Dharani Kumari Narendra, Dean R Hess, Curtis N Sessler, Habtamu M Belete, Kalpalatha K Guntupalli, Felix Khusid, Charles Mark Carpati, Mark Elton Astiz, Suhail Raoof
Mortality related to severe-moderate and severe ARDS remains high. We searched the literature to update this topic. We defined severe hypoxemic respiratory failure as Pao2 /Fio2  < 150 mm Hg (ie, severe-moderate and severe ARDS). For these patients, we support setting the ventilator to a tidal volume of 4 to 8 mL/kg predicted body weight (PBW), with plateau pressure (Pplat) ≤ 30 cm H2 O, and initial positive end-expiratory pressure (PEEP) of 10 to 12 cm H2 O...
October 2017: Chest
Laurent Papazian, Carolyn S Calfee, Davide Chiumello, Charles-Edouard Luyt, Nuala J Meyer, Hiroshi Sekiguchi, Michael A Matthay, Gianfranco Umberto Meduri
Acute respiratory distress syndrome (ARDS) is defined by the association of bilateral infiltrates and hypoxaemia following an initial insult. Although a new definition has been recently proposed (Berlin definition), there are various forms of ARDS with potential differences regarding their management (ventilator settings, prone positioning use, corticosteroids). ARDS can be caused by various aetiologies, and the adequate treatment of the responsible cause is crucial to improve the outcome. It is of paramount importance to characterize the mechanisms causing lung injury to optimize both the aetiological treatment and the symptomatic treatment...
May 2016: Intensive Care Medicine
Alejandro A Rabinstein
PURPOSE OF REVIEW: Neuromuscular respiratory failure can occur from a variety of diseases, both acute and chronic with acute exacerbation. There is often a misunderstanding about how the nature of the neuromuscular disease should affect the decision on how to ventilate the patient. This review provides an update on the value and relative contraindications for the use of noninvasive ventilation in patients with various causes of primary neuromuscular respiratory failure. RECENT FINDINGS: Myasthenic crisis represents the paradigmatic example of the neuromuscular condition that can be best treated with noninvasive ventilation...
April 2016: Current Opinion in Critical Care
Jean-Louis Vincent, Daniel De Backer
New England Journal of Medicine, Volume 369, Issue 18, Page 1726-1734, October 2013.
October 31, 2013: New England Journal of Medicine
Michael C Reade, Simon Finfer
No abstract text is available yet for this article.
January 30, 2014: New England Journal of Medicine
E A Deitch
Multiple organ failure (MOF) has reached epidemic proportions in most intensive care units and is fast becoming the most common cause of death in the surgical intensive care unit. Furthermore, in spite of the development of successive generations of new and more powerful antibiotics and increasing sophisticated techniques of organ support, our ability to salvage patients once MOF has become established has not appreciably improved over the last two decades. Clearly, new therapeutic strategies aimed at preventing or limiting the development of the physiologic abnormalities that induce organ failure are needed to improve survival in these critically ill patients...
August 1992: Annals of Surgery
Charalampos Pierrakos, Menelaos Karanikolas, Sabino Scolletta, Vasilios Karamouzos, Dimitrios Velissaris
UNLABELLED: Acute Respiratory Distress Syndrome (ARDS) is a common entity in critical care. ARDS is associated with many diagnoses, including trauma and sepsis, can lead to multiple organ failure and has high mortality. The present article is a narrative review of the literature on ARDS, including ARDS pathophysiology and therapeutic options currently being evaluated or in use in clinical practice. The literature review covers relevant publications until January 2011. Recent developments in the therapeutic approach to ARDS include refinements of mechanical ventilatory support with emphasis on protective lung ventilation using low tidal volumes, increased PEEP with use of recruitment maneuvers to promote reopening of collapsed lung alveoli, prone position as rescue therapy for severe hypoxemia, and high frequency ventilation...
February 2012: Journal of Clinical Medicine Research
William Bernal, Julia Wendon
No abstract text is available yet for this article.
December 26, 2013: New England Journal of Medicine
Jan J De Waele
PURPOSE OF REVIEW: To review the changing insights in the pathophysiology and management of acute pancreatitis. RECENT FINDINGS: The outdated 1992 Atlanta classification has been replaced by two new classifications, both of which acknowledge the role of organ dysfunction in determining the outcome of acute pancreatitis, and both of which have introduced a new category of 'moderate' pancreatitis. The new classifications will allow fewer patients to be classified as severe, which better reflects the risk of dying of the disease...
April 2014: Current Opinion in Critical Care
Beverley J Hunt
No abstract text is available yet for this article.
February 27, 2014: New England Journal of Medicine
Chris Willars
PURPOSE OF REVIEW: Acute liver failure (ALF) is associated with significant mortality. Although specific therapies may be available, the evidence base for these and for many aspects of supportive therapy has been slow to emerge. Liver transplantation continues to be a cornerstone of treatment, and the management of ALF, therefore, remains the domain of the specialist ICU. The purpose of this review is to identify and critically appraise the recent evidence and to inspire those who strive to provide excellent care for a difficult patient cohort...
April 2014: Current Opinion in Critical Care
Donald M Yealy, John A Kellum, David T Huang, Amber E Barnato, Lisa A Weissfeld, Francis Pike, Thomas Terndrup, Henry E Wang, Peter C Hou, Frank LoVecchio, Michael R Filbin, Nathan I Shapiro, Derek C Angus
BACKGROUND: In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary...
May 1, 2014: New England Journal of Medicine
John P Kress, Jesse B Hall
New England Journal of Medicine, Volume 370, Issue 17, Page 1626-1635, April 2014.
April 24, 2014: New England Journal of Medicine
Pierre Asfar, Jean-Louis Teboul, Peter Radermacher
New England Journal of Medicine, Volume 371, Issue 3, Page 282-284, July 2014.
July 17, 2014: New England Journal of Medicine
John C Marshall
No abstract text is available yet for this article.
August 19, 2014: Annals of Internal Medicine
Bram Rochwerg, Waleed Alhazzani, Anees Sindi, Diane Heels-Ansdell, Lehana Thabane, Alison Fox-Robichaud, Lawrence Mbuagbaw, Wojciech Szczeklik, Fayez Alshamsi, Sultan Altayyar, Wang-Chun Ip, Guowei Li, Michael Wang, Anna Wludarczyk, Qi Zhou, Gordon H Guyatt, Deborah J Cook, Roman Jaeschke, Djillali Annane
BACKGROUND: Fluid resuscitation is the cornerstone of sepsis treatment. However, whether balanced or unbalanced crystalloids or natural or synthetic colloids confer a survival advantage is unclear. PURPOSE: To examine the effect of different resuscitative fluids on mortality in patients with sepsis. DATA SOURCES: MEDLINE, EMBASE, ACP Journal Club, CINAHL, HealthSTAR, the Allied and Complementary Medicine Database, and the Cochrane Central Register of Controlled Trials through March 2014...
September 2, 2014: Annals of Internal Medicine
R Phillip Dellinger
No abstract text is available yet for this article.
September 2, 2014: Annals of Internal Medicine
Ronald G Pearl
No abstract text is available yet for this article.
June 17, 2014: Annals of Internal Medicine
Kevin M King, Bruce D Adams
No abstract text is available yet for this article.
June 17, 2014: Annals of Internal Medicine
Brian H Rowe
No abstract text is available yet for this article.
May 20, 2014: Annals of Internal Medicine
2014-06-13 23:08:47
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.