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JOURNAL ARTICLE
Melanie Sloan, Thomas A Pollak, Efthalia Massou, Guy Leschziner, Laura Andreoli, Rupert Harwood, Michael Bosley, Mervi Pitkanen, Wendy Diment, Alessandra Bortoluzzi, Michael S Zandi, Mandeep Ubhi, Caroline Gordon, David Jayne, Felix Naughton, Colette Barrere, Chris Wincup, James Brimicombe, James A Bourgeois, David D'Cruz
OBJECTIVE: Attribution of neuropsychiatric symptoms in systemic lupus erythematosus (SLE) relies heavily on clinician assessment. Limited clinic time, variable knowledge, and symptom under-reporting contributes to discordance between clinician assessments and patient symptoms. We obtained attributional data directly from patients and clinicians in order to estimate and compare potential levels of direct attribution to SLE of multiple neuropsychiatric symptoms using different patient-derived measures...
March 22, 2024: Rheumatology
#62
JOURNAL ARTICLE
Simin Liao, Liuquan Cheng, Zheng Zhao, Xiaojian Ji, Jianglin Zhang, Jian Zhu, Feng Huang
OBJECTIVE: To quantitatively analyze the morphological characteristics of osteophytes in DISH and syndesmophytes in AS, and summarize different ossification patterns to help identify the two diseases. Associated factors for new bone formation would be investigated. METHODS: Fifty patients with DISH and 50 age-, sex-, CT examination site- matched patients with AS were enrolled. Radiographic and clinical data were reviewed. Osteophytes (syndesmophytes) in front of each vertebral body and the corresponding intervertebral disc space were defined as vertebral osteophytes unit (VOU)...
March 22, 2024: Rheumatology
#63
JOURNAL ARTICLE
Anastasia-Georgia Dedemadi, Christina Gkolfinopoulou, Dimitra Nikoleri, Myrto Nikoloudaki, Hanna Ruhanen, Minna Holopainen, Reijo Kakela, Georgia Christopoulou, Stavros Bournazos, Pantelis Constantoulakis, Prodromos Sidiropoulos, George Bertsias, Angeliki Chroni
OBJECTIVE: Chronic inflammatory diseases, like Systemic Lupus Erythematosus (SLE), carry an increased risk for atherosclerosis and cardiovascular events, accompanied by impairment of atheroprotective properties of high-density lipoprotein (HDL). In SLE, serum BAFF (B cell-activating factor), a cytokine implicated in disease progression, has been correlated with subclinical atherosclerosis. We investigated the impact of treatment with belimumab -an anti-BAFF monoclonal antibody- on HDL atheroprotective properties and composition in SLE patients...
March 21, 2024: Rheumatology
#64
JOURNAL ARTICLE
Valeria Rios Rodriguez, Murat Torgutalp, Fabian Proft, Judith Rademacher, Mikhail Protopopov, Laura Spiller, Hildrun Haibel, Joachim Sieper, Denis Poddubnyy
OBJECTIVE: To assess the association of body composition, evaluated by bioimpedance analysis (BIA), with disease activity, physical function, and mobility in patients with axSpA undergoing bDMARD treatment for one year. METHODS: Patients with AS (radiographic axSpA) were enrolled in an extension of the German Spondyloarthritis Inception Cohort (GESPIC). Patients were required to be candidates for bDMARD therapy at baseline presenting high disease activity despite previous treatment with nonsteroidal anti-inflammatory drugs...
March 20, 2024: Rheumatology
#65
JOURNAL ARTICLE
Minkyung Han, Jang Woo Ha, Inkyung Jung, Chi Young Kim, Sung Soo Ahn
BACKGROUND: Tuberculosis (TB) is a highly prevalent disease associated with significant morbidity and mortality globally, and is reported to be associated with the onset of autoimmunity. This study investigated the association between TB and the incidence of systemic vasculitides (SV). METHODS: Data were obtained from the South Korean National Claims database to identify patients with TB and controls (who had undergone appendectomy). The overall occurrence of SV and disease subtypes during the observation period was compared between the two groups...
March 20, 2024: Rheumatology
#66
JOURNAL ARTICLE
Xia Lyu, Janine A Lamb, Hector Chinoy
WD repeat- and FYVE domain-containing protein 4 (WDFY4), coded by a gene on 10q11.23, is a member of the BEACH (Beige and Chediak-Higashi) domain-containing family. Genome-wide association studies identified WDFY4 variants as a risk factor for SLE in Asian and European populations. WDFY4 variants are also associated with RA and primary biliary cholangitis, in different ancestry populations. The WDFY4 protein plays an essential role in the cross-presentation of classic dendritic cells, reactive oxygen species-induced apoptosis of CD8+ T cells, and non-canonical autophagic activity in B cells...
March 20, 2024: Rheumatology
#67
JOURNAL ARTICLE
Hiroya Tamai, Yasushi Kondo, Tsutomu Takeuchi, Yuko Kaneko
OBJECTIVES: Tocilizumab, an IL-6 inhibitor, has been proven effective in patients with adult-onset Still's disease (AOSD). This study aimed to clarify whether tocilizumab can be discontinued after achieving remission and to identify factors relevant to its successful discontinuation. METHODS: Consecutive patients with AOSD diagnosed according to Yamaguchi's criteria from April 2012 to July 2022, who were treated with tocilizumab, were retrospectively reviewed. RESULTS: Forty-eight patients with AOSD treated with intravenous tocilizumab, with sufficient information, were included...
March 20, 2024: Rheumatology
#68
JOURNAL ARTICLE
Francesco Muratore, Chiara Marvisi, Luigi Boiardi, Paolo Giorgi Rossi, Carlo Salvarani
No abstract text is available yet for this article.
March 20, 2024: Rheumatology
#69
JOURNAL ARTICLE
Anne M Kerola, Antti Palomäki, Hannele Laivuori, Tarja Laitinen, Martti Färkkilä, Kari K Eklund, Samuli Ripatti, Markus Perola, Andrea Ganna, Joni V Lindbohm, Nina Mars
OBJECTIVES: Rheumatic diseases may impair reproductive success and pregnancy outcomes, but systematic evaluations across diseases are lacking. We conducted a nationwide cohort study to examine the impact of rheumatic diseases on reproductive health measures, comparing the impacts with those of other immune-mediated diseases (IMDs). METHODS: Out of all of the 5 339 804 Finnish citizens, individuals born 1964-1984 and diagnosed with any of the 19 IMDs before age 30 (women) or 35 (men) were matched with 20 controls by birth year, sex, and education...
March 20, 2024: Rheumatology
#70
(no author information available yet)
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#71
JOURNAL ARTICLE
Huong D Nguyen, Fabienne Jouen, Benoit Déchelotte, Nadège Cordel, Cyril Gitiaux, Christine Bodemer, Pierre Quatier, Alexandre Belot, Kathryn O'Brien, Dario Cancemi, Isabelle Melki, Nicole Fabien, Sarah Tansley, Olivier Boyer, Lucy R Wedderburn, Brigitte Bader-Meunier
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#72
JOURNAL ARTICLE
Despoina N Maritsi, Ioannis Kopsidas, Panagiota Tsagkli, Maria N Tsolia
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#73
JOURNAL ARTICLE
Line R Knudsen, Mwidimi Ndosi, Ellen-Margrethe Hauge, Kirsten Lomborg, Lene Dreyer, Sidsel Aaboe, Marie B Kjær, Lis Sørensen, Lena Volsmann, Heidi M Christensen, Annette de Thurah
OBJECTIVES: To evaluate the effectiveness of a novel digital patient education (PE) programme in improving self-management in patients newly diagnosed with rheumatoid arthritis (RA). METHODS: This was a parallel, open-label, two arms, randomised controlled trial with superiority design. Patients from five rheumatology clinics were randomised into digital PE (intervention) or face-to-face PE (control). The primary outcome was self-efficacy, measured by average difference in the Rheumatoid Arthritis Self-Efficacy (RASE) score from baseline to month 12...
March 18, 2024: Rheumatology
#74
JOURNAL ARTICLE
Nicolas Lozachmeur, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas M Silva, Alexandre Nguyen, Sophie Gallou, Rémi Philip, Achille Aouba, Hubert de Boysson
OBJECTIVES: To assess the frequency and characteristics of severe relapse in patients with giant cell arteritis (GCA) in a real-life setting. METHODS: In a monocentric database of 530 patients, we retrospectively analysed patients who experienced at least one relapse and distinguished severe from nonsevere relapses. Severe relapse was defined by the occurrence of an ischaemic event (ophthalmologic, neurologic, digestive, limb ischaemia), the occurrence of an aortic complication (i...
March 18, 2024: Rheumatology
#75
JOURNAL ARTICLE
Laura C Coates, Marwan Bukhari, Antoni Chan, Ernest Choy, James Galloway, Nicola Gullick, Alison Kent, Laura Savage, Stefan Siebert, William Tillett, Natasha Wood, Philip G Conaghan
OBJECTIVES: Existing guidelines for psoriatic arthritis (PsA) cover many aspects of management. Some gaps remain relating to routine practice application. An expert group aimed to enhance current guidance and develop recommendations for clinical practice that are complementary to existing guidelines. METHODS: A steering committee comprising experienced, research-active clinicians in rheumatology, dermatology and primary care agreed on themes and relevant questions...
March 15, 2024: Rheumatology
#76
JOURNAL ARTICLE
Sakir Ahmed, Soumendu Mahapatra, Rasmita Mishra, Krushna Chandra Murmu, Prasanta Padhan, Punit Prasad, Ramnath Misra
OBJECTIVES: Reactive arthritis (ReA) provides a unique opportunity to comprehend how a mucosal infection leads to inflammatory arthritis at a distant site without the apparent invasion of the pathogen. Unfortunately, conventional stool cultures after ReA provide limited information, and there is a dearth of metagenomic studies in ReA. The objective of this study was to identify gut microbiota associated with the development of ReA. METHODS: Patients with ReA or undifferentiated peripheral spondyloarthritis (UpSpA) were included if they presented within 4 weeks of the onset of the current episode of arthritis...
March 15, 2024: Rheumatology
#77
JOURNAL ARTICLE
Irene Altabás-González, José María Pego-Reigosa, Coral Mouriño, Norman Jiménez, Andrea Hernández-Martín, Ivette Casafont-Solé, Judit Font Urguelles, José Andrés Román-Ivorra, Marta de la Rubia Navarro, María Galindo-Izquierdo, Tarek Carlos Salman-Monte, Javier Narváez, Paola Vidal-Montal, María Jesús García-Villanueva, Sandra Garrote-Corral, María Ángeles Blázquez-Cañamero, Carlos Marras, María Piqueras-García, Julia Martínez-Barrio, Marina Sánchez-Lucas, Josefina Cortés-Hernández, Eleonora Penzo, Jaime Calvo, Juan Ramón de Dios, Belén Álvarez Rodríguez, Margarida Vasques-Rocha, Eva Tomero, Raúl Menor-Almagro, Myriam Gandía, José A Gómez-Puerta, Beatriz Frade-Sosa, Consuelo Ramos-Giráldez, Carmen Trapero-Pérez, Elvira Diez, Clara Moriano, Alejandro Muñoz-Jiménez, Iñigo Rúa-Figueroa
OBJECTIVES: To provide an overview on the current use of belimumab (BLM) in SLE patients in clinical practice and to examine its efficacy in terms of standardized outcomes, drug survival, as well as patient and safety profiles. METHODS: A longitudinal retrospective multicentre cohort including SLE patients treated with BLM at 18 Spanish centers. Data was collected upon initiation of BLM, at 6 and 12 months after initiation, and at the last recorded visit...
March 15, 2024: Rheumatology
#78
JOURNAL ARTICLE
Ai Kuzumi, Ayumi Yoshizaki, Ruriko Kawanabe, Shinichi Sato
No abstract text is available yet for this article.
March 14, 2024: Rheumatology
#79
JOURNAL ARTICLE
Amy Fuller, Jennie Hancox, Hywel C Williams, Tim Card, Maarten W Taal, Guruprasad P Aithal, Christopher P Fox, Christian D Mallen, James R Maxwell, Sarah Bingham, Kavita Vedhara, Abhishek Abhishek
OBJECTIVE: To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). METHODS: Adults (≥18 years) taking immune-suppressing treatment(s) for at-least six months, and healthcare professionals (HCPs) with experience of either prescribing and/or monitoring immune-suppressing drugs were invited to participate in a single, remote, one-to-one, semi-structured interview...
March 14, 2024: Rheumatology
#80
JOURNAL ARTICLE
Veronica Venturelli, Beatrice Maranini, Ibrahim Tohidi-Esfahani, David A Isenberg, Hannah Cohen, Maria Efthymiou
APS is an autoimmune disorder with life-threatening complications that, despite therapeutic advantages, remains associated with thrombotic recurrences and treatment failure. The role of complement activation in APS pathogenesis is increasingly recognised, specifically in obstetric APS. However, its exact role in thrombotic APS and on the severity of the disease is not yet fully elucidated. Further mechanistic studies are needed to delineate the role of complement activation in the various APS clinical manifestations with aim to identify novel markers of disease severity, together with clinical trials to evaluate the efficacy of complement inhibition in APS...
March 14, 2024: Rheumatology
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