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Journals Journal of Clinical Endocrinol...

Journal of Clinical Endocrinology and Metabolism

https://read.qxmd.com/read/38753865/prostate-risk-and-monitoring-during-testosterone-replacement-therapy
#21
JOURNAL ARTICLE
Shalender Bhasin, Ian M Thompson
Men with hypogonadism have reduced risk of prostate cancer mortality; whether testosterone treatment increases the risk of prostate safety events in men with hypogonadism remains controversial. Several studies including four larger randomized trials-the Testosterone Trials, TEstosterone and Atherosclerosis Progression in Aging Men (TEAAM) Trial, Testosterone for Diabetes Mellitus Trial, and Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE in hypogonadal men (TRAVERSE) Trial-treated men with testosterone or placebo for one year or longer and reported prospectively-ascertained prostate safety data...
May 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38753668/environmental-phenols-and-growth-in-infancy-the-infant-feeding-and-early-development-study
#22
JOURNAL ARTICLE
Danielle R Stevens, Mandy Goldberg, Margaret Adgent, Helen B Chin, Donna D Baird, Virginia A Stallings, Dale P Sandler, Antonia M Calafat, Eileen G Ford, Babette S Zemel, Andrea Kelly, David M Umbach, Walter Rogan, Kelly K Ferguson
CONTEXT: Higher mean and rapid increases in body mass index (BMI) during infancy are associated with subsequent obesity and may be influenced by exposure to endocrine-disrupting chemicals such as phenols. OBJECTIVE: In a prospective US-based cohort conducted 2010-2014, we investigated associations between environmental phenol exposures and BMI in 199 infants. METHODS: We measured seven urinary phenols at ages 6-8 and 12 weeks and assessed BMI z-score at up to 12 study visits between birth and 36 weeks...
May 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38753423/clustering-identifies-subtypes-with-different-phenotypic-characteristics-in-women-with-polycystic-ovary-syndrome
#23
JOURNAL ARTICLE
Kim van der Ham, Loes M E Moolhuijsen, Kelly Brewer, Ryan Sisk, Andrea Dunaif, Joop S E Laven, Yvonne V Louwers, Jenny A Visser
CONTEXT: Hierarchical clustering (HC) identifies subtypes of polycystic ovary syndrome (PCOS). OBJECTIVE: This work aimed to identify clinically significant subtypes in a PCOS cohort diagnosed with the Rotterdam criteria and to further characterize the distinct subtypes. METHODS: Clustering was performed using the variables body mass index (BMI), luteinizing hormone (LH), follicle-stimulating hormone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), testosterone, insulin, and glucose...
May 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38752390/papp-a-as-a-potential-target-in-thyroid-eye-disease
#24
JOURNAL ARTICLE
Cheryl A Conover, Laurie K Bale, Marius N Stan
CONTEXT: Proptosis in Thyroid Eye Disease (TED) can result in facial disfigurement and visual dysfunction. Treatment with Insulin-like growth factor I receptor (IGF-IR) inhibitors has been shown to be effective in reducing proptosis but with side effects. OBJECTIVE: To test the hypothesis that inhibition of IGF-IR indirectly and more selectively with PAPP-A inhibitors attenuates IGF-IR signaling in TED. DESIGN: Informed consent was obtained from TED patients undergoing surgery, and retro-orbital tissue collected for fibroblast isolation and culture...
May 16, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38748681/normative-data-for-insulin-like-growth-factor-1-igf-1-in-healthy-children-and-adolescents-from-india
#25
JOURNAL ARTICLE
Kasagani Venkata Ravi Teja, Bhanu Malhotra, Mandy Vogel, Raman Kumar Marwaha, Arun Aggarwal, Rimesh Pal, Liza Das, Naresh Sachdeva, Nagita Devi, Dipika Bansal, Ashu Rastogi, Sadhna Sharma, Dewan Gajinder, Sanjay Kumar Bhadada, Jayaditya Ghosh, Phillip J Monaghan, Márta Korbonits, Pinaki Dutta
BACKGROUND: Serum IGF-1 is an important biochemical tool to diagnose and monitor GH-related disorders. However, ethnic-specific Indian data following consensus criteria for the establishment of normative data, are not available. Our objective was to generate chronological age (CA)-, bone age (BA)- and Tanner stage-specific normative data for IGF-1 in healthy Indian children and adolescents. METHODS: A cross-sectional epidemiological study was conducted in schools and the community, which enrolled apparently healthy children and adolescents with robust exclusion criteria...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38748619/synergy-of-nodal-factors-in-predicting-recurrence-after-treatment-of-n1b-papillary-thyroid-carcinoma
#26
JOURNAL ARTICLE
Keyao Xian, Siyuan Xu, Hui Huang, Chengwei Xing, Xiaolei Wang, Shaoyan Liu, Jie Liu
BACKGROUND: Nodal factors are important predictors of prognosis for papillary thyroid carcinoma (PTC), but their synergy effect is not well understood. We aimed to explore their synergy effect in predicting recurrence of clinical N1b PTC. METHODS: Patients who underwent surgery for cN1b PTC from 2013 to 2017 were enrolled. The association between nodal factors and recurrence was assessed using Cox proportional hazards regression models. Interaction and stratified analyses were conducted according to significant nodal factors...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38747483/controlled-antenatal-thyroid-screening-study-iii-effects-of-gestational-thyroid-status-on-adolescent-brain-morphology
#27
JOURNAL ARTICLE
Anna Scholz, Carolyn B McNabb, Laura Bloomfield, Raghav Bhargava, Charlotte Hales, Colin M Dayan, Peter N Taylor, John H Lazarus, Onyebuchi Okosieme, Marian Ludgate, Derek K Jones, D Aled Rees
CONTEXT: Children born to mothers with gestational hypo- or hyperthyroidism may have increased risk of adverse neurodevelopmental outcomes. However, the effects of maternal thyroid status on offspring brain development are unclear. OBJECTIVE: To establish whether adolescent brain morphology is affected by suboptimal gestational thyroid function (SGTF). DESIGN AND SETTING: The Controlled Antenatal Thyroid Screening (CATS) study randomized mothers with SGTF to levothyroxine or no supplementation from ∼12 weeks' gestation...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38747476/defining-overweight-and-obesity-by-percent-body-fat-instead-of-body-mass-index
#28
JOURNAL ARTICLE
Adam W Potter, Geoffrey C Chin, David P Looney, Karl E Friedl
OBJECTIVE: Thresholds for overweight and obesity are currently defined by body mass index (BMI), a poor surrogate marker of actual adiposity (percent body fat, %BF). Practical modern technologies provide estimates of %BF but medical providers need outcome-based %BF thresholds to guide patients. This analysis determines %BF thresholds based on key obesity-related comorbidities, exhibited as metabolic syndrome (MetSyn). These limits were compared to existing BMI thresholds of overweight and obesity...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38747471/associations-of-vegetable-and-potato-intakes-with-markers-of-type-2-diabetes-risk-in-the-ausdiab-cohort
#29
JOURNAL ARTICLE
Pratik Pokharel, Lauren C Blekkenhorst, Catherine P Bondonno, Kevin Murray, Simone Radavelli-Bagatini, Dianna J Magliano, Robin M Daly, Jonathan E Shaw, Joshua R Lewis, Jonathan M Hodgson, Nicola P Bondonno
CONTEXT: The associations of vegetable and potato intakes with type 2 diabetes (T2D) appear to be nuanced, depending on vegetable types and preparation method, respectively. OBJECTIVE: We investigated the associations of total vegetable, vegetable subgroup, and potato intakes with 1) markers of T2D at baseline and 2) incident T2D cumulative over a 12-year follow-up period in Australian adults. METHODS: Using data from the Australian Diabetes, Obesity and Lifestyle Study, intakes of vegetables and potatoes were assessed via a food frequency questionnaire at baseline...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38747468/assessing-lateralization-index-of-adrenal-venous-sampling-for-surgical-indication-in-primary-aldosteronism
#30
JOURNAL ARTICLE
Hiroki Kobayashi, Yoshihiro Nakamura, Masanori Abe, Oskar Ragnarsson, Eleftheria Gkaniatsa, Marianne Aa Grytaas, Kristian Løvås, Norio Wada, Takamasa Ichijo, Daniel A Heinrich, William Drake, Sam O'Toole, Tomaz Kocjan, Darko Kastelan, Ivana Kraljevic, Koichi Yamamoto, Mika Tsuiki, Simon Kloock, Ulrich Dischinger, Mirko Parasiliti-Caprino, Gruber Sven, Ariadni Spyroglou, Raluca Maria Furnica, Francesco Fallo, Giuseppe Maiolino, Mitsuhiro Kometani, Vin-Cent Wu, Felix Beuschlein, Martin Reincke, Mitsuhide Naruse
BACKGROUND: Clinical practice guidelines recommend the Lateralization Index (LI) as the standard for determining surgical eligibility in primary aldosteronism (PA). Our goal was to identify the optimal LI cut-offs in adrenal venous sampling (AVS) for diagnosing PA that is amenable to surgical cure. METHODS: We conducted a retrospective international cohort study across 16 institutions in 11 countries, including 1,550 patients with PA who underwent AVS, with and/or without ACTH stimulation...
May 15, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38742619/letter-to-the-editor-from-ho-and-melmed-clinical-practice-and-nomenclature-of-pituitary-neoplasms-common-sense-must-prevail
#31
JOURNAL ARTICLE
Ken K Y Ho, Shlomo Melmed
No abstract text is available yet for this article.
May 14, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38742613/response-to-letter-to-the-editor-from-de-zegher-and-ib%C3%A3-%C3%A3-ez-metformin-and-combined-oral-contraceptive-pills-in-the-management-of-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#32
JOURNAL ARTICLE
Johanna Melin, Maria Forslund, Simon Alesi, Terhi Piltonen, Daniela Romualdi, Poli Mara Spritzer, Chau Thien Tay, Alexia Pena, Selma Feldman Witchel, Helena Teede, Aya Mousa
No abstract text is available yet for this article.
May 14, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739762/skeletal-impact-of-parathyroidectomy-on-patients-with-primary-hyperparathyroidism-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Nattanan Kongsaree, Thanaporn Thanyajaroen, Bothamai Dechates, Phonthip Therawit, Wiriya Mahikul, Kanchana Ngaosuwan
CONTEXT: Parathyroidectomy is recommended for curing primary hyperparathyroidism (PHPT), although uncertainty remains regarding the extent of fracture risk reduction following surgery. OBJECTIVE: To compare fracture risk and bone mineral density (BMD) changes in patients with PHPT undergoing parathyroidectomy (PTX) versus observation (OBS). DATA SOURCES: We systematically searched PubMed, Embase, and the Cochrane Library until September 2022, including randomized controlled trials (RCTs) and cohort studies, and reviewed citations from previous reviews...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739756/contrasting-bone-profiles-in-pcos-are-related-to-bmi-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Graziela Rissetti, Julia Mottecy Piovezan, Melissa Orlandin Premaor, Fabio Vasconcellos Comim
CONTEXT: Controversial results have emerged regarding whether PCOS is protective or increases the risk of bone frailty. OBJECTIVE: This study investigated whether the PCOS condition affects bone parameters of premenopausal women. This is an update for a previous meta-analysis published in 2019. DATA SOURCES: We searched MEDLINE and Embase. STUDY SELECTION: Studies were considered eligible for the update if published in English between the 1st of October 2018 and the 31st of December 2023...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739731/titration-of-sedentary-behavior-with-varying-physical-activity-levels-reduces-mortality-in-patients-with-type-2-diabetes
#35
JOURNAL ARTICLE
Jieyi Liu, Chenzhi Ai, Zhihong Li, Xiaoxia Huang, Mengjia Shen, Cankun Zheng, Wangjun Liao, Jianping Bin, Jinghua Li, Hairuo Lin, Ziyun Guan, Yulin Liao
CONTEXT: Both physical activity (PA) and sedentary behavior (SB) exert important impact on type 2 diabetes, but it remains unclear how maximum impact on improving the mortality and optimized proportion of the two lifestyles combination exists. OBJECTIVE: To explore the impacts of PA/SB combinations on mortality in patients with diabetes. METHODS: Patients with type 2 diabetes patients samplings were collected from the National Health and Nutrition Examination Survey (NHANES) dataset...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739548/estimation-of-glucose-absorption-insulin-sensitivity-and-glucose-effectiveness-from-the-oral-glucose-tolerance-test
#36
JOURNAL ARTICLE
Darko Stefanovski, Dawn D Smiley, Naresh M Punjabi, Guillermo E Umpierrez, Priyathama Vellanki
CONTEXT: Glucose tolerance during an oral glucose tolerance test (OGTT) is affected by variations in glucose effectiveness (GE) and glucose absorption and thus affects minimal model calculations of insulin sensitivity (SI). The widely used OGTT SI by Dalla Man et al. does not account for variances in GE and glucose absorption. OBJECTIVE: To develop a novel model that concurrently assesses SI, GE, and glucose absorption. DESIGN: Cross-sectional...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739542/immune-checkpoint-molecules-in-adrenocortical-carcinoma-hope-for-immunotherapy
#37
EDITORIAL
Enzo Lalli
No abstract text is available yet for this article.
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38739541/high-amh-levels-are-associated-with-gestational-hypertension-in-patients-with-pcos-who-underwent-ivf-icsi-et
#38
JOURNAL ARTICLE
Menghui Zhang, Shujun Liu, Fuli Zhang, Hao Shi, Fang Wang, Caihong Chen, Qingling Yang, Shanjun Dai, Yuling Liang, Yihong Guo
BACKGROUND: Patients with polycystic ovary syndrome (PCOS) have a higher risk of obstetric complications. The association between anti-Müllerian hormone (AMH) and gestational hypertension in these patients is poorly understood. OBJECTIVE: To determine the association between serum AMH levels and gestational hypertension in patients with PCOS undergoing fresh embryo transfer. METHODS: This retrospective study included 649 patients with PCOS who had singleton live births after undergoing fresh embryo transfers...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38738690/correction-to-vitamin-d-status-vitamin-d-receptor-polymorphisms-and-risk-of-type-2-diabetes-a-prospective-cohort-study
#39
(no author information available yet)
No abstract text is available yet for this article.
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38735658/coexisting-ret-ptc-and-tert-promoter-mutation-predict-poor-prognosis-but-effective-ret-and-mek-targets-in-thyroid-cancer
#40
JOURNAL ARTICLE
Wei Zhang, Shuhuang Lin, Zhuo Wang, Wenyong Zhang, Mingzhao Xing
PURPOSE: To investigate the role of coexisting RET/PTC rearrangement and TERT promoter mutation in the prognosis and therapeutic targeting in papillary thyroid cancer (PTC). METHODS: A total of 669 PTC patients with complete clinical follow-up and genetic data were pooled from thyroid cancer datasets TCGA, MSK MetTropism, and MSK-IMPACT, from whom 163 patients (112 women and 47 men, 4 unknown) with wild-type BRAF/RAS were identified, with median age (IQR) of 46...
May 13, 2024: Journal of Clinical Endocrinology and Metabolism
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