Néstor López, Genoveva Cuesta, Sara Rodríguez-Vega, Enric Rosas, Mariana Chumbita, Climent Casals-Pascual, Laura Morata, Andrea Vergara, Marta Bodro, Jordi Bosch, Sabina Herrera, Jose Antonio Martínez, Josep Mensa, Carolina Garcia-Vidal, María Ángeles Marcos, Jordi Vila, Alex Soriano, Pedro Puerta-Alcalde
PURPOSE: We aimed to evaluate the performance of the FilmArray (FA) meningitis/encephalitis (ME) panel. Secondarily, we analyzed the false positive (FP) and false negative (FN) results, as well as the predictive values of the technique, regarding the cerebrospinal fluid (CSF) characteristics. METHODS: FA is a multiplex real-time PCR detecting 14 of the most common ME pathogens in CSF. All FA performed at our hospital (2018-2022) were retrospectively reviewed. FA was compared to conventional techniques and its performance was assessed based on the final diagnosis of the episode...
July 29, 2023: Infection
Juliana Inoue, David Weber, José Francisco Fernandes, Ayola Akim Adegnika, Selidji Todagbe Agnandji, Bertrand Lell, Peter G Kremsner, Martin Peter Grobusch, Benjamin Mordmüller, Jana Held
PURPOSE: Fever is a common cause for hospitalization among the pediatric population. The spectrum of causative agents is diverse. Human herpesvirus 6 (HHV-6) is a ubiquitous virus that often causes hospitalization of children in western countries. Previously, we investigated the cause of fever of 600 febrile hospitalized children in Gabon, and in 91 cases the causative pathogen was not determined. In this study, we assessed HHV-6 infection as potential cause of hospitalization in this group...
July 27, 2023: Infection
Christina König, Melanie Göpfert, Stefan Kluge, Dominic Wichmann
PURPOSE: Posaconazole is an antifungal drug currently being used for prophylaxis and treatment of invasive fungal infections such as aspergillosis. To date, therapeutic drug monitoring (TDM) of posaconazole is recommended with the use of oral suspension, but the potential need of TDM with the use of IV formulations is rising. Therefore, we aimed to investigate the pharmacokinetics of IV posaconazole in critically ill patients. METHODS: In a prospective study, we analysed 168 consecutivelly collected posaconazole levels from 10 critically ill patients drawn during a 7 day curse...
July 27, 2023: Infection
Christoph Boesecke, Sven Schellberg, Jochen Schneider, Gundolf Schuettfort, Hartmut Stocker
PURPOSE: We aimed to review the landscape of late HIV diagnosis in Germany and discuss persisting and emerging barriers to earlier diagnosis alongside potential solutions. METHODS: We searched PubMed for studies informing the prevalence, trends, and factors associated with late HIV diagnosis in Germany. Author opinions were considered alongside relevant data. RESULTS: In Germany, older individuals, heterosexuals, and migrants living with HIV are more likely to be diagnosed late...
July 20, 2023: Infection
Tommaso Manciulli, Davide Marangoni, Joaquin Salas-Coronas, Cristina Bocanegra, Joachim Richter, Federico Gobbi, Leonardo Motta, Andrea Minervini, Alessandro Bartoloni, Lorenzo Zammarchi
BACKGROUND: Currently, there are no standardized guidelines for the diagnosis or management of the complications of urogenital schistosomiasis (UGS). This systematic review of the literature aims to investigate the state of the art in reference to diagnostic approaches and the clinical management of this condition. METHODS: A systematic review of literature published between January 1990 and January 2021 was conducted in the MEDLINE database, scoping for articles regarding diagnostic means or therapeutic options for the complications of UGS, namely obstructive uropathy, bladder cancer, abortion, ectopic pregnancy, infertility, kidney failure, urolithiasis and the need for invasive procedures...
July 19, 2023: Infection
Giulia Gardini, Guenter Froeschl, Francesca Gurrieri, Maria Antonia De Francesco, Chiara Cattaneo, Valentina Marchese, Giorgio Piccinelli, Silvia Corbellini, Chiara Pagani, Marzia Santagiuliana, Benedetta Fumarola, Maurizio Gulletta, Francesca Perandin, Francesco Castelli, Alberto Matteelli
PURPOSE OF THE STUDY: We assessed the prevalence of S. stercoralis in a cohort of inpatients with invasive bacterial infections of enteric origin to investigate whether the parasite may facilitate these bacterial infections even in the absence of larval hyperproliferation. METHODS: We performed a prospective cross-sectional study in a hospital in northern Italy. Subjects admitted due to invasive bacterial infection of enteric origin and potential previous exposure to S...
July 18, 2023: Infection
Selma Tobudic, Christina Bahrs, Lisa Schneider, Emilia Paulussen, Lucie Bartonickova, Stefan Hagel, Peter Starzengruber, Heinz Burgmann, Mathias W Pletz
PURPOSE: This study aimed to compare treatment outcomes for bloodstream infections (BSI) caused by a piperacillin/tazobactam (PIP/TAZ)-susceptible E. coli among three patient groups: BSI caused by ampicillin/sulbactam (AMP/SLB)-resistant isolates treated with PIP/TAZ, BSI caused by AMP/SLB-sensitive isolates treated with PIP/TAZ, and BSI caused by AMP/SLB-resistant isolates treated with another monotherapy. METHODS: This retrospective study was conducted in two academic centres in Europe...
July 18, 2023: Infection
Fridolin Steinbeis, Charlotte Thibeault, Sarah Steinbrecher, Yvonne Ahlgrimm, Ira An Haack, Dietrich August, Beate Balzuweit, Carla Bellinghausen, Sarah Berger, Irina Chaplinskaya-Sobol, Oliver Cornely, Patrick Doeblin, Matthias Endres, Claudia Fink, Carsten Finke, Sandra Frank, Sabine Hanß, Tim Hartung, Johannes Christian Hellmuth, Susanne Herold, Peter Heuschmann, Jan Heyckendorf, Ralf Heyder, Stefan Hippenstiel, Wolfgang Hoffmann, Sebastian Ulrich Kelle, Philipp Knape, Philipp Koehler, Lucie Kretzler, David Manuel Leistner, Jasmin Lienau, Roberto Lorbeer, Bettina Lorenz-Depiereux, Constanze Dorothea Lüttke, Knut Mai, Uta Merle, Lil Antonia Meyer-Arndt, Olga Miljukov, Maximilian Muenchhoff, Moritz Müller-Plathe, Julia Neuhann, Hannelore Neuhauser, Alexandra Nieters, Christian Otte, Daniel Pape, Rafaela Maria Pinto, Christina Pley, Annett Pudszuhn, Philipp Reuken, Siegberg Rieg, Petra Ritter, Gernot Rohde, Maria Rönnefarth, Michael Ruzicka, Jens Schaller, Anne Schmidt, Sein Schmidt, Verena Schwachmeyer, Georg Schwanitz, Werner Seeger, Dana Stahl, Nicole Stobäus, Hans Christian Stubbe, Norbert Suttorp, Bettina Temmesfeld, Sylvia Thun, Paul Triller, Frederik Trinkmann, Istvan Vadasz, Heike Valentin, Maria Vehreschild, Christof von Kalle, Marie von Lilienfeld-Toal, Joachim Weber, Tobias Welte, Christian Wildberg, Robert Wizimirski, Saskia Zvork, Leif Erik Sander, Janne Vehreschild, Thomas Zoller, Florian Kurth, Martin Witzenrath
BACKGROUND: The severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) pandemic causes a high burden of acute and long-term morbidity and mortality worldwide despite global efforts in containment, prophylaxis, and therapy. With unprecedented speed, the global scientific community has generated pivotal insights into the pathogen and the host response evoked by the infection. However, deeper characterization of the pathophysiology and pathology remains a high priority to reduce morbidity and mortality of coronavirus disease 2019 (COVID-19)...
July 11, 2023: Infection
Benjamin T Schleenvoigt, Juliane Ankert, Grit Barten-Neiner, Florian Voit, Norbert Suttorp, Christoph Boesecke, Christian Hoffmann, Daiana Stolz, Mathias W Pletz, Gernot Rohde, Martin Witzenrath, Marcus Panning, Andreas Essig, Jan Rupp, Olaf Degen, Christoph Stephan
OBJECTIVES: The objective of this study was to identify the pathogen spectrum of community acquired pneumonia in people living with HIV (PLWH), and to compare it with a matched HIV negative group in order to reassess therapeutic strategies for PLWH. METHODS: Seventy-three (n = 73) PLWH (median CD4 3-6 months before CAP: 515/µl; SD 309) with community acquired pneumonia (CAP) were matched with 218 HIV-negative CAP controls in a prospective study design...
July 9, 2023: Infection
Agnese Comelli, Camilla Genovese, Federico Gobbi, Gaetano Brindicci, Susanna Capone, Angela Corpolongo, Verena Crosato, Valentina Dianora Mangano, Rosalia Marrone, Maria Merelli, Marco Prato, Carmen Rita Santoro, Salvatore Scarso, Elisa Vanino, Valentina Marchese, Spinello Antinori, Claudio Mastroianni, Annibale Raglio, Fabrizio Bruschi, Andrea Minervini, Daniele Donà, Silvia Garazzino, Luisa Galli, Andrea Lo Vecchio, Andrea Galli, Gabriele Dragoni, Claudio Cricelli, Nicola Colacurci, Enrico Ferrazzi, Annalisa Pieralli, Antonio Montresor, Joachim Richter, Guido Calleri, Alessandro Bartoloni, Lorenzo Zammarchi
No abstract text is available yet for this article.
July 7, 2023: Infection
Benjamin T Schleenvoigt, Anne Moeser, Dragiša Mitić, Michael Baier, Christoph Stephan, Anna Pothmann
No abstract text is available yet for this article.
July 5, 2023: Infection
Matthaios Papadimitriou-Olivgeris, Benoit Guery, Nicoleta Ianculescu, Denise Auberson, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney
PURPOSE: Embolic events (EEs) are a common complication of left-side infective endocarditis (IE). The aim of the present study was to identify risk factors for the occurrence of EEs before or after antibiotic treatment instauration among patients with definite or possible IE. METHODS: This retro-prospective study was conducted at the Lausanne University Hospital, Lausanne, Switzerland, from January 2014 to June 2022. EEs and IE were defined according to modified Duke criteria...
July 4, 2023: Infection
Marlene Ettemeyer, Maria Florey, Konstantin Tanida, Johannes Jochum, Ulf Schulze-Sturm, Marc Lütgehetmann, Michael Baehr, Marylyn M Addo, Stefan Schmiedel, Holger Rohde, Till Koch
PURPOSE: Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and to treat adequately, especially when seasonal viral pathogens co-circulate. The aim of this study was to give a real-world snapshot of the burden of respiratory disease and treatment choices in the emergency department (ED) of a tertiary care hospital in Germany in the fall of 2022. METHODS: Anonymized analysis of a quality control initiative that prospectively documented all patients presenting to our ED with symptoms suggestive of RTI from Nov 7th to Dec 18th, 2022...
July 4, 2023: Infection
Lauge Østergaard, Marianne Voldstedlund, Niels Eske Bruun, Henning Bundgaard, Kasper Iversen, Mia Marie Pries-Heje, Katra Hadji-Turdeghal, Peter L Graversen, Claus Moser, Christian Østergaard Andersen, Kirstine Kobberøe Søgaard, Lars Køber, Emil Loldrup Fosbøl
PURPOSE: In patients surviving infective endocarditis (IE) recurrence of bacteremia or IE is feared. However, knowledge is sparse on the incidence and risk factors for the recurrence of bacteremia or IE. METHODS: Using Danish nationwide registries (2010-2020), we identified patients with first-time IE which were categorized by bacterial species (Staphylococcus aureus, Enterococcus spp., Streptococcus spp., coagulase-negative staphylococci [CoNS], 'Other' microbiological etiology)...
July 3, 2023: Infection
Lorenzo Bertolino, Mohammad Said Ramadan, Rosa Zampino, Emanuele Durante-Mangoni
PURPOSE: Progress of interventional cardiology has boosted the use of newer cardiac devices. These devices are perceived to be less prone to infections compared to traditional surgical prostheses, but little data are currently available. In this systematic review (SR), we summarize current literature regarding the clinical characteristics, management, and outcomes of patients with MitraClip-related infective endocarditis (IE). METHODS: We conducted a SR of PubMed, Google Scholar, Embase, and Scopus between January 2003 and March 2022...
June 29, 2023: Infection
Alaa Atamna, Ili Margalit, Gida Ayada, Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair Macgowan, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesús Rodríguez-Baño, Marina de Cueto, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez-Martinez, Eva M Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstei, Dafna Yahav
BACKGROUND: P. aeruginosa bacteremia is a common and severe infection carrying high mortality in older adults. We aimed to evaluate outcomes of P. aeruginosa bacteremia among old adults (≥ 80 years). METHODS: We included the 464/2394 (19%) older adults from a retrospective multinational (9 countries, 25 centers) cohort study of individuals hospitalized with P. aeruginosa bacteremia. Bivariate and multivariable logistic regression models were used to evaluate risk factors for 30-day mortality among older adults...
August 2023: Infection
Thu Giang Le Thi, Katharina Werkstetter, Kallirroi Kotilea, Patrick Bontems, José Cabral, Maria Luz Cilleruelo Pascual, Michal Kori, Josefa Barrio, Matjaž Homan, Nicolas Kalach, Rosa Lima, Marta Tavares, Pedro Urruzuno, Zrinjka Misak, Vaidotas Urbonas, Sibylle Koletzko
PURPOSE: The EuroPedHp-registry aims to monitor guideline-conform management, antibiotic resistance, and eradication success of 2-week triple therapy tailored to antibiotic susceptibility (TTT) in Helicobacter pylori-infected children. METHODS: From 2017 to 2020, 30 centres from 17 European countries reported anonymized demographic, clinical, antibiotic susceptibility, treatment, and follow-up data. Multivariable logistic regression identified factors associated with treatment failure...
August 2023: Infection
Claudia Stein, Maria Zechel, Riccardo Spott, Mathias W Pletz, Frank Kipp
PURPOSE: Antimicrobial resistance is a pressing issue in Ukraine, with healthcare-associated infections caused by multidrug-resistant organisms being a major concern. A recent prospective multicenter study revealed a staggering rate of 48.4% antimicrobial resistance to carbapenems among Enterobacterales causing a healthcare-associated infection. We conducted a systematic survey to investigate the incidence rate and incidence density of carbapenemase-producing Gram-negative bacteria (CPGN) among refugees and war-wounded Ukrainians in connection with the German health system...
June 20, 2023: Infection
Anselm Jorda, Cornelia Gabler, Amelie Blaschke, Michael Wölfl-Duchek, Georg Gelbenegger, Alina Nussbaumer-Pröll, Christine Radtke, Markus Zeitlinger, Felix Bergmann
BACKGROUND: Bacterial co-infections are believed to be less frequent in patients with Covid-19 than influenza, but frequencies varied between studies. METHODS: This single-center retrospective, propensity score-matched analysis included adult patients with Covid-19 or influenza admitted to normal-care wards between 02/2014 and 12/2021. Covid-19 cases were propensity score matched to influenza cases at a 2:1 ratio. Community-acquired and hospital-acquired bacterial co-infections were defined as positive blood or respiratory cultures ≤ 48 h or > 48 h after hospital admission, respectively...
June 16, 2023: Infection
Martin Christner, Beya Abdennadher, Dominic Wichmann, Stefan Kluge, Amra Pepić, Martin Aepfelbacher, Holger Rohde, Flaminia Olearo
PURPOSE: Beta-D-Glucan (BDG) testing has been suggested to support the diagnosis of candidemia and invasive candidiasis. The actual benefit in critically ill high-risk patients in intensive care units (ICU) has not been verified so far. METHODS: In ICU patients receiving empirical echinocandin treatment for suspected invasive candidiasis (IC), serial BDG testing using the Fujifilm Wako Beta-Glucan Test was performed, starting on the first day of echinocandin administration and every 24-48 h afterwards...
June 15, 2023: Infection
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