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Clinical Gastroenterology and Hepatology

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https://read.qxmd.com/read/31100461/severe-ulcerative-skin-lesions-due-to-lenvatinib
#1
Kazufumi Dohmen
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100460/liver-stiffness-severity-is-associated-with-increased-cardiovascular-risk-in-patients-with-type-2-diabetes
#2
Neeraj Mangla, Veeral H Ajmera, Cyrielle Caussy, Claude Sirlin, Sharon Brouha, Sonia Bajwa-Dulai, Egburt Madamba, Ricki Bettencourt, Lisa Richards, Rohit Loomba
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100459/increased-gut-permeability-in-first-degree-relatives-of-children-with-irritable-bowel-syndrome-or-functional-abdominal-pain
#3
Mark McOmber, Danny Rafati, Kevin Cain, Sridevi Devaraj, Erica M Weidler, Margaret Heitkemper, Robert J Shulman
BACKGROUND & AIMS: Increased gut permeability might contribute to the pathogenesis of irritable bowel syndrome or functional abdominal pain (IBS or FAP). We investigated whether siblings and parents of children with IBS or FAP have increased gut permeability. METHODS: We performed permeability tests (using sucrose, lactulose, mannitol, and sucralose) on 29 siblings and 43 parents of children with IBS or FAP, and 43 children (controls) and 42 parents of controls, from primary and secondary care...
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100458/effects-of-vedolizumab-in-patients-with-primary-sclerosing-cholangitis-and-inflammatory-bowel-diseases
#4
Kate D Lynch, Roger W Chapman, Satish Keshav, Aldo J Montano-Loza, Andrew L Mason, Andreas E Kremer, Marcel Vetter, Manon de Krijger, Cyriel Y Ponsioen, Palak Trivedi, Gideon Hirschfield, Christoph Schramm, Chung Heng Liu, Christopher L Bowlus, Derek J Estes, Daniel Pratt, Charlotte Hedin, Annika Bergquist, Annemarie C de Vries, C Janneke van der Woude, Lei Yu, David N Assis, James Boyer, Henriette Ytting, Emina Hallibasic, Michael Trauner, Hanns-Ulrich Marschall, Luigi M Daretti, Marco Marzioni, Kidist K Yimam, Nicola Perin, Annarosa Floreani, Benedetta Terziroli Beretta-Piccoli, Jennifer K Rogers, Cynthia Levy
BACKGROUND & AIMS: Gut-homing lymphocytes that express the integrin α4β7 and CCR9 might contribute to development of primary sclerosing cholangitis (PSC). Vedolizumab, which blocks the integrin α4β7, is used to treat patients with inflammatory bowel diseases (IBD), but there are few data on its efficacy in patients with PSC. We investigated the effects of vedolizumab in a large international cohort of patients with PSC and IBD. METHODS: We collected data from European and North American centers participating in the International PSC Study Group from patients with PSC and IBD who received at least 3 doses of vedolizumab (n=102; median vedolizumab treatment duration, 412 days)...
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100457/submucosal-vascular-malformation-as-the-cause-of-recurrent-obscure-bleed
#5
Michael Bies, Priya Vijayvargiya, Laura Raffals
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100456/variation-among-patients-with-crohn-s-disease-in-benefit-vs-risk-preferences-and-remission-time-equivalents
#6
Meenakshi Bewtra, Shelby D Reed, F Reed Johnson, Frank I Scott, Erin Gilroy, Robert S Sandler, Wenli Chen, James D Lewis
BACKGROUND & AIMS: Patients with Crohn's disease (CD) must make decisions about their treatment. We aimed to quantify patients' preferences for different treatment outcomes and adverse events. We also evaluated the effects of latent-class heterogeneity on these preferences. METHODS: An online stated-preference survey was completed by 812 individuals with CD in the Crohn's and Colitis Foundation Partners cohort (IBD Partners). Patients were given information on symptoms and severity of active disease; duration of therapy with corticosteroids; and risks of serious infection, cancer and surgery...
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100455/efficacy-of-epicutaneous-immunotherapy-in-children-with-milk-induced-eosinophilic-esophagitis
#7
Jonathan M Spergel, Okan U Elci, Amanda B Muir, Chris A Liacouras, Benjamin J Wilkins, Deirdre Burke, Megan O Lewis, Terri Brown-Whitehorn, Antonella Cianferoni
BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is caused by an immune response to specific food allergens. There are no approved therapies beyond avoidance of the allergen(s) or treatment of inflammation. Epicutaneous immunotherapy (EPIT) reduces features of eosinophilic gastrointestinal disease in mice and pigs. We performed randomized, placebo-controlled study to determine the safety and efficacy of EPIT with Viaskin milk in children with milk-induced EoE. METHODS: In a double-blind study, 20 children (4-17 years old) with milk-induced EoE were randomly assigned to groups given EPIT with Viaskin milk (n=15) or placebo (n=5) for 9 months during a milk-free period, followed by milk-containing diet for 2 months with EPIT...
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100454/what-patients-need-to-know-about-living-with-ibd
#8
Lucia V Allen
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100453/kalimate-induced-upper-gastrointestinal-bleeding-in-a-77-year-old-woman
#9
Yi-Hua Wu, Tsung-Wei Chen, Jen-Wei Chou
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100452/endoscopic-mucosal-resection-and-endoscopic-submucosal-dissection-are-complementary-in-the-treatment-of-colorectal-neoplasia
#10
LETTER
Michael J Bourke, Steven J Heitman
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31100451/elephantiasis-and-the-origins-of-chronic-bowel-damage-in-crohn-s-disease
#11
LETTER
Herbert J van Kruiningen, Pietro Tonelli
No abstract text is available yet for this article.
May 14, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31085339/nancy-index-scores-of-chronic-inflammatory-bowel-disease-activity-associate-with-development-of-colorectal-neoplasia
#12
Julien Kirchgesner, Magali Svrcek, Guillaume Le Gall, Cécilia Landman, Xavier Dray, Anne Bourrier, Isabelle Nion-Larmurier, Nadia Hoyeau, Harry Sokol, Philippe Seksik, Jacques Cosnes, Jean-François Fléjou, Laurent Beaugerie
BACKGROUND & AIMS: The degree of histological and endoscopic disease activity has been associated with an increased risk of colorectal neoplasia (CRN) in patients with inflammatory bowel diseases (IBD), but no histological scoring systems have been validated for determining risk of CRN. We investigated the association between histological and endoscopic disease activity and risk of first CRN in patients with IBD who had negative findings from a surveillance colonoscopy. METHODS: We performed a retrospective analysis of consecutive patients who underwent at least 2 colonoscopies at Saint Antoine Hospital in France from January 1, 1996 through March 1, 2015 and whose first procedure was a surveillance colonoscopy...
May 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31085338/lower-abnormal-fecal-immunochemical-test-cutoff-values-improve-detection-of-colorectal-cancer-in-system-level-screens
#13
Emily Berry, Stacie Miller, Mark Koch, Bijal Balasubramanian, Keith Argenbright, Samir Gupta
BACKGROUND & AIMS: Non-invasive tests used in colorectal cancer screening, such as the fecal immunochemical test (FIT), are more acceptable but detect neoplasias with lower levels of sensitivity than colonoscopy. We investigated whether lowering the cutoff concentration of hemoglobin for designation as an abnormal FIT result increased the detection of advanced neoplasia in a mailed outreach program. METHODS: We performed a prospective study of 17,017 uninsured patients, 50-64 years old, who were not current with screening and enrolled in a safety-net system in Texas...
May 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31085337/alcoholic-and-nonalcoholic-fatty-liver-disease-and-incident-hospitalization-for-liver-and-cardiovascular-diseases
#14
Yoosoo Chang, Juhee Cho, Yong Kyun Cho, Ara Cho, Yun Soo Hong, Di Zhao, Jiin Ahn, Chong Il Sohn, Hocheol Shin, Eliseo Guallar, Seungho Ryu
BACKGROUND & AIMS: We compared the associations of nonalcoholic fatty liver disease (NAFLD) and alcohol-associated fatty liver disease (AFLD) with risk of incident hospitalization for liver and cardiovascular diseases. METHODS: We collected data from the Kangbuk Samsung Health Study on 218,030 men and women in Korea who underwent a health examination from 2011 through 2016. Fatty liver disease (FLD) was detected by ultrasound during the initial examination. The fibrosis-4 index was used to identify individuals with liver fibrosis...
May 11, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31078696/physician-practice-management-and-private-equity-market-forces-drive-change
#15
Mark Gilreath, Steven Morris, Joel V Brill
No abstract text is available yet for this article.
May 9, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31077838/daily-aspirin-use-associated-with-reduced-risk-for-fibrosis-progression-in-patients-with-nonalcoholic-fatty-liver-disease
#16
Tracey G Simon, Jacqueline Henson, Stephanie Osganian, Ricard Masia, Andrew T Chan, Raymond T Chung, Kathleen E Corey
BACKGROUND & AIMS: There are few data from prospective studies on the effects of aspirin on fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: We performed a prospective cohort study of 361 adults with biopsy-confirmed NAFLD, from 2006 through 2015, examined every 3-12 months for incident advanced fibrosis defined using serial measurements of validated indices (the Fibrosis-4, NAFLD fibrosis score, and aspartate aminotransferase to platelet ratio indices)...
May 8, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31077837/taenia-solium-in-the-small-intestine
#17
Joshua B Satchwell, Samir C Grover
No abstract text is available yet for this article.
May 8, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31077836/endometriosis-of-the-appendix
#18
Shelini Sooklal, Asyia Ahmad
No abstract text is available yet for this article.
May 8, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31077835/endoscopic-management-of-recurrent-acute-pancreatitis
#19
Liam Zakko, Timothy B Gardner
No abstract text is available yet for this article.
May 8, 2019: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/31077834/transhepatic-peg-tube-placement
#20
Marcel Tomaszewski, Matthew Strohl, Philip Wong
No abstract text is available yet for this article.
May 8, 2019: Clinical Gastroenterology and Hepatology
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