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Most Read Papers - Gastroenterology

Most Read Papers - Gastroenterology

https://read.qxmd.com/read/38670139/colorectal-polypectomy-and-endoscopic-mucosal-resection-european-society-of-gastrointestinal-endoscopy-esge-guideline-update-2024
#1
JOURNAL ARTICLE
Monika Ferlitsch, Cesare Hassan, Raf Bisschops, Pradeep Bhandari, Mário Dinis-Ribeiro, Mauro Risio, Gregorios A Paspatis, Alan Moss, Diogo Libânio, Vincente Lorenzo-Zúñiga, Andrei M Voiosu, Matthew D Rutter, Maria Pellisé, Leon M G Moons, Andreas Probst, Halim Awadie, Arnaldo Amato, Yoji Takeuchi, Alessandro Repici, Gabriel Rahmi, Hugo U Koecklin, Eduardo Albéniz, Lisa-Maria Rockenbauer, Elisabeth Waldmann, Helmut Messmann, Konstantinos Triantafyllou, Rodrigo Jover, Ian M Gralnek, Evelien Dekker, Michael J Bourke
1:  ESGE recommends cold snare polypectomy (CSP), to include a clear margin of normal tissue (1-2 mm) surrounding the polyp, for the removal of diminutive polyps (≤ 5 mm).Strong recommendation, high quality of evidence. 2:  ESGE recommends against the use of cold biopsy forceps excision because of its high rate of incomplete resection.Strong recommendation, moderate quality of evidence. 3:  ESGE recommends CSP, to include a clear margin of normal tissue (1-2 mm) surrounding the polyp, for the removal of small polyps (6-9 mm)...
April 26, 2024: Endoscopy
https://read.qxmd.com/read/38642564/pathophysiology-and-therapeutic-options-for-cirrhotic-portal-hypertension
#2
REVIEW
Sergi Guixé-Muntet, Sergio Quesada-Vázquez, Jordi Gracia-Sancho
Portal hypertension represents the primary non-neoplastic complication of liver cirrhosis and has life-threatening consequences, such as oesophageal variceal bleeding, ascites, and hepatic encephalopathy. Portal hypertension occurs due to increased resistance of the cirrhotic liver vasculature to portal blood flow and is further aggravated by the hyperdynamic circulatory syndrome. Existing knowledge indicates that the profibrogenic phenotype acquired by sinusoidal cells is the initial factor leading to increased hepatic vascular tone and fibrosis, which cause increased vascular resistance and portal hypertension...
April 17, 2024: Lancet. Gastroenterology & Hepatology
https://read.qxmd.com/read/38668926/efficacy-and-safety-of-liraglutide-in-patients-with-patients-with-an-ileal-pouch-anal-anastomosis-and-chronic-high-bowel-frequency-a-placebo-controlled-crossover-proof-of-concept-study
#3
JOURNAL ARTICLE
Hans Herfarth, Millie D Long, Jonathan J Hansen, Chelsea Anderson, Emily Ba English, John B Buse, Edward L Barnes
INTRODUCTION: After colectomy with ileo-anal pouch anastomosis (IPAA), many patients develop high bowel frequency (BF) refractory to antimotility agents despite normal IPAA morphology. Low circulating levels of glucagon-like protein-1 (GLP-1), a modulator of gastroduodenal motility, have been reported after colectomy. METHODS: Double-blind crossover study of 8 IPAA patients with refractory high BF treated with daily administration of the GLP-1 receptor agonist (GLP-1-RA) liraglutide or placebo...
April 12, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38647094/small-bowel-bleeding
#4
JOURNAL ARTICLE
Zongli Han, Yanli Du
New England Journal of Medicine, Volume 390, Issue 16, April 25, 2024.
April 20, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38645779/esophageal-motor-abnormalities-in-gastroesophageal-reflux-disorders
#5
REVIEW
Wei-Yi Lei, Chih-Hsun Yi, Tso-Tsai Liu, Jui-Sheng Hung, Ming-Wun Wong, Chien-Lin Chen
Gastroesophageal reflux disease (GERD), a prevalent condition with multifactorial pathogenesis, involves esophageal motor dysmotility as a key contributing factor to its development. When suspected GERD patients have an inadequate response to proton-pump inhibitor (PPI) therapy and normal upper endoscopy results, high-resolution manometry (HRM) is utilized to rule out alternative diagnosis such as achalasia spectrum disorders, rumination, or supragastric belching. At present, HRM continues to provide supportive evidence for diagnosing GERD and determining the appropriate treatment...
2024: Tzu chi medical journal
https://read.qxmd.com/read/38517351/a-british-society-for-haematology-guideline-on-the-assessment-and-management-of-bleeding-risk-prior-to-invasive-procedures
#6
JOURNAL ARTICLE
Will Lester, Clare Bent, Raza Alikhan, Laura Roberts, Tim Gordon-Walker, Sarah Trenfield, Richard White, Colm Forde, Deepa J Arachchillage
No abstract text is available yet for this article.
March 22, 2024: British Journal of Haematology
https://read.qxmd.com/read/38619115/focal-distal-esophageal-dilation-blown-out-myotomy-after-achalasia-treatment-prevalence-and-associated-symptoms
#7
JOURNAL ARTICLE
Thijs Kuipers, Fraukje A Ponds, Paul Fockens, Barbara A J Bastiaansen, John E Pandolfino, Albert J Bredenoord
METHODS: A dataset of the locally treated patients in a randomized controlled trial comparing POEM with pneumatic dilation (PD) was analyzed. A BOM is defined as a >50% increase in esophageal diameter at its widest point in the distal esophagus between the lower esophageal sphincter and 5 cm above. RESULTS: 74 patients were treated in our center, 5-year follow-up data was available in 55 patients (32 (58%) patients randomized to POEM, 23 (42%) PD). In the group initially treated with POEM the incidence of BOM increased from 11...
April 15, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38614138/artificial-intelligence-and-medical-liability-in-gastrointestinal-endoscopy
#8
JOURNAL ARTICLE
Sami Elamin, Mindy Duffourc, Tyler M Berzin, Mark E Geissler, Sara Gerke
No abstract text is available yet for this article.
March 30, 2024: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/38372687/magnesium-disorders-core-curriculum-2024
#9
REVIEW
Emmanuel A Adomako, Alan S L Yu
Magnesium is ubiquitous in nature. It sits at the origin of the food chain, occupying the center of chlorophyl in plants. In humans, magnesium is critical to diverse molecular and catalytic processes, including energy transfer and maintenance of the genome. Despite its abundance, hypomagnesemia is common and often goes undiagnosed. This is in spite of epidemiologic data linking low magnesium with chronic diseases including diabetes mellitus. Clinically significant hypermagnesemia is encountered less frequently, but the presentation may be dramatic...
February 16, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38619136/effects-of-clip-anchoring-on-preventing-migration-of-fully-covered-self-expandable-metal-stent-in-patients-undergoing-ercp-a-multicenter-randomized-controlled-study
#10
JOURNAL ARTICLE
Xu Wang, Xin Shi, Hui Luo, Gui Ren, Xiangping Wang, Jianghai Zhao, Hui Li, Bo Ning, Hang Yi, Li Zhong, Rongchun Zhang, Zhi Ni, Shuhui Liang, Mingxing Xia, Bing Hu, Yanglin Pan, Daiming Fan
OBJECTIVES: Fully covered self-expandable metal stents (FCSEMS) are commonly placed in patients with biliary stricture during endoscopic retrograde cholangiopancreatography (ERCP). However, up to 40% of migration has been reported, resulting in treatment failure or the requirement for further intervention. Here we aimed to investigate the effects of metal clip anchoring on preventing the migration of FCSEMS. METHODS: Consecutive patients requiring placement of FCSEMS were included in this multicenter randomized trial...
April 15, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38607627/semaglutide-vs-endoscopic-sleeve-gastroplasty-for-weight-loss
#11
JOURNAL ARTICLE
Muhammad Haseeb, Jagpreet Chhatwal, Jade Xiao, Pichamol Jirapinyo, Christopher C Thompson
IMPORTANCE: Obesity is a disease with a large socioeconomic burden. Endoscopic sleeve gastroplasty (ESG) is a minimally invasive endoscopic bariatric procedure with wide global adoption. More recently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (eg, semaglutide), have attracted increased attention due to their efficacy. However, their cost-effectiveness over an extended period compared with ESG is a critical gap that needs to be better explored for informed health care decision-making...
April 1, 2024: JAMA Network Open
https://read.qxmd.com/read/38569813/eosinophilic-esophagitis-clinical-pearls-for-primary-care-providers-and-gastroenterologists
#12
REVIEW
Rohit Goyal, Amrit K Kamboj, Diana L Snyder
Eosinophilic esophagitis (EoE) is a chronic and progressive immune-mediated esophageal disorder. Given its increasing incidence, it is now a leading cause of dysphagia and food impaction in the United States. Eosinophilic esophagitis is most common in adult White men and has a high concurrence rate with other atopic conditions like allergic rhinitis, bronchial asthma, and eczema. The initial presentation includes symptoms of esophageal dysfunction, classically solid-food dysphagia. Without treatment, inflammation can progress to fibrosis with the formation of strictures, leading to complications such as food impaction...
April 2024: Mayo Clinic Proceedings
https://read.qxmd.com/read/38599622/over-the-scope-clip-as-first-line-treatment-of-peptic-ulcer-bleeding-a-multicentre-randomized-controlled-trial-top-study
#13
Paola Soriani, Paolo Biancheri, Giuliano Francesco Bonura, Tommaso Gabbani, Enrique Rodriguez de Santiago, Lorenzo Dioscoridi, Gianluca Andrisani, Carmelo Luigiano, Simona Deiana, Joachim Rainer, Mariagrazia Del Buono, Rocco Amendolara, Massimiliano Marino, Cesare Hassan, Alessandro Repici, Mauro Manno
BACKGROUND: First-line over-the-scope-clip (OTSC) treatment has shown higher efficacy than standard endoscopic therapy in acute non-variceal upper gastrointestinal bleeding (UGIB) from different causes. We performed a head-to-head randomized controlled trial (RCT) comparing OTSC vs through-the-scope-clip (TTSC) as first-line mechanical treatment in the specific setting of peptic ulcer (PU) bleeding. METHODS: We conducted an international, multicenter RCT on consecutive patients with suspected UGIB...
April 10, 2024: Endoscopy
https://read.qxmd.com/read/38587292/the-role-of-the-gastroenterologist-in-obesity-management-now-is-the-right-time-for-our-involvement
#14
JOURNAL ARTICLE
Stephanie L Gold, Asher Kornbluth
No abstract text is available yet for this article.
April 8, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38627031/british-society-of-gastroenterology-guidelines-for-the-management-of-hepatocellular-carcinoma-in-adults
#15
JOURNAL ARTICLE
Abid Suddle, Helen Reeves, Richard Hubner, Aileen Marshall, Ian Rowe, Dina Tiniakos, Stefan Hubscher, Mark Callaway, Dinesh Sharma, Teik Choon See, Maria Hawkins, Suzanne Ford-Dunn, Sarah Selemani, Tim Meyer
Deaths from the majority of cancers are falling globally, but the incidence and mortality from hepatocellular carcinoma (HCC) is increasing in the United Kingdom and in other Western countries. HCC is a highly fatal cancer, often diagnosed late, with an incidence to mortality ratio that approaches 1. Despite there being a number of treatment options, including those associated with good medium to long-term survival, 5-year survival from HCC in the UK remains below 20%. Sex, ethnicity and deprivation are important demographics for the incidence of, and/or survival from, HCC...
April 16, 2024: Gut
https://read.qxmd.com/read/38582271/comparison-of-vonoprazan-versus-intravenous-proton-pump-inhibitor-for-prevention-of-high-risk-peptic-ulcers-rebleeding-after-successful-endoscopic-hemostasis-a-multicenter-randomized-noninferiority-trial
#16
JOURNAL ARTICLE
Tanawat Geeratragool, Uayporn Kaosombatwattana, Arpapun Boonchote, Suvikrom Chatthammanat, Nutchanun Preechakawin, Jompol Srichot, Asawin Sudcharoen, Pavapol Sirisunhirun, Panotpol Termsinsuk, Manus Rugivarodom, Julajak Limsrivilai, Monthira Maneerattanaporn, Nonthalee Pausawasdi, Somchai Leelakusolvong
BACKGROUND & AIMS: High-dose proton pump inhibitor (PPI) therapy has been recommended to prevent rebleeding of high-risk peptic ulcer (PU) after hemostasis. Vonoprazan has been proven to be noninferior to PPIs in various acid-related diseases. This study aims to compare the efficacy of vonoprazan versus PPI for preventing high-risk PU rebleeding after hemostasis. METHODS: A multicenter, randomized, noninferiority study was conducted in 6 centers. Pre-endoscopic and endoscopic therapy were performed according to standard protocol...
April 5, 2024: Gastroenterology
https://read.qxmd.com/read/38554104/magnetic-resonance-enterography-and-intestinal-ultrasound-for-the-assessment-and-monitoring-of-crohn-s-disease
#17
JOURNAL ARTICLE
Shankar Kumar, Isabelle De Kock, William Blad, Richard Hare, Richard Pollok, Stuart A Taylor
Magnetic resonance enterography (MRE) and intestinal ultrasound (IUS) have developed rapidly in the last few decades, emerging as the primary non-invasive options for both diagnosing and monitoring Crohn's disease (CD). In this review, we evaluate the pertinent data relating to the use of MRE and IUS in CD. We summarise the key imaging features of CD activity, highlight their increasing role in both the clinical and research settings, and discuss how these modalities fit within the diagnostic pathway. We discuss how they can be used to assess disease activity and treatment responsiveness, including the emergence of activity scores for standardised reporting...
March 30, 2024: Journal of Crohn's & Colitis
https://read.qxmd.com/read/38558880/-helicobacter-pylori-and-gastrointestinal-cancers-recent-advances-and-controversies
#18
REVIEW
Chuandong Zhang, Yuqi Chen, Yan Long, Huimin Zheng, Jiyong Jing, Wensheng Pan
Helicobacter pylori ( H pylori ), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, linking it to other gastrointestinal malignancies, such as esophageal cancer, liver cancer, pancreatic cancer, gallbladder cancer, and colorectal cancer. In light of the expanding research landscape and the increasing interest in exploring H pylori broader role in gastrointestinal tumorigenesis, this comprehensive review aims to elucidate the relationship between H pylori and gastrointestinal tumors...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38595149/central-neuromodulators-in-irritable-bowel-syndrome-why-how-and-when
#19
JOURNAL ARTICLE
Ignacio Hanna-Jairala, Douglas A Drossman
Irritable bowel syndrome are responsive to treatments using central neuromodulators. Central neuromodulators work by enhancing the synaptic transmission of 5-hydroxytryptamine, noradrenalin and dopamine, achieving a slower regulation or desensitization of their postsynaptic receptors. Central neuromodulators act on receptors along the brain-gut axis, so they are useful in treating psychiatric comorbidities, modifying gut motility, improving central downregulation of visceral signals and enhancing neurogenesis in patients with IBS...
April 9, 2024: American Journal of Gastroenterology
https://read.qxmd.com/read/38578541/apasl-clinical-practice-guidelines-on-the-management-of-acute-kidney-injury-in-acute-on-chronic-liver-failure
#20
EDITORIAL
Rakhi Maiwall, Satender Pal Singh, Paolo Angeli, Richard Moreau, Aleksander Krag, Virender Singh, Ashwani K Singal, S S Tan, Puneet Puri, Mamun Mahtab, George Lau, Qin Ning, Manoj Kumar Sharma, P N Rao, Dharmesh Kapoor, Subhash Gupta, Ajay Duseja, Manav Wadhawan, Dinesh Jothimani, Sanjiv Saigal, Sunil Taneja, Akash Shukla, Pankaj Puri, Deepak Govil, Gaurav Pandey, Kaushal Madan, C E Eapen, Jaya Benjamin, Ashok Chowdhury, Shweta Singh, Vaishali Salao, Jin Mo Yang, Saeed Hamid, Shalimar, Sanjiv Jasuja, Anand V Kulkarni, Madund A Niriella, Harsh Vardhan Tevethia, Vinod Arora, R P Mathur, Akash Roy, Ankur Jindal, Neeraj Saraf, Nipun Verma, Arka De, Narendra S Choudhary, Rohit Mehtani, Phool Chand, Omkar Rudra, Shiv Kumar Sarin
Acute-on-chronic liver failure (ACLF) is a syndrome that is characterized by the rapid development of organ failures predisposing these patients to a high risk of short-term early death. The main causes of organ failure in these patients are bacterial infections and systemic inflammation, both of which can be severe. For the majority of these patients, a prompt liver transplant is still the only effective course of treatment. Kidneys are one of the most frequent extrahepatic organs that are affected in patients with ACLF, since acute kidney injury (AKI) is reported in 22...
April 5, 2024: Hepatology International
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