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Cardiac Markers and Conditions and Kidney

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62 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Renske Wiersema, Jacqueline Koeze, Bart Hiemstra, Ville Pettilä, Anders Perner, Frederik Keus, Iwan C C van der Horst
BACKGROUND: Acute kidney injury (AKI) occurs in up to 50% of all critically ill patients and hemodynamic abnormalities are assumed to contribute, but their nature and share is still unclear. We explored the associations between hemodynamic variables, including cardiac index and right ventricular function, and the occurrence of AKI in critically ill patients. METHODS: In this prospective cohort study, we included all patients acutely admitted to an intensive care unit (ICU)...
March 13, 2019: Annals of Intensive Care
Vikas Srinivasan Sridhar, Michael Chen, Howard Gerson, Elizabeth MacNamara, Sharon J Nessim
Background: Cardiac troponins are the preferred biomarker to diagnose myocardial injury. Complicating the interpretation of serial troponins in patients with end-stage renal disease, it has been shown that the hemodialysis procedure results in a small but significant decline in high-sensitivity cardiac troponins (hs-cTnT). This raises the possibility that continuous renal replacement therapy (CRRT) might similarly alter cardiac troponin levels and affect their interpretation when cardiac ischemia is being considered...
2019: Canadian Journal of Kidney Health and Disease
Wei-Jie Bei, Kun Wang, Hua-Long Li, Xiao-Sheng Guo, Wei Guo, Tuerxunjiang Abuduaini, Shi-Qun Chen, Sheikh Mohammed Shariful Islam, Peng-Yuan Chen, Ji-Yan Chen, Yong Liu, Ning Tan
An optimal hydration volume (HV) that prevents contrast-induced acute kidney injury (CI-AKI) in patients with renal insufficiency and heart failure (HF) at a high risk of worsening HF (WHF) has not been determined. We aimed to determine a safe HV that prevents CI-AKI and WHF following coronary angiography (CAG) or percutaneous coronary intervention (PCI) in patients with renal insufficiency and HF. We recruited 1,307 patients with renal insufficiency and HF and investigated the relationships between the peri-procedural HV/weight (HV/W) ratio, and the risks of CI-AKI and WHF following CAG or PCI...
February 22, 2019: International Heart Journal
Akihiro Shirakabe, Noritake Hata, Nobuaki Kobayashi, Hirotake Okazaki, Masato Matsushita, Yusaku Shibata, Saori Uchiyama, Tomofumi Sawatani, Kuniya Asai, Wataru Shimizu
AIMS: The importance of true worsening renal failure (WRF), which is associated with a poor prognosis, had been suggested in patients with acute heart failure (AHF). The aim of the present study was to establish the biomarker strategy for the prediction of true WRF in AHF. METHODS AND RESULTS: Two hundred eighty-one patients with AHF were analysed. Their biomarkers were measured within 30 min of admission. Patients were assigned to the non-WRF (n = 168), pseudo-WRF (n = 56), or true-WRF (n = 57) groups using the criteria of both acute kidney injury on admission and increasing serum creatinine value during the first 7 days...
February 23, 2019: ESC Heart Failure
Markus P Schneider, Johannes B Scheppach, Ulrike Raff, Sebastian Toncar, Christian Ritter, Thorsten Klink, Stefan Störk, Christoph Wanner, Georg Schlieper, Turgay Saritas, Sebastian D Reinartz, Jürgen Floege, Nele Friedrich, Rolf Janka, Michael Uder, Roland E Schmieder, Kai-Uwe Eckardt
Introduction: The high burden of left ventricular (LV) abnormalities in patients with advanced chronic kidney disease (CKD) is well established. However, less is known about the prevalence, patterns, and determinants of LV abnormalities in patients with early CKD. Methods: We examined LV structure in 290 patients with a median estimated glomerular filtration rate (eGFR) of 51 ml/min per 1.73 m2 by magnetic resonance imaging (MRI). We explored associations with clinical and hemodynamic parameters, hydration (bioimpedance), endothelial function, inflammation (including C-reactive protein and tumor necrosis factor-α and its soluble receptors) and mineral bone disease (MBD) markers (including vitamin D, parathyroid hormone, α-klotho and fibroblast growth factor-23)...
February 2019: KI Reports
Yi-Hsin Chen, Yun-Ching Fu, Ming-Ju Wu
N-terminal pro b-type natriuretic peptide (NT-proBNP) was considered a prognostic factor for mortality in hemodialysis patients in previous studies. However, NT-proBNP has not been fully explored in terms of predicting other clinical outcomes in hemodialysis patients. This study aimed to investigate if NT-proBNP could predict emergency department (ED) visits, hospitalization, admission to intensive-care unit (ICU), and cardiovascular incidents in hemodialysis patients. Serum NT-proBNP and other indicators were collected in 232 hemodialysis patients...
February 12, 2019: Journal of Clinical Medicine
Leszek Gromadziński, Beata Januszko-Giergielewicz, Kamila Czarnacka, Piotr Pruszczyk
BACKGROUND: The risk of cardiovascular (CV) complications is much greater in patients with chronic kidney disease (CKD). The aim of this study was to assess predictors of mortality, renal failure progression, and the need for dialysis in patients with CKD. METHODS: The study group consisted of 70 patients with stage 3-5 CKD, followed up on average for 33.4 ± 15.6 months. Laboratory tests and echocardiography were performed on all patients. Composite endpoints were defined as (1) all-cause mortality and (2) mortality or renal replacement therapy (RRT), defined as the initiation of dialysis therapy...
February 6, 2019: Cardiorenal Medicine
Javad Savoj, Brian Becerra, Jin K Kim, Maria Fusaro, Maurizio Gallieni, Dawn Lombardo, Wei Ling Lau
Cardiovascular disease is prevalent in patients with chronic kidney disease (CKD) and responsible for approximately half of all CKD-related deaths. Unfortunately, the presence of CKD can lead to a challenging interpretation of cardiac biomarkers essential in accurate diagnosis and prompt management of heart failure and acute coronary syndrome. There is growing interest in novel cardiac biomarkers that may improve diagnostic accuracy reflecting myocardial injury, inflammation, and remodeling. Interpretation of these biomarkers in CKD can be complicated, since elevated levels may not reflect myocardial injury or wall tension but rather decreased urinary clearance with retention of solutes and/or overall CKD-associated chronic inflammation...
February 6, 2019: Nephron
Tushar Kotecha, Ana Martinez-Naharro, Suree Yoowannakul, Tabitha Lambe, Tamer Rezk, Daniel S Knight, Philip N Hawkins, James C Moon, Vivek Muthurangu, Peter Kellman, Roby D Rakhit, Julian D Gillmore, Paramjit Jeetley, Andrew Davenport, Marianna Fontana
In patients with chronic kidney disease (CKD), reverse left ventricular (LV) remodelling, including reduction in LV mass, can be observed following long-term haemodialysis (HD) and has been attributed to regression of LV hypertrophy. However, LV mass can vary in response to changes in myocyte volume, edema, or fibrosis. The aims of this study were to investigate the acute changes in structural (myocardial mass and biventricular volumes) and tissue characterization parameters (native T1 and T2) following HD using cardiovascular magnetic resonance (CMR)...
February 4, 2019: Scientific Reports
Xiaoliang Wang, Joseph I Shapiro
The term uraemic cardiomyopathy refers to the cardiac abnormalities that are seen in patients with chronic kidney disease (CKD). Historically, this term was used to describe a severe cardiomyopathy that was associated with end-stage renal disease and characterized by severe functional abnormalities that could be reversed following renal transplantation. In a modern context, uraemic cardiomyopathy describes the clinical phenotype of cardiac disease that accompanies CKD and is perhaps best characterized as diastolic dysfunction seen in conjunction with left ventricular hypertrophy and fibrosis...
January 21, 2019: Nature Reviews. Nephrology
Mohammad Saad Forghani, Mohammad Sedigh Jadidoleslami, Seyyed Nima Naleini, Mohsen Rajabnia
BACKGROUND: Hemodialysis patients are at high risk for cardiovascular diseases. The prognostic value of cardiac troponins, albumin and CRP in hemodialysis patients and their association with cardiac diseases has been proven. The aim of this study was to investigate the relationship between these factors and heart failure and left ventricular hypertrophy in hemodialysis patients in Sanandaj city. METHODS: A total of 90 hemodialysis patients referred to hemodialysis ward of Tohid Medical Center of Sanandaj were enrolled in the study...
January 2019: Diabetes & Metabolic Syndrome
Joanna Szczykowska, Tomasz Hryszko, Beata Naumnik
Troponin measurement is one of crucial assessments facilitating diagnosis of acute coronary syndrome. Patients with chronic kidney disease are decimated by cardiovascular disease. Unfortunately, elevated concentration of serum troponin is commonly faced in clinical practice creating a challenge to rule out acute cardiac ischaemia in this vulnerable population. This review presents current knowlegde on analytical differences in troponin T and I measurements, their prognostic significance and their application in diagnosing acute coronary syndrome in chronic kidney disease patients...
January 11, 2019: Advances in Medical Sciences
Ashok Kumar Pannu, Mridul Dutta, Huidrom Manimohon Singh
No abstract text is available yet for this article.
December 28, 2018: QJM: Monthly Journal of the Association of Physicians
Huiliang Qiu, Chunlan Ji, Wei Liu, Yuchi Wu, Zhaoyu Lu, Qizhan Lin, Zheng Xue, Xusheng Liu, Huanlin Wu, Wei Jiang, Chuan Zou
Chronic kidney disease (CKD) causes atrial structural remodeling and subsequently increases the incidence of atrial fibrillation (AF). Atrial connexins and inflammatory responses may be involved in this remodeling process. In this study, nephrectomy was used to produce the CKD rat model. Three months post-nephrectomy, cardiac structure, function and AF vulnerability were quantified using echocardiography and electrophysiology methods. The left atrial tissue was tested for quantification of fibrosis and inflammation, and for the distribution and expression of connexin (Cx) 40 and Cx43...
2018: Frontiers in Physiology
Andrzej Jaroszyński, Anna Jaroszyńska, Tomasz Zaborowski, Anna Drelich-Zbroja, Tomasz Zapolski, Wojciech Dąbrowski
BACKGROUND: Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as well as to evaluate factors associated with HSP27 level in a group of patients treated with HD. METHODS: Enrolled to the study were 202 HD patients. Clinical data, biochemical, echocardiographic, and carotid atherosclerosis parameters were evaluated...
December 17, 2018: BMC Nephrology
Ruth F Dubin, Mary Whooley, Alexander Pico, Peter Ganz, Nelson B Schiller, Craig Meyer
BACKGROUND: Patients with chronic kidney disease (CKD) are at increased risk for heart failure (HF). We aimed to investigate differences in proteins associated with HF hospitalizations among patients with and without CKD in the Heart and Soul Study. METHODS AND RESULTS: We measured 1068 unique plasma proteins from baseline samples of 974 participants in The Heart and Soul Study who were followed for HF hospitalization over a median of 7 years. We sequentially applied forest regression and Cox survival analyses to select prognostic proteins...
2018: PloS One
Jacques Ducros, Laurent Larifla, Henri Merault, Lydia Foucan
BACKGROUND: We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW). METHODS: A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2 , serum creatinine ≤ 818  µ mol/L, and normalized protein catabolic rate (nPCR) ≤ 0...
2017: International Journal of Nephrology
Maura Ravera, Gian Marco Rosa, Paolo Fontanive, Elisabetta Bussalino, Ulrico Dorighi, Daniela Picciotto, Luca Di Lullo, Frank Lloyd Dini, Ernesto Paoletti
BACKGROUND: Although heart failure is the most prevalent cardiovascular disease associated with adverse outcome in chronic kidney disease (CKD) and after kidney transplantation, left ventricular (LV) systolic function is often preserved in renal patients. The aim of this study was to evaluate global longitudinal strain (GLS), which is reportedly a more accurate tool for detecting subclinical LV systolic dysfunction, in patients with various degrees of renal function impairment, including kidney transplant recipients (KTRs)...
2019: Cardiorenal Medicine
Eglė Tamulėnaitė, Rūta Žvirblytė, Rūta Ereminienė, Edita Žiginskienė, Eglė Ereminienė
Background and objectives : Chronic kidney disease (CKD) increases the risk of cardiovascular diseases even in its early stages and is associated with structural and functional cardiac abnormalities. The aim of this study was to use speckle-tracking echocardiography (STE) to evaluate left and right ventricle mechanics and function, markers of subclinical dysfunction in patients with end-stage renal disease (ESRD) undergoing haemodialysis. Methods : Patients with ESRD undergoing regular haemodialysis and with preserved left ventricle (LV) ejection fraction (EF) ( n = 38) were enrolled in this retrospective study...
November 13, 2018: Medicina
Elena Dozio, Federico Ambrogi, Massimo de Cal, Elena Vianello, Claudio Ronco, Massimiliano M Corsi Romanelli
End-stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate due to cardiovascular diseases (CVD). In these patients, inflammation, oxidative stress, and uremia increase the production of glycation products (AGEs) which in turn accelerate CVD onset and progression. Recently, attention has been given to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis, and heart failure in CKD-G5D. However, its association with patient outcomes is still under debate...
2018: Mediators of Inflammation
2018-11-11 11:09:50
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