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Journal of Clinical Endocrinology and Metabolism

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https://read.qxmd.com/read/31513709/development-of-an-adrenocortical-cancer-humanized-mouse-model-to-characterize-anti-pd1-effects-on-tumor-microenvironment
#1
Julie Lang, Anna Capasso, Kimberly R Jordan, Jena D French, Adwitiya Kar, Stacey M Bagby, Jacob Barbee, Betelehem W Yacob, Lia S Head, Kenneth D Tompkins, Brian M Freed, Hilary Somerset, Toshimasa J Clark, Todd M Pitts, Wells A Messersmith, S Gail Eckhardt, Margaret E Wierman, Stephen Leong, Katja Kiseljak-Vassiliades
CONTEXT: While the development of immune checkpoint inhibitors has transformed treatment strategies of several human malignancies, research models to study immunotherapy in ACC are lacking. OBJECTIVE: To explore the effect of anti-PD1 immunotherapy on the alteration of the immune milieu in ACC in a newly generated preclinical model and correlate with the response of the matched patient. DESIGN, SETTING AND INTERVENTION: To characterize the CU-ACC2-M2B patient-derived xenograft in a humanized mouse model, evaluate the effect of a PD-1 inhibitor therapy and compare to the CU-ACC2 patient with metastatic disease...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31513265/high-fat-overfeeding-impairs-peripheral-glucose-metabolism-and-muscle-microvascular-enos-ser1177-phosphorylation
#2
Siôn A Parry, Mark C Turner, Rachel M Woods, Lewis J James, Richard A Ferguson, Matthew Cocks, Katie L Whytock, Juliette A Strauss, Sam O Shepherd, Anton J M Wagenmakers, Gerrit van Hall, Carl J Hulston
CONTEXT: The mechanisms responsible for dietary fat-induced insulin resistance of skeletal muscle and its microvasculature are only partially understood. OBJECTIVE: To determine the impact of high-fat overfeeding on postprandial glucose fluxes, muscle insulin signaling, and muscle microvascular eNOS content and activation. DESIGN: Fifteen non-obese volunteers consumed a high-fat (64%) high-energy (+47%) diet for 7 days. Experiments were performed before and after the diet...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31513250/efficacy-and-safety-of-first-and-second-line-drugs-to-prevent-glucocorticoid-induced-fractures-a-network-meta-analysis
#3
Liangliang Ding, Jinxi Hu, Dehua Wang, Qi Liu, Yuxia Mo, Xiang Tan, Fei Wen
CONTEXT: The evidence about benefits and harms of drugs for glucocorticoid-induced osteoporosis (GIOP) is limited, and the comparative efficacy and safety of first-line and second-line agents to prevent glucocorticoid-induced (GI) fractures remains unclear. OBJECTIVE: To assess the comparative clinical efficacy, safety and tolerability of first-line and second-line agents in preventing GI fractures. DATA SOURCES: We searched three different databases through March 5, 2019...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31512728/a-novel-anti-cd40-monoclonal-antibody-iscalimab-for-control-of-graves-hyperthyroidism-a-proof-of-concept-trial
#4
G J Kahaly, M N Stan, L Frommer, P Gergely, L Colin, A Amer, I Schuhmann, P Espie, J S Rush, C Basson, Y L He
CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation. OBJECTIVE: Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD. DESIGN: Open label, phase II proof-of-concept study. SETTING: Multicenter. PATIENTS: Fifteen with GD...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31512726/mitochondrial-dysfunction-induced-by-high-estradiol-concentrations-in-endometrial-epithelial-cells
#5
Chia-Hung Chou, Shee-Uan Chen, Chin-Der Chen, Chia-Tung Shun, Wen-Fen Wen, Yi-An Tu, Jehn-Hsiahn Yang
CONTEXT: A supraphysiological estradiol (E2) concentration after ovarian stimulation is known to result in lower embryo implantation rates in in vitro fertilization (IVF). Endometrial epithelial cells (EECs) apoptosis occurs after the stimulation with high E2 concentrations, and mitochondria play important roles in cell apoptosis. OBJECTIVE: To investigate the mitochondrial function in EECs after the stimulation with high E2 concentrations. MATERIALS AND METHODS: Human EECs were purified and cultured with different E2 concentrations (10-10, 10-9, 10-8, 10-7 M) in vitro, in which 10-7 M is supraphysiologically high...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31512724/ampk-subunits-harbor-largely-non-overlapping-genetic-determinants-for-body-fat-mass-glucose-and-cholesterol-metabolism
#6
Elko Randrianarisoa, Angela Lehn-Stefan, Johannes Krier, Anja Böhm, Martin Heni, Martin Hrabě de Angelis, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Harald Staiger
CONTEXT: AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all seven subunit genes on adiposity, glucose- and lipid metabolism has not been systematically studied yet. OBJECTIVE: To analyze the associations of common SNPs in all AMPK genes, and of different scores thereof, with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-, LDL- and HDL-cholesterol and triglycerides...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31512719/uterine-fluid-proteins-for-minimally-invasive-assessment-of-endometrial-receptivity
#7
Sergo Kasvandik, Merilin Saarma, Tanel Kaart, Ilmatar Rooda, Agne-Velthut Meikas, Aivar Ehrenberg, Kristina Gemzell, Parameswaran Grace Lalitkumar, Andres Salumets, Maire Peters
CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement or disruption of window of implantation (WOI) in patients with recurrent implantation failure (RIF). However, biopsies are invasive and cannot be performed in the same cycle with IVF embryo transfer, while uterine fluid (UF) analysis is considered minimally invasive and can immediately precede embryo transfer...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511880/differential-resting-state-connectivity-responses-to-glycemic-state-in-type-1-diabetes
#8
Lisa Parikh, Dongju Seo, Cheryl Lacadie, Renata Belfort-DeAguiar, Derek Groskreutz, Muhammad Hamza, Feng Dai, Dustin Scheinost, Rajita Sinha, R Todd Constable, Robert Sherwin, Janice Jin Hwang
CONTEXT: Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain's resting state activity remains unclear. OBJECTIVE: To determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware)...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511876/differential-resting-state-connectivity-responses-to-glycemic-state-in-type-1-diabetes
#9
Lisa Parikh, Dongju Seo, Cheryl Lacadie, Renata Belfort-DeAguiar, Derek Groskreutz, Muhammad Hamza, Feng Dai, Dustin Scheinost, Rajita Sinha, R Todd Constable, Robert Sherwin, Janice Jin Hwang
CONTEXT: Individuals with type 1 diabetes (T1DM) have alterations in brain activity which have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain's resting state activity remains unclear. OBJECTIVE: To determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware)...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511874/opioids-and-their-endocrine-effects-a-systematic-review-and-meta-analysis
#10
Friso de Vries, Mees Bruin, Daniel J Lobatto, Olaf M Dekkers, Jan W Schoones, Wouter R van Furth, Alberto M Pereira, Niki Karavitaki, Nienke R Biermasz, Amir H Zamanipoor Najafabadi
CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo-pituitary-end organ hormone axes, remains unclear. OBJECTIVE: The aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function. METHODS: Eight electronic databases were searched for articles published up to May 8, 2018...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511871/uterine-fluid-proteins-for-minimally-invasive-assessment-of-endometrial-receptivity
#11
Sergo Kasvandik, Merilin Saarma, Tanel Kaart, Ilmatar Rooda, Agne-Velthut Meikas, Aivar Ehrenberg, Kristina Gemzell, Parameswaran Grace Lalitkumar, Andres Salumets, Maire Peters
CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement or disruption of window of implantation (WOI) in patients with recurrent implantation failure (RIF). However, biopsies are invasive and cannot be performed in the same cycle with IVF embryo transfer, while uterine fluid (UF) analysis is considered minimally invasive and can immediately precede embryo transfer...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511870/opioids-and-their-endocrine-effects-a-systematic-review-and-meta-analysis
#12
Friso de Vries, Mees Bruin, Daniel J Lobatto, Olaf M Dekkers, Jan W Schoones, Wouter R van Furth, Alberto M Pereira, Niki Karavitaki, Nienke R Biermasz, Amir H Zamanipoor Najafabadi
CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo-pituitary-end organ hormone axes, remains unclear. OBJECTIVE: The aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function. METHODS: Eight electronic databases were searched for articles published up to May 8, 2018...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511869/uterine-fluid-proteins-for-minimally-invasive-assessment-of-endometrial-receptivity
#13
Sergo Kasvandik, Merilin Saarma, Tanel Kaart, Ilmatar Rooda, Agne-Velthut Meikas, Aivar Ehrenberg, Kristina Gemzell, Parameswaran Grace Lalitkumar, Andres Salumets, Maire Peters
CONTEXT: Clinically used endometrial (EM) receptivity assays are based on transcriptomic patterning of biopsies at mid-secretory endometrium (MSE) to identify the possible displacement or disruption of window of implantation (WOI) in patients with recurrent implantation failure (RIF). However, biopsies are invasive and cannot be performed in the same cycle with IVF embryo transfer, while uterine fluid (UF) analysis is considered minimally invasive and can immediately precede embryo transfer...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511868/ampk-subunits-harbor-largely-non-overlapping-genetic-determinants-for-body-fat-mass-glucose-and-cholesterol-metabolism
#14
Elko Randrianarisoa, Angela Lehn-Stefan, Johannes Krier, Anja Böhm, Martin Heni, Martin Hrabě de Angelis, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Harald Staiger
CONTEXT: AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all seven subunit genes on adiposity, glucose- and lipid metabolism has not been systematically studied yet. OBJECTIVE: To analyze the associations of common SNPs in all AMPK genes, and of different scores thereof, with adiposity, insulin sensitivity, insulin secretion, blood glucose, total-, LDL- and HDL-cholesterol and triglycerides...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511866/a-novel-anti-cd40-monoclonal-antibody-iscalimab-for-control-of-graves-hyperthyroidism-a-proof-of-concept-trial
#15
G J Kahaly, M N Stan, L Frommer, P Gergely, L Colin, A Amer, I Schuhmann, P Espie, J S Rush, C Basson, Y L He
CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation. OBJECTIVE: Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD. DESIGN: Open label, phase II proof-of-concept study. SETTING: Multicenter. PATIENTS: Fifteen with GD...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511865/a-novel-anti-cd40-monoclonal-antibody-iscalimab-for-control-of-graves-hyperthyroidism-a-proof-of-concept-trial
#16
G J Kahaly, M N Stan, L Frommer, P Gergely, L Colin, A Amer, I Schuhmann, P Espie, J S Rush, C Basson, Y L He
CONTEXT: The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves' disease (GD) by promoting auto-reactive B cell activation. OBJECTIVE: Evaluate efficacy and safety of a human, blocking, non-depleting anti-CD40 monoclonal antibody, iscalimab, in hyperthyroid patients with GD. DESIGN: Open label, phase II proof-of-concept study. SETTING: Multicenter. PATIENTS: Fifteen with GD...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511864/mitochondrial-dysfunction-induced-by-high-estradiol-concentrations-in-endometrial-epithelial-cells
#17
Chia-Hung Chou, Shee-Uan Chen, Chin-Der Chen, Chia-Tung Shun, Wen-Fen Wen, Yi-An Tu, Jehn-Hsiahn Yang
CONTEXT: A supraphysiological estradiol (E2) concentration after ovarian stimulation is known to result in lower embryo implantation rates in in vitro fertilization (IVF). Endometrial epithelial cells (EECs) apoptosis occurs after the stimulation with high E2 concentrations, and mitochondria play important roles in cell apoptosis. OBJECTIVE: To investigate the mitochondrial function in EECs after the stimulation with high E2 concentrations. MATERIALS AND METHODS: Human EECs were purified and cultured with different E2 concentrations (10-10, 10-9, 10-8, 10-7 M) in vitro, in which 10-7 M is supraphysiologically high...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31511863/opioids-and-their-endocrine-effects-a-systematic-review-and-meta-analysis
#18
Friso de Vries, Mees Bruin, Daniel J Lobatto, Olaf M Dekkers, Jan W Schoones, Wouter R van Furth, Alberto M Pereira, Niki Karavitaki, Nienke R Biermasz, Amir H Zamanipoor Najafabadi
CONTEXT: The increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo-pituitary-end organ hormone axes, remains unclear. OBJECTIVE: The aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function. METHODS: Eight electronic databases were searched for articles published up to May 8, 2018...
September 12, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31415089/factors-associated-with-diagnosis-and-treatment-of-thyroid-microcarcinomas
#19
Nazanene H Esfandiari, David T Hughes, David Reyes-Gastelum, Kevin C Ward, Ann S Hamilton, Megan R Haymart
CONTEXT: Nearly one-third of all thyroid cancers are ≤ 1 cm. OBJECTIVE: Determine diagnostic pathways for microcarcinomas versus larger cancers. DESIGN/SETTING/PATIENT PARTICIPANTS: Patients from Georgia and Los Angeles Surveillance, Epidemiology, and End Results (SEER) registries with differentiated thyroid cancer diagnosed in 2014-2015 were surveyed (response rate 63%). Survey data were linked to SEER data on tumor and treatment characteristics...
August 15, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/31415087/treatment-of-menopausal-vasomotor-symptoms-with-fezolinetant-a-neurokinin-3-receptor-antagonist-a-phase-2a-trial
#20
Dirk Timmerman, Gilbert Donders, Peter Sieprath, Steven Ramael, Jean Combalbert, Hamid R Hoveyda, Graeme L Fraser, Herman Depypere
CONTEXT: The thermoregulatory center in the hypothalamus is stimulated by neurokinin 3 receptor (NK3R) activation and inhibited by estrogen negative-feedback. This balance is disrupted in menopause, producing vasomotor symptoms (VMS). Objective: To evaluate safety and efficacy of the NK3R antagonist fezolinetant in menopausal VMS. Design: 12-week, double-blind, randomized, placebo-controlled study. SETTING: Eight Belgian centers from September 2015 to October 2016...
August 15, 2019: Journal of Clinical Endocrinology and Metabolism
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