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Clinical Gastroenterology and Hepatology

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https://read.qxmd.com/read/30885888/neurologic-deficits-in-patients-with-newly-diagnosed-celiac-disease-are-frequent-and-linked-with-autoimmunity-to-tg6
#1
Marios Hadjivassiliou, Iain D Croall, Panagiotis Zis, Ptolemaios G Sarrigiannis, David S Sanders, Pascale Aeschlimann, Richard A Grünewald, Paul A Armitage, Daniel Connolly, Daniel Aeschlimann, Nigel Hoggard
BACKGROUND & AIMS: Celiac disease is an autoimmune disorder induced by ingestion of gluten that affects 1% of the population and is characterized by gastrointestinal symptoms, weight loss, and anemia. We evaluated the presence of neurologic deficits and investigated whether the presence of antibodies to TG6 increases the risk of neurologic defects in patients with a new diagnosis of celiac disease. METHODS: We performed a prospective cohort study at a secondary-care gastroenterology center of 100 consecutive patients who received a new diagnosis of celiac disease based on gastroscopy and duodenal biopsy...
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885887/combination-therapy-with-elimination-diet-and-corticosteroids-is-effective-for-adults-with-eosinophilic-esophagitis
#2
Craig C Reed, Manaswita Tappata, Swathi Eluri, Nicholas J Shaheen, Evan S Dellon
No abstract text is available yet for this article.
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885886/barriers-to-follow-up-colonoscopies-for-patients-with-positive-results-from-fecal-immunochemical-tests
#3
LETTER
Joseph Weiss, Danielle Weiss, Nancy S Cetel
No abstract text is available yet for this article.
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885885/are-high-dose-steroids-really-necessary-in-treatment-of-autoimmune-hepatitis
#4
EDITORIAL
Kalyan Ram Bhamidimarri, Paul Martin
No abstract text is available yet for this article.
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885884/barriers-to-use-of-palliative-care-and-advance-care-planning-discussions-for-patients-with-end-stage-liver-disease
#5
Nneka N Ufere, John Donlan, Lauren Waldman, Jules L Dienstag, Lawrence S Friedman, Kathleen E Corey, Nikroo Hashemi, Peter Carolan, Alan C Mullen, Michael Thiim, Irun Bhan, Ryan Nipp, Joseph A Greer, Jennifer S Temel, Raymond T Chung, Areej El-Jawahri
BACKGROUND & AIMS: Despite evidence for the benefits of palliative care (PC) referrals and early advance care planning (ACP) discussions for patients with chronic diseases, patients with end-stage liver disease (ESLD) often do not receive such care. We sought to examine physicians' perceptions of the barriers to PC and timely ACP discussions for patients with ESLD. METHODS: We conducted a cross-sectional survey of hepatologists and gastroenterologists who provide care to adult patients with ESLD, recruited from the American Association for the Study of Liver Diseases 2018 membership registry...
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885883/karnofsky-performance-status-following-liver-transplantation-in-patients-with-multiple-organ-failures-and-probable-acute-on-chronic-liver-failure
#6
Paul J Thuluvath, Avesh J Thuluvath, Yulia Savva, Talan Zhang
BACKGROUND & AIMS: Little is known about outcomes of patients who underwent liver transplantation for acute on chronic liver failure (ACLF) and multiple organ failures. We compared Karnofsky Performance Status (KPS) before and after liver transplantation among patients with different numbers of organ failures and probable ACLF. METHODS: We performed a retrospective cohort study, of adults who underwent liver transplantation within 30-days of listing with the United Network for Organ Sharing (UNOS) network from January 1, 2006 through September 30, 2016...
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30885882/benefits-from-and-barriers-to-portable-detection-of-gluten-based-on-a-randomized-pilot-trial-of-patients-with-celiac-disease
#7
Randi L Wolf, Peter H R Green, Anne R Lee, Norelle R Reilly, Patricia Zybert, Benjamin Lebwohl
No abstract text is available yet for this article.
March 15, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30880275/sustained-remission-of-eosinophilic-esophagitis-following-discontinuation-of-dietary-elimination-in-children
#8
Assaf Hoofien, Alexandra Papadopoulou, Carolina Gutiérrez-Junquera, Maria José Martínez Gómez, Gloria Domínguez-Ortega, Johanna Oudshoorn, Eleftheria Roma, Jorge Amil Dias, Salvatore Oliva, Luba Marderfeld, Noam Zevit
No abstract text is available yet for this article.
March 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30880274/accuracy-of-transient-elastography-data-combined-with-apri-in-detection-and-staging-of-liver-disease-in-pediatric-patients-with-cystic-fibrosis
#9
Peter J Lewindon, Mora V Puertolas-Lopez, Louise E Ramm, Charlton Noble, Tamara N Pereira, Julie A Wixey, Gunter F Hartel, Diego A Calvopina, Daniel H Leung, Grant A Ramm
BACKGROUND & AIMS: Liver disease develops in 15%-72% of patients with cystic fibrosis, and 5%-10% develop cirrhosis or portal hypertension, usually during childhood. Transient elastography (TE) is a noninvasive method to measure liver stiffness. We aimed to validate its accuracy in detection of liver disease and assessment of fibrosis in children with cystic fibrosis. METHODS: We performed a cross-sectional study to evaluate the accuracy of TE in analysis of liver fibrosis in 160 consecutive children who presented with cystic fibrosis (9...
March 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30880273/simple-magnetic-resonance-scores-associate-with-outcomes-of-patients-with-primary-sclerosing-cholangitis
#10
Sara Lemoinne, Nora Cazzagon, Sanaâ El Mouhadi, Palak J Trivedi, Anthony Dohan, Astrid Kemgang, Karima Ben Belkacem, Chantal Housset, Yves Chretien, Christophe Corpechot, Gideon Hirschfield, Annarosa Floreani, Raffaella Motta, Benoit Gallix, Alan Barkun, Jeffrey Barkun, Olivier Chazouillères, Lionel Arrivé
BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) has a variable, often progressive course. Magnetic resonance cholangiography (MRC) is used in diagnosis of PSC. Magnetic resonance risk scoring systems, called Anali without and with gadolinium, are used to predict disease progression, determined by radiologic factors. We aimed to assess the prognostic value of Anali scores in patients with PSC and validate our findings in a separate cohort. METHODS: We performed a retrospective study of patients with large-duct PSC (internal cohort, 119 patients in France and external cohort, 119 patients in Canada, Italy, and United Kingdom)...
March 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30880272/increased-cost-with-use-of-brand-name-bowel-preparation-by-patients-with-medicare-part-d-from-2013-to-2015
#11
Andrew J Read, Sandeep Vijan, Akbar K Waljee, Sameer D Saini
No abstract text is available yet for this article.
March 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30879982/correction
#12
(no author information available yet)
No abstract text is available yet for this article.
March 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876964/comparative-risk-of-serious-infections-with-biologic-and-or-immunosuppressive-therapy-in-patients-with-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#13
REVIEW
Siddharth Singh, Antonio Facciorusso, Parambir S Dulai, Vipul Jairath, William J Sandborn
BACKGROUND & AIMS: We performed a systematic review and meta-analysis to evaluate the comparative risk of serious infections with tumor necrosis factor (TNF) antagonists, non-TNF targeted biologics, tofacitinib, and immunosuppressive agents in patients with inflammatory bowel diseases (IBD). METHODS: In a systematic search of publications, through March 18, 2018, we identified 15 observational studies (>500 person-years) of patients with IBD treated with TNF antagonists, non-TNF targeted biologics, tofacitinib, and/or immunosuppressive agents (thiopurines, methotrexate) that reported risk of serious infections...
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876963/crohn-s-disease-is-associated-with-an-increased-prevalence-of-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-using-magnetic-resonance-proton-density-fat-fraction-mapping
#14
Scott McHenry, Yeshika Sharma, Ankita Tirath, Richard Tsai, Aaron Mintz, Tyler J Fraum, Amber Salter, Jeffrey D Browning, Avegail G Flores, Nicholas O Davidson, Kathryn J Fowler, Matthew A Ciorba, Parakkal Deepak
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876962/putting-the-horse-back-in-the-barn-right-sizing-use-of-anesthesia-assistance-for-routine-gastrointestinal-endoscopy
#15
EDITORIAL
Megan A Adams
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876961/black-esophagus-a-rare-cause-of-upper-gastrointestinal-bleeding
#16
Blake A Jacobs, George A Salem, Donald J Kastens
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876960/utility-of-genetic-testing-in-persons-with-multiple-colorectal-polyps
#17
EDITORIAL
Natalia Khalaf, Niloy Jewel Samadder
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876959/optimizing-use-of-nonalcoholic-fatty-liver-disease-fibrosis-score-fibrosis-4-score-and-liver-stiffness-measurement-to-identify-patients-with-advanced-fibrosis
#18
Wah-Kheong Chan, Sombat Treeprasertsuk, George Boon-Bee Goh, Jian-Gao Fan, Myeong Jun Song, Phunchai Charatcharoenwitthaya, Ajay Duseja, Yock-Young Dan, Kento Imajo, Atsushi Nakajima, Khek-Yu Ho, Khean-Lee Goh, Vincent Wai-Sun Wong
BACKGROUND & AIMS: Measuring liver stiffness in only patients with indeterminate or high nonalcoholic fatty liver disease (NAFLD) fibrosis scores (called a 2-step approach) was reported to reduce indeterminate or discordant results while maintaining the accuracy to identify patients with advanced fibrosis. We aimed to validate this approach using data collected from the Gut and Obesity in Asia Workgroup. METHODS: We performed a retrospective analysis of data from 759 patients with biopsy-proven NAFLD (24% with advanced fibrosis), seen at 10 centers in 9 countries in Asia, from 2006 through 2018...
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853617/patients-who-undergo-colectomy-for-pediatric-ulcerative-colitis-at-low-volume-hospitals-have-more-complications
#19
Matthew D Egberg, Joseph A Galanko, Michael D Kappelman
BACKGROUND & AIMS: Adults with ulcerative colitis (UC) who undergo colectomy at high-volume centers have better outcomes and fewer complications than those at low-volume centers. We aimed to evaluate hospital volume of total abdominal colectomy (TAC) for pediatric patients with UC and explore time trends in the proportion of colectomies performed at high-volume centers. We then evaluated the association between hospital colectomy volume and complications. METHODS: We performed a cross-sectional analysis of pediatric patients (≤18 years) hospitalized for UC using the Kids' Inpatient Database (KID), a nationally representative database of pediatric hospitalizations...
March 7, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853616/clinical-practice-guideline-for-the-management-of-luminal-crohn-s-disease-the-toronto-consensus
#20
Remo Panaccione, A Hillary Steinhart, Brian Bressler, Reena Khanna, John K Marshall, Laura Targownik, Waqqas Afif, Alain Bitton, Mark Borgaonkar, Usha Chauhan, Brendan Halloran, Jennifer Jones, Erin Kennedy, Grigorios I Leontiadis, Edward V Loftus, Jonathan Meddings, Paul Moayyedi, Sanjay Murthy, Sophie Plamondon, Greg Rosenfeld, David Schwartz, Cynthia H Seow, Chadwick Williams, Charles N Bernstein
BACKGROUND & AIMS: Crohn's disease (CD) is a lifelong illness with substantial morbidity, although new therapies and treatment paradigms have been developed. We provide guidance for treatment of ambulatory patients with mild to severe active luminal CD. METHODS: We performed a systematic review to identify published studies of the management of CD. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach...
March 7, 2019: Clinical Gastroenterology and Hepatology
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