Journal of Clinical Endocrinology and Metabolism

No abstract text is available yet for this article.

No abstract text is available yet for this article.

CONTEXT: U.S. papillary thyroid carcinoma (PTC) incidence recently declined for the first time in decades, for reasons that remain unclear. OBJECTIVE: To evaluate PTC incidence trends, including by histologic subtype and size, and non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). DESIGN: Descriptive study using U.S. Surveillance, Epidemiology, and End Results (SEER)-18 cancer registry data (2000-17). PATIENTS: Individuals diagnosed with PTC (2000-17) or NIFTP (2016-17)...

Metabolic homeostasis is achieved by endocrine factors, signaling cascades, and metabolic pathways that sense and respond to metabolic demands in different organs. However, the recent discovery that almost every component of this regulatory system is also modulated by circadian rhythm highlights novel etiology and prognosis of metabolic diseases. First, chronic circadian rhythm disruption, as in shiftwork or shiftwork-like lifestyle, can increase the risk for metabolic diseases. Second, by understanding factors that affect circadian rhythm, we can implement new behavioral or pharmacological interventions for the prevention and management of metabolic disorders...

The treatment of patients with progressive metastatic follicular cell-derived and medullary thyroid cancers that do not respond to standard therapeutic modalities presents a therapeutic challenge. As a deeper understanding of the molecular drivers for these tumors has occurred and more potent and specific compounds are developed, the number of FDA-approved treatments for thyroid cancer has expanded. In addition, with the advent of disease-agnostic target-directed FDA approvals an ever-broadening number of therapeutic options are available for clinicians and patients...

CONTEXT: CD34 + fibrocytes have been implicated in development of thyroid-associated ophthalmopathy (TAO), a consequential autoimmune manifestation of Graves' disease (GD). In TAO, CD34 + fibrocytes appear to masquerade as CD34 + orbital fibroblasts mixed with CD34 - OF (collectively, GD-OF). Slit2, an axon guidance glycoprotein, is expressed by CD34 - OF and attenuates GD-OF gene expression. Cardinal features of TAO include hyaluronan (HA) accumulation and cytokine-driven inflammation...

OBJECTIVE: To examine effects of common treatments for PCOS on a panel of hormones(reproductive/metabolic). DESIGN: Secondary analysis of blood from a RCT of three 16-week preconception interventions designed to improve PCOS-related abnormalities: continuous oral contraceptives(OCP, N=34 subjects), intensive lifestyle modification(Lifestyle, N =31) or combination of both(Combined, N=29). MATERIALS AND METHODS: Post-treatment levels of activin A and B, inhibin B and follistatin as well as IGF-1, IGFBP-2, glucagon, GLP-1 and 2 and Oxyntomodulin were compared to baseline and change from baseline in these parameters were correlated with outcomes...

CONTEXT: Gonadotropin releasing hormone agonist (GnRH-a) serves as an alternative to human chorionic gonadotropin (hCG) to trigger final oocyte maturation, while significantly reduces the risk of ovarian hyperstimulation syndrome (OHSS), probably by attenuating vascular/endothelial activation. OBJECTIVES: To compare the effect of different modes of final follicular maturation (hCG vs GnRH-a), following ovarian stimulation (OS) for in-vitro fertilization (IVF), on endothelial function...

No abstract text is available yet for this article.

CONTEXT: Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Further, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. OBJECTIVE: To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche...

CONTEXT: Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, yet current diagnostic criteria are ineffective at identifying patients whose symptoms reside outside strict diagnostic criteria. As a result, PCOS is under diagnosed and its etiology is poorly understood. OBJECTIVE: We aim to characterize the phenotypic spectrum of PCOS clinical features within and across racial and ethnic groups. METHODS: We developed a strictly defined PCOS algorithm (PCOSkeyword-strict) using International Classification of Diseases, 9 th and 10 th edition (ICD9/10) and keywords mined from clinical notes in electronic health records (EHRs) data...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

CONTEXT: Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia. OBJECTIVE: The aim of this systematic review was to investigate the impact of therapy for overt and subclinical hyper- and hypothyroidism on serum lipids. DATA SOURCES: We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through April 5, 2018...

BACKGROUND: Excess adipose tissue is associated with an abnormal lipid profile that may improve with weight reduction. In this meta-analysis, we aimed to estimate the magnitude of change in lipid parameters associated with weight loss in adults who are overweight or obese. METHODS: We searched MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, and Scopus from 2013 to September, 2018. We included randomized-controlled trials (RCTs) that evaluated interventions to treat adult obesity (lifestyle, pharmacologic and surgical) with ≥6-month follow-up...

OBJECTIVE: This guideline will provide the practicing endocrinologist with an approach to assessment and treatment of dyslipidemia in patients with endocrine diseases, with the objective of prevention of cardiovascular events and triglyceride-induced pancreatitis. The guideline reviews data on dyslipidemia and ASCVD risk in patients with endocrine disorders and discusses the evidence for correction of dyslipidemia by treatment of the endocrine disease. The guideline also addresses whether treatment of the endocrine disease reduces ASCVD risk...

CONTEXT: Higher fibroblast growth factor-23 (FGF23) concentrations are associated with heart failure and mortality in diverse populations, but the strengths of associations differ markedly depending upon which assay is used. OBJECTIVE: We sought to evaluate whether iron deficiency, inflammation, and kidney function account for differences in the strengths of associations between these two FGF23 assays with clinical outcomes. DESIGN: Case-cohort from the Cardiovascular Health Study...

No abstract text is available yet for this article.

No abstract text is available yet for this article.