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March 18, 2024: Rheumatology
#82
JOURNAL ARTICLE
Huong D Nguyen, Fabienne Jouen, Benoit Déchelotte, Nadège Cordel, Cyril Gitiaux, Christine Bodemer, Pierre Quatier, Alexandre Belot, Kathryn O'Brien, Dario Cancemi, Isabelle Melki, Nicole Fabien, Sarah Tansley, Olivier Boyer, Lucy R Wedderburn, Brigitte Bader-Meunier
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#83
JOURNAL ARTICLE
Despoina N Maritsi, Ioannis Kopsidas, Panagiota Tsagkli, Maria N Tsolia
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#84
JOURNAL ARTICLE
Line R Knudsen, Mwidimi Ndosi, Ellen-Margrethe Hauge, Kirsten Lomborg, Lene Dreyer, Sidsel Aaboe, Marie B Kjær, Lis Sørensen, Lena Volsmann, Heidi M Christensen, Annette de Thurah
OBJECTIVES: To evaluate the effectiveness of a novel digital patient education (PE) programme in improving self-management in patients newly diagnosed with rheumatoid arthritis (RA). METHODS: This was a parallel, open-label, two arms, randomised controlled trial with superiority design. Patients from five rheumatology clinics were randomised into digital PE (intervention) or face-to-face PE (control). The primary outcome was self-efficacy, measured by average difference in the Rheumatoid Arthritis Self-Efficacy (RASE) score from baseline to month 12...
March 18, 2024: Rheumatology
#85
JOURNAL ARTICLE
Nicolas Lozachmeur, Anael Dumont, Samuel Deshayes, Jonathan Boutemy, Gwénola Maigné, Nicolas M Silva, Alexandre Nguyen, Sophie Gallou, Rémi Philip, Achille Aouba, Hubert de Boysson
OBJECTIVES: To assess the frequency and characteristics of severe relapse in patients with giant cell arteritis (GCA) in a real-life setting. METHODS: In a monocentric database of 530 patients, we retrospectively analysed patients who experienced at least one relapse and distinguished severe from nonsevere relapses. Severe relapse was defined by the occurrence of an ischaemic event (ophthalmologic, neurologic, digestive, limb ischaemia), the occurrence of an aortic complication (i...
March 18, 2024: Rheumatology
#86
JOURNAL ARTICLE
Laura C Coates, Marwan Bukhari, Antoni Chan, Ernest Choy, James Galloway, Nicola Gullick, Alison Kent, Laura Savage, Stefan Siebert, William Tillett, Natasha Wood, Philip G Conaghan
OBJECTIVES: Existing guidelines for psoriatic arthritis (PsA) cover many aspects of management. Some gaps remain relating to routine practice application. An expert group aimed to enhance current guidance and develop recommendations for clinical practice that are complementary to existing guidelines. METHODS: A steering committee comprising experienced, research-active clinicians in rheumatology, dermatology and primary care agreed on themes and relevant questions...
March 15, 2024: Rheumatology
#87
JOURNAL ARTICLE
Sakir Ahmed, Soumendu Mahapatra, Rasmita Mishra, Krushna Chandra Murmu, Prasanta Padhan, Punit Prasad, Ramnath Misra
OBJECTIVES: Reactive arthritis (ReA) provides a unique opportunity to comprehend how a mucosal infection leads to inflammatory arthritis at a distant site without the apparent invasion of the pathogen. Unfortunately, conventional stool cultures after ReA provide limited information, and there is a dearth of metagenomic studies in ReA. The objective of this study was to identify gut microbiota associated with the development of ReA. METHODS: Patients with ReA or undifferentiated peripheral spondyloarthritis (UpSpA) were included if they presented within 4 weeks of the onset of the current episode of arthritis...
March 15, 2024: Rheumatology
#88
JOURNAL ARTICLE
Irene Altabás-González, José María Pego-Reigosa, Coral Mouriño, Norman Jiménez, Andrea Hernández-Martín, Ivette Casafont-Solé, Judit Font Urguelles, José Andrés Román-Ivorra, Marta de la Rubia Navarro, María Galindo-Izquierdo, Tarek Carlos Salman-Monte, Javier Narváez, Paola Vidal-Montal, María Jesús García-Villanueva, Sandra Garrote-Corral, María Ángeles Blázquez-Cañamero, Carlos Marras, María Piqueras-García, Julia Martínez-Barrio, Marina Sánchez-Lucas, Josefina Cortés-Hernández, Eleonora Penzo, Jaime Calvo, Juan Ramón de Dios, Belén Álvarez Rodríguez, Margarida Vasques-Rocha, Eva Tomero, Raúl Menor-Almagro, Myriam Gandía, José A Gómez-Puerta, Beatriz Frade-Sosa, Consuelo Ramos-Giráldez, Carmen Trapero-Pérez, Elvira Diez, Clara Moriano, Alejandro Muñoz-Jiménez, Iñigo Rúa-Figueroa
OBJECTIVES: To provide an overview on the current use of belimumab (BLM) in SLE patients in clinical practice and to examine its efficacy in terms of standardized outcomes, drug survival, as well as patient and safety profiles. METHODS: A longitudinal retrospective multicentre cohort including SLE patients treated with BLM at 18 Spanish centers. Data was collected upon initiation of BLM, at 6 and 12 months after initiation, and at the last recorded visit...
March 15, 2024: Rheumatology
#89
JOURNAL ARTICLE
Ai Kuzumi, Ayumi Yoshizaki, Ruriko Kawanabe, Shinichi Sato
No abstract text is available yet for this article.
March 14, 2024: Rheumatology
#90
JOURNAL ARTICLE
Amy Fuller, Jennie Hancox, Hywel C Williams, Tim Card, Maarten W Taal, Guruprasad P Aithal, Christopher P Fox, Christian D Mallen, James R Maxwell, Sarah Bingham, Kavita Vedhara, Abhishek Abhishek
OBJECTIVE: To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). METHODS: Adults (≥18 years) taking immune-suppressing treatment(s) for at-least six months, and healthcare professionals (HCPs) with experience of either prescribing and/or monitoring immune-suppressing drugs were invited to participate in a single, remote, one-to-one, semi-structured interview...
March 14, 2024: Rheumatology
#91
JOURNAL ARTICLE
Veronica Venturelli, Beatrice Maranini, Ibrahim Tohidi-Esfahani, David A Isenberg, Hannah Cohen, Maria Efthymiou
APS is an autoimmune disorder with life-threatening complications that, despite therapeutic advantages, remains associated with thrombotic recurrences and treatment failure. The role of complement activation in APS pathogenesis is increasingly recognised, specifically in obstetric APS. However, its exact role in thrombotic APS and on the severity of the disease is not yet fully elucidated. Further mechanistic studies are needed to delineate the role of complement activation in the various APS clinical manifestations with aim to identify novel markers of disease severity, together with clinical trials to evaluate the efficacy of complement inhibition in APS...
March 14, 2024: Rheumatology
#92
JOURNAL ARTICLE
Georgina Nakafero, Matthew J Grainge, Tim Card, Christian D Mallen, Jonathan S Nguyen Van-Tam, Abhishek Abhishek
OBJECTIVE: The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association between vaccination and IMID flare. METHODS: Adults with IMIDs diagnosed on or before 01/09/2018, prescribed steroid-sparing drugs within the last 12 months and contributing data to the Clinical Practice Research Datalink Gold were included...
March 13, 2024: Rheumatology
#93
JOURNAL ARTICLE
Jina Yeo, Ju Yeon Kim, Jin Kyun Park, Kichul Shin, Eun Young Lee, Tae-Hwan Kim, Jun Won Park
OBJECTIVES: To develop a model for predicting flares after tapering the dose of tumour necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). METHODS: Data were obtained from the Korean College of Rheumatology Biologics and Targeted Therapy Registry. In total, 526 patients who received the standard-dose TNFi for at least 1 year and tapered their dose were included in the derivation cohort. The main outcome was a flare occurrence defined as an Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) score of ≥ 2...
March 13, 2024: Rheumatology
#94
JOURNAL ARTICLE
Ngoc V Nguyen, Elisabet Svenungsson, Annica Dominicus, Maria Altman, Karin Hellgren, Julia F Simard, Elizabeth V Arkema
OBJECTIVES: To assess the infant risk of major congenital malformations (MCM) associated with first-trimester exposure to hydroxychloroquine (HCQ) among mothers with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). METHODS: This population-based cohort study utilised Swedish nationwide registers and included all singleton births (2006-2021) among individuals with prevalent SLE or RA in Sweden. The exposure was filling ≥1 HCQ prescription during the first trimester...
March 13, 2024: Rheumatology
#95
JOURNAL ARTICLE
Aravinthan Loganathan, Latika Gupta, Alex Rudge, Hui Lu, Elizabeth Bowler, Fionnuala McMorrow, R Naveen, Anamika K Anuja, Vikas Agarwal, Neil McHugh, Sarah Tansley
OBJECTIVES: Myositis-specific and associated autoantibodies are important biomarkers in routine clinical use. We assessed local testing performance for myositis autoantibodies by comparing line immunoassay (LIA) to protein radio-immunoprecipitation and identifying clinical characteristics associated with each myositis autoantibody in the MyoCite cohort. METHODS: Serum samples from patients within the MyoCite cohort, a well-characterised retro-prospective dataset of adult and juvenile idiopathic inflammatory myopathy (IIM) patients in Lucknow, India (2017-2020), underwent LIA at Sanjay Gandhi Postgraduate Institute of Medical Science (SGPGIMS), Lucknow...
March 13, 2024: Rheumatology
#96
JOURNAL ARTICLE
Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
OBJECTIVES: To stratify patients with mixed connective tissue disease (MCTD) based on their immunophenotype. METHODS: We analyzed the immunophenotype and transcriptome of 24 immune cell subsets from patients with MCTD, systemic lupus erythematosus (SLE), idiopathic inflammatory myopathy (IIM), and systemic sclerosis (SSc) from our functional genome database, ImmuNexUT (https://www.immunexut.org/). MCTD patients were stratified by employing machine learning models including Random Forest, trained by immunophenotyping data from SLE, IIM, and SSc patients...
March 13, 2024: Rheumatology
#97
JOURNAL ARTICLE
Durga Prasanna Misra, Upendra Rathore, Swapnil Jagtap, Kritika Singh
No abstract text is available yet for this article.
March 13, 2024: Rheumatology
#98
JOURNAL ARTICLE
Comment on: Switching from prednisolone to dexamethasone in difficult-to-treat rheumatoid arthritis.
Takao Nagashima, Hiroki Yabe, Tsuyoshi Kobashigawa
No abstract text is available yet for this article.
March 12, 2024: Rheumatology
#99
JOURNAL ARTICLE
Kathleen Morrisroe, Dylan Hansen, Wendy Stevens, Laura Ross, Joanne Sahhar, Gene-Siew Ngian, Catherine Hill, Lauren Host, Jennifer Walker, Susanna Proudman, Mandana Nikpour
OBJECTIVE: To identify those with concurrent pulmonary hypertension (PH) and interstitial lung disease (ILD) in systemic sclerosis (SSc) and determine their disease severity, therapeutic approach, and survival. METHODS: Consecutive SSc patients enrolled in the Australian Scleroderma Cohort Study (ASCS) who were diagnosed on right heart catherisation with pulmonary hypertension were included. Logistic regression was used to determine the associations of ILD with PH hemodynamic parameters and therapeutic approach...
March 12, 2024: Rheumatology
#100
JOURNAL ARTICLE
Tiffany Dal Santo, Danielle B Rice, Marie-Eve Carrier, Gabrielle Virgili-Gervais, Brooke Levis, Linda Kwakkenbos, Meira Golberg, Susan J Bartlett, Amy Gietzen, Karen Gottesman, Geneviève Guillot, Marie Hudson, Laura K Hummers, Vanessa L Malcarne, Maureen D Mayes, Luc Mouthon, Michelle Richard, Maureen Sauvé, Robyn K Wojeck, Marie-Claude Geoffroy, Andrea Benedetti, Brett D Thombs
OBJECTIVES: To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors. METHODS: Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables...
March 12, 2024: Rheumatology
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