journal
Journals Clinical and Experimental Rheu...

Clinical and Experimental Rheumatology

https://read.qxmd.com/read/37706291/immunopathological-features-of-myopathy-associated-with-small-to-medium-sized-vessel-vasculitis-and-differences-from-autoimmune-myositis
#1
JOURNAL ARTICLE
Shun Nomura, Yasuhiro Shimojima, Takanori Ichikawa, Daigo Miyazaki, Akinori Uruha, Dai Kishida, Yoshiki Sekijima
OBJECTIVES: Patients with systemic vasculitis may develop myalgia as an initial symptom. However, the immunopathology of vasculitic myopathy remains unclear. We investigated the immunopathological features of skeletal muscle in small-to-medium-sized vessel vasculitis. METHODS: We analysed muscle tissue biopsies from 15 patients with vasculitis, including antineutrophil cytoplasmic antibodyassociated vasculitis and polyarteritis nodosa, and 15 patients with autoimmune myositis (AIM), including polymyositis and immune-mediated necrotising myopathy, as comparison disease controls...
September 14, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706308/haematological-and-other-manifestions-in-the-presence-of-antiphospholipid-antibodies-in-a-multicentric-paediatric-cohort
#2
JOURNAL ARTICLE
Patricia Morán Álvarez, África Andreu-Suárez, Liz Caballero-Mota, Sussana Gassiot-Riu, Rubén Berrueco-Moreno, Joan Calzada-Hernández, Mónica Vázquez-Díaz, Alina Boteanu, Virginia Messia, Luigi Giovannelli, Fabrizio De Benedetti, Jordi Antón-López, Claudia Bracaglia
OBJECTIVES: To identify the variables associated with the development of haematological manifestations in the presence of antiphospholipid antibodies (aPLs) in a paediatric cohort. METHODS: We conducted a multicentric retrospective cohort study of children under the age of 18 years. RESULTS: One hundred and thirty-four children were included; 12.2% had at least one thrombotic event (TE) and 67% at least one non-criterion manifestation. Of them, 90% did not develop any TE...
September 8, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706304/the-multifaceted-role-of-mast-cells-in-the-pathogenesis-of-rheumatoid-arthritis
#3
REVIEW
Francesco Pisani, Cristina Croia, Fiorella Petrelli, Erica Chericoni, Paola Migliorini, Ilaria Puxeddu
Mast cells (MC) are tissue duelling cells playing an active role in both innate and adaptive immune system. They act as first players in different microbial infections and exert a crucial role in allergy, chronic inflammation, fibrosis, and rheumatic diseases (RD), including rheumatoid arthritis (RA). MC are normally present in human synovia and they increase in the joints of RA patients, contributing to inflammatory and remodelling processes. Due to their great plasticity and multifunctionality, MC exert a wide range of roles in different stages of the disease...
September 7, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706334/mucocutaneous-and-gastrointestinal-involvement-of-mis-a-in-a-67-year-old-man-a-case-report
#4
LETTER
Francesca Pistone, Davide Testa, Irene Martelli, Gabriella Sciascia, Grazia Maria Luisa Rizzelli, Alessandra Tripoli, Salvatore De Marco, Paola Migliorini, Antonio Gaetano Tavoni
No abstract text is available yet for this article.
September 6, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706313/the-complement-system-is-linked-to-insulin-resistance-in-patients-with-systemic-lupus-erythematosus
#5
JOURNAL ARTICLE
María García-González, Fuensanta Gómez-Bernal, Juan Carlos Quevedo-Abeledo, Yolanda Fernández-Cladera, Agustín Francisco González-Rivero, Raquel López-Mejías, Federico Díaz-González, Miguel Ángel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Systemic lupus erythematosus (SLE) patients more commonly have insulin resistance (IR) than control subjects. Recent studies have revealed that the complement (C) system is not only a mediator of the immune system but is also related to the pathogenesis of atherosclerosis in the general population. Given that the C alteration is a characteristic of SLE, in the present work we set out to analyse if there is a relationship between the C system and IR in patients with SLE. METHODS: New generation functional assays of the three pathways of the C system were performed in 225 non-diabetic patients with SLE...
September 6, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706288/physical-exercise-is-associated-with-less-fatigue-less-pain-and-better-sleep-in-patients-with-systemic-lupus-erythematosus
#6
JOURNAL ARTICLE
Helena Wohland, Martin Aringer, Nicolai Leuchten
OBJECTIVES: While fatigue is an extremely common complaint of patients with systemic lupus erythematosus (SLE), the information on factors influencing SLE fatigue in the long term is still limited. This study aims to investigate the actual level of physical activity in the daily life of SLE outpatients and its association with fatigue. METHODS: In a cross-sectional survey on 93 SLE outpatients we combined clinical assessment with questionnaires to comprehensively assess SLE fatigue, its impact on function and health-related quality of life (hrQoL), and potential contributing factors, with particular emphasis on physical activity...
September 6, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37706287/distinct-subsets-of-synovial-fibroblasts-control-cartilage-destruction-in-joint-diseases
#7
REVIEW
Hung-Wei Chen, Chi-Hsiang Huang, Chi-Ying F Huang, Chih-Hung Chang, Hsiu-Jung Liao
Inflammation-induced bone destruction is the main cause of progressive joint damage in rheumatoid arthritis (RA) and osteoarthritis (OA). In addition, depending on the tissue microenvironment stimulators, the synovium transforms into a hyperplastic invasive tissue. The synovium includes two specific subsets of fibroblasts surrounding the joints: lining and sublining synovial fibroblasts (SFs). These SFs grow and interact with immune cells invading the bone and cartilage; specifically, SFs, which are the major mesenchymal cells in the joints, develop an aggressive phenotype, thereby producing cytokines and proteases involved in arthritis pathogeneses...
September 6, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650348/associations-between-circulating-interleukin-17-levels-and-behcet-s-disease-and-between-il-17-gene-polymorphisms-and-disease-susceptibility-a-meta-analysis
#8
JOURNAL ARTICLE
Young Ho Lee, Gwan Gyu Song
OBJECTIVES: To systematically investigate the relationship between circulating interleukin-17 (IL-17) levels and Behçet's disease (BD) and the associations between polymorphisms in IL17 genes and BD susceptibility. METHODS: We searched the Medline, Embase, and Cochrane databases for relevant articles. We performed a meta-analysis of serum/plasma IL-17 levels in BD patients and controls and evaluated the associations between IL17A rs4711998, rs8193036, and rs2275913 and IL17F rs763780 and rs2397084 polymorphisms and the risk of BD...
August 31, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650298/comorbidities-in-the-spondyloarthritis-gisea-cohort-an-average-treatment-effect-analysis-on-patients-treated-with-bdmards
#9
JOURNAL ARTICLE
Laura Scagnellato, Antonio Collesei, Andrea Doria, Giacomo Cozzi, Mariagrazia Lorenzin, Fabiola Atzeni, Serena Bugatti, Roberto Caporali, Alberto Cauli, Fabrizio Conti, Addolorata Corrado, Antonio Carletto, Maria Sole Chimenti, Rosario Foti, Bruno Frediani, Roberto Gerli, Roberto Gorla, Marcello Govoni, Elisa Gremese, Serena Guiducci, Annamaria Iagnocco, Florenzo Iannone, Simone Parisi, Maurizio Rossini, Fausto Salaffi, Leonardo Santo, Piercarlo Sarzi Puttini, Marco Sebastiani, Angelo Semerano, Gianfranco Ferraccioli, Giovanni Lapadula, Roberta Ramonda
OBJECTIVES: We aimed to investigate the effectiveness of tumour necrosis factor inhibitors (TNFi), anti-interleukin-17 or interleukin-12/23 monoclonal antibodies (anti-IL) on comorbidities in a cohort of patients with spondyloarthritis (SpA), using an average treatment effect (ATE) analysis. METHODS: SpA patients from the multicentre Italian GISEA Registry were divided into groups according to pharmacological exposure: no treatment (G0), TNFi (G1) and non-responders to TNFi switched to anti-IL (G2)...
August 30, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650346/tocilizumab-as-a-first-line-biologic-agent-in-rheumatoid-arthritis-patients-with-inadequate-response-to-disease-modifying-anti-rheumatic-drugs-real-life-experience-from-the-treasure-registry
#10
JOURNAL ARTICLE
Omer Karadag, Bayram Farisogullari, Burcu Yagiz, Abdulsamet Erden, Zeliha Ademoglu, Gezmis Kimyon, Nazife Sule Bilge, Ozan Cemal Icacan, Levent Kilic, Belkis Nihan Coskun, Emine Duygu Ersozlu, Orhan Kucuksahin, Ridvan Mercan, Suleyman Serdar Koca, Emel Gonullu, Muhammet Cinar, Servet Akar, Hakan Emmungil, Timucin Kasifoglu, Cemal Bes, Ahmet Omma, Yavuz Pehlivan, Sedat Kiraz, Ihsan Ertenli, Ediz Dalkilic, Umut Kalyoncu
OBJECTIVES: To evaluate the retention rate, treatment response and safety of tocilizumab (TCZ) as first-line biologic treatment in rheumatoid arthritis (RA) patients with inadequate response to disease-modifying anti-rheumatic drugs (DMARD-IR). METHODS: The TReasure Registry is a multicentre, web-based registry of RA and spondyloarthritis patients across Turkey. DMARD-IR RA patients who received TCZ as first-line biologic treatment were included in this registry for efficacy and safety...
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650343/primary-pulmonary-diffuse-large-b-cell-lymphoma-with-anti-nxp2-positive-dermatomyositis-a-case-report
#11
LETTER
Fangling Yao, Li Deng, Zheng Liao, Zhenhua Wen
No abstract text is available yet for this article.
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650318/role-of-patrick-faber-test-in-detecting-sacroiliitis-and-diagnosing-spondyloarthritis-in-subjects-with-low-back-pain
#12
JOURNAL ARTICLE
Marco Tasso, Valentina Uguccioni, Nicoletta Bertolini, Alessio Bernasconi, Massimo Mariconda, Raffaele Scarpa, Luisa Costa, Francesco Caso
OBJECTIVES: To evaluate sensitivity, specificity, and predictive value of Patrick-FABER test in assessing magnetic resonance imaging (MRI) sacroiliitis and addressing the diagnosis of spondyloarthritis (SpA) in subjects with low back pain (LBP). METHODS: Subjects with LBP were consecutively enrolled. The assessors were blinded to patients' clinical, laboratory, or imaging data. All subjects underwent sacroiliac joint MRI to detect presence of sacroiliac oedema or structural changes...
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650317/the-prevalence-and-independent-risk-factors-of-elevated-common-carotid-artery-intima-media-thickness-and-carotid-plaque-in-patients-with-gout
#13
JOURNAL ARTICLE
Wantai Dang, Jing Hu, Hui Luo, Danling Luo, Xiaohui Xu, Jian Liu
OBJECTIVES: Gout patients are at high risk of carotid atherosclerosis, which could be convincingly reflected by common carotid artery intima-media thickness (CCAIMT) and carotid plaque. The current study aimed to investigate the prevalence and risk factors of thick CCAIMT and carotid plaque in gout patients. METHODS: Comprehensive demographic characteristics, chronic comorbidities, disease features, and biochemical indexes (42 parameters) were obtained from 237 gout patients...
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650299/exploring-the-xist-axis-as-oxidative-stress-related-signatures-in-systemic-lupus-erythematosus
#14
JOURNAL ARTICLE
Zhihan Chen, Yunfeng Dai, Yongxing Lai, Fei Gao, Yanfang Wu
OBJECTIVES: In the pathogenesis of systemic lupus erythematosus (SLE), oxidative stress (OS) plays an complex role; nevertheless, few investigations have indicated a ceRNA-based mechanism involved. The aim of this study was to explore the ceRNA regulation mechanism of oxidative stress in SLE and provide new therapeutic targets for SLE. METHODS: Three datasets from the Gene Expression Omnibus (GEO) database were used to obtain differentially expressed lncRNAs, miRNAs, and mRNAs (DElncRNAs, DEmiRNAs, and DEmRNAs)...
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650287/primary-aldosteronism-an-unsuspected-culprit-of-hypertension-in-systemic-lupus-erythematosus
#15
REVIEW
Grace S Feng, Joanna R Kent, Peter J Fuller, Alberta Y Hoi, A Richard Kitching, Jun Yang, Fabien B Vincent
Primary aldosteronism (PA) is the most common endocrine cause of secondary hypertension and is associated with a high risk of cardiovascular disease in the general population. Patients suffering from systemic lupus erythematosus (SLE), a multisystem and multifactorial autoimmune disease, experience a high burden of hypertension and cardiovascular disease. Importantly, cardiovascular disease is one of the leading causes of death in SLE. Very limited evidence suggests an increased proportion of autoimmune diseases such as SLE in patients with PA...
August 29, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37650291/the-association-of-serum-uric-acid-with-all-cause-and-cardiovascular-mortality-among-adults-with-rheumatoid-arthritis-a-cohort-study
#16
JOURNAL ARTICLE
Weiming Yang, Qiao Zhang, Jing Liu, Yanmei Xu, Jin Lin, Juanjuan Chen, Xiaozhong Wang
OBJECTIVES: Serum uric acid (SUA) is associated with poor outcomes in patients with numerous types of disease. However, the association between SUA and the outcomes of patients with rheumatoid arthritis (RA) remains to be fully elucidated. Thus, the present study aimed to determine the associations between SUA and all-cause or cardiovascular disease (CVD)-associated mortality in adults with RA. METHODS: The data of patients with RA were collected from the National Health and Nutrition Examination Survey from 2001 to 2018...
August 28, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37584395/paediatric-onset-takayasu-s-arteritis-associates-with-worse-survival-than-adult-onset-takayasu-s-arteritis-a-matched-retrospective-cohort-study
#17
JOURNAL ARTICLE
Durga Prasanna Misra, Darpan R Thakare, Prabhaker Mishra, Upendra Rathore, Kritika Singh, Manas Ranjan Behera, Neeraj Jain, Manish Ora, Dharmendra Singh Bhadauria, Sanjay Gambhir, Sudeep Kumar, Vikas Agarwal
OBJECTIVES: A subset of Takayasu's arteritis (TAK) begins in the paediatric age group (≤18 years). Differences in prognosis between paediatric-onset and adult-onset TAK are unclear. We compared the differences in the presentation and survival between paediatric-onset and adult-onset TAK in our cohort of TAK. METHODS: From a retrospective cohort of TAK, clinical presentation, angiographic features, treatments received, disease activity, and survival were compared between paediatric-onset and adult-onset TAK...
August 16, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37534685/utilisation-of-primary-healthcare-services-by-sj%C3%A3-gren-s-syndrome-patients-in-the-community-of-madrid-and-associated-factors-a-population-based-cross-sectional-study
#18
JOURNAL ARTICLE
Jaime Barrio-Cortes, Tomas Gómez-Gascón, Beatriz Benito-Sánchez, Maria Felicitas Domínguez-Berjón, Maria Dolores Esteban-Vasallo, Juan Pablo Chalco-Orrego, Esther F Vicente-Rabaneda, Chiara Baldini, Chiara Seghieri, Andreas V Goules, Dimitrios I Fotiadis, Athanasios G Tzioufas
OBJECTIVES: To describe the utilisation of primary health care (PHC) services and factors associated with its use by patients diagnosed with Sjögren's syndrome (SS). METHODS: Population-based cross-sectional cohort of SS patients in Madrid, Spain (SIERMA). Sociodemographic, diagnostic, clinical and PHC service utilisation variables were studied by bivariate analyses and regression models. RESULTS: A total of 4,778 SS patients were included, 65...
August 3, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37534684/temporomandibular-joint-involvement-in-psoriatic-arthritis-a-prospective-clinical-and-ultrasonographic-study
#19
JOURNAL ARTICLE
Beatrice Maranini, Stefano Mandrioli, Giovanni Ciancio, Fabio Fabbian, Manlio Galiè, Marcello Govoni
OBJECTIVES: To evaluate the prevalence of temporomandibular disorders (TMD) in a monocentric cohort of patients affected by psoriatic arthritis (PsA), and to investigate the accuracy of temporomandibular joint (TMJ) ultrasound (US) compared with clinical evaluation and clinimetric composite index in assessing TMJ involvement. METHODS: We conducted a prospective cohort study of patients diagnosed with PsA who underwent at least one TMJ US examination and maxillofacial surgeon's evaluation between 2018 and 2021...
August 3, 2023: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/37534674/c-reactive-protein-gene-polymorphisms-influence-susceptibility-and-outcomes-of-biopsy-proven-giant-cell-arteritis-in-italian-patients
#20
JOURNAL ARTICLE
Luigi Boiardi, Enrico Farnetti, Pierluigi Macchioni, Davide Nicoli, Stefania Croci, Francesco Muratore, Chiara Marvisi, Caterina Ricordi, Mariagrazia Catanoso, Elena Galli, Carlo Salvarani
OBJECTIVES: To investigate potential associations between the two functional C-reactive protein (CRP) gene polymorphisms at position 3872C>T (rs1205) and 4741G>C (rs3093068) and susceptibility, clinical expression, laboratory and pathological findings, and outcomes of giant cell arteritis (GCA) in a Nothern Italian population. METHODS: One hundred and seventy Italian patients with biopsy-proven GCA resident in Reggio Emilia area, Italy, and 200 healthy controls from the same geographic area were genotyped for rs1205 and rs3093068 CRP gene polymorphisms by molecular methods...
August 3, 2023: Clinical and Experimental Rheumatology
journal
journal
20072
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.