journal
Journals Journal of Clinical Endocrinol...

Journal of Clinical Endocrinology and Metabolism

https://read.qxmd.com/read/33462622/iron-overload-in-functional-hyperandrogenism-in-a-randomized-trial-bloodletting-does-not-improve-metabolic-outcomes
#1
Andrés E Ortiz-Flores, María Ángeles Martínez-García, Lía Nattero-Chávez, Francisco Álvarez-Blasco, Elena Fernández-Durán, Alejandra Quintero-Tobar, Héctor F Escobar-Morreale, Manuel Luque-Ramírez
CONTEXT: Functional hyperandrogenism may be associated with a mild increase in body iron stores. Iron depletion exerts a beneficial effect on metabolic endpoints in other iron overload states. OBJECTIVES: (i) To determine the effect of iron depletion on the insulin sensitivity and frequency of abnormal glucose tolerance in patients with functional hyperandrogenism submitted to standard therapy with combined oral contraceptives (COC). ii) To assess the overall safety of this intervention...
January 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33462619/insulin-like-growth-factor-1-bone-mineral-density-and-fracture-a-mendelian-randomization-study
#2
Shuai Yuan, Zi-Hao Wan, Shi-Le Cheng, Karl Michaëlsson, Susanna C Larsson
CONTEXT: The associations of circulating insulin-like growth factor-1 (IGF-1) levels with bone mineral density and fracture risk are inconclusive in observational studies. OBJECTIVE: We conducted a mendelian randomization study to assess the associations of serum IGF-1 levels with estimated bone mineral density (eBMD) and fracture. METHODS: Genetic instruments for IGF-1 were selected at the genome-wide significance level (P < 5 × 10-8) from a genome-wide association study including 358 072 individuals of European ancestry...
January 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33462615/paraneoplastic-secretion-of-multiple-phosphatonins-from-a-deep-fibrous-histiocytoma-causing-oncogenic-osteomalacia
#3
Melvin Khee Shing Leow, Shaillay Dogra, Xiaojia Ge, Khoon Leong Chuah, Huiling Liew, Kelvin Siu Hoong Loke, Craig McFarlane
CONTEXT: Literature suggests that oncogenic osteomalacia is usually caused by a benign mesenchymal tumor secreting fibroblast growth factor subtype-23 (FGF-23), but the involvement of other phosphatonins has only been scarcely reported. We have previously published a seemingly typical case of oncogenic osteomalacia. Following curative neoplasm resection, we now report unique molecular characteristics and biology of this tumor. CASE DESCRIPTION: A 25-year-old man had been diagnosed with severe oncogenic osteomalacia that gradually crippled him over 6 years...
January 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33462612/exocrine-pancreatic-function-modulates-plasma-metabolites-through-changes-in-gut-microbiota-composition
#4
Maik Pietzner, Kathrin Budde, Malte Rühlemann, Henry Völzke, Georg Homuth, Frank U Weiss, Markus M Lerch, Fabian Frost
PURPOSE: Exocrine pancreatic function is critically involved in regulating the gut microbiota composition. At the same time, its impairment acutely affects human metabolism. How these 2 roles are connected is unknown. We studied how the exocrine pancreas contributes to metabolism via modulation of gut microbiota. DESIGN: Fecal samples were collected in 2226 participants of the population-based Study of Health in Pomerania (SHIP/SHIP-TREND) to determine exocrine pancreatic function (pancreatic elastase enzyme-linked immunosorbent assay) and intestinal microbiota profiles (16S ribosomal ribonucleic acid gene sequencing)...
January 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33462603/metastatic-pheochromocytomas-and-abdominal-paragangliomas
#5
Dan Granberg, Carl Christofer Juhlin, Henrik Falhammar
CONTEXT: Pheochromocytomas and paragangliomas (PPGLs) are believed to harbor malignant potential; about 10% to 15% of pheochromocytomas and up to 50% of abdominal paragangliomas will exhibit metastatic behavior. EVIDENCE ACQUISITION: Extensive searches in the PubMed database with various combinations of the key words pheochromocytoma, paraganglioma, metastatic, malignant, diagnosis, pathology, genetic, and treatment were the basis for the present review. DATA SYNTHESIS: To pinpoint metastatic potential in PPGLs is difficult, but nevertheless crucial for the individual patient to receive tailor-made follow-up and adjuvant treatment following primary surgery...
January 19, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33460435/prevalence-and-spectrum-of-dicer1-mutations-in-adult-onset-thyroid-nodules-with-indeterminate-cytology
#6
Anne-Sophie Chong, Yuri E Nikiforov, Vincenzo Condello, Abigail I Wald, Marina N Nikiforova, William D Foulkes, Barbara Rivera
CONTEXT: DICER1 mutations are found in multinodular goiter and differentiated thyroid carcinoma in children, and can be a manifestation of DICER1 syndrome, but the prevalence of DICER1 mutations and their significance in adult-onset thyroid nodules is unknown. OBJECTIVE: Determine 1) the prevalence of DICER1 hotspot mutations in thyroid nodules; 2) the frequency of a second DICER1 pathogenic variant in thyroid nodules with DICER1 hotspot mutations; 3) the prevalence of other thyroid cancer driver mutations in thyroid nodules with and without DICER1 hotspot mutations...
January 18, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33449080/stuttering-and-incident-type-2-diabetes-a-population-based-study-of-2-2-million-adolescents
#7
Avishai M Tsur, Shir Hershkovich, Inbar Zucker, Miri Lutski, Orit Pinhas-Hamiel, Asaf Vivante, Maya Fischman, Ofer Amir, Jacob Rotchild, Hertzel C Gerstein, Tali Cukierman-Yaffe, Limor Friedensohn, Ofri Mosenzon, Estela Derazne, Dorit Tzur, Amir Tirosh, Arnon Afek, Itamar Raz, Gilad Twig
PURPOSE: To investigate the association between stuttering in adolescence and incident type 2 diabetes in young adulthood. MATERIALS AND METHODS: This nationwide population-based study included 2,193,855 adolescents of age 16-20 years who were assessed for military service between 1980 and 2013. Diagnoses of stuttering in adolescence were confirmed by a speech-language pathologist. Diabetes status for each individual as of December 31, 2016, was determined by linkage to the Israeli National Diabetes Registry...
January 15, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33440005/corrigendum-to-osteoporosis-in-premenopausal-women-a-clinical-narrative-review-by-the-ects-and-the-iof
#8
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33440004/corrigendum-to-safety-of-high-dose-vitamin-d-supplementation-secondary-analysis-of-a-randomized-controlled-trial
#9
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33438719/erratum-for-classic-and-nonclassic-apparent-mineralocorticoid-excess-syndrome
#10
(no author information available yet)
No abstract text is available yet for this article.
January 13, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33433590/addressing-insulin-access-and-affordability-an-endocrine-society-position-statement
#11
(no author information available yet)
Rising costs have made access to affordable insulin far more difficult for people with diabetes, especially low-income individuals, those on high deductible health plans, beneficiaries using Medicare Part B to cover insulin delivered via pump, Medicare beneficiaries in the Part D donut hole, and those who turn 26 and must transition from their parents' insurance, to manage their diabetes and avoid unnecessary complications and hospitalizations. For many patients with diabetes, insulin is a life-saving medication...
January 12, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33432973/letter-to-the-editor-from-dalan-vitamin-d-supplementation-for-prevention-of-type-2-diabetes-mellitus-to-d-or-not-to-d
#12
Rinkoo Dalan
No abstract text is available yet for this article.
January 12, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33428730/novel-recurrent-altered-genes-in-chinese-patients-with-anaplastic-thyroid-cancer
#13
Lingyun Zhang, Zhixiang Ren, Zhengzheng Su, Yang Liu, Tian Yang, Minyuan Cao, Yong Jiang, Ying Tang, Haining Chen, Weihan Zhang, Rixiang Gong, Tao Wei, Yong Peng, Bo Liu, Wei Zhang, Li Yang, Yiguo Hu, Zhihui Li, Jingqiang Zhu, Heng Xu, Yang Shu, Han Luo
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare but lethal malignancy, and few systematic investigations on genomic profiles of ATC was performed in Chinese patients. METHODS: Fifty-four ATC patients in West China Hospital between 2010 to 2020 were retrospectively analyzed, while 29 patients with available samples were sequenced by whole-exome sequencing (WES). The associations between genomic alterations and clinical characteristics were statistically evaluated...
January 11, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33421070/insulin-resistance-in-congenital-adrenal-hyperplasia-is-compensated-for-by-reduced-insulin-clearance
#14
Daniel Minutti de Oliveira, Andrea Tura, Ana Carolina Junqueira Vasques, Daniella Fernandes Camilo, Marcelo Miranda Lima, Sofia Helena Valente de Lemos-Marini, Ezequiel Moreira Goncalves, Gil Guerra-Junior, Bruno Geloneze
CONTEXT: Congenital Adrenal Hyperplasia (CAH) patients have potential normal longevity. However, a greater risk for cardiovascular disease has been reported. Insulin resistance and hyperinsulinemia have been described in CAH patients, whereas the prevalence of overt type 2 diabetes is not higher in CAH than in normal population. OBJECTIVE: To examine the contributions of insulin secretion and of hepatic insulin clearance to compensatory hyperinsulinemia in young insulin resistant adults with classic CAH due to 21-hydroxylase deficiency (21-OHD)...
January 9, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33421066/pitfalls-in-performing-and-interpreting-inferior-petrosal-sinus-sampling-personal-experience-and-literature-review
#15
Jordan E Perlman, Philip C Johnston, Ferdinand Hui, Guy Mulligan, Robert J Weil, Pablo F Recinos, Divya Yogi-Morren, Roberto Salvatori, Debraj Mukherjee, Gary Gallia, Laurence Kennedy, Amir H Hamrahian
CONTEXT: Inferior petrosal sinus sampling (IPSS) helps differentiate the source of ACTH-dependent hypercortisolism in patients with inconclusive biochemical testing and imaging, and is considered the gold standard for distinguishing Cushing disease (CD) from ectopic ACTH syndrome (EAC). We present a comprehensive approach to interpreting IPSS results by examining several real cases. EVIDENCE ACQUISITION: We performed a comprehensive review of the IPSS literature using PubMed since it was first described in 1977...
January 9, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33421062/corrigendum-to-effects-of-levothyroxine-on-pregnant-women-with-subclinical-hypothyroidism-negative-for-thyroid-peroxidase-antibodies
#16
(no author information available yet)
No abstract text is available yet for this article.
January 9, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33420793/plasma-lipidomic-profiles-and-risk-of-diabetes-two-prospective-cohorts-of-hiv-infected-and-hiv-uninfected-individuals
#17
Eric Zhang, Jin Choul Chai, Amy A Deik, Simin Hua, Anjali Sharma, Michael F Schneider, Deborah Gustafson, David B Hanna, Jordan E Lake, Leah H Rubin, Wendy S Post, Kathryn Anastos, Todd Brown, Clary B Clish, Robert C Kaplan, Qibin Qi
OBJECTIVES: Antiretroviral therapy (ART) use is associated with disrupted lipid and glucose metabolism in people with HIV-infection. We aimed to identify plasma lipid species associated with risk of diabetes in the context of HIV infection. RESEARCH DESIGN AND METHODS: We profiled 211 plasma lipid species in 491 HIV-infected and 203 HIV-uninfected participants aged 35-55 years from the Women's Interagency HIV study and the Multicenter AIDS Cohort Study. Cox proportional hazards model was used to examine associations between baseline lipid species and incident diabetes (166 diabetes cases were identified during a median follow-up of 12...
January 9, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33420791/association-between-obstructive-sleep-apnea-and-metabolic-abnormalities-in-patients-with-hypertrophic-cardiomyopathy
#18
Juan Wang, Haobo Xu, Jiansong Yuan, Chao Guo, Fenghuan Hu, Weixian Yang, Lei Song, Xiaoliang Luo, Rong Liu, Jingang Cui, Shengwen Liu, Yushi Chun, Shubin Qiao
OBJECTIVES: Metabolic abnormalities have been associated with long-term cardiac mortality in patients with hypertrophic cardiomyopathy (HCM). Obstructive sleep apnea (OSA) is a risk factor for metabolic abnormalities in general populations, but association between OSA and metabolic abnormalities in HCM is still undefined. This study aimed to investigate the relationship between OSA and metabolic dysfunction in a large series of patients with HCM. METHODS: A total of 587 patients with HCM who underwent sleep evaluations at Fuwai Hospital were included...
January 9, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33417714/body-habitus-across-the-lifespan-and-risk-of-pituitary-adenoma
#19
David J Cote, Timothy R Smith, Ursula B Kaiser, Edward R Laws, Meir J Stampfer
CONTEXT: No studies have examined the association between body habitus and incidence of pituitary adenoma. OBJECTIVE: To determine if body mass index (BMI), waist circumference, body somatotype, or height are associated with risk of pituitary adenoma. DESIGN: Pooled analysis of three prospective cohort studies. SETTING: Population-based study. PARTICIPANTS: Participants of the NHS, NHSII, and HPFS, totaling 284,946 American health professionals...
January 8, 2021: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/33417713/generation-of-%C3%AE-cells-from-ipsc-of-a-mody8-patient-with-a-novel-mutation-in-the-carboxyl-ester-lipase-cel-gene
#20
Silvia Pellegrini, Giovanni B Pipitone, Alessandro Cospito, Fabio Manenti, Gaia Poggi, Marta T Lombardo, Rita Nano, Gianvito Martino, Maurizio Ferrari, Paola Carrera, Valeria Sordi, Lorenzo Piemonti
CONTEXT: MODY8 is a rare form of monogenic diabetes characterized by a mutation in CEL (carboxyl-ester-lipase) gene, which leads to exocrine pancreas dysfunction, followed by β cell failure. Induced pluripotent stem cells can differentiate into functional β cells. Thus, β cells from MODY8 patients can be generated in vitro and used for disease modelling and cell replacement therapy. DESIGN AND RESULTS: A genetic study was performed in a patient suspected of monogenic diabetes...
January 8, 2021: Journal of Clinical Endocrinology and Metabolism
journal
journal
20145
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"