Nina Vibeche Skei, Tom Ivar Lund Nilsen, Randi Marie Mohus, Hallie C Prescott, Stian Lydersen, Erik Solligård, Jan Kristian Damås, Lise Tuset Gustad
No abstract text is available yet for this article.
September 21, 2023: Infection
Andrés Grau-Echevarría, Carolina Labrandero-Hoyos, Rodrigo Peñuelas-Leal, Amparo Pérez-Ferriols
No abstract text is available yet for this article.
September 19, 2023: Infection
Patrick Zuercher, André Moser, Luis Garcia de Guadiana-Romualdo, Martin J Llewelyn, Rolf Graf, Theresia Reding, Philippe Eggimann, Yok-Ai Que, Josef Prazak
BACKGROUND: Several studies suggested pancreatic stone protein (PSP) as a promising biomarker to predict mortality among patients with severe infection. The objective of the study was to evaluate the performance of PSP in predicting intensive care unit (ICU) mortality and infection severity among critically ill adults admitted to the hospital for infection. METHODS: A systematic search across Cochrane Central Register of Controlled Trials and MEDLINE databases (1966 to February 2022) for studies on PSP published in English using 'pancreatic stone protein', 'PSP', 'regenerative protein', 'lithostatin' combined with 'infection' and 'sepsis' found 46 records...
September 14, 2023: Infection
Pierantonio Grimaldi, Antonio Russo, Mariantonietta Pisaturo, Paolo Maggi, Enrico Allegorico, Ivan Gentile, Vincenzo Sangiovanni, Annamaria Rossomando, Rossella Pacilio, Giosuele Calabria, Raffaella Pisapia, Canio Carriero, Alfonso Masullo, Elio Manzillo, Grazia Russo, Roberto Parrella, Giuseppina Dell'Aquila, Michele Gambardella, Antonio Ponticiello, Lorenzo Onorato, Nicola Coppola
INTRODUCTION: The aim of this study was to investigate how long hospitalized patients stayed positive to the nasopharyngeal swab, and what demographic and clinical factors influence the time-to-negative swab. METHODS: We enrolled in a multicenter, observational, retrospective study involving 17 COVID-19 units in eight cities of the Campania, southern Italy all patients hospitalized from March 2020 to May 2021 diagnosed with Severe Acute Respiratory Distress Syndrome-Coronavirus-2 (SARS-CoV-2) infection for whom time-to-negative swab was available...
September 13, 2023: Infection
Racha Amarthya Sree, Anand Gupta, Nitin Gupta, Sadhana Veturi, L Siva Kumar Reddy, Masrath Begum, Etrouth Shravani, HariPriya Reddy Challa, Satti Santhosh Reddy, Adarsh Singamsetty, Murthy Arumilli, P Naveen Reddy, Praveen Kumar Tirlangi
INTRODUCTION: Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections commonly cause hospital-acquired infections. The study aimed to compare the outcomes of CRKP infections between patients receiving ceftazidime avibactam +/- aztreonam and polymyxins in a hospital setting with a high prevalence of New Delhi Metallo Beta Lactamase production. METHODS: We conducted a retrospective cohort study from January 2020 to September 2022 in critically ill adult patients admitted to a non-COVID-19 medical intensive care unit with CRKP infection...
September 11, 2023: Infection
Daniel Schwarzkopf, Norman Rose, Carolin Fleischmann-Struzek, Beate Boden, Heike Dorow, Andreas Edel, Marcus Friedrich, Falk A Gonnert, Jürgen Götz, Matthias Gründling, Markus Heim, Kirill Holbeck, Ulrich Jaschinski, Christian Koch, Christian Künzer, Khanh Le Ngoc, Simone Lindau, Ngoc B Mehlmann, Jan Meschede, Patrick Meybohm, Dominique Ouart, Christian Putensen, Michael Sander, Jens-Christian Schewe, Peter Schlattmann, Götz Schmidt, Gerhard Schneider, Claudia Spies, Ferdinand Steinsberger, Kai Zacharowski, Sebastian Zinn, Konrad Reinhart
PURPOSE: Timely and accurate data on the epidemiology of sepsis are essential to inform policy decisions and research priorities. We aimed to investigate the validity of inpatient administrative health data (IAHD) for surveillance and quality assurance of sepsis care. METHODS: We conducted a retrospective validation study in a disproportional stratified random sample of 10,334 inpatient cases of age ≥ 15 years treated in 2015-2017 in ten German hospitals...
September 9, 2023: Infection
Antonio Vena, Matteo Bassetti, Laura Mezzogori, Francesco Marchesi, Martin Hoenigl, Daniele Roberto Giacobbe, Silvia Corcione, Michele Bartoletti, Jannik Stemler, Livio Pagano, Oliver A Cornely, Jon Salmanton-García
BACKGROUND: We assessed the laboratory diagnosis and treatment of invasive fungal disease (IFD) in Italy to detect limitations and potential for improvement. METHODS: The survey was available online at management capacity/, and collected variables such as (a) institution profile, (b) perceptions of IFD in the respective institution, (c) microscopy, (d) culture and fungal identification, (e) serology, (f) antigen detection, (g) molecular tests, (h) susceptibility testing and (i) therapeutic drug monitoring (TDM)...
September 1, 2023: Infection
Susanne Dyckhoff-Shen, Jan P Bewersdorf, Nina C Teske, Stefanie Völk, Hans-Walter Pfister, Uwe Koedel, Matthias Klein
PURPOSE: There is an overlap in the cerebrospinal fluid (CSF) characteristics of patients presenting with different etiologies of CSF pleocytosis. Here, we characterized patients with CSF pleocytosis treated in a large hospital. METHODS: A retrospective cohort study of 1150 patients with an elevated CSF leukocyte count > 5 cells/µl treated at a university hospital in Germany from January 2015 to December 2017 was performed. Information on clinical presentation, laboratory parameters, diagnosis and outcome was collected...
September 1, 2023: Infection
Johannes Camp, Marianne Bayrhuber, Natascha Anka, Valerie Heine, Manuela Glattacker, Erik Farin-Glattacker, Siegbert Rieg
PURPOSE: To determine whether a novel intervention improves the adherence to guideline-based preventive measures in asplenic patients at risk of post-splenectomy sepsis (PSS). METHODS: We used a prospective controlled, two-armed historical control group design to compare a novel, health action process approach (HAPA)-based telephonic intervention involving both patients and their general practitioners to usual care. Eligible patients were identified in cooperation with the insurance provider AOK Baden-Wuerttemberg, Germany...
September 1, 2023: Infection
Wen-Yong Zhou, Lei Shen, Jian-Xin Shi, Xing-Hui Gao, Jun Yang, Shi-Jie Fu, Xu-Feng Pan, Min-Fang Zhu, Shen Zhang, Chong Zhang, Feng Li, Hai Zhang, Feng Yao, Fred C Tenover, Yi-Wei Tang, Wen-Tao Fang
PURPOSE: Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits of using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet the needs of quick CRO determination for donor lungs before acquisition. In this study, we explored a novel screening method by using Xpert® Carba-R assay for CRO in donor lungs in a real-time manner to reduce CRO-associated DDI mortality...
August 31, 2023: Infection
Nicole Maison, Jimmy Omony, Sophia Rinderknecht, Laura Kolberg, Melanie Meyer-Bühn, Erika von Mutius, Johannes Hübner, Ulrich von Both
INTRODUCTION: Following lockdown periods and restricting public health measures in response to the COVID-19 pandemic, respiratory tract infections (RTIs) rose significantly worldwide. This led to an increased burden on children's hospitals compromising medical care of acutely and chronically ill children. We characterized changes in the epidemiological pattern of circulating respiratory viral infections. METHODS: We assessed the number of patients with RTIs and the annual distribution of virus detections between 2019 and 2022 based on 4809 clinical samples (4131 patients) from a German pediatric tertiary care-center...
August 29, 2023: Infection
Albane Roseau-Vincenti, Emmanuel Forestier, Jean-Philippe Lanoix, Cécile Ricard, Marie-Christine Carret, Pauline Caraux-Paz, Marc Paccalin, Gaëtan Gavazzi, Claire Roubaud-Baudron
PURPOSE: Enterobacteriaceae (EB) bloodstream infections (BSI) are frequent and serious in older patients. Physicians are faced with the dilemma of prescribing early appropriate empirical antibiotics to limit the risk of death, and sparing broad-spectrum antibiotic prescription. The aim of the study was to assess the rate of appropriate empirical antibiotics prescription to treat EB BSI in older patients and its impact on survival. METHODS: This study conducted in 49 centres enrolled retrospectively up to the 10 last consecutive patients aged 75 years and over and treated for EB BSI...
August 22, 2023: Infection
Daniel Hornuss, Philipp Mathé, Susanne Usadel, Stefan Zimmermann, Matthias Müller, Siegbert Rieg
PURPOSE: Recent studies point toward a potential benefit of doxycycline use for post-exposure prophylaxis (PEP) or pre-exposure prophylaxis (PrEP) to prevent sexually transmitted infections (STIs). Although prescribing doxycycline in a prophylactic intention is not generally recommended yet, we noticed an increasing number of inquiries from individuals within the LGBTQ community for doxycycline prescriptions. METHODS: We conducted an anonymous online survey to evaluate the current extent of doxycycline use for PEP or PrEP within the LGBTQ community using REDCap electronic data capture tools...
August 22, 2023: Infection
Elisabeth Neser, Philipp Jung, Alexander Halfmann, Matthias Schröder, Lorenz Thurner, Sören L Becker, Sophie Schneitler
PURPOSE: Blood culture (BC) diagnostics are influenced by many factors. We performed a targeted interdisciplinary analysis to analyse effects of various measures on BC diagnostics performance. METHODS: A diagnostic stewardship initiative was conducted at two intervention and two control wards in a German tertiary level hospital. The initiative comprised staff training on the correct indications and sampling for BC, implementation of information cards, labels to identify the collection site, regular BC bottle feedback including the number of bottles, filling volumes and identified pathogens; and the use of a specific sampling device (BD Vacutainer® )...
August 17, 2023: Infection
Kirstine K Søgaard, Vladimira Hinic, Daniel Goldenberger, Alexander Gensch, Michael Schweitzer, Veronika Bättig, Martin Siegemund, Stefano Bassetti, Roland Bingisser, Michael Tamm, Manuel Battegay, Maja Weisser, Daiana Stolz, Nina Khanna, Adrian Egli
PURPOSE: Panel PCR tests provide rapid pathogen identification. However, their diagnostic performance is unclear. We assessed the performance of the Biofire© FilmArray pneumonia (PN)-panel against standard culture in broncho-alveolar lavage (BAL) samples. METHODS: Setting: University Hospital Basel (February 2019 to July 2020), including hospitalized patients with a BAL (± pneumonia). We determined sensitivity and specificity of the PN-panel against standard culture...
August 12, 2023: Infection
Nina Vibeche Skei, Tom Ivar Lund Nilsen, Randi Marie Mohus, Hallie C Prescott, Stian Lydersen, Erik Solligård, Jan Kristian Damås, Lise Tuset Gustad
BACKGROUND: Few studies have reported on mortality beyond one year after sepsis. We aim to describe trends in short- and long-term mortality among patients admitted with sepsis, and to describe the association between clinical characteristics and mortality for improved monitoring, treatment and prognosis. METHODS: Patients ≥ 18 years admitted to all Norwegian hospitals (2008-2021) with a first sepsis episode were identified using Norwegian Patient Registry and International Classification of Diseases 10th Revision codes...
August 12, 2023: Infection
Anna Barbiero, Tommaso Manciulli, Michele Spinicci, Iacopo Vellere, Maria Grazia Colao, Gian Maria Rossolini, Alessandro Bartoloni, Didier Raoult, Lorenzo Zammarchi
INTRODUCTION: The Scalp Eschar and Neck Lymph Adenopathy After a Tick Bite (SENLAT) syndrome is frequently caused by Rickettsia slovaca and Rickettsia raoultii. Only six microbiologically confirmed SENLAT cases have been reported in Italy between 1996 and 2021. We report ten cases of SENLAT seen between 2015 and 2022 in a tertiary care center in Tuscany, Italy. CASES PRESENTATION: All patients were women; most common symptoms were scalp eschar on the site of tick bite (100%) and cervical lymphadenopathy (90%)...
August 11, 2023: Infection
Yannis R Hübner, Nikolai Spuck, Moritz Berger, Stefan Schlabe, Gereon J Rieke, Sven Breitschwerdt, Kathrin van Bremen, Christian P Strassburg, Maria A Gonzalez-Carmona, Jan-Christian Wasmuth, Jürgen K Rockstroh, Christoph Boesecke, Malte B Monin
No abstract text is available yet for this article.
August 9, 2023: Infection
Berit Lange, Veronika K Jaeger, Manuela Harries, Viktoria Rücker, Hendrik Streeck, Sabine Blaschke, Astrid Petersmann, Nicole Toepfner, Matthias Nauck, Max J Hassenstein, Maren Dreier, Isabell von Holt, Axel Budde, Antonia Bartz, Julia Ortmann, Marc-André Kurosinski, Reinhard Berner, Max Borsche, Gunnar Brandhorst, Melanie Brinkmann, Kathrin Budde, Marek Deckena, Geraldine Engels, Marc Fenzlaff, Christoph Härtel, Olga Hovardovska, Alexander Katalinic, Katja Kehl, Mirjam Kohls, Stefan Krüger, Wolfgang Lieb, Kristin M Meyer-Schlinkmann, Tobias Pischon, Daniel Rosenkranz, Nicole Rübsamen, Jan Rupp, Christian Schäfer, Mario Schattschneider, Anne Schlegtendal, Simon Schlinkert, Lena Schmidbauer, Kai Schulze-Wundling, Stefan Störk, Carsten Tiemann, Henry Völzke, Theresa Winter, Christine Klein, Johannes Liese, Folke Brinkmann, Patrick F Ottensmeyer, Jens-Peter Reese, Peter Heuschmann, André Karch
PURPOSE: Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected population-based data allowing for the assessment of the protection level in real time. METHODS: In the IMMUNEBRIDGE project, we harmonised data and biosamples for nine population-/hospital-based studies (total number of participants n = 33,637) to provide estimates for protection levels against SARS-CoV-2 infection and severe COVID-19 between June and November 2022...
August 2, 2023: Infection
Stefanie Sammet, Veronique Touzeau-Römer, Eva Wolf, Pia Schenk-Westkamp, Birgit Romano, Elke Gersbacher, Ulrich Kastenbauer, Christoph Boesecke, Jürgen Rockstroh, Stefan Scholten, Stephan Schneeweiss, Julia Roider, Ulrich Seybold
BACKGROUND: Currently available antiretroviral 2-drug regimen (2DR) fixed dose combinations may not be suitable for specific situations including the presence of resistance associated mutations (RAM) or drug - drug interactions (DDI). The data on the use of the non-nucleoside reverse transcriptase inhibitor doravirine (DOR) and the integrase inhibitor dolutegravir (DTG) as an alternative 2DR remain scarce. METHODS: People living with HIV with DOR + DTG as a 2DR are being followed in a prospective observational study...
August 1, 2023: Infection
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