Journals Respiration; International Rev...

Respiration; International Review of Thoracic Diseases
Sofie Breuls, Astrid Blondeel, Marieke Wuyts, Geert M Verleden, Robin Vos, Wim Janssens, Thierry Troosters, Heleen Demeyer
Introduction Lung transplant recipients are often physically inactive and are at risk of developing comorbidities. We investigated whether objectively measured physical activity was associated with the prevalence of comorbidities. Methods Physical activity (accelerometry) and the presence of cardiovascular disease, symptoms of depression and anxiety, diabetes, dyslipidaemia, hypertension, lower extremity artery disease, muscle weakness, obesity and osteoporosis were assessed in 108 lung transplant recipients...
March 6, 2024: Respiration; International Review of Thoracic Diseases
Inga Jarosch, Tessa Schneeberger, Antje Stegemann, Rainer Gloeckl, Daniela Leitl, Clancy Dennis, Wolfgang Hitzl, Christopher Schoen, Andreas Rembert Koczulla
INTRODUCTION: To objectify self-reported sleep disorders in individuals with post-COVID-syndrome (PCS), we aimed to investigate the prevalence and nature of sleep disturbances by polysomnography (PSG) in PCS compared to healthy individuals. METHODS: People with PCS (n = 21) and healthy controls (CON, n = 10) were included in this prospective trial. At baseline, clinical and social anamnesis, lung function, 1 min sit-to-stand test (STST) and Pittsburgh Sleep Quality Index (PSQI) were assessed...
March 1, 2024: Respiration; International Review of Thoracic Diseases
Fangqi Cai, Liwei Cheng, Xiaoling Liao, Yuping Xie, Wu Wang, Haofeng Zhang, Jinhua Lu, Ru Chen, Chunxia Chen, Xing Zhou, Xiaoyun Mo, Guoping Hu, Luying Huang
INTRODUCTION: Distinguishing between malignant pleural effusion (MPE) and benign pleural effusion (BPE) poses a challenge in clinical practice. We aimed to construct and validate a combined model integrating radiomic features and clinical factors using computerized tomography (CT) images to differentiate between MPE and BPE. METHODS: A retrospective inclusion of 315 patients with pleural effusion (PE) was conducted in this study (training cohort: n = 220; test cohort: n = 95)...
February 29, 2024: Respiration; International Review of Thoracic Diseases
Maureen van Wincoop, Hazra S Moeniralam, Franz M N H Schramel
Introduction Many COVID-19 survivors suffer from persisting sequelae after acute disease. This is referred to as Long COVID. The objective of this study was to assess factors associated with Long COVID and to analyze differences in persistent symptoms, findings on chest imaging and pulmonary function between intensive care unit (ICU) and non-ICU hospitalized patients. Methods We conducted a retrospective study including patients hospitalized with COVID-19. Patients were stratified into ICU patients and non-ICU patients...
February 28, 2024: Respiration; International Review of Thoracic Diseases
Aida F Martinez, Zachary Tom, David W Hsia, Janine Vintch, Nathan Yee
Pulmonary infections, such as tuberculosis, can result in numerous pleural complications including empyemas, pneumothoraces with broncho-pleural fistulas, and persistent air leak. While definitive surgical interventions are often initially considered, management of these complications can be particularly challenging if a patient has an active infection and is not a surgical candidate. Autologous blood patch pleurodesis and endobronchial valve placement have both been described in remedying persistent air leaks (PALs) effectively and safely...
February 28, 2024: Respiration; International Review of Thoracic Diseases
Brice Touilloux, Alessio Casutt, Marie-Pierre F Strippoli, Alexandra Lenoir, Simone Janett, Peter Vollenweider, Julien Vaucher, Laurent Nicod, Martin Preisig, Christophe Von Garnier
INTRODUCTION: Mental health disorders figure among the many comorbidities of obstructive respiratory diseases. The multisystemic characteristics of chronic respiratory disease and its impact on quality of life could affect depressive and/or anxiety disorders. We aimed to evaluate the association of spirometric indices, ventilatory disorders and self-reported respiratory diseases with psychiatric disorders considering potential confounders. METHODS: We analysed data from CoLaus|PsyCoLaus, a Swiss population-based cohort study, consisting of 2'774 participants (56% women; mean age: 62...
February 28, 2024: Respiration; International Review of Thoracic Diseases
Takuya Okamura, Sayako Morikawa, Tomoya Horiguchi, Kumiko Yamatsuta, Toshikazu Watanabe, Aki Ikeda, Yuri Maeda, Takuma Ina, Hideaki Takahashi, Ryoma Moriya, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Shotaro Okachi, Naozumi Hashimoto, Kazuyoshi Imaizumi
INTRODUCTION: Increasing numbers of cases of mild asymptomatic pulmonary alveolar proteinosis (PAP) are being reported with the recent increase in chest computed tomography (CT). Bronchoscopic diagnosis of mild PAP is challenging because of the patchy distribution of lesions, which makes it difficult to obtain sufficient biopsy samples. Additionally, the pathological findings of mild PAP, particularly those that differ from severe PAP, have not been fully elucidated. This study aimed to clarify the pathological findings of mild PAP and the usefulness of optical biopsy using probe-based confocal laser endomicroscopy (pCLE)...
February 22, 2024: Respiration; International Review of Thoracic Diseases
Julian Müller, Paula Appenzeller, Mona Lichtblau, Stéphanie Saxer, Charlotte Berlier, Simon R Schneider, Michael Furian, Esther I Schwarz, Erik R Swenson, Konrad E Bloch, Silvia Ulrich
INTRODUCTION: Acetazolamide (AZA) improves nocturnal and daytime blood oxygenation in patients with pulmonary vascular disease (PVD), defined as pulmonary arterial and distal chronic thromboembolic pulmonary hypertension (CTEPH), and may improve exercise performance. METHODS: We investigated the effect of 5 weeks of AZA (250 mg bid) versus placebo on maximal load during incremental cycling ramp exercise in patients with PVD studied in a randomized controlled, double-blind, crossover design, separated by > 2 weeks of washout...
February 21, 2024: Respiration; International Review of Thoracic Diseases
Marek Lommatzsch, Parameswaran Nair, Johann Christian Virchow
No abstract text is available yet for this article.
February 14, 2024: Respiration; International Review of Thoracic Diseases
Wen Suna, Qi Zhanga, Xi Wanga, Zhou Jina, Yuan Chenga, Guangfa Wanga
BACKGROUND: Photodynamic therapy (PDT) is a relatively safe and highly selectivity anti-tumor treatment, which might be increasingly used as a supplement to conventional therapies. A clinical overview and detailed comparison of how to select patients and lesions for PDT in different scenarios is urgently needed to provide a basis for clinical treatment. SUMMARY: This review demonstrates the highlights and obstacles of applying PDT for lung cancer, and underlines points worth considering when planning to initiate PDT...
February 14, 2024: Respiration; International Review of Thoracic Diseases
Xiaobo Chen, Wenhao Wang, Yongshun Ye, Yixi Yang, Difei Chen, Ruiting He, Zhulin Xiao, Jingwei Liu, Tingting Xu, Yongna Cai, Haiqi Feng, Changgao Zhong, Weiqun Xiao, Yingying Gu, Liya Lu, Hailin Xiong, Zhiyong Zhang, Shiyue Li
INTRODUCTION: Benign airway stenosis (BAS) is a severe pathologic condition. Complex stenosis has a high recurrence rate and requires repeated bronchoscopic interventions for achieving optimal control, leading to recurrent BAS (RBAS) due to intraluminal granulation. METHODS: This study explored the potential of autologous regenerative factor (ARF) for treating RBAS using a post-intubation tracheal stenosis canine model. Bronchoscopic follow-ups were conducted, and RNA-seq analysis of airway tissue was performed...
February 9, 2024: Respiration; International Review of Thoracic Diseases
Jie Liu, Chun Li, Zilong Liu, Ling Ye, Qinjun Shen, Qunying Hong, Yuanlin Song, Maosong Ye
Bronchopleural fistula (BPF) with empyema caused by severe necrotizing pulmonary infection is a complicated clinical problem that is often associated with poor general condition so surgical interventions cannot be tolerated in most cases. Here, we present the successful management of multiple BPF with empyema in a mechanically ventilated patient with aspiration lung abscess. Occlusion utilizing Gelfoam followed by endobronchial valves (EBVs) implanted inverted via bronchoscope decreased the air leaking significantly and made intrapleural irrigation for empyema achievable and safe...
February 8, 2024: Respiration; International Review of Thoracic Diseases
Jens Spiesshoefer, Simon D Herkenrath, Marcel Treml, Anja Pietzke-Calcagnile, Lars Hagmeyer, Binaya Regmi, Sandhya Matthes, Peter Young, Matthias Boentert, Winfried J Randerath
Introduction Advanced chronic obstructive pulmonary disease (COPD) is associated with chronic hypercapnic failure. The present work aimed to comprehensively investigate inspiratory muscle function as a potential key determinant of hypercapnic respiratory failure in patients with COPD. Methods Prospective patient recruitment encompassed 61 stable subjects with COPD across different stages of respiratory failure ranging from normocapnia to isolated nighttime hypercapnia and daytime hypercapnia. Arterialized blood gas analyses and overnight transcutaneous capnometry were used for patient stratification...
February 7, 2024: Respiration; International Review of Thoracic Diseases
Kotaro Miyake, Takayuki Shiroyama, Shingo Satoh, Yuichi Adachi, Kika Ohira, Yuko Abe, So Takata, Kentaro Masuhiro, Yujiro Naito, Haruhiko Hirata, Izumi Nagatomo, Yoshito Takeda, Atsushi Kumanogoh
INTRODUCTION: In transbronchial biopsy of peripheral pulmonary lesions, the bronchoscope can reach only a limited depth due to the progressive narrowing of bronchi, which may reduce the diagnostic rate. This study examined the balloon dilatation for bronchoscope delivery (BDBD) technique, employing a novel balloon device to enhance bronchoscopy into the peripheral lung areas. METHODS: Anaesthetised swine served as our primary model. Using computed tomography (CT) scans, we positioned virtual targets characterised by a positive bronchus sign and a diameter of 20 mm beneath the pleura...
February 5, 2024: Respiration; International Review of Thoracic Diseases
Sabine Dettmer, Thomas Werncke, Violeta Nikolova Mitkovska, Torben Brod, Oana Joean, Jens Vogel-Claussen, Frank Wacker, Tobias Welte, Jessica Rademacher
INTRODUCTION: Photon counting (PC) detectors allow a reduction of the radiation dose in CT. Chest X-ray (CXR) is known to have a low sensitivity and specificity for detection of pneumonic infiltrates. The aims were to establish an ultra-low-dose CT (ULD-CT) protocol at a PC-CT with the radiation dose comparable to the dose of a CXR and to evaluate its clinical yield in patients with suspicion of pneumonia. METHODS: A ULD-CT protocol was established with the aim to meet the radiation dose of a CXR...
January 25, 2024: Respiration; International Review of Thoracic Diseases
Morten Borg, Katrine Kristensen, Gitte Alstrup, Tatiana Mamaeva, Arman Arshad, Christian B Laursen, Ole Hilberg, Uffe Bodtger, Michael Brun Andersen, Torben Riis Rasmussen
INTRODUCTION: Lung cancer is the leading cause of cancer-related death globally. Incidental pulmonary nodules represent a golden opportunity for early diagnosis, which is critical for improving survival rates. This study explores the impact of missed pulmonary nodules on the progression of lung cancer. METHODS: A total of 4,066 stage IV lung cancer cases from 2019 to 2021 in Danish hospitals were investigated to determine whether a chest computed tomography (CT) had been performed within 2 years before diagnosis...
January 22, 2024: Respiration; International Review of Thoracic Diseases
Mei Yang, Yao Lv, Shijie Tang, Dan Xu, Diandian Li, Zenglin Liao, Xiaoou Li, Lei Chen
INTRODUCTION: Blood eosinophil count has been shown markedly variable across different populations. However, its distribution in Chinese general population remains unclear. We aimed to investigate blood eosinophil count and its determinants in a Chinese general population. METHODS: In this population-based study, general citizens of Sichuan province in China were extracted from the China Pulmonary Health study. Data on demographics, personal and family history, living condition, lifestyle, spirometry, and complete blood count test were obtained and analyzed...
January 22, 2024: Respiration; International Review of Thoracic Diseases
Simon Lindner, Jan Teichert, Clara Hoermann, Julia D Michels, Felix J F Herth, Daniel Duerschmied, Simone Britsch
INTRODUCTION: The most widespread treatment for obstructive sleep apnoea and obesity hypoventilation syndrome is continuous positive airway pressure (CPAP). The addition of inspiratory support is a potential alternative. This is a physiological study to determine the effect of CPAP and inspiratory support pressure on respiratory effort measured by diaphragm thickening fraction (DTF) in healthy volunteers. METHODS: DTF was measured in spontaneously breathing, healthy volunteers during 4 phases: (I) without connection to a ventilator, (II) on a ventilator without any applied pressures, (III) with a CPAP of 5 cmH2O, and (IV) with an additional inspiratory support pressure of 5 cmH2O...
January 16, 2024: Respiration; International Review of Thoracic Diseases
Simone Mennella, Cristiano Alicino, Marco Anselmo, Giuliana Carrega, Gianluca Ficarra, Luca Garra, Alessandro Gastaldo, Paola Gnerre, Flavia Lillo, Rodolfo Tassara, Anna Terrile, Manlio Milanese
INTRODUCTION: Serial follow-up with pulmonary function testing (PFT) and chest computed tomography (CT) after severe COVID-19 are recommended. As a result, many longitudinal studies have been published on COVID-19 of different grade of severity up to 1-year follow-up. Therefore, we aimed at a long-term observational study throughout 2 years after severe COVID-19. METHODS: Severe COVID-19 patients were consecutively recruited after hospital discharge between March and June 2020 and prospectively followed up for 24 months, with mMRC dyspnea scale and PFT at 6, 12, and 24 months...
January 9, 2024: Respiration; International Review of Thoracic Diseases
Thibaud Soumagne, Hervé Dutau, Georgie Eapen, Nicolas Guibert, Christopher Hergott, Fabien Maldonado, Hideo Saka, Marc Fortin
INTRODUCTION: The investigation of peripheral pulmonary lesions (PPLs) can be challenging. Several bronchoscopic modalities have been developed to reach and biopsy PPL but the level of adoption of these techniques by interventional pulmonologists (IPs) is unknown. This international survey was conducted to describe current practices in PPL investigation among IP. METHODS: This survey was sent to all members of the World Association for Bronchology and Interventional Pulmonology, Canadian Thoracic Society Procedures Assembly, AABIP, and the Groupe d'Endoscopie Thoracique et Interventionnel Francophone...
2024: Respiration; International Review of Thoracic Diseases
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