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Journals Journal of Clinical Endocrinol...

Journal of Clinical Endocrinology and Metabolism

https://read.qxmd.com/read/39031583/serum-medium-chain-fatty-acids-and-the-risk-of-incident-diabetes-findings-from-the-4c-study
#1
JOURNAL ARTICLE
Xiaojing Jia, Hong Lin, Yilan Ding, Xuejiang Gu, Shuangyuan Wang, Yu Xu, Min Xu, Xinjie Zhao, Lulu Chen, Tianshu Zeng, Lixin Shi, Qing Su, Yuhong Chen, Xuefeng Yu, Li Yan, Guijun Qin, Qin Wan, Gang Chen, Xulei Tang, Zhengnan Gao, Feixia Shen, Ruying Hu, Zuojie Luo, Yingfen Qin, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Guixia Wang, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Yiming Mu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu
CONTEXT: Emerging studies have revealed associations between dietary medium-chain fatty acids (MCFAs) and glucose homeostasis. However, the relationship between serum MCFAs and the incidence of diabetes, and potential interactions with genetic predisposition, remains unclear in prospective cohort studies. OBJECTIVE: To investigate associations and genetic susceptibility between serum MCFAs and diabetes risk. METHODS: We investigated baseline serum MCFAs (n=5) in a nested case-control study comprising incident diabetes cases (n=1,707) and matched normoglycemic control subjects (n=1,707) from the China Cardiometabolic Disease and Cancer Cohort Study...
July 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39031569/risk-factors-for-adverse-outcomes-in-children-with-diabetic-ketoacidosis
#2
JOURNAL ARTICLE
Maha F Yousif, Katie D Dolak, Soumya Adhikari, Perrin C White
OBJECTIVE: Develop a multivariable model to identify children with diabetic ketoacidosis (DKA) and/or hyperglycemic hyperosmolar state (HHS) at increased risk of adverse outcomes, and apply it to analyze adverse outcomes during and after the COVID-19 pandemic. DESIGN: Retrospective review of clinical data from 4565 admissions (4284 with DKA alone, 31 [0.7%] only HHS, 250 [5.4%] hyperosmolar DKA) to a large academic children's hospital from January 2010-June 2023...
July 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39028964/letter-to-the-editor-from-van-os-et-al-persistently-decreased-quality-of-life-and-its-determinants-in-previous-illicit-androgen-users
#3
JOURNAL ARTICLE
Joël van Os, Diederik Laurens Smit, Willem de Ronde
No abstract text is available yet for this article.
July 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39028961/biologic-significance-of-the-short-tandem-trinucleotide-repeats-in-the-androgen-receptor-gene
#4
EDITORIAL
Shalender Bhasin
No abstract text is available yet for this article.
July 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39028959/response-to-letter-to-the-editor-from-van-os-et-al-persistently-decreased-quality-of-life-and-its-determinants-in-previous-illicit-androgen-users
#5
JOURNAL ARTICLE
Yeliz Bulut, Caroline Kistorp, Jon Jarløv Rasmussen
No abstract text is available yet for this article.
July 20, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39028757/sleep-duration-alters-overfeeding-mediated-reduction-in-insulin-sensitivity
#6
JOURNAL ARTICLE
Prachi Singh, Robbie A Beyl, Kara L Marlatt, Eric Ravussin
CONTEXT: Weight gain and sleep restriction both reduce insulin sensitivity. However, it is not known if sleep duration alters glucose metabolism in response to overfeeding. OBJECTIVE: To examine the effect of sleep duration on overfeeding-mediated alterations in carbohydrate metabolism and insulin sensitivity. METHODS: Retrospective exploratory analysis of a longitudinal overfeeding study in healthy participants (n = 28, age: 26.9 ± 5...
July 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39028731/us-based-prospective-blinded-study-of-thyrotropin-receptor-antibody-in-autoimmune-thyroid-disease
#7
JOURNAL ARTICLE
Mark A Lupo, Paul D Olivo, Maximilian Luffy, Jan Wolf, George J Kahaly
CONTEXT: Bioassays provide information on the functionality of thyrotropin receptor antibodies (TSH-R-Ab) and thus may offer more clinical utility than binding assays. OBJECTIVE: In this prospective, blinded, US-based study, the clinical performance of several TSH-R-Ab assays was compared. SETTING: US endocrinology clinic. SUBJECTS: One hundred sixty-two unselected, consecutive, well-documented patients with various thyroid diseases and healthy controls...
July 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39026459/endogenous-estrogens-and-brain-activation-during-verbal-memory-encoding-and-recognition-in-the-postmenopause
#8
JOURNAL ARTICLE
Rachel A Schroeder, Rebecca C Thurston, Minjie Wu, Howard J Aizenstein, Carol A Derby, Pauline M Maki
OBJECTIVE: Determine associations of endogenous estrogens with memory systems in the postmenopausal brain and evaluate clinical significance. STUDY DESIGN: In the MsBrain cohort (n=199, mean age 59.3+3.9 years, 83.9% white), we examined the cross-sectional association of serum estradiol and estrone, measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), during a functional magnetic resonance imaging (fMRI) task of word encoding and recognition...
July 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39026458/effects-of-intranasal-naloxone-on-hypoglycemia-associated-autonomic-failure-haaf-in-susceptible-individuals
#9
JOURNAL ARTICLE
Sandra Aleksic, Eric Lontchi-Yimagou, William Mitchell, Caroline Boyle, Priyanka Matias, Anjali Manavalan, Akankasha Goyal, Michelle Carey, Ilan Gabriely, Meredith Hawkins
CONTEXT: Hypoglycemia-associated autonomic failure (HAAF), defined as blunting of counter-regulatory hormone and symptom responses to recurrent hypoglycemia, remains a therapeutic challenge in diabetes treatment. The opioid system may play a role in HAAF pathogenesis since activation of opioid receptors induces HAAF. Blockade of opioid receptors with intravenous naloxone ameliorates HAAF experimentally, yet is not feasible therapeutically. OBJECTIVE: To investigate the effects of opioid receptor blockade with intranasal naloxone on experimentally-induced HAAF...
July 19, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39018443/pleiotropic-effects-of-an-eqtl-in-the-celsr2-psrc1-sort1-cluster-that-associates-with-ldl-c-and-resting-metabolic-rate
#10
JOURNAL ARTICLE
Khushdeep Bandesh, Kendrick Freeland, Michael Traurig, Robert L Hanson, Clifton Bogardus, Paolo Piaggi, Leslie J Baier
CONTEXT: The locus CELSR2-PSRC1-SORT1, a primary genetic signal for lipids, has recently been implicated in different metabolic processes. Our investigation identified its association with energy metabolism. OBJECTIVE: To determine biological mechanisms that govern diverse functions of this locus. METHODS: Genotypes for 491,265 variants in 7,000 clinically characterized American Indians were previously determined using a custom-designed array specific for this longitudinally studied American Indian population...
July 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39013141/longitudinal-evaluation-of-reproductive-endocrine-function-in-men-with-acth-dependent-cushing-syndrome
#11
JOURNAL ARTICLE
Skand Shekhar, Raven N McGlotten, Gordon B Cutler, Matthew J Crowley, Carl F Pieper, Lynnette K Nieman, Janet E Hall
CONTEXT: Hypogonadism may be caused by Cushing syndrome (CS) and may intensify its adverse consequences. OBJECTIVE: To determine the frequency of male hypogonadism before and after curative surgery for CS, and its cause. DESIGN: Post-hoc analyses of prospective cohort studies. SETTING: Clinical research center. PATIENTS: Men with ACTH-dependent CS. Cohort 1 (C1) (n=8, age 32.5±12 y; studied 1985-1989); Cohort 2 (C2) (n=44, 42...
July 17, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39011974/machine-learning-based-prediction-of-large-for-gestational-age-infants-in-mothers-with-gestational-diabetes-mellitus
#12
JOURNAL ARTICLE
Mei Kang, Chengguang Zhu, Mengyu Lai, Jianrong Weng, Yan Zhuang, Huichen He, Yan Qiu, Yixia Wu, Zhangxuan Qi, Weixia Zhang, Xianming Xu, Yanhong Zhu, Yufan Wang, Xiaokang Yang
CONTEXT: Large-for-gestational-age (LGA), one of the most common complications of gestational diabetes mellitus (GDM), has become a global concern. The predictive performance of common continuous glucose monitoring (CGM) metrics for LGA is limited. OBJECTIVE: We aimed to develop and validate an artificial intelligence (AI) based model to determine the probability of women with GDM giving birth to LGA infants during pregnancy using CGM measurements together with demographic data and metabolic indicators...
July 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39011972/the-effectiveness-and-safety-of-romosozumab-and-teriparatide-in-postmenopausal-women-with-osteoporosis
#13
JOURNAL ARTICLE
Martin C Hartz, Fabian B Johannessen, Torben Harsløf, Bente L Langdahl
PURPOSE: The purpose of this observational study was to investigate the effectiveness and safety of romosozumab (ROMO) and teriparatide (TPTD) in a clinical setting. METHODS: 315 postmenopausal women were included based on the reimbursement criteria for ROMO and TPTD at the Department of Endocrinology at Aarhus University Hospital. ROMO: Bone Mineral Density (BMD) T-score <-2.5 (femoral neck (FN), total hip (TH), or lumbar spine (LS)) + a fragility fracture (hip, spine, pelvis, distal forearm, or proximal humerus) within 3 years...
July 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39008612/letter-to-the-editor-from-fitzpatrick-et-al-zoledronate-after-denosumab-discontinuation-is-repeated-administrations-more-effective-than-single-infusion
#14
JOURNAL ARTICLE
Donal Fitzpatrick, Rosaleen Lannon, Kevin McCarroll
No abstract text is available yet for this article.
July 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39008610/response-to-letter-to-the-editor-from-fitzpatrick-et-al-zoledronate-after-denosumab-discontinuation-is-repeated-administrations-more-effective-than-single-infusion
#15
JOURNAL ARTICLE
Giorgia Grassi, Alberto Ghielmetti, Marta Zampogna, Iacopo Chiodini, Maura Arosio, Giovanna Mantovani, Cristina Eller-Vainicher
No abstract text is available yet for this article.
July 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39008607/insights-into-central-congenital-hypothyroidism-a-multicenter-retrospective-analysis
#16
JOURNAL ARTICLE
Alina German, Shlomo Almashanu, Liat de Vries, Merav Gil Margolis, Rana Halloun, Alon Haim, Ori Eyal, Floris Levy-Khademi, Dikla Pivko-Levy, Judith Nir, Orit Pinhas-Hamiel, Yardena Tenenbaum-Rakover
CONTEXT: Central congenital hypothyroidism (CCH) is a thyroid hormone deficiency at birth caused by inadequate pituitary stimulation of the thyroid gland. Although primary CH has been studied extensively, studies on CCH are sparse. OBJECTIVES: To assess the prevalence of CCH in Israel and describe its clinical features, neonatal screening results, and outcomes. DESIGN: Multicenter cross-sectional retrospective chart review. SETTING: Nine pediatric endocrine units throughout Israel...
July 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/39004834/paltusotine-a-step-towards-precision-medicine-in-acromegaly
#17
EDITORIAL
Frederic Castinetti, Thierry Brue
No abstract text is available yet for this article.
July 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38996042/early-appearance-of-thyroid-autoimmunity-in-children-followed-from-birth-for-type-1-diabetes-risk
#18
JOURNAL ARTICLE
Berglind Jonsdottir, Joanna L Clasen, Kendra Vehik, Åke Lernmark, Markus Lundgren, Ezio Bonifacio, Desmond Schatz, Anette-Gabriele Ziegler, William Hagopian, Marian Rewers, Richard McIndoe, Jorma Toppari, Jeffrey Krischer, Beena Akolkar, Andrea Steck, Riitta Veijola, Michael J Haller, Helena Elding Larsson
PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for type 1 diabetes. METHODS: TPOAb and TgAb seropositivity were determined in 5066 healthy children with HLA DR3 or DR4 containing haplogenotypes from The Environmental Determinants of Diabetes in the Young (TEDDY) Study...
July 12, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38996041/breast-cancer-is-increased-in-women-with-primary-ovarian-insufficiency
#19
JOURNAL ARTICLE
Kristina Allen-Brady, Barry Moore, Lauren E Verrilli, Margaret A Alvord, Marina Kern, Nicola Camp, Kristen Kelley, Joseph Letourneau, Lisa Cannon-Albright, Mark Yandell, Erica B Johnstone, Corrine K Welt
CONTEXT: DNA damage/repair gene variants are associated with both primary ovarian insufficiency (POI) and cancer risk. OBJECTIVE: We hypothesized that a subset of women with POI and family members would have increased risk for cancer. DESIGN: Case-control population-based study using records from 1995-2022. SETTING: Two major Utah academic healthcare systems serving 85% of the state. SUBJECTS: Women with POI (n=613) were identified using ICD codes and reviewed for accuracy...
July 12, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38994586/fish-oil-plasma-n-3-pufas-and-risk-of-macro-and-microvascular-complications-among-individuals-with-type-2-diabetes
#20
JOURNAL ARTICLE
Shufan Tian, Tianyu Guo, Frank Qian, Zixin Qiu, Qi Lu, Rui Li, Kai Zhu, Lin Li, Hancheng Yu, Ruyi Li, Yunjing Ou, An Pan, Gang Liu
OBJECTIVE: To evaluate associations of fish oil supplementation and plasma omega 3 polyunsaturated fatty acids (n-3 PUFAs) with risks of macrovascular and microvascular complications among people with type 2 diabetes, and to further explore the potential mediating role of metabolism-related biomarkers. RESEARCH DESIGN AND METHODS: This study included 20,338 participants with type 2 diabetes from UK Biobank. Diabetic complications were identified through hospital inpatient records...
July 12, 2024: Journal of Clinical Endocrinology and Metabolism
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