journal
https://read.qxmd.com/read/32986997/human-t-cell-lymphotropic-virus-type-1-a-lifelong-persistent-infection-yet-never-truly-silent
#1
REVIEW
Ashley Hirons, Georges Khoury, Damian F J Purcell
Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key communities, such as Indigenous Australians living in remote areas, greater than 45% of people are infected. Despite HTLV-1 causing serious malignancy and myelopathic paraparesis, and a significant association with a range of inflammatory comorbidities and secondary infections that shorten lifespan, few biomedical interventions are available. HTLV-1 starkly contrasts with other blood-borne sexually transmitted viral infections, such as, HIV, hepatitis B virus, and hepatitis C virus, with no antiviral treatments that reduce virus-infected cells, no rapid diagnostics or biomarker assays suitable for use in remote settings, and no effective vaccine...
September 25, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32986996/the-direct-effect-of-pneumococcal-conjugate-vaccines-on-invasive-pneumococcal-disease-in-children-in-the-latin-american-and-caribbean-region-sireva-2006-17-a-multicentre-retrospective-observational-study
#2
Clara Inés Agudelo, Carlos Castañeda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echániz-Aviles, Samanta Cristine Grassi Almeida, María Noemí Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcón, Pamela Araya, Carolina Duarte, Jacqueline Sánchez, Mirna Novas, Gilda Toraño-Peraza, Misladys Rodríguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela García-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucía Andrade, José Luis Di Fabio, Elizabeth Castañeda
BACKGROUND: Streptococcus pneumoniae isolated from patients with invasive pneumococcal disease has been subjected to laboratory-based surveillance in Latin American and Caribbean countries since 1993. Invasive pneumococcal diseases remain a major cause of death and disability worldwide, particularly in children. We therefore aimed to assess the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years before and after PCV introduction...
September 25, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32986995/direct-effects-of-pneumococcal-conjugate-vaccines-among-children-in-latin-america-and-the-caribbean
#3
Cynthia G Whitney, Cristiana M Toscano
No abstract text is available yet for this article.
September 25, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32979932/a-blood-based-host-gene-expression-assay-for-early-detection-of-respiratory-viral-infection-an-index-cluster-prospective-cohort-study
#4
Micah T McClain, Florica J Constantine, Bradly P Nicholson, Marshall Nichols, Thomas W Burke, Ricardo Henao, Daphne C Jones, Lori L Hudson, L Brett Jaggers, Timothy Veldman, Anna Mazur, Lawrence P Park, Sunil Suchindran, Ephraim L Tsalik, Geoffrey S Ginsburg, Christopher W Woods
BACKGROUND: Early and accurate identification of individuals with viral infections is crucial for clinical management and public health interventions. We aimed to assess the ability of transcriptomic biomarkers to identify naturally acquired respiratory viral infection before typical symptoms are present. METHODS: In this index-cluster study, we prospectively recruited a cohort of undergraduate students (aged 18-25 years) at Duke University (Durham, NC, USA) over a period of 5 academic years...
September 24, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32979931/recognising-the-asymptomatic-enemy
#5
Miriam Cebey-López, Antonio Salas
No abstract text is available yet for this article.
September 24, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32979318/performance-characteristics-of-five-immunoassays-for-sars-cov-2-a-head-to-head-benchmark-comparison
#6
(no author information available yet)
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in 2020. Testing is crucial for mitigating public health and economic effects. Serology is considered key to population-level surveillance and potentially individual-level risk assessment. However, immunoassay performance has not been compared on large, identical sample sets. We aimed to investigate the performance of four high-throughput commercial SARS-CoV-2 antibody immunoassays and a novel 384-well ELISA...
September 23, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32979317/the-complexities-of-sars-cov-2-serology
#7
Catherine F Houlihan, Rupert Beale
No abstract text is available yet for this article.
September 23, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32971007/covid-19-in-malaria-endemic-regions-potential-consequences-for-malaria-intervention-coverage-morbidity-and-mortality
#8
Miranda I Teboh-Ewungkem, Gideon A Ngwa
No abstract text is available yet for this article.
September 21, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32971006/indirect-effects-of-the-covid-19-pandemic-on-malaria-intervention-coverage-morbidity-and-mortality-in-africa-a-geospatial-modelling-analysis
#9
Daniel J Weiss, Amelia Bertozzi-Villa, Susan F Rumisha, Punam Amratia, Rohan Arambepola, Katherine E Battle, Ewan Cameron, Elisabeth Chestnutt, Harry S Gibson, Joseph Harris, Suzanne Keddie, Justin J Millar, Jennifer Rozier, Tasmin L Symons, Camilo Vargas-Ruiz, Simon I Hay, David L Smith, Pedro L Alonso, Abdisalan M Noor, Samir Bhatt, Peter W Gething
BACKGROUND: Substantial progress has been made in reducing the burden of malaria in Africa since 2000, but those gains could be jeopardised if the COVID-19 pandemic affects the availability of key malaria control interventions. The aim of this study was to evaluate plausible effects on malaria incidence and mortality under different levels of disruption to malaria control. METHODS: Using an established set of spatiotemporal Bayesian geostatistical models, we generated geospatial estimates across malaria-endemic African countries of the clinical case incidence and mortality of malaria, incorporating an updated database of parasite rate surveys, insecticide-treated net (ITN) coverage, and effective treatment rates...
September 21, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32949500/intravesical-bacteriophages-for-treating-urinary-tract-infections-in-patients-undergoing-transurethral-resection-of-the-prostate-a-randomised-placebo-controlled-double-blind-clinical-trial
#10
Lorenz Leitner, Aleksandre Ujmajuridze, Nina Chanishvili, Marina Goderdzishvili, Irina Chkonia, Sophia Rigvava, Archil Chkhotua, Giorgi Changashvili, Shawna McCallin, Marc P Schneider, Martina D Liechti, Ulrich Mehnert, Lucas M Bachmann, Wilbert Sybesma, Thomas M Kessler
BACKGROUND: Urinary tract infections (UTIs) are among the most prevalent microbial diseases and their financial burden on society is substantial. In the context of increasing antibiotic resistance, finding alternative treatments for UTIs is a top priority. We aimed to determine whether intravesical bacteriophage therapy with a commercial bacteriophage cocktail is effective in treating UTI. METHODS: We did a randomised, placebo-controlled, clinical trial, at the Alexander Tsulukidze National Centre of Urology, Tbilisi, Georgia...
September 16, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32949499/bacteriophages-it-s-a-medicine-jim-but-not-as-we-know-it
#11
Jean-Paul Pirnay, Elizabeth Kutter
No abstract text is available yet for this article.
September 16, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32946837/defending-against-a-difficult-clostridioides-with-a-vaccine
#12
Sahil Khanna
No abstract text is available yet for this article.
September 15, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32946836/safety-immunogenicity-and-efficacy-of-a-clostridioides-difficile-toxoid-vaccine-candidate-a-phase-3-multicentre-observer-blind-randomised-controlled-trial
#13
Guy de Bruyn, David L Gordon, Theodore Steiner, Paul Tambyah, Catherine Cosgrove, Mark Martens, Ehab Bassily, Eng-Soon Chan, Dhaval Patel, Josh Chen, Julian Torre-Cisneros, Carlos Fernando De Magalhães Francesconi, Richard Gesser, Robert Jeanfreau, Odile Launay, Thelma Laot, Rayo Morfin-Otero, Ernesto Oviedo-Orta, Yoon Soo Park, Franco M Piazza, Christine Rehm, Enrique Rivas, Steve Self, Sanjay Gurunathan
BACKGROUND: In the absence of a licensed vaccine, Clostridioides (formerly Clostridium) difficile infection represents a substantial health burden. The aim of this study was to evaluate the efficacy, immunogenicity, and safety of a toxoid vaccine candidate. METHODS: We did a phase 3 multicentre, observer-blind, randomised, controlled trial at 326 hospitals, clinics, and clinical research centres in 27 countries in the USA, Canada, Latin America, Europe, and the Asia-Pacific region...
September 15, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32946835/associations-between-phone-mobility-data-and-covid-19-cases
#14
LETTER
Oliver Gatalo, Katie Tseng, Alisa Hamilton, Gary Lin, Eili Klein
No abstract text is available yet for this article.
September 15, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32941786/intention-to-vaccinate-against-covid-19-in-australia
#15
LETTER
Anthea Rhodes, Monsurul Hoq, Mary-Anne Measey, Margie Danchin
No abstract text is available yet for this article.
September 14, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32926836/sars-cov-2-transmission-via-speech-generated-respiratory-droplets
#16
LETTER
Adriaan Bax, Christina E Bax, Valentyn Stadnytskyi, Philip Anfinrud
No abstract text is available yet for this article.
September 11, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32926835/correction-to-lancet-infect-dis-2020-published-online-aug-25-https-doi-org-10-1016-s1473-3099-20-30289-9
#17
(no author information available yet)
No abstract text is available yet for this article.
September 11, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32926834/safety-and-immunogenicity-of-co-administered-hookworm-vaccine-candidates-na-gst-1-and-na-apr-1-in-gabonese-adults-a-randomised-controlled-double-blind-phase-1-dose-escalation-trial
#18
Ayola A Adegnika, Sophia G de Vries, Frejus J Zinsou, Yabo J Honkepehedji, Jean-Claude Dejon Agobé, Kafui G Vodonou, Rodrigue Bikangui, Aurore Bouyoukou Hounkpatin, Emmanuel B Bache, Marguerite Massinga Loembe, Remko van Leeuwen, Marjan Molemans, Peter G Kremsner, Maria Yazdanbakhsh, Peter J Hotez, Maria Elena Bottazzi, Guangzhao Li, Jeffrey M Bethony, David J Diemert, Martin P Grobusch
BACKGROUND: Hookworms cause substantial morbidity in children and women of reproductive age. The control strategy of mass drug administration is suboptimal, hence the need for a vaccine. Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are involved in the digestion and detoxification of haemoglobin in the hookworm digestive tract. In animal models, vaccination against these antigens resulted in protection from challenge infection...
September 11, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32926833/correction-to-lancet-infect-dis-2020-published-online-aug-25-https-doi-org-10-1016-s1473-3099-20-30577-6
#19
(no author information available yet)
No abstract text is available yet for this article.
September 11, 2020: Lancet Infectious Diseases
https://read.qxmd.com/read/32919520/curing-covid-19
#20
EDITORIAL
The Lancet Infectious Diseases
No abstract text is available yet for this article.
September 10, 2020: Lancet Infectious Diseases
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