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REVIEW
Thanat Chaikijurajai, Sevag Demirjian, W H Wilson Tang
Background Natriuretic peptides have been recommended as biomarkers for the diagnosis and prognosis of patients with heart failure and are often elevated in the setting of acute kidney injury. We sought to demonstrate the associations between increased baseline NT-proBNP (N-terminal pro-B-type natriuretic peptide) and adverse renal outcomes in patients with moderate-to-severe acute kidney injury. Methods and Results We reviewed electronic medical records of consecutive patients with acute kidney injury stage 2 and 3 admitted to the Cleveland Clinic between September 2011 and December 2021...
November 7, 2023: Journal of the American Heart Association
#22
RANDOMIZED CONTROLLED TRIAL
Katherine A Curtis, Sushrut S Waikar, Finnian R Mc Causland
INTRODUCTION: Elevated N-terminal pro B-type natriuretic peptide (NT-proBNP) is a potent predictor of adverse outcomes in hemodialysis initiation. These patients often experience intradialytic hypotension, which may partially reflect cardiac dysfunction, but the association of NT-proBNP with intradialytic hypotension is not clear. METHODS: We performed a post hoc analysis of a randomized trial that tested mannitol versus placebo in 52 patients initiating hemodialysis (NCT01520207)...
January 2024: Hemodialysis International
#23
JOURNAL ARTICLE
Roy O Mathew, Janani Rangaswami, Dmitry Abramov, Gauranga Mahalwar, Shaitalya Vellanki, Farah Abuazzam, Gary E Fraser, Fayth Miles Butler, Kevin Bryan Lo, Charles A Herzog, Gautam R Shroff, Mandeep S Sidhu, Sripal Bangalore
AIMS: This analysis evaluates whether proportional serial cardiac troponin (cTn) change predicts benefit from an early versus delayed invasive, or conservative treatment strategies across kidney function in non-ST-elevation acute coronary syndrome (NSTE-ACS). METHODS: Patients diagnosed with NSTE-ACS in the Veterans Health Administration between 1999 and 2022 were categorized into terciles (<20%, 20 to ≤80%, >80%) of proportional change in serial cTn...
October 23, 2023: Catheterization and Cardiovascular Interventions
#24
JOURNAL ARTICLE
Jwan A Naser, Sushil Allen Luis, Sorin V Pislaru, Hector I Michelena, Austin M Kennedy, Mackram F Eleid, Juan A Crestanello, Fouad T Chebib, Patricia A Pellikka, Vuyisile T Nkomo
Transcatheter aortic valve replacement (TAVR) is now widely approved for the treatment of aortic stenosis regardless of patients' surgical risk. However, outcomes of TAVR and their determinants in patients with chronic kidney disease (CKD) beyond 1 year of follow-up are unknown. We aimed to assess medium-term outcomes of TAVR in CKD, develop a risk score to estimate the 2-year mortality in CKD patients, and evaluate changes in kidney function at discharge after TAVR. Adults who underwent TAVR were retrospectively identified...
October 18, 2023: American Journal of Cardiology
#25
JOURNAL ARTICLE
Lucile Mercadal, Jean-Jacques Boffa, Jean-Philippe Collet
Especially exposed to frequent cardiovascular events and its related mortality, some cardiovascular therapies of the hemodialyzed population as well as coronary investigations remain controversial. We have collected data and discussed recent trials and guidelines dedicated to this patient subset.
October 17, 2023: Néphrologie & Thérapeutique
#26
Sofia Spano, Akinori Maeda, Joey Lam, Anis Chaba, Emily See, Peter Mount, Mina Nichols-Boyd, Rinaldo Bellomo
INTRODUCTION: Renal Replacement Therapy (RRT) is associated with hypotension. However, its impact on cardiac output (CO) is less understood. We aimed to describe current knowledge of CO monitoring and changes during RRT. METHODS: We searched Medline, Embase and Cochrane from 01/01/2000 to 31/01/2023 using Covidence for studies of intermittent hemodialysis (IHD) and continuous RRT (CRRT) with at least three CO measurements during treatment. Two independent reviewers screened citations and a third resolved disagreements...
October 14, 2023: Blood Purification
#27
JOURNAL ARTICLE
Sijia Yu, Qiang Li, Yibo He, CongZhuo Jia, Guoxiao Liang, Hongyu Lu, Wanying Wu, Jin Liu, Yong Liu, Jiyan Chen
AIM: Cardiac biomarkers' predictive value of contrast-associated acute kidney injury (CA-AKI) remains unclear. We analysed whether creatine kinase isoenzyme-MB (CKMB), cardiac troponin I (cTnI) and preoperative N-terminal pro-brain natriuretic peptide (NT-proBNP) are tied to CA-AKI patients undergoing cardiac catheterization. METHODS: In the multi-center study, we included 3553 people underwent cardiac catheterization for analysis. CA-AKI was defined as the absolute increase of over 0...
August 24, 2023: Nephrology
#28
REVIEW
Michael Mejer Hunderup, Jan Dominik Kampmann, Frans Brandt Kristensen, Marius Hafsund
INTRODUCTION: Patients with end-stage renal disease (ESRD) have an increased risk of cardiovascular disease, but interpreting cardiac troponin is difficult in this population. The effect of renal replacement therapy (RRT) is important to consider when interpreting serial cardiac troponin T (cTnT) results for patients with ESRD suspected of acute coronary syndrome (ACS). The aim of this systematic review is to answer how low-flux hemodialysis (LF-HD), high-flux hemodialysis (HF-HD), and hemodiafiltration (HDF) affect the blood concentration of high-sensitive cardiac troponin T (hs-cTnT)...
2024: Seminars in Dialysis
#29
REVIEW
Adrian daSilva-deAbreu, Christian Faaborg-Andersen, Abdulaziz Joury, Austin Tutor, Sapna Desai, Clement Eiswirth, Selim R Krim, James Wever-Pinzon, Carl J Lavie, Hector O Ventura
INTRODUCTION: Patients with left ventricular assist devices (LVADs) who require intermittent hemodialysis (iHD) are considered to have a poor prognosis despite a paucity of supportive evidence, mostly from small single-center cohorts and extrapolations from studies of patients who received continuous renal replacement therapy but no iHD. METHODS/RESULTS: We conducted a systematic review and individual-participant-data meta-analysis of the literature including our single-center cohort to examine the outcomes of patients initiated on iHD following LVAD implantation...
September 19, 2023: Current Problems in Cardiology
#30
JOURNAL ARTICLE
Daniel Murphy, Sami Firoozi, Charles A Herzog, Debasish Banerjee
Cardiac troponins (cTn) are routinely measured for the diagnosis and prognosis of myocardial infarction (MI). The relation between troponin levels, estimated glomerular filtration rate (eGFR), postinfarction heart failure (HF), and mortality is unclear in patients with kidney impairment. This is a retrospective, cross-sectional study of patients presenting to the Emergency Department at a single tertiary center. Participants presenting with confirmed type I MI from January 1, 2019, to December 31, 2021, were analyzed from the Myocardial Ischemia National Audit Project database...
October 1, 2023: American Journal of Cardiology
#31
EDITORIAL
Daniel W Coyne
No abstract text is available yet for this article.
September 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
#32
JOURNAL ARTICLE
Guillaume Jean, Walid Arkouche, Jean-Michel Poux
No abstract text is available yet for this article.
August 3, 2023: Néphrologie & Thérapeutique
#33
JOURNAL ARTICLE
Guillaume Jean, Walid Arkouche, Jean-Michel Poux
No abstract text is available yet for this article.
July 13, 2023: Néphrologie & Thérapeutique
#34
RANDOMIZED CONTROLLED TRIAL
Iain C Macdougall, Piotr Ponikowski, Austin G Stack, David C Wheeler, Stefan D Anker, Javed Butler, Gerasimos Filippatos, Udo-Michael Göhring, Bridget-Anne Kirwan, Vasuki Kumpeson, Marco Metra, Giuseppe Rosano, Frank Ruschitzka, Peter van der Meer, Sandra Wächter, Ewa A Jankowska
BACKGROUND: Reduced kidney function is common among patients with heart failure. In patients with heart failure and/or kidney disease, iron deficiency is an independent predictor of adverse outcomes. In the AFFIRM-AHF trial, patients with acute heart failure with iron deficiency treated with intravenous ferric carboxymaltose demonstrated reduced risk of heart failure hospitalization, with improved quality of life. We aimed to further characterize the impact of ferric carboxymaltose among patients with coexisting kidney impairment...
September 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
#35
JOURNAL ARTICLE
H K Chopra, G S Wander, Tiny Nair, C K Ponde, Navin C Nanda, Jagat Narula, Saumitra Ray, K Venugopal, S S Iyengar, R R Kasliwal, Praveen Chandra, Sunil Prakash, Sandeep Bansal, D S Rana, Prafulla Kerkar, Arup Dasbiswas, Jps Sawhney, S Shanmungasundram, Viveka Kumar, I B Vijayalakshmi, A K Pancholia, Vinod Sharma, Aditya Kapoor, Onkar C Swami, H S Isser, Vishal Rastogi, Y K Arora, Ashok K Omar, Sunil Sathe, Rajeeve Rajput, D Prabhakar, G J Paul, Priya Jagia, Poonam Malhotra, G Suryaprakash, Vinod Mittal, Manish Jagia, A Jabir, S S Mishra, S N Routray, Ajay K Sinha, Mohan Bhargava, Kiran Mahmood, Mona Bhatia, Pramila Kalra, V K Katyal, Rohit Tandon, Rahul Grover, Abhinav Chhabra, N R Shastry
Iron deficiency (ID) with or without anemia is frequently observed in patients with heart failure (HF). Uncorrected ID is associated with higher hospitalization and mortality in patients with acute HF (AHF) and chronic HF (CHF). Hence, in addition to chronic renal insufficiency, anemia, and diabetes, ID appears as a novel comorbidity and a treatment target of CHF. Intravenous (IV) ferric carboxymaltose (FCM) reduces the hospitalization risk due to HF worsening and improves functional capacity and quality of life (QOL) in HF patients...
March 2023: Journal of the Association of Physicians of India
#36
JOURNAL ARTICLE
Alexandre Candellier, Yohann Bohbot, Agnes Pasquet, Momar Diouf, Emmanuelle Vermes, Eric Goffin, Mesut Gun, Fanny Peugnet, Lucie Hénaut, Dan Rusinaru, Romuald Mentaverri, Saïd Kamel, Gabriel Choukroun, Jean-Louis Vanoverschelde, Christophe Tribouilloy
BACKGROUND: Rapid progression of aortic stenosis (AS) has been observed in patients undergoing dialysis, but existing cross-sectional evidence is contradictory in non-dialysis-dependent chronic kidney disease (CKD). The present study sought to evaluate whether CKD is associated with the progression of AS over time in a large cohort of patients with AS. METHODS: We retrospectively studied all consecutive patients diagnosed with AS (peak aortic jet velocity [Vmax] ≥ 2...
May 29, 2023: Nephrology, Dialysis, Transplantation
#37
JOURNAL ARTICLE
Arun Karat Anandan, Gomathy Sankaranarayanan, Usha Samuel, Sivaprasad Kunjukrishnapilla, Venugopal Panicker, Josey Verghese, Gagan Velayudhan
It is well known that chronic kidney disease (CKD) is associated with significant morbidity and mortality, predominantly due to cardiovascular complications. Recent literature report pulmonary hypertension (PH) as a common accompaniment of CKD and in majority of these cases, secondary causes of PH are not evident. In this study, we looked at the prevalence and possible risk factors of PH in stage 5 CKD patients with a special focus on unexplained PH. In this cross-sectional study, 100 stage 5 CKD patients [50 each on maintenance hemodialysis (HD) and conservative management] were included...
February 2022: Saudi Journal of Kidney Diseases and Transplantation
#38
COMPARATIVE STUDY
Carl P Walther, Sankar D Navaneethan
Japanese and US populations have similar chronic kidney disease prevalence but differing clinical outcomes. A secondary analysis compared cardiovascular outcomes in a Japanese- and a US-based chronic kidney disease cohort and found that the US cohort had markedly worse cardiovascular outcomes. Mediation analysis demonstrated that differences in left ventricular structure and function could explain most of the cardiovascular outcome difference. We examine and contextualize this finding and describe implications for precision nephrology and for population health...
May 2023: Kidney International
#39
JOURNAL ARTICLE
Leonardo Pozo Garcia, Carl P Walther
PURPOSE OF REVIEW: Mechanical circulatory support (MCS) is a group of evolving therapies used for indications ranging from temporary support during a cardiac procedure to permanent treatment of advanced heart failure. MCS is primarily used to support left ventricle function, in which case the devices are termed left ventricular assist devices (LVADs). Kidney dysfunction is common in patients requiring these devices, yet the impact of MCS itself on kidney health in many settings remains uncertain...
May 3, 2023: Current Opinion in Nephrology and Hypertension
#40
JOURNAL ARTICLE
Van Thanh Nguyen, Bui Van Pham, Thao Thi Thu Le, Chien Duc Vo, Dung Quang Nguyen, Nguyen Ngoc Tran
INTRODUCTION: This study aimed to evaluate the effects of dialysis on change of QT interval in pre-dialysis, 1 h after dialysis initiation, and post-dialysis period in patients on maintenance dialysis (MHD). METHODS: An observational prospective study was conducted, including 61 patients, on thrice-weekly MHD ≥3 months, and without acute diseases, at the Nephrology-Dialysis Department of a tertiary hospital in Vietnam. The exclusive criteria were atrial fibrillation, atrial flutter, branch block, prolonged QT recorded in medical history, and taking antiarrhythmic drugs lengthening QT interval before entering the study...
March 30, 2023: Blood Purification
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