Rebeca Eriksen, Margaret C White, Adem Y Dawed, Isabel Garcia Perez, Joram M Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E Thomas, Robert W Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N Giordano, Imre Pavo, Jochen M Schwenk, Federico De Masi, Konstantinos D Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J McDonald, Tarja Kokkola, Femke Rutters, Joline Beulens, Mirthe Muilwijk, Marieke Blom, Petra Elders, Tue H Hansen, Juan Fernandez-Tajes, Angus Jones, Chris Jennison, Mark Walker, Mark I McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jens J Holst, Henrik S Thomsen, Martin Ridderstråle, Jimmy D Bell, Jerzy Adamski, Paul W Franks, Torben Hansen, Elaine Holmes, Gary Frost, Ewan R Pearson
CONTEXT: The role of glucagon-like peptide-1(GLP-1) in Type 2 diabetes (T2D) and obesity is not fully understood. OBJECTIVE: We investigate the association of cardiometabolic, diet and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. METHOD: We analysed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1(n=2127) individuals at risk of diabetes; cohort 2 (n=789) individuals with new-onset of T2D...
April 30, 2024: Journal of Clinical Endocrinology and Metabolism