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Surgical Oncology

Nicole Carreau, Anna Pavlick
Until immunotherapy was developed, a diagnosis of metastatic melanoma was most often fatal. Programmed death receptor-1 (PD-1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibodies have been shown to work synergistically to treat metastatic disease throughout the body and brain. Today, over half of patients diagnosed with stage IV disease are alive after 3 years. In the adjuvant setting, 70% patients remain disease free with PD-1 blockade after 1 year. These treatments are generally safe and well tolerated...
January 12, 2019: Surgical Oncology
Xiaomei Yao, Emily Vella, Melissa Brouwers
This is the third article of our educational series, which focuses on how to conduct a high-quality original study on a prognostic research topic from a methodological perspective. We introduce four aspects: clarifying the objectives; generating an appropriate research question; planning the study; and reporting and analyzing data. This paper has several highlights. (1) There are four types of prognostic studies: Type I-fundamental prognostic research, Type II-prognostic factors research, Type III-prediction model research, and Type IV-stratified medicine research...
December 2018: Surgical Oncology
Florent Milliet, Jocelyn Gal, Emmanuel Chamorey, Olivier Dassonville, Gilles Poissonnet, Frédéric Peyrade, Karen Benezery, Raphaël Hechema, Anne Sudaka, Marine Sanchez-Luini, François Demard, José Santini, Alexandre Bozec
OBJECTIVES: To evaluate the clinical outcomes of total pharyngolaryngectomy (TPL) in the elderly and to analyze the impact of age on postoperative complications and oncologic and functional outcomes. METHODS: We conducted a retrospective review of the medical records of all patients who underwent TPL for a laryngeal or hypopharyngeal squamous cell carcinoma, between 2000 and 2015. The impact of advanced age (>70 years) on clinical outcomes was assessed in univariate and multivariate analyses...
December 2018: Surgical Oncology
Alexandre Thobie, Andrea Mulliri, Nathan Dolet, Yassine Eid, Véronique Bouvier, Guy Launoy, Arnaud Alves, Olivier Dejardin
BACKGROUND: Survival of patients with pancreatic adenocarcinoma (PA) is very poor. Resection status is highly associated with prognosis but only 15%-20% are resectable. The aim of this study was to analyse the impact of socioeconomic deprivation on PA survival and to define which management steps are affected. METHODS: Between 01/01/2000 and 31/12/2014, 1451 incident cases of PA recorded in the digestive cancer registry of the French department of Calvados were included...
December 2018: Surgical Oncology
Andreas Andreou, Benjamin Struecker, Nathanael Raschzok, Felix Krenzien, Philipp Haber, Simon Wabitsch, Christoph Waldbaur, Eva-Maria Touet, Anne-Christine Eichelberg, Georgi Atanasov, Matthias Biebl, Marcus Bahra, Robert Öllinger, Moritz Schmelzle, Johann Pratschke
BACKGROUND: Minimal-invasive hepatectomy (MIH) has been increasingly performed for benign and malignant liver lesions with most promising results. However, the role of MIH for the treatment of patients with hepatocellular carcinoma (HCC) needs further investigation. METHODS: Clinicopathological data of patients who underwent liver resection for HCC between 2005 and 2016 were assessed. Postoperative outcomes und long-term survivals of patients following MIH were compared with those of patients undergoing conventional open hepatectomy (OH) after 1:1 propensity score matching...
December 2018: Surgical Oncology
Hiroo Suami, Louise Koelmeyer, Helen Mackie, John Boyages
Upper extremity lymphoedema after axillary node dissection is an iatrogenic disease particularly associated with treatment for breast or skin cancer. Anatomical studies and lymphangiography in healthy subjects identified that axillary node dissection removes a segment of the lymphatic drainage pathway running from the upper limb to the sub-clavicular vein, creating a surgical break. It is reasonable to infer that different patterns of lymphatic drainage may occur in the upper limb following surgery and contribute to the various presentations of lymphoedema from none to severe...
December 2018: Surgical Oncology
Liang Chen, Qiang Zhang, Feng-Yuan Li, Li Yang, Dian-Cai Zhang, Lin-Jun Wang, Wei-Zhi Wang, Zheng Li, Jiang-Hao Xu, Zhong-Yuan He, Kang-Jing Xu, Ming Chen, Hao Xu, Ze-Kuan Xu
BACKGROUND: Complete surgical resection remains the predominant treatment modality for primary gastrointestinal stromal tumors (GISTs). No therapeutic consensus exists for 2-5 cm gastric GISTs. We compared the efficacy, safety, and prognosis of laparoscopic and endoscopic surgeries in the treatment of relatively small (2-5 cm) intraluminal gastric GISTs. METHODS: We collected 101 patients with relatively small intraluminal gastric GISTs who had integrated clinicopathological data and underwent laparoscopic or endoscopic resection (laparoscopic group n = 66; endoscopic group n = 35)...
December 2018: Surgical Oncology
Winesh Ramphal, Jeske R E Boeding, Paul D Gobardhan, Harm J T Rutten, Leandra J M Boonman de Winter, Rogier M P H Crolla, Jennifer M J Schreinemakers
INTRODUCTION: Anastomotic leakage is one of the most severe early complications after colorectal surgery, and it is associated with a high reoperation rate-, and increased in short-term morbidity and mortality rates. It remains unclear whether anastomotic leakage is associated with poor oncologic outcomes. The aim of this study was to determine the impacts of anastomotic leakage on long-term oncologic outcomes, disease-free survival and overall mortality in patients who underwent curative surgery for colorectal cancer...
December 2018: Surgical Oncology
Stefano Di Sandro, Vincenzo Bagnardi, Marc Najjar, Vincenzo Buscemi, Andrea Lauterio, Riccardo De Carlis, Maria Danieli, Enrico Pinotti, Laura Benuzzi, Luciano De Carlis
BACKGROUND: Laparoscopic liver resection (LLR) has gained significant popularity over the last 10 years. First experiences of LLR compared to open liver resection (OLR) reported a similar survival and a better safety profile for LLR. MATERIALS AND METHODS: This is a retrospective analysis of prospectively collected data of all consecutive patients treated by liver resection for HCC on liver cirrhosis between January 2005 and March 2017. The choice of procedure (LLR vs OLR) was generally based on tumor localization, history of previous upper abdominal surgery and patient's preference...
December 2018: Surgical Oncology
Laetitia Gambotti, Emilie Schwob, Thomas Schouman, Gregory Murcier, Patrick Goudot, Alain Mallet, Chloé Bertolus
OBJECTIVES: There is no consensus for the specific management of elderly patients presenting with oral cavity squamous cell carcinomas (OC SCC). We report our findings in the treatment of primary OC SCC, for patients of 70 years of age or more, in a French university hospital center. PATIENTS AND METHODS: One hundred and twenty five patients diagnosed between 2000 and 2010, were included retrospectively. Independent risk factors of post-operative complications were identified using a logistic regression...
December 2018: Surgical Oncology
Parita Sanghani, Beng Ti Ang, Nicolas Kon Kam King, Hongliang Ren
Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. In this study, MR image derived texture features, tumor shape and volumetric features, and patient age were obtained for 163 patients...
December 2018: Surgical Oncology
Galina Chernaya, Nina Mikhno, Tatiana Khabalova, Svetlana Svyatchenko, Lyudmila Mostovich, Sergey Shevchenko, Lyudmila Gulyaeva
Thyroid cancer (TC) is one of the most common malignancy of the human endocrine system. BRAF V600E mutation is the most frequent genetic alteration of papillary carcinoma, the most frequent TC, which effects RAS-RAF-MEK intracellular signaling pathway. These alterations in RAS-RAF-MEK pathway lead to changes in expression levels of cell membrane integrin receptors and their ligand - extracellular matrix protein osteopontin, which in turn increases the metastatic potential of tumor cells. Thus, integrins and their ligand osteopontin can be considered as potential biomarkers of tumor progression and aggressive tumor phenotypes...
December 2018: Surgical Oncology
A J Rueten-Budde, V M van Praag, M A J van de Sande, M Fiocco
PURPOSE: There is increasing interest in personalized prediction of disease progression for soft tissue sarcoma patients. Currently, available prediction models are limited to predictions from time of surgery or diagnosis. This study updates predictions of overall survival at different times during follow-up by using the concept of dynamic prediction. PATIENTS AND METHODS: Information from 2232 patients with high-grade extremity soft tissue sarcoma, who underwent surgery at 14 specialized sarcoma centers, was used to develop a dynamic prediction model...
December 2018: Surgical Oncology
Andreas Andreou, Sebastian Knitter, Fritz Klein, Thomas Malinka, Moritz Schmelzle, Benjamin Struecker, Rosa B Schmuck, Alina Roxana Noltsch, Daniela Lee, Uwe Pelzer, Timm Denecke, Johann Pratschke, Marcus Bahra
BACKGROUND: The role of hepatectomy for patients with liver metastases from ductal adenocarcinoma of the pancreas (PLM) remains controversial. Therefore, the aim of our study was to examine the postoperative morbidity, mortality, and long-term survivals after liver resection for synchronous PLM. METHODS: Clinicopathological data of patients who underwent hepatectomy for PLM between 1993 and 2015 were assessed. Major endpoint of this study was to identify predictors of overall survival (OS)...
December 2018: Surgical Oncology
Esther Paredes-Aracil, Antonio Palazón-Bru, David Manuel Folgado-de la Rosa, José Ramón Ots-Gutiérrez, Cristina Llorca-Ferrándiz, Sonia Alonso-Hernández, José Vicente Coloma-Lidón, Vicente Francisco Gil-Guillén
OBJECTIVE: Current breast cancer recurrence prediction models have limitations for clinical practice (statistical methodology, simplicity and specific populations). We therefore developed a new model that overcomes these limitations. METHODS: This cohort study comprised 272 patients with breast cancer followed between 2003 and 2016. The main variable was time-to-recurrence (locoregional and/or metastasis) and secondary variables were its risk factors: age, postmenopause, grade, oestrogen receptor, progesterone receptor, c-erbB2 status, stage, multicentricity, diagnosis and treatment...
December 2018: Surgical Oncology
Linda M Youngwirth, Kyle Freischlag, Daniel P Nussbaum, Ehsan Benrashid, Dan G Blazer
INTRODUCTION: Primary sarcomas of the pancreas are rare, and the limited data regarding their presentation, oncologic profile, and survival have been derived from small case series. METHODS: The National Cancer Data Base (1998-2012) was queried for patients with primary sarcomas of the pancreas. Demographic and clinical features at the time of diagnosis were evaluated for all patients. Subjects who underwent surgical resection were identified, and logistic regression was used to identify variables associated with resection...
December 2018: Surgical Oncology
Marcel Autran Machado, Rodrigo Surjan, Tiago Bassères, Fabio Makdissi
No abstract text is available yet for this article.
December 2018: Surgical Oncology
Markus Bo Schoenberg, Hubertus Johann Wolfgang Anger, Jingcheng Hao, Adrian Vater, Julian Nikolaus Bucher, Michael Nikolaus Thomas, Michael Lauseker, Markus Rentsch, Tobias Simon Schiergens, Martin Kurt Angele, Alexandr V Bazhin, Jens Werner, Markus Otto Guba
OBJECTIVE: To develop criteria for safe and oncologically satisfying liver resection in case of early hepatocellular carcinoma with a 5-year overall survival (OS) similar to liver transplantation. SUMMARY BACKGROUND DATA: Liver resection (LR) and liver transplantation (LT) are potentially curative treatment options for hepatocellular carcinoma. Generally, LT achieves better OS. Due to organ shortage, however not all patients can receive a LT. METHODS: To decide which patients to resect and which to transplant we have developed biological resection criteria (BRC) as a compound out of mGPS (modified Glascow Prognostic Scale) and the Kings-Score (for HCV cirrhosis)...
December 2018: Surgical Oncology
Gabriel Liberale, Paul H Sugarbaker
Sclerosing encapsulating peritonitis (SEP) is a rare entity characterized by encapsulation of the small bowel and/or the colon by a fibrous tissue that forms a shell. Intraperitoneal chemotherapy (IPC) has been reported to be a potential causative factor of secondary SEP. However, few studies have reported on secondary SEP related to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Here, we review results from four clinical cases of SEP associated with CRS and HIPEC. In all four patients, additional surgery was necessary to alleviate recurrent episodes of small bowel obstruction...
December 2018: Surgical Oncology
Karol Rawicz-Pruszyński, Johanna Wilhelmina van Sandick, Jerzy Mielko, Bogumiła Ciseł, Wojciech P Polkowski
Gastric cancer (GC) remains one of the most common causes of cancer death worldwide with expected 5-year survival rates around 25% in Western countries. In order to improve treatment strategy, a most effective staging process should be completed. A novel TNM staging for GC has been proposed recently, along with a separate staging system for GC patients who underwent preoperative therapy (ypStage). Availability of high-quality imaging and access to diagnostic laparoscopy with lavage cytology should be applied while planning the multimodal therapy...
December 2018: Surgical Oncology
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