Prasad G Iyer, Seth W Slettedahl, Douglas W Mahoney, Maria Giakoumopoulos, Marilyn C Olson, Martin Krockenberger, William R Taylor, Patrick Foote, Calise Berger, Cadman Leggett, T T Wu, Eduardo Antpack, Gary W Falk, Gregory G Ginsberg, Julian A Abrams, Charles J Lightdale, Francisco Ramirez, Allon Kahn, Herbert Wolfsen, Vani Konda, Arvind J Trindade, John B Kisiel
BACKGROUND AND AIMS: Endoscopic Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Non-endoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort. METHODS: Algorithm training and test samples were from two prospective multicenter cohorts...
March 19, 2024: Clinical Gastroenterology and Hepatology