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Clinical and Experimental Rheumatology

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https://read.qxmd.com/read/30767870/a-probability-score-to-aid-the-diagnosis-of-suspected-giant-cell-arteritis
#1
Faidra Laskou, Fiona Coath, Sarah L Mackie, Siwalik Banerjee, Tin Aung, Bhaskar Dasgupta
OBJECTIVES: We propose a GCA probability score intended to help to risk-stratify patients referred by general practitioners with suspected GCA into those with high probability of GCA versus low probability of GCA. In this pilot study we evaluated the diagnostic accuracy of this proposed scoring system. METHODS: A scoring system was proposed based on clinical experience. Retrospective analysis was conducted from clinical notes of consecutive patients presenting to a Fast Track Pathway clinic between August 2016 and August 2017...
February 15, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767872/anti-myeloperoxidase-antibody-positivity-in-patients-without-primary-systemic-vasculitis
#2
Marilina Antonelou, Lara Perea Ortega, Jennifer Harvey, Alan D Salama
OBJECTIVES: We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital. METHODS: Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK. RESULTS: The incidence of anti-MPO positivity in patients without AAV was 39.5%. Gastrointestinal tract disorders, infections and other connective tissue disorders made up the majority of diagnoses, and there was a higher incidence of other concomitant autoantibodies compared to the group with known AAV...
February 14, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767877/the-mortality-rate-and-causes-of-death-among-juvenile-idiopathic-arthritis-patients-in-finland
#3
Minna Susanna Kyllönen, Hannu Kautiainen, Kari Puolakka, Paula Vähäsalo
OBJECTIVES: To explore mortality rates and causes of death in juvenile idiopathic arthritis (JIA) patients in Finland compared with the general population. METHODS: All incident patients with JIA (age <16 years at the index day) during 2000-2014 were collected from the nationwide register maintained by the Social Insurance Institution of Finland and The National Population Registry identified three age-, sex- and residence-matched controls for each case. They were followed up together until 31st Dec 2015...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767876/metabolites-of-c-reactive-protein-and-vimentin-are-associated-with-disease-activity-of-axial-spondyloarthritis
#4
Anne Sofie Siebuhr, Markéta Hušaková, Sarka Forejtová, Katerina Zegzulková, Michal Tomčik, Monika Urbanová, Kristina Grobelná, Jindra Gatterová, Anne-Christine Bay-Jensen, Karel Pavelka
OBJECTIVES: Non-radiographic (nr-axSpA) and radiographic (AS) forms of axial spondyloarthritis (axSpA) share clinical features, but have different radiographic patterns. Radiographic progression is not associated with the current disease activity biomarkers. We investigated a matrix metalloproteinase mediated metabolite of C-reactive protein (CRPM) and two biomarkers of citrullinated vimentin (VICM and anti-MCV) as novel biomarkers of disease activity. METHODS: AxSpA patients (n=121 nr-axSpA and n=72 AS) were characterised by activity (AS disease activity score with CRP [ASDAS-CRP], Bath AS disease activity index [BASDAI] and functional index [BASFI]), radiographic scores and quality of life questionnaires...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767875/neutrophil-derived-lactoferrin-induces-the-inflammatory-responses-of-rheumatoid-arthritis-synovial-fibroblasts-via-toll-like-receptor-4
#5
Kunihiko Umekita, Shunichi Miyauchi, Hajime Nomura, Kazumi Umeki, Akihiko Okayama
OBJECTIVES: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs). METHODS: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767873/clinical-features-of-systemic-sclerosis-patients-with-anti-rna-polymerase-iii-antibody-in-a-single-centre-in-spain
#6
Eduardo Luis Callejas-Moraga, Alfredo Guillén-Del-Castillo, Ana María Marín-Sánchez, María Roca-Herrera, Eva Balada, Carles Tolosa-Vilella, Vicente Fonollosa-Pla, Carmen Pilar Simeón-Aznar
OBJECTIVES: To evaluate the clinical features and survival of patients with positive anti-RNA polymerase III (anti-RNAP III) in a Spanish single centre. METHODS: We analysed 221 patients with SSc according to LeRoy and Medsger criteria. Twenty-six patients with positivity for anti-RNAP III antibodies were compared with 195 negative patients. Epidemiological, clinical, immunological features and survival were analysed. RESULTS: In patients with anti-RNAP III positivity diffuse cutaneous SSc (dcSSc) subset was the most prevalent (20, 76...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767871/adult-onset-still-s-disease-associated-interstitial-lung-disease-represents-severe-phenotype-of-the-disease-with-higher-rate-of-haemophagocytic-syndrome-and-relapse
#7
Yukiko Takakuwa, Hironari Hanaoka, Tomofumi Kiyokawa, Harunobu Iida, Kana Ishimori, Toshimasa Uekusa, Hidehiro Yamada, Kimito Kawahata
OBJECTIVES: Adult-onset Still's disease (AOSD) is an inflammatory disorder characterised by sustained fevers, arthritis, and skin involvement. Interstitial lung disease (ILD) is a rare manifestation, and its clinical characteristics have yet to be determined. METHODS: We sought to examine the clinical characteristics of AOSD-associated ILD. We retrospectively investigated 78 patients diagnosed as AOSD. ILD was diagnosed based on chest high-resolution computed tomography (HRCT)...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767868/conventional-synthetic-disease-modifying-antirheumatic-drugs-and-bone-mineral-density-in-rheumatoid-arthritis-patients-with-osteoporosis-possible-beneficial-effect-of-leflunomide
#8
Oh Chan Kwon, Ji Seon Oh, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim
OBJECTIVES: To investigate the effect of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on bone mineral density (BMD) in rheumatoid arthritis (RA) patients with osteoporosis. METHODS: Patients with RA who were newly diagnosed with osteoporosis (T-score ≤ -2.5) between 2010 and 2017 were included. All patients received background bisphosphonate for treatment of osteoporosis. BMD was measured at baseline and after one year. To identify csDMARDs or other factors associated with significant increase in BMD (≥3%) at lumbar spine and femoral neck at one year, we performed logistic regression analysis...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767867/il-35-prevent-bone-loss-through-promotion-of-bone-formation-and-angiogenesis-in-rheumatoid-arthritis
#9
Siyan Liu, Yuxuan Li, Liping Xia, Hui Shen, Jing Lu
OBJECTIVES: Angiogenesis in bone and osteogenesis appear to be closely linked, suggesting the existence of molecular crosstalk between pro-angiogenic molecules and osteoblasts. The pro-angiogenic molecules vascular endothelial growth factor (VEGF) with its receptors Flt-1, Flk-1 and fibroblast growth factor (FGF)-2 play a crucial role in born formation, an early and critical event in the pathogenesis of rheumatoid arthritis (RA). Interleukin (IL)-35 is demonstrated to be an anti-inflammatory cytokine in RA...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767866/clinical-features-of-thirty-two-patients-with-anti-melanoma-differentiation-associated-gene-5-antibodies
#10
Wenhan Huang, Feifeng Ren, Qian Wang, Lei Luo, Jun Zhou, Dongmei Huang, Zhuma Pan, Lin Tang
OBJECTIVES: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies. METHODS: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767865/rate-of-serious-infections-in-spondyloarthropathy-patients-treated-with-anti-tumour-necrosis-factor-drugs-a-survey-from-the-italian-registry-gisea
#11
Fabiola Atzeni, Piercarlo Sarzi-Puttini, Marco Sebastiani, Valentina Panetta, Fausto Salaffi, Florenzo Iannone, Antonio Carletto, Rosario Foti, Elisa Gremese, Marcello Govoni, Antonio Marchesoni, Ennio Favalli, Roberto Gorla, Roberta Ramonda, Gianfranco Ferraccioli, Giovanni Lapadula
OBJECTIVES: To determine the incidence of serious infections (SIs) among the spondyloarthropathy (SpA) patients from the "Gruppo Italiano per lo Studio delle Early Arthritis" (GISEA) registry and treated with tumour necrosis factor (TNF) inhibitors (TNFIs), and to identify the factors associated with the development of the infections. METHODS: This observational study on 3321 GISEA-registered SpA patients collected real-world demographic and clinical data relating to their biological drug treatments...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767864/the-effect-of-jak1-jak2-inhibition-in-rheumatoid-arthritis-efficacy-and-safety-of-baricitinib
#12
REVIEW
Ernest H S Choy, Corinne Miceli-Richard, Miguel A González-Gay, Luigi Sinigaglia, Douglas E Schlichting, Gabriella Meszaros, Inmaculada de la Torre, Hendrik Schulze-Koops
Numerous cytokines have been implicated in the pathogenesis of inflammatory diseases, and their dysregulation is a main feature of rheumatoid arthritis (RA). Cytokines stimulate signal transduction through several intracellular pathways, including Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathways, leading to changes in cell activation, proliferation and survival. Consequently, agents that selectively target elements of the JAK/STAT pathways have received significant attention in recent years as potential new treatments for the disease...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767863/what-are-the-main-barriers-to-achieve-minimal-disease-activity-in-psoriatic-arthritis-in-real-life
#13
Sibel Bakirci, Dilek Solmaz, Noura Al Osaimi, Ediz Dalkilic, Meryem Can, Abdulsamet Erden, Cem Ozisler, Muhammet Cinar, Levent Kilic, Adem Küçük, Ahmet Omma, Fatih Yildiz, Atalay Doğru, Abdurrahman Tufan, Serpil Ergulu Esmen, Servet Akar, Umut Kalyoncu, Sibel Zehra Aydin
OBJECTIVES: Minimal disease activity (MDA) is an important target in patients with psoriatic arthritis (PsA), however it is also criticised for having a low threshold for patient reported outcomes (PRO).The aim of the study was to assess the prevalence of MDA and its components in patients with PsA and to evaluate disease characteristics and patterns in patients with or without MDA (MDA+ or MDA-). METHODS: PsArt-ID (Psoriatic Arthritis-International Database) is a prospective, multicentre web-based registry...
February 11, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767874/predictive-value-of-ex-vivo-drug-inhibited-cytokine-production-for-clinical-response-to-biologic-dmard-therapy-in-rheumatoid-arthritis
#14
Lieke Tweehuysen, Alfons A den Broeder, Kiki Schraa, Mihai G Netea, Frank H J van den Hoogen, Leo A B Joosten
OBJECTIVES: To investigate ex-vivo drug-inhibited cytokine production before the start of a biological DMARD (bDMARD) as predictor of treatment response in rheumatoid arthritis (RA). METHODS: In a prospective RA cohort study [BIO-TOP], blood samples were obtained from patients before the start of a bDMARD (abatacept, adalimumab, etanercept, rituximab or tocilizumab). Peripheral blood mononuclear cells were pre-incubated for 1 hour with the therapeutic in-vivo concentration of the bDMARD and stimulated for 24 hours with heat-killed Candida albicans or Pam3Cys...
February 7, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30767869/efficacy-of-bisphosphonates-in-patients-with-synovitis-acne-pustulosis-hyperostosis-and-osteitis-syndrome-a-prospective-open-study
#15
Chen Li, Yanxue Zhao, Yuzhi Zuo, Yangzhong Zhou, Fa Zhang, Sen Liu, Qiankun Zhu, Jia Chen, Weihong Zhang, Wenrui Xu, Zhaoqi Gu, Li Li, Feng Li, Weilan Tao, Yihan Cao, Xiaochuan Sun, Hongli Jing, Hui Chen, Siya Zhang, Zhenhua Dong, Jinhe Liu, Xiaohu Shi, Weixin Hao, Guixing Qiu, Wen Zhang, Nan Wu, Zhihong Wu
OBJECTIVES: To evaluate the clinical efficacy of bisphosphonates treatment for spinal bone marrow oedema (BME) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. METHODS: SAPHO syndrome patients presenting to Peking Union Medical College Hospital from 2015 to 2016 were recruited. Patients were administered pamidronate disodium 1 mg/kg/d intravenously, for 3 days, at baseline and 3 months later. The symptoms were evaluated using the Visual Analog Score (VAS) for pain, and other clinical measures including, spinal BME scores, β-crosslaps, osteocalcin, and inflammatory factors, were collected...
February 7, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30719969/s100a11-calgizzarin-is-released-by-circulating-mononuclear-cells-and-its-elevated-plasma-levels-distinguish-systemic-lupus-erythematosus-patients-from-healthy-individuals
#16
LETTER
Lucie Andres Cerezo, Barbora Šumová, Hana Hulejová, Hana Štorkánová, Lenka Szczuková, Michal Tomčík, Radim Bečvář, Karel Pavelka, Jiří Vencovský, Jakub Závada, Ladislav Šenolt
No abstract text is available yet for this article.
February 4, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30719968/efficacy-of-anti-tumour-necrosis-factor-%C3%AE-monoclonal-antibodies-in-patients-with-non-infectious-anterior-uveitis
#17
Claudia Fabiani, Antonio Vitale, Donato Rigante, Giacomo Emmi, Giuseppe Lopalco, Jurgen Sota, Lorenzo Vannozzi, Silvana Guerriero, Alice Bitossi, Ida Orlando, Rossella Franceschini, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
OBJECTIVES: To assess the efficacy of monoclonal anti-tumour necrosis factor (TNF)-α agents in patients with anterior uveitis (AU) in terms of decrease of recurrences, variation of visual acuity and steroid sparing effect and to identify any demographic, clinical or therapeutic variables associated with a sustained response to monoclonal TNF-α inhibitors. METHODS: Data from patients suffering from AU treated with adalimumab, infliximab, golimumab or certolizumab pegol were retrospectively collected and statistically analysed...
January 18, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30719967/current-and-early-life-weight-and-associations-with-mortality-in-rheumatoid-arthritis
#18
Joshua F Baker, Andrew Stokes, Ted R Mikuls, Michael George, Bryant R England, Harlan Sayles, Kaleb Michaud
OBJECTIVES: Obesity is paradoxically associated with a lower risk of mortality in chronic illnesses including rheumatoid arthritis (RA). Weight loss in patients with poor health, however, may in part explain this observation. This study evaluated the impact of weight early in life and weight loss on mortality in patients with RA. METHODS: Patients with RA (age >40 years) were active participants in a prospective clinical registry with up to 17 years of follow-up...
January 18, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30719970/increased-expression-levels-of-fc%C3%AE-riib-on-na%C3%A3-ve-and-double-negative-memory-b-cells-in-patients-with-systemic-sclerosis
#19
Natsuki Yagi-Numata, Takashi Matsushita, Kazuhiko Takehara, Yasuhito Hamaguchi
OBJECTIVES: In systemic sclerosis (SSc), B cell hyperactivation and abnormality are considered to play an important role in the disease pathophysiology. We aimed to clarify if the abnormal activation of B cells involves inhibitory FcγRIIB on B cells in SSc patients. METHODS: Blood samples were collected from 76 SSc patients (38 limited cutaneous SSc and 38 diffuse cutaneous SSc) and 59 healthy controls. We evaluated the expression levels of FcγRIIB on different B cell subsets...
January 17, 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30652675/serum-cytokine-and-chemokine-levels-in-patients-with-eosinophilic-granulomatosis-with-polyangiitis-hypereosinophilic-syndrome-or-eosinophilic-asthma
#20
Christian Pagnoux, Parameswaran Nair, Yao Xi, Nader A Khalidi, Simon Carette, David Cuthbertson, Peter C Grayson, Curry L Koening, Carol A Langford, Carol A McAlear, Larry W Moreland, Paul A Monach, Phil Seo, Ulrich Specks, Antoine G Sreih, Steve R Ytterberg, Pascal N Tyrrell, Peter A Merkel
OBJECTIVES: The pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) remains poorly understood, and may overlap with eosinophilic asthma and primary hypereosinophilic syndrome (HES). The aim of this study was to analyse a panel of serum cytokines and chemokines as markers of disease activity in patients with these conditions. METHODS: The levels of 54 cytokines and chemokines were measured in the sera of 40 patients with active EGPA, 10 of these patients during inactive disease, 6 patients with HES, 8 with asthma, and 10 healthy controls...
January 14, 2019: Clinical and Experimental Rheumatology
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