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Journals Clinical Gastroenterology and ...

Clinical Gastroenterology and Hepatology

https://read.qxmd.com/read/33845217/reply-to-stratifying-the-risk-of-ipmns-don-t-rule-out-the-eus-toolkit
#1
LETTER
Stefano Crippa, Massimo Falconi
No abstract text is available yet for this article.
April 9, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33845216/perianal-crohn-s-disease-is-associated-with-poor-disease-outcome-a-nation-wide-study-from-the-epiiirn-cohort
#2
Ohad Atia, Noa Asayag, Gili Focht, Rona Lujan, Oren Ledder, Shira Greenfeld, Revital Kariv, Iris Dotan, Hagit Gabay, Ran Balicer, Ziona Haklai, Daniel Nevo, Dan Turner
BACKGROUND & AIMS: Limited population-based data have explored perianal involvement in Crohn's disease (CD) and compared the disease course between severe and non-severe perianal CD (PCD). We aimed to explore the disease course of these phenotypes in a population-based study of CD. METHODS: Cases were identified from the epi-IIRN cohort and included two Israeli Health Maintenance Organizations, covering 78% of the population. We validated specific algorithms to identify fistulizing PCD and to differentiate severe from non-severe disease by medication utilization, ICD-9 codes and perianal procedures...
April 9, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839280/reply-a-patient-perspective-on-contemporary-risk-of-surgery-in-patients-with-ulcerative-colitis-and-crohn-s-disease
#3
LETTER
Katelin Roth, Jeffrey A Berinstein
No abstract text is available yet for this article.
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839279/reply-to-letter-to-editor-by-dr-uemura-et-al
#4
LETTER
Eugenia Shmidt, David M Faleck, Jean-Frederic Colombel
No abstract text is available yet for this article.
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839278/response-bowel-movements-and-risk-of-diverticulitis
#5
LETTER
Manol Jovani, Lisa L Strate, Andrew T Chan
No abstract text is available yet for this article.
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839277/detection-of-colorectal-neoplasms-using-linked-color-imaging-a-prospective-randomized-tandem-colonoscopy-trial
#6
Issei Hasegawa, Takeshi Yamamura, Hiroto Suzuki, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Masanao Nakamura, Mitsuhiro Fujishiro
BACKGROUND AND AIMS: A higher adenoma detection rate (ADR) has been shown to be related to a lower incidence and mortality of colorectal cancer. We analyzed the efficacy of linked color imaging (LCI) by assessing the detection, miss, and visibility of various featured adenomas as compared with white light imaging (WLI). METHODS: This was a prospective, randomized, tandem trial. The participants were randomly assigned to two groups: first observation by LCI, then second observation by WLI (LCI group); or both observations by WLI (WLI group)...
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839276/overlap-of-rome-iv-irritable-bowel-syndrome-and-functional-dyspepsia-and-effect-on-natural-history-a-longitudinal-follow-up-study
#7
Brigida Barberio, Yan Yiannakou, Lesley A Houghton, Christopher J Black, Edoardo V Savarino, Alexander C Ford
OBJECTIVES: Disorders of gut-brain interaction, such as irritable bowel syndrome (IBS) and functional dyspepsia (FD) frequently overlap, but the impact of this on the natural history is unknown. We examined this issue in a longitudinal follow-up study conducted in a large cohort of individuals. METHODS: We collected complete demographic, symptom, mood, and psychological health data from 1374 adults who self-identified as having IBS. We applied the Rome IV criteria to examine what proportion met criteria for IBS and FD, as well as the degree of overlap between them...
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839275/implicit-bias-in-region-dependent-publication-potential-can-partly-be-counteracted-by-academic-collaboration
#8
LETTER
Maikel P Peppelenbosch, Carmen V Ferreira
No abstract text is available yet for this article.
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839274/maintenance-therapy-in-crohn-s-disease-does-the-drug-matter
#9
LETTER
Alexander Ng
No abstract text is available yet for this article.
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33839273/the-prevalence-and-predictors-of-missed-dysplasia-on-index-barrett-s-esophagus-diagnosing-endoscopy-in-a-veteran-population
#10
Theresa H Nguyen, Aaron P Thrift, Rollin George, Daniel G Rosen, Hashem B El-Serag, Gyanprakash A Ketwaroo
BACKGROUND & AIMS: Limitations of endoscopic sampling may result in missed dysplasia at the diagnosis of Barrett's esophagus (BE). However, the role of close follow-up endoscopy is unclear. The aim was to evaluate the proportion of patients diagnosed with 'missed' dysplasia within 18 months of their index non-dysplastic BE (NDBE) diagnosis. METHODS: This was a retrospective analysis of a cohort of BE patients diagnosed during 1990-2019 at the Houston VA. Patients with BE on index esophagogastroduodenoscopy (EGD) were classified as NDBE, indefinite dysplasia, or dysplastic (low- or high-grade dysplasia) based on initial biopsies...
April 8, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33838349/lubiprostone-for-pediatric-functional-constipation-randomized-controlled-double-blind-study-with-long-term-extension
#11
Marc A Benninga, Sunny Z Hussain, Manu R Sood, Samuel Nurko, Paul Hyman, Robert A Clifford, Molly O'Gorman, Taryn Losch-Beridon, Shadreck Mareya, Peter Lichtlen, Carlo Di Lorenzo
BACKGROUND & AIMS: Pediatric functional constipation (PFC) is a common problem in children that causes distress and presents treatment challenges to healthcare professionals. We conducted a randomized, placebo-controlled trial (Study 1) in patients with PFC (aged 6-17 years) to evaluate the efficacy and safety of lubiprostone, followed by an open-label extension for those who completed the placebo-controlled phase (Study 2). METHODS: Study 1 (NCT02042183) was a phase 3, multicenter, randomized, double-blind, placebo-controlled, 12-week study evaluating the efficacy and safety of lubiprostone 12 mcg twice-daily (BID) and 24 mcg BID...
April 7, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33838348/comparative-efficacy-and-rapidity-of-action-for-infliximab-vs-ustekinumab-in-biologic-naive-crohn-s-disease
#12
Neeraj Narula, Emily C L Wong, Parambir S Dulai, Neil K Sengupta, John K Marshall, Jean-Frederic Colombel, Walter Reinisch
BACKGROUND AND AIMS: Comparative effectiveness have become increasingly important to help position therapies for inflammatory bowel disease. We compared the efficacy and rapidity of onset of action of infliximab vs. ustekinumab induction therapy for moderate to severe biologic-naïve Crohn's disease (CD) using patient-level data from randomized controlled trials. METHODS: This was a post-hoc analysis of two large CD clinical trial programs which included data on 420 biologic-naïve CD patients...
April 7, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33823292/response-to-defining-age-related-thresholds-for-alt-and-the-risk-of-confounders-by-daniel-q-huang-mindie-h-nguyen
#13
LETTER
David Petroff, Thomas Berg, Johannes Wiegand
No abstract text is available yet for this article.
April 3, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33823291/a-single-food-milk-elimination-diet-is-effective-for-treatment-of-eosinophilic-esophagitis-in-children
#14
Joshua B Wechsler, Sally Schwartz, Nicoleta C Arva, Kwang-Youn A Kim, Liqi Chen, Melanie Makhija, Katie Amsden, Kaitlin Keeley, Saeed Mohammed, Evan S Dellon, Amir F Kagalwalla
BACKGROUND: Cow's milk protein (CMP) is the most common trigger of inflammation in children and adults with Eosinophilic Esophagitis (EoE). We sought to assess the clinical, endoscopic, and histological efficacy of dietary elimination of all CM protein-containing foods in EoE. METHODS: We performed a prospective observational study in children with EoE treated with One Food Elimination Diet (1FED) excluding all CMP. Children and their caretakers were educated by a registered dietitian regarding dietary elimination of all CM protein-containing foods with substitutions to meet nutritional needs for optimal growth and development, and daily meal planning...
April 3, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33819667/an-impetus-for-change-how-covid-19-will-transform-the-delivery-of-gi-healthcare
#15
David A Leiman, Michael L Weinstein, Megan A Adams
No abstract text is available yet for this article.
April 2, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33819666/advances-in-the-comprehensive-management-of-post-operative-crohn-s-disease
#16
REVIEW
Robert Battat, William J Sandborn
Patients with post-operative Crohn's disease are difficult to manage due to their risk of experiencing a more severe course, multiple symptom confounders and poor sensitivity of symptomatic remission to rule out intestinal inflammation. In this group, data are lacking on biologic therapeutic efficacy and recommendations are lacking for those with multiple medication failures. Novel non-invasive testing can simultaneously exclude alternate causes of symptoms (serum C4, fecal fat, SIBO breath testing) and assess intestinal inflammation (fecal calprotectin, endoscopic healing index)...
April 2, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33819665/response-to-letter-to-the-editor-by-dr-alexander-ng
#17
LETTER
Hajime Yamazaki, Jui Wang, Yosuke Yamamoto
No abstract text is available yet for this article.
April 2, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33813074/association-of-weight-changes-with-changes-in-histological-features-and-blood-markers-in-non-alcoholic-steatohepatitis
#18
Dimitrios A Koutoukidis, Susan A Jebb, Jeremy W Tomlinson, Jeremy F Cobbold, Paul Aveyard
BACKGROUND AND AIMS: Weight loss is recommended for patients with non-alcoholic steatohepatitis (NASH) but the impact of weight change on disease activity remains unclear. We examined the association between weight change (gain/loss) and changes in biochemical and histological features of NASH. METHODS: This was an analysis of the PIVENS and FLINT trials in adults with NASH who had liver biopsies at baseline and at either 1.5 years or 2 years. Multivariable regression models examined how weight change was associated with changes in (a) blood liver markers, (b) NASH resolution with no fibrosis worsening, (c) fibrosis improving with no NASH worsening, and (d) individual histological features...
April 1, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33813073/defining-the-long-term-clinical-course-and-need-for-repeat-dilation-for-patients-with-schatzki-rings
#19
Amrit K Kamboj, Saam Dilmaghani, Beth A Schueler, John M Barlow, David A Katzka
No abstract text is available yet for this article.
April 1, 2021: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/33813072/aga-clinical-practice-update-on-the-optimal-management-of-the-malignant-alimentary-tract-obstruction-expert-review
#20
Osman Ahmed, Jeffrey H Lee, Christopher C Thompson, Ashley Faulx
DESCRIPTION: The purpose of this expert review is to describe the current methodologies available to manage malignant alimentary tract obstructions as well the evidence behind the various methods (including their efficacy and safety), indications and appropriate timing of interventions. METHODS: This is not a formal systematic review but is based upon a review of the literature to provide best practice advice statements. No formal rating of the quality of evidence or strength of recommendation is carried out...
April 1, 2021: Clinical Gastroenterology and Hepatology
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