Journal of Clinical Endocrinology and Metabolism

Christian Adolf, Daniel A Heinrich, Finn Holler, Benjamin Lechner, Nina Nirschl, Lisa Sturm, Veronika Görge, Anna Riester, Tracy A Williams, Marcus Treitl, Roland Ladurner, Felix Beuschlein, Martin Reincke
CONTEXT: High dietary salt intake is known to aggravate arterial hypertension. This effect could be of particular relevance in the setting of primary aldosteronism (PA), which is associated with cardiovascular damage independent of blood pressure levels. The aim of this study was to determine the impact of therapy on salt intake in PA patients. PATIENTS AND METHODS: 148 consecutive PA patients (66 with unilateral and 82 with bilateral PA) from the database of the German Conn's Registry were included...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Elena Gonzalez Rodriguez, Mirah Stuber, Cinzia Del Giovane, Martin Feller, Tinh-Hai Collet, Axel L Löwe, Manuel R Blum, Nicolien A van Vliet, Diana van Heemst, Patricia M Kearney, Jacobijn Gussekloo, Simon Mooijaart, Rudi G J Westendorp, David J Stott, Daniel Aeberli, Douglas C Bauer, Didier Hans, Nicolas Rodondi
CONTEXT: Both thyroid dysfunction and levothyroxine therapy (LT4) have been associated with bone loss, but studies on the effect of LT4 for subclinical hypothyroidism (SHypo) on bone yielded conflicting results. OBJECTIVE: To assess the effect of LT4 treatment on bone mineral density (BMD), Trabecular Bone Score (TBS), and bone turnover markers (BTMs) in older adults with SHypo. DESIGN AND INTERVENTION: Planned nested substudy of the double-blind placebo-controlled TRUST trial...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Louise Cheryl Gregory, Mehul Tulsidas Dattani
CONTEXT: Congenital hypopituitarism (CH) is characterized by the presence of deficiencies in one or more of the six anterior pituitary (AP) hormones secreted from the five different specialized cell types of the AP. During human embryogenesis, hypothalamo-pituitary (HP) development is controlled by a complex spatio-temporal genetic cascade of transcription factors and signaling molecules within the hypothalamus and Rathke's pouch, the primordium of the AP. EVIDENCE ACQUISITION: This mini-review discusses the genes and pathways involved in HP development and how mutations of these give rise to CH...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Junfen Fu, Jianwei Zhang, Ruimin Chen, Xiaoyu Ma, Chunlin Wang, Linqi Chen, Yan Liang, Xiaoping Luo, Yu Yang, Feng Xiong, Zhe Su, Jing Wu, Hui Yao, Jinliang Xu, Di Wu, Yan Ni
CONTEXT: Gonadotropin-releasing hormone analogues (GnRHa) and recombinant human growth hormone (rhGH) have been widely used to treat idiopathic central precocious puberty (CPP) or early and fast puberty (EFP). However, large-scale studies to evaluate the treatment effects on final adult height (FAH) are still lacking. OBJECTIVE: To assess the effects of long-term treatment for CPP/EFP on FAH and its main influencing factors. DESIGN AND SETTING: Retrospective, multi-center observational study from 1998-2017...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Aglaia Kyrilli, David Gacquer, Vincent Detours, Anne Lefort, Frédéric Libert, Laure Twyffels, Laura Van den Eeckhaute, Aurélie Strickaert, Carine Maenhaut, Xavier De Deken, Jacques Emile Dumont, Françoise Miot, Bernard Corvilain
BACKGROUND: The early molecular events in human thyrocytes after 131I exposure have not yet been unravelled. Therefore, we investigated the role of thyrotropin (TSH) in the 131I-induced DNA damage response and gene expression in primary cultured human thyrocytes. METHODS: Following exposure of thyrocytes, in the presence or absence of TSH, to 131I (β radiation), γ radiation (3 Gy) and hydrogen peroxide (H2O2), we assessed DNA damage, proliferation and cell cycle status...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Alireza Ghajar, Pamela Jones, Francisco J Guarda, Alex Faje, Nicholas A Tritos, Karen K Miller, Brooke Swearingen, Lisa B Nachtigall
PURPOSE: To determine the prevalence of IGF-1 normalization with long-term multimodality therapy in a pituitary center, and to assess changes over time. METHODS: Patients with acromegaly (N=409), with >1-year of data after surgery, and at least two subsequent clinic visits, were included in long-term analysis (N=266). Biochemical data, clinical characteristics and therapeutic interventions were reviewed retrospectively. RESULTS: At diagnosis, age was 43...
November 8, 2019: Journal of Clinical Endocrinology and Metabolism
Hadine Joffe, Anouk de Wit, Jamie Coborn, Sybil Crawford, Marlene Freeman, Aleta Wiley, Geena Athappilly, Semmie Kim, Kathryn A Sullivan, Lee S Cohen, Janet E Hall
OBJECTIVE: To determine whether estradiol variability, ovulatory levels of progesterone, and VMS burden are independently associated with perimenopausal depressive symptomatology. DESIGN AND INTERVENTION: Depressive symptoms, serum levels of estradiol and progesterone, and VMS frequency were assessed weekly in an 8-week observational study. Association of mood with estradiol variability, ovulatory levels of progesterone, and VMS frequency were estimated using generalized estimating equation models...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Nam Han Cho, Eu Jeong Ku, Kyoung Yeon Jung, Tae Jung Oh, Soo Heon Kwak, Jae Hoon Moon, Kyong Soo Park, Hak C Jang, Yoon Ji Kim, Sung Hee Choi
CONTEXT: The long-term association between multiple cytokines and progression to diabetes is still uncertain. OBJECTIVE: To identify what cytokines could predict progression to prediabetes and type 2 diabetes over the 10 years. METHODS: The study included 912 participants aged 40 to 69 years at baseline from the Ansung cohort, part of the Korea Genome Epidemiology Study. At baseline, a 75-g oral glucose tolerance test and eight cytokines were measured: plasminogen-activator inhibitor-1 (PAI-1), resistin, interleukin-6, leptin, monocyte-chemoattractant-protein-1, tumor-necrosis-factor-alpha, retinol-binding-protein 4 (RBP4), and adiponectin...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Marco Castellana, Carlo Castellana, Giorgio Treglia, Francesco Giorgino, Luca Giovanella, Gilles Russ, Pierpaolo Trimboli
CONTEXT: Ultrasound (US) risk stratification systems (RSSs) have been developed to reduce the number of unnecessary fine-needle aspiration procedures (FNA) in patients with thyroid nodules. OBJECTIVE: We conducted a systematic review and meta-analysis evaluating the ability of the five most common US RSSs for the appropriate selection of thyroid nodules for FNA. DATA SOURCES: This systematic review and meta-analysis was registered on PROSPERO (CRD42019131771)...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Stergios A Polyzos, Nikolaos Perakakis, Chrysoula Boutari, Jannis Kountouras, Wael Ghaly, Athanasios D Anastasilakis, Asterios Karagiannis, Christos S Mantzoros
AIMS: To investigate circulating levels and liver gene expression of three hormonal pathways associated with obesity, insulin resistance and inflammation to identify leads towards potential diagnostic markers and therapeutic targets in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We compared circulating levels of: a) proglucagon-derived hormones (glucagon-like peptide [GLP]-1, GLP-2, glicentin, oxyntomodulin, glucagon, major proglucagon fragment [MPGF]), b) follistatins-activins (follistatin-like [FSTL]3, activin B), c) IGF axis (insulin-like growth factor [IGF]-1, total and intact IGF binding protein [IGFBP]-3 and IGFBP-4, and pregnancy associated plasma protein [PAPP]-A) in two studies: a) 18 individuals with early stage NAFLD vs...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Stephany H Donze, Veryan Codd, Layla Damen, Wesley J Goedegebuure, Matthew Denniff, Nilesh J Samani, Janiëlle A E M van der Velden, Anita C S Hokken-Koelega
OBJECTIVE: Adults with Prader-Willi syndrome (PWS) are at increased risk of developing age-associated diseases early in life and, like in premature ageing syndromes, ageing might be accelerated. We investigated leukocyte telomere length (LTL), a marker of biological age, in young adults with PWS and compared LTL to healthy young adults of similar age. As all young adults with PWS were treated with growth hormone (GH), we also compared LTL in PWS subjects to GH-treated young adults born short for gestational age (SGA)...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Jiayu Wu, Yaguang Zhao, Xinying Wang, Fang Jiang, Qiao Hou, Dan-Na Chen, Ruizhi Zheng, Renhe Yu, Wei Zhou, Jia-Da Li, Meichao Men
PURPOSE: Idiopathic hypogonadotropic hypogonadism (IHH) and CHARGE syndrome are two distinct developmental disorders sharing features of hypogonadism and/or impaired olfaction. CHD7 variants contribute to >60% CHARGE syndrome and ~10% IHH patients. A variety of extended CHARGE-like features are frequently reported in CHARGE patients harboring CHD7 variants. In this study, we aimed to systematically analyze the diagnostic CHARGE features and the extended CHARGE-like features in IHH patients with CHD7 variants...
November 6, 2019: Journal of Clinical Endocrinology and Metabolism
Gianluca Tornese
No abstract text is available yet for this article.
November 5, 2019: Journal of Clinical Endocrinology and Metabolism
Andrew Dauber
No abstract text is available yet for this article.
November 5, 2019: Journal of Clinical Endocrinology and Metabolism
Eric Göpel, Denise Rockstroh, Heike Pfäffle, Marina Schlicke, Susanne Bechtold-Dalla Pozza, Marie-Hélène Gannagé-Yared, Zoran Gucev, Angelika Mohn, Eva-Maria Harmel, Julia Volkmann, Susann Weihrauch-Blüher, Ruth Gausche, Holger Bogatsch, Christoph Beger, Jürgen Klammt, Roland Pfäffle
CONTEXT: IGF1 receptor mutations (IGF1RM) are rare; however, patients exhibit pronounced growth retardation without catch-up. Although several case reports exist, a comprehensive statistical analysis investigating growth profile and benefit of recombinant growth hormone (rhGH) treatment is still missing. OBJECTIVE AND METHODS: Here, we compared IGF1RM carriers (n = 23) retrospectively regarding birth parameters, growth response to rhGH therapy, near final height and glucose/insulin homeostasis to treated children born small for gestational age (SGA) (n = 34)...
November 4, 2019: Journal of Clinical Endocrinology and Metabolism
Katharina Kessler, Mathias J Gerl, Silke Hornemann, Markus Damm, Christian Klose, Klaus J Petzke, Margrit Kemper, Daniela Weber, Natalia Rudovich, Tilman Grune, Kai Simons, Achim Kramer, Andreas F H Pfeiffer, Olga Pivovarova-Ramich
CONTEXT: Meal timing affects metabolic homeostasis and body weight, but how composition and timing of meals affect plasma lipidomics in humans is not well studied. OBJECTIVE: We used high throughput shotgun plasma lipidomics to investigate effects of timing of carbohydrate and fat intake on lipid metabolism and its relation to glycaemic control. DESIGN: 29 non-diabetic men consumed (i) a high-carb test meal (MTT-HC) at 09:00 and a high-fat meal (MTT-HF) at 15:40; or (ii) MTT-HF at 09:00 and MTT-HC at 15:40...
November 4, 2019: Journal of Clinical Endocrinology and Metabolism
Chao Qiang Jiang, Lin Xu, Tai Hing Lam, Ya Li Jin, Wei Sen Zhang, Feng Zhu, G Neil Thomas, Kar Keung Cheng
CONTEXT: China has the largest number of people with type 2 diabetes mellitus (T2DM) in the world. Data from previous studies suggested that up to one-fifth of individuals with diabetes would be missed without an oral glucose tolerance test (OGTT). To date there is little information on the mortality risk of these individuals. OBJECTIVE: We estimated the association of different indicators of hyperglycaemia with mortality in the general Chinese population. DESIGN: Prospective cohort study...
November 2, 2019: Journal of Clinical Endocrinology and Metabolism
Huaizhu Wu, Lu Xu, Christie M Ballantyne
CONTEXT: The effects of dietary intake of different fatty acids and pharmacological use of fatty acids, specifically long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs), on cardiovascular health and atherosclerotic cardiovascular disease (ASCVD) prevention have been examined in a large number of observational studies and clinical trials. This review summarizes recent data and discusses potential mechanisms. EVIDENCE ACQUISITION: The review is based on the authors' knowledge of the field supplemented by a PubMed search using the terms "seafood," "fish oil," "saturated fatty acids," "omega-3 fatty acids," "eicosapentaenoic acid," "docosahexaenoic acid," "polyunsaturated fatty acids," "monounsaturated fatty acids," and "ASCVD...
November 2, 2019: Journal of Clinical Endocrinology and Metabolism
Sylvie Job, Adrien Georges, Nelly Burnichon, Alexandre Buffet, Laurence Amar, Jérôme Bertherat, Nabila Bouatia-Naji, Aurélien de Reyniès, Delphine Drui, Charlotte Lussey-Lepoutre, Judith Favier, Anne-Paule Gimenez-Roqueplo, Luis Jaime Castro-Vega
CONTEXT: Pheochromocytomas and paragangliomas (PPGL) are neuroendocrine tumors explained by germline or somatic mutations in about 70% of cases. Patients with SDHB mutations are at high risk of developing metastatic disease, yet no reliable tumor biomarkers are available to predict tumor aggressiveness. OBJECTIVE: We aimed at identifying long non-coding RNAs (lncRNAs) specific for PPGL molecular groups and metastatic progression. DESIGN AND METHODS: To analyse the expression of lncRNAs, we used a mining approach of transcriptome data from a well-characterized series of 187 tumor tissues...
November 2, 2019: Journal of Clinical Endocrinology and Metabolism
Yang Zhang, Weijie Sun, Sainan Zhu, Youyuan Huang, Yu Huang, Ying Gao, Junqing Zhang, Huixia Yang, Xiaohui Guo
CONTEXT: The impact of mild TSH elevation (2.5-4.08 mIU/L) on pregnancy outcomes is unclear. The treatment strategy for mild TSH elevation is dependent on TPOAb status according to the guidelines. OBJECTIVE: To assess the effects of mild thyroid dysfunction combined with TPOAb status in the 1st trimester on pregnancy outcomes and the impact of L-T4 treatment on pregnancy outcomes. DESIGN: The study retrospectively evaluated 3562 pregnant women...
November 2, 2019: Journal of Clinical Endocrinology and Metabolism
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