journal
https://read.qxmd.com/read/38857507/weight-excess-and-obesity-are-associated-with-binge-eating-behaviours-in-people-with-hiv
#21
JOURNAL ARTICLE
Maria Mazzitelli, Claudia Cozzolino, Gianluca Gasparini, Eleonora Chiaro, Camilla Brazzale, Flavia Mancino, Sara Mingardo, Lolita Sasset, Davide Leoni, Vincenzo Baldo, Angela Favaro, Annamaria Cattelan
OBJECTIVE: Binge eating (BE) is a mental health disorder related to weight gain (WG), whose prevalence/correlation with weight excess in people with HIV (PWH) have been scarcely investigated.Design: A cross-sectional study of PWH who underwent the validated Binge eating scale (BES) questionnaire. METHODS: We included adult PWH during routine visits from October 2022 to February 2023. The BES questionnaire was administered with the support of a psychiatrist (score <17 BE very unlikely, BE≥17 possible/very likely)...
June 10, 2024: AIDS
https://read.qxmd.com/read/38831733/choice-of-antiretroviral-therapy-has-low-impact-on-weight-gain
#22
JOURNAL ARTICLE
Henning Drechsler, Colby Ayers, Ikwo Oboho, Ngozi Enwerem, John Hanna, Christopher Clark, Ellen Kitchell, Mamta Jain, Amneris Luque, Roger Bedimo
OBJECTIVE: Antiretroviral therapy (ART) containing integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF) has been associated with greater weight gain. Yet few studies have delineated between exposure to "anchor" drugs (protease inhibitors [PI], non-nucleoside reverse transcriptase inhibitors [NNRTI] or INSTIs) and exposure to nucleoside reverse transcriptase inhibitors (NRTIs). DESIGN: In this cohort of antiretroviral (ARV) naïve patients who initiated ART from 2008-2022, we analyzed body mass index (BMI) gain for 8 contemporary "anchor" drugs and 3 contemporary NRTIs during the first 3 years of ART...
June 3, 2024: AIDS
https://read.qxmd.com/read/38831732/a-predictive-model-for-hiv-related-lymphoma-a-case-series-and-literature-review-in-japan
#23
JOURNAL ARTICLE
Shuhei Kurosawa, Yukihiro Yoshimura, Yusuke Takada, Takako Yokota, Masaki Hibi, Ayumi Hirahara, Tsutomu Yoshida, So Okubo, Moe Masuda, Yuna So, Nobuyuki Miyata, Hitomi Nakayama, Aki Sakurai, Kosuke Sato, Chisako Ito, Yoshinobu Aisa, Tomonori Nakazato
OBJECTIVES: To address the paucity of human immunodeficiency virus (HIV)-related lymphoma (HRL)-specific prognostic scores for the Japanese population by analyzing domestic cases of HRL and constructing a predictive model. DESIGN: A single-center retrospective study coupled with a review of case reports of HRL. METHODS: We reviewed all patients with HRL treated at our hospital between 2007 and 2023 and conducted a comprehensive search for case reports of HRL from Japan using public databases...
June 3, 2024: AIDS
https://read.qxmd.com/read/38819841/impact-of-enhanced-adherence-counselling-on-viral-re-suppression-among-adolescents-and-young-persons-with-persistent-viremia
#24
JOURNAL ARTICLE
Anne Wasilwa, Emmanuel Amadi, Habib O Ramadhani, Taylor Lascko, Angela Ndaga, Violet Makokha, Kepha Abuya, Daniel Oneya, Lennah Nyabiage, Caroline Ng'eno
OBJECTIVE: Kenya ART guidelines recommend three sessions of enhanced adherence counselling (EAC) following detectable viral load (VL). The objective of this study was to assess completion of EAC sessions and factors associated with viral re-suppression amongst adolescents and young persons (AYPs) with persistent viremia in Western Kenya. METHODS: A retrospective analysis of routinely collected data abstracted from VL registers was done. AYP with persistent viremia (consecutive VL ≥ 1,000 copies/ml) between October 2017 to September 2019 were followed for 12 months; those with >1 follow-up VL results were analyzed...
May 31, 2024: AIDS
https://read.qxmd.com/read/38819840/interferon-signaling-pathways-are-upregulated-in-people-with-hiv-with-abnormal-pulmonary-diffusing-capacity-dlco
#25
JOURNAL ARTICLE
Michelle Zhang, Guorui Dai, Dana L Smith, Emanuela Zacco, Michiko Shimoda, Nitasha Kumar, Valerie Girling, Kendall Gardner, Peter W Hunt, Laurence Huang, Jue Lin
People living with HIV (PLWH) are at greater risk of developing lung diseases even when they are antiretroviral therapy (ART)-adherent and virally suppressed. The most common pulmonary function abnormality in PLWH is that of impaired diffusing capacity of the lungs for carbon monoxide (DLCO), which is an independent risk factor for increased mortality in PLWH. Earlier work has identified several plasma biomarkers of inflammation and immune activation to be associated with decreased DLCO. However, the underpinning molecular mechanisms of HIV-associated impaired DLCO are largely unknown...
May 31, 2024: AIDS
https://read.qxmd.com/read/38819839/mavmet-trial-maraviroc-and-or-metformin-for-metabolic-dysfunction-associated-fatty-liver-disease-mafld-in-adults-with-suppressed-hiv
#26
JOURNAL ARTICLE
Leanne Mccabe, James E Burns, Arash Latifoltojar, Frank A Post, Julie Fox, Erica Pool, Anele Waters, Beatriz Santana, Lucy Garvey, Margaret Johnson, Ian Mcguinness, Manil Chouhan, Jonathan Edwards, Anna L Goodman, Graham Cooke, Claire Murphy, Yolanda Collaco-Moraes, Helen Webb, Adam Gregory, Fatima Mohamed, Mary Rauchenberger, Stephen D Ryder, Chris Sandford, Jason V Baker, Brian Angus, Christoph Boesecke, Chloe Orkin, Shonit Punwani, Andrew Clark, Richard Gilson, David Dunn, Sarah L Pett
OBJECTIVE: Metabolic dysfunction-associated fatty liver disease (MAFLD) is over-represented in people living with HIV (PLWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and fatty acid metabolism. DESIGN: Open-label, 48-week randomised trial with a 2x2 factorial design. SETTING: Multicentre HIV clinics. PARTICIPANTS: Nondiabetic, virologically-suppressed PLWH, aged ≥35 years, with confirmed/suspected MAFLD (≥1 biochemical/anthropometric/radiological/histological features)...
May 31, 2024: AIDS
https://read.qxmd.com/read/38819837/the-impact-of-financial-incentives-on-mental-health-among-adults-in-hiv-care-in-lake-zone-tanzania-a-two-arm-randomized-controlled-trial
#27
JOURNAL ARTICLE
Pooja Chitle, Lila A Sheira, Emmanuel Katabaro, Solis Winters, Prosper F Njau, Amon Sabasaba, Sandra I Mccoy
OBJECTIVE: Depression and anxiety are prevalent among people living with HIV (PLHIV), hindering retention in care. Though economic interventions can improve care engagement and mental health in the general population, this remains understudied among PLHIV. This study assessed whether financial incentives improve mental health among adult antiretroviral therapy (ART) initiates in Lake Zone, Tanzania. DESIGN: Two-arm randomized controlled trial. METHODS: From 2021-2023, 32 clinics were randomized to offer patients monthly financial incentives (22,500 TSH/$10 USD) for ≤6 months (conditional on visit attendance) or standard-of-care (SoC) services...
May 31, 2024: AIDS
https://read.qxmd.com/read/38819818/characterization-of-the-gut-butyrate-producing-bacteria-and-lipid-metabolism-in-african-green-monkey-as-a-natural-host-of-siv-infection
#28
JOURNAL ARTICLE
Jingjing Zhao, Xiaojun Zhou, Yefeng Qiu, Rui Jia
OBJECTIVE: Natural hosts of simian immunodeficiency virus (SIV), such as the African green monkey (AGM), possess the ability to avoid acquired immune deficiency syndrome (AIDS) despite lifelong infection. The underlying mechanisms are not completely understood. This study aimed to characterize the gut microbiome and metabolite profiles of different nonhuman primates (NHPs) to provide potential insight into AIDS resistance. DESIGN AND METHODS: Fresh feces from Cynomolgus macaques (CMs), and Rhesus macaques (RMs), SIV- AGMs (AGM_N), and SIV+ AGMs (AGM_P) were collected and used for metagenomic sequencing and metabonomic analysis...
May 31, 2024: AIDS
https://read.qxmd.com/read/38814695/a-randomised-trial-of-fresh-start-text-messaging-to-improve-return-to-care-in-people-living-with-hiv-who-missed-appointments-in-south-africa
#29
JOURNAL ARTICLE
Christine Njuguna, Lawrence Long, Preethi Mistri, Candice Chetty-Makkan, Brendan Maughan-Brown, Alison Buttenheim, Laura Schmucker, Sophie Pascoe, Harsha Thirumurthy, Cara O'Connor, Chipo Mutyambizi, Barry Mutasa, Kate Rees
OBJECTIVE: Treatment interruptions are a barrier to successful antiretroviral therapy (ART). "Fresh start messages", which leverage significant days on the calendar (e.g., new year, public holiday) in order to prompt action, have the potential to encourage people living with HIV to return to care. We evaluated a "fresh start" intervention (text messages) to increase return to care in PLHIV who had missed their last appointment. DESIGN: A three arm 1:1:1 individual randomised controlled trial...
May 29, 2024: AIDS
https://read.qxmd.com/read/38814693/prevalence-of-detectable-hiv-dna-and-rna-in-cerebrospinal-fluid-of-youth-with-perinatal-hiv-and-impaired-cognition-on-antiretroviral-therapy
#30
JOURNAL ARTICLE
Thor A Wagner, Camlin Tierney, Sharon Huang, Sharon Nichols, Kathleen M Malee, Nicole A Montañez, Anne Coletti, Hans M L Spiegel, Chelsea Krotje, Frederic Bone, Megan Wilkins, Lisa Abuogi, Murli Purswani, Allison Bearden, Andrew Wiznia, Allison Agwu, Ellen G Chadwick, Douglas Richman, Monica Gandhi, Patrick Mehta, Bernard Macatangay, Stephen A Spector, Serena Spudich, Deborah Persaud, Ann Chahroudi
OBJECTIVE: Central nervous system (CNS) HIV infection can impact cognition and may be an obstacle to cure in adolescents and young adults with perinatal HIV (AYAPHIV). IMPAACT2015 enrolled AYAPHIV on suppressive antiretroviral therapy (ART) with cognitive impairment to detect and quantify HIV in blood and cerebrospinal fluid (CSF). DESIGN: IMPAACT2015 was a U.S.-based multi-site, exploratory, observational study. METHODS: Cognitive impairment was defined as NIH Toolbox Fluid Cognition Composite score (FCCS) > 1 standard deviation below age-adjusted normative group mean...
May 29, 2024: AIDS
https://read.qxmd.com/read/38814683/self-injurious-unnatural-death-among-veterans-with-hiv-a-nested-case-control-study
#31
JOURNAL ARTICLE
Alexandria C Smith, Joseph L Goulet, David Vlahov, Amy C Justice, Julie A Womack
OBJECTIVE: People living with HIV (PWH) are at increased risk of suicide and death from unintentional causes compared with people living without HIV. Broadening the categorization of death from suicide to self-injurious unnatural death (SIUD) may better identify a more complete set of modifiable risk factors that could be targeted for prevention efforts among PWH. DESIGN: We conducted a nested case-control study using data from the Veterans Aging Cohort Study (VACS), a longitudinal, observational cohort of Veterans from 2006-2015...
May 29, 2024: AIDS
https://read.qxmd.com/read/38788210/immunogenicity-of-a-bivalent-ba-1-covid-19-booster-vaccine-in-people-with-hiv-in-the-netherlands
#32
JOURNAL ARTICLE
Marlou J Jongkees, Ngoc H Tan, Daryl Geers, Rory D de Vries, Corine H Geurtsvankessel, Kathryn S Hensley, Roos S G Sablerolles, Susanne Bogers, Lennert Gommers, Blerdi Blakaj, Pedro Miranda Afonso, Bettina E Hansen, Bart J A Rijnders, Kees Brinkman, P Hugo M van der Kuy, Anna H E Roukens, Casper Rokx
OBJECTIVE: We evaluated the immunogenicity of a bivalent BA.1 COVID-19 booster vaccine in people with HIV (PWH). DESIGN: Prospective observational cohort study. METHODS: PWH aged ≥45 years received Wuhan-BA.1 mRNA-1273.214 and those < 45 years Wuhan-BA.1 BNT162b2. Participants were propensity score-matched 1:2 to people without HIV (non-PWH) by age, primary vaccine platform (mRNA-based or vector-based), number of prior COVID-19 boosters and SARS-CoV-2 infections, and spike (S1)-specific antibodies on the day of booster administration...
May 24, 2024: AIDS
https://read.qxmd.com/read/38788206/improving-hiv-pre-exposure-prophylaxis-uptake-with-artificial-intelligence-and-automation-a-systematic-review
#33
JOURNAL ARTICLE
Emiko Kamitani, Yuko Mizuno, George M Khalil, Alexander Viguerie, Julia B DeLuca, Ninad Mishra
OBJECTIVES: To identify studies promoting the use of artificial intelligence (AI) or automation with HIV pre-exposure prophylaxis (PrEP) care and explore ways for AI to be used in PrEP interventions. DESIGN: Systematic review. METHODS: We searched in the US Centers for Disease Control and Prevention Research Synthesis database through November 2023 PROSPERO (CRD42023458870). We included studies published in English that reported using AI or automation in PrEP interventions...
May 24, 2024: AIDS
https://read.qxmd.com/read/38788204/associations-between-epicardial-visceral-and-subcutaneous-adipose-tissue-with-diastolic-function-in-men-with-and-without-hiv
#34
JOURNAL ARTICLE
Rachel L Goldberg, Tess E Peterson, Sabina A Haberlen, Mallory D Witt, Frank J Palella, Jared W Magnani, Todd T Brown, Jordan E Lake, Joao A C Lima, Matt J Budoff, Chiadi E Ndumele, Katherine C Wu, Wendy S Post
BACKGROUND: People with HIV (PWH) are at greater risk for diastolic dysfunction (DD) compared to persons without HIV (PWOH). An increase in visceral adipose tissue (AT) is common among PWH and greater visceral AT is associated with DD among PWOH. We investigated associations of visceral AT, subcutaneous AT and other fat depots with subclinical DD among men with and without HIV (MWH/MWOH). DESIGN: Cross-sectional analysis of MWH and MWOH in the Multicenter AIDS Cohort Study (MACS)...
May 24, 2024: AIDS
https://read.qxmd.com/read/38770825/the-ebi2-receptor-is-coexpressed-with-ccr5-in-cd4-t-cells-and-boosts-hiv-1-r5-replication
#35
JOURNAL ARTICLE
Adeline Guigues, Sandrine Gimenez, Clément Mettling, Damien Maurel, Etienne Doumazane, Laurent Prézeau, Vincent François, Pierre Corbeau
OBJECTIVE: CCR5, a G protein-coupled receptor (GPCR), is used by most HIV strains as a coreceptor. In this study, we looked for other GPCRs able to modify HIV-1 infection. DESIGN: We analyzed the effects of one GPCR coexpressed with CCR5, EBI2, on HIV-1 replicative cycle. METHODS: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. We studied GPCR dimerization by FRET technology. Cell lines expressing EBI2 were established by transduction with HIV vectors...
May 21, 2024: AIDS
https://read.qxmd.com/read/38768443/bridging-dolutegravir-clinical-viral-response-across-doses-and-formulations-using-model-based-exposure-response-analysis-in-pediatrics
#36
JOURNAL ARTICLE
Hardik Chandasana, Siobhán Hayes, Ann M Buchanan, Cynthia Brothers, Andrew Wiznia, Mattie Bartlett, Stephanie Popson, Ellen Townley, Kathy George, Cindy Vavro, Theodore Ruel, Edward P Acosta, Rajendra Singh
OBJECTIVE: Dolutegravir (DTG) is a once-daily HIV-1 integrase inhibitor approved for the treatment of HIV-1 infection in adults and children from 4 weeks of age. The posology of DTG in children has been driven by exposure-matching relative to the adult dose for efficacy and safety. However, higher variability in pediatric exposures raises concern that efficacy may not be reliably extrapolated from adult trials. Therefore, we evaluated the relationship between DTG exposure and virologic response in children...
May 20, 2024: AIDS
https://read.qxmd.com/read/38752558/an-agricultural-livelihood-intervention-is-associated-with-reduced-hiv-stigma-among-people-living-with-hiv
#37
JOURNAL ARTICLE
Sheri D Weiser, Lila A Sheira, Elly Weke, Jennifer M Zakaras, Pauline Wekesa, Edward A Frongillo, Rachel L Burger, Adrienne Rain Mocello, Harsha Thirumurthy, Shari L Dworkin, Alexander C Tsai, James G Kahn, Lisa Butler, Elizabeth A Bukusi, Craig R Cohen
OBJECTIVE: HIV stigma undermines antiretroviral treatment (ART) adherence and viral suppression. Livelihood interventions may target drivers of negative attitudes towards people living with HIV (PLHIV) by improving their health and strengthening their economic contributions. We examined the effects of a multisectoral agricultural livelihood intervention on HIV stigma among PLHIV in western Kenya. DESIGN: Sixteen health facilities were randomly allocated (1:1) to intervention or control arms in Shamba Maisha, a cluster randomized controlled trial that aimed to improve HIV-related health through behavioral, mental health, and nutritional pathways...
May 16, 2024: AIDS
https://read.qxmd.com/read/38752557/oral-prep-uptake-adherence-and-persistence-during-periconception-periods-among-women-in-south-africa-an-intervention-study
#38
JOURNAL ARTICLE
Lynn T Matthews, Manjeetha Jaggernath, Yolandie Kriel, Patricia M Smith, Jessica E Haberer, Jared M Baeten, Craig W Hendrix, Norma C Ware, Pravi Moodley, Melendhran Pillay, Kara Bennett, John Bassler, Christina Psaros, Kathleen E Hurwitz, David R Bangsberg, Jennifer A Smit
OBJECTIVE: We developed the Healthy Families-PrEP intervention to support HIV-prevention during periconception and pregnancy. We evaluated preexposure prophylaxis (PrEP) use with three objective measures. DESIGN: This single-arm intervention study enrolled women in KwaZulu-Natal, South Africa, who were HIV-uninfected, not pregnant, in a relationship with a partner with HIV or unknown-serostatus, and with pregnancy plans. PrEP was offered as part of a comprehensive HIV prevention intervention...
May 15, 2024: AIDS
https://read.qxmd.com/read/38742882/the-relationship-between-anti-lgbtq-legislation-and-hiv-prevention-among-sexual-and-gender-minoritized-youth
#39
JOURNAL ARTICLE
Nicole K Kelly, Shabbar I Ranapurwala, Brian W Pence, Lisa B Hightow-Weidman, Jaime Slaughter-Acey, Audrey L French, Sybil Hosek, Audrey E Pettifor
OBJECTIVE: Estimate the longitudinal associations of state-level anti-LGBTQ+ policies and county-level politics with individual HIV prevention outcomes among sexual and gender minoritized (SGM) youth. DESIGN: Keeping it LITE-1 prospectively enrolled 3,330 SGM youth and young adults (ages 13-34) at increased risk of HIV throughout the United States from 2017-2022. METHODS: Semiannual surveys collected self-reported HIV prevention measures (current PrEP use, weekly PrEP adherence, HIV/STI testing in the past 6 months)...
May 14, 2024: AIDS
https://read.qxmd.com/read/38742881/impact-of-hiv-pre-exposure-prophylaxis-prescriptions-on-hiv-diagnoses-in-new-york-city
#40
JOURNAL ARTICLE
Qiang Xia, Zoe R Edelstein, Benjamin Katz, Daniel Bertolino, Amanda Berry, Benjamin W Tsoi, Lucia V Torian
BACKGROUND: HIV preexposure prophylaxis (PrEP) has proven to be efficacious and effective in preventing HIV infections, but few studies have reported its impact in the real world. METHODS: We conducted an ecological analysis and compared the trends in HIV PrEP prescriptions with the trends in age-adjusted HIV diagnosis rates in New York City (NYC). Joinpoint regression analyses were used to identify any temporal trends in HIV diagnosis rates in NYC. RESULTS: The number of people filling at least one PrEP prescription in NYC increased from 2551 in 2014 to 35 742 in 2022...
May 14, 2024: AIDS
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