David Haan, Anna Bergamaschi, Verena Friedl, Gulfem D Guler, Yuhong Ning, Roman Reggiardo, Michael Kesling, Micah Collins, Bill Gibb, Kyle Hazen, Steve Bates, Michael Antoine, Carolina Fraire, Vanessa Lopez, Roger Malta, Maryam Nabiyouni, Albert Nguyen, Tierney Phillips, Michael Riviere, Anna Leighton, Christopher Ellison, Erin McCarthy, Aaron Scott, Lauren Gigliotti, Eric Nilson, Judith Sheard, Melissa Peters, Kelly Bethel, Shimul Chowdhury, Wayne Volkmuth, Samuel Levy
BACKGROUND & AIMS: Early detection of pancreatic cancer (PaC) can drastically improve survival rates. Approximately 25% of subjects with PaC have type 2 diabetes diagnosed within 3 years prior to the PaC diagnosis, suggesting that subjects with type 2 diabetes are at high risk of occult PaC. We have developed an early-detection PaC test, based on changes in 5-hydroxymethylcytosine (5hmC) signals in cell-free DNA from plasma. METHODS: Blood was collected from 132 subjects with PaC and 528 noncancer subjects to generate epigenomic and genomic feature sets yielding a predictive PaC signal algorithm...
March 24, 2023: Clinical Gastroenterology and Hepatology