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Journal of Clinical Endocrinology and Metabolism

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https://read.qxmd.com/read/31298706/68ga-exendin-4-pet-ct-detects-insulinomas-in-patients-with-endogenous-hyperinsulinemic-hypoglycemia-in-men-1
#1
Kwadwo Antwi, Guillaume Nicolas, Melpomeni Fani, Tobias Heye, Francois Pattou, Ashley Grossman, Philippe Chanson, Jean Claude Reubi, Perren Aurrel, Beat Gloor, Deborah R Vogt, Damian Wild, Emanuel Christ
CONTEXT: Surgical intervention is advised in patients with multiple endocrine neoplasia type-1 (MEN-1) with non-functioning pancreatic neuroendocrine tumors (PanNET) and a size ≥20mm. Functioning PanNET such as patients with endogenous hyperinsulinemic hypoglycemia (EHH) due to (one or multiple) insulinoma(s) should be treated surgically independent of size. Preoperative localization of insulinomas is critical for surgery. OBJECTIVE: To evaluate feasibility and sensitivity of 68Ga-DOTA-exendin-4 PET/CT in the detection of clinical-relevant lesions in MEN-1 patients with EHH in combination with MRI...
July 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31298704/oxidative-stress-in-response-to-saturated-fat-ingestion-is-linked-to-insulin-resistance-and-hyperandrogenism-in-pcos
#2
Frank González, Robert V Considine, Ola A Abdelhadi, Anthony J Acton
CONTEXT: Oxidative stress and insulin resistance are often present in Polycystic Ovary Syndrome (PCOS). OBJECTIVE: We determined the effect of saturated fat ingestion on leukocytic reactive oxygen species (ROS) generation and p47phox expression, and circulating thiobarituric substances (TBARS) in women with PCOS. DESIGN: Cross-sectional study. SETTING: Academic medical center. PATIENTS: Twenty reproductive-age women with PCOS (10 lean, 10 obese) and 19 ovulatory controls (10 lean, 9 obese)...
July 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31298702/response-to-letter-to-the-editor-two-thirds-of-all-fractures-are-not-attributable-to-osteoporosis-and-advancing-age-implication-for-fracture-prevention
#3
Ha T Mai, Thach S Tran, Thao P Ho-Le, Jacqueline R Center, John A Eisman, Tuan V Nguyen
No abstract text is available yet for this article.
July 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31298699/letter-to-the-editor-two-thirds-of-all-fractures-are-not-attributable-to-osteoporosis-and-advancing-age-implication-for-fracture-prevention
#4
Zhangxin Wen, Rong Chen, Hong Liu
No abstract text is available yet for this article.
July 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31294795/hydroxylated-long-chain-acylcarnitines-are-biomarkers-of-mitochondrial-myopathy
#5
Christoffer Rasmus Vissing, Morten Duno, Flemming Wibrand, Mette Christensen, John Vissing
CONTEXT: Plasma acylcarnitines are biomarkers of beta-oxidation and are useful in diagnosing several inborn errors of metabolism but has never been systematically investigated in patients with mitochondrial myopathy. OBJECTIVE: We hypothesized that acylcarnitines can also be biomarkers of mitochondrial myopathy and sought to investigate the prevalence and pattern of elevated acylcarnitines. DESIGN: The study was a prospective cohort study of patients with confirmed mitochondrial myopathy followed at Copenhagen Neuromuscular Center, Rigshospitalet, Copenhagen, Denmark...
July 11, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290994/letter-to-the-editor-further-nonvertebral-fracture-reduction-beyond-3-years-for-up-to-10-years-of-denosumab-treatment
#6
Toshihiro Sugiyama
No abstract text is available yet for this article.
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290981/glucocorticoid-replacement-affects-serum-adiponectin-levels-and-hdl-c-in-patients-with-secondary-adrenal-insufficiency
#7
Reiko Hayashi, Daisuke Tamada, Masahiko Murata, Tetsuhiro Kitamura, Kosuke Mukai, Norikazu Maeda, Michio Otsuki, Iichiro Shimomura
CONTEXT: Low serum adiponectin and HDL-C levels are risk factors for cardiovascular disease. Patients with primary adrenal insufficiency are at higher risk of cardiovascular complications compared with healthy subjects. However, there is no information on the relationship between adiponectin and glucocorticoid replacement therapy in patients with secondary adrenal insufficiency (SAI). OBJECTIVE: To determine the effects of intrinsic adrenal function and glucocorticoid replacement therapy on serum adiponectin levels and lipid profile in patients with SAI...
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290977/longitudinal-phenotypes-of-type-1-diabetes-in-youth-based-on-weight-and-glycemia-and-their-association-with-complications
#8
Anna R Kahkoska, Crystal T Nguyen, Linda A Adair, Allison E Aiello, Kyle S Burger, John B Buse, Dana Dabelea, Lawrence M Dolan, Faisal S Malik, Amy K Mottl, Catherine Pihoker, Beth A Reboussin, Katherine A Sauder, Michael R Kosorok, Elizabeth J Mayer-Davis
CONTEXT: Subclinical and clinical complications emerge early in type 1 diabetes and may be associated with obesity and hyperglycemia. OBJECTIVE: Test how longitudinal 'weight-glycemia' phenotypes increase susceptibility to different patterns of early/subclinical complications among youth with type 1 diabetes. DESIGN: SEARCH for Diabetes in Youth observational study. SETTING: Population-based cohort. PARTICIPANTS: Youth with type 1 diabetes (n=570) diagnosed 2002-2006 or 2008...
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290976/letter-to-the-editor-ihh-gene-mutations-causing-short-stature-with-nonspecific-skeletal-abnormalities-and-response-to-growth-hormone-therapy
#9
Gianluca Tornese
No abstract text is available yet for this article.
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290968/reply-to-letter-to-the-editor-re-further-nonvertebral-fracture-reduction-beyond-3-years-for-up-to-10-years-of-denosumab-treatment
#10
Serge Ferrari
No abstract text is available yet for this article.
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290966/il13ra2-is-differentially-regulated-in-papillary-thyroid-carcinoma-versus-follicular-thyroid-carcinoma
#11
Siao Ting Chong, Khee Ming Tan, Catherine Y L Kok, Shou Ping Guan, Siang Hui Lai, Cindy Lim, Jiancheng Hu, Charles Sturgis, Charis Eng, Paula Y P Lam, Joanne Ngeow
CONTEXT: The interleukin-13 receptor alpha2 (IL13RA2), which is known to be overexpressed in glioblastoma multiforme, plays a role in various cellular processes such as cell migration that may contribute to tumor progression. Studies have attributed IL13RA2 to invasion and metastasis in cancers of the ovary, breast, and pancreas but the pathological role of IL13RA2 in thyroid cancer is still unclear. OBJECTIVE: This study aims to evaluate IL13RA2 expression in thyroid carcinomas and to examine the role of IL13RA2 in the progression of papillary thyroid cancer (PTC)...
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31290960/response-to-letter-to-the-editor-ihh-gene-mutations-causing-short-stature-with-nonspecific-skeletal-abnormalities-and-response-to-growth-hormone-therapy
#12
Gabriela A Vasques, Alexander A L Jorge
No abstract text is available yet for this article.
July 10, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287546/adrenalectomy-completely-cured-hypertension-in-familial-hyperaldosteronism-type-i-patients-with-somatic-kcnj5-mutation
#13
Yu-Fang Lin, Kang-Yung Peng, Chia-Hui Chang, Ya-Hui Hu, Vin-Cent Wu, Jeff S Chueh, Kwan-Dun Wu
CONTEXT: Familial hyperaldosteronism type I or glucocorticoid-remediable aldosteronism (FH-I; GRA) is caused by unequal crossing-over of the steroid 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. Somatic KCNJ5 mutations have not been reported in patients with GRA; therefore, the appropriate treatment and prognosis of such concurrent cases remain unknown. CASE DESCRIPTION: Two siblings of a Taiwanese family with GRA were found to have adrenal adenomas and somatic KCNJ5 mutations...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287545/endocrine-and-metabolic-disorders-in-survivors-of-childhood-cancers-and-health-related-quality-of-life-and-physical-activity
#14
Kamnesh R Pradhan, Yan Chen, Sogol Moustoufi-Moab, Kevin Krull, Kevin C Oeffinger, Charles Sklar, Gregory T Armstrong, Kirsten K Ness, Leslie Robison, Yutaka Yasui, Paul C Nathan
CONTEXT: Childhood cancer survivors experience chronic health conditions that impact health related quality of life (HRQOL) and participation in optimal physical activity. OBJECTIVE: The study aimed to determine independent effects of endocrine and metabolic disorders on HRQOL and physical activity. DESIGN, SETTING, AND PATIENTS: Retrospective cohort with longitudinal follow-up of survivors of childhood cancer enrolled in the North American Childhood Cancer Survivor Study...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287542/caffeine-type-of-coffee-and-risk-of-ovarian-cancer-a-dose-response-meta-analysis-of-prospective-studies
#15
Asma Salari-Moghaddam, Alireza Milajerdi, Pamela J Surkan, Bagher Larijani, Ahmad Esmaillzadeh
CONTEXT: Prospective studies on caffeine and different types of coffee intake in relation to the risk of ovarian cancer have shown conflicting results. OBJECTIVE: The aim of this study was to perform a dose-response meta-analysis of cohort studies on the association between dietary caffeine intake, different types of coffee consumption and risk of ovarian cancer. DATA SOURCES: PubMed/Medline, ISI Web of Science, Scopus and EMBASE were searched to identify relevant articles published until October 2018...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287541/genetic-evidence-of-the-association-of-deah-box-helicase-37-defects-with-46-xy-gonadal-dysgenesis-spectrum
#16
Thatiana Evilen da Silva, Nathalia Lisboa Gomes, Antonio Marcondes Lerário, Catherine Elizabeth Keegan, Mirian Yumi Nishi, Filomena Marino Carvalho, Eric Vilain, Hayk Barseghyanm, Alejandro Martinez-Aguayo, María Verónica Forclaz, Regina Papazian, Leila Cristina Pedroso de Paula, Eduardo Corrêa Costa, Luciani Renata Carvalho, Alexander A Jorge, Felipe Elias, Rod Mitchell, Elaine Maria Frade Costa, Berenice Bilharinho Mendonca, Sorahia Domenice
CONTEXT: 46,XY gonadal dysgenesis (GD) is a heterogeneous group of disorders with a wide phenotypic spectrum, including embryonic testicular regression syndrome (ETRS). OBJECTIVE: To report a novel gene for 46,XY GD etiology, especially for ETRS. DESIGN: Screening of familial cases of 46,XY GD using WES and sporadic cases by target gene panel sequencing. SETTING: Tertiary referral center for Differences/Disorders of sex Development (DSD)...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287540/the-association-between-vitamin-d-frailty-and-progression-of-frailty-in-community-dwelling-older-women
#17
David Buchebner, Patrik Bartosch, Linnea Malmgren, Fiona E McGuigan, Paul Gerdhem, Kristina E Akesson
BACKGROUND: Vitamin D (25OHD) plays a role in many physiological functions which decline with age, contributing to frailty and increased risk for negative health outcomes. However, whether 25OHD can be a long-term risk marker for frailty over a longer time-period and whether it is consistent with advancing age is unclear. OBJECTIVE: To investigate the association between 25OHD and frailty in women aged 75, followed for 10 years. DESIGN AND SETTING: Prospective, population-based, cohort study from Malmö, Sweden...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287539/quantitative-differences-in-tgf-%C3%AE-family-members-measured-in-small-antral-follicle-fluids-from-women-with-or-without-pco
#18
Stine Gry Kristensen, Ajay Kumar, Bhanu Kalra, Susanne Elisabeth Pors, Jane Alrø Bøtkjær, Linn Salto Mamsen, Lotte Berdiin Colmorn, Jens Fedder, Erik Ernst, Lisa Owens, Kate Hardy, Stephen Franks, Claus Yding Andersen
CONTEXT: Members of the Transforming-Growth-Factor-β (TGF-β) family have been implicated in aberrant follicle development in women with polycystic ovaries (PCO). OBJECTIVE: Are there quantitative differences in the concentrations of TGF-β family members in fluid from small antral follicles (hSAF) from women with or without PCO? DESIGN SETTING: & Follicle fluids (FF) were collected from 4-11 mm hSAF obtained from women undergoing ovarian tissue cryopreservation for fertility preservation...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287503/risk-prediction-scores-for-mortality-cerebrovascular-and-heart-disease-amongst-chinese-people-with-type-2-diabetes
#19
Jianchao Quan, Deanette Pang, Tom K Li, Cheung Hei Choi, Shing Chung Siu, Simon Y Tang, Nelson M Wat, Jean Woo, Zheng Yi Lau, Kelvin B Tan, Gabriel M Leung
CONTEXT: Risk scores for cardiovascular and mortality outcomes have not been commonly applied in Chinese populations. OBJECTIVE: To develop and externally validate a set of parsimonious risk scores (HKU-SG) to predict the risk of mortality, cerebrovascular disease and ischemic heart disease among Chinese people with type 2 diabetes; and compare HKU-SG risk scores to other existing ones. DESIGN: Retrospective population-based cohorts drawn from Hong Kong Hospital Authority health records from 2006 to 2014 for development and Singapore Ministry of Health records from 2008 to 2016 for validation...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31287502/neonatal-screening-for-congenital-hypothyroidism-what-can-we-learn-from-discordant-twins
#20
Emanuela Medda, Maria Cristina Vigone, Alessandra Cassio, Francesca Calaciura, Pietro Costa, Giovanna Weber, Tiziana de Filippis, Giulia Gelmini, Marianna Di Frenna, Silvana Caiulo, Rita Ortolano, Daniela Rotondi, Monica Bartolucci, Rossella Gelsomino, Simona De Angelis, Marco Gabbianelli, Luca Persani, Antonella Olivieri
CONTEXT: Newborn screening program for congenital hypothyroidism (CH) adopting re-screening in at-risk neonates. OBJECTIVES: To estimate the concordance rate for CH in twin pairs discordant at the first screening; to verify whether long-term follow-up of healthy cotwins belonging to CH discordant pairs may be useful to diagnose thyroid hypofunction during development; to evaluate the importance of genetic and environmental influences on liability to permanent and transient CH...
July 9, 2019: Journal of Clinical Endocrinology and Metabolism
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