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Clinical Gastroenterology and Hepatology

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https://read.qxmd.com/read/31520730/effects-of-pancreatic-enzyme-replacement-therapy-on-body-weight-and-nutritional-assessments-after-pancreatoduodenectomy-in-a-randomized-trial
#1
Hongbeom Kim, Yoo Seok Yoon, Youngmin Han, Wooil Kwon, Sun-Whe Kim, Ho-Seong Han, Dong-Sup Yoon, Joon Seong Park, Sang-Jae Park, Sung-Sik Han, Seung Eun Lee, Seong Ho Choi, In Woong Han, Eunjung Kim, Jin-Young Jang
BACKGROUND & AIMS: We studied the effects of pancreatic enzyme replacement therapy (PERT) on body weight, nutritional status, and quality of life (QoL) in patients with pancreatic exocrine insufficiency after pancreatoduodenectomy. METHODS: We performed a randomized, double-blind trial of 304 patients who underwent pancreatoduodenectomy at 7 tertiary referral hospitals in South Korea. Patients with fecal levels of elastase of 200 μg/g at or less, before and after surgery, were randomly assigned to groups that received PERT (a single capsule of 40,000 IU pancreatin, Norzyme, 3 times each day during meals for 3 months; n=151) or placebo (n=153)...
September 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31520729/oral-crohn-s-disease-the-proof-is-in-the-cinnamon-free-pudding
#2
Benjamin Crooks, Chris S Probert, Jimmy K Limdi
No abstract text is available yet for this article.
September 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31520728/serrated-polyposis-syndrome
#3
Gautam Mankaney, Carol Rouphael, Carol A Burke
No abstract text is available yet for this article.
September 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31518719/reducing-hospital-admissions-for-paracentesis-a-quality-improvement-intervention
#4
Shazia Mehmood Siddique, Stefanie Porges, Meghan Lane-Fall, Shivan Mehta, William Schweickert, Joan Kinniry, April Taylor, James D Lewis, Shaz Iqbal, David Goldberg, Judy A Shea, Robert Stetson, Mary Coniglio, Maarouf Hoteit, Neil Fishman, Vandana Khungar
No abstract text is available yet for this article.
September 10, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31518718/adherence-to-biopsy-and-follow-up-guidelines-in-a-population-based-cohort-of-children-with-eosinophilic-esophagitis
#5
Amber McClain, Molly O'Gorman, Carlos Barbagelata, Raza Patel, Amy Lowichik, Kathryn Peterson, Stephen Guthery, Jacob Robson
No abstract text is available yet for this article.
September 10, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31518717/magnetic-sphincter-augmentation-superior-to-proton-pump-inhibitors-for-regurgitation-in-a-1-year-randomized-trial
#6
Reginald Bell, John Lipham, Brian E Louie, Valerie Williams, James Luketich, Michael Hill, William Richards, Christy Dunst, Dan Lister, Lauren McDowell-Jacobs, Patrick Reardon, Karen Woods, Jon Gould, F Paul Buckley, Shanu Kothari, Leena Khaitan, C Daniel Smith, Adrian Park, Christopher Smith, Garth Jacobsen, Ghulam Abbas, Philip Katz
BACKGROUND & AIMS: Regurgitative gastroesophageal reflux disease (GERD) refractive to medical treatment is common and caused by mechanical failure of the anti-reflux barrier. We compared the effects of magnetic sphincter augmentation (MSA) with those of proton-pump inhibitors (PPIs) in a randomized trial. METHODS: Patients with moderate to severe regurgitation (assessed by the foregut symptom questionnaire) despite once-daily PPI therapy (n=152) were randomly assigned to groups given twice-daily PPIs (n=102) or laparoscopic MSA (n=50) at 20 sites, from July 2015 through February 2017...
September 10, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31518716/younger-physicians-and-longer-withdrawal-times-are-associated-with-detection-of-advanced-neoplasia-in-a-large-community-practice
#7
Aasma Shaukat, Amy A Gravely, Adam Kim, Timothy R Church, John I Allen
No abstract text is available yet for this article.
September 10, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31518715/absence-of-iodine-staining-associates-with-progression-of-esophageal-lesions-in-a-prospective-endoscopic-surveillance-study-in-china
#8
Mengfei Liu, Zhen Liu, Fangfang Liu, Chuanhai Guo, Ruiping Xu, Fenglei Li, Anxiang Liu, Haijun Yang, Sanshen Zhang, Lin Shen, Liping Duan, Qi Wu, Changqi Cao, Yaqi Pan, Ying Liu, Jingjing Li, Hong Cai, Zhonghu He, Yang Ke
BACKGROUND & AIMS: Chromoendoscopy with iodine staining is used to identify esophageal squamous dysplasia and esophageal squamous cell carcinomas (ESCCs)-absence of staining indicates suspicious regions of dysplasia. However, screening detects precancerous lesions (mild and moderate dysplasia) that do not require immediate treatment; it is a challenge to which lesions are at risk for progression. We investigated the association between absence of iodine staining at chromoendoscopy screening and lesion progression using 6 years of follow-up data from a population-based randomized controlled trial in China...
September 10, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499252/upper-gastrointestinal-bleeding-due-to-cameron-lesions
#9
Flávio Pereira, João Pinto, José Tristan
No abstract text is available yet for this article.
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499251/persistent-basal-cell-hyperplasia-is-associated-with-clinical-and-endoscopic-findings-in-patients-with-histologically-inactive-eosinophilic-esophagitis
#10
Kelly A Whelan, Bridget C Godwin, Benjamin Wilkins, Okan U Elci, Alain Benitez, Maureen DeMarshall, Medha Sharma, Jonathan Gross, Andres J Klein-Szanto, Chris A Liacouras, Evan S Dellon, Jonathan M Spergel, Gary W Falk, Amanda B Muir, Hiroshi Nakagawa
BACKGROUND & AIMS: Although eosinophil count is the standard used to monitor disease activity in patients with eosinophilic esophagitis (EoE), there are often disparities between patient-reported symptoms and eosinophil counts. We examined the prevalence of epithelial alterations, namely basal cell hyperplasia (BCH) and spongiosis, among patients with inactive EoE (eosinophil counts below 15 following therapy) and aimed to determine whether maintenance of these changes in epithelial morphology are associated with persistent clinical findings...
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499250/proteomic-discovery-of-stool-protein-biomarkers-for-distinguishing-pediatric-inflammatory-bowel-disease-flares
#11
Ellen Casavant, K T Park, Joshua E Elias
No abstract text is available yet for this article.
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499249/rapid-recurrence-of-eosinophilic-esophagitis-activity-after-successful-treatment-in-the-observation-phase-of-a-randomized-double-blind-double-dummy-trial
#12
Evan S Dellon, John T Woosley, Ashley Arrington, Sarah J McGee, Jacquelyn Covington, Susan E Moist, Jessica H Gebhart, Joseph A Galanko, John A Baron, Nicholas J Shaheen
BACKGROUND AND AIMS: Eosinophilic esophagitis (EoE) is chronic and recurs if treatment is discontinued. We aimed to determine rates of recurrence, and whether initial treatment with oral viscous budesonide (OVB) resulted in less recurrence than fluticasone from a multi-dose inhaler (MDI). METHODS: This was the observation phase of a randomized, double-blind, double-dummy trial comparing OVB to MDI for initial EoE treatment. Subjects with histologic response (fewer than 15 eosinophils/high-power field) in the trial entered an observation phase in which treatment was discontinued and symptoms were monitored...
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499248/metastatic-renal-cell-carcinoma-to-the-gastrointestinal-tract
#13
Alyssa Grossen, Donald J Kastens, George Salem
No abstract text is available yet for this article.
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499247/qualitative-and-quantitative-contrast-enhanced-endoscopic-ultrasound-improves-evaluation-of-focal-pancreatic-lesions
#14
James Buxbaum, Chris Ko, Bino Varghese, Alice Lee, Ara Sahakian, Kevin King, Jessica Serna, Helen Lee, Hisham Tchelepi, Jacques Van Dam, Vinay Duddalwar
BACKGROUND & AIMS: Endoscopic ultrasound (EUS) is a sensitive method to evaluate the pancreas but its diagnostic capability for several diseases is limited. We compared the diagnostic yield of unenhanced EUS with that of contrast-enhanced EUS for focal pancreas lesions and identified and tested quantitative parameters of contrast enhancement. METHODS: We performed a prospective tandem-controlled trial in which 101 patients with focal pancreas lesions (48 with masses, 28 with cysts, and 25 with pancreatitis) underwent conventional EUS followed by contrast EUS using intravenous perflutren microspheres...
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31499246/widespread-gastrointestinal-kaposi-sarcoma-in-an-hiv-negative-real-transplant-patient
#15
Shiva Shankar Vangimalla, Amaninder Dhaliwal, Ishfaq Bhat
No abstract text is available yet for this article.
September 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31493578/primary-sclerosing-cholangitis-in-children-with-inflammatory-bowel-diseases-is-associated-with-milder-clinical-activity-but-more-frequent-subclinical-inflammation-and-growth-impairment
#16
Amanda Ricciuto, Bettina E Hansen, Brian Ngo, Marina Aloi, Thomas D Walters, Peter C Church, Abigail Mazurek, Maryam Khan, Nicholas Carman, Iram Siddiqui, Geoffrey C Nguyen, Binita M Kamath, Anne M Griffiths
BACKGROUND & AIMS: Although inflammatory bowel diseases (IBD) associated with primary sclerosing cholangitis (PSC) have been well characterized in adults, there have been few pediatric studies, and these were small and produced conflicting results. We investigated features of PSC-IBD in children, compared to children with IBD without PSC. METHODS: We performed a retrospective study of 74 children with PSC-IBD, diagnosed from 2000 through 2018, who were each matched with 2 children with ulcerative colitis or IBD-unclassified (controls) based on sex, date of birth, and type of IBD...
September 4, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31476436/comparative-efficacy-of-treatment-options-for-minimal-hepatic-encephalopathy-a-systematic-review-network-meta-analysis
#17
Radha K Dhiman, Kiran K Thumburu, Nipun Verma, Madhu Chopra, Sahaj Rathi, Usha Dutta, Ashwani K Singal, Sunil Taneja, Ajay Duseja, Meenu Singh
BACKGROUND & AIMS: To synthesize evidence for most effective treatment for minimal hepatic encephalopathy (HE). METHODS: A systematic search of the PubMed, EMBASE, OvidSP and CENTRAL databases for randomized-controlled-trials evaluating treatments for minimal HE in cirrhotics was conducted from their inception to 26th July2018. Primary outcomes were reversal of minimal HE and prevention of overt HE. Meta-analysis (MA) followed by network meta-analysis (NMA) and surface under cumulated ranking (SUCRA) was conducted to pool the direct and indirect estimates and rank the different treatments...
August 30, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31473361/high-intake-of-phenolic-acid-is-associated-with-reduced-risk-of-colorectal-adenomas-among-smokers
#18
N Fliss-Isakov, G Grosso, F Salomone, J Godos, F Gavalno, D Ivancovsky-Wajcman, O Shibolet, R Kariv, S Zelber-Sagi
No abstract text is available yet for this article.
August 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31473360/frequent-integration-of-hbv-dna-in-genomes-of-hepatocellular-carcinoma-cells-from-patients-with-occult-infections
#19
EDITORIAL
Nathalie Wong
No abstract text is available yet for this article.
August 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31473359/reliability-of-endoscopic-evaluation-of-postoperative-recurrent-crohn-s-disease
#20
Christopher Ma, Krisztina B Gecse, Marjolijn Duijvestein, William J Sandborn, Guangyong Zou, Lisa M Shackleton, Larry W Stitt, Claire E Parker, Peter Bossuyt, Mark Löwenberg, Reena Khanna, Severine Vermeire, Paul Rutgeerts, Brian G Feagan, Vipul Jairath, Geert R D'Haens
No abstract text is available yet for this article.
August 29, 2019: Clinical Gastroenterology and Hepatology
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