journal

Clinical Gastroenterology and Hepatology

journal
https://read.qxmd.com/read/31706062/efficacy-of-retreatment-after-failed-direct-acting-antiviral-therapy-in-patients-with-hcv-genotype-1-3-infections
#1
Julia Dietz, Ulrich Spengler, Beat Müllhaupt, Julian Schulze Zur Wiesch, Felix Piecha, Stefan Mauss, Barbara Seegers, Holger Hinrichsen, Christoph Antoni, Perdita Wietzke-Braun, Kai-Henrik Peiffer, Annemarie Berger, Katrin Matschenz, Peter Buggisch, Johanna Backhus, Eugen Zizer, Tobias Boettler, Christoph Neumann-Haefelin, David Semela, Rudolf Stauber, Thomas Berg, Christoph Berg, Stefan Zeuzem, Johannes Vermehren, Christoph Sarrazin
No abstract text is available yet for this article.
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31706061/an-unusual-cause-of-a-common-duodenal-pathology
#2
Marc Monachese, Christophe Langlois, Lawrence Cohen
No abstract text is available yet for this article.
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31706060/clinical-evaluation-of-a-single-use-duodenoscope-for-endoscopic-retrograde-cholangiopancreatography
#3
V Raman Muthusamy, Marco J Bruno, Richard A Kozarek, Bret T Petersen, Douglas K Pleskow, Divyesh V Sejpal, Adam Slivka, Joyce A Peetermans, Matthew J Rousseau, Gregory P Tirrell, Andrew S Ross
BACKGROUND & AIMS: Single-use duodenoscopy is one strategy to decrease infectious outbreaks associated with endoscope reuse. The aim of this study was to test the feasibility, preliminary safety and performance of a new single-use duodenoscope in a clinical setting. METHODS: We conducted a multicenter case series of ERCP using a single-use duodenoscope from April to May 2019. Patients aged 18 years and older without altered pancreaticobiliary anatomy were consecutively screened at 6 academic medical centers, and eligible patients were enrolled...
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31706059/covering-the-year-in-cgh-2019
#4
EDITORIAL
Fasiha Kanwal
No abstract text is available yet for this article.
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31706058/foreign-body-foils-and-follies
#5
Amanda B Siegel, Leila Kia
No abstract text is available yet for this article.
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31706057/nutritional-risks-in-adolescents-after-bariatric-surgery
#6
Stavra A Xanthakos, Jane C Khoury, Thomas H Inge, Todd M Jenkins, Avani C Modi, Marc P Michalsky, Mike K Chen, Anita P Courcoulas, Carroll M Harmon, Mary L Brandt, Michael A Helmrath, Heidi J Kalkwarf
BACKGROUND & AIMS: Little is known about prevalence and risk factors for nutritional deficiencies in adolescents after metabolic bariatric surgery. We performed a 5-year prospective cohort study of these. METHODS: Adolescents who had Roux-en-Y gastric bypass (RYGB, n=161) or vertical sleeve gastrectomy (VSG, n=67) were enrolled at 5 tertiary-care centers from March 2007 through February 2012. The final analysis cohort included 226 participants (161 who had RYGB and 65 who had VSG)...
November 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31704355/electronic-image-of-the-month-underwater-colonoscopic-diagnosis-of-an-unusual-colonic-lesion
#7
Hsu-Heng Yen, Yang-Yuan Chen
No abstract text is available yet for this article.
November 5, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31683059/world-wide-prevalence-of-substitutions-in-hcv-genome-associated-with-resistance-to-direct-acting-antiviral-agents
#8
Zhenqiu Liu, Xianhua Mao, Jiaqi Wu, Kangkang Yu, Qin Yang, Chen Suo, Ming Lu, Li Jin, Tiejun Zhang, Xingdong Chen
BACKGROUND & AIMS: The efficacy of direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) infection can be compromised by substitutions in the HCV genome that occur before treatment (resistance-associated substitutions, RAS). We performed a meta-analysis to determine the prevalence of RASs and their effects. METHODS: We searched publication databases for studies of HCV RNA substitutions that mediate resistance to DAAs. Findings from 50 studies of the prevalence of RAS in HCV, from 32 countries, were used in a meta-analysis...
November 1, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31683058/changes-in-liver-stiffness-measured-by-magnetic-resonance-elastography-associated-with-hepatic-decompensation-in-patients-with-primary-sclerosing-cholangitis
#9
John E Eaton, Aditi Sen, Safa Hoodeshenas, Cathy D Schleck, William S Harmsen, Gregory J Gores, Nicholas F LaRusso, Andrea A Gossard, Konstantinos N Lazaridis, Sudhakar K Venkatesh
BACKGROUND & AIMS: Single measurements of liver stiffness (LS) by magnetic resonance elastography (MRE) have been associated with outcomes of patients with primary sclerosing cholangitis (PSC), but the significance of changes in LS over time are unclear. We investigated associations between changes in LS measurement and progression of PSC. METHODS: We performed a retrospective review of 204 patients with patients who underwent 2 MREs at a single center between January 1, 2007 and December 31, 2018...
November 1, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31683057/efficacy-and-tolerability-of-high-vs-low-volume-split-dose-bowel-cleansing-regimens-for-colonoscopy-a-systematic-review-and-meta-analysis
#10
REVIEW
Marco Spadaccini, Leonardo Frazzoni, Giuseppe Vanella, James East, Franco Radaelli, Cristiano Spada, Lorenzo Fuccio, Robert Benamouzig, Raf Bisschops, Michael Bretthauer, Evelien Dekker, Mario Dinis-Ribeiro, Monika Ferlitsch, Ian Gralnek, Rodrigo Jover, Michal F Kaminski, Maria Pellisé, Konstantinos Triantafyllou, Jeanin E Van Hooft, Jean-Marc Dumonceau, Clelia Marmo, Sergio Alfieri, Viveksandeep Thoguluva Chandrasekar, Prateek Sharma, Doug K Rex, Alessandro Repici, Cesare Hassan
BACKGROUND & AIMS: Efficacy of bowel preparation is an important determinant of outcomes of colonoscopy. It is not clear whether approved low-volume polyethylene glycol (PEG) and non-PEG regimens are as effective as high-volume PEG regimens when taken in a split dose. METHODS: In a systematic review of multiple electronic databases through January 31, 2019 with a registered protocol (PROSPERO: CRD42019128067), we identified randomized controlled trials that compared low- vs high-volume bowel cleansing regimens, administered in a split dose, for colonoscopy...
November 1, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31683056/risk-for-chronic-kidney-disease-in-patients-with-inflammatory-bowel-diseases-increases-with-age-but-is-not-associated-with-5-aminosalicylate-use
#11
Ravy K Vajravelu, Lawrence Copelovitch, Mark T Osterman, Frank I Scott, Ronac Mamtani, James D Lewis, Michelle R Denburg
BACKGROUND & AIMS: It is not clear what factors affect risk of chronic kidney disease (CKD) in patients with inflammatory bowel disease (IBD); increased risk has been inconsistently associated with use of 5-aminosalicylates (5-ASAs). We aimed to calculate the relative hazard of CKD among patients with IBD, adjusted for CKD risk factors, and to determine whether IBD medications are associated with change in estimated glomerular filtration rate (eGFR). METHODS: We performed a retrospective cohort study of data from The Health Improvement Network...
November 1, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31678604/nothing-but-net-a-case-of-neuroendocrine-tumor-in-the-duodenal-bulb
#12
Michelle Baliss, Mohammad Bilal, Sheharyar Merwat
No abstract text is available yet for this article.
October 31, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31678603/laparoscopic-magnetic-sphincter-augmentation-potential-applications-and-safety-are-becoming-more-clear-but-the-story-is-not-over
#13
EDITORIAL
Joel E Richter
No abstract text is available yet for this article.
October 31, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31678602/cost-effectiveness-analysis-of-screening-for-hepatitis-b-virus-infection-in-patients-with-solid-tumors-before-initiating-chemotherapy
#14
Gauree G Konijeti, Sirisha Grandhe, Monica Konerman, Jill Lane, Mark Shrime, Siddharth Singh, Rohit Loomba
BACKGROUND & AIMS: Patients with solid tumors who undergo chemotherapy have an increased risk of hepatitis B virus (HBV) reactivation, but a low proportion of these patients are screened for HBV infection and guidelines make conflicting recommendations. Further, the cost-effectiveness of newer treatments for HBV prophylaxis has not been examined for this population. We aimed to analyze the cost-effectiveness of HBV screening before chemotherapy for patients with solid tumors. METHODS: We compared 3 HBV screening strategies (screen all, screen only high-risk patients, or screen none) using a Markov model of a population of adults in the United States who initiated chemotherapy for a solid tumor...
October 31, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31678201/surveillance-endoscopy-in-the-management-of-hereditary-diffuse-gastric-cancer-syndrome
#15
LETTER
Madeline Friedman, Tomer Adar, Devanshi Patel, Gregory Y Lauwers, Sam S Yoon, John T Mullen, Daniel C Chung
No abstract text is available yet for this article.
October 30, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31676360/positioning-therapies-in-the-management-of-crohn-s-disease
#16
Nghia H Nguyen, Siddharth Singh, William J Sandborn
In the last decade, several new therapies with different mechanisms of action have been approved for the management of moderate to severe Crohn's disease (CD). However, there is limited guidance on optimal positioning of agents as first- or second-line therapies due to the absence of head-to-head trials. Furthermore, given the lack of comparative studies, treatment guidelines provide limited insight. In this review, we will discuss data on key treatment attributes, comparative efficacy and safety, factors predictive of response to each agent and propose an algorithm for positioning therapies for the management of patients with low-risk and high-risk CD...
October 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31676359/gene-variants-that-affect-levels-of-circulating-tumor-markers-increase-identification-of-patients-with-pancreatic-cancer
#17
Toshiya Abe, Chiho Koi, Shiro Kohi, Ki-Byung Song, Koji Tamura, Anne Macgregor-Das, Naoki Kitaoka, Miguel Chuidian, Madeline Ford, Mohamad Dbouk, Michael Borges, Jin He, Richard Burkhart, Christopher L Wolfgang, Alison P Klein, James R Eshleman, Ralph H Hruban, Marcia Irene Canto, Michael Goggins
BACKGROUND & AIMS: Levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and CA-125 in blood are used as markers to determine response of patients with cancer to therapy, but are not used to identify patients with pancreatic cancer. METHODS: We obtained blood samples from 504 patients undergoing pancreatic surveillance from 2002 through 2018 who did not develop pancreatic cancer and measured levels of the tumor markers CA19-9, CEA, CA125, and thrombospondin-2...
October 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31676358/incorporating-high-value-care-into-gastroenterology-fellowship-training
#18
Brijen J Shah, Janice H Jou
No abstract text is available yet for this article.
October 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31676357/good-news-about-bad
#19
EDITORIAL
Lawrence R Schiller
No abstract text is available yet for this article.
October 29, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31676356/levels-of-vitamin-d-are-low-before-or-after-crohn-s-disease-is-established
#20
LETTER
Cong Dai, Min Jiang
No abstract text is available yet for this article.
October 29, 2019: Clinical Gastroenterology and Hepatology
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