Fertility and Sterility

The technological necessity that has driven the field of ovarian tissue cryopreservation arose from the urgency of saving the reproductive potential of children with cancer facing gonadotoxic therapies. The field has expanded rapidly, with many centers offering this service, yet there are few outcomes reported because of the time lag between tissue freezing and its utilization. Questions about the best practices for patient selection, the best techniques for freezing and thawing, and the large loss of oocytes that accompanies the freezing and thawing process remain...

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No abstract text is available yet for this article.

OBJECTIVE: To understand how the Donor Conception Identity Questionnaire (DCIQ) correlates with mental health and explore differences on the DCIQ between donor conceived people who were actively searching for donor connections to those who were not and those who had found their donor connections to those who had not. DESIGN: Cross sectional survey. SUBJECTS: 88 donor conceived adults ranging in age from 18 to 70 (Mean = 34.27 years, median = 31 years)...

Birth rates continue to decline as more women experience fertility issues. Assisted reproductive technologies are available for patients seeking fertility treatment, including cryopreservation techniques. Cryopreservation can be performed on gametes, embryos, or gonadal tissue and can be used for patients who desire to delay in vitro fertilization treatment. This review focuses on ovarian tissue cryopreservation, the freezing of ovarian cortex containing immature follicles. Ovarian tissue cryopreservation is the only available treatment for the restoration of ovarian function in patients who undergo gonadotoxic treatments, and its wide adoption has led to its recent designation as "no longer experimental" by the American Society for Reproductive Medicine...

OBJECTIVE: Evaluate associations between preconception 25-hydroxyvitamin D (25(OH)D) and biomarkers in female and male partners on live birth, pregnancy loss, and semen quality. DESIGN AND SUBJECTS: Secondary analysis using the FAZST trial of couples seeking infertility treatment at 4 US centers (2013-2017). A target trial emulation framework was applied to estimate associations. Couples were followed for nine months or through pregnancy. EXPOSURES: Preconception concentrations of 25(OH)D (primary) and associated biomarkers: vitamin D binding protein (VDBP), calcium, free vitamin D, bioavailable vitamin D...

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OBJECTIVE: To examine the association between preovulation body mass index and pregnancy outcomes after frozen embryo transfer in patients with polycystic ovary syndrome with insulin resistance. DESIGN: This was a single-center, retrospective cohort study. SUBJECTS: Women with infertility, diagnosed with polycystic ovary syndrome and insulin resistance, and treated at the Reproductive Medicine Center, Second People's Hospital of Nanning, China, between January 2020 and August 2023, were included...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

IMPORTANCE: PGT-A to deselect aneuploid embryos in ART cycles may hold promise by augmenting pregnancy rates per transfer and reducing pregnancy loss rates for patients with unexplained recurrent pregnancy loss. OBJECTIVE: To explore effectiveness of PGT-A in managing unexplained recurrent pregnancy loss by evaluating several key aspects: (i) the likelihood of a live birth in a subsequent spontaneous pregnancy, (ii) whether women with unexplained recurrent pregnancy loss have higher rate of aneuploidy, (iii) whether euploid blastocysts offer comparable live birth rate in patients with unexplained recurrent pregnancy loss, (iv) whether the endometrium is less selective in unexplained recurrent pregnancy loss, and (v) whether PGT-A increases live birth rate or reduces pregnancy losses until delivery...

OBJECTIVE: To determine whether we can safely and successfully transplant an ovary tissue allograft from a non-identical donor to her Turner syndrome sister. DESIGN: Transplantation of cryopreserved ovary tissue, as well as fresh transplantation of ovarian tissue between identical twins, is now well established with numerous reported successful cases. However there have not yet been any ovary transplants between non-identical women requiring immunosuppression (ovary allotransplant)...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

No abstract text is available yet for this article.

OBJECTIVE: To evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on first transfer live birth rate (LBR) and cumulative LBR (CLBR) in donor oocyte IVF cycles. DESIGN: Retrospective cohort study of the SART CORS database. SUBJECTS: 11,348 fresh and 7,214 frozen-thawed donor oocyte IVF cycles were analyzed. EXPOSURE: The first reported donor stimulation cycle per patient between January 1, 2014 and December 31, 2015, and all linked embryo transfer cycles between January 1, 2014 and December 31, 2016, were included in the study...

OBJECTIVE: To evaluate population characteristics and obstetrical complications after abdominal myomectomy vs. laparoscopic myomectomy. DESIGN: Retrospective cohort study, using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample, with hospital discharge between 2004 and 2014. SETTINGS: Population-based. SUBJECT(S): 13868 and 338 pregnancies following abdominal or laparoscopic myomectomy, respectively...

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IMPORTANCE: Findings from several high-profile meta-analyses have raised concerns about an ongoing global decline in sperm concentration and male fertility. However, these studies exhibit considerable heterogeneity in key variables including study population, methodology, fertility status, and geographic region. OBJECTIVE: To perform a systematic review and meta-analysis exploring temporal trends in sperm concentration among fertile men and men unselected for fertility status in the United States...

OBJECTIVE: To study the association between sperm DNA fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. DESIGN: A prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding preeclampsia and perinatal outcomes were derived from the Swedish National Birth Register...