Renate Ziegler, Hendrik Arnold, Ralph Bertram, Walter Geißdörfer, Matthias Pauschinger, Theodor Fischlein, Francesco Pollari, Joerg Steinmann
PURPOSE: The spectrum of causative organisms in infective endocarditis (IE) has changed significantly in the last decades. Reliable pathogen detection is crucial for appropriate antimicrobial therapy for IE. The aim of the study was to evaluate the diagnostic value of microbiological methods for detecting the causative microorganism of IE and to analyze the spectrum of pathogens. METHODS: A total of 224 cases (211 unique patients, some with multiple surgeries) were included into this retrospective study...
April 7, 2023: Infection
Mariantonietta Pisaturo, Loredana Alessio, Alessandra Di Fraia, Margherita Macera, Carmine Minichini, Emanuele Cordua, Lorenzo Onorato, Gaetano Scotto, Giovanni Di Caprio, Federica Calò, Caterina Sagnelli, Nicola Coppola
No abstract text is available yet for this article.
April 6, 2023: Infection
Paola Bertuccio, Melania Degli Antoni, Davide Minisci, Silvia Amadasi, Francesco Castelli, Anna Odone, Eugenia Quiros-Roldan
PURPOSE: Oral antivirals (nirmatrelvir/ritonavir and molnupiravir), intravenous short treatment of remdesivir and anti-SARS-CoV-2 monoclonal antibodies (mAbs) have been used for early COVID-19 treatments in high risk of disease progression patients. The term long COVID has been used to refer to a range of new, returning, or ongoing symptoms after SARS-CoV-2 infection. Little is known about the impact of such therapies on long COVID. METHODS: This is a retrospective observational study, including all outpatients evaluated from April 2021 to March 2022 in Brescia, Lombardy, northern Italy...
April 6, 2023: Infection
Teresa M Nygren, Antonia Pilic, Merle M Böhmer, Christiane Wagner-Wiening, Ole Wichmann, Wiebke Hellenbrand
PURPOSE: Despite being vaccine-preventable, tick-borne encephalitis (TBE) continues to cause considerable morbidity in Germany. Limited insight into potentially debilitating consequences of TBE may partially underly low (~ 20%) TBE vaccine uptake. We aimed to systematically assess TBE sequelae and other consequences. METHODS: Routinely notified TBE patients from 2018 to 2020 from Southern Germany were invited to telephone interviews acutely and again after 18 months...
April 6, 2023: Infection
Marcus Hentrich, Boris Böll, Daniel Teschner, Jens Panse, Timo Schmitt, Jan-Hendrik Naendrup, Martin Schmidt-Hieber, Julia Neitz, Eva Fiegle, Enrico Schalk
PURPOSE: Overall, insertion of central venous catheter (CVC) into femoral veins (FV) has been shown to be associated with a higher risk of infection compared with subclavian and internal jugular (IJV/SCV) CVC, but no data are available on the impact of the FV insertion site on the CVC-related bloodstream infections (CRBSI) risk in patients with cancer. The objective of the study is to compare CRBSI rates and incidences of FV with those of internal jugular and subclavian vein (IJV/SCV CVC) as observed in the prospective SECRECY registry...
April 4, 2023: Infection
Ulrich von Both, Dieter Adam, Johannes Hübner
Theodor Escherich (1857-1911) was one of the key players in early paediatric infectious diseases (PID). In fact, he can be regarded as the first paediatric infectious diseases physician and the founder of this subspecialty. During his long years in service for children, he spent 6 years at the Dr von Hauner children's hospital (1884-1890), laying the foundations for PID clinical care and research in Munich. Walter Marget, founder of this journal and co-founder of the German Society for Infectious Diseases (DGI) graduated from medical school in 1946 and practised in Munich since 1967...
April 4, 2023: Infection
Mathias W Pletz, Andrea Steiner, Miriam Kesselmeier, Bettina Löffler, Jens Maschmann, Andreas Stallmach, Sabine Trommer
No abstract text is available yet for this article.
April 3, 2023: Infection
Dorra Guermazi, Panos Arvanitis, Dimitrios Farmakiotis
No abstract text is available yet for this article.
April 1, 2023: Infection
Anna Lena Jung, Malene Møller Jørgensen, Rikke Bæk, Marie Artho, Kathrin Griss, Maria Han, Wilhelm Bertrams, Timm Greulich, Rembert Koczulla, Stefan Hippenstiel, Dominik Heider, Norbert Suttorp, Bernd Schmeck
PURPOSE: Malaria is a life-threatening mosquito-borne disease caused by Plasmodium parasites, mainly in tropical and subtropical countries. Plasmodium falciparum (P. falciparum) is the most prevalent cause on the African continent and responsible for most malaria-related deaths globally. Important medical needs are biomarkers for disease severity or disease outcome. A potential source of easily accessible biomarkers are blood-borne small extracellular vesicles (sEVs). METHODS: We performed an EV Array to find proteins on plasma sEVs that are differentially expressed in malaria patients...
March 24, 2023: Infection
D Stelzle, C Makasi, V Schmidt, C Trevisan, I Van Damme, C Ruether, P Dorny, P Magnussen, G Zulu, K E Mwape, E Bottieau, C Prazeres da Costa, U F Prodjinotho, H Carabin, E Jackson, A Fleury, S Gabriël, B J Ngowi, A S Winkler
PURPOSE: Neurocysticercosis is common in regions endemic for Taenia solium. Active-stage neurocysticercosis can be treated with antiparasitic medication, but so far no study on efficacy and safety has been conducted in Africa. METHODS: We conducted a prospective cohort study on treatment of neurocysticercosis in Tanzania between August 2018 and January 2022. Patients were initially treated with albendazole (15 mg/kg/d) for 10 days and followed up for 6 months...
March 24, 2023: Infection
Sandra Chamat-Hedemand, Anders Dahl, Lauge Østergaard, Magnus Arpi, Emil Fosbøl, Jonas Boel, Kamal Preet Kaur, Louise Bruun Oestergaard, Trine K Lauridsen, Gunnar Gislason, Christian Torp-Pedersen, Niels Eske Bruun
PURPOSE: Streptococcal bloodstream infections (BSIs) are common, yet prognostic factors are poorly investigated. We aimed to investigate the mortality according to streptococcal species and seasonal variation. METHODS: Patients with streptococcal BSIs from 2008 to 2017 in the Capital Region of Denmark were investigated, and data were crosslinked with nationwide registers for the identification of comorbidities. A multivariable logistic regression analysis was performed to assess mortality according to streptococcal species and season of infection...
March 24, 2023: Infection
Kirsten Schmidt-Hellerau, Claudia Raichle, Maria M Ruethrich, Jörg J Vehreschild, Julia Lanznaster, Susana M Nunes de Miranda, Claudia Bausewein, Maria J G T Vehreschild, Carolin E M Koll, Steffen T Simon, Kerstin Hellwig, Björn-Erik O Jensen, Norma Jung
PURPOSE: Symptom control for patients who were severely ill or dying from COVID-19 was paramount while resources were strained and infection control measures were in place. We aimed to describe the characteristics of SARS-CoV-2 infected patients who received specialized palliative care (SPC) and the type of SPC provided in a larger cohort. METHODS: From the multi-centre cohort study Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS), data of patients hospitalized with SARS-CoV-2 infection documented between July 2020 and October 2021 were analysed...
March 23, 2023: Infection
Sridhar Mangalesh, Sharmila Dudani
No abstract text is available yet for this article.
March 17, 2023: Infection
Laven Mavarani, Sarah Albayrak-Rena, Anja Potthoff, Martin Hower, Sebastian Dolff, Stefanie Sammet, Felix Maischack, Dirk Schadendorf, Börge Schmidt, Stefan Esser
PURPOSE: Overweight and obesity have increased in people living with HIV (PLH). Our study evaluated weight, body-mass-index (BMI), and waist-to-hip ratio (WHR) change over 5 years of follow-up in PLH compared to the general population. METHODS: HIV-positive participants in the HIV Heart Aging (HIVH) study were matched 1:2 by age and sex with HIV-negative controls of the population-based Heinz Nixdorf Recall (HNR) study. Both studies were recruited in the German Ruhr area...
March 17, 2023: Infection
Jens Gottlieb, Susanne Simon, Jürgen Barton, Michaela Barnikel, Marcus Bachmann, Merle-Sophie Klingenberg, Tobias Veit, Nikolaus Kneidinger
PURPOSE: Lung transplant (LTx) recipients are at risk for poor outcomes from coronavirus disease 2019 (COVID-19). The aim of the study was to assess the outcome of patients receiving pre-exposure prophylaxis (PrEP) with tixagevimab and cilgavimab after LTx. METHODS: All LTx recipients with outpatient visits from February 28th to October 31st, 2022 at two German centers were included. Baseline characteristics were recorded and patients followed until November 30rd, 2022...
March 16, 2023: Infection
Anna Stoliaroff-Pepin, Caroline Peine, Tim Herath, Johannes Lachmann, Wiebke Hellenbrand, Delphine Perriat, Achim Dörre, Andreas Nitsche, Janine Michel, Marica Grossegesse, Natalie Hofmann, Thomas Rinner, Claudia Kohl, Annika Brinkmann, Tanja Meyer, Daniel Stern, Fridolin Treindl, Brigitte G Dorner, Sascha Hein, Laura Werel, Eberhard Hildt, Sven Gläser, Helmut Schühlen, Caroline Isner, Alexander Peric, Ammar Ghouzi, Annette Reichardt, Matthias Janneck, Guntram Lock, Dominik Huster, Thomas Grünewald, Lars Schaade, Ole Wichmann, Thomas Harder
PURPOSE: COViK, a prospective hospital-based multicenter case-control study in Germany, aims to assess the effectiveness of COVID-19 vaccines against severe disease. Here, we report vaccine effectiveness (VE) against COVID-19-caused hospitalization and intensive care treatment during the Omicron wave. METHODS: We analyzed data from 276 cases with COVID-19 and 494 control patients recruited in 13 hospitals from 1 December 2021 to 5 September 2022. We calculated crude and confounder-adjusted VE estimates...
March 13, 2023: Infection
Amit Dey, K Vaishak, Dikshita Deka, Arun Kumar Radhakrishnan, Sujay Paul, Priyadarshini Shanmugam, Alice Peace Daniel, Surajit Pathak, Asim K Duttaroy, Antara Banerjee
PURPOSE: The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put the world in a medical crisis for the past three years; nearly 6.3 million lives have been diminished due to the virus outbreak. This review aims to update the recent findings on COVID-19 infections from an epigenetic scenario and develop future perspectives of epi-drugs to treat the disease. METHODS: Original research articles and review studies related to COVID-19 were searched and analyzed from the Google Scholar/PubMed/Medline databases mainly between 2019 and 2022 to brief the recent work...
March 12, 2023: Infection
Fabienne B Fischer, Melina Bigler, Daniel Mäusezahl, Jan Hattendorf, Adrian Egli, Timothy R Julian, Franziska Rölli, Valeria Gaia, Monica Wymann, Françoise Fridez, Stefanie Bertschi
Switzerland has one of the highest annual Legionnaires' disease (LD) notification rates in Europe (7.8 cases/100,000 population in 2021). The main sources of infection and the cause for this high rate remain largely unknown. This hampers the implementation of targeted Legionella spp. control efforts. The SwissLEGIO national case-control and molecular source attribution study investigates risk factors and infection sources for community-acquired LD in Switzerland. Over the duration of one year, the study is recruiting 205 newly diagnosed LD patients through a network of 20 university and cantonal hospitals...
March 11, 2023: Infection
Marianne Ask Torvik, Stig Haugset Nymo, Ståle Haugset Nymo, Lars Petter Bjørnsen, Hanne Winge Kvarenes, Eirik Hugaas Ofstad
OBJECTIVE: To examine the prevalence of advanced frailty, comorbidity, and age among sepsis-related deaths in an adult hospital population. METHODS: Retrospective chart reviews of deceased adults within a Norwegian hospital trust, with a diagnosis of infection, over 2 years (2018-2019). The likelihood of sepsis-related death was evaluated by clinicians as sepsis-related, possibly sepsis-related, or not sepsis-related. RESULTS: Of 633 hospital deaths, 179 (28%) were sepsis-related, and 136 (21%) were possibly sepsis-related...
March 9, 2023: Infection
Kevin B Laupland, Felicity Edwards, Patrick N A Harris, David L Paterson
PURPOSE: Although Klebsiella aerogenes (formerly Enterobacter aerogenes) and Enterobacter cloacae share many phenotypic characteristics, controversy exists as to whether they cause clinically distinguishable infections. The objective of this study was to determine the comparative incidence, determinants, and outcomes of K. aerogenes and E. cloacae bloodstream infections (BSI). METHODS: Population-based surveillance was conducted among residents aged ≥ 15 years of Queensland, Australia during 2000-2019...
March 7, 2023: Infection
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