journal

Clinical Gastroenterology and Hepatology

journal
https://read.qxmd.com/read/31945470/first-and-second-line-pharmacotherapies-for-patients-with-moderate-to-severely-active-ulcerative-colitis-an-updated-network-meta-analysis
#1
REVIEW
Siddharth Singh, Mohammad Hassan Murad, Mathurin Fumery, Parambir S Dulai, William J Sandborn
BACKGROUND & AIMS: We compared the efficacy and safety of different first-line (biologic-naïve) and second-line (prior exposure to tumor necrosis factor [TNF] antagonists) agents for treatment of moderate to severely active ulcerative colitis in a systematic review and network meta-analysis. METHODS: We searched publication databases through September 30, 2019 for randomized trials of adults with moderate to severe ulcerative colitis treated with TNF antagonists, vedolizumab, tofacitinib, or ustekinumab, as first-line or second-line agents, compared with placebo or another active agent...
January 13, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31931181/a-model-to-identify-heavy-drinkers-at-high-risk-for-liver-disease-progression
#2
Claire Delacôte, Pierre Bauvin, Alexandre Louvet, Flavien Dautrecque, Line Carolle Ntandja Wandji, Guillaume Lassailly, Cosmin Voican, Gabriel Perlemuter, Sylvie Naveau, Philippe Mathurin, Sylvie Deuffic-Burban
BACKGROUND & AIMS: Alcohol-related liver disease (ALD) causes chronic liver disease. We investigated how information on patients' drinking history and amount, stage of liver disease, and demographic feature can be used to determine risk of disease progression. METHODS: We collected data from 2334 heavy drinkers (50 g/day or more) with persistently abnormal results from liver tests who had been admitted to a hepato-gastroenterology unit in France from January 1982 through December 1997; patients with a recorded duration of alcohol abuse were assigned to the development cohort (n=1599; 75% men) or the validation cohort (n=735; 75% men), based on presence of a liver biopsy...
January 10, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31931180/giant-inguinal-hernia-in-a-decompensated-cirrhotic-patient
#3
Luísa Leite Barros, Marilia Galvão Cruz, Alberto Queiroz Farias
No abstract text is available yet for this article.
January 10, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927112/hepatitis-c-care-pathway-associated-with-increased-screening-confirmation-and-diagnosis-communication-to-patients
#4
Carla Rodriguez-Watson, Kevin B Rubenstein, M Cabell Jonas, Yan Sun, Michael Horberg, Bernadette Loftus
No abstract text is available yet for this article.
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927111/coordination-of-care-associated-with-survival-and-healthcare-utilization-in-a-population-based-study-of-patients-with-cirrhosis
#5
Shirley Cohen-Mekelburg, Akbar K Waljee, Brooke C Kenney, Elliot B Tapper
BACKGROUND & AIMS: Improving care coordination for patients with high-intensity specialty care needs, such as cirrhosis, can increase quality of healthcare and reduce utilization. We examined the relationship between care concentration and risk of hospitalization for patients with cirrhosis. METHODS: We performed a retrospective cohort study of 26,006 Medicare enrollees with cirrhosis with more than 4 outpatient visits over 180 days. We collected data on 2 validated measures of care concentration: the usual provider of care (UPC) index, a measure of the proportion of a patient's total visits that is with their most regularly seen provider, and the continuity of care (COC) index, a measure of care density and dispersion...
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927110/high-dietary-intake-of-vegetable-or-polyunsaturated-fats-is-associated-with-reduced-risk-of-hepatocellular-carcinoma
#6
Wanshui Yang, Jing Sui, Yanan Ma, Tracey G Simon, Jessica L Petrick, Michelle Lai, Katherine A McGlynn, Peter T Campbell, Edward L Giovannucci, Andrew T Chan, Xuehong Zhang
BACKGROUND & AIMS: We investigated associations of intake of total fats, specific dietary fats, and fats from different food sources with risk of hepatocellular carcinoma (HCC) using data from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). METHODS: We analyzed data from a total of 138,483 women and men who participated in the NHS or HPFS. A validated semi-quantitative food frequency questionnaire was sent to NHS participants in 1980, 1984, 1986, and every 4 years thereafter; dietary information was collected from participants in the HPFS in 1986 and every 4 years thereafter...
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927109/a-cutaneous-clue-to-a-tropical-cause-of-acute-pancreatitis-scrub-typhus
#7
Deepak James, Vishal Sharma
No abstract text is available yet for this article.
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927108/provocative-tests-on-esophageal-high-resolution-manometry-prior-to-surgical-fundoplication-expanding-the-manometry-protocol
#8
LETTER
Stephen Hasak, L Michael Brunt, Dan Wang, C Prakash Gyawali
No abstract text is available yet for this article.
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927107/black-esophagus-acute-esophageal-necrosis
#9
Ishaan Vohra, Bashar Attar, Anas Almoghrabi
No abstract text is available yet for this article.
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927106/a-scoring-system-to-determine-patients-risk-of-colectomy-within-1-y-after-hospital-admission-for-acute-severe-ulcerative-colitis
#10
G Le Baut, J Kirchgesner, A Amiot, J H Lefevre, N Chafai, C Landman, I Nion, A Bourrier, C Delattre, C Martineau, H Sokol, P Seksik, Y Nguyen, Y Marion, G Lebreton, F Carbonnel, S Viennot, L Beaugerie
BACKGROUND & AIMS: There is consensus on the criteria used to define acute severe ulcerative colitis (ASUC) and on patient management, but it has been a challenge to identify patients at risk for colectomy based on data collected at hospital admission. We aimed to develop a system to determine patients' risk of colectomy within 1 y of hospital admission for ASUC based on clinical, biomarker, and endoscopy data. METHODS: We performed a retrospective analysis of consecutive patients with ASUC treated with corticosteroids, ciclosporin, or tumor necrosis factor (TNF) antagonists and admitted to 2 hospitals in France from 2002 through 2017...
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31927105/inpatient-management-of-inflammatory-bowel-disease-related-complications
#11
REVIEW
Manreet Kaur, Robin L Dalal, Seth Shaffer, David A Schwartz, David T Rubin
Despite advances in therapeutic options, a sizeable proportion of patients with inflammatory bowel disease require hospitalization or surgery during their lifetime. While current treatment guidelines for the management of ulcerative colitis and Crohn's disease cover the spectrum of disease severity and behavior, management of acute complications of inflammatory bowel disease can present unique challenges that are not always addressed in these guidelines. In this review, the authors provide a comprehensive summary of the existing literature focused on management of patients hospitalized with complications of inflammatory bowel disease...
January 9, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31926340/effects-of-apremilast-an-oral-inhibitor-of-phosphodiesterase-4-in-a-randomized-trial-of-patients-with-active-ulcerative-colitis
#12
Silvio Danese, Markus F Neurath, Adam Kopoń, Salam F Zakko, Timothy C Simmons, Ronald Fogel, Corey A Siegel, Remo Panaccione, Xiaojiang Zhan, Keith Usiskin, Denesh Chitkara
BACKGROUND & AIMS: New oral therapeutic agents are needed for patients with ulcerative colitis (UC) who are unresponsive or intolerant to conventional therapy. METHODS: We performed a double-blind, phase 2 trial of adults with active UC for 3 months or more who were naïve to biologic therapy or had been failed by, could not tolerate, or had contraindications to conventional therapies. The study was performed at 61 sites in 14 countries (screening from January 2015 through May 2017)...
January 8, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31926339/vitamin-d-status-may-help-explain-racial-disparities-in-pancreatic-cancer-incidence-and-mortality-in-the-united-states
#13
LETTER
William B Grant
No abstract text is available yet for this article.
January 8, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31926338/reply-alcohol-use-patterns-and-liver-outcomes-is-there-really-a-difference-between-drinking-beer-and-drinking-wine
#14
LETTER
Michelle T Long, Timothy S Naimi
No abstract text is available yet for this article.
January 8, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31926337/who-is-at-risk-for-early-onset-colorectal-cancer
#15
EDITORIAL
Jennifer K Maratt, Charles J Kahi
No abstract text is available yet for this article.
January 8, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31923642/development-and-validation-of-the-asia-pacific-proximal-colon-neoplasia-risk-score
#16
Martin Cs Wong, Rungsun Rerknimitr, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Deng-Chyang Wu, Kai Chun Wu, Khay Guan Yeoh, Vui Heng Chong, Furqaan Ahmed, Jose D Sollano, Jayaram Menon, Han-Mo Chiu, Jingnan Li, Jessica Yl Ching, Joseph Jy Sung
BACKGROUND & AIMS: Patients found to be at high risk of advanced proximal neoplasia (APN) after flexible sigmoidoscopy screening should be considered for colonoscopy examination. We developed and validated a scoring system to identify persons at risk for APN. METHODS: We collected data from 7954 asymptomatic subjects (50-75 years old) who received screening colonoscopy examinations at 14 sites in Asia. We randomly assigned 5303 subjects to the derivation cohort and the remaining 2651 to the validation cohort...
January 7, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31923641/clinical-validation-of-basic-classification-for-the-resect-and-discard-strategy-for-diminutive-colorectal-polyps
#17
Emanuele Rondonotti, Cesare Hassan, Alida Andrealli, Silvia Paggi, Arnaldo Amato, Lucia Scaramella, Alessandro Repici, Franco Radaelli
BACKGROUND & AIMS: Blue-light imaging (BLI) is a chromoendoscopy technique that uses direct (not filtered) emission of blue light with short wavelength (410 nm) to increase visibility of microvascular pattern and superficial mucosa. A BLI-based classification system for colorectal polyps (also called BLI Adenomas Serrated International Classification, BASIC) has been created and was validated using still images or short videos. We aimed to validate BASIC in a clinical practice setting, using thresholds recommended by the American Society for Gastrointestinal Endoscopy for the resect and discard strategy as the reference standard...
January 7, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31923640/frequency-of-eating-disorder-pathology-among-patients-with-chronic-constipation-and-contribution-of-gastrointestinal-specific-anxiety
#18
Helen B Murray, Ryan Flanagan, Bryana Banashefski, Casey J Silvernale, Braden Kuo, Kyle Staller
BACKGROUND AIMS: Individuals with eating disorders (EDs) frequently have constipation-related symptoms, although the mechanisms of this relationship are not clear. We examined the frequency of and relation between EDs and constipation in patients with chronic constipation referred for anorectal manometry. METHODS: We analyzed data from 279 patients with chronic constipation (79.2% female) seen at a tertiary center from June 2017 through September 2018. Participants completed a standardized psychometric assessment (patient assessment of constipation symptoms questionnaire and hospital anxiety and depression scale and visceral sensitivity index analyses) and anorectal manometry...
January 7, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31923639/fecal-microbiota-transplant-decreases-mortality-in-patients-with-refractory-severe-or-fulminant-clostridioides-difficile-infection
#19
Yao-Wen Cheng, Emmalee Phelps, Sara Nemes, Nicholas Rogers, Sashidhar Sagi, Matthew Bohm, Mustapha El-Halabi, Jessica R Allegretti, Zain Kassam, Huiping Xu, Monika Fischer
BACKGROUND & AIMS: Fecal microbiota transplantation (FMT) is recommended for recurrent Clostridioides difficile infection (CDI). FMT cures nearly 80% of patients with severe or fulminant CDI (SFCDI) when utilized in a sequential manner. We compared outcomes of hospitalized patients before and after implementation of an FMT program for SFCDI and investigated whether the changes could be directly attributed to the FMT program. METHODS: We performed a retrospective analysis of characteristics and outcomes of patients hospitalized for SFCDI (430 hospitalizations) at a single center, from January 2009 through December 2016...
January 7, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31887451/high-throughput-machine-learning-based-quantification-of-steatosis-inflammation-ballooning-and-fibrosis-in-biopsies-from-patients-with-nonalcoholic-fatty-liver-disease
#20
Roberta Forlano, Benjamin H Mullish, Nikolaos Giannakeas, James B Maurice, Napat Angkathunyakul, Josephine Lloyd, Alexandros T Tzallas, Markos Tsipouras, Michael Yee, Mark R Thursz, Robert D Goldin, Pinelopi Manousou
BACKGROUND & AIMS: Liver biopsy is the reference standard for staging and grading non-alcoholic fatty liver disease (NAFLD), but histologic scoring systems are semi-quantitative with marked inter- and intra-observer variation. We used machine learning to develop fully automated software for quantification of steatosis, inflammation, ballooning, and fibrosis in biopsies from patients with NAFLD and validated the technology in a separate group of patients. METHODS: We collected data from 246 consecutive patients with biopsy-proven NAFLD and followed in London, the United Kingdom, from January 2010 through December 2016...
December 27, 2019: Clinical Gastroenterology and Hepatology
journal
journal
20073
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"