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Lancet Infectious Diseases

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https://read.qxmd.com/read/30885591/use-of-ribaxamase-syn-004-a-%C3%AE-lactamase-to-prevent-clostridium-difficile-infection-in-%C3%AE-lactam-treated-patients-a-double-blind-phase-2b-randomised-placebo-controlled-trial
#1
John F Kokai-Kun, Tracey Roberts, Olivia Coughlin, Chenxiong Le, Heidi Whalen, Ralph Stevenson, Vincent J Wacher, Joseph Sliman
BACKGROUND: Infections with Clostridium difficile are a health threat, yet no products are currently licensed for prevention of primary C difficile infections. Intravenous β-lactam antibiotics are considered to confer a high risk of C difficile infection because of their biliary excretion into the gastrointestinal tract and disruption of the gut microbiome. ribaxamase (SYN-004) is an orally administered β-lactamase that was designed to be given with intravenous β-lactam antibiotics to degrade excess antibiotics in the upper gastrointestinal tract before they disrupt the gut microbiome and lead to C difficile infection...
March 15, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30885590/a-solution-to-the-problem-of-antibiotic-induced-collateral-damage-to-the-gut-microbiome
#2
Simon D Goldenberg
No abstract text is available yet for this article.
March 15, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30885589/human-cyclosporiasis
#3
REVIEW
Annunziata Giangaspero, Robin B Gasser
Cyclospora species are socioeconomically important protistan pathogens. Cyclospora cayetanensis is usually transmitted via food or water to a human host via the faecal-oral route and can cause the gastrointestinal disease cyclosporiasis, which can be complicated by extra-intestinal disorders, particularly in immune-compromised people. Although more than 2 million children die each year from diarrhoeal diseases worldwide, it is not known to what extent cyclosporiasis is involved. Few epidemiological data are available on Cyclospora as a water-borne and food-borne pathogen in both underprivileged communities and developed countries...
March 15, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30858015/correction-to-lancet-infect-dis-2019-published-online-feb-27-https-doi-org-10-1016-s1473-3099-18-30718-7
#4
(no author information available yet)
No abstract text is available yet for this article.
March 8, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30858014/an-environmental-cleaning-bundle-and-health-care-associated-infections-in-hospitals-reach-a-multicentre-randomised-trial
#5
Brett G Mitchell, Lisa Hall, Nicole White, Adrian G Barnett, Kate Halton, David L Paterson, Thomas V Riley, Anne Gardner, Katie Page, Alison Farrington, Christian A Gericke, Nicholas Graves
BACKGROUND: The hospital environment is a reservoir for the transmission of microorganisms. The effect of improved cleaning on patient-centred outcomes remains unclear. We aimed to evaluate the effectiveness of an environmental cleaning bundle to reduce health care-associated infections in hospitals. METHODS: The REACH study was a pragmatic, multicentre, randomised trial done in 11 acute care hospitals in Australia. Eligible hospitals had an intensive care unit, were classified by the National Health Performance Authority as a major hospital (public hospitals) or having more than 200 inpatient beds (private hospitals), and had a health-care-associated infection surveillance programme...
March 8, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30858013/can-cleaning-reach-further-in-reducing-hospital-infections
#6
Jonathan A Otter
No abstract text is available yet for this article.
March 8, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30853252/assessing-a-drug-for-an-eradicated-human-disease-us-food-and-drug-administration-review-of-tecovirimat-for-the-treatment-of-smallpox
#7
REVIEW
Kirk M Chan-Tack, Patrick R Harrington, Su-Young Choi, Laine Myers, Julian O'Rear, Shirley Seo, David McMillan, Hanan Ghantous, Debra Birnkrant, Adam I Sherwat
The development and ultimate approval of tecovirimat for the antiviral treatment of smallpox, a disease that has been eradicated from the world for nearly 40 years, required a unique regulatory approach based on the US Food and Drug Administration's Animal Rule. We summarise the regulatory pathway and describe the challenges involved.
March 7, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30853251/opat-for-avoidance-of-hospitalisation-in-children
#8
Nathan M Krah, Adam L Hersh
No abstract text is available yet for this article.
March 7, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30853250/efficacy-and-safety-of-intravenous-ceftriaxone-at-home-versus-intravenous-flucloxacillin-in-hospital-for-children-with-cellulitis-choice-a-single-centre-open-label-randomised-controlled-non-inferiority-trial
#9
Laila F Ibrahim, Sandy M Hopper, Francesca Orsini, Andrew J Daley, Franz E Babl, Penelope A Bryant
BACKGROUND: Outpatient parenteral antimicrobial therapy in children is common despite no evidence of its efficacy or safety from clinical trials. We aimed to compare the efficacy and safety of intravenous antibiotic therapy at home with that of standard treatment in hospital for children with moderate to severe cellulitis. METHODS: The Cellulitis at Home or Inpatient in Children from the Emergency Department (CHOICE) trial was a randomised, controlled, non-inferiority trial in children aged 6 months to 18 years who presented to the emergency department at The Royal Children's Hospital (Melbourne, VIC, Australia) with uncomplicated moderate to severe cellulitis...
March 7, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30852076/correction-to-lancet-infect-dis-2019-19-e77-88
#10
(no author information available yet)
No abstract text is available yet for this article.
March 6, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30846278/how-fluoroquinolones-poison-the-neighbourhood
#11
Cornelis H van Werkhoven, Martin Bootsma, Marc Bonten
No abstract text is available yet for this article.
March 4, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30846277/association-between-urinary-community-acquired-fluoroquinolone-resistant-escherichia-coli-and-neighbourhood-antibiotic-consumption-a-population-based-case-control-study
#12
Marcelo Low, Ami Neuberger, Thomas M Hooton, Manfred S Green, Raul Raz, Ran D Balicer, Ronit Almog
BACKGROUND: It is unknown whether increased use of antibiotics in a community increases the risk of acquiring antibiotic resistance by individuals living in that community, regardless of prior individual antibiotic consumption and other risk factors for antibiotic resistance. METHODS: We used a hierarchical multivariate logistic regression approach to evaluate the association between neighbourhood fluoroquinolone consumption and individual risk of colonisation or infection of the urinary tract with fluoroquinolone-resistant Escherichia coli...
March 4, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30833161/will-dual-japanese-encephalitis-and-measles-rubella-vaccination-hinder-measles-and-rubella-eradication
#13
Katie L Flanagan
No abstract text is available yet for this article.
March 1, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30833160/immunogenicity-and-safety-of-measles-rubella-vaccine-co-administered-with-attenuated-japanese-encephalitis-sa-14-14-2-vaccine-in-infants-aged-8-months-in-china-a-non-inferiority-randomised-controlled-trial
#14
Yan Li, Susan Y Chu, Chenyan Yue, Kathleen Wannemuehler, Shuyun Xie, Fubin Zhang, Yamin Wang, Yuxi Zhang, Rui Ma, Yumin Li, Zhiping Zuo, Lance Rodewald, Qiyou Xiao, Zijian Feng, Huaqing Wang, Zhijie An
BACKGROUND: In China, measles-rubella vaccine and live attenuated SA 14-14-2 Japanese encephalitis vaccine (LJEV) are recommended for simultaneous administration at 8 months of age, which is the youngest recommended age for these vaccines worldwide. We aimed to assess the effect of the co-administration of these vaccines at 8 months of age on the immunogenicity of measles-rubella vaccine. METHODS: We did a multicentre, open-label, non-inferiority, two-group randomised controlled trial in eight counties or districts in China...
March 1, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30827809/antibiotic-prescription-in-paediatric-emergency-departments-fear-and-reason
#15
Elise Launay, Christèle Gras Le Guen
No abstract text is available yet for this article.
February 28, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30827808/antibiotic-prescription-for-febrile-children-in-european-emergency-departments-a-cross-sectional-observational-study
#16
Josephine van de Maat, Elles van de Voort, Santiago Mintegi, Alain Gervaix, Daan Nieboer, Henriette Moll, Rianne Oostenbrink
BACKGROUND: Prevalence of serious bacterial infections in children in countries in western Europe and the USA is low. Antibiotic stewardship aims at a more rational use of antibiotics but information on the frequency of antibiotic prescription to children in emergency departments is scarce. We aimed to quantify and explain variability in antibiotic prescription in children attending European paediatric emergency departments. METHODS: We did a cross-sectional, observational study of children aged between 1 month and 16 years who presented with fever to one of 28 European emergency departments on one random sampling day per month between Nov 1, 2014, and Feb 28, 2016...
February 28, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30826191/endemic-zika-virus-transmission-implications-for-travellers
#17
Margaret A Honein, Martin S Cetron, Dana Meaney-Delman
No abstract text is available yet for this article.
February 27, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30826190/correction-to-lancet-infect-dis-2019-published-online-feb-21-https-doi-org-10-1016-s1473-3099-18-30757-6
#18
(no author information available yet)
No abstract text is available yet for this article.
February 27, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30826189/long-term-circulation-of-zika-virus-in-thailand-an-observational-study
#19
Kriangsak Ruchusatsawat, Pattara Wongjaroen, Arisara Posanacharoen, Isabel Rodriguez-Barraquer, Somchai Sangkitporn, Derek A T Cummings, Henrik Salje
BACKGROUND: Little is known about the historical and current risk of Zika virus infection in southeast Asia, where the mosquito vector is widespread and other arboviruses circulate endemically. Centralised Zika virus surveillance began in Thailand in January, 2016. We assessed the long-term circulation of Zika virus in Thailand. METHODS: In this observational study, we analysed data from individuals with suspected Zika virus infection who presented at hospitals throughout the country and had biological samples (serum, plasma, or urine) tested for confirmation with PCR at the National Institute of Health laboratories in Bangkok...
February 27, 2019: Lancet Infectious Diseases
https://read.qxmd.com/read/30799253/the-genesis-of-the-ebola-virus-outbreak-in-west-africa
#20
Eugene T Richardson, Mosoka P Fallah
No abstract text is available yet for this article.
February 21, 2019: Lancet Infectious Diseases
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