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Journal of Clinical Endocrinology and Metabolism

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https://read.qxmd.com/read/30874808/altered-thyroid-function-and-structure-in-overweight-and-obese-children-and-adolescents-reversal-after-weight-loss
#1
Maria Rosaria Licenziati, Giuliana Valerio, Ilaria Vetrani, Gaetano De Maria, Fabrizia Liotta, Giorgio Radetti
CONTEXT: Obesity is associated with hypothyroidism and goiter. OBJECTIVE: The aim of the study was to verify whether thyroid structure and function would improve, after weight loss. DESIGN AND PATIENTS: We evaluated 96 overweight/obese children, who showed an altered parenchymal pattern at thyroid ultrasound without circulating anti-thyroid antibodies. At phase 1, BMI standard deviation score (SDS), body composition, fT4, TSH, high sensitivity C Reactive Protein (CRPhs), white blood cells (WBC), metabolic profile and a thyroid ultrasound were assessed...
March 15, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30874735/risk-stratification-in-differentiated-thyroid-cancer-from-detection-to-final-follow-up
#2
R Michael Tuttle, Ali S Alzahrani
CONTEXT: Modern management of differentiated thyroid cancer requires individualized care plans which tailor the intensity of therapy and follow-up to the estimated risks of recurrence and disease-specific mortality. EVIDENCE ACQUISITION: This summary is based on the authors' knowledge and extensive clinical experience supplemented by review of published review articles, thyroid cancer management guidelines, published staging systems, and original articles identified through a PubMed search which included terms such as risk stratification, staging, clinical outcomes, and differentiated thyroid cancer...
March 15, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30874733/bile-modulates-secretion-of-incretins-and-insulin-a-study-on-human-extrahepatic-cholestasis
#3
Teresa Mezza, Simona Moffa, Pietro M Ferraro, Giuseppe Quero, Umberto Capece, Andrea Carfì, Chiara M A Cefalo, Francesca Cinti, Gian Pio Sorice, Flavia Impronta, Andrea Mari, Alfredo Pontecorvi, Sergio Alfieri, Jens J Holst, Andrea Giaccari
OBJECTIVE: changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins leading to diabetes remission. However, the exact mechanism(s) involved are still unclear. We here propose an alternative method to investigate the relation between alterations in physiological bile flow and insulin and incretin secretion by studying the changes in gut-pancreatic function in extrahepatic cholestasis in non-diabetic humans. METHODS: to pursue this aim, 58 non-diabetic patients with recent diagnosis of periampullary tumors underwent an OGTT, and a subgroup of 16 patients also underwent 4-hour mixed meal tests and hyperinsulinemic euglycemic clamps...
March 15, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869797/pegvisomant-improves-glucose-metabolism-in-acromegaly-a-meta-analysis-of-prospective-interventional-studies
#4
Tiziana Feola, Alessia Cozzolino, Ilaria Simonelli, Emilia Sbardella, Carlotta Pozza, Elisa Giannetta, Daniele Gianfrilli, Patrizio Pasqualetti, Andrea Lenzi, Andrea M Isidori
INTRODUCTION: Pegvisomant (PEG) in monotherapy or combined with somatostatin analogs (SSAs) is used to control acromegaly, improving metabolism. However, the metabolic changes induced by PEG have not been systematically reviewed. OBJECTIVE: To address the following questions: Does 1) PEG or 2) the combination of PEG and SSAs affect fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), glucose load (2h-OGTT), insulin levels (FPI), homeostatic model assessment of insulin resistance and β-cell function (HOMA-I and HOMA-β), triglycerides (TGDs), total cholesterol, HDL-cholesterol, LDL-cholesterol or body mass index? 3) Are the effects disease-related or drug-related? DATA SOURCES: Indexed databases up to January 2019...
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869796/response-to-letter-to-the-editor-familial-hypercholesterolemia-and-increased-risk-of-peripheral-arterial-disease-is-there-a-role-for-lipoprotein-a
#5
Frida Emanuelsson, Børge G Nordestgaard, Marianne Benn
No abstract text is available yet for this article.
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869793/potential-role-of-metal-chelation-to-prevent-the-cardiovascular-complications-of-diabetes
#6
Rossana Calderon Moreno, Ana Navas-Acien, Esteban Escolar, David M Nathan, Jonathan Newman, John F Schmedtje, Denisse Diaz, Gervasio A Lamas, Vivian Fonseca
CONTEXT: For decades, there has been epidemiologic evidence linking chronic toxic metal exposure with cardiovascular disease, suggesting a therapeutic role for metal chelation. Given the lack of compelling scientific evidence however, the indications for metal chelation were never clearly defined. To determine the safety and efficacy of chelation therapy, the National Institutes of Health funded the Trial to Assess Chelation Therapy (TACT). TACT was the first double blind, randomized, controlled trial to demonstrate an improvement in cardiovascular outcomes with edetate disodium therapy in patients with prior myocardial infarction...
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869792/fibrogenesis-imperfecta-ossium-clinical-approach-to-diagnosis-and-management-of-a-rare-skeletal-disorder
#7
Ruban Dhaliwal, Vandana Dhiman, Sudhaker D Rao, Sanjay Kumar Bhadada
CONTEXT: Fibrogenesis imperfecta ossium (FIO) is a rare and progressive skeletal bone disorder of undetermined etiology. Given its FIO, the pathogenesis of FIO remains elusive and no effective treatment exists. Based on review of all published cases and our collective experience of FIO, we offer a comprehensive approach for the diagnosis and management of this complex and fatal disorder. EVIDENCE ACQUISITION: A review of electronic and print medical literature comprising case reports and articles retrieved from PubMed database up to March 2018 was conducted using the search term "fibrogenesis imperfecta"...
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869791/high-density-lipoprotein-cholesterol-and-all-cause-and-cause-specific-mortality-among-the-elderly
#8
Zhi-Hao Li, Yue-Bin Lv, Wen-Fang Zhong, Xiang Gao, Virginia Byers Kraus, Meng-Chen Zou, Xi-Ru Zhang, Fu-Rong Li, Jin-Qiu Yuan, Xiao-Ming Shi, Xian-Bo Wu, Chen Mao
CONTEXT: The patterns of the association between high-density lipoprotein cholesterol (HDL-C) concentrations and mortality among the elderly are still unclear. OBJECTIVE: To examine the association of HDL-C concentrations with mortality, and to identify the optimal HDL-C concentration range that predicts the lowest risk of all-cause mortality among the elderly. DESIGN: This was a nationwide, community-based prospective cohort study. METHODS: This study included 7,766 elderly individuals (aged ≥65 years; mean age: 74...
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869790/isocaloric-fructose-restriction-reduces-serum-d-lactate-concentration-in-children-with-obesity-and-metabolic-syndrome
#9
Ayca Erkin-Cakmak, Yasmin Bains, Russell Caccavello, Susan M Noworolski, Jean-Marc Schwarz, Kathleen Mulligan, Robert H Lustig, Alejandro Gugliucci
OBJECTIVE: To investigate the link between dietary sugar consumption and two separate pathogenetic mechanisms associated with metabolic syndrome: de novo lipogenesis (DNL) and non-enzymatic glycation. DESIGN AND PARTICIPANTS: We assessed changes in serum D-lactate (the detoxification end-product of methylglyoxal) concentration in response to nine days of isocaloric fructose restriction in 20 children with obesity and metabolic syndrome, and examined correlations with changes in DNL, liver fat, insulin sensitivity and other metrics of hepatic metabolism...
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30869788/letter-to-the-editor-familial-hypercholesterolemia-and-increased-risk-of-peripheral-artery-disease-is-there-a-role-for-lipoprotein-a
#10
Panagiotis Anagnostis, Dimitrios G Goulis
No abstract text is available yet for this article.
March 14, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30865229/combined-gestational-age-and-birth-weight-adjusted-cutoffs-for-newborn-screening-of-congenital-adrenal-hyperplasia
#11
Naomi Pode-Shakked, Ayala Blau, Ben Pode-Shakked, Dov Tiosano, Naomi Weintrob, Ori Eyal, Amnon Zung, Floris Levy-Khademi, Yardena Tenenbaum-Rakover, David Zangen, David Gillis, Orit Pinhas-Hamiel, Neta Loewenthal, Liat de Vries, Zohar Landau, Mariana Rachmiel, Abdulsalam Abu-Libdeh, Alon Eliakim, David Strich, Ilana Koren, Alina German, Joseph Sack, Shlomo Almashanu
CONTEXT: Congenital Adrenal Hyperplasia (CAH) was among the first genetic disorders included in newborn screening (NBS) programs worldwide, based on 17α-hydroxyprogesterone (17-OHP) levels in dried blood spots. However, the success of NBS for CAH is hampered by high rates of false positive (FP) rates, especially in preterm and low birth-weight infants. OBJECTIVE: To establish a set of cutoff values adjusting for both gestational-age (GA) and birth-weight (BW), with the aim of reducing FP rates...
March 13, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30865228/pth-modulation-by-aldosterone-and-angiotensin-ii-is-blunted-in-hyperaldosteronism-and-rescued-by-adrenalectomy
#12
Livia Lenzini, Selene Prisco, Paul Emmanuel Vanderriele, Silvia Lerco, Francesca Torresan, Giuseppe Maiolino, Teresa Maria Seccia, Maurizio Iacobone, Gian Paolo Rossi
CONTEXT: Accumulating evidences suggest a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored. OBJECTIVES: To test the hypothesis that in vivo Angiotensin (Ang) II blockade affects parathyroid hormone (PTH) secretion in hypertensive patients and that aldosterone and Ang II directly stimulate PTH secretion ex vivo. DESIGN AND SETTING: We investigated the changes of serum PTH levels induced by oral captopril (50 mg) administration in patients with primary essential hypertension (EH) and with primary aldosteronism (PA) due to bilateral adrenal hyperplasia (BAH) or to aldosterone-producing adenoma (APA), the latter before and after adrenalectomy...
March 13, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30865224/impaired-glucose-metabolism-in-primary-aldosteronism-is-associated-with-cortisol-co-secretion
#13
Judith Gerards, Daniel A Heinrich, Christian Adolf, Christa Meisinger, Wolfgang Rathmann, Lisa Sturm, Nina Nirschl, Martin Bidlingmaier, Felix Beuschlein, Barbara Thorand, Annette Peters, Martin Reincke, Michael Roden, Marcus Quinkler
CONTEXT: Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and metabolic risks. Recent studies report glucocorticoid co-secretion as a relevant phenotype of PA, which could contribute to associated risks, including type 2 diabetes mellitus (T2DM). The relationship between autonomous cortisol secretion (ACS) and glucose metabolism in PA has not been investigated. OBJECTIVE: To evaluate the prevalence of impaired glucose homeostasis in PA patients according to cortisol co-secretion...
March 13, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860591/letter-to-the-editor-progesterone-is-important-for-transwomen-s-therapy-applying-evidence-for-the-benefits-of-progesterone-in-ciswomen
#14
Sean J Iwamoto, Guy T'Sjoen, Joshua D Safer, Caroline J Davidge-Pitts, Margaret E Wierman, Michele B Glodowski, Micol S Rothman
No abstract text is available yet for this article.
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860588/effect-of-parathyroidectomy-on-cardiovascular-risk-factors-in-primary-hyperparathyroidism-a-randomised-clinical-trial
#15
Henriette Ejlsmark-Svensson, Lars Rolighed, Lars Rejnmark
CONTEXT: It remains unclear whether risk of cardiovascular diseases is increased in patients with mild (˂1.45 mmol/l) to moderate (≥1.45-1.60 mmol/l) primary hyperparathyroidism (PHPT). OBJECTIVE: We aimed to determine the short-term effect of parathyroidectomy (PTX) on arterial stiffness, cholesterol levels, and blood pressure (BP). DESIGN: This study was a clinical trial randomly allocating patients to either PTX- or a control-group (no surgery)...
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860587/corrigendum-for-pilot-dose-comparison-of-apatinib-in-chinese-patients-with-progressive-radioiodine-refractory-differentiated-thyroid-cancer
#16
(no author information available yet)
No abstract text is available yet for this article.
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860584/enteroendocrine-connections-in-congenital-isolated-gh-deficiency-due-to-a-ghrh-receptor-gene-mutation
#17
Alécia A Oliveira-Santos, Roberto Salvatori, Monica C Nogueira, Ana C Bueno, Cynthia S Barros-Oliveira, Ângela C G B Leal, Cindi G Marinho, Nayra P Damascena, Djane A Oliveira, Manuela A Melo, Carla R P Oliveira, Flavia O da Costa, Jéssica S S Dos Santos, Paula F C Santos, Viviane C Campos, Elenilde G Santos, Enaldo V Melo, Meirielly L A Barbosa, Ivina E S Rocha, Margaret de Castro, Manuel H Aguiar-Oliveira
CONTEXT: GH and IGF-I are crucial for attainment of normal body size and regulation of food intake, nutrients storage, and insulin sensitivity. Enteroendocrine connections exist between the GH/IGF-I axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. OBJECTIVE: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene...
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860583/response-to-letter-to-the-editor-progesterone-is-important-for-transwomen-s-therapy-applying-evidence-for-the-benefits-of-progesterone-in-ciswomen
#18
Jerilynn C Prior
No abstract text is available yet for this article.
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860580/biguanides-exert-antitumoral-actions-in-pituitary-tumor-cells-through-ampk-dependent-and-independent-mechanisms
#19
Mari C Vázquez-Borrego, Antonio C Fuentes-Fayos, Aura D Herrera Martínez, Fernando L-López, Alejandro Ibáñez-Costa, Paloma Moreno Moreno, María R Alhambra-Expósito, Ana Barrera-Martín, Cristóbal Blanco-Acevedo, Elena Dios, Eva Venegas-Moreno, Juan Solivera, Manuel D Gahete, Alfonso Soto-Moreno, María A Gálvez-Moreno, Justo P Castaño, Raúl M Luque
CONTEXT: Pituitary neuroendocrine tumors (PitNETs) comprise a commonly underestimated pathology in terms of incidence and associated morbimortality. Currently, an appreciable subset of patients is resistant or poorly responsive to the main current medical treatments [i.e. somatostatin-analogues (SSAs)/dopamine-agonists]. Thus, development/optimization of novel/available medical therapies is necessary. Biguanides (metformin/buformin/phenformin) are antidiabetic drugs that exert antitumoral actions in several tumor types, but their pharmacological effects on PitNETs are poorly known...
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30860579/long-term-efficacy-of-a-single-session-rfa-of-benign-thyroid-nodules-a-longitudinal-5-year-observational-study
#20
M Deandrea, P Trimboli, F Garino, A Mormile, G Magliona, M J Ramunni, L Giovanella, P P Limone
CONTEXT: Radiofrequency ablation (RFA) of benign thyroid nodules has been gaining consensus. However, solid information on its long-term efficacy is yet to be obtained. OBJECTIVE: To analyze the long-term results of single-session RFA. DESIGN: Retrospective longitudinal observational study. SETTING: Primary care center. PATIENTS OR OTHER PARTICIPANTS: Adult outpatients who underwent a single-session RFA and post-treatment follow-up of at least three years...
March 12, 2019: Journal of Clinical Endocrinology and Metabolism
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