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REVIEW
Kai En Chan, Elden Yen Hng Ong, Charlotte Hui Chung, Christen En Ya Ong, Benjamin Koh, Darren Jun Hao Tan, Wen Hui Lim, Jie Ning Yong, Jieling Xiao, Zhen Yu Wong, Nicholas Syn, Apichat Kaewdech, Margaret Teng, Jiong-Wei Wang, Nicholas Chew, Dan Yock Young, Alfred Kow, Mohammad Shadab Siddiqui, Daniel Q Huang, Nobuharu Tamaki, Vincent Wai-Sun Wong, Christos S Mantzoros, Arun Sanyal, Mazen Noureddin, Cheng Han Ng, Mark Muthiah
BACKGROUND AND AIMS: The progression of MASLD has been found to manifest in a series of hepatic and extra-hepatic complications. A comprehensive meta-analysis of the longitudinal outcomes associated with MASLD has yet to be conducted. METHODS: To investigate the longitudinal outcomes associated with MASLD, Medline and Embase databases were searched to identify original studies which evaluated the longitudinal risks of incident clinical outcomes among MASLD patients compared with non-MASLD individuals...
September 27, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Naohisa Yoshida, Yoshikazu Hayashi, Daichi Togo, Shiro Oka, Kazunori Takada, Shusei Fukunaga, Yoshinori Morita, Takemasa Hayashi, Kazuhiro Kozuka, Yosuke Tsuji, Takashi Murakami, Takeshi Yamamura, Yoriaki Komeda, Yoji Takeuchi, Kensuke Shinmura, Hiroko Fukuda, Shinji Yoshii, Shoko Ono, Shinichi Katsuki, Kazumasa Kawashima, Daiki Nemoto, Hiroyuki Yamamoto, Yutaka Saito, Naoto Tamai, Aya Iwao, Yuki Itoi, Shigetsugu Tsuji, Yoshikazu Inagaki, Yutaka Inada, Koichi Soga, Daisuke Hasegawa, Takaaki Murakami, Hiroyuki Yoriki, Kohei Fukumoto, Takayuki Motoyoshi, Yasuki Nakatani, Yasushi Sano, Mikitaka Iguchi, Shigehiko Fujii, Hiromitsu Ban, Keita Harada, Koichi Okamoto, Hitoshi Nishiyama, Fumisato Sasaki, Kazujhiro Mizukami, Takashi Shono, Ryo Shimoda, Tadashi Miike, Naoyuki Yamaguchi
BACKGROUND AND AIMS: Reported rates of delayed bleeding (DB) after endoscopic resection using direct oral anticoagulants (DOACs) are high and heterogeneous. This large-scale multicenter study analyzed cases of DB after colorectal endoscopic submucosal dissection related to various types of DOACs in Japan (the ABCD-J study) with those associated with warfarin. METHODS: We retrospectively reviewed 1,019 lesions in patients treated with DOACs and 459 lesions in patients treated with warfarin among 34,455 ESD cases from 47 Japanese institutions between 2012 and 2021...
September 22, 2023: Clinical Gastroenterology and Hepatology
#3
JOURNAL ARTICLE
Pauline Wils, Vipul Jairath, Bruce E Sands, Walter Reinisch, Silvio Danese, Laurent Peyrin-Biroulet
No abstract text is available yet for this article.
September 22, 2023: Clinical Gastroenterology and Hepatology
#4
LETTER
M J Warners, A J Bredenoord
No abstract text is available yet for this article.
September 22, 2023: Clinical Gastroenterology and Hepatology
#5
JOURNAL ARTICLE
Jean-Frederic Colombel, Ryan C Ungaro, Bruce E Sands, Corey A Siegel, Douglas C Wolf, John F Valentine, Brian G Feagan, Blue Neustifter, Harisha Kadali, Pradeep Nazarey, Alexandra James, Vipul Jairath, Rana M Qasim Khan
BACKGROUND & AIMS: Although biologics have revolutionized treatment of Crohn's disease (CD), an efficacy ceiling has been reached. Combining biologic therapies may improve remission rates. METHODS: EXPLORER, a phase 4, single-arm, open-label study, evaluated triple combination therapy with vedolizumab (300 mg on day 1, weeks 2 and 6, then every 8 weeks), adalimumab (160 mg on day 2, 80 mg at week 2, then 40 mg every 2 weeks), and methotrexate (15 mg weekly) in biologic-naïve patients with newly diagnosed, moderate- to high-risk CD...
September 22, 2023: Clinical Gastroenterology and Hepatology
#6
JOURNAL ARTICLE
Grace Berwald, Graeme P Young, Charles Cock, Peter Bampton, Robert Fraser, Erin L Symonds
BACKGROUND AND AIMS: An increasing burden on healthcare resources has resulted in a backlog of individuals requiring colonoscopy, with delays in surveillance possibly detrimental for individuals at increased risk of colorectal cancer (CRC). This study investigated the use of a two-sample fecal immunochemical test (FIT to establish those most likely to have advanced neoplasia (AN) and in need of prioritized surveillance colonoscopy. METHODS: A prospective study conducted in the tertiary care setting...
September 22, 2023: Clinical Gastroenterology and Hepatology
#7
REVIEW
Darren M Brenner, Amy M Ladewski, Sarah Wimberly Kinsinger
BACKGROUND: Irritable bowel syndrome (IBS) is a common, debilitating disorder characterized by abdominal pain and disordered bowel habits. Current pharmacological treatments often provide incomplete symptom relief and may be poorly tolerated. Furthermore, alleviation of gastrointestinal symptoms does not always translate into improved quality of life (QOL) for IBS patients. Current treatment guidelines recommend brain-gut behavior therapy (BGBT) in conjunction with other IBS therapies, and in randomized controlled trials, BGBT has been shown to improve symptoms, patient satisfaction, functioning, and QOL...
September 22, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Andrew Dickerson, Ayse Kolemen, Keeler Kime, Kira Chaiboonma, Ranjan Dohil, Glenn T Furuta, Evan S Dellon, Seema S Aceves
BACKGROUND AND AIMS: The Index of Severity for EoE (I-SEE) was recently developed. We aimed to understand I-SEE scores in a longitudinal pediatric cohort and to determine the relationship between I-SEE and clinical features in children. METHODS: We performed a retrospective analysis on a prospectively enrolled cohort of children at a single center who were treated as part of routine clinical care. I-SEE was calculated at the diagnostic and follow-up endoscopies over a mean of 6...
September 22, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
A Computer-Aided Detection (CADe) System Significantly Improves Polyp Detection in Routine Practice.
Rajesh N Keswani, Urvi Thakkar, Alexandra Sals, John E Pandolfino
No abstract text is available yet for this article.
September 21, 2023: Clinical Gastroenterology and Hepatology
#10
LETTER
James M Paik, Linda Henry, Zobair M Younossi
No abstract text is available yet for this article.
September 21, 2023: Clinical Gastroenterology and Hepatology
#11
LETTER
Fu-Shun Yen, Teng-Shun Yu, Chih-Cheng Hsu, Chii-Min Hwu
No abstract text is available yet for this article.
September 21, 2023: Clinical Gastroenterology and Hepatology
#12
JOURNAL ARTICLE
Yousaf Abughofah, Grace E Kim, Dennis Chen
No abstract text is available yet for this article.
September 21, 2023: Clinical Gastroenterology and Hepatology
#13
REVIEW
Isabelle Mack, Heiko Hahn, Celina Gödel, Paul Enck, Adil E Bharucha
BACKGROUND & AIMS: Fecal incontinence (FI) can considerably impair quality of life. Through a systematic review and meta-analysis, we sought to determine the global prevalence and geographic distribution of FI and to characterize its relationship with sex and age. METHODS: We searched PubMed, Web of Science, and Cochrane Library databases to identify population-based surveys of the prevalence of FI. RESULTS: Of the 5,175 articles identified, the final analysis included 80 studies; the median response rate was 66% (IQR, 54%-74%)...
September 19, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Angela Chau, Ming-Lun Yeh, Pei-Chien Tsai, Daniel Q Huang, Sung Eun Kim, Huy Trinh, Eileen L Yoon, Hyunwoo Oh, Jae Yoon Jeong, Sang Bong Ahn, Jihyun An, Cheng-Hao Tseng, Yao-Chun Hsu, Soung Won Jeong, Yong Kyun Cho, Jae-Jun Shim, Hyoung Su Kim, Takanori Ito, Sebastián Marciano, Keigo Kawashima, Takanori Suzuki, Tsunamasa Watanabe, Akito Nozaki, Toru Ishikawa, Kaori Inoue, Yuichiro Eguchi, Haruki Uojima, Hiroshi Abe, Hirokazu Takahashi, Makoto Chuma, Masatoshi Ishigami, Joseph K Hoang, Maeda Mayumi, Chung-Feng Huang, Adrian Gadano, Chia-Yen Dai, Jee-Fu Huang, Yasuhito Tanaka, Wan-Long Chuang, Seng Gee Lim, Ramsey Cheung, Ming-Lung Yu, Dae-Won Jun, Mindie H Nguyen
BACKGROUND: It is unclear if there may be sex differences in response to nucleos(t)ide analogs (NA) including viral suppression [VR], biochemical response [BR], complete response [CR], and HCC incidence among hepatitis B patients. We compared NA treatment outcomes by sex. APPROACH: A retrospective cohort study of 3388 treatment-naïve adult hepatitis B patients (1250 female; 2138 male) from the REAL-B consortium who initiated therapy with either entecavir or tenofovir from 22 sites (Argentina, Korea, Japan, Taiwan, USA)...
September 19, 2023: Clinical Gastroenterology and Hepatology
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JOURNAL ARTICLE
Yuk Kam Yau, Louis Ho Shing Lau, Rashid Nok Shun Lui, Sunny Hei Wong, Cosmos Liutao Guo, Joyce Wing Yan Mak, Jessica Yuet Ling Ching, Margaret Ip, Michael A Kamm, David T Rubin, Paul Kay Sheung Chan, Francis Ka Leung Chan, Siew Chien Ng
BACKGROUND AND AIMS: Prospective long-term real-world safety data after fecal microbiota transplantation (FMT) remain limited. We reported long-term outcomes of FMT from a population-based FMT registry in Hong Kong. METHODS: We recruited patients undergoing FMT for recurrent Clostridioides difficile infection (CDI) and non-CDI indications from clinical trials, from June 2013 to April 2022 in Hong Kong. We captured data on demographics, FMT indications and procedures, clinical outcomes and short-to-long-term safety...
September 19, 2023: Clinical Gastroenterology and Hepatology
#16
JOURNAL ARTICLE
Aze Wilson, Nilesh Chande, Terry Ponich, James C Gregor, Yun-Hee Choi, Richard B Kim
No abstract text is available yet for this article.
September 19, 2023: Clinical Gastroenterology and Hepatology
#17
JOURNAL ARTICLE
Seung-Ho Sin, Hyung-Keun Kim, Huin-Suk Chae
No abstract text is available yet for this article.
September 18, 2023: Clinical Gastroenterology and Hepatology
#18
LETTER
Ayokunle T Abegunde
No abstract text is available yet for this article.
September 18, 2023: Clinical Gastroenterology and Hepatology
#19
JOURNAL ARTICLE
Mehdi Mohamadnejad, Ali Ali Asgari, Mohammad Al-Haddad
No abstract text is available yet for this article.
September 18, 2023: Clinical Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Diana L Snyder, Evan S Dellon
No abstract text is available yet for this article.
September 15, 2023: Clinical Gastroenterology and Hepatology
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