journal
Journals Clinical and Experimental Rheu...

Clinical and Experimental Rheumatology

https://read.qxmd.com/read/38489320/role-of-tlr7-in-the-pathogenesis-of-primary-sj%C3%A3-gren-s-syndrome
#21
REVIEW
Yue Song, Wei Zhou
Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterised by immune-driven damage to the exocrine glands, leading to diminished salivary and tear production. While the pathogenesis of pSS remains incompletely understood, its clinical presentations vary widely, and no specific treatments are currently available. Toll-like receptor 7 (TLR7) belongs to the Toll-like receptor family and is crucial for the innate immune response, notably in recognising pathogenic patterns. TLR7 is predominantly found in the endoplasmic reticulum (ER) and endosomes, where it identifies single-stranded RNA (ssRNA)...
March 12, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38451142/neuromodulation-with-aerobic-exercise-reduces-fatigue-in-systemic-lupus-erythematosus-a-randomised-sham-controlled-double-blind-study
#22
JOURNAL ARTICLE
Vanessa P de Andrade, Alexandre M Dos Santos, Luciana P C Seguro, Emily F N Yuki, Michelle R U Lopes, Marcus V Grecco, Eduardo F Borba, Julia M A Greve, Samuel K Shinjo
OBJECTIVES: Transcranial direct current stimulation (tDCS) combined with aerobic exercise (tDCS-AE) effectively reduces fatigue in patients with fibromyalgia. However, no study has assessed this method in systemic lupus erythematosus (SLE) patients with significant fatigue. Therefore, we evaluated the safety and efficacy of tDCS-AE for significant fatigue symptoms in adult female SLE patients. METHODS: This randomised, sham-controlled, double-blind study included 25 patients with SLE in remission or low disease activity (SLEDAI-2K £4) and with significant fatigue [≥36 points on the Fatigue Severity Scale (FSS) or ≥38 points on the Modified Fatigue Scale (MFIS)]...
March 7, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38451159/beauty-and-health-an-intriguing-liaison
#23
JOURNAL ARTICLE
Enzo Grossi
The exposure to different form of beauty coming from visual art, music, nature, architecture, improves mental health and exerts neurotrophic effects on different parts of the brain. This in turn improves physical health, prolongs life expectancy, and reduces the risk of serious degenerative diseases such as Alzheimer's and cancer. These beneficial actions would not be understandable and plausible if one did not accept the mind-body unity. The 'hegemonic' role of the brain in health and illness can be discerned, for example, in the effect of emotions on vital physiological parameters, in the relationships between stress and many medical-clinical pathologies, in the control exercised by the brain over the immune system reflecting also in the inhibition of tumour progression...
March 6, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436382/collaborative-research-in-myositis-related-disorders-mihra-a-global-shared-community-model
#24
JOURNAL ARTICLE
Lesley Ann Saketkoo, Julie J Paik, Helene Alexanderson, Mazen M Dimachkie, Floranne C Ernste, Elie Naddaf, Barbara Shafranski, Latika Gupta, Christopher A Mecoli, Didem Saygin, Jemima Albayda, Pari Basharat, Jessica A Day, Antonia Valenzuela, Rachel Bromley, Ingrid de Groot, Suzanne E Edison, Aviya Lanis, Christian Lood, Malin Regardt, Belina Y Yi, Alejandro C Benitez, Hector Chinoy, Lisa Christopher-Stine, David A Isenberg, Bianca Lang, Chester V Oddis, Annet van Royen, Jiri Vencovsky, Victoria P Werth, Pedro M Machado
Myositis International Health and Research Collaborative Alliance (MIHRA) is a newly formed purpose-built non-profit charitable research organization dedicated to accelerating international clinical trial readiness, global professional and lay education, career development and rare disease advocacy in IIM-related disorders. In its long form, the name expresses the community's scope of engagement and intent. In its abbreviation, MIHRA, conveys linguistic roots across many languages, that reflects the IIM community's spirit with meanings such as kindness, community, goodness, and peace...
March 4, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436358/two-year-treatment-persistence-with-subcutaneous-abatacept-in-rheumatoid-arthritis-results-from-the-french-cohort-of-the-ascore-study
#25
JOURNAL ARTICLE
René-Marc Flipo, Arnaud Constantin, Philippe Goupille, Mélanie Chartier, Anaël Ohayon, Xavier Mariette
OBJECTIVES: While multiple studies have investigated treatment persistence rates with intravenous abatacept, limited information is available about real-world treatment continuation with the subcutaneous form. The international ASCORE study described the characteristics and treatment persistence of real-world patients with rheumatoid arthritis (RA) receiving subcutaneous abatacept. This article presents the findings of the French cohort. METHODS: This was an observational study in French RA patients who initiated subcutaneous abatacept between August 2014 and January 2017...
March 3, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436300/il-17-producing-cells-in-ankylosing-spondylitis-patients-show-gender-based-differences-in-gene-expression
#26
JOURNAL ARTICLE
Chan Mi Lee, Ernest Ricky Chan, Darerian Schueller, Maya Breitman, Maricela Haghiac, Marina Magrey
OBJECTIVES: Gender has been shown to impact disease expression in ankylosing spondylitis (AS) and Th17 cells play a key role in AS pathogenesis. To better understand what Th17-associated immune pathways are different between men and women, we compared the transcriptome of IL-17-enriched peripheral blood mononuclear cells (PBMCs) in male and female AS patients, with a particular focus on inflammatory cytokine genes. METHODS: PBMCs were collected from 10 female and 11 male AS patients at the Clinical Research Unit of MetroHealth Medical Center...
March 3, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436296/increased-expression-of-omentin-1-is-associated-with-synovitis-and-bone-destruction-in-rheumatoid-arthritis
#27
JOURNAL ARTICLE
Yali Wu, Xin Li, Jing Ke, Baoyu Zhang, Dong Zhao
OBJECTIVES: The aberrant expression of omentin-1 had been reported in type 2 diabetes and cardiovascular disease. Here, we investigated the expression and role of omentin-1 in rheumatoid arthritis (RA). METHODS: The expression of omentin-1 in RA and in the normal population was detected by ELISA and immunohistochemistry, and collagen-induced arthritis (CIA) mice were used to detect the role of omentin-1 in RA. RESULTS: We found that the expression of omentin-1 was elevated in serum of RA patients compared with healthy controls (p=0...
March 3, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436356/phenotypic-spectrum-of-inclusion-body-myositis
#28
REVIEW
Bhaskar Roy, Mazen M Dimachkie, Elie Naddaf
Inclusion body myositis (IBM) is a progressive, debilitating muscle disease commonly encountered in patients over the age of 50. IBM typically presents with asymmetric, painless, progressive weakness and atrophy of deep finger flexors and/or quadriceps muscle. Many patients with IBM develop dysphagia. However, atypical presentations of IBM with isolated dysphagia, asymptomatic hyper-CKemia, foot drop, proximal weakness, axial weakness, and facial diplegia have been reported. Other acquired and some inherited disorders may present similar to IBM, and this list gets more expansive when considering atypical presentations...
February 28, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436279/performance-of-the-2017-eular-acr-classification-criteria-for-adult-and-juvenile-idiopathic-inflammatory-myopathies-and-their-major-subgroups-a-scoping-review
#29
REVIEW
Didem Saygin, Stefanie Glaubitz, Rachel Zeng, Matteo Bottai, Marianne de Visser, Mazen M Dimachkie, David Fiorentino, Ingrid Gerhardson, Masataka Kuwana, Frederick W Miller, Merrilee Needham, Lisa G Rider, Yasser Salem, Silke Schlüter, Samuel K Shinjo, Guochun Wang, Victoria P Werth, Rohit Aggarwal, Ingrid E Lundberg
The 2017 EULAR/ACR classification criteria for adult/juvenile idiopathic inflammatory myopathies (IIM) were established using a data-driven approach by an international group of myositis experts to allow classification of IIM and its major subtypes. Since their publication, the performance of the criteria has been tested in multiple cohorts worldwide and significant limitations have been identified. Moreover, the understanding and classification of IIM have evolved since 2017. This scoping review was undertaken as part of a large international project to revise the EULAR/ACR criteria and aims to i) summarise the evidence from the current literature on the performance characteristics of the 2017 EULAR/ACR classification criteria in various cohorts and IIM subtypes, and ii) delineate the factors that need to be considered in the revision of the classification criteria...
February 28, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436267/treatment-with-lysophosphatidic-acid-improves-glomerulonephritis-through-the-suppression-of-macrophage-activation-in-a-murine-model-of-systemic-lupus-erythematosus
#30
JOURNAL ARTICLE
Wataru Nagata, Eiji Takayama, Keiichi Nakagawa, Akiho Koizumi, Yukiko Ohsawa, Hiroyasu Goto, Aoi Yamashiro, Yuki Ishinoda, Keiko Tanoue, Hiroo Kumagai, Naoki Oshima, Toshiaki Ishizuka
OBJECTIVES: Several therapeutic agents have been developed and used for the clinical treatment of systemic lupus erythematosus (SLE). In cases where SLE is accompanied by severe organ failures, such as neuropsychiatric lupus erythematosus (NPSLE) and acute onset of lupus nephritis, the use of potent immunosuppressive drugs, such as cyclophosphamide, is necessary. However, potent immunosuppressive drugs are known to increase infection risks. Thus, the development of therapeutic agents with novel mechanisms is urgently required...
February 28, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436327/exercise-recommendations-for-patients-with-myositis-a-narrative-review-of-safety-and-efficacy
#31
REVIEW
Nicole Varone, Jose Hinojosa, Dhruv Nandakumar, Naysa Modi, Abhiram R Bhashyam, Salman F Bhai
Idiopathic inflammatory myopathies (IIM) are marked by progressive muscle weakness and lasting disability. Therapies targeting patient well-being include the use of prescription drugs as well as exercise. Maintaining or increasing muscular strength and endurance as well as cardiorespiratory fitness (CRF) improves quality of life (QoL) as well as functional status in IIM patients. This narrative review highlights exercise interventions in patients of different IIM subtypes with the intent to provide a summary table with exercise recommendations that will safely and effectively improve QoL in myositis patients...
February 20, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38436270/prediction-of-the-activity-of-early-ankylosing-spondylitis-using-radiomics-texture-analysis-on-stir
#32
JOURNAL ARTICLE
Zhaojuan Shi, Zhe Yang, Datian Su, Juan Cheng, Zhaoxia Shi, Mei Wang, Hui Zheng, Jiankui Han, Changqin Li, Jian Qin
OBJECTIVES: The study aimed to explore the value of texture analysis of radiomics based on the short tau inversion recovery (STIR) sequence to evaluate the activity of bone marrow oedema of sacroiliac joints in early AS. METHODS: 43 patients with early AS whose data were randomly divided into the training cohort (n=116) and verification cohort (n=56) according to the ratio of 7:3. The optimal feature subsets were obtained by Mann-Whitney U-test, the minimum-Redundancy Maximum-Relevancy (mRMR), and then least absolute shrinkage and selection operator (LASSO) using these texture feature parameters, which were used to construct the final prediction model and obtained the Radscore...
February 20, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372729/intravenous-immunoglobulin-in-the-treatment-of-sporadic-inclusion-body-myositis-time-for-new-evidence
#33
LETTER
Lorenzo Fontanelli, Gabriele Vadi, Erika Schirinzi, Giulia Di Rauso, Gabriele Bellini, Giulia Ricci, Gabriele Siciliano
No abstract text is available yet for this article.
February 19, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372715/the-need-for-international-multicentre-collaborative-studies-to-better-characterise-the-clinical-profile-of-anti-th-to-positive-patients-reply-to-the-comment-by-sakaida-et-al
#34
LETTER
Liala Moschetti, Paolo Airò, Maria Grazia Lazzaroni
No abstract text is available yet for this article.
February 19, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372730/imaging-swallowing-function-and-the-mechanisms-driving-dysphagia-in-inclusion-body-myositis
#35
REVIEW
Sharfaraz Salam, Jodi Allen, Mazen M Dimachkie, Michael G Hanna, Pedro M Machado
Sporadic inclusion body myositis (IBM) is a progressive condition which commonly affects patients aged above 40. IBM does not respond to immunosuppression and no proven treatments are available. Up to 80% of patients develop some degree of swallowing impairment during the disease course. Dysphagia is a source of marked morbidity in IBM and predisposes patients to life-threatening complications such as aspiration pneumonia. The pathophysiology behind dysphagia in IBM is not fully understood. Evidence from imaging demonstrates that impaired swallowing is predominantly underpinned by oropharyngeal deficits...
February 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372725/blunted-sudomotor-reactivity-in-fibromyalgia-is-associated-with-levels-of-depression
#36
JOURNAL ARTICLE
Ailyn Garcia-Hernandez, Pablo de la Coba, Gustavo A Reyes Del Paso
OBJECTIVES: Assessment of sudomotor function by distal electrochemical skin conductance (ESC) can provide an index of peripheral neuropathy. This study explored ESC in fibromyalgia (FM) patients, controlling for tricyclic antidepressant use and body mass index, and its association with the clinical severity of the disease. METHODS: ESC, clinical symptoms and an index of central pain sensitisation derived from pressure algometry were explored in thirty-three fibromyalgia patients and 33 healthy women...
February 16, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372711/issues-in-the-classification-of-myositis-patients-an-ongoing-process
#37
EDITORIAL
Giovanni Zanframundo, Albert Selva-O'Callaghan, Miguel Ángel González-Gay, Carlomaurizio Montecucco, Lorenzo Cavagna
No abstract text is available yet for this article.
February 13, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372709/a-case-of-anti-th-to-antibody-positive-interstitial-lung-disease-and-pulmonary-arterial-hypertension-that-does-not-meet-the-classification-criteria-of-systemic-sclerosis-comment-on-the-article-by-moschetti-et-al
#38
LETTER
Eri Sakaida, Yuta Yamashita, Yoshinao Muro, Mirai Sawa, Teruyuki Mitsuma, Masashi Akiyama
No abstract text is available yet for this article.
February 13, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372731/rheumatoid-arthritis-synovial-fluid-shows-enrichment-of-t-cells-producing-gmcsf-which-are-polyfunctional-for-tnf%C3%AE-and-ifn%C3%AE
#39
JOURNAL ARTICLE
Aastha Khullar, Varun Dhir, Biman Saikia, Ashok Kumar Yadav, Bidyalaxmi Leishangthem, Chandra Bhushan Prasad, Sankar Jayaprakash, Siddharth Jain, G S R S N K Naidu, Shefali K Sharma, Aman Sharma, Sanjay Jain
OBJECTIVES: GMCSF+T-cells may be involved in pathogenesis of rheumatoid arthritis (RA), and polyfunctionality may be a marker of pathogenicity. Although, higher frequencies of CD4+GMCSF+ T-cells have been reported, there are no data on CD8+GMCSF+ T-cells or polyfunctionality.Our objective was to enumerate frequencies of CD8+GMCSF+ T cells in RA blood and synovial fluid (SF), and assess their polyfunctionality, memory phenotype and cytotoxic ability. METHODS: This study included RA patients (blood samples,in some with paired synovial fluid (SF)), healthy controls (HC) (blood) and SpA patients (SF)...
February 12, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38372728/association-of-mica-and-nkg2d-genetic-variants-with-disease-susceptibility-and-outcome-of-anti-tnf-therapy-in-patients-with-axial-spondyloarthritis
#40
JOURNAL ARTICLE
Joanna Wielińska, Bartosz Bugaj, Jerzy Świerkot, Katarzyna Kolossa, Milena Iwaszko, Sławomir Jeka, Katarzyna Bogunia-Kubik
OBJECTIVES: The disruption of the NKG2D-MICA axis can induce an enhanced immune response and promote autoimmune processes during axial spondyloarthritis (axSpA) pathogenesis. We aimed to investigate potential relationships between selected single nucleotide polymorphisms within the MICA and NKG2D genes and disease susceptibility and clinical parameters in axSpA patients treated with TNF inhibitors. METHODS: Genotyping of MICA rs1051792 and NKG2D rs1154831, rs1049174, and rs2255336 was performed in 163 axSpA patients and 234 healthy controls using a real-time PCR method...
February 12, 2024: Clinical and Experimental Rheumatology
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