journal

Clinical Gastroenterology and Hepatology

journal
https://read.qxmd.com/read/32220613/persistent-diarrhea-in-patients-with-crohn-s-disease-after-mucosal-healing-is-associated-with-lower-diversity-of-the-intestinal-microbiome-and-increased-dysbiosis
#1
Karen Boland, Larbi Bedrani, Williams Turpin, Boyko Kabakchiev, Joanne Stempak, Krzysztof Borowski, Geoffrey Nguyen, A Hillary Steinhart, Michelle I Smith, Kenneth Croitoru, Mark S Silverberg
BACKGROUND & AIMS: In patients with inflammatory bowel diseases (IBD), symptoms do not always associate with the severity of endoscopic inflammation and can persist after mucosal healing. We investigated whether symptoms in patients with successfully treated IBD are related to composition of the intestinal microbiome. METHODS: We analyzed 590 tissue biopsies from 215 patients with IBD and 48 healthy individuals (controls). We obtained mucosal biopsies from 2 colon sites (ascending and rectosigmoid) and from the terminal ileum along with clinical data...
March 24, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32217153/a-decade-of-gi-marketing%C3%A2-has-anything-changed
#2
Reed B Hogan, Beth Hogan
No abstract text is available yet for this article.
March 23, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32217152/real-world-gluten-exposure-in-patients-with-celiac-disease-on-gluten-free-diets-determined-from-gliadin-immunogenic-peptides-in-urine-and-fecal-samples
#3
Juan Pablo Stefanolo, Martín Tálamo, Samanta Dodds, María de la Paz Temprano, Ana Florencia Costa, María Laura Moreno, María Inés Pinto-Sánchez, Edgardo Smecuol, Horacio Vázquez, Andrea Gonzalez, Sonia Isabel Niveloni, Eduardo Mauriño, Elena F Verdu, Julio César Bai
BACKGROUND & AIMS: It is not clear how often patients who are on gluten-free diets (GFDs) for treatment celiac disease are still exposed to gluten. We studied levels of gluten immunogenic peptides (GIP) in fecal and urine samples, collected over 4 weeks, from patients with celiac disease following a long-term GFD. METHODS: We performed a prospective study of 53 adults with celiac disease who had been on a GFD for more than 2 years (median duration, 8 years; interquartile range, 5-12 years) in Argentina...
March 23, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205226/lusutrombopag-is-safe-and-efficacious-for-treatment-of-thrombocytopenia-in-patients-with-and-without-hepatocellular-carcinoma
#4
Naim Alkhouri, Michio Imawari, Namiki Izumi, Yukio Osaki, Toshimitsu Ochiai, Takeshi Kano, Roy Bentley, Franco Trevisani
BACKGROUND & AIMS: Patients with hepatocellular carcinoma (HCC) secondary to chronic liver disease often require invasive procedures, but frequently have thrombocytopenia. Lusutrombopag is an agonist of the thrombopoietin receptor that activates platelet production. METHODS: We performed an integrated analysis of data from 2 phase 3 trials (L-PLUS 1, Japan, October 2013 to May 2014 and L-PLUS 2, global, June 2015 to April 2017) that compared efficacy and safety of lusutrombopag to placebo in patients with chronic liver disease, with and without HCC...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205225/methotrexate-associated-lymphoproliferative-disorder-of-the-small-intestine
#5
Hisashi Shiga, Izuru Abe, Atsushi Masamune
No abstract text is available yet for this article.
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205224/palmar-xanthomata-in-a-resolving-cholestatic-liver-injury
#6
Mark R Pedersen, Robert J Fontana, William M Lee
No abstract text is available yet for this article.
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205223/reply-to-the-editor-s-comment
#7
LETTER
Alain Braillon
No abstract text is available yet for this article.
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205222/minimal-hepatic-encephalopathy-and-mild-cognitive-impairment-worsen-quality-of-life-in-elderly-patients-with-cirrhosis
#8
Jasmohan S Bajaj, Andres Duarte-Rojo, Jesse J Xie, Chathur Acharya, James Wade, Carlos Robles, Leroy R Thacker, Christopher Flud, Andrew Fagan, Mauricio Garcia-Saenz-de-Sicilia, Melanie B White, Megan Kelly, Vy Nguyen, Edith A Gavis, Hugo E Vargas
BACKGROUND & AIMS: Patients with cirrhosis are growing older. The overlap between minimal hepatic encephalopathy (MHE) and pre-dementia mild cognitive impairment (MCI) could affect quality of life (QOL). We investigated the performance of elderly patients with cirrhosis on tests for MHE and MCI and their effects on QOL. METHODS: We recruited outpatients with cirrhosis (n=109) and without cirrhosis (controls, n=100), 65 y or older, at 4 centers (derivation cohort)...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205221/long-term-efficacy-and-tolerability-of-rpc4046-in-an-open-label-extension-trial-of-patients-with-eosinophilic-esophagitis
#9
Evan S Dellon, Margaret H Collins, Marc E Rothenberg, Yehudith Assouline-Dayan, Larry Evans, Sandeep Gupta, Alain Schoepfer, Alex Straumann, Ekaterina Safroneeva, Cristian Rodriguez, Neil Minton, Steven Y Hua, Ikuo Hirano
BACKGROUND & AIMS: The short-term efficacy of RPC4046, a monoclonal antibody against interleukin-13, has been demonstrated in patients with eosinophilic esophagitis (EoE). We investigated the long-term efficacy and safety of RPC4046 in an open-label, long-term extension (LTE) study in adults with EoE. METHODS: We analyzed data from 66 patients who completed the 16-week double-blind induction portion of a phase 2 study of RPC4046 (180 mg or 360 mg/weekly) vs placebo and then completed a 52-week LTE, receiving open-label RPC4046 360 mg/weekly...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205220/don-t-overlook-digestive-symptoms-in-patients-with-2019-novel-coronavirus-disease-covid-19
#10
Shihua Luo, Xiaochun Zhang, Haibo Xu
No abstract text is available yet for this article.
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205219/low-but-long-lasting-risk-of-reversal-of-seroconversion-in-patients-with-rheumatoid-arthritis-receiving-immunosuppressive-therapy
#11
Ming-Han Chen, Ming-Huang Chen, Chung-Tei Chou, Ming-Chih Hou, Chang-Youh Tsai, Yi-Hsiang Huang
BACKGROUND & AIMS: In patients who have resolved hepatitis B virus (HBV) infection, treatment of rheumatoid arthritis (RA) can result in reappearance of hepatitis B surface antigen (HBsAg), called reverse seroconversion. We investigated clinical features and outcomes of reverse seroconversion in patients who received immunosuppressant or biologic therapy for RA. METHODS: We identified 1494 patients with RA (925 who resolved HBV infection) and available data on levels of antibody to HB core antigen and HBsAg who had attended Taipei Veterans General Hospital from January 2007 through December 2017...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205218/deep-convolutional-neural-network-aided-detection-of-portal-hypertension-in-patients-with-cirrhosis
#12
Yanna Liu, Zhenyuan Ning, Necati Örmeci, Weimin An, Qian Yu, Kangfu Han, Yifei Huang, Dengxiang Liu, Fuquan Liu, Zhiwei Li, Huiguo Ding, Hongwu Luo, Changzeng Zuo, Changchun Liu, Jitao Wang, Chunqing Zhang, Jiansong Ji, Wenhui Wang, Zhiwei Wang, Weidong Wang, Min Yuan, Lei Li, Zhongwei Zhao, Guangchuan Wang, Mingxing Li, Qingbo Liu, Junqiang Lei, Chuan Liu, Tianyu Tang, Seray Akçalar, Emrecan Çelebioğlu, Evren Üstüner, Sadık Bilgiç, Zeynep Ellik, Özgün Ömer Asiller, Zaiyi Liu, Gaojun Teng, Yaolong Chen, Jinlin Hou, Xun Li, Xiaoshun He, Jiahong Dong, Jie Tian, Ping Liang, Shenghong Ju, Yu Zhang, Xiaolong Qi
BACKGROUND & AIMS: Non-invasive and accurate methods are needed to identify patients with clinically significant portal hypertension (CSPH). We investigated the ability of deep convolutional neural network (CNN) analysis of computed tomography (CT) or magnetic resonance (MR) to identify patients with CSPH. METHODS: We collected liver and spleen image from patients who underwent contrast-enhanced CT or MR analysis within 14 days of transjugular catheterization for hepatic venous pressure gradient measurement...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205217/normal-functional-luminal-imaging-probe-panometry-findings-associate-with-lack-of-major-esophageal-motility-disorder-on-high-resolution-manometry
#13
Alexandra J Baumann, Erica N Donnan, Joseph R Triggs, Wenjun Kou, Jacqueline Prescott, Alex Decorrevont, Emily Dorian, Peter J Kahrilas, John E Pandolfino, Dustin A Carlson
BACKGROUND & AIMS: A normal esophageal response to distension on functional luminal imaging probe (FLIP) panometry during endoscopy might indicate normal esophageal motor function. We aimed to investigate the correlation of normal FLIP panometry findings with esophageal high-resolution manometry (HRM) and outcomes of discrepant patients. METHODS: We performed a retrospective study using data from a registry of patients who completed FLIP during sedated endoscopy...
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32205216/visualization-of-buried-bumper-syndrome-with-upper-endoscopy
#14
Michael Makar, Evan Orosz, Anish Vinit Patel
No abstract text is available yet for this article.
March 20, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200090/sloughing-mucosa-in-esophagitis-dissecans-superficialis
#15
Evan Orosz, Anish Vinit Patel
No abstract text is available yet for this article.
March 18, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200089/esophageal-angiolipoma%C3%AF-a-tongue-like-mucosal-mass
#16
Jun Yi, Xiaowei Liu, Fujun Li
No abstract text is available yet for this article.
March 18, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200088/hepatocellular-carcinoma-unraveling-the-role-of-occult-hepatitis-b-virus-infection
#17
LETTER
Ângelo Z Mattos, Angelo A Mattos, Jose D Debes
No abstract text is available yet for this article.
March 18, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200087/cumulative-exposure-to-infliximab-but-not-trough-concentrations-correlate-with-rate-of-infection
#18
Amandine Landemaine, Antoine Petitcollin, Charlène Brochard, Céline Miard, Marie Dewitte, Eric Le Balc'h, Thomas Grainville, Eric Bellissant, Laurent Siproudhis, Guillaume Bouguen
BACKGROUND & AIMS: Infliximab increases the risk of infection in patients with inflammatory bowel diseases (IBD), but there is controversy over the relationship between drug concentration and infections. We aimed to assess factors associated with infection in infliximab-treated patients, including pharmacokinetic features. METHODS: We collected data from 209 patients with IBD (102 men; mean age, 39 y; 159 with Crohn's disease; 54 received combination therapy) who received a infliximab maintenance regimen from November 2016 through April 2017 in France...
March 18, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200086/response-to-letter-to-the-editor
#19
LETTER
Erwin Dreesen, Geert D'Haens, David Laharie, Séverine Vermeire
No abstract text is available yet for this article.
March 18, 2020: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/32200085/assessment-of-liver-fibrosis-with-elastography-point-quantification-vs-transient-elastography
#20
LETTER
Niek Warringa, Egbert-Jan van der Wouden, Madelon Bruggemann Gaasbeek, Lida J Dam-Vervloet, Martijn F Boomsma
No abstract text is available yet for this article.
March 18, 2020: Clinical Gastroenterology and Hepatology
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