Alessa Fischer, Simon Kloos, Umberto Maccio, Juliane Friemel, Hanna Remde, Martin Fassnacht, Christina Pamporaki, Graeme Eisenhofer, Henri J L M Timmers, Mercedes Robledo, Stephanie M J Fliedner, Katharina Wang, Julian Maurer, Astrid Reul, Kathrin Zitzmann, Nicole Bechmann, Gintarė Žygienė, Susan Richter, Constanze Hantel, Diana Vetter, Kuno Lehmann, Hermine Mohr, Natalia S Pellegata, Martin Ullrich, Jens Pietzsch, Christian G Ziegler, Stefan R Bornstein, Matthias Kroiss, Martin Reincke, Karel Pacak, Ashley B Grossman, Felix Beuschlein, Svenja Nölting
CONTEXT: Pheochromocytomas/paragangliomas (PPGLs) with pathogenic mutations in the succinate dehydrogenase subunit B (SDHB) are associated with a high metastatic risk. Somatostatin receptor 2 (SSTR2)-dependent imaging is the most sensitive imaging modality for SDHB-related PPGLs, suggesting that SSTR2 expression is a significant cell surface therapeutic biomarker of such tumors. OBJECTIVE: Exploration of the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs...
March 22, 2023: Journal of Clinical Endocrinology and Metabolism