Serdar E Bulun, Sule Yildiz, Mazhar Adli, Debabrata Chakravarti, James Brandon Parker, Magdy Milad, Linda Yang, Angela Chaudhari, Susan Tsai, Jian Jun Wei, Ping Yin
Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are extremely similar. Both tissues originate from eutopically located intracavitary endometrium. Oligoclones of endometrial glandular epithelial cells with somatic mutations and attached stromal cells may give rise to endometriosis if they travel to peritoneal surfaces or the ovary via retrograde menstruation and/or may be entrapped in myometrium to give rise to adenomyosis. In both instances, the endometrial cells populations possess survival and growth capabilities conferred by somatic epithelial mutations and epigenetic abnormalities in stromal cells...
March 14, 2023: Fertility and Sterility