Fertility and Sterility

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Currently, the mainstay for treating endometriosis/adenomyosis consists in hormonal drugs. Aside from staying within the "therapeutic window" and cutting off the hormonal support to the ectopic endometrium, none of these treatments were developed with a pre-identified target. The current lack of innovation is humbling, especially considering that among over 34,000 PubMed-indexed publications on endometriosis or adenomyosis, ∼65% of them were published in the last two decades, many of them presumably with all the benefits of omics and molecular biology...

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Confounding variables represent one of the most important considerations for researchers and readers of scientific clinical papers.

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We performed a comprehensive narrative synthesis of systematic reviews with meta-analysis published in the last five years on the association of endometriosis and adenomyosis with reproductive and obstetric outcomes. The aim was defining the information on which to base preconceptional counselling and clarifying whether and in which cases pregnant women with endometriosis and adenomyosis should be referred to tertiary care centers and followed as high-risk obstetric patients. Reduced pregnancy and live birth rates, and an increased miscarriage rate were observed in women with endometriosis and adenomyosis...

OBJECTIVE: To evaluate the attachment rate of a human embryonic stem cell-derived trophoblastic spheroid (BAP-EB) onto endometrial epithelial cells in predicting the cumulative live birth rate of an in vitro fertilization (IVF) cycle DESIGN: Prospective observational study SUBJECTS: 240 infertile women from 2017 to 2021. INTERVENTION (FOR RCT) OR EXPOSURE (FOR OBSERVATIONAL STUDIES): Infertile women with regular cycles attending for IVF were recruited. An endometrial aspirate was collected from a natural cycle one month before IVF to determine the BAP-EB attachment rate...

IMPORTANCE: There is a lack of consensus and reliable evidence regarding the impact of re-cryopreservation technique on human embryos, particularly with respect to embryo viability and in vitro fertilization (IVF) outcomes. OBJECTIVE: To investigate the impact of re-cryopreservation on embryo viability and IVF outcomes by comparing to single cryopreservation. DATA SOURCES: Databases PubMed, Embase, Cochrane Library and Scopus were searched until 10 October 2022...

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Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are extremely similar. Both tissues originate from eutopically located intracavitary endometrium. Oligoclones of endometrial glandular epithelial cells with somatic mutations and attached stromal cells may give rise to endometriosis if they travel to peritoneal surfaces or the ovary via retrograde menstruation and/or may be entrapped in myometrium to give rise to adenomyosis. In both instances, the endometrial cells populations possess survival and growth capabilities conferred by somatic epithelial mutations and epigenetic abnormalities in stromal cells...

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A narrative review on endometrial receptivity in adenomyosis and/or endometriosis reveals that this parameter is difficult to assess in natural conception, as both disorders alter natural fertility. Recent data emanating from ART have allowed to study endometrial receptivity in women affected by adenomyosis and endometriosis. This has upended our views on the effects of these two disorders on embryo implantation. Today, the very existence of altered receptivity in ART is questioned. In this context, we now know that frozen euploid blastocyst transfers in E2 and progesterone cycles have unaltered outcome in case of both adenomyosis and endometriosis...