Gayatri Nikhila Kadiyala, Sushama Telwatte, Adam Wedrychowski, Julie Janssens, Sun Jin Kim, Peggy Kim, Steven Deeks, Joseph K Wong, Steven A Yukl
OBJECTIVES: Some drugs that augment cell-intrinsic defenses or modulate cell death/survival pathways have been reported to selectively kill cells infected with HIV or SIV, but comparative studies are lacking. We hypothesized that these drugs may differ in their ability to kill cells infected with intact and defective proviruses. DESIGN: To investigate this hypothesis, drugs were tested ex vivo on Peripheral Blood Mononuclear Cells (PBMC) from nine ART-suppressed individuals...
April 16, 2024: AIDS
Iulia Filip
No abstract text is available yet for this article.
April 16, 2024: AIDS
Preeti Moar, Kyaw Linn, Thomas A Premeaux, Scott Bowler, Urvinder Kaur Sardarni, Bindu Parachalil Gopalan, Ei E Shwe, Thidar San, Haymar Han, Danielle Clements, Chaw S Hlaing, Ei H Kyu, Cho Thair, Yi Y Mar, Nway Nway, Julie Mannarino, Jacob Bolzenius, Soe Mar, Aye Mya M Aye, Ravi Tandon, Robert Paul, Lishomwa C Ndhlovu
OBJECTIVE: Adolescents with perinatally-acquired HIV (AWH) are at an increased risk of poor cognitive development but the underlying mechanisms remain unclear. Circulating galectin-9 (Gal-9) has been associated with increased inflammation and multi-morbidity in adults with HIV despite anti-retroviral therapy (ART), however, relationship between Gal-9 in AWH and cognition remain unexplored. DESIGN: A cross-sectional study of two independent age-matched cohorts from India [AWH on ART (n = 15), ART-naïve (n = 15), and adolescents without HIV (AWOH; n = 10)] and Myanmar [AWH on ART (n = 54) and AWOH (n = 22)] were studied...
April 12, 2024: AIDS
John M Flores, Tyrone Moline, Seann D Regan, Yen-Tyng Chen, Cho-Hee Shrader, John A Schneider, Dustin T Duncan, Byoungjun Kim
OBJECTIVE: The objective of this study is to use GPS technology to determine if violent and property crime exposure to participants activity spaces affect outcomes of the HIV prevention and care continuum (PCC) among Young Black sexually minoritized men (YBSMM) and Transgender women (TW), a subgroup at high vulnerability for new HIV diagnoses. Exposure to violent and property crime adversely affects a variety of acute and chronic medical conditions; however the relationship between exposure to violent and property crime and HIV risk (e...
April 10, 2024: AIDS
Yoonyoung Jang, Taehwa Kim, Yunsu Choi, Kyoung Hwan Ahn, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Shin-Woo Kim, Jun Yong Choi, Hyo Youl Kim, Joon Young Song, Hee Jung Choi, Sang Il Kim, Jang Wook Sohn, BumSik Chin, Bo-Youl Choi, Boyoung Park
INTRODUCTION: This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea. METHODS: Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1,814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1:4 ratio) were included in this nested case-control study...
April 10, 2024: AIDS
Piter Oosterhof, Matthijs Van Luin, Kees Brinkman, David M Burger
OBJECTIVES: Antiretroviral therapy (ART) accounts for a considerable proportion of HIV care expenses. In June 2021, a Dutch healthcare insurer implemented a mandatory policy to de-simplify branded RPV/TDF/FTC (Eviplera®) into a two-tablet regimen containing rilpivirine (Edurant®) plus generic TDF/FTC as part of cost-saving measures. The objectives of this study were to evaluate (1) the acceptance of this policy, (2) the trends in antiretroviral therapy dispensation, and (3) cost developments...
April 10, 2024: AIDS
Giovanni Guaraldi, Jovana Milic, Stefano Renzetti, Federico Motta, Felice Cinque, Jenny Bischoff, Andrea Desilani, Jacopo Conti, Filippo Medioli, Martina Del Monte, Dana Kablawi, Wesal Elgretli, Stefano Calza, Cristina Mussini, Juergen K Rockstroh, Giada Sebastiani
OBJECTIVE: People with HIV (PWH) have high risk of liver fibrosis. We investigated the effect of weight gain and metabolic dysfunction-associated steatotic liver disease (MASLD) on liver fibrosis dynamics. DESIGN: Multicenter cohort study. METHODS: Fibrosis progression was defined as development of significant fibrosis (liver stiffness measurement [LSM]≥8 kPa), or transition to cirrhosis (LSM≥13 kPa), for those with significant fibrosis at baseline...
April 10, 2024: AIDS
Chantal Saberian, Kathryn Lurain, Lindsay K Hill, Vickie Marshall, Elena M Cornejo Castro, Nazzarena Labo, Wendell Miley, Kyle Moore, Romin Roshan, Margie Ruggerio, Kerry Ryan, Anaida Widell, Irene Ekwede, Ralph Mangusan, Adam Rupert, Amisha Barochia, Denise Whitby, Robert Yarchoan, Ramya Ramaswami
OBJECTIVE: Kaposi sarcoma is a vascular tumor that affects the pulmonary system. However, the diagnosis of airway lesions suggestive of pulmonary Kaposi sarcoma (pKS) is reliant on bronchoscopic visualization. We evaluated the role of Kaposi sarcoma herpesvirus (KSHV) viral load in bronchoalveolar lavage (BAL) as a diagnostic biomarker in patients with bronchoscopic evidence of pKS and evaluated inflammatory cytokine profiles in BAL and blood samples. DESIGN: In this retrospective study, we evaluated KSHV viral load and cytokine profiles within BAL and blood samples in patients who underwent bronchoscopy for suspected pKS between 2016 and 2021...
April 2, 2024: AIDS
Sahera Dirajlal-Fargo, Wendy Yu, Denise L Jacobson, Ayesha Mirza, Mitchell E Geffner, Jennifer Jao, Grace A Mccomsey
The relationships between alterations in the intestinal barrier, and bacterial translocation with the development of metabolic complications in youth with perinatally-acquired HIV (YPHIV) have not been investigated. The PHACS Adolescent Master Protocol enrolled YPHIV across 15 U.S. sites, including Puerto Rico, from 2007-2009. For this analysis, we included YPHIV with HIV viral load ≤1000 c/mL, with at least one measurement of homeostatic assessment of insulin resistance (HOMA-IR) or non-high density lipoprotein (non-HDLc) between baseline and year 3 and plasma levels of intestinal fatty-acid binding protein (I-FABP), lipopolysaccharide binding protein (LBP), and zonulin levels at baseline...
March 28, 2024: AIDS
Edith V Sullivan, Natalie M Zahr, Qingyu Zhao, Kilian M Pohl, Stephanie A Sassoon, Adolf Pfefferbaum
OBJECTIVE: With aging, people living with HIV (PLWH) have diminishing postural stability that increases liability for falls. Factors and neuromechanisms contributing to instability are incompletely known. Brain white matter abnormalities seen as hyperintense (WMH) signals have been considered to underlie instability in normal aging and PLWH. We questioned whether sway-WMH relations endured after accounting for potentially relevant demographic, physiological, and HIV-related variables...
March 27, 2024: AIDS
Melissa C Schnure, Parastu Kasaie, David W Dowdy, Becky L Genberg, Emily A Kendall, Anthony T Fojo
OBJECTIVES: Expansion of ART and increases to life expectancy have led to aging among people living with HIV (PWH). DESIGN: Kenyan decisionmakers need accurate forecasts of the age distribution of PWH to inform future policies. METHODS: We developed a model of HIV in Kenya, calibrated to historical estimates of HIV epidemiology. We forecasted changes in population size and age distribution of new HIV infections and PWH under the status quo and under scale-up of HIV services...
March 27, 2024: AIDS
Sara Gianella, Christy Anderson, Antoine Chaillon, Alan Wells, Magali Porrachia, Gemma Caballero, Milenka Vargas, Joseph Lonergan, Brendon Woodworth, Noah Gaitan, Stephen A Rawlings, Leticia Muttera, Liliana Harkness, Susan J Little, Susanne May, Davey Smith
OBJECTIVE: :We sought to determine if standard influenza and pneumococcal vaccines can be used to stimulate HIV reservoirs during antiretroviral therapy (ART). DESIGN: :Prospective, randomized, double-blinded, placebo-controlled, crossover trial of two clinically recommended vaccines (influenza and pneumococcal). METHODS: :Persons with HIV on ART (N = 54) were enrolled in the clinical trial. Blood was collected at baseline and days 2,4,7,14 and 30 postimmunizations...
March 25, 2024: AIDS
Eline S Wijstma, Vita W Jongen, Anders Boyd, Mark van den Elshout, Henry J C de Vries, Udi Davidovich, Peter L Anderson, Maria Prins, Elske Hoornenborg, Maarten F Schim van der Loeff
OBJECTIVE: We assessed the association and concordance between self-reported oral preexposure prophylaxis (PrEP) intake in a diary app and intraerythrocytic drug metabolite concentrations. DESIGN: AMPrEP was a prospective demonstration study providing daily and event-driven PrEP to MSM in Amsterdam, the Netherlands (2015-2020). METHODS: Participants could record their PrEP intake in a diary app. Dried blood spots (DBS) were taken at 6, 12, 24, and 48 months and analysed for tenofovir diphosphate (TFV-DP) and emtricitabine triphosphate (FTC-TP) concentrations...
March 21, 2024: AIDS
Christopher G Kemp, Brian W Pence, Jennifer Velloza, Tessa Concepcion, Modhurima Moitra, Michael Iroezindu, Emmanuel Bahemana, Hannah Kibuuka, Michael Semwogerere, John Owuoth, Jonah Maswai, Rither Langat, Allahna L Esber, Nicole F Dear, Ajay Parikh, Trevor A Crowell, Julie A Ake, Christina S Polyak, Pamela Y Collins
OBJECTIVE: :We estimated the effects of cumulative exposure to depressive symptoms on risk of all-cause mortality among people living with HIV in four African countries. DESIGN: :Analysis of prospective cohort data. METHODS: :The African Cohort Study (AFRICOS) is a prospective cohort of people receiving care at twelve clinics in Kenya, Nigeria, Tanzania, and Uganda. Every six months from January 2013 to May 2020, participants underwent laboratory monitoring, structured surveys, and assessment of depressive symptom severity using the Center for Epidemiologic Studies Depression Scale (CES-D)...
March 20, 2024: AIDS
Richard Migisha, Geoffrey Chen, Winnie R Muyindike, Taing Nandi Aung, Victoria Nanfuka, Nimusiima Komukama, Nomathemba Chandiwana, Gugulethu Shazi, Dessie Tien, Mahomed-Yunus S Moosa, Ravindra K Gupta, Deenan Pillay, Vincent C Marconi, Bethany Hedt-Gauthier, Willem D F Venter, Mark J Siedner, Suzanne M McCluskey, Jennifer Manne-Goehler
BACKGROUND: People with HIV (PWH) on integrase inhibitor-based regimens may be at risk of excess weight gain, but it is unclear if this risk is consistent across settings. We assessed weight change over 48 weeks among PWH who were transitioned to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD). DESIGN: We conducted a prospective cohort study at public-sector HIV clinics in Uganda and South Africa. METHODS: Eligible participants were adults who were transitioned to TLD...
March 20, 2024: AIDS
Preetam A Cholli, Kate M Buchacz, Norma S Harris, Stacy M Crim, Xin Yuan, Yunfeng Tie, Linda J Koenig, Linda Beer
OBJECTIVES: To evaluate associations between self-rated health (SRH) and care outcomes among United States adults with diagnosed HIV infection. DESIGN: We analyzed interview and medical record data collected during June 2020-May 2021 from the Medical Monitoring Project, a complex, nationally representative sample of 3,692 people with HIV (PWH). Respondents reported SRH on a 5-point Likert type scale (poor to excellent), which we dichotomized into "good or better" and "poor or fair"...
March 20, 2024: AIDS
Nel Jason L Haw, Catherine R Lesko, Derek K Ng, Jennifer Lam, Raynell Lang, Mari M Kitahata, Heidi Crane, Joseph Eron, M John Gill, Michael A Horberg, Maile Karris, Mona Loutfy, Kathleen A Mcginnis, Richard D Moore, Keri Althoff, Allison Agwu
OBJECTIVE: To describe the incidence of diabetes mellitus type 2 (T2DM), hypercholesterolemia, hypertriglyceridemia, hypertension, and chronic kidney disease (CKD) from 2000 to 2019 among North American adults with perinatally-acquired HIV (PHIV) aged 18 to 30. DESIGN: Description of outcomes based on electronic health records for a cohort of 375 young adults with PHIV enrolled in routine HIV care at clinics contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)...
March 19, 2024: AIDS
Fei-Hong Hu, Xiao-Lei Tang, Meng-Wei Ge, Yi-Jie Jia, Wan-Qing Zhang, Wen Tang, Lu-Ting Shen, Wei Du, Xiao-Peng Xia, Hong-Lin Chen
OBJECTIVE: Children and adolescents with HIV infection are well-known to face a heightened risk of tuberculosis. However, the exact mortality rates and temporal trends of those with HIV-TB co-infection remain unclear. We aimed to identify the overall mortality and temporal trends within this population. METHODS: PubMed, Web of Science, and Embase were employed to search for publications reporting on the mortality rates of children and adolescents with HIV-TB co-infection from inception to March 2, 2024...
March 18, 2024: AIDS
Danielle K Colbrunn, Courtney Jacks, Scott R Curry, Mulugeta Gebregziabher, Eric G Meissner
OBJECTIVE: The aim of this study was to examine outcomes of follow-up for persons with discordant fourth-generation HIV screening test results. DESIGN: A retrospective chart review. METHODS: We analyzed the electronic health record at the Medical University of South Carolina for a 10-year period spanning 2012-2022 to identify instances of discordant HIV screening test results, wherein initial antigen/antibody screening was positive, but reflex confirmatory testing for HIV-1 and HIV-2 antibodies was negative...
March 14, 2024: AIDS
Trevor A Crowell, Justin Ritz, Lu Zheng, Asma Naqvi, Joshua C Cyktor, Joseph Puleo, Brian Clagett, Javier R Lama, Cecilia Kanyama, Susan J Little, Susan E Cohn, Sharon A Riddler, Ann C Collier, Sonya L Heath, Pornphen Tantivitayakul, Beatriz Grinsztejn, Roberto C Arduino, James F Rooney, Gert U van Zyl, Robert W Coombs, Lawrence Fox, Jintanat Ananworanich, Joseph J Eron, Scott F Sieg, John W Mellors, Eric S Daar
OBJECTIVE: To assess how antiretroviral therapy (ART) initiation during acute or early HIV infection (AEHI) affects the viral reservoir and host immune responses. DESIGN: Single-arm trial of ART initiation during AEHI at 30 sites in the Americas, Africa, and Asia. METHODS: HIV DNA was measured at week 48 of ART in 5 million CD4+ T cells by sensitive qPCR assays targeting HIV gag and pol. Peripheral blood mononuclear cells were stimulated with potential HIV T cell epitope peptide pools consisting of env, gag, nef, and pol peptides and stained for expression of CD3, CD4, CD8, and intracellular cytokines/chemokines...
March 14, 2024: AIDS
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