Anna Lena Jung, Malene Møller Jørgensen, Rikke Bæk, Marie Artho, Kathrin Griss, Maria Han, Wilhelm Bertrams, Timm Greulich, Rembert Koczulla, Stefan Hippenstiel, Dominik Heider, Norbert Suttorp, Bernd Schmeck
PURPOSE: Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites, mainly in tropical and subtropical countries. Plasmodium falciparum (P. falciparum) is the most prevalent cause on the African continent and responsible for most malaria-related deaths globally. Important medical needs are biomarkers for disease severity or disease outcome. A potential source of easily accessible biomarkers are blood-borne small extracellular vesicles (sEVs). METHODS: We performed an EV Array to find proteins on plasma sEVs that are differentially expressed in malaria patients...
March 24, 2023: Infection
D Stelzle, C Makasi, V Schmidt, C Trevisan, I Van Damme, C Ruether, P Dorny, P Magnussen, G Zulu, K E Mwape, E Bottieau, C Prazeres da Costa, U F Prodjinotho, H Carabin, E Jackson, A Fleury, S Gabriël, B J Ngowi, A S Winkler
PURPOSE: Neurocysticercosis is common in regions endemic for Taenia solium. Active-stage neurocysticercosis can be treated with antiparasitic medication, but so far no study on efficacy and safety has been conducted in Africa. METHODS: We conducted a prospective cohort study on treatment of neurocysticercosis in Tanzania between August 2018 and January 2022. Patients were initially treated with albendazole (15 mg/kg/d) for 10 days and followed up for 6 months...
March 24, 2023: Infection
Sandra Chamat-Hedemand, Anders Dahl, Lauge Østergaard, Magnus Arpi, Emil Fosbøl, Jonas Boel, Kamal Preet Kaur, Louise Bruun Oestergaard, Trine K Lauridsen, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun
PURPOSE: Streptococcal bloodstream infections (BSIs) are common, yet prognostic factors are poorly investigated. We aimed to investigate the mortality according to streptococcal species and seasonal variation. METHODS: Patients with streptococcal BSIs from 2008 to 2017 in the Capital Region of Denmark were investigated, and data were crosslinked with nationwide registers for the identification of comorbidities. A multivariable logistic regression analysis was performed to assess mortality according to streptococcal species and season of infection...
March 24, 2023: Infection
Kirsten Schmidt-Hellerau, Claudia Raichle, Maria M Ruethrich, Jörg J Vehreschild, Julia Lanznaster, Susana M Nunes de Miranda, Claudia Bausewein, Maria J G T Vehreschild, Carolin E M Koll, Steffen T Simon, Kerstin Hellwig, Björn-Erik O Jensen, Norma Jung
PURPOSE: Symptom control for patients who were severely ill or dying from COVID-19 was paramount while resources were strained and infection control measures were in place. We aimed to describe the characteristics of SARS-CoV-2 infected patients who received specialized palliative care (SPC) and the type of SPC provided in a larger cohort. METHODS: From the multi-centre cohort study Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS), data of patients hospitalized with SARS-CoV-2 infection documented between July 2020 and October 2021 were analysed...
March 23, 2023: Infection
Sridhar Mangalesh, Sharmila Dudani
No abstract text is available yet for this article.
March 17, 2023: Infection
Laven Mavarani, Sarah Albayrak-Rena, Anja Potthoff, Martin Hower, Sebastian Dolff, Stefanie Sammet, Felix Maischack, Dirk Schadendorf, Börge Schmidt, Stefan Esser
PURPOSE: Overweight and obesity have increased in people living with HIV (PLH). Our study evaluated weight, body-mass-index (BMI), and waist-to-hip ratio (WHR) change over 5 years of follow-up in PLH compared to the general population. METHODS: HIV-positive participants in the HIV Heart Aging (HIVH) study were matched 1:2 by age and sex with HIV-negative controls of the population-based Heinz Nixdorf Recall (HNR) study. Both studies were recruited in the German Ruhr area...
March 17, 2023: Infection
Jens Gottlieb, Susanne Simon, Jürgen Barton, Michaela Barnikel, Marcus Bachmann, Merle-Sophie Klingenberg, Tobias Veit, Nikolaus Kneidinger
PURPOSE: Lung transplant (LTx) recipients are at risk for poor outcomes from coronavirus disease 2019 (COVID-19). The aim of the study was to assess the outcome of patients receiving pre-exposure prophylaxis (PrEP) with tixagevimab and cilgavimab after LTx. METHODS: All LTx recipients with outpatient visits from February 28th to October 31st, 2022 at two German centers were included. Baseline characteristics were recorded and patients followed until November 30rd, 2022...
March 16, 2023: Infection
Anna Stoliaroff-Pepin, Caroline Peine, Tim Herath, Johannes Lachmann, Wiebke Hellenbrand, Delphine Perriat, Achim Dörre, Andreas Nitsche, Janine Michel, Marica Grossegesse, Natalie Hofmann, Thomas Rinner, Claudia Kohl, Annika Brinkmann, Tanja Meyer, Daniel Stern, Fridolin Treindl, Brigitte G Dorner, Sascha Hein, Laura Werel, Eberhard Hildt, Sven Gläser, Helmut Schühlen, Caroline Isner, Alexander Peric, Ammar Ghouzi, Annette Reichardt, Matthias Janneck, Guntram Lock, Dominik Huster, Thomas Grünewald, Lars Schaade, Ole Wichmann, Thomas Harder
PURPOSE: COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave. METHODS: We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates...
March 13, 2023: Infection
Amit Dey, K Vaishak, Dikshita Deka, Arun Kumar Radhakrishnan, Sujay Paul, Priyadarshini Shanmugam, Alice Peace Daniel, Surajit Pathak, Asim K Duttaroy, Antara Banerjee
PURPOSE: The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on COVID-19 infections from an epigenetic scenario and develop future perspectives of epi-drugs to treat the disease. METHODS: Original research articles and review studies related to COVID-19 were searched and analyzed from the Google Scholar/PubMed/Medline databases mainly between 2019 and 2022 to brief the recent work...
March 12, 2023: Infection
Fabienne B Fischer, Melina Bigler, Daniel Mäusezahl, Jan Hattendorf, Adrian Egli, Timothy R Julian, Franziska Rölli, Valeria Gaia, Monica Wymann, Françoise Fridez, Stefanie Bertschi
Switzerland has one of the highest annual Legionnaires' disease (LD) notification rates in Europe (7.8 cases/100,000 population in 2021). The main sources of infection and the cause for this high rate remain largely unknown. This hampers the implementation of targeted Legionella spp. control efforts. The SwissLEGIO national case-control and molecular source attribution study investigates risk factors and infection sources for community-acquired LD in Switzerland. Over the duration of one year, the study is recruiting 205 newly diagnosed LD patients through a network of 20 university and cantonal hospitals...
March 11, 2023: Infection
Marianne Ask Torvik, Stig Haugset Nymo, Ståle Haugset Nymo, Lars Petter Bjørnsen, Hanne Winge Kvarenes, Eirik Hugaas Ofstad
OBJECTIVE: To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population. METHODS: Retrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018-2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly sepsis-related, or not sepsis-related. RESULTS: Of 633 hospital deaths, 179 (28%) were sepsis-related, and 136 (21%) were possibly sepsis-related...
March 9, 2023: Infection
Kevin B Laupland, Felicity Edwards, Patrick N A Harris, David L Paterson
PURPOSE: Although Klebsiella aerogenes (formerly Enterobacter aerogenes) and Enterobacter cloacae share many phenotypic characteristics, controversy exists as to whether they cause clinically distinguishable infections. The objective of this study was to determine the comparative incidence, determinants, and outcomes of K. aerogenes and E. cloacae bloodstream infections (BSI). METHODS: Population-based surveillance was conducted among residents aged ≥ 15 years of Queensland, Australia during 2000-2019...
March 7, 2023: Infection
Stefano Tancredi, Arnaud Chiolero, Cornelia Wagner, Moa Lina Haller, Patricia Chocano-Bedoya, Natalia Ortega, Nicolas Rodondi, Laurent Kaufmann, Elsa Lorthe, Hélène Baysson, Silvia Stringhini, Gisela Michel, Chantal Lüdi, Erika Harju, Irene Frank, Medea Imboden, Melissa Witzig, Dirk Keidel, Nicole Probst-Hensch, Rebecca Amati, Emiliano Albanese, Laurie Corna, Luca Crivelli, Julia Vincentini, Semira Gonseth Nusslé, Murielle Bochud, Valérie D'Acremont, Philipp Kohler, Christian R Kahlert, Alexia Cusini, Anja Frei, Milo A Puhan, Marco Geigges, Marco Kaufmann, Jan Fehr, Stéphane Cullati
PURPOSE: We aimed to assess the seroprevalence trends of SARS-CoV-2 antibodies in several Swiss cantons between May 2020 and September 2021 and investigate risk factors for seropositivity and their changes over time. METHODS: We conducted repeated population-based serological studies in different Swiss regions using a common methodology. We defined three study periods: May-October 2020 (period 1, prior to vaccination), November 2020-mid-May 2021 (period 2, first months of the vaccination campaign), and mid-May-September 2021 (period 3, a large share of the population vaccinated)...
March 4, 2023: Infection
Zhangkai J Cheng, Jing Shan
No abstract text is available yet for this article.
March 3, 2023: Infection
Francesco Vladimiro Segala, Pia Clara Pafundi, Carlotta Masciocchi, Barbara Fiori, Eleonora Taddei, Laura Antenucci, Giulia De Angelis, Silvia Guerriero, Roberta Pastorino, Andrea Damiani, Brunella Posteraro, Maurizio Sanguinetti, Gennaro De Pascale, Massimo Fantoni, Rita Murri
PURPOSE: SARS-COV-2 pandemic led to antibiotic overprescription and unprecedented stress on healthcare systems worldwide. Knowing the comparative incident risk of bloodstream infection due to multidrug-resistant pathogens in COVID ordinary wards and intensive care-units may give insights into the impact of COVID-19 on antimicrobial resistance. METHODS: Single-center observational data extracted from a computerized dataset were used to identify all patients who underwent blood cultures from January 1, 2018 to May 15, 2021...
March 3, 2023: Infection
Valentina Cirello, Marina Lugaresi, Alessandro Manzo, Eva Balla, Gerardina Fratianni, Francesca Solari, Luca Persani, Laura Fugazzola, Irene Campi
PURPOSE: The clinical outcome of COVID-19 disease is worse in males, and the reasons of this gender disparity are currently unclear, though evidences point to a combination of biological and gender-specific factors. A phenomenon unique to the female gender is the fetal cell microchimerism (FCM), defined as the presence of fetal microchimeric cells in maternal organs and in the circulation for years after delivery and usually evaluated by assessing the presence of male cells or DNA in a woman...
March 1, 2023: Infection
Timo Mayerhöfer, Sebastian Klein, Bernhard Wernly, Hans Flaatten, Bertrand Guidet, Dylan W De Lange, Jesper Fjølner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Antonio Artigas, Peter Vernon van Heerden, Bernardo Bollen Pinto, Joerg C Schefold, Rui Moreno, Maurizio Cecconi, Wojciech Szczeklik, Christian Jung, Michael Joannidis
BACKGROUND: Several studies have found an association between diabetes mellitus, disease severity and outcome in COVID-19 patients. Old critically ill patients are particularly at risk. This study aimed to investigate the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. METHODS: This multicentre international prospective cohort study was performed in 151 ICUs across 26 countries. We included patients ≥ 70 years of age with a confirmed SARS-CoV-2 infection admitted to the intensive care unit from 19th March 2020 through 15th July 2021...
March 1, 2023: Infection
Sofie Schumacher, Jon Salmanton-García, Andrea Liekweg, Muriel Rolfes, Danila Seidel, Sibylle C Mellinghoff, Oliver A Cornely
PURPOSE: Influenza infections have substantial impact on healthcare institutions. While vaccination is the most effective preventive measure against influenza infection, vaccination coverage in healthcare workers is low. The study investigates the impact of an intensified influenza vaccination campaign in a maximum-care hospital on influenza vaccination coverage in healthcare workers during the COVID-19 pandemic in 2020/21. METHODS: Building on findings from our previously published review Schumacher et al...
February 28, 2023: Infection
Monique Boukobza, Emila Ilic-Habensus, Bruno Mourvillier, Xavier Duval, Jean-Pierre Laissy
BACKGROUND: Brain abscesses (BA) are severe lesions in the course of infective endocarditis (IE). We compare the bacteriological, clinical data, background, associated lesions, and outcome of IE patients with and without BAs, and assess the MRI characteristics of BAs. METHODS: Retrospective study of 351 consecutive patients with definite IE (2005-2020) and at least one brain MRI. Patients with and without BAs were compared. RESULTS: Twenty patients (5...
February 28, 2023: Infection
Norma Jung, Lukas Tometten, Rika Draenert
PURPOSE: Antimicrobial resistance poses a major threat to human health globally and antibiotic overuse is a main driver of resistance. Antimicrobial stewardship (AMS) was developed to improve the rationale use of antibiotics. The Choosing Wisely campaign was initiated to ameliorate medical practice through avoidance of unnecessary diagnostic and therapeutic procedures. Our objective was to give an overview on the Choosing Wisely recommendations related to AMS practices from a selection of different countries in order to define future needs...
February 25, 2023: Infection
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