journal
https://read.qxmd.com/read/33865461/laboratory-informatics-capacity-for-effective-antimicrobial-resistance-surveillance-in-resource-limited-settings
#21
REVIEW
Paul Turner, Priscilla Rupali, Japheth A Opintan, Walter Jaoko, Nicholas A Feasey, Sharon J Peacock, Elizabeth A Ashley
Antimicrobial resistance (AMR) is a major threat to human health globally. Surveillance is a key activity to determine AMR burden, impacts, and trends and to monitor effects of interventions. Surveillance systems require efficient capture and onward sharing of high-quality laboratory data. Substantial investment is being made to improve laboratory capacity, particularly in low-income and middle-income countries (LMICs) with high disease burdens. However, building capacity for effective laboratory data management remains an under-resourced area, which, unless addressed, will limit progress towards comprehensive AMR surveillance in LMICs...
April 15, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33864804/lowering-sars-cov-2-viral-load-might-affect-transmission-but-not-disease-severity-in-secondary-cases-authors-reply
#22
LETTER
Matthew A Spinelli, George Rutherford, Monica Gandhi
No abstract text is available yet for this article.
April 14, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33864803/lowering-sars-cov-2-viral-load-might-affect-transmission-but-not-disease-severity-in-secondary-cases
#23
LETTER
Mattia Trunfio, Andrea Calcagno, Stefano Bonora, Giovanni Di Perri
No abstract text is available yet for this article.
April 14, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33864802/has-artemisinin-resistance-emerged-in-africa
#24
Philip J Rosenthal
No abstract text is available yet for this article.
April 14, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33864801/association-of-plasmodium-falciparum-kelch13-r561h-genotypes-with-delayed-parasite-clearance-in-rwanda-an-open-label-single-arm-multicentre-therapeutic-efficacy-study
#25
Aline Uwimana, Noella Umulisa, Meera Venkatesan, Samaly S Svigel, Zhiyong Zhou, Tharcisse Munyaneza, Rafiki M Habimana, Anicet Rucogoza, Leah F Moriarty, Ryan Sandford, Emily Piercefield, Ira Goldman, Bryan Ezema, Eldin Talundzic, M Andreína Pacheco, Ananias A Escalante, Daniel Ngamije, Jean-Louis N Mangala, Michee Kabera, Kaendi Munguti, Monique Murindahabi, William Brieger, Clarisse Musanabaganwa, Leon Mutesa, Venkatachalam Udhayakumar, Aimable Mbituyumuremyi, Eric S Halsey, Naomi W Lucchi
BACKGROUND: Partial artemisinin resistance is suspected if delayed parasite clearance (ie, persistence of parasitaemia on day 3 after treatment initiation) is observed. Validated markers of artemisinin partial resistance in southeast Asia, Plasmodium falciparum kelch13 (Pfkelch13) R561H and P574L, have been reported in Rwanda but no association with parasite clearance has been observed. We aimed to establish the efficacy of artemether-lumefantrine and genetic characterisation of Pfkelch13 alleles and their association with treatment outcomes...
April 14, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33861968/sars-cov-2-incidence-and-vaccine-escape
#26
LETTER
Robin N Thompson, Edward M Hill, Julia R Gog
No abstract text is available yet for this article.
April 13, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33857408/beyond-covid-19-will-self-sampling-and-testing-become-the-norm
#27
Yap Boum, Sara Eyangoh, Marie-Claire Okomo
No abstract text is available yet for this article.
April 12, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33857407/lack-of-detail-in-population-level-data-impedes-analysis-of-sars-cov-2-variants-of-concern-and-clinical-outcomes
#28
Sean Wei Xiang Ong, Barnaby Edward Young, David Chien Lye
No abstract text is available yet for this article.
April 12, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33857406/genomic-characteristics-and-clinical-effect-of-the-emergent-sars-cov-2-b-1-1-7-lineage-in-london-uk-a-whole-genome-sequencing-and-hospital-based-cohort-study
#29
Dan Frampton, Tommy Rampling, Aidan Cross, Heather Bailey, Judith Heaney, Matthew Byott, Rebecca Scott, Rebecca Sconza, Joseph Price, Marios Margaritis, Malin Bergstrom, Moira J Spyer, Patricia B Miralhes, Paul Grant, Stuart Kirk, Chris Valerio, Zaheer Mangera, Thaventhran Prabhahar, Jeronimo Moreno-Cuesta, Nish Arulkumaran, Mervyn Singer, Gee Yen Shin, Emilie Sanchez, Stavroula M Paraskevopoulou, Deenan Pillay, Rachel A McKendry, Mariyam Mirfenderesky, Catherine F Houlihan, Eleni Nastouli
BACKGROUND: Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass vaccination campaigns and use of monoclonal antibodies. We aimed to describe the emergence of the B.1.1.7 variant of concern (VOC), including virological characteristics and clinical severity in contemporaneous patients with and without the variant. METHODS: In this cohort study, samples positive for SARS-CoV-2 on PCR that were collected from Nov 9, 2020, for patients acutely admitted to one of two hospitals on or before Dec 20, 2020, in London, UK, were sequenced and analysed for the presence of VOC-defining mutations...
April 12, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33857405/diagnostic-performance-of-different-sampling-approaches-for-sars-cov-2-rt-pcr-testing-a-systematic-review-and-meta-analysis
#30
Nicole Ngai Yung Tsang, Hau Chi So, Ka Yan Ng, Benjamin J Cowling, Gabriel M Leung, Dennis Kai Ming Ip
BACKGROUND: The comparative performance of different clinical sampling methods for diagnosis of SARS-CoV-2 infection by RT-PCR among populations with suspected infection remains unclear. This meta-analysis aims to systematically compare the diagnostic performance of different clinical specimen collection methods. METHODS: In this systematic review and meta-analysis, we systematically searched PubMed, Embase, MEDLINE, Web of Science, medRxiv, bioRxiv, SSRN, and Research Square from Jan 1, 2000, to Nov 16, 2020...
April 12, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33844977/-in-an-ocean-of-ashes-islands-of-order-who-s-sars-cov-2-origin-report
#31
EDITORIAL
The Lancet Infectious Diseases
No abstract text is available yet for this article.
April 9, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33836161/new-regimens-of-benznidazole-monotherapy-and-in-combination-with-fosravuconazole-for-treatment-of-chagas-disease-bendita-a-phase-2-double-blind-randomised-trial
#32
Faustino Torrico, Joaquim Gascón, Fabiana Barreira, Bethania Blum, Igor C Almeida, Cristina Alonso-Vega, Tayná Barboza, Graeme Bilbe, Erika Correia, Wilson Garcia, Lourdes Ortiz, Rudy Parrado, Juan Carlos Ramirez, Isabela Ribeiro, Nathalie Strub-Wourgaft, Michel Vaillant, Sergio Sosa-Estani
BACKGROUND: Current treatment for Chagas disease with the only available drugs, benznidazole or nifurtimox, has substantial limitations, including long treatment duration and safety and tolerability concerns. We aimed to evaluate the efficacy and safety of new benznidazole monotherapy regimens and combinations with fosravuconazole, in the treatment of Chagas disease. METHODS: We did a double-blind, double-dummy, phase 2, multicentre, randomised trial in three outpatient units in Bolivia...
April 6, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33836160/parasitological-cure-in-children-infected-with-trypanosoma-cruzi
#33
Leonardo M Leony, Fred L N Santos
No abstract text is available yet for this article.
April 6, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33836159/new-treatment-regimens-for-chagas-disease-light-at-the-end-of-the-tunnel
#34
Carlos A Morillo, Luis E Echeverria
No abstract text is available yet for this article.
April 6, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33836158/correction-to-lancet-infect-dis-2021-published-onlinefeb-1-https-doi-org-10-1016-s1473-3099-20-30738-6
#35
(no author information available yet)
No abstract text is available yet for this article.
April 6, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33836157/prediction-of-parasitological-cure-in-children-infected-with-trypanosoma-cruzi-using-a-novel-multiplex-serological-approach-an-observational-retrospective-cohort-study
#36
Laura Jurado Medina, Emeric Chassaing, Griselda Ballering, Nicolas Gonzalez, Lola Marqué, Peter Liehl, Hans Pottel, Jasper de Boer, Eric Chatelain, Maan Zrein, Jaime Altcheh
BACKGROUND: Assessment of therapeutic response with standard serological diagnostic assays in patients with chronic Chagas disease is a major challenge due to the long persistence of parasite-specific antibodies. The current consensus for parasitological cure is to monitor conversion from positive to negative Trypanosoma cruzi serology (seroreversion). However, because of robust humoral immune response, seroreversion by standard serological tests can take years to decades. Developing novel tests of parasitological cure or surrogates is thus a priority in the Chagas disease field...
April 6, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33811817/prioritising-covid-19-vaccination-in-changing-social-and-epidemiological-landscapes-a-mathematical-modelling-study
#37
Peter C Jentsch, Madhur Anand, Chris T Bauch
BACKGROUND: During the COVID-19 pandemic, authorities must decide which groups to prioritise for vaccination in a shifting social-epidemiological landscape in which the success of large-scale non-pharmaceutical interventions requires broad social acceptance. We aimed to compare projected COVID-19 mortality under four different strategies for the prioritisation of SARS-CoV-2 vaccines. METHODS: We developed a coupled social-epidemiological model of SARS-CoV-2 transmission in which social and epidemiological dynamics interact with one another...
March 31, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33811816/correction-to-lancet-infect-dis-2020-published-online-march-25-https-doi-org-10-1016-s1473-3099-21-00151-1
#38
(no author information available yet)
No abstract text is available yet for this article.
March 31, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33811815/the-interplay-between-covid-19-restrictions-and-vaccination
#39
Chad R Wells, Alison P Galvani
No abstract text is available yet for this article.
March 31, 2021: Lancet Infectious Diseases
https://read.qxmd.com/read/33798488/moxidectin-an-ally-to-ivermectin-for-treating-strongyloides-stercoralis
#40
Zeno Bisoffi, Dora Buonfrate
No abstract text is available yet for this article.
March 30, 2021: Lancet Infectious Diseases
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