emanuele Catena, Spinello Antinori, Francesco Comandatore, Antonio Castelli, Maria Rita Gismondo
PURPOSE: Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance. CASE PRESENTATION: On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C...
April 1, 2024: Infection
Dima Hattab, Mumen F A Amer, Zina M Al-Alami, Athirah Bakhtiar
The COVID-19 pandemic has affected hundreds of millions of individuals and caused more than six million deaths. The prolonged pandemic duration and the continual inter-individual transmissibility have contributed to the emergence of a wide variety of SARS-CoV-2 variants. Genomic surveillance and phylogenetic studies have shown that substantial mutations in crucial supersites of spike glycoprotein modulate the binding affinity of the evolved SARS-COV-2 lineages to ACE2 receptors and modify the binding of spike protein with neutralizing antibodies...
March 30, 2024: Infection
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.