journal
Journals Journal of Clinical Endocrinol...

Journal of Clinical Endocrinology and Metabolism

https://read.qxmd.com/read/38642404/hemostatic-effects-of-exercise-related-hypoglycemia-in-male-persons-with-type-1-diabetes
#1
JOURNAL ARTICLE
Per Gustav Hagelqvist, Andreas Andersen, Kaisar Maytham, Christine Rode Andreasen, Susanne Engberg, Ulrik Pedersen-Bjergaard, Julie Lyng Forman, Pär Johansson, Jens Lykkesfeldt, Filip Krag Knop, Tina Vilsbøll
CONTEXT: People with type 1 diabetes (T1D) are at increased risk of thrombosis, however, the underlying mechanisms remain unclear. Hypoglycemia induced at rest can induce coagulation activation, but little is known about the hemostatic effects of exercise-related hypoglycemia in people with T1D. OBJECTIVE: We compared hemostatic profiles of individuals with T1D with healthy controls and explored hemostatic effects of hypoglycemia, induced with or without exercise, in participants with T1D...
April 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38636099/ldl-c-and-tc-mediate-the-risk-of-pnpla3-inhibition-on-cardiovascular-diseases
#2
JOURNAL ARTICLE
Genshan Zhang, Wei Jiang, Fangxun He, Jie Fu, Xiangshang Xu, Xuelai Luo, Zhixin Cao
BACKGROUND: PNPLA3 is a promising target for the treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease. ARO-PNPLA3 is a drug that efficiently lowers PNPLA3 expression in hepatocytes at the mRNA level, resulting in a significant reduction in liver fat in Phase I clinical trials. However, the long-term effects and potential side effects of ARO-PNPLA3 are not well understood. METHODS: We conducted a two-sample, two-step Mendelian randomization (MR) analysis to investigate the association between PNPLA3 inhibition and 10 cardiovascular diseases (CVDs), as well as the role of lipid traits as mediators...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38636096/expression-of-bile-acid-receptors-and-transporters-along-the-intestine-of-patients-with-type-2-diabetes-and-controls
#3
JOURNAL ARTICLE
Henriette H Nerild, Hannah Gilliam-Vigh, Anne-Marie Ellegaard, Julie L Forman, Tina Vilsbøll, David P Sonne, Andreas Brønden, Filip K Knop
CONTEXT: The enterohepatic circulation of bile acids depends on intestinal absorption by bile acid transporters and activation of bile acid receptors, which stimulates secretion of hormones regulating glucose and lipid metabolism and appetite. Distribution of bile acid transporters and receptors in the human gut and their potential involvement in type 2 diabetes (T2D) pathophysiology remain unknown. OBJECTIVE: We explored the expression of genes involved in bile acid metabolism throughout the intestines of patients with T2D and matched healthy controls...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38635405/effects-of-hypertriglyceridemia-with-or-without-nefa-elevation-on-%C3%AE-cell-function-and-insulin-clearance-and-sensitivity
#4
JOURNAL ARTICLE
Domenico Tricò, Eleni Rebelos, Brenno Astiarraga, Simona Baldi, Tiziana Scozzaro, Luca Sacchetta, Martina Chiriacò, Andrea Mari, Ele Ferrannini, Elza Muscelli, Andrea Natali
AIMS: Hypertriglyceridemia is a risk factor for developing type 2 diabetes (T2D) and might contribute to its pathogenesis either directly or through elevation of non-esterified fatty acids (NEFAs). This study aimed at comparing the glucometabolic effects of acute hypertriglyceridemia alone or combined with NEFA elevation in non-diabetic subjects. METHODS: Twenty-two healthy lean volunteers underwent two 5-h intravenous infusions of either saline or Intralipid, without (n=12) or with heparin (I+H; n=10) to activate the release of NEFAs...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38635301/obesity-inflammation-and-clinical-outcomes-in-covid-19-a-multicenter-prospective-cohort-study
#5
JOURNAL ARTICLE
Christina G Hutten, Kishan Padalia, Alexi Vasbinder, Yiyuan Huang, Anis Ismail, Ian Pizzo, Kristen Machado Diaz, Tonimarie Catalan, Feriel Presswalla, Elizabeth Anderson, Grace Erne, Brayden Bitterman, Pennelope Blakely, Evangelos J Giamarellos-Bourboulis, Sven H Loosen, Frank Tacke, Athanasios Chalkias, Jochen Reiser, Jesper Eugen-Olsen, Mousumi Banerjee, Rodica Pop-Busui, Salim S Hayek
CONTEXT: Obesity is a risk factor for coronavirus disease 2019 (COVID-19)-related outcomes; however, the mechanism remains unclear. OBJECTIVE: The objective of this analysis was to determine whether inflammation mediates the association between obesity and COVID-19 outcomes. DESIGN: The International Study of Inflammation in Covid-19 (ISIC): A Prospective Multi-Center Observational Study Examining the Role of Biomarkers of Inflammation in Predicting Covid-19 Related Outcomes in Hospitalized Patients...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38635292/genetic-underpinnings-of-fasting-and-oral-glucose-stimulated-based-insulin-sensitivity-indices
#6
JOURNAL ARTICLE
Sufyan Suleman, Anne L Madsen, Lars H Ängquist, Mikkel Schubert, Allan Linneberg, Ruth J F Loos, Torben Hansen, Niels Grarup
CONTEXT: Insulin sensitivity (IS) is an important factor in type 2 diabetes (T2D) and can be estimated by many different indices. OBJECTIVE: We aimed to compare the genetic components underlying IS indices obtained from fasting and oral glucose-stimulated plasma glucose and serum insulin levels. METHODS: We computed 21 IS indices, classified as fasting, OGTT0,120 and OGTT0,30,120 indices, using fasting and oral glucose tolerance test (OGTT) data in two cohorts...
April 18, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38630627/correction-to-differential-diagnosis-of-post-pancreatitis-diabetes-mellitus-based-on-pancreatic-and-gut-hormone-characteristics
#7
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38630464/impact-of-oral-bisphosphonate-drug-holiday-on-mortality-following-hip-fracture-a-population-based-cohort-study
#8
JOURNAL ARTICLE
Miriam T Y Leung, Justin P Turner, Clara Marquina, Jenni Ilomaki, Tim Tran, J Simon Bell
CONTEXT: Current clinical guidelines recommend a drug holiday after extended use of oral bisphosphonates. However, no studies have investigated the impact of drug holidays before hip fractures on post-fracture mortality. OBJECTIVE: To investigate the effect of drug holiday on post-fracture mortality in patients with extended use of oral bisphosphonates. DESIGN: Retrospective population-based cohort study. SETTING: All patients with hip fractures in Victoria, Australia from 2014-18...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38630010/genomic-landscape-and-clinical-features-of-advanced-thyroid-carcinoma-a-national-database-study-in-japan
#9
JOURNAL ARTICLE
Soji Toda, Yukihiko Hiroshima, Hiroyuki Iwasaki, Katsuhiko Masudo
CONTEXT: The relationship between genomic profile and prognosis of advanced thyroid carcinoma requiring drug therapy has not been reported. OBJECTIVE: To evaluate the treatment period and overall survival time for each genetic alteration in advanced thyroid carcinoma that requires drug therapy. METHODS: We conducted a retrospective observational study using a national database in Japan, which included 552 cases of thyroid carcinoma out of 53,543 patients in the database...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38629916/genital-surgery-outcomes-using-an-individualized-algorithm-for-hormone-management-in-transfeminine-individuals
#10
JOURNAL ARTICLE
Justine Herndon, Nidhi Gupta, Caroline Davidge-Pitts, Nicole Imhof, Cesar Gonzalez, Sara Carlson, Marissa Will, Jorys Martinez-Jorge, Vahe Fahradyan, Lily Tamire, Anna Lin, Todd B Nippoldt, Alice Y Chang
CONTEXT: Transgender and gender diverse (TGD) individuals have greater access to genital surgery (GS) with improved insurance coverage and access to trained surgeons and interdisciplinary gender affirming providers. OBJECTIVE: To determine perioperative medical and behavioral health outcomes in transfeminine (TF) individuals undergoing GS with use of a specific gender-affirming hormone therapy (GAHT) algorithm based on individualized risk factor assessment. DESIGN: Retrospective observational cohort study from 2017-2022...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38629857/reply-to-letter-to-the-editor-from-a-h-jan-danser-and-ingrid-m-garrelds-the-clinical-impact-of-sample-storage-at-20%C3%A2-c-on-renin-reference-intervals-and-aldosterone-renin-ratio-calculations
#11
JOURNAL ARTICLE
Ömer Özcan, Jacquelien J Hillebrand, Wendy P J den Elzen, Annemieke C Heijboer
No abstract text is available yet for this article.
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38629854/approach-to-the-neonate-with-hypoglycemia
#12
JOURNAL ARTICLE
Katherine Lord, Diva D De León
After birth, healthy neonates undergo a period of altered glucose metabolism, known as "transitional hypoglycemia". During the first 0-4 hours of life, the mean plasma glucose concentration decreases to 57 mg/dL, then by 72-96 hours of life increases to 82 mg/dL, well within the normal adult range. Recent data suggests that transitional hypoglycemia is due to persistence of the fetal beta cell's lower threshold for insulin release, resulting in a transient hyperinsulinemic state. While hypoglycemia is an expected part of the transition to postnatal life, it makes the identification of infants with persistent hypoglycemia disorders challenging...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38629832/letter-to-the-editor-from-a-h-jan-danser-and-ingrid-m-garrelds-the-clinical-impact-of-sample-storage-at-20%C3%A2-c-on-renin-reference-intervals-and-aldosterone-renin-ratio-calculations
#13
JOURNAL ARTICLE
A H Jan Danser, Ingrid M Garrelds
No abstract text is available yet for this article.
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38627922/growth-and-adult-height-attainment-in-danish-transgender-adolescents-treated-with-gnrh-analog-and-sex-hormones
#14
JOURNAL ARTICLE
Pernille Badsberg Norup, Mette Ewers Haahr, Peter Christiansen, Lise Aksglaede, Line Cleemann, Trine Holm Johannsen, Anders Juul, Katharina M Main
BACKGROUND: Endogenous sex steroids influence the pubertal growth spurt and adult height. However, the impact of puberty suppression and sex steroids on growth in transgender adolescents is sparsely studied. AIM: We investigated pubertal growth, serum IGF-I and IGFBP-3, and adult height of transgender adolescents receiving hormone therapy. METHODS: Observational study of a national cohort (2016-2023) comprising 219 transgender adolescents <18 years of age...
April 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38626182/plasma-proteomics-of-diabetic-kidney-disease-among-asians-with-younger-onset-type-2-diabetes
#15
JOURNAL ARTICLE
Resham Lal Gurung, Huili Zheng, Hiromi Wai Ling Koh, M Yiamunaa, Jian-Jun Liu, Sylvia Liu, Clara Chan, Keven Ang, Clara Si Hua Tan, Radoslaw Mikolaj Sobota, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
CONTEXT: Patients with younger onset of type 2 diabetes (YT2D) have increased risk for kidney failure compared to those with late onset. However, the mechanism of diabetic kidney disease (DKD) progression in this high-risk group is poorly understood. OBJECTIVES: To identify novel biomarkers and potential causal proteins associated with DKD progression in patients with YT2D. DESIGN AND PARTICIPANTS: Among YT2D (T2D onset age ≤ 40 years), 144 DKD progressors (cases) were matched for T2D onset age, sex, and ethnicity with 292 non-progressors (controls) and divided into discovery and validation sets...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38626164/clinicopathological-and-molecular-profile-of-sellar-neurocytoma
#16
JOURNAL ARTICLE
Yulou Liu, Jing Guo, Jianhua Cheng, Qiuyue Fang, Dawei Wang, Weiyan Xie, Chuzhong Li
OBJECTIVE: To investigate the clinical features, imaging characteristics and molecular profile of Sellar neurocytoma (SN). METHODS: Clinical, imaging, and pathological features of eleven cases of sellar neurocytoma were retrospectively analyzed. Electron microscopy was performed in five cases. Molecular features were detected in tumor tissue by RNA sequencing, qPCR and IHC. RESULTS: The clinical features of SN patients showed high incidence of hyponatremia (73%,8/11) and the tumors tended to invaded lateral side of saddle area from preoperative imaging analysis...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38625929/prevalence-of-dysbetalipoproteinemia-in-the-uk-biobank-according-to-different-diagnostic-criteria
#17
JOURNAL ARTICLE
Martine Paquette, Mark Trinder, Simon-Pierre Guay, Liam R Brunham, Alexis Baass
CONTEXT: Dysbetalipoproteinemia (DBL) is a multifactorial disorder that disrupts the normal metabolism of remnant lipoproteins, causing increased risk of cardiovascular disease. However, establishing a proper diagnosis is difficult and the true prevalence of the disease in the general population remains unknown. OBJECTIVE: The objectives were to study the prevalence of the disease and to validate the performance of different clinical diagnostic criteria in a large population-based cohort...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38625914/association-of-acylcarnitines-with-maternal-cardiometabolic-risk-factors-is-defined-by-chain-length-the-s-presto-study
#18
JOURNAL ARTICLE
Li Chen, Xue Ping Goh, Anne K Bendt, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry K Y Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D Gluckman, Johan G Eriksson, Markus R Wenk, Sartaj Ahmad Mir
CONTEXT: Due to the essential role of carnitine as an intermediary in amino acid, carbohydrate and lipid metabolism, a detailed characterization of circulating and urinary carnitine concentrations will aid in elucidating the molecular basis of impaired maternal metabolic flexibility and facilitating timely intervention for expectant mothers. OBJECTIVE: To investigate the association of maternal plasma and urinary free carnitine and acylcarnitines with cardiometabolic risk factors...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38625900/dietary-n-3-fatty-acids-intake-and-all-cause-and-cardiovascular-mortality-in-patients-with-pre-diabetes-and-diabetes
#19
JOURNAL ARTICLE
Jinhang Che, Na He, Xue Kuang, Caiyin Zheng, Ruoyu Zhou, Xiaodan Zhan, Zengzhang Liu
BACKGROUND: While the association between n-3 polyunsaturated fatty acids (PUFA) and cardiovascular events has been thoroughly examined, there is still a scarcity of research regarding their impact on the long-term prognosis in diabetic patients. METHOD: Herein, a total of 16,539 eligible individuals were enrolled from the National Health and Nutrition Examination Survey (NHANES) 2003-2018, and categorized into T1, T2, and T3 based on the tertiles of n-3 PUFA. The Cox proportional risk regression models, Kaplan-Meier curve, and subgroup analysis were conducted to evaluate the association between n-3 PUFA and mortality...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38625888/genetic-susceptibility-mendelian-randomization-and-nomogram-model-construction-of-gestational-diabetes-mellitus
#20
JOURNAL ARTICLE
Qiulian Liang, Ming Li, Gongchen Huang, Ruiqi Li, Linyuan Qin, Ping Zhong, Xuekun Xing, Xiangyuan Yu
CONTEXT: Gestational diabetes mellitus (GDM) is a pregnancy complicated disease that poses a risk to maternal and infant health. However, the etiology of the disease has been not yet elucidated. OBJECTIVE: To detect the genetic susceptibility and construct a nomogram model with significantly associated polymorphisms and key clinical indicators for early prediction of gestational diabetes mellitus (GDM). METHODS: 11 functional single nucleotide polymorphisms (SNPs) screened by genome-wide association study (GWAS) were genotyped in 554 GDM cases and 641 healthy controls...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
journal
journal
20145
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.