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Journals Clinical and Experimental Rheu...

Clinical and Experimental Rheumatology

https://read.qxmd.com/read/38757296/red-blood-cell-distribution-width-as-a-surrogate-biomarker-of-damage-and-disease-activity-in-patients-with-systemic-lupus-erythematosus
#1
JOURNAL ARTICLE
Julia Mercader-Salvans, María García-González, Juan Carlos Quevedo-Abeledo, Adrián Quevedo-Rodríguez, Fuensanta Gómez-Bernal, Marta Hernández-Díaz, María Pestana-Eliche, Marcella Markthaler, Candelaria Martín-González, Cristina Gómez-Moreno, Miguel Ángel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Red blood cell distribution width (RDW) is a measure of variability in mean corpuscular volume. Alterations in RDW can be observed in a variety of human disorders, including inflammatory, cardiovascular, and hepatic or renal diseases. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect virtually any organ in the body. In this work, our objective was to analyse how a complete characterisation of disease characteristics in a large series of patients with SLE is related to RDW values...
May 17, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757280/comparison-of-clinical-characteristics-between-patients-with-axial-spondyloarthritis-with-and-without-acute-anterior-uveitis-a-multicentre-study-of-the-chinese-spondyloarthritis-registry
#2
JOURNAL ARTICLE
Simeng Liu, Shangzhu Zhang, Xinwang Duan, Yanhong Wang, Jian Xu, Qin Li, Lijun Wu, Zhenbiao Wu, Min Yang, Shengyun Liu, Linyi Peng, Jinmei Su, Mengtao Li, Xiaofeng Zeng
OBJECTIVES: This study explores the clinical characteristics associated with the occurrence of acute anterior uveitis (AAU) in patients with axial spondyloarthritis (axSpA) within a large, multicentre database. METHODS: This observational, cross-sectional study of patients with axSpA used data from the Chinese Spondyloarthritis Registry between August 1, 2018, and March 31, 2020. The demographic and clinical features of patients with and without AAU were compared...
May 17, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757293/infliximab-for-parenchymal-neuro-beh%C3%A3-et-s-syndrome-case-series-and-meta-analysis
#3
JOURNAL ARTICLE
Xiaoou Wang, Yeling Liu, Yiyuan Ao, Jing Wang, Jinjing Liu, Yan Xu, Wenjie Zheng
OBJECTIVES: This study aims to evaluate the efficacy and safety of infliximab (IFX) in patients with parenchymal neuro-Behçet's syndrome (p-NBS). METHODS: We retrospectively analysed eleven p-NBS patients treated with IFX at our institution and combined them with studies from database searches for a meta-analysis. Pooled estimates of clinical response (complete and partial remission) and MRI improvement at months 3, 6, and 12 were calculated. RESULTS: One patient achieved CR and the other ten patients achieved PR at our institution...
May 15, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757295/exploring-the-link-between-dietary-omega-3-and-omega-6-fatty-acid-intake-and-rheumatoid-arthritis-risk-nhanes-1999-2020-study
#4
JOURNAL ARTICLE
Tianlun Kang, Yajing Xi, Tangliang Qian, Siyi Lu, Mengmeng Du, Xiaojun Shi, Xiujuan Hou
OBJECTIVES: The association between the ingestion of n-3 and n-6 fatty acids and rheumatoid arthritis (RA) remains unclear. To address this, this study utilised data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2020. METHODS: Dietary intake information on n-3 and n-6 fatty acids was gathered through 24-hour interviews about dietary recall and adjusted based on weight. RA patient data was collected using questionnaires...
May 6, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757298/gender-disparity-among-the-academics-of-rheumatology-in-turkey
#5
LETTER
Haluk Cinakli, Gülay Alp
No abstract text is available yet for this article.
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757297/performance-of-a-novel-high-resolution-infrared-thermography-marker-in-detecting-and-assessing-joint-inflammation-a-comparison-with-joint-ultrasound
#6
JOURNAL ARTICLE
Konstantinos Triantafyllias, Marina Clasen, Michele De Blasi, Manfred Berres, Eleftherios Nikolodimos, Andreas Schwarting
OBJECTIVES: To examine the value of a novel high-resolution thermographic marker in the detection of joint inflammation compared to joint ultrasound (US) and to suggest thermographic cut-off values of joint inflammatory activity. METHODS: Infrared thermographies were performed in patients with inflammatory arthritides and healthy controls. Patients were moreover examined clinically and by joint-US [Power-Doppler-(PDUS), Greyscale-US (GSUS)]. Regions of interest (ROIs) were defined for every joint and absolute temperature values within the ROIs were documented...
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757292/real-world-utilisation-and-switching-between-janus-kinase-inhibitors-in-australian-patients-with-rheumatoid-arthritis-in-the-opal-dataset
#7
JOURNAL ARTICLE
Sabina Ciciriello, Geoffrey O Littlejohn, Tamas Treuer, Kathryn A Gibson, Ewa Haladyj, Peter Youssef, Paul Bird, Catherine O'Sullivan, Tegan Smith, Claire T Deakin
OBJECTIVES: To describe use and treatment persistence for Janus kinase inhibitors (JAKi) in rheumatoid arthritis (RA) by line of therapy, and the mechanism of action for the drug switched to after JAKi discontinuation. METHODS: This was a retrospective, observational analysis using the OPAL dataset, a large collection of deidentified electronic medical records from 112 rheumatologists around Australia. Adult patients with RA were included if they initiated tofacitinib (TOF), baricitinib (BARI) or upadacitinib (UPA) between 1 October 2015 and 30 September 2021...
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757290/haptoglobin-blood-assay-to-assess-treatment-compliance-in-rheumatoid-arthitis-patients-treated-with-tocilizumab
#8
LETTER
Pierre-Yves Montagnon, Marine Beauger, Marion Couderc, Anne Tournadre, Martin Soubrier, Sylvain Mathieu
No abstract text is available yet for this article.
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757282/neutrophils-impaired-by-anti-galectin-3-antibodies-elicit-inflammation-of-endothelial-cells-to-aggregate-the-development-of-lupus-cutaneous-vasculitis
#9
JOURNAL ARTICLE
Feng-Qiu Hu, Si-Yao Lu, Zhen-Rui Shi, Yu-Xian Lai, Yan-Ling Ren, Jian Wu, Guo-Zhen Tan, Kang Zeng, Liangchun Wang
OBJECTIVES: To investigate whether the interplay of anti-galectin-3 antibodies (anti-Gal3 Abs) with neutrophils contributes to the development of lupus cutaneous vasculitis. METHODS: Enzyme-linked immunosorbent assay was used to determine the serum level of anti-Gal3 Abs in lupus patients. Flow cytometry, quantitative PCR and western blot were performed to investigate the expression of cell surface receptors, proinflammatory cytokines and signalling molecules in neutrophils stimulated by serum from lupus patients or healthy controls (HCs) or anti-Gal3 Ab, respectively...
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757281/association-between-mycobacterium-tuberculosis-infection-and-the-risk-of-inflammatory-arthritides
#10
JOURNAL ARTICLE
Minkyung Han, Jang Woo Ha, Inkyung Jung, Chi Young Kim, Sung Soo Ahn
OBJECTIVES: Tuberculosis is a highly contagious disease that has a significant impact on global health. Emerging evidence suggests that tuberculosis can lead to an altered immune response. We investigated the association between tuberculosis and the onset of inflammatory arthritides (IA). METHODS: Patients with incident tuberculosis in the South Korean National Claims database from 2010 to 2021 were included, and those who had undergone appendectomy during 2010-2011 served as controls...
May 1, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757283/treat-to-target-and-shared-decision-making-in-systemic-lupus-erythematosus-from-the-patients-perspective-results-from-an-international-patient-survey
#11
JOURNAL ARTICLE
Johanna Mucke, Daliya T Pencheva, Agner R Parra Sánchez, Kyra Cramer, Matthias Schneider, Irene E M Bultink
OBJECTIVES: Treat-to-target (T2T) is being recognised as a promising concept to significantly improve the outcomes of patients with systemic lupus erythematosus (SLE). Despite its success being closely tied to patients' involvement, the patients' perspective regarding T2T has not been evaluated. We aimed to investigate patients' attitude towards T2T and their involvement in treatment decisions. METHODS: We designed a 13-question online survey on T2T, examining acceptance, willingness to participate in T2T trials, and potential obstacles...
April 29, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757299/influence-of-doctor-patient-relationships-and-health-related-factors-on-the-medical-satisfaction-of-patients-with-sj%C3%A3-gren-s-disease
#12
JOURNAL ARTICLE
Kaori Komori, Masahiro Komori, Taro Horino, Susumu Nishiyama, Masami Takei, Narufumi Suganuma
OBJECTIVES: Patients with chronic, incurable conditions rely on their providers to help relieve their symptoms. Dissatisfaction with their care can erode the doctor-patient relationship and reduce the effectiveness of treatment. We investigated the relationships between satisfaction and symptoms, the doctor-patient relationship, and health-related factors in patients with Sjögren's disease (SjD) in Japan. METHODS: Using a questionnaire survey, we evaluated via multinomial logistic regression associations between satisfaction [satisfied, neither (neither satisfied nor dissatisfied), dissatisfied] and symptoms, prescribed medications, anxiety, distress, expectations from treatments, and doctor-patient relationships...
April 19, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38757294/reply-to-fibromyalgia-and-hyperlipidemia-a-balance-between-cardiovascular-risk-reduction-and-muscular-side-effects
#13
LETTER
Valeria Giorgi, Piercarlo Sarzi-Puttini
No abstract text is available yet for this article.
April 18, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38634362/effectiveness-and-safety-of-filgotinib-in-rheumatoid-arthritis-patients-data-from-the-gisea-registry
#14
JOURNAL ARTICLE
Marco Fornaro, Roberto Caporali, Martina Biggioggero, Serena Bugatti, Ludovico De Stefano, Alberto Cauli, Mattia Congia, Fabrizio Conti, Maria Sole Chimenti, Chiara Bazzani, Simone Perniola, Fabiola Atzeni, Giovanni Lapadula, Gianfranco Ferraccioli, Florenzo Iannone
OBJECTIVES: The aim of this study was to evaluate the effectiveness and safety profile of filgotinib, a JAK1 preferential inhibitor, in rheumatoid arthritis (RA) patients included in Italian GISEA (Group for the Study of Early Arthritis) registry. METHODS: Data from RA patients treated with filgotinib, recorded in the GISEA registry, were analysed. Disease activity scores and patient-reported outcomes (PROs) were assessed at baseline, as well as during 12-month follow-up...
April 17, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38634375/lower-total-cholesterol-and-triglyceride-levels-in-ankylosing-spondylitis-than-non-inflammatory-rheumatic-disease-controls-in-a-1978-98-study-a-potential-effect-of-increased-physical-energetics-in-manual-occupations-in-the-pre-2000-chronologic-era
#15
JOURNAL ARTICLE
Alfonse T Masi, Ponnaiah C Mohan, Tsr Murugan, Chadrick R Evans, Michael J Ryan, Megan L Brezka, Vaughn Hanna, Gerald R Cooper, Jean C Aldag
OBJECTIVES: No article on serum lipids in ankylosing spondylitis (AS) and control subjects has been reported from USA. The primary aim of this study was to determine if any difference occurred in serum lipid levels in AS and control rheumatic disorders in two time periods, 1978-98 and 2000-10. The secondary aim was to investigate variables associated with lipid levels and if a difference was found between AS and control disorders. METHODS: The AS patients were compared to non-inflammatory rheumatic disorders (NIRDs) in 1978-98 and 2000-10 surveys and to rheumatoid arthritis (RA) in the 2000-10 survey...
April 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38634373/analysis-of-risk-factors-associated-with-diffuse-alveolar-haemorrhage-in-patients-with-anca-associated-vasculitis-and-construction-of-a-risk-prediction-model-using-line-graph
#16
JOURNAL ARTICLE
Xuanwei Li, Congyuan Ma, Jiamei Xu, Meng Zhang, Qin Xiang, Yue Li, Wenlai Li, Ping Zhu
OBJECTIVES: This study aims to analyse the risk factors associated with diffuse alveolar haemorrhage (DAH) in patients with ANCA-associated vasculitis (AAV) and construct a risk prediction model using line graph. METHODS: A retrospective study was conducted from January 2012 to May 2023 at the First Clinical College of Three Gorges University, focusing on patients diagnosed with AAV. Clinical and laboratory data were collected from these patients. The potential predictors subsets of high-risk AAV combined with DAH were screened by LASSO regression and 10-fold cross-validation method, and determined by using multivariate Logistic regression analysis, then were used for developing a prediction nomogram for high-risk AAV combined with DAH using the R software...
April 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38634365/endothelial-mesenchymal-transition-promotes-pannus-formation-in-ankylosing-spondylitis-by%C3%A2-activation-of-tgf-%C3%AE-smad-signalling-pathway
#17
JOURNAL ARTICLE
Shaojie Li, Zhiduo Hou, Yao Gong, Jianhua Peng, Hongjin Liang, Danmin Wang, Ling Lin
OBJECTIVES: To explore the role of endothelial-mesenchymal transition (EndMT) mediated by the TGF-β/SMAD signalling pathway in the pathogenesis of ankylosing spondylitis (AS). METHODS: Serum levels of TGF-β1 were measured by enzyme-linked immunosorbent assay (ELISA) in 48 patients with AS and 15 healthy subjects. The expression levels of TGF-β1, SMAD7, CTGF, CD34 and EndMT-related markers (α-SMA, vimentin, FSP-1, VE-cadherin) in the sacroiliac joint (SIJ) of three AS patients were detected by immunohistochemistry, and three non-spondyloarthritis (SpA) autopsy samples were used as controls...
April 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38634363/uncovering-risk-factors-for-adverse-events-and-infections-in-rheumatoid-arthritis-and-rheumatoid-arthritis-with-interstitial-lung-disease-under-treatment-with-biologics-or-targeted-synthetic-dmards-insights-from-the-kobio-registry
#18
JOURNAL ARTICLE
Ji-Won Kim, Kichul Shin, Juyang Jung, Chang-Hee Suh, Jinhyun Kim, Sun-Kyung Lee, Hyoun-Ah Kim
OBJECTIVES: This study aimed to identify the risk factors associated with overall adverse events (AEs) and infections in patients with rheumatoid arthritis (RA) and comorbid interstitial lung disease (ILD), receiving biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs), using data from the Korean College of Rheumatology Biologics registry. METHODS: We analysed data from a cohort of 2,266 adult patients with RA who received b/tsDMARDs, including 169 patients with comorbid ILD...
April 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38607682/the-joint-vasculitis-registry-in-german-speaking-countries-gevas-subgroup-analysis-of-266-aav-patients
#19
JOURNAL ARTICLE
Sabrina Arnold, Pia Wallmeier, Arlette Tais, Gabriele Ihorst, Marco Janoschke, Fabian Schubach, Peer Aries, Raoul Bergner, Jan Phillip Bremer, Norman Görl, Eva Gutdeutsch, Bernhard Hellmich, Jörg Henes, Bimba Franziska Hoyer, Antje Kangowski, Ina Kötter, Martin Krusche, Tim Magnus, Claudia Metzler, Ulf Müller-Ladner, Jana Petersen, Anke Reichelt de Tenorio, Matthias Schaier, Jan Henrik Schirmer, Ulf Schönermarck, Jens Thiel, Leonore Unger, Nils Venhoff, Julia Weinmann-Menke, Christof Iking-Konert, Peter Lamprecht
OBJECTIVES: Prospective long-term observational data on the disease course of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) were missing in Germany to date. Therefore, the Joint Vasculitis Registry in German-speaking countries (GeVas) has been established to follow the course of patients with AAV. The aim of this study is to present baseline data of patients with newly diagnosed and relapsing AAV enrolled in the GeVas registry. METHODS: GeVas is a prospective, web-based, multicentre, clinician-driven registry for the documentation of organ manifestations, damage, long-term outcomes, and therapy regimens in various types of vasculitis...
April 12, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38607693/coronary-artery-calcification-in-takayasu-s-arteritis-clinical-characteristics-and-risk-factors
#20
JOURNAL ARTICLE
Shiyu Yang, Nan Zhang, Wenjing Zhao, Juan Du, Na Gao, Xuemei Shi, Yaxin Zhang, Jiayi Liu, Lili Pan
OBJECTIVES: Coronary artery calcification (CAC) is frequently observed in Takayasu's arteritis (TAK). Our objective is to calculate the prevalence and severity of CAC in TAK, while evaluating the influence of traditional cardiovascular risk factors, glucocorticoid exposure, and disease activity on CAC. METHODS: This retrospective study involved 155 TAK patients. We measured the Agatston score by coronary computed tomography angiography (CCTA) and categorised all patients into groups with or without CAC (41 vs...
April 11, 2024: Clinical and Experimental Rheumatology
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