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Clinical Gastroenterology and Hepatology

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https://read.qxmd.com/read/30876964/comparative-risk-of-serious-infections-with-biologic-and-or-immunosuppressive-therapy-in-patients-with-inflammatory-bowel-diseases-a-systematic-review-and-meta-analysis
#1
REVIEW
Siddharth Singh, Antonio Facciorusso, Parambir S Dulai, Vipul Jairath, William J Sandborn
BACKGROUND & AIMS: We performed a systematic review and meta-analysis to evaluate the comparative risk of serious infections with tumor necrosis factor (TNF) antagonists, non-TNF targeted biologics, tofacitinib, and immunosuppressive agents in patients with inflammatory bowel diseases (IBD). METHODS: In a systematic search of publications, through March 18, 2018, we identified 15 observational studies (>500 person-years) of patients with IBD treated with TNF antagonists, non-TNF targeted biologics, tofacitinib, and/or immunosuppressive agents (thiopurines, methotrexate) that reported risk of serious infections...
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876963/crohn-s-disease-is-associated-with-an-increased-prevalence-of-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-using-magnetic-resonance-proton-density-fat-fraction-mapping
#2
Scott McHenry, Yeshika Sharma, Ankita Tirath, Richard Tsai, Aaron Mintz, Tyler J Fraum, Amber Salter, Jeffrey D Browning, Avegail G Flores, Nicholas O Davidson, Kathryn J Fowler, Matthew A Ciorba, Parakkal Deepak
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876962/putting-the-horse-back-in-the-barn-right-sizing-use-of-anesthesia-assistance-for-routine-gastrointestinal-endoscopy
#3
EDITORIAL
Megan A Adams
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876961/black-esophagus-a-rare-cause-of-upper-gastrointestinal-bleeding
#4
Blake A Jacobs, George A Salem, Donald J Kastens
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876960/utility-of-genetic-testing-in-persons-with-multiple-colorectal-polyps
#5
EDITORIAL
Natalia Khalaf, Niloy Jewel Samadder
No abstract text is available yet for this article.
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30876959/optimizing-use-of-nonalcoholic-fatty-liver-disease-fibrosis-score-fibrosis-4-score-and-liver-stiffness-measurement-to-identify-patients-with-advanced-fibrosis
#6
Wah-Kheong Chan, Sombat Treeprasertsuk, George Boon-Bee Goh, Jian-Gao Fan, Myeong Jun Song, Phunchai Charatcharoenwitthaya, Ajay Duseja, Yock-Young Dan, Kento Imajo, Atsushi Nakajima, Khek-Yu Ho, Khean-Lee Goh, Vincent Wai-Sun Wong
BACKGROUND & AIMS: Measuring liver stiffness in only patients with indeterminate or high nonalcoholic fatty liver disease (NAFLD) fibrosis scores (called a 2-step approach) was reported to reduce indeterminate or discordant results while maintaining the accuracy to identify patients with advanced fibrosis. We aimed to validate this approach using data collected from the Gut and Obesity in Asia Workgroup. METHODS: We performed a retrospective analysis of data from 759 patients with biopsy-proven NAFLD (24% with advanced fibrosis), seen at 10 centers in 9 countries in Asia, from 2006 through 2018...
March 12, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853617/patients-who-undergo-colectomy-for-pediatric-ulcerative-colitis-at-low-volume-hospitals-have-more-complications
#7
Matthew D Egberg, Joseph A Galanko, Michael D Kappelman
BACKGROUND & AIMS: Adults with ulcerative colitis (UC) who undergo colectomy at high-volume centers have better outcomes and fewer complications than those at low-volume centers. We aimed to evaluate hospital volume of total abdominal colectomy (TAC) for pediatric patients with UC and explore time trends in the proportion of colectomies performed at high-volume centers. We then evaluated the association between hospital colectomy volume and complications. METHODS: We performed a cross-sectional analysis of pediatric patients (≤18 years) hospitalized for UC using the Kids' Inpatient Database (KID), a nationally representative database of pediatric hospitalizations...
March 7, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853616/clinical-practice-guideline-for-the-management-of-luminal-crohn-s-disease-the-toronto-consensus
#8
Remo Panaccione, A Hillary Steinhart, Brian Bressler, Reena Khanna, John K Marshall, Laura Targownik, Waqqas Afif, Alain Bitton, Mark Borgaonkar, Usha Chauhan, Brendan Halloran, Jennifer Jones, Erin Kennedy, Grigorios I Leontiadis, Edward V Loftus, Jonathan Meddings, Paul Moayyedi, Sanjay Murthy, Sophie Plamondon, Greg Rosenfeld, David Schwartz, Cynthia H Seow, Chadwick Williams, Charles N Bernstein
BACKGROUND & AIMS: Crohn's disease (CD) is a lifelong illness with substantial morbidity, although new therapies and treatment paradigms have been developed. We provide guidance for treatment of ambulatory patients with mild to severe active luminal CD. METHODS: We performed a systematic review to identify published studies of the management of CD. The quality of evidence and strength of recommendations were rated according to the Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach...
March 7, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853615/mortality-associated-with-development-of-squamous-cell-cancer-in-patients-with-inflammatory-bowel-disease-receiving-treatment-with-thiopurines
#9
Nabeel Khan, Helen Lee, Chinmay Trivedi, Himanshu Kavani, Elina Medvedeva, Dawei Xie, James D Lewis, Yu-Xiao Yang
BACKGROUND & AIMS: Treatment with thiopurines is associated with an increased risk of squamous cell carcinoma of the skin (SCC) in patients with inflammatory bowel diseases (IBD). We studied outcomes of patients with IBD who developed SCC while receiving thiopurine therapy. METHODS: We conducted a retrospective cohort study of 54,919 patients with IBD followed in the nationwide Veterans Affairs Healthcare System from January 1, 2000 through May 23, 2018. From this cohort, we created a sub-cohort of patients with an incident diagnosis of SCC, confirmed by review of patients' medical records; we identified those who had received treatment with thiopurines (exposed group) vs those treated with 5-ASA and no prior exposure to thiopurines or tumor necrosis factor antagonists (unexposed group)...
March 7, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30853614/unexplained-symptoms-and-hidden-inflammation-in-patients-with-crohn-s-disease
#10
LETTER
D Sorrentino, V Q Nguyen
No abstract text is available yet for this article.
March 7, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30851477/concentrations-of-ustekinumab-during-induction-therapy-associate-with-remission-in-patients-with-crohn-s-disease
#11
Ninon Soufflet, Gilles Boschetti, Xavier Roblin, Charlotte Cuercq, Nicolas Williet, Anne-Laure Charlois, Remi Duclaux-Loras, Pauline Danion, Anne Mialon, Mathias Faure, Stéphane Paul, Bernard Flourie, Stéphane Nancey
No abstract text is available yet for this article.
March 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30851476/effect-of-imperfect-compliance-with-instructions-for-fecal-sample-collection-on-diagnostic-performance-of-9-fecal-immunochemical-tests
#12
Anton Gies, Laura Fiona Gruner, Petra Schrotz-King, Hermann Brenner
BACKGROUND & AIMS: Fecal immunochemical tests (FITs) measure hemoglobin in stool to identify individuals at risk for colorectal cancer (CRC). However, there are many different FITs, with different instructions for fecal sample collection. In routine practice, participants do not always exactly follow these instructions. We assessed the effects of violations of fecal sampling instructions on the diagnostic performance of 9 quantitative FITs. METHODS: We obtained stool samples from 76 patients with CRC scheduled for surgery at 4 hospitals in Germany and 100 participants without advanced neoplasms who participated in a prospective colonoscopy screening program...
March 6, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30849517/cost-effectiveness-of-endoscopic-resection-vs-transanal-resection-of-complex-benign-rectal-polyps
#13
Jessica X Yu, W Alton Russell, Jack H Ching, Nathan Kim, Eran Bendavid, Douglas K Owens, Tonya Kaltenbach
BACKGROUND & AIMS: Complex benign rectal polyps can be managed with transanal surgery or with endoscopic resection (ER). Though the complication rate after ER is lower than transanal surgery, recurrence is higher. Patients lost to follow up after ER might therefore be at increased risk for rectal cancer. We evaluated the costs, benefits, and cost effectiveness of ER compared to 2 surgical techniques for removing complex rectal polyps, using a 50-year time horizon-this allowed us to capture rates of cancer development among patients lost from follow-up surveillance...
March 5, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30831219/value-based-pricing-for-rifaximin-increases-access-of-patients-with-irritable-bowel-syndrome-with-diarrhea-to-therapy
#14
Eric D Shah, Sameer D Saini, William D Chey
BACKGROUND & AIMS: Increasing drug prices lead to payer coverage restrictions, which limit to therapy. We assessed the cost effectiveness of rifaximin in management of patients with irritable bowel syndrome with diarrhea (IBS-D) under common payer coverage restrictions and determined the maximum price at which rifaximin would be cost effective using contemporary cost-effectiveness thresholds. METHODS: A decision analytic model was constructed to evaluate quality of life, cost, and cost effectiveness of rifaximin for patients with IBS-D and complete noncoverage (insurer pays none of the drug cost), unrestricted access (insurer pays 100% of the drug cost), and formulary-restricted access (insurer pays 100% of the drug cost after for patients failed by initial therapy)...
March 1, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30826438/obscure-gastrointestinal-hemorrhage-secondary-to-meckel-s-diverticulum-diagnosed-by-retrograde-double-balloon-enteroscopy
#15
Kevork Khadarian, Ara B Sahakian
No abstract text is available yet for this article.
February 28, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30826437/a-presumed-double-appendiceal-orifice-diagnosis-of-an-appendico-cecal-fistula
#16
Michiel Bronswijk, Paul Christiaens, Veerle Moons
No abstract text is available yet for this article.
February 28, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30826320/correction
#17
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30826319/correction
#18
(no author information available yet)
No abstract text is available yet for this article.
February 28, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30825530/a-rare-cause-of-ileus-in-a-middle-aged-japanese-woman
#19
Tomoya Iida, Yoshiaki Arimura, Hiroshi Nakase
No abstract text is available yet for this article.
February 27, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/30825529/chilaiditi-s-syndrome-post-colonoscopy
#20
Grazia Bernui, Martin Tagle
No abstract text is available yet for this article.
February 27, 2019: Clinical Gastroenterology and Hepatology
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